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2006

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Full-Text Articles in Medicine and Health Sciences

Developing A Web-Based Training Directory For Children’S Mental Health Professionals, Ardis Hanson, William Kearns, Tanya Thomas Jul 2015

Developing A Web-Based Training Directory For Children’S Mental Health Professionals, Ardis Hanson, William Kearns, Tanya Thomas

William D. Kearns, PhD

No abstract provided.


Aflatoxicosis In Dogs And Dealing With Suspected Contaminated Commercial Foods, Katherine Stenske, J Smith, Shelley Newman, L Newman, Claudia Kirk Jan 2015

Aflatoxicosis In Dogs And Dealing With Suspected Contaminated Commercial Foods, Katherine Stenske, J Smith, Shelley Newman, L Newman, Claudia Kirk

Shelley Newman

No abstract provided.


Estimation Of Uninsurance Rate: Comparison Of Four Estimation Methods, Jackie Zhang, Renee Hotchkiss, Thomas Wan Jul 2014

Estimation Of Uninsurance Rate: Comparison Of Four Estimation Methods, Jackie Zhang, Renee Hotchkiss, Thomas Wan

Thomas T.H. Wan

Objective: Although high percentage of the uninsured is an important public policy issue, the discrepancies in both state and national estimates of the numbers of uninsured are reported. This study compares four advanced estimation methods for uninsurance, by using Florida Health Insurance Survey data as an example. Design: The four predictive models include decision tree, neural network, general logistic regression, and two-stage logistic regression. Risk factors to uninsurance are identified. Population: The study sample comes from the Florida Health Insurance Study data collected for the Florida Agency of Health Care Administration in 1999, representing the first large-scale study designed exclusively ...


Ocular Dermoids In Cattle: A Case Report, Jose Castro, Diane Hendrix, Sarel Van Amstel Dec 2013

Ocular Dermoids In Cattle: A Case Report, Jose Castro, Diane Hendrix, Sarel Van Amstel

Diane Hendrix

No abstract provided.


Calpain Inhibitor Mdl28170 Modulates Abeta Formation By Inhibiting The Formation Of Intermediate Abeta46 And Protecting Abeta From Degradation, Y Dong, J Tan, Mei-Zhen Cui, G Zhao, G Mao, N Singh, Xuemin Xu Jun 2013

Calpain Inhibitor Mdl28170 Modulates Abeta Formation By Inhibiting The Formation Of Intermediate Abeta46 And Protecting Abeta From Degradation, Y Dong, J Tan, Mei-Zhen Cui, G Zhao, G Mao, N Singh, Xuemin Xu

Mei-Zhen Cui

The observations that three major cleavages within the transmembrane domain of APP, namely, the gamma-cleavage, -cleavage, and the newly identified zeta-cleavage, are involved in the generation of secreted Abeta40 and Abeta42 prompted us to determine how the calpain inhibitor III MDL 28170 influences these three cleavages and Abeta formation. With the use of a cell culture system, our data demonstrate that 1) at either high concentrations, or at a low range of concentrations, at early time points, MDL 28170 inhibits the formation of secreted Abeta40 and Abeta42. However, this effect is due to inhibition of the intermediate Abeta46 generation by ...


Whole Body Edema And Mineralized Fat Necrosis In An Aquatic Caecilian, Typhlonectes Sp., J Sykes, Danielle Reel, George Henry, Michael Fry, S Smith Jun 2013

Whole Body Edema And Mineralized Fat Necrosis In An Aquatic Caecilian, Typhlonectes Sp., J Sykes, Danielle Reel, George Henry, Michael Fry, S Smith

George A Henry, DVM

A 13 year old male aquatic caecilian, Typhlonectes sp., presented with whole body swelling and a radiodense coelomic mass was identified radiographically. The mass was found to be free-floating during surgical exploration, was removed, and histologically determined to be mineralized fat necrosis. The animal did not recover from anesthesia and necropsy findings included excessive free coelomic fluid, a severely dilated venous structure, and a dermatopathy of unknown etiology. The animal's death was attributed to complications of anesthesia and circulatory compromise. Though no specific etiology was found, the whole body oedema was attributed to disruption of normal osmoregulation due to ...


Environmental Equity Is Child's Play: Mapping Public Provision Of Recreation Opportunities In Urban Neighbourhoods, Jason Gilliland, Martin Holmes, Jennifer Irwin, Patricia Tucker May 2013

Environmental Equity Is Child's Play: Mapping Public Provision Of Recreation Opportunities In Urban Neighbourhoods, Jason Gilliland, Martin Holmes, Jennifer Irwin, Patricia Tucker

Trish Tucker

This paper examines the spatial distribution of recreational opportunities for children and youth in a mid-sized Canadian city (London, Ontario), in relation to the socioeconomic status of neighbourhoods and estimated local need for publicly provided recreation spaces. Public recreation facilities (N = 537) throughout the city were identified, mapped and analysed in a geographic information system. To explore potential socio-environmental inequities, neighbourhoods (N = 22) were characterized by socioeconomic and environmental variables, an index of neighbourhood social distress, a neighbourhood play space needs index, and measures of the prevalence and density of recreational opportunities. The results of the spatial analysis indicate there ...


Feasibility Of A Campus-Based "Buddy System" To Promote Physical Activity: Canadian Students' Perspectives, Patricia Tucker, Jennifer Irwin May 2013

Feasibility Of A Campus-Based "Buddy System" To Promote Physical Activity: Canadian Students' Perspectives, Patricia Tucker, Jennifer Irwin

Trish Tucker

Objective: To explore the characteristics of a university-wide buddy system that students would be receptive to using. Methods: This study targeted a heterogeneous sample of undergraduate university students age 18 to 25 y. An experienced moderator, using a semi-structured interview guide, conducted 13 focus groups (n = 65). Focus group discussions were audio recorded and transcribed verbatim. Inductive content analysis was conducted independently by two researchers. Measures were incorporated throughout to ensure data trustworthiness. Results: The value of this campus-based physical activity intervention was emphasized by the vast majority of participants. Five main themes exemplified students' preferences: sign-up methods; matching criteria ...


Carcinoma Ex Pleomorphic Adenoma With Sebaceous Differentiation In The Mandibular Salivary Gland Of A Dog, Olga Smrkovski, Amy Leblanc, S Smith, Casey Leblanc, William Adams, Karen Tobias Feb 2013

Carcinoma Ex Pleomorphic Adenoma With Sebaceous Differentiation In The Mandibular Salivary Gland Of A Dog, Olga Smrkovski, Amy Leblanc, S Smith, Casey Leblanc, William Adams, Karen Tobias

William H Adams, DVM, DACVR

A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog. The animal presented with a large nonpainful swelling in the left submandibular region. A computed tomography scan detected an irregularly enhancing soft tissue mass that was closely associated with the left external ear canal and extended to the left wing of the atlas. On surgical exploration, the mass was intimately associated with the left mandibular salivary gland. Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology. The tumor was comprised of basaloid and low ...


Comparative Antinociception Of Morphine, Butorphanol, And Buprenorphine Versus Saline In The Green Iguana (Iguana Iguana) Using Electrostimulation, Cheryl Greenacre, G Takle, Juergen Schumacher, Ek Klaphake, Ralph Harvey Jul 2012

Comparative Antinociception Of Morphine, Butorphanol, And Buprenorphine Versus Saline In The Green Iguana (Iguana Iguana) Using Electrostimulation, Cheryl Greenacre, G Takle, Juergen Schumacher, Ek Klaphake, Ralph Harvey

Juergen P. Schumacher

No abstract provided.


Cardiovascular Involvement In 8 Dogs With Blastomyces Dermatitidis Infection, C Schmeidt, H Kellum, Alfred Legendre, Rebecca Gompf, J Bright, C Houle, M Schutten, R Stepien Jul 2012

Cardiovascular Involvement In 8 Dogs With Blastomyces Dermatitidis Infection, C Schmeidt, H Kellum, Alfred Legendre, Rebecca Gompf, J Bright, C Houle, M Schutten, R Stepien

Alfred M Legendre DVM, MS, DACVIM

BACKGROUND: Blastomycosis is a common systemic fungal infection in dogs. HYPOTHESIS: Dogs with cardiovascular involvement may have abnormalities in electrical conduction and valvular function, and may have a worse prognosis. ANIMALS: Eight client-owned animals. METHODS: Dogs with cardiovascular lesions caused by blastomycosis were identified from retrospective evaluation of medical records. RESULTS: Five dogs had de novo infections and 3 had recurrences of previously treated infections. Harsh labored breathing, lethargy, and anorexia were the most common historic complaints. Three dogs had syncope. Physical examination and clinicopathologic data were typical of blastomycosis and included dyspnea, increased lung sounds, and lethargy. In addition ...


Evaluation Of The Combined Dexamethasone Suppression/ Thyrotropin-Releasing Hormone Stimulation Test For Detection Of Pars Intermedia Pituitary Adenomas In Horses, Nicholas Frank, Frank Andrews, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Robert Donnell Apr 2012

Evaluation Of The Combined Dexamethasone Suppression/ Thyrotropin-Releasing Hormone Stimulation Test For Detection Of Pars Intermedia Pituitary Adenomas In Horses, Nicholas Frank, Frank Andrews, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Robert Donnell

Barton W Rohrbach Dr.

BACKGROUND: A combined dexamethasone (DEX) suppression/thyrotropin-releasing hormone (TRH) test (DEX/TRH test) has been developed to evaluate horses for presence of a pars intermedia pituitary adenoma (PIPA), but to the authors' knowledge, the accuracy of this test has not been previously determined. HYPOTHESIS: The sensitivity and specificity of the DEX/TRH test can be determined by comparing test results with histopathologic examination findings. ANIMALS: Age of 42 horses of various breeds ranged from 2 to 33 years. METHODS: Plasma cortisol concentration was measured before and 24 hours after IV administration of 40 microg of DEX/kg of body weight ...


Causes Of Acute Renal Failure, Jennifer Stokes, Joe Bartges Mar 2012

Causes Of Acute Renal Failure, Jennifer Stokes, Joe Bartges

Jennifer E. Stokes DVM, DACVIM, College of Veterinary Medicine

Acute renal failure (ARF) is devastating in dogs and cats, with a mortality rate of over 50%. Causes include prerenal, intrinsic renal, and postrenal conditions. Infectious disease (leptospirosis, bacterial pyelonephritis, borreliosis) and toxicity (medications, plants, antifreeze) are the most common causes of ARF in dogs and cats. Ureteral obstruction in cats is being recognized more frequently as a postrenal cause of ARF.


A Comparison Of Four Methods Of Analgesia In Cats Following Ovariohysterctomy, Karen Tobias, Ralph Harvey, Jm Byarlay Feb 2012

A Comparison Of Four Methods Of Analgesia In Cats Following Ovariohysterctomy, Karen Tobias, Ralph Harvey, Jm Byarlay

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Objective:  To evaluate the effectiveness of preoperative administration of oral carprofen, subcutaneous ketoprofen, and local nerve block with bupivacaine in preventing postoperative pain-associated behavior in cats after ovariohysterectomy. Animals:  Fifty-two female intact cats. Materials and methods:  Cats received butorphanol (0.44 mg kg−1 IM), carprofen (2.2 mg kg−1 PO), ketoprofen (2.2 mg kg−1 SQ), or bupivacaine infiltration block (1.1 mg kg−1 SQ) before surgery. Cortisol and drug concentrations and visual analog scale (VAS) and interactive visual analog scale (IVAS) pain-associated behavior scores were measured 2 hours before and 0, 1, 2, 4, 8 ...


Comparative Anesthetic And Cardiopulmonary Effects Of Pre- Versus Postoperative Butorphanol Administration In Hispaniolan Amazon Parrots (Amazona Ventralis) Anesthetized With Sevoflurane, Eric Klaphake, Juergen Schumacher, Cheryl Greenacre, Michael Jones, Nancy Zagaya Jan 2012

Comparative Anesthetic And Cardiopulmonary Effects Of Pre- Versus Postoperative Butorphanol Administration In Hispaniolan Amazon Parrots (Amazona Ventralis) Anesthetized With Sevoflurane, Eric Klaphake, Juergen Schumacher, Cheryl Greenacre, Michael Jones, Nancy Zagaya

Cheryl B Greenacre DVM

Anesthetic and cardiopulmonary effects of butorphanol administered pre-versus postoperatively were determined and compared in 11 adult Hispaniolan Amazon parrots (Amazona ventralis) anesthetized with sevoflurane and subjected to coelomic endoscopy for gonadal evaluation. Birds were randomly assigned to receive butorphanol tartrate (2 mg/kg IM) either 20 minutes before induction of anesthesia with sevoflurane (B-S group) or immediately after sevoflurane anesthesia (S group). No differences in induction or recovery times were seen between groups. Heart rates of birds in the B-S group were significantly higher at 30 minutes compared with baseline and with heart rates of birds in the S group ...


Evaluation Of The Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test For Detection Of Pars Intermedia Pituitary Adenomas In Horses, Nicholas Frank, Frank Andrews, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Robert Donnell Jan 2012

Evaluation Of The Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test For Detection Of Pars Intermedia Pituitary Adenomas In Horses, Nicholas Frank, Frank Andrews, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Robert Donnell

Hugo Eiler DVM, MS, PhD

Background: A combined dexamethasone (DEX) suppression/thyrotropin-releasing hormone (TRH) test (DEX/TRH test) has been developed to evaluate horses for presence of a pars intermedia pituitary adenoma (PIPA), but to the authors' knowledge, the accuracy of this test has not been previously determined. Hypothesis: The sensitivity and specificity of the DEX/TRH test can be determined by comparing test results with histopathologic examination findings. Animals: Age of 42 horses of various breeds ranged from 2 to 33 years. Methods: Plasma cortisol concentration was measured before and 24 hours after IV administration of 40 g of DEX/kg of body weight ...


Surveillance Of The Colorectal Cancer Disparities Among Demographic Subgroups: A Spatial Analysis, Chiehwen Hsu, Francisco Soto Mas Jan 2012

Surveillance Of The Colorectal Cancer Disparities Among Demographic Subgroups: A Spatial Analysis, Chiehwen Hsu, Francisco Soto Mas

Francisco Soto Mas

Objective: The literature suggests that colorectal cancer mortality in Texas is distributed inhomogeneously among specific demographic subgroups and in certain geographic regions over an extended period. To understand the extent of the demographic and geographic disparities, the present study examined colorectal cancer mortality in 15 demographic groups in Texas counties between 1990 and 2001. Methods: The Spatial Scan Statistic was used to assess the standardized mortality ratio, duration and age-adjusted rates of excess mortality, and their respective p-values for testing the null hypothesis of homogeneity of geographic and temporal distribution. Results: The study confirmed the excess mortality in some Texas ...


Carcinoma Ex Pleomorphic Adenoma With Sebaceous Differentiation In The Mandibular Salivary Gland Of A Dog, Olga Smrkovski, Amy Leblanc, S Smith, Casey Leblanc, William Adams, Karen Tobias Jan 2012

Carcinoma Ex Pleomorphic Adenoma With Sebaceous Differentiation In The Mandibular Salivary Gland Of A Dog, Olga Smrkovski, Amy Leblanc, S Smith, Casey Leblanc, William Adams, Karen Tobias

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog. The animal presented with a large nonpainful swelling in the left submandibular region. A computed tomography scan detected an irregularly enhancing soft tissue mass that was closely associated with the left external ear canal and extended to the left wing of the atlas. On surgical exploration, the mass was intimately associated with the left mandibular salivary gland. Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology. The tumor was comprised of basaloid and low ...


Analysis Of Genetic Mutations In The 7a7b Open Reading Frame Of Coronavirus Of Cheetahs (Acinonyx Jubatus), Melissa Kennedy, E Moore, R Wilkes, S Citino, Stephen Kania Jan 2012

Analysis Of Genetic Mutations In The 7a7b Open Reading Frame Of Coronavirus Of Cheetahs (Acinonyx Jubatus), Melissa Kennedy, E Moore, R Wilkes, S Citino, Stephen Kania

Melissa A. Kennedy

OBJECTIVE: To analyze the 7a7b genes of the feline coronavirus (FCoV) of cheetahs, which are believed to play a role in virulence of this virus. SAMPLE POPULATION: Biologic samples collected during a 4-year period from 5 cheetahs at the same institution and at 1 time point from 4 cheetahs at different institutions. PROCEDURES: Samples were first screened for FCoV via a reverse transcription-PCR procedure involving primers that encompassed the 3'-untranslated region. Samples that yielded positive assay results were analyzed by use of primers that targeted the 7a7b open reading frames. The nucleotide sequences of the 7a7b amplification products were ...


Diet-Associated Hepatic-Failure And Immune-Mediated Hemolytic Anemia In A Weimaraner, A Smith, Katherine Stenske, Joe Bartges, Claudia Kirk Dec 2011

Diet-Associated Hepatic-Failure And Immune-Mediated Hemolytic Anemia In A Weimaraner, A Smith, Katherine Stenske, Joe Bartges, Claudia Kirk

Claudia A Kirk

Objective: To describe the medical and nutritional management of a 4-year-old Weimaraner with acute hepatic failure and immune-mediated haemolytic anemia (IMHA) associated with consuming a commercial dog food. Case summary: A 4-year-old male castrated Weimaraner developed signs of IMHA, hepatic failure, disseminated intravascular coagulopathy, and malnutrition after consuming a commercial dog food. During the course of hospitalization, medical management included immunosuppressive therapy and supportive care. Nutritional support consisted of both enteral and parenteral nutrition. The dog was discharged after 19 days of hospitalization and fully recovered at 6 months time. An investigation by the Food and Drug Administration was not ...


Comparative Anesthetic And Cardiopulmonary Effects Of Pre- Versus Postoperative Butorphanol Administration In Hispaniolan Amazon Parrots (Amazona Ventralis) Anesthetized With Sevoflurane, Eric Klaphake, Juergen Schumacher, Cheryl Greenacre, Michael Jones, Nancy Zagaya Nov 2011

Comparative Anesthetic And Cardiopulmonary Effects Of Pre- Versus Postoperative Butorphanol Administration In Hispaniolan Amazon Parrots (Amazona Ventralis) Anesthetized With Sevoflurane, Eric Klaphake, Juergen Schumacher, Cheryl Greenacre, Michael Jones, Nancy Zagaya

Juergen P. Schumacher

Anesthetic and cardiopulmonary effects of butorphanol administered pre-versus postoperatively were determined and compared in 11 adult Hispaniolan Amazon parrots (Amazona ventralis) anesthetized with sevoflurane and subjected to coelomic endoscopy for gonadal evaluation. Birds were randomly assigned to receive butorphanol tartrate (2 mg/kg IM) either 20 minutes before induction of anesthesia with sevoflurane (B-S group) or immediately after sevoflurane anesthesia (S group). No differences in induction or recovery times were seen between groups. Heart rates of birds in the B-S group were significantly higher at 30 minutes compared with baseline and with heart rates of birds in the S group ...


Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams Sep 2011

Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams

Russ Chess-Williams

Objective: The role of tachykinins such as neurokinin A in regulating bladder function is unclear, but NK2 receptors seem to mediate contraction in the human bladder and it has been suggested that these peptides may have a role in the pathophysiology of bladder dysfunction. The present study investigates neurokinin receptor-mediated contractility of detrusor muscle in the idiopathic overactive and neurogenic overactive bladder and investigates the neurokinin receptor subtypes involved.

Methods: Human bladder was obtained from patients undergoing cystectomy (normal) or clam cystoplasty (idiopathic overactive) and from patients with spinal injuries (neurogenic overactive). Strips of isolated detrusor muscle were mounted in ...


Maternally And Naturally Acquired Antibodies To Mannheimia Haemolytica And Pasteurella Multocida In Beef Calves, Maria Prado, Tulio Prado, M. Payton, Aw Confer Aug 2011

Maternally And Naturally Acquired Antibodies To Mannheimia Haemolytica And Pasteurella Multocida In Beef Calves, Maria Prado, Tulio Prado, M. Payton, Aw Confer

Tulio M Prado

The dynamics and duration of maternally derived antibodies as well as the onset of acquired immunity against Mannheimia haemolytica and Pasteurella multocida in range-pastured beef calves were investigated. Two groups of unvaccinated cattle were used in this study. Serum antibody responses were measured by enzyme-linked immunoassay for antibodies of the IgG1, IgG2 and IgM isotypes binding M. haemolytica whole cells (WC) or leukotoxin (LKT) and P. multocida outer membrane proteins (OMPs). Comparisons of mean antibody responses to M. haemolytica LKT and WC and P. multocida OMPs were made within each group. Maternally derived antibodies against M. haemolytica and P. multocida ...


Evaluation Of An Implanted Osmotic Pump For Delivery Of Amikasin To Corn Snakes (Elaphe Guttata Guttata)., John Sykes, Edward Ramsay, Juergen Schumacher, Gregory Daniel, Sherry Cox, Mark Papich Aug 2011

Evaluation Of An Implanted Osmotic Pump For Delivery Of Amikasin To Corn Snakes (Elaphe Guttata Guttata)., John Sykes, Edward Ramsay, Juergen Schumacher, Gregory Daniel, Sherry Cox, Mark Papich

Juergen P. Schumacher

The risk of accidental envenomation to the handler of venomous snakes during drug administration limits the ability to treat these animals. One commercially available osmotic pump is a miniature self-contained cylindrical implant that operates on the basis of an osmotic pressure difference between the extracellular fluid and the osmotic agent in the pump. Osmotic pumps loaded with amikacin were surgically placed into the coelomic cavity of five adult corn snakes (Elaphe guttata guttata) (group A). Four snakes (group B) received an intramuscular injection of amikacin at 5 mg/kg followed by 2.5 mg/kg q 72 hr for a ...


Effects Of Ketamine On Carfentanil And Xylazine Immobilization Of White-Tailed Deer (Odocoileus Virginianus), Timothy Storms, Juergen Schumacher, David Osborn, Karl Miller, Edward Ramsay Aug 2011

Effects Of Ketamine On Carfentanil And Xylazine Immobilization Of White-Tailed Deer (Odocoileus Virginianus), Timothy Storms, Juergen Schumacher, David Osborn, Karl Miller, Edward Ramsay

Juergen P. Schumacher

Using a crossover design, the effects of the addition of ketamine to a previously determined optimal hand-injected immobilization dosage of carfentanil/xylazine were evaluated in 11 adult white-tailed deer (Odocoileus virginianus). Two i.m. ketamine dosages were evaluated: 0.15 mg/kg (low ketamine) and 0.30 mg/kg (high ketamine). Each deer was immobilized twice 2 wk apart. Inductions were video recorded and reviewed by observers, who had been blinded to drugs and dosages, who rated qualitative aspects. There were significant (P < 0.05) dosage-dependent decreases in heart rate, SaO2, and arterial pH, and a significant dosage-dependent increase in PaCO2. Induction times with both dosages were more rapid (mean 2.3 +/- 0.9 min for low ketamine and 2.3 +/- 0.6 min for high ketamine) than those reported for the same carfentanil/xylazine dosage used without ketamine. Mean quality ratings, though improved compared to those reported for carfentanil/xylazine alone, were considered "undesirable" for both dosages. Hyperthermia (temperature > 41 degrees C) was noted in 13 of 22 immobilizations. Arterial pH and PaO2 increased significantly from ...


Preliminary Evaluation Of 99mTc-Dtpa, 99mTc-Dmsa, 99m, And Tc-Mag3 For Renal Scintigraphy In Corn Snakes (Elaphe Guttata Guttata), Jm Sykes, Juergen Schumacher, J Avenell, Edward Ramsay, Gregory Daniel Aug 2011

Preliminary Evaluation Of 99mTc-Dtpa, 99mTc-Dmsa, 99m, And Tc-Mag3 For Renal Scintigraphy In Corn Snakes (Elaphe Guttata Guttata), Jm Sykes, Juergen Schumacher, J Avenell, Edward Ramsay, Gregory Daniel

Juergen P. Schumacher

The efficacy of three radiopharmaceuticals, 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA), 99mTc-dimercaptosuccinic acid (99mTc-DMSA), and 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), for renal imaging was examined in 16 corn snakes (Elaphe guttata guttata). All snakes received the radiopharmaceutical via an intracardiac injection. The kidneys could not be visualized in the three snakes that received 99mTc-DTPA or in the three snakes that received 99mTc-DMSA, but were well delineated in all 10 snakes receiving 99mTc-MAG3. These snakes were anesthetized and a dynamic frame mode acquisition was obtained for 30 min immediately following injection. A 60 s single static frame mode image was then obtained with the snake in a ...


A Type Iv P-Type Atpase Affects Insulin-Mediated Glucose Uptake In Adipose Tissue And Skeletal Muscle In Mice, Madhu Dhar, Joshua Yuan, Sarah Elliott, Carla Sommardahl Aug 2011

A Type Iv P-Type Atpase Affects Insulin-Mediated Glucose Uptake In Adipose Tissue And Skeletal Muscle In Mice, Madhu Dhar, Joshua Yuan, Sarah Elliott, Carla Sommardahl

Carla S. Sommardahl

Mice carrying two pink-eyed dilution (p) locus heterozygous deletions represent a novel polygenic mouse model of type 2 diabetes associated with obesity. Atp10c, a putative aminophospholipid transporter on mouse chromosome 7, is a candidate for the phenotype. The phenotype is diet-induced. As a next logical step in the validation and characterization of the model, experiments to analyze metabolic abnormalities associated with these mice were carried out. Results demonstrate that mutants (inheriting the p deletion maternally) heterozygous for Atp10c are hyperinsulinemic, insulin-resistant and have an altered insulin-stimulated response in peripheral tissues. Adipose tissue and the skeletal muscle are the targets, and ...


Evaluation Of The Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test For Detection Of Pars Intermedia Pituitary Adenomas In Horses, Nicholas Frank, Frank Andrews, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Robert Donnell Aug 2011

Evaluation Of The Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test For Detection Of Pars Intermedia Pituitary Adenomas In Horses, Nicholas Frank, Frank Andrews, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Robert Donnell

Carla S. Sommardahl

Background: A combined dexamethasone (DEX) suppression/thyrotropin-releasing hormone (TRH) test (DEX/TRH test) has been developed to evaluate horses for presence of a pars intermedia pituitary adenoma (PIPA), but to the authors' knowledge, the accuracy of this test has not been previously determined. Hypothesis: The sensitivity and specificity of the DEX/TRH test can be determined by comparing test results with histopathologic examination findings. Animals: Age of 42 horses of various breeds ranged from 2 to 33 years. Methods: Plasma cortisol concentration was measured before and 24 hours after IV administration of 40 g of DEX/kg of body weight ...


Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller Aug 2011

Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller

Howard K. Plummer III

Human lung cancer cell lines are widely used to test anticancer drugs. These in-vitro tests, however, preclude the detection of responses to paracrine factors from surrounding stroma. We have cocultured pulmonary fibroblasts CCD-19Lu, from a healthy donor, or HLF-A, from a patient with epidermoid carcinoma of the lung, with two human pulmonary adenocarcinoma cell lines to test the hypothesis that the fibroblasts stimulate the growth of the tumor cells. Both fibroblast cell lines significantly increased the proliferation of the pulmonary adenocarcinoma cell lines in 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assays, with HLF-A fibroblasts yielding the most pronounced responses ...


Protein Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girk) In Breast Cancer Cells, Madhu Dhar, Howard Plummer Aug 2011

Protein Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girk) In Breast Cancer Cells, Madhu Dhar, Howard Plummer

Howard K. Plummer III

Background Previous data from our laboratory has indicated that a functional link exists between the G-protein-coupled inwardly rectifying potassium (GIRK) channel and the beta-adrenergic receptor pathway in breast cancer cell lines, and these pathways were involved in growth regulation of these cells. Alcohol is an established risk factor for breast cancer and has been found to open GIRK. In order to further investigate GIRK channels in breast cancer and possible alteration by ethanol, we identified GIRK channel protein expression in breast cancer cells. Results Cell pellets were collected and membrane protein was isolated to determine GIRK protein expression. GIRK protein ...