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2012

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Articles 1 - 30 of 10961

Full-Text Articles in Medicine and Health Sciences

A Haven Of Last Resort: The Consequences Of Evacuating Florida Nursing Home Residents To Nonclinical Buildings, Janelle Christensen Sep 2014

A Haven Of Last Resort: The Consequences Of Evacuating Florida Nursing Home Residents To Nonclinical Buildings, Janelle Christensen

Janelle J. Christensen

Nursing home administrators (n = 15) and directors of nursing (n = 15) who worked in nursing homes during the 2004–2005 Florida hurricane season participated in a series of 6 focus groups. The purpose of the focus groups was to explore issues faced by nursing home administrators, nurses, and residents during hurricane evacuations. A primary finding was that evacuating nursing home residents to buildings that are not designed to support nursing activities (e.g., a school gymnasium or church) adversely affected resident feeding, sleeping, movement, and security. These nonclinical buildings also presented serious occupational health concerns for nursing staff members who ...


Home Care Nurses' Experience Of Job Stress And Considerations For The Work Environment, Linda Samia, Carol Ellenbecker, Donna Friedman, Karen Dick Oct 2013

Home Care Nurses' Experience Of Job Stress And Considerations For The Work Environment, Linda Samia, Carol Ellenbecker, Donna Friedman, Karen Dick

Donna Haig Friedman

No abstract provided.


Results Of The National Council Of State Boards Of Nursing National Simulation Survey: Part Ii, Suzan Kardong-Edgren, Janet Willhaus, Deborah Bennett, Jennifer Hayden Aug 2013

Results Of The National Council Of State Boards Of Nursing National Simulation Survey: Part Ii, Suzan Kardong-Edgren, Janet Willhaus, Deborah Bennett, Jennifer Hayden

Janet Willhaus

Background: The purpose of this article is to report additional data gathered during the National Council of State Boards of Nursing 2010 nationwide simulation survey of 1,729 nursing programs in the United States. It serves as a companion article to the initial survey data reported by Hayden in 2010.

Method: All prelicensure nursing programs in the United States were mailed the survey; 62% of programs (N ¼ 1,060) receiving the survey responded. This article presents respondents’ answers to an additional eight questions about a program’s use of simulation and thoughts on various aspects of simulation, not reported ...


Evaluation Of Mast Cells In Dermal Versus Subcutaneous Hemangiomas And Hemangiosarcomas In Dogs, Ann Reed, Katherine Barber, Kim Newkirk, Robert Donnell Jul 2013

Evaluation Of Mast Cells In Dermal Versus Subcutaneous Hemangiomas And Hemangiosarcomas In Dogs, Ann Reed, Katherine Barber, Kim Newkirk, Robert Donnell

Kim M Newkirk

No abstract provided.


Pot-Bellied Pig Neoplasia: A Retrospective Case Series (2004-2011), Shelley Newman, Barton Rohrbach Jun 2013

Pot-Bellied Pig Neoplasia: A Retrospective Case Series (2004-2011), Shelley Newman, Barton Rohrbach

Barton W Rohrbach Dr.

The current report summarizes the incidence and variety of neoplasms in pot-bellied pigs as documented by the pathology group at the University of Tennessee, College of Veterinary Medicine (UTCVM) between 2004 and 2011. Sixty-three pot-bellied pig cases (53 necropsies and 10 surgical biopsies) were identified from the UTCVM case database. Of these, 22 cases from 21 patients (34.9%) were given a diagnosis of neoplasia, including 10 females, 3 spayed females, 2 males, and 7 neutered males. The mean age of affected animals was 11.3 years. The incidence of neoplasia among the necropsy cases was 28% (15/53), and ...


Detection Of Dichloromethane With A Bioluminescent (Lux) Bacterial Bioreporter, Nicholas Lopes, Shawn Hawkins, Patricia Jegier, Fu-Min Menn, Gary Sayler, Steven Ripp Jun 2013

Detection Of Dichloromethane With A Bioluminescent (Lux) Bacterial Bioreporter, Nicholas Lopes, Shawn Hawkins, Patricia Jegier, Fu-Min Menn, Gary Sayler, Steven Ripp

Gary S. Sayler

The focus of this research effort was to develop an autonomous, inducible, lux-based bioluminescent bioreporter for the real-time detection of dichloromethane. Dichloromethane (DCM), also known as methylene chloride, is a volatile organic compound and one of the most commonly used halogenated solvents in the U.S., with applications ranging from grease and paint stripping to aerosol propellants and pharmaceutical tablet coatings. Predictably, it is released into the environment where it contaminates air and water resources. Due to its classification as a probable human carcinogen, hepatic toxin, and central nervous system effector, DCM must be carefully monitored and controlled. Methods for ...


The Influence Of Local Food Environments On Adolescents’ Food Purchasing Behaviors, Meizi He, Patricia Tucker, Jason Gilliland, Jennifer Irwin, Kristian Larsen, Paul Hess May 2013

The Influence Of Local Food Environments On Adolescents’ Food Purchasing Behaviors, Meizi He, Patricia Tucker, Jason Gilliland, Jennifer Irwin, Kristian Larsen, Paul Hess

Trish Tucker

This study examined the relationship between the neighborhood food environment and the food purchasing behaviors among adolescents. Grade 7 and 8 students (n = 810) at 21 elementary schools in London, Ontario, Canada completed a questionnaire assessing their food purchasing behaviors. Parents of participants also completed a brief questionnaire providing residential address and demographic information. A Geographic Information System (GIS) was used to assess students’ home and school neighborhood food environment and land use characteristics. Logistic regression analysis was conducted to assess the influence of the home neighborhood food environment on students’ food purchasing behaviors, while two-level Hierarchical Non-Linear Regression Models ...


Preclinical Single-Dose Safety And Pharmacokinetic Evaluation Of Fluorocoxib A: Pilot Study Of Novel Cyclooxygenase-2-Targeted Optical Imaging Agent In A Canine Model, Maria Cekanova, M Uddin, Alfred Legendre, Gina Gaylon, Joseph Bartges, Amanda Callens, L Marnett May 2013

Preclinical Single-Dose Safety And Pharmacokinetic Evaluation Of Fluorocoxib A: Pilot Study Of Novel Cyclooxygenase-2-Targeted Optical Imaging Agent In A Canine Model, Maria Cekanova, M Uddin, Alfred Legendre, Gina Gaylon, Joseph Bartges, Amanda Callens, L Marnett

Alfred M Legendre DVM, MS, DACVIM

We evaluated preclinical single-dose safety, pharmacokinetic properties, and specific uptake of the new optical imaging agent fluorocoxib A in dogs. Fluorocoxib A, N-[(5-carboxy-X-rhodaminyl)but-4-yl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide, selectively binds and inhibits the cyclooxygenase-2 (COX-2) enzyme, which is overexpressed in many cancers. Safety pilot studies were performed in research dogs following intravenous (i.v.) administration of 0.1 and 1  mg/kg fluorocoxib A. Blood and urine samples collected three days after administration of each dose of fluorocoxib A revealed no evidence of toxicity, and no clinically relevant adverse events were noted on physical examination of exposed dogs ...


Antinociceptive Effects After Oral Administration Of Tramadol Hydrochloride In Hispaniolan Amazon Parrots (Amazona Ventralis), Marcy Souza, David Guzman, Joanne Paul-Murphy, Sherry Cox, N Keuhler, J Brown May 2013

Antinociceptive Effects After Oral Administration Of Tramadol Hydrochloride In Hispaniolan Amazon Parrots (Amazona Ventralis), Marcy Souza, David Guzman, Joanne Paul-Murphy, Sherry Cox, N Keuhler, J Brown

Sherry Cox

OBJECTIVE: To determine the antinociceptive and sedative effects of tramadol in Hispaniolan Amazon parrots (Amazona ventralis) following IV administration. ANIMALS: 11 healthy Hispaniolan Amazon parrots of unknown sex. PROCEDURES: Tramadol hydrochloride (5 mg/kg, IV) and an equivalent volume (≤ 0.34 mL) of saline (0.9% NaCl) solution were administered to parrots in a complete crossover study design. Foot withdrawal response to a thermal stimulus was determined 30 to 60 minutes before (baseline) and 15, 30, 60, 120, and 240 minutes after treatment administration; agitation-sedation scores were determined for parrots at each of those times. RESULTS: The estimated mean changes ...


What Is Your Diagnosis? Skull Fracture In A Foal, J Anderson, Silke Hecht, Karen Mccormick Apr 2013

What Is Your Diagnosis? Skull Fracture In A Foal, J Anderson, Silke Hecht, Karen Mccormick

Silke Hecht

No abstract provided.


Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius)., Ricardo Videla, Sarel Van Amstel, Sarah O'Neill, Linda Frank, Shelley Newman, Raquel Vilela, Leonel Mendoza Apr 2013

Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius)., Ricardo Videla, Sarel Van Amstel, Sarah O'Neill, Linda Frank, Shelley Newman, Raquel Vilela, Leonel Mendoza

Shelley Newman

Two camels (Camelus dromedarius), 3- and 4-years-old, respectively, from an eastern Tennessee wildlife farm presented with persistent weight loss and large vulvar masses. An initial biopsy of the vulvar mass of one of the camels performed by a local veterinarian showed eosinophilic dermatitis. An allergic or parasitic dermatitis was suspected. The two camels were treated with one dose of sodium iodide (66 mg/kg, in 1.0 L of normosolR, IV) and ivermectin 1% (200 ug/kg PO). Upon presentation at the Veterinary Teaching Hospital, University of Tennessee, additional biopsies of the masses again revealed eosinophilic dermatitis. Microscopic examination of ...


Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius), Ricardo Videla, Sarel Van Amstel, Linda Frank, Sherry Newman, Raquel Vilela, L Mendoza Apr 2013

Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius), Ricardo Videla, Sarel Van Amstel, Linda Frank, Sherry Newman, Raquel Vilela, L Mendoza

Sarel R Van Amstel BVSc, Dip Med Vet, M MED VET, DACVIM

Two camels (Camelus dromedarius), 3- and 4-years-old, respectively, from an eastern Tennessee wildlife farm presented with persistent weight loss and large vulvar masses. An initial biopsy of the vulvar mass of one of the camels performed by a local veterinarian showed eosinophilic dermatitis. An allergic or parasitic dermatitis was suspected. The two camels were treated with one dose of sodium iodide (66 mg/kg, in 1.0 L of normosolR, IV) and ivermectin 1% (200 ug/kg PO). Upon presentation at the Veterinary Teaching Hospital, University of Tennessee, additional biopsies of the masses again revealed eosinophilic dermatitis. Microscopic examination of ...


Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius), Ricardo Videla, Sarel Van Amstel, Linda Frank, Sherry Newman, Raquel Vilela, L Mendoza Apr 2013

Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius), Ricardo Videla, Sarel Van Amstel, Linda Frank, Sherry Newman, Raquel Vilela, L Mendoza

Ricardo Videla DVM, DACVIM, College of Veterinary Medicine

Two camels (Camelus dromedarius), 3- and 4-years-old, respectively, from an eastern Tennessee wildlife farm presented with persistent weight loss and large vulvar masses. An initial biopsy of the vulvar mass of one of the camels performed by a local veterinarian showed eosinophilic dermatitis. An allergic or parasitic dermatitis was suspected. The two camels were treated with one dose of sodium iodide (66 mg/kg, in 1.0 L of normosolR, IV) and ivermectin 1% (200 ug/kg PO). Upon presentation at the Veterinary Teaching Hospital, University of Tennessee, additional biopsies of the masses again revealed eosinophilic dermatitis. Microscopic examination of ...


What Is Your Diagnosis? Extraskeletal Osteosarcoma In A Dog, S Mackenzie, Silke Hecht, Patricia Sura, Linden Craig Mar 2013

What Is Your Diagnosis? Extraskeletal Osteosarcoma In A Dog, S Mackenzie, Silke Hecht, Patricia Sura, Linden Craig

Silke Hecht

No abstract provided.


Equine Peripheral Blood-Derived Mesenchymal Stem Cells: Isolation, Identification, Trilineage Differentiation And Effect Of Hyperbaric Oxygen Treatment, Madhu Dhar, Nancy Neilsen, K Beatty, S Eaker, Henry Adair, Dennis Geiser Feb 2013

Equine Peripheral Blood-Derived Mesenchymal Stem Cells: Isolation, Identification, Trilineage Differentiation And Effect Of Hyperbaric Oxygen Treatment, Madhu Dhar, Nancy Neilsen, K Beatty, S Eaker, Henry Adair, Dennis Geiser

Dennis R. Geiser DVM, DAVBP

REASONS FOR PERFORMING STUDY: Two studies report variability in proliferation and limited adipocyte differentiation of equine peripheral blood-derived adult mesenchymal stem cells, thus casting doubt on their adipogenic potential. Peripheral blood can be a valuable source of adult mesenchymal stem cells if cell culture conditions permissive for their adherence, proliferation and differentiation are defined. Hyperbaric oxygen treatment has been reported to mobilise haematopoietic progenitor stem cells into the peripheral blood in humans and mice, but similar experiments have not been done in horses. OBJECTIVES: To optimise cell culture conditions for isolation, propagation and differentiation of adult stem cells from peripheral ...


Socioeconomic Determinants Of Geographic Disparities In Campylobacteriosis Risk: A Comparison Of Global And Local Modeling Approaches, Jennifer Weisent, Barton Rohrbach, John Dunn, Agricola Odoi Feb 2013

Socioeconomic Determinants Of Geographic Disparities In Campylobacteriosis Risk: A Comparison Of Global And Local Modeling Approaches, Jennifer Weisent, Barton Rohrbach, John Dunn, Agricola Odoi

Barton W Rohrbach Dr.

Background: Socioeconomic factors play a complex role in determining the risk of campylobacteriosis. Understanding the spatial interplay between these factors and disease risk can guide disease control programs. Historically, Poisson and negative binomial models have been used to investigate determinants of geographic disparities in risk. Spatial regression models, which allow modeling of spatial effects, have been used to improve these modeling efforts. Geographically weighted regression (GWR) takes this a step further by estimating local regression coefficients, thereby allowing estimations of associations that vary in space. These recent approaches increase our understanding of how geography influences the associations between determinants and ...


Equine Peripheral Blood-Derived Mesenchymal Stem Cells: Isolation, Identification, Trilineage Differentiation And Effect Of Hyperbaric Oxygen Treatment, Madhu Dhar, Nancy Neilsen, K Beatty, S Eaker, Henry Adair, Dennis Geiser Feb 2013

Equine Peripheral Blood-Derived Mesenchymal Stem Cells: Isolation, Identification, Trilineage Differentiation And Effect Of Hyperbaric Oxygen Treatment, Madhu Dhar, Nancy Neilsen, K Beatty, S Eaker, Henry Adair, Dennis Geiser

Henry S. Adair, III MS, DVM, DACVS

REASONS FOR PERFORMING STUDY: Two studies report variability in proliferation and limited adipocyte differentiation of equine peripheral blood-derived adult mesenchymal stem cells, thus casting doubt on their adipogenic potential. Peripheral blood can be a valuable source of adult mesenchymal stem cells if cell culture conditions permissive for their adherence, proliferation and differentiation are defined. Hyperbaric oxygen treatment has been reported to mobilise haematopoietic progenitor stem cells into the peripheral blood in humans and mice, but similar experiments have not been done in horses. OBJECTIVES: To optimise cell culture conditions for isolation, propagation and differentiation of adult stem cells from peripheral ...


Evaluation Of Cefoxitin Disk Diffusion Breakpoint For Detection Of Methicillin Resistance In Staphylococcus Pseudintermedius Isolates From Dogs, David Bemis, R Jones, Ricardo Videla, Stephen Kania Jan 2013

Evaluation Of Cefoxitin Disk Diffusion Breakpoint For Detection Of Methicillin Resistance In Staphylococcus Pseudintermedius Isolates From Dogs, David Bemis, R Jones, Ricardo Videla, Stephen Kania

Stephen A Kania

Cefoxitin disk diffusion susceptibility testing is a recommended screening method for the detection of methicillin resistance in human isolates of Staphylococcus aureus and coagulase-negative staphylococci. A retrospective analysis of 1,146 clinical isolates of Staphylococcus pseudintermedius from dogs was conducted to determine if screening by the cefoxitin disk method can be similarly useful with S. pseudintermedius. The distribution of cefoxitin growth inhibition zone diameters within this collection was bimodal and correlated well with the results of methicillin resistance gene (mecA) detection by polymerase chain reaction. Of the isolates, 5% had discordant results and, when retested, 84% of these were in ...


The Change Program: Comparing An Interactive Versus Standardized Obesity Intervention On Students' Self-Esteem, Functional Health Status And Self-Efficacy For Performing Physical Activity And Nutrition Behaviours, Erin Pearson, Jennifer Irwin, Don Morrow Jan 2013

The Change Program: Comparing An Interactive Versus Standardized Obesity Intervention On Students' Self-Esteem, Functional Health Status And Self-Efficacy For Performing Physical Activity And Nutrition Behaviours, Erin Pearson, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.


Health Care Practitioners’ Perceptions Of Motivational Interviewing Training For Facilitating Behavior Change Among Patients, Erin Wiley, Jennifer Irwin, Don Morrow Jan 2013

Health Care Practitioners’ Perceptions Of Motivational Interviewing Training For Facilitating Behavior Change Among Patients, Erin Wiley, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.


The Level Of Cultural Responsiveness And Its Preparation Among Grand Valley State University’S Occupational Therapy Graduates, Kathleen Kovach, Rebecca Palmitier, Robyn Ward Dec 2012

The Level Of Cultural Responsiveness And Its Preparation Among Grand Valley State University’S Occupational Therapy Graduates, Kathleen Kovach, Rebecca Palmitier, Robyn Ward

Education

Background: In a field that aims to be holistic and client-centered, occupational therapists need to consider their client's culture. Culture is comprised of values, beliefs, and lifestyles and will affect the therapy process (Cheung, Shah, & Muncer, 2002; Cole, Stevenson, & Rogers, 2009). To truly treat clients holistically, therapists need to be culturally responsive in their practice, considering factors which influence therapy and its outcomes. Occupational therapy education programs, therefore, need to prepare its students to be culturally responsive practitioners. This research examined whether Grand Valley State University (GVSU) Occupational Therapy (OT) graduates are culturally responsive and how the program is preparing them in this area

Method: A mixed-methods study that utilized a concurrent triangulation strategy was used. A questionnaire with close-ended, Likert-type scale questions and an open-ended question was used to gather data. The questionnaire consisted of the Cultural Awareness and Sensitivity Questionnaire (Cheung et al., 2002) and researcher developed questions that were specific to GVSU's OT program. The questionnaire was sent to 148 GVSU OT graduates through an online survey tool (SurveyGizmo); 45 participants responded.

Results: Results showed that only 17.1% of graduates were fully culturally responsive; yet the majority had higher levels of cultural responsiveness. Graduates reported that both classroom experiences and fieldwork increased their cultural responsiveness, and more believed that fieldwork had an impact on their cultural responsiveness than classroom experiences. The qualitative results support this as well. Some graduates reported ...


Formative Development Of A Culturally Appropriate Mammography Screening Campaign For Low-Income African-American Women., Kimberly D. Leeks, Ingrid J. Hall, C. Ashani Johnson-Turbes, Ngozi Kamalu, Yasmine Zavahir Dec 2012

Formative Development Of A Culturally Appropriate Mammography Screening Campaign For Low-Income African-American Women., Kimberly D. Leeks, Ingrid J. Hall, C. Ashani Johnson-Turbes, Ngozi Kamalu, Yasmine Zavahir

Journal of Health Disparities Research and Practice

The purpose of this qualitative study was to conduct a formative evaluation of messages and materials to inform the development of a promotional, health campaign designed to increase breast cancer screening awareness and utilization among low-income, uninsured African American women through the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) in Savannah and Macon, Georgia (GA). A priority of CDC is to understand why women eligible for screening through the NBCCEDP do not participate in NBCCEDP screening services as well as to identify effective strategies for increasing enrollment among NBCCEDP-eligible women who have never received breast cancer screening. As ...


Ethnic And Gender Differences In Psychosocial Factors In Native Hawaiian, Other Pacific Islanders, And Asian American Adults With Type 2 Diabetes, Jillian Inouye, Dongmei Li, James Davis, Richard Arakaki Dec 2012

Ethnic And Gender Differences In Psychosocial Factors In Native Hawaiian, Other Pacific Islanders, And Asian American Adults With Type 2 Diabetes, Jillian Inouye, Dongmei Li, James Davis, Richard Arakaki

Journal of Health Disparities Research and Practice

This study examined the differences between 207 Asians and Native Hawaiian, other Pacific Islanders (NHOPI) with type 2 diabetes among various psychosocial measures. Responses to five multivariable regression models including the Diabetes Quality of Life Questionnaire (DQOL) and Short Form -36® Health Survey (SF-36) were analyzed. Differences were determined by linear contrasts in the multivariate linear regression models after adjusted for multiple demographic and socioeconomic variables. Compared to Asians, NHOPIs perceived a lower impact of diabetes on their quality of life; highlighting differences in perceptions of self-efficacy and self-care activities. Females did better on their diet while males perceived better ...


Housing, The Neighborhood Environment, And Physical Activity Among Older African Americans, Lonnie Hannon Iii, Patricia Sawyer, Richard M. Allman Dec 2012

Housing, The Neighborhood Environment, And Physical Activity Among Older African Americans, Lonnie Hannon Iii, Patricia Sawyer, Richard M. Allman

Journal of Health Disparities Research and Practice

Abstract

This study examines the association of neighborhood environment, as measured by housing factors, with physical activity among older African Americans. Context is provided on the effects of structural inequality as an inhibitor of health enhancing neighborhood environments. The study population included African Americans participating in the UAB Study of Aging (n=433). Participants demonstrated the ability to walk during a baseline in-home assessment. The strength and independence of housing factors were assessed using neighborhood walking for exercise as the outcome variable. Sociodemographic data, co-morbid medical conditions, and rural/urban residence were included as independent control factors. Homeownership, occupancy, and ...


Racial Disparities In Pain Management In Primary Care, Miriam Ezenwa Dec 2012

Racial Disparities In Pain Management In Primary Care, Miriam Ezenwa

Journal of Health Disparities Research and Practice

This descriptive, cross-sectional, secondary data analysis was conducted to examine racial disparities in pain management of primary care patients with chronic nonmalignant pain using chronic opioid therapy. Data from 891 patients, including 201 African Americans and 691 Caucasians were used to test an explanatory model for these disparities. We predicted that: (1) African American patients would report worse pain management and poor quality of life (QOL) than Caucasians; (2) the association between race and pain management would be mediated by perceived discrimination relating to hopelessness; and (3) poor pain management would negatively affect QOL. Results revealed significant differences between African ...


Potentials And Limitations Of Real-Time Elastography For Prostate Cancer Detection: A Whole-Mount Step Section Analysis., Daniel Junker, Georg Schäfer, Friedrich Aigner, Peter Schullian, Leo Pallwein-Prettner, Jasmin Bektic, Wolfgang Horninger, Ethan J Halpern, Ferdinand Frauscher Dec 2012

Potentials And Limitations Of Real-Time Elastography For Prostate Cancer Detection: A Whole-Mount Step Section Analysis., Daniel Junker, Georg Schäfer, Friedrich Aigner, Peter Schullian, Leo Pallwein-Prettner, Jasmin Bektic, Wolfgang Horninger, Ethan J Halpern, Ferdinand Frauscher

Department of Radiology Faculty Papers

OBJECTIVES: To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type.

MATERIALS AND METHODS: Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates.

RESULTS: RTE detected 6/62 cancer lesions with a maximum diameter of 0-5 mm (9.7%), 10/37 with a maximum diameter of 6-10 mm (27%), 24/34 ...


Earth Is (Mostly) Flat: Apportionment Of The Flux Of Continental Sediment Over Millennial Time Scales, Jane K. Willenbring, Alexandru T. Codilean, Brandon Mcelroy Dec 2012

Earth Is (Mostly) Flat: Apportionment Of The Flux Of Continental Sediment Over Millennial Time Scales, Jane K. Willenbring, Alexandru T. Codilean, Brandon Mcelroy

Faculty of Science, Medicine and Health - Papers: part A

We use a new compilation of global denudation estimates from cosmogenic nuclides to calculate the apportionment and the sum of all sediment produced on Earth by extrapolation of a statistically significant correlation between denudation rates and basin slopes to watersheds without denudation rate data. This robust relationship can explain approximately half of the variance in denudation from quartz-bearing topography drained by rivers using only mean slopes as the predictive tool and matches a similar fit for large river basins. At slopes >200 m/km, topography controls denudation rates. Controls on denudation in landscapes where average slopes are 10 mm/k ...


Successfully Climbing The "Stairs": Surmounting Failed Translation Of Experimental Ischemic Stroke Treatments, Michael Kahle, Gregory J. Bix Dec 2012

Successfully Climbing The "Stairs": Surmounting Failed Translation Of Experimental Ischemic Stroke Treatments, Michael Kahle, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation ...


Regulation Of The Mouse And Human Β-Globin Genes By Krüppel Like Transcription Factors Klf1 And Klf2, Yousef N. Alhashem Dec 2012

Regulation Of The Mouse And Human Β-Globin Genes By Krüppel Like Transcription Factors Klf1 And Klf2, Yousef N. Alhashem

Theses and Dissertations

Krüppel-like factors KLF1 and KLF2 are closely related transcription factors with three zinc finger domains in their carboxy-termini. KLF1 (erythroid Krüppel-like factor, or EKLF) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic β- globin genes. KLF1 and KLF2 have overlapping roles in embryonic erythropoiesis, as demonstrated using single and double knockout (KO) mouse models. Ablation of the KLF1 or KLF2 gene causes embryonic lethality, and double KO embryos are more anemic and die sooner than either single KO. We have shown that KLF1 and KLF2 positively regulate the human ...


Commentary By Williams, Kristine Williams Dec 2012

Commentary By Williams, Kristine Williams

Kristine N. Williams

No abstract provided.