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Full-Text Articles in Medicine and Health Sciences

Morning Meeting And Closing Circles: A Sense Of Community, Positive Learning Environment, And Increased Social Interactions In An Elementary Classroom, Samantha Ryan May 2022

Morning Meeting And Closing Circles: A Sense Of Community, Positive Learning Environment, And Increased Social Interactions In An Elementary Classroom, Samantha Ryan

Master's Theses

This action research study was implemented over a three-week period in a first-grade classroom, collecting qualitative and quantitative data. The purpose of the study was to determine the effects of Morning Meetings and Closing Circles on a sense of community in an elementary classroom. Preliminary findings show an increase in student social interactions, positive learning environment, and a climate of belonging. This presentation will also provide information on Morning Meetings and Closing Circles as an intervention to combat social and emotional competencies lost during the COVID-19 pandemic.


Trusting Your Bearings: Outdoor Navigation And The Link Between Perceived Competence, Actual Skill, And Flow State In The Adirondack Region Of New York, Daria Stacy May 2022

Trusting Your Bearings: Outdoor Navigation And The Link Between Perceived Competence, Actual Skill, And Flow State In The Adirondack Region Of New York, Daria Stacy

Master's Theses

The purpose of this study was to examine the relationship between perceived competence and flow theory in the activity of outdoor navigation. This relationship was examined at beginner, intermediate, advanced, and expert skill levels of navigation, targeting a population in the Adirondack Region due to its challenging, thickly forested terrain. The study used a multi-method approach encompassing both quantitative and qualitative data. Surveys were administered to examine beginner, intermediate, and advanced navigators following a formal navigation course at SUNY Cortland’s Outdoor Education Practicum at Raquette Lake or an Advanced Map and Compass Bushwhack Course or Map and Compass Fundamentals Course …


F. Scott Fitzgerald’S Homme Épuisé: Usurping The “Madwoman” In Tender Is The Night (1934) [2022], Emma Hill May 2022

F. Scott Fitzgerald’S Homme Épuisé: Usurping The “Madwoman” In Tender Is The Night (1934) [2022], Emma Hill

Master's Theses

Nineteenth-century women writers commonly use themes of entrapment and madness in what are now classified as gothic novels. In texts such as Jane Eyre, Frankenstein, and The Yellow Wallpaper, confinement and madness are synchronous in developing the figure of “the madwoman.” These texts were written during a time when it was uncommon for female writers to seek publication, and many used pseudonyms to get their works published or to be taken seriously by critics. The “madwoman” emerged as a powerful trope to articulate what writing under a patriarchal system feels like. That is to say, confinement scenarios resulting from female …


The Index Of Phonetic Complexity: At-A-Glance Scoring System, Terminology, Instructions, & Data Forms, Kathy J. Jakielski May 2022

The Index Of Phonetic Complexity: At-A-Glance Scoring System, Terminology, Instructions, & Data Forms, Kathy J. Jakielski

Building Speech and Quantifying Complexity

This document is the Index of Phonetic Complexity, the at-a-glance scoring system, terminology, instructions, & data forms to accompany Building Speech & Quantifying Complexity. To see the entire series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 1: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 1: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 1: Picture Stimuli is part 1 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 2: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 2: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 2: Picture Stimuli is part 2 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 6: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 6: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 6: Picture Stimuli is part 6 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech And Quantifying Complexity: The Manual, Kathy J. Jakielski May 2022

Building Speech And Quantifying Complexity: The Manual, Kathy J. Jakielski

Building Speech and Quantifying Complexity

This document is the manual to accompany Building Speech & Quantifying Complexity. The full series can be viewed here: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, at one point in time or over time.

The Building Speech …


Building Speech Pattern 4: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 4: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 4: Picture Stimuli is part 4 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 5: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 5: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 5: Picture Stimuli is part 5 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 7: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 7: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 7: Picture Stimuli is part 7 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 3: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 3: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 3: Picture Stimuli is part 3 of 8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, …


Building Speech Pattern 8: Picture Stimuli, Kathy J. Jakielski May 2022

Building Speech Pattern 8: Picture Stimuli, Kathy J. Jakielski

Building Speech and Quantifying Complexity

Building Speech Pattern 8: Picture Stimuli is part 8/8 in the picture stimuli to accompany the Building Speech & Quantifying Complexity documents. To see the full series, visit: https://digitalcommons.augustana.edu/cgi/siteview.cgi/csdbuildingspeech

Building Speech & Quantifying Complexity is a dual approach to treating and evaluating articulatory complexity in child speech. It has two components: Building Speech and Quantifying Complexity. These two components can be used independently or together. When used together, the speech-language pathologist has a method for selecting goals and targets of varying levels of articulatory difficulty, plus a means for measuring changes in a child’s words, targeted and produced, at one …


Eating Disorder Prevention Measures For High Risk Populations In The College Campus Setting, Anna L. Potts May 2022

Eating Disorder Prevention Measures For High Risk Populations In The College Campus Setting, Anna L. Potts

Antonian Scholars Honors Program

Eating disorders (EDs) are complicated and dangerous illnesses that affect mental and physical health. Symptoms may include, but are not limited to, food restriction, vomiting or using laxatives, and/or excessive exercise to prevent weight gain. College students, particularly females, are at an increased risk for ED onset due to external factors such as a change in environment, eating habits, diet culture and high risk of food insecurity in the campus setting. Since St. Catherine University (SCU) has a College for Women, the author wondered why she hadn’t seen more information or initiatives to support ED prevention and recovery within the …


Community Characteristics And Financial And Operational Performance Of Rural Health Clinics In The United States: A Chartbook, John Gale Ms, Zachariah Croll Mph, Jamar Croom Ms, Louisa Munk Mph, Yvonne Jonk Phd May 2022

Community Characteristics And Financial And Operational Performance Of Rural Health Clinics In The United States: A Chartbook, John Gale Ms, Zachariah Croll Mph, Jamar Croom Ms, Louisa Munk Mph, Yvonne Jonk Phd

Rural Health Clinics

This chartbook provides an overview of Rural Health Clinic (RHC) characteristics and issues using data from CMS’s Provider of Services file, Medicare Cost Reports, and the Robert Wood Johnson Foundation’s’ County Health Ranking and will be useful to policymakers and others interested in the performance of RHCs nationally. It can also be useful to RHC administrators to benchmark staffing patterns, productivity, and efficiency. Finally, it provides a discussion of the challenges related to collection and reporting of RHC quality data.

For more information, please contact John Gale, john.gale@maine.edu


Airborne And Dermal Collection Methods Of Gunshot Residue For Toxicity Studies, Samuel Cole Smith, Oscar Beau Black, Courtney Roper May 2022

Airborne And Dermal Collection Methods Of Gunshot Residue For Toxicity Studies, Samuel Cole Smith, Oscar Beau Black, Courtney Roper

Faculty and Student Publications

Gunshot residue (GSR) has potential negative health effects on humans as a result of inhalation and dermal exposure to the chemical and physical characteristics of GSR such as Pb, Sb, Ba, nitrocellulose, nitroglycerine, and particulate size fraction. Filter (size selective) and double-sided tape (non-size selective) samples collected airborne GSR during single and triple firing of a 0.22 caliber revolver. Dermal exposures were considered using hand swabs and de-leading wipes, designed to remove the heavy metals. The samples underwent analysis to investigate physical (morphology, size distribution, zeta potential), chemical (black carbon and element concentrations), and potential to induce oxidative stress (oxidative …


Isolation Of Echimidine And Its C-7 Isomers From Echium Plantagineum L. And Their Hepatotoxic Effect On Rat Hepatocytes, Michał Gleńsk, Marta K. Dudek, Peter Kinkade, Evelyn C.S. Santos May 2022

Isolation Of Echimidine And Its C-7 Isomers From Echium Plantagineum L. And Their Hepatotoxic Effect On Rat Hepatocytes, Michał Gleńsk, Marta K. Dudek, Peter Kinkade, Evelyn C.S. Santos

Faculty and Student Publications

Echimidine is the main pyrrolizidine alkaloid of Echium plantagineum L., a plant domesti-cated in many countries. Because of echimidine’s toxicity, this alkaloid has become a target of the European Food Safety Authority regulations, especially in regard to honey contamination. In this study, we determined by NMR spectroscopy that the main HPLC peak purified from zinc reduced plant extract with an MS [M + H]+ signal at m/z 398 corresponding to echimidine (1), and in fact also represents an isomeric echihumiline (2). A third isomer present in the smallest amount and barely re-solved by HPLC from co-eluting (1) and (2) was …


Development Of Α-Tocopherol Succinate-Based Nanostructured Lipid Carriers For Delivery Of Paclitaxel, Sushrut Marathe, Gauri Shadambikar, Tabish Mehraj, Suresh P. Sulochana May 2022

Development Of Α-Tocopherol Succinate-Based Nanostructured Lipid Carriers For Delivery Of Paclitaxel, Sushrut Marathe, Gauri Shadambikar, Tabish Mehraj, Suresh P. Sulochana

Faculty and Student Publications

The management of retinoblastoma (RB) involves the use of invasive treatment regimens. Paclitaxel (PTX), an effective antineoplastic compound used in the treatment of a wide range of malignant tumors, poses treatment challenges due to systemic toxicity, rapid elimination, and development of resistance. The goal of this work was to develop PTX-loaded, α-tocopherol succinate (αTS)-based, nanostructured lipid carrier (NLCs; αTS-PTX-NLC) and PEGylated αTS-PTX-NLC (αTS-PTX-PEG-NLC) to improve ocular bioavailability. The hot homogenization method was used to prepare the NLCs, and repeated measures ANOVA analysis was used for formulation optimization. αTS-PTX-NLC and αTS-PTX-PEG-NLC had a mean particle size, polydispersity index and zeta potential …


Essential Oil Yield, Composition, And Bioactivity Of Sagebrush Species In The Bighorn Mountains, Valtcho D. Zheljazkov, Charles L. Cantrell, Ekaterina A. Jeliazkova, Tess Astatkie May 2022

Essential Oil Yield, Composition, And Bioactivity Of Sagebrush Species In The Bighorn Mountains, Valtcho D. Zheljazkov, Charles L. Cantrell, Ekaterina A. Jeliazkova, Tess Astatkie

Faculty and Student Publications

Sagebrush (Artemisia spp.) are dominant wild plants in large areas of the U.S., Canada and Mexico, and they include several species and subspecies. The aim was to determine if there are significant differences in essential oil (EO) yield, composition, and biological activity of sagebrush within the Bighorn Mountains, U.S. The EO yield in fresh herbage varied from 0.15 to 1.69% for all species, including 0.25–1.69% in A. tridentata var. vaseyana, 0.64–1.44% in A. tridentata var. tridentata, 1% in A. tridentata var. wyomingensis, 0.8–1.2% in A. longifolia, 0.8–1% in A. cana, and 0.16% in A. ludoviciana. There was significant variability in …


Fractionation Of Sulfated Galactan From The Red Alga Botryocladia Occidentalis Separates Its Anticoagulant And Anti-Sars-Cov-2 Properties, Seon Beom Kim, Mary Zoepfl, Priyanka Samanta, Fuming Zhang May 2022

Fractionation Of Sulfated Galactan From The Red Alga Botryocladia Occidentalis Separates Its Anticoagulant And Anti-Sars-Cov-2 Properties, Seon Beom Kim, Mary Zoepfl, Priyanka Samanta, Fuming Zhang

Faculty and Student Publications

Sulfation pattern and molecular weight (MW) play a key role in the biological actions of sulfated glycans. Besides anticoagulant effects, certain sulfated glycans can also exhibit anti-SARS-CoV-2 properties. To develop a more selective antiviral carbohydrate, an efficient strategy to separate these two actions is required. In this work, low MW fractions derived from the red alga Botryocladia occidentalis sulfated galactan (BoSG) were generated, structurally characterized, and tested for activity against SARS-CoV-2 and blood coagulation. The lowest MW fraction was found to be primarily composed of octasaccharides of monosulfated monosaccharides. Unlike heparin or native BoSG, we found that hydrolyzed BoSG products …


A Simple, Cost-Effective, And Green Hptlc Method For The Estimation Of Ascorbic Acid In Solvent And Ultrasound-Assisted Extracts Of Phyllanthus Emblica, Capsicum Annuum, And Psidium Guajava, Ahmed I. Foudah, Prawez Alam, Faiyaz Shakeel, Aftab Alam May 2022

A Simple, Cost-Effective, And Green Hptlc Method For The Estimation Of Ascorbic Acid In Solvent And Ultrasound-Assisted Extracts Of Phyllanthus Emblica, Capsicum Annuum, And Psidium Guajava, Ahmed I. Foudah, Prawez Alam, Faiyaz Shakeel, Aftab Alam

Faculty and Student Publications

Greener analytical methodologies for the estimation of ascorbic acid (AA) are poorly reported in the literature. Furthermore, the green indexes of the literature’s analytical assays of AA estimation have not been assessed. As a consequence, the aim of this research is to invent and validate a simple, cost-effective, and green reverse-phase “high-performance thin-layer chromatography (HPTLC)” method for the estimating AA in the solvent extracts (SE) and ultrasound-assisted extracts (UAE) of Phyllanthus emblica, Psidium guajava, and Capsicum annuum. The greener mobile phase for AA estimation was a binary mixture of water and ethanol (70:30, v/v). At a wavelength of 265 nm, …


Rap1a Activity Elevated The Impact Of Endogenous Ages In Diabetic Collagen To Stimulate Increased Myofibroblast Transition And Oxidative Stress, Stephanie D. Burr, Christopher C. Dorroh, James A. Stewart May 2022

Rap1a Activity Elevated The Impact Of Endogenous Ages In Diabetic Collagen To Stimulate Increased Myofibroblast Transition And Oxidative Stress, Stephanie D. Burr, Christopher C. Dorroh, James A. Stewart

Faculty and Student Publications

Diabetics have an increased risk for heart failure due to cardiac fibroblast functional changes occurring as a result of AGE/RAGE signaling. Advanced glycation end products (AGEs) levels are higher in diabetics and stimulate elevated RAGE (receptor for AGE) signaling. AGE/RAGE signaling can alter the expression of proteins linked to extracellular matrix (ECM) remodeling and oxidative stressors. Our lab has identified a small GTPase, Rap1a, that may overlap the AGE/RAGE signaling pathway. We sought to determine the role Rap1a plays in mediating AGE/RAGE changes and to assess the impact of isolated collagen on further altering these changes. Primary cardiac fibroblasts from …


Selective Inhibition Of Plasmodium Falciparum Atpase 6 By Artemisinins And Identification Of New Classes Of Inhibitors After Expression In Yeast, Catherine M. Moore, Jigang Wang, Qingsong Lin, Pedro Ferreira May 2022

Selective Inhibition Of Plasmodium Falciparum Atpase 6 By Artemisinins And Identification Of New Classes Of Inhibitors After Expression In Yeast, Catherine M. Moore, Jigang Wang, Qingsong Lin, Pedro Ferreira

Faculty and Student Publications

Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work. Here, we report the successful development of a heterologous expression-based compoundscreening tool. The validated drug target Plasmodium falciparum ATPase 6 (PfATP6) and a mammalian orthologue (sarco/endoplasmic reticulum calcium ATPase 1a [SERCA1a]) were functionally expressed in Saccharomyces cerevisiae, providing a robust, sensitive, and specific screening tool. Whole-cell and in vitro assays consistently demonstrated inhibition and labeling of PfATP6 by artemisinins. Mutations in PfATP6 resulted in fitness costs that were …


Attitudes Toward The U. S. Medical Care System And Covid-19 Vaccines: What Do We Know About The College-Aged Population?, Jinting Guo May 2022

Attitudes Toward The U. S. Medical Care System And Covid-19 Vaccines: What Do We Know About The College-Aged Population?, Jinting Guo

Honor Scholar Theses

To understand the attitude of the college-age population towards the U.S. medical care system, the researcher conducted an online survey study with 296 participants. By calculating Pearson’s r correlation coefficient, the researcher found the more positive one’s past experience with the U.S. medical care system, the more positive one’s general attitudes toward the U.S. medical care system. In addition, one’s trust level in COVID-19 vaccines was found to be correlated with one’s level of trust in the U.S. medical care system. What’s more, online information was identified by the majority of the participants as a factor influenced their attitudes toward …


Code Blue! When A Simulation Isn’T A Simulation Anymore, Bethany Rocheleau, Christine Mallar, Shelly Chipman, Leah Mallory, Mike Shepherd, Erin Siebers, Susan Lane, Tracie Knight May 2022

Code Blue! When A Simulation Isn’T A Simulation Anymore, Bethany Rocheleau, Christine Mallar, Shelly Chipman, Leah Mallory, Mike Shepherd, Erin Siebers, Susan Lane, Tracie Knight

Costas T. Lambrew Research Retreat 2022

Objectives:

• To identify and remediate gaps responding to a medical emergency during a simulated event.

• To provide a safe working environment for standardized patients and clinical staff.


The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen May 2022

The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen

Honors College Theses

The percent of people with mental health disorders in the United States have skyrocketed over the past decade. With stigma surrounding the discussion of mental health and the symptoms associated with it, often those that are suffering do not receive sufficient treatment, as they might with a physical illness. The current, common treatment options for common psychological disorders, like depression, anxiety, and post-traumatic stress disorder, are sometimes not effective in patients, due to resistance or poor response outcomes. Consequently, in order to research alternative therapeutic approaches for mental health disorders, scientists are researching the effects of several hallucinogenic drugs in …


First Generation Filipino Children And The Risk Of Childhood Obesity: Influence Of Screen Time, Krystal Joy Joy Ragasa May 2022

First Generation Filipino Children And The Risk Of Childhood Obesity: Influence Of Screen Time, Krystal Joy Joy Ragasa

Nursing | Senior Theses

Background: Obesity is an epidemic in the United States and among all Asian subgroups, Filipinos are particularly at a much higher risk. Obesity raises the risk of acquiring other health complications, especially for those who develop obesity at a younger age. Research has shown that children who engage in higher levels of screen time are more likely to become obese, resulting in screen time restrictions and recommendations. Additionally, rates of obesity are higher in immigrants. There is a gap in the explanation of screen time’s effect on childhood obesity for first generation Filipino children.

Aim: The purpose of the proposed …


Novel Regulators Of Cellular Secretion Alter The Tumor Microenvironment To Drive Metastasis, Rakhee Bajaj May 2022

Novel Regulators Of Cellular Secretion Alter The Tumor Microenvironment To Drive Metastasis, Rakhee Bajaj

Dissertations & Theses (Open Access)

Lung cancer is a highly aggressive disease responsible for ~25% of all cancer-related deaths, due in part to its proclivity to metastasize. Treating metastasis holds potential for improving patient survival but requires a deeper investigation into the underlying mechanisms. Some of these processes that can regulate metastasis are: (1) Oncogenic targets of epithelial micro-RNAs (miRNAs) are epigenetically de-repressed upon loss of the miRNAs during epithelial-to-mesenchymal transition (EMT) and in cancer. EMT confers plasticity and fitness to cancer cells promoting their survival through the metastatic cascade. This cascade and EMT are initiated by loss of the miRNA200 family (miR-200) and the …


Parental Stress In Tuberous Sclerosis Complex, Jenny Do May 2022

Parental Stress In Tuberous Sclerosis Complex, Jenny Do

Dissertations & Theses (Open Access)

Tuberous Sclerosis Complex (TSC) is a multi-systemic genetic disorder with great clinical variability. As the needs of one child with TSC may vastly differ from another, parenting demands may similarly differ. Characterizing parental stress, or emotional maladaptation arising from parenting duties, can enable healthcare providers to assist parents of children most efficiently with TSC-related symptoms and improve both parent and child health outcomes. This study surveyed 269 parents of children (aged 0-12 years) with TSC and received the following information: children’s TSC clinical features, parent demographics, and a Parent Stress Index (PSI) score. Parents reported higher stress levels for children …


Prenatal Testing Decisions And Motivations In Pregnancies Conceived Via In Vitro Fertilization, Michelle Appel May 2022

Prenatal Testing Decisions And Motivations In Pregnancies Conceived Via In Vitro Fertilization, Michelle Appel

Dissertations & Theses (Open Access)

Currently, there is limited information about how conceiving through in vitro fertilization (IVF) and preimplantation genetic testing for aneuploidy (PGT-A) impact the decisions individuals make about prenatal genetic testing. This quantitative study aimed to examine the prenatal testing decisions made by pregnant individuals who conceived via IVF as well as to compare the prenatal testing decisions and motivations between those who had PGT-A and those who did not. An anonymous survey was distributed through online support forums and in clinical settings to eligible individuals. Overall, 230 complete responses were collected with 203 participants far enough along in pregnancy to make …