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Full-Text Articles in Medicine and Health Sciences

Structure And Function Of Asthma Evaluated Using Pulmonary Imaging, Rachel L. Eddy Apr 2020

Structure And Function Of Asthma Evaluated Using Pulmonary Imaging, Rachel L. Eddy

Electronic Thesis and Dissertation Repository

Asthma has been understood to affect the airways in a spatially heterogeneous manner for over six decades. Computational models of the asthmatic lung have suggested that airway abnormalities are diffusely and randomly distributed throughout the lung, however these mechanisms have been challenging to measure in vivo using current clinical tools. Pulmonary structure and function are still clinically characterized by the forced expiratory volume in one-second (FEV1) – a global measurement of airflow obstruction that is unable to capture the underlying regional heterogeneity that may be responsible for symptoms and disease worsening. In contrast, pulmonary magnetic resonance imaging (MRI) provides a ...


The Symbiome Project: An Exploratory Investigation Of The Biological, Psychological, And Social Mechanisms That Contribute To The Transition From Acute To Chronic Musculoskeletal Pain, Joshua Y. Lee Apr 2020

The Symbiome Project: An Exploratory Investigation Of The Biological, Psychological, And Social Mechanisms That Contribute To The Transition From Acute To Chronic Musculoskeletal Pain, Joshua Y. Lee

Electronic Thesis and Dissertation Repository

This dissertation presents the initial findings of the SYMBIOME project; which attempts to combine the objective and subjective aspects of musculoskeletal pain to develop a prognostic clinical phenotype. Chapter 2 presents a moderator analysis of functional outcomes (pain interference and pain severity). Psychosocial moderators can affect the relationship between biomarkers and pain. For pain severity, TNF-α, TGF-β1, and CRP were moderated by employment status, pre-existing psychopathology, and sex. For pain interference, IL-1β, cortisol, TGF-β1, CRP, and IL-6 were moderated by pre-existing pain, peri-traumatic fear, region of injury, and peri-traumatic stress. Chapter 3 presents a latent growth curve analysis in determining ...


Developing And Evaluating The Integrated Addiction Recovery Model For The Persons' Engagement And Retention In The Recovery Process Among Clinical Populations From Rwanda, Boniface Harerimana Apr 2020

Developing And Evaluating The Integrated Addiction Recovery Model For The Persons' Engagement And Retention In The Recovery Process Among Clinical Populations From Rwanda, Boniface Harerimana

Electronic Thesis and Dissertation Repository

Background

To date, research that has investigated psychosocial processes and mechanisms, which underpin addiction recovery outcomes are scarce. This study sought to develop and test an integrated addiction recovery model for the recovery process while accounting for an individual’s psychosocial context.

Methods

This predictive study used consecutive sampling strategies to recruit 315 participants from tertiary addiction care settings in Rwanda. Data on the hypothesized model variables and individual’s characteristics were collected with self-reported measures. Structural equation modelling techniques were used to test the model psychometric measures and associations between latent variables.

Results

Baseline data analyses showed a mean ...


Assessment Of Intrinsic Hand Neuromuscular Physiology, Philemon Tsang Apr 2020

Assessment Of Intrinsic Hand Neuromuscular Physiology, Philemon Tsang

Electronic Thesis and Dissertation Repository

Alterations to the peripheral nervous system and neuromuscular physiology may impact hand function in a typical or clinical population, such as individuals with ulnar neuropathy. The mechanisms that influence these positive and negative changes are still not well understood. The three studies within my thesis aim to validate the reliability of decomposition-based quantitative electromyography (DQEMG) measurements and explore the changes in intrinsic hand neuromuscular physiology in a typical aging population and individuals recovering from a surgical intervention for severe ulnar neuropathy.

The purpose of the first study was to determine the test-retest reliability of near-fibre (NF) jiggle, a measure of ...


Kindness As An Intervention For Student Social Interaction Anxiety, Resilience, Affect, And Mood: The Kiss Of Kindness Study Ii, Katie J. Shillington Apr 2020

Kindness As An Intervention For Student Social Interaction Anxiety, Resilience, Affect, And Mood: The Kiss Of Kindness Study Ii, Katie J. Shillington

Electronic Thesis and Dissertation Repository

This research sought to assess the impact of deliberate acts of kindness (DAKs) plus access to a stress management booklet (intervention), compared to the booklet alone (control) on the stress-related outcomes of resilience, social interaction anxiety, affect, and mood of undergraduate and graduate students. Participants’ study-related experiences were explored, as were the types of DAKs. This repeated-measures, randomized controlled trial included 112 students (80 undergraduate and 32 graduate) with 56 in each condition. Four scales were implemented at baseline, immediate post-intervention, and 3-months post-intervention. A linear mixed effects model was utilized with group and time entered as fixed effects. Content ...


Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas Apr 2020

Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas

Electronic Thesis and Dissertation Repository

Otosclerosis is a relatively common hearing loss disorder characterized by abnormal bone growth in the otic capsule leading to stapes fixation. In approximately half of cases, otosclerosis is inherited as an autosomal dominant trait. Typically, gene discovery efforts rely on surgical confirmation, audiometry and occasionally acoustic reflexes to identify affected cases of otosclerosis within families, requiring that the otosclerosis was at an advanced stage to be detected. This makes it difficult to identify individuals with early otosclerosis. The use of advanced phenotyping to identify cases of otosclerosis was tested in an Ontario otosclerotic population as well as in two large ...


Hybrid Optical System For Studying The Dynamic Regulation Of Blood Flow/Metabolism In The Adult Brain, Marwan Shahid Apr 2020

Hybrid Optical System For Studying The Dynamic Regulation Of Blood Flow/Metabolism In The Adult Brain, Marwan Shahid

Electronic Thesis and Dissertation Repository

Cerebral blood flow (CBF) and oxygen delivery are tightly controlled to meet neuronal energy demands; however, studying dynamic neurovascular coupling in the human brain is challenging due to the lack of methods that can measure rapid changes in CBF and tissue oxygenation. This report presents an in-house-developed hybrid time-resolved near-infrared spectroscopy/diffuse correlation spectroscopy (TR-NIRS/DCS) device and its use to track dynamic CBF and tissue oxygen saturation (StO2) responses simultaneously with sub-second resolution following a vasodilatory stimulus (i.e., a hypercapnic challenge).

Cerebrovascular reactivity (CVR) experiments were performed on 10 healthy participants (mean age: 27 years) using a ...


Feasibility Of Post-Operative Mobile Health Monitoring Among Colorectal Surgery Patients, Tanya Kuper Mar 2020

Feasibility Of Post-Operative Mobile Health Monitoring Among Colorectal Surgery Patients, Tanya Kuper

Electronic Thesis and Dissertation Repository

Post-operative readmission following colorectal surgery is a common and costly occurrence. Remote health monitoring via mobile applications has the potential to reduce post-operative readmissions by early identification of complications. This intervention depends on patient acceptance and compliance with available technology. The feasibility of home monitoring using automated daily surveys and wound photo uploads, delivered via a mobile health application, was tested in the immediate post-operative period after colorectal surgery. Patient compliance, the association between generated alerts and readmissions, and patient satisfaction were measured. Patient satisfaction was high; 80.5% of patients reported that they felt safer going home knowing that ...


Patient Roles Within Interprofessional Collaborative Patient-Centred Care Teams: The Patient And Health Care Provider Perspectives, Kateryna Metersky Mar 2020

Patient Roles Within Interprofessional Collaborative Patient-Centred Care Teams: The Patient And Health Care Provider Perspectives, Kateryna Metersky

Electronic Thesis and Dissertation Repository

With current rapid expansions to medical knowledge and technology and rising chronicity of diseases, health care providers are increasingly called upon to work together within interprofessional teams to provide the most comprehensive care to their patients. Interprofessional teams have been depicted as enhancing patient health outcomes and increasing patient satisfaction with care, while decreasing health care spending and wait times for receiving care. However, there is little evidence on how to collaboratively include patients in these teams. The study’s purpose was to construct a framework on the conditions and processes required for patients to assume active participant roles in ...


Multimodality Imaging To Quantify The Pulmonary Vascular Tree In Copd, Andrea L. Barker Odhiambo Mar 2020

Multimodality Imaging To Quantify The Pulmonary Vascular Tree In Copd, Andrea L. Barker Odhiambo

Electronic Thesis and Dissertation Repository

Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating disease resulting in chronic cough, shortness of breath, activity limitation and decreased pulmonary function. Developments in imaging technology have provided sensitive and reliable modalities for evaluating regional lung function and disease progression, and there is a growing interest in the role of imaging the vasculature in COPD. The ability to predict whether a patient is at risk of accelerated decline is important to disease management strategies. We hypothesize that CT blood vessel volume measurements are significantly different in ex-smokers without COPD than in those with this disease and will be ...


Characterization And Enhancement Of Local Drug Delivery In Orthopaedic Infection, Tina Khazaee Mar 2020

Characterization And Enhancement Of Local Drug Delivery In Orthopaedic Infection, Tina Khazaee

Electronic Thesis and Dissertation Repository

The delivery of antibiotics is an important component of therapy for orthopedic device-related infections (ODRI). In this study, we have investigated new techniques to characterize and enhance antibiotic delivery for ODRI. Characterization of small-molecule diffusion is essential to the development of drug-delivery systems. We have developed a quantitative, non-invasive, longitudinal, micro-CT technique to quantify the diffusion of small-molecules in an intact phantom. We employed a radio-opaque molecule (i.e., Iohexol) as a surrogate for commonly used antibiotics (e.g., Vancomycin). We characterized diffusion from a finite-core carrier into an agar, tissue-equivalent phantom. The estimate of the diffusion coefficient was derived ...


Ganglioside Detection From Formalin Fixed Human Brain Tissue Utilizing Maldi Imaging Mass Spectrometry, Aaron Harris Mar 2020

Ganglioside Detection From Formalin Fixed Human Brain Tissue Utilizing Maldi Imaging Mass Spectrometry, Aaron Harris

Electronic Thesis and Dissertation Repository

Matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) is largely performed on fresh frozen tissue whereas clinical tissue samples stored long term are fixed in formalin, and the fixation process is thought to cause signal suppression for lipid molecules. Studies show that fresh frozen brain tissue sections washed with ammonium formate (AF) solution prior to matrix application in the MALDI-IMS procedure display an increase in signal intensity and sensitivity for lipid molecules while maintaining molecular spatial distribution. Work in this thesis compares MALDI data of ganglioside molecules from fresh frozen and post-fixed rat brain samples, and post-fixed human ...


Gestational Weight Gain - Its Importance To Pregnant Women And Their Children, Helena Piccinini-Vallis Mar 2020

Gestational Weight Gain - Its Importance To Pregnant Women And Their Children, Helena Piccinini-Vallis

Electronic Thesis and Dissertation Repository

INTRODUCTION

The amount of weight that women gain during pregnancy has an impact on their health and the health of their babies. However, most women experience gestational weight gain in excess of the recommended amounts.

OBJECTIVES

To gain a deeper understanding of women’s perspectives regarding gestational weight gain, to examine how they experience the advice that they receive pertaining to gestational weight gain, and to explore the association between gestational weight gain and their child’s weight status.

METHODS

Three studies of different research designs were conducted. The first was a systematic review of qualitative, quantitative, and mixed methods ...


Machine Learning Towards General Medical Image Segmentation, Clara Tam Mar 2020

Machine Learning Towards General Medical Image Segmentation, Clara Tam

Electronic Thesis and Dissertation Repository

The quality of patient care associated with diagnostic radiology is proportionate to a physician's workload. Segmentation is a fundamental limiting precursor to diagnostic and therapeutic procedures. Advances in machine learning aims to increase diagnostic efficiency to replace single applications with generalized algorithms. We approached segmentation as a multitask shape regression problem, simultaneously predicting coordinates on an object's contour while jointly capturing global shape information. Shape regression models inherent point correlations to recover ambiguous boundaries not supported by clear edges and region homogeneity. Its capabilities was investigated using multi-output support vector regression (MSVR) on head and neck (HaN) CT ...


Coaches Perceptions And Use Of An Online Sport Psychology Resource, Jade Farhat Mar 2020

Coaches Perceptions And Use Of An Online Sport Psychology Resource, Jade Farhat

Electronic Thesis and Dissertation Repository

Sport psychology has become widely applied in coaching practices to assist in athletic success. Despite the increased use, there is a lack of evidence-based sport psychology information available to coaches in the form of informal sources. The aim of this study was to explore coaches’ perceptions and use of a sport psychology website using mixed methods. Eight coaches participated in semi-structured interviews. A thematic analysis revealed five themes (current use, accessibility, attitudes, website use, website engagement). Google Analytics demonstrated coaches’ engagement with the website. Findings suggested that coaches perceive sport psychology to be relevant to their sport and the website ...


Social Connectedness And Self-Perceived Mental Health In Canadian Transitional Aged Youth, Romaisa Pervez Feb 2020

Social Connectedness And Self-Perceived Mental Health In Canadian Transitional Aged Youth, Romaisa Pervez

Electronic Thesis and Dissertation Repository

Introduction:Transitional aged youth (TAY; ages 15-24) is a vulnerable age group that face several life changes which contribute to many forms of distress in their lives.

Objective:To assess the impact social connectedness has on self-perceived mental health in Canadian TAY.

Methods:The dataset provided by the Canadian Community Health Survey 2016 cycle was used. Listwise deletion was used to handle missing data. The final sample size for the study was 5,378 youth between the ages of 15-24. Linear and ordinal logistic regressions were conducted for the statistical analysis of the dataset.

Results:With every point decrease in ...


A Coaching And/Or Education Intervention Targeting Physical Activity And Nutrition Behaviours In Parents With Overweight/Obesity And Their Children, Shazya Karmali Feb 2020

A Coaching And/Or Education Intervention Targeting Physical Activity And Nutrition Behaviours In Parents With Overweight/Obesity And Their Children, Shazya Karmali

Electronic Thesis and Dissertation Repository

The purpose of this dissertation is to provide a detailed overview of, findings from, and experiences participating in a 3-month randomized controlled trial (RCT) targeting obesity-related behaviours in parents with overweight/obesity (body mass index [BMI] ≥ 25 kg/m2) and their children (2.5-10 years old, any weight; N = 50 dyads). A concurrent mixed methods study comprised of an RCT and descriptive qualitative design was utilized. Parent-participants received Co-Active Life Coaching (CALC) and webinar-based health education (intervention) or education only (control). To address the dissertation’s purpose, Chapter II provides a detailed methodological account of the program, including rationale ...


Exploring Gender Equity Through Occupation: A Critical Decolonizing Ethnography In Tanzania, Stephanie Huff Feb 2020

Exploring Gender Equity Through Occupation: A Critical Decolonizing Ethnography In Tanzania, Stephanie Huff

Electronic Thesis and Dissertation Repository

Within the discipline of occupational science, scholars of increasingly diverse geographical spaces have highlighted the necessity of diversity and epistemological expansion to enact transformative scholarship. In response, this dissertation enacted a critical decolonizing ethnographic project with 5 women from Tanzania to explore their experiences of gender inequities.

This thesis is composed of four integrated manuscripts, as well as introduction and conclusion chapters. Manuscript two examines past perspectives and approaches to research which examined gender equity and inequity in Tanzania, illuminating gaps and recommendations for future gendered research in Tanzania. Manuscript three presents an argument for the uptake of Africana Womanism ...


Survey Of Canadian Orthodontists Regarding Orthodontic Miniscrew Usage, Leah A. Van Sant Feb 2020

Survey Of Canadian Orthodontists Regarding Orthodontic Miniscrew Usage, Leah A. Van Sant

Electronic Thesis and Dissertation Repository

Purpose: To obtain information on the clinical utilization of orthodontic miniscrews (OMSs) among orthodontists in Canada

Methods: Web-based software was used to fabricate a questionnaire in which respondents were asked questions regarding their usage of OMSs in their clinical practice. The survey consisted of between 11 and 39 questions, depending on the respondents’ answers. The survey was distributed via email to the 353 active Canadian members of the American Association of Orthodontists (AAO).

Results: A total of 82 Canadian orthodontists responded to the survey, for a response rate of 23.2%. Among them, 65.8% currently used miniscrews in their ...


The Health Experiences Of Long-Haul Truck Drivers And Their Relationship With Their Primary Care Provider, Jennifer K. Johnson Feb 2020

The Health Experiences Of Long-Haul Truck Drivers And Their Relationship With Their Primary Care Provider, Jennifer K. Johnson

Electronic Thesis and Dissertation Repository

Long-haul truck drivers in North America experience greater health risks than people employed in other occupations. The magnitude of their health risks is directly associated with crash risk which has implications for public road safety. The health experiences of long-haul truck drivers residing in Ontario, Canada and their relationship with their primary care provider were explored using a phenomenological approach. Themes of perseverance, isolation, dehumanization and living in a hidden, separate world emerged from the analysis. Focus groups were held where family physicians and nurse practitioners were asked for their responses to these findings and for their experiences caring for ...


Analysis Of Oxidatively Damaged Proteins By Mass Spectrometry, Vincent Saullo Feb 2020

Analysis Of Oxidatively Damaged Proteins By Mass Spectrometry, Vincent Saullo

Electronic Thesis and Dissertation Repository

As humans age, exposure to oxidative stress may induce protein degradation or aggregation; both resulting in loss of protein function. Protein oxidative damage remains a dominant pathology in many common ailments. To combat these pathologies, scientists must understand the nature of oxidative modifications and their effects on protein structure and dynamics. This work employs a range of mass spectrometry (MS) methods to characterize and analyze the effects of oxidative damage on the model protein myoglobin (Mb). Mb was oxidized using tert-butyl hydroperoxide, and the resulting modifications were characterized by top-down and bottom-up MS workflows. Hydrogen/deuterium exchange MS indicated elevated ...


Δ9-Tetrahydrocannabinol Exposure During Rat Pregnancy Leads To Symmetrical Fetal Growth Restriction And Labyrinth-Specific Vascular Defects In The Placenta., Bryony V Natale, Katarina N Gustin, Kendrick Lee, Alison C Holloway, Steven R Laviolette, David R C Natale, Daniel B Hardy Jan 2020

Δ9-Tetrahydrocannabinol Exposure During Rat Pregnancy Leads To Symmetrical Fetal Growth Restriction And Labyrinth-Specific Vascular Defects In The Placenta., Bryony V Natale, Katarina N Gustin, Kendrick Lee, Alison C Holloway, Steven R Laviolette, David R C Natale, Daniel B Hardy

Physiology and Pharmacology Publications

1 in 5 women report cannabis use during pregnancy, with nausea cited as their primary motivation. Studies show that (-)-△9-tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in cannabis, causes fetal growth restriction, though the mechanisms are not well understood. Given the critical role of the placenta to transfer oxygen and nutrients from mother, to the fetus, any compromise in the development of fetal-placental circulation significantly affects maternal-fetal exchange and thereby, fetal growth. The goal of this study was to examine, in rats, the impact of maternal Δ9-THC exposure on fetal development, neonatal outcomes, and placental development. Dams received a daily intraperitoneal ...


Sodium-Glucose Cotransporter-2 Inhibitor Use And The Risk Of Acute Kidney Injury In Older Adults In Routine Clinical Practice: A Population-Based Cohort Study, Carina Iskander Dec 2019

Sodium-Glucose Cotransporter-2 Inhibitor Use And The Risk Of Acute Kidney Injury In Older Adults In Routine Clinical Practice: A Population-Based Cohort Study, Carina Iskander

Electronic Thesis and Dissertation Repository

Regulatory agencies warn about acute kidney injury (AKI) risk following sodium-glucose cotransporter-2 (SGLT2) inhibitor use. This population-based retrospective cohort study in Ontario, Canada quantified the 90-day AKI risk in older adults who were newly dispensed either SGLT2 inhibitors or dipeptidyl peptidase-4 (DPP4) inhibitors in an outpatient setting between 2015 and 2017. Risk ratios (RR) were obtained using modified Poisson regression and risk differences using binomial regression. Relative to new use of a DPP4 inhibitor, initiation of an SGLT2 inhibitor was associated with a lower 90-day risk of a hospital encounter with AKI: 216 events in 19,611 patients (1.10 ...


Reliability And Validity Of Two Performance-Based Outcome Measures In Rehabilitation Following Total Knee Arthroplasty, Jennifer L. Van Bussel Dec 2019

Reliability And Validity Of Two Performance-Based Outcome Measures In Rehabilitation Following Total Knee Arthroplasty, Jennifer L. Van Bussel

Electronic Thesis and Dissertation Repository

Objectives: Performance-based outcome measures (PBOM) are suggested to evaluate change in function during rehabilitation after total knee arthroplasty (TKA). The purpose of this study was to evaluate the measurement properties of the 30-Second Chair Stand Test (30CST) and 10-Metre Walk Test (10MWT) in patients following TKA.

Methods: Eighty-three patients completed two PBOM on three occasions following surgery. Patients also completed the Western Ontario and McMaster Universities Osteoarthritis Index and Global Rating of Change (GRC).

Results: Intraclass correlation coefficients ranged from 0.82 to 0.96. The standard errors of measurement at 6 and 12 weeks postop, respectively, were: 30CST ±0 ...


Voice Analysis With Iphones: A Low Cost Experimental Solution, Benjamin Van Der Woerd Dec 2019

Voice Analysis With Iphones: A Low Cost Experimental Solution, Benjamin Van Der Woerd

Electronic Thesis and Dissertation Repository

Background:

Acoustic voice analysis requires a resource intensive setup, including a soundproof booth. This project evaluates smartphone microphone and recording environment impacts on voice sample collection for acoustic voice analysis. A proprietary analysis algorithm is presented for validation.

Methods:

Microphone and recording environment were evaluated using previously collected voice samples presented in four conditions to test two microphones and two recording environments. Prospective samples were used to test the proprietary algorithm, whereby samples were analyzed using this and Praat.

Results:

Microphone and recording environment had small, clinically unimportant impacts on most measurements. The proprietary algorithm reliably analyzed sustained vowels, with ...


Evaluating The Utility Of Protein Biomarker, S100a7, And Diagnostic Test, Straticyte, In Predicting The Progression Of Oral Dysplasia, Lachlan Mclean Dec 2019

Evaluating The Utility Of Protein Biomarker, S100a7, And Diagnostic Test, Straticyte, In Predicting The Progression Of Oral Dysplasia, Lachlan Mclean

Electronic Thesis and Dissertation Repository

Five-year survival of oral cancer has remained relatively unchanged despite advancements in treatment, mostly because diagnosis is often made at an advanced stage of disease. The progression of dysplasia to oral cancer often follows a stepwise progression. Histopathology is considered the ‘gold standard’ for diagnosing dysplasia and lesions at a high risk of progression to oral cancer, but lends itself to subjectivity. The protein biomarker, S100A7, in oral dysplasia and squamous cell carcinoma has shown some predictive value for the transformation of dysplasia to cancer. Straticyte, a diagnostic test utilizing S100A7 to predict the probability of progression of oral dysplasia ...


Junctophilin-2 Protects Cardiomyocytes Against Palmitate-Induced Injury, Xiaoyun Ji Dec 2019

Junctophilin-2 Protects Cardiomyocytes Against Palmitate-Induced Injury, Xiaoyun Ji

Electronic Thesis and Dissertation Repository

Cardiac lipotoxicity may induce cardiomyocyte apoptosis, eventually leading to myocardial dysfunction and heart failure. This study investigated whether and how junctophilin-2 (JPH2) plays a role in palmitate-induced apoptosis in cardiomyocytes. Here, we found palmitate incubation reduced JPH2 protein levels, increased cytosolic Ca2+ and induced apoptosis in cardiomyocytes. JPH2 over-expression prevented the increased cytosolic Ca2+ and apoptosis in palmitate-stimulated cardiomyocytes. JPH2 over-expression also attenuated palmitate-induced CCAAT-enhancer-binding protein homologous protein (CHOP) expression and CHOP deletion alleviated palmitate-induced apoptosis. Furthermore, blocking Ca2+ release from ryanodine receptor-2 (RyR2) prevented palmitate-stimulated CHOP induction and apoptosis. Additionally, JPH2 silencing elevated cytosolic Ca2 ...


An Exploration Of How Persons Requiring Hemodialysis Treatment Explain The Ways In Which Access To Transportation For Such Treatment Influences Their Overall Health., Navpreet Kamboj Nov 2019

An Exploration Of How Persons Requiring Hemodialysis Treatment Explain The Ways In Which Access To Transportation For Such Treatment Influences Their Overall Health., Navpreet Kamboj

Electronic Thesis and Dissertation Repository

The number of Canadians being treated for kidney failure has more than tripled in the last 20 years, making hemodialysis (HD) a more common and expensive treatment option. Individuals having in-center HD require access to transportation to and from an HD center on average three days a week for a total of six trips. Therefore, access to transportation is a vital component for sustaining the health and well-being of this population. The purpose of this interpretive descriptive qualitative study was to explore how persons requiring in-center HD treatment explain the ways in which access to transportation for such treatment influences ...


Saponin Penetration And Interactions With Membranes, Sarai Guerrero Nov 2019

Saponin Penetration And Interactions With Membranes, Sarai Guerrero

Electronic Thesis and Dissertation Repository

The saponin QS21 has been used and studied for years as an adjuvant agent to improve vaccines for both humans and animals. However, how the saponin interacts with the membrane and itself remains poorly understood. We studied the QS21-A majority isomer using all-atom classical molecular dynamics simulations in model bilayers composed of cholesterol and either DOPC or DPPC. As this is one of the few computational studies on QS21-A, we had very few resources to compare our results to. Nevertheless, we were able to gain insight into possible configurations that QS21-A takes after penetration, the effect of the bilayer on ...


The Difference In A1c Of Children And Adolescents With Type 1 Diabetes Mellitus Using Carbohydrate Counting Compared To Those Using A Structured Meal Plan, Alia El Kubbe Nov 2019

The Difference In A1c Of Children And Adolescents With Type 1 Diabetes Mellitus Using Carbohydrate Counting Compared To Those Using A Structured Meal Plan, Alia El Kubbe

Electronic Thesis and Dissertation Repository

Carbohydrate counting (CHO) is a nutrition education tool used by patients with type 1 diabetes mellitus (T1DM). The primary objective was to assess glycated hemoglobin (A1C) in participants with T1DM using CHO counting vs. those using a structured meal plan (SMP). The secondary objectives were to determine if BMI-for-age, parental income, parental involvement, and mothers’ educational level were associated with their children’s glycemic control. A cross sectional study was conducted, where participants aged 4-18 years, or their parents completed a survey. Total sample size was 88 participants (77 in the CHO counting group and 11 in the SMP group ...