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2003

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Articles 1 - 30 of 1731

Full-Text Articles in Medicine and Health Sciences

Inhibition Of Collagenase Breakdown Of Equine Corneas By Tetanus Antitoxin, Equine Serum And Acetylcysteine, Kellie Fecteau, J Haffner, Hugo Eiler Jun 2014

Inhibition Of Collagenase Breakdown Of Equine Corneas By Tetanus Antitoxin, Equine Serum And Acetylcysteine, Kellie Fecteau, J Haffner, Hugo Eiler

Kellie Fecteau

OBJECTIVE: To determine whether tetanus antitoxin, equine serum, and acetylcysteine, which are currently used in the treatment of equine corneal ulcer, inhibit the digestion of equine corneal collagen when exposed to collagenase in vitro. ANIMALS STUDIED: Corneas from 40 adult horses. PROCEDURES: Sections of equine corneas were incubated with saline, a solution of bacterial collagenase in saline, bacterial collagenase in saline plus equine tetanus antitoxin, bacterial collagenase in saline plus equine serum, or bacterial collagenase in saline plus acetylcysteine. Each one of the collagenase inhibitors was tested at different concentrations. The degree of corneal collagen digestion was determined by concentrations ...


Thrombin Rapidly Induces Protein Kinase D Phosphorylation, And Protein Kinase C Delta Mediates The Activation, M Tan, Xuemin Xu, M Ohba, W Ogawa, Mei-Zhen Cui Jun 2013

Thrombin Rapidly Induces Protein Kinase D Phosphorylation, And Protein Kinase C Delta Mediates The Activation, M Tan, Xuemin Xu, M Ohba, W Ogawa, Mei-Zhen Cui

Mei-Zhen Cui

Thrombin plays a critical role in hemostasis, thrombosis, and inflammation. However, the responsible intracellular signaling pathways triggered by thrombin are still not well defined. We report here that thrombin rapidly and transiently induces activation of protein kinase D (PKD) in aortic smooth muscle cells. Our data demonstrate that protein kinase C (PKC) inhibitors completely block thrombin-induced PKD activation, suggesting that thrombin induces PKD activation via a PKC-dependent pathway. Furthermore, our results show that thrombin rapidly induces PKC delta phosphorylation and that the PKC delta-specific inhibitor rottlerin blocks thrombin-induced PKD activation, suggesting that PKC delta mediates the thrombin-induced PKD activation. Using ...


Lysophosphatidic Acid, Tissue Factor And Atherosclerosis (Invited Commentary), Mei-Zhen Cui, Xuemin Xu Jun 2013

Lysophosphatidic Acid, Tissue Factor And Atherosclerosis (Invited Commentary), Mei-Zhen Cui, Xuemin Xu

Mei-Zhen Cui

http://www.athero.org


Lysophosphatidic Acid Induction Of Tissue Factor Expression In Aortic Smooth Muscle Cells, Mei-Zhen Cui, G Zhao, Al Winokur, E Laag, Jr Bydash, Ms Penn, Gm Chisolm, Xuemin Xu Jun 2013

Lysophosphatidic Acid Induction Of Tissue Factor Expression In Aortic Smooth Muscle Cells, Mei-Zhen Cui, G Zhao, Al Winokur, E Laag, Jr Bydash, Ms Penn, Gm Chisolm, Xuemin Xu

Mei-Zhen Cui

OBJECTIVE: Tissue factor (TF), the initiator of the coagulation cascade, is expressed by cells in atherosclerotic lesions. Lysophosphatidic acid (LPA) is a component of oxidized lipoproteins and an agent released by activated platelets. The present study investigated whether and how TF expression is regulated by LPA. METHODS AND RESULTS: Northern blotting, Western blotting, and TF activity assays demonstrated that LPA markedly induced TF mRNA, protein, and activity in vascular smooth muscle cells. LPA-induced TF expression is primarily controlled at the transcriptional level. Phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signaling-regulated kinases (ERK1/2) was rapidly and markedly induced ...


Transformation Of Non-Cancerous Human Breast Epithelial Cell Line Mcf10a By The Tobacco-Specific Carcinogen Nnk, J Mei, H Hu, Michael Mcentee, Howard Plummer, P Song, Hwa-Chain Wang Feb 2013

Transformation Of Non-Cancerous Human Breast Epithelial Cell Line Mcf10a By The Tobacco-Specific Carcinogen Nnk, J Mei, H Hu, Michael Mcentee, Howard Plummer, P Song, Hwa-Chain Wang

Howard K. Plummer III

Repeated treatments of non-cancerous human breast epithelial cells MCF10A with a low dose of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced the development of cancerous cells. NNK-transformed MCF10A cells acquired cancerous properties including anchorage-independent cell growth and increased cell motility. Cellular transformation of MCF10A cells was accompanied by a loss of responsiveness to 17beta-estradiol and decreased rate of cell proliferation. NNK-transformed MCF10A cells were also tumorigenic in immunodifficient mice. Studies of changes in the regulation of intracellular signaling pathways revealed that the upstream Erk pathway was down-regulated in the NNK-transformed cells. Our data provide the first evidence ...


Isolation Of Staphylococcus Schleiferi From Dogs With Pyoderma, Linda Frank, Stephen Kania, Keith Hnilica, Rebecca Wilkes, David Bemis Oct 2012

Isolation Of Staphylococcus Schleiferi From Dogs With Pyoderma, Linda Frank, Stephen Kania, Keith Hnilica, Rebecca Wilkes, David Bemis

Rebecca P. Wilkes DVM, PhD, DACVM

Objective—To determine frequency with which Staphylococcus schleiferi could be isolated from dogs with pyoderma and antimicrobial susceptibility patterns of isolates that were obtained. Design—Prospective study. Animals—54 dogs with a first (n = 14) or recurrent (40) episode of pyoderma. Procedure—Specimens were obtained and submitted for bacterial culture. Isolates were identified as S schleiferi on the basis of growth and biochemical characteristics. Two isolates were submitted for DNA sequencing to confirm identification. Methicillin susceptibility was determined by means of disk diffusion with oxacillin-impregnated disks. Results—3 of 14 dogs examined because of a first episode of pyoderma and ...


Isolation Of Staphylococcus Schleiferi From Dogs With Pyoderma, Linda Frank, Stephen Kania, Keith Hnilica, Rebecca Wilkes, David Bemis Aug 2012

Isolation Of Staphylococcus Schleiferi From Dogs With Pyoderma, Linda Frank, Stephen Kania, Keith Hnilica, Rebecca Wilkes, David Bemis

Stephen A Kania

Objective—To determine frequency with which Staphylococcus schleiferi could be isolated from dogs with pyoderma and antimicrobial susceptibility patterns of isolates that were obtained. Design—Prospective study. Animals—54 dogs with a first (n = 14) or recurrent (40) episode of pyoderma. Procedure—Specimens were obtained and submitted for bacterial culture. Isolates were identified as S schleiferi on the basis of growth and biochemical characteristics. Two isolates were submitted for DNA sequencing to confirm identification. Methicillin susceptibility was determined by means of disk diffusion with oxacillin-impregnated disks. Results—3 of 14 dogs examined because of a first episode of pyoderma and ...


Epoxy Impregnation Without Hardener: To Decrease Yellowing, To Delay Casting, And To Aid Bubble Removal, Rm Latorre, Robert Reed, F Gil, O Lopez-Albors, Md Ayala, F Martinez-Gomariz, Robert Henry Jul 2012

Epoxy Impregnation Without Hardener: To Decrease Yellowing, To Delay Casting, And To Aid Bubble Removal, Rm Latorre, Robert Reed, F Gil, O Lopez-Albors, Md Ayala, F Martinez-Gomariz, Robert Henry

Robert B. Reed, Jr., DVM, Ph.D.

Epoxy slices often yellow shortly after casting and the few hours following impregnation can be overwhelming as all slices need to be cast in a short period of time. A modified technique for producing epoxy slices was developed as a measure to address these problems. Tissue slices were impregnated using only epoxy polymer; no hardener was used during impregnation. The impregnated tissue slices were cast using modified casting-mixtures of epoxy polymer, hardener and glass separator. This modification of the classic E12 method (Biodur™) was done to determine: 1. If it is possible to indefinitely extend the casting time after impregnation ...


Evaluation Of The Feline Pancreas Using Computed Tomography And Radiolabeled Leukocytes., L. Head, G. Daniel, Karen Tobias, Federica Morandi, Robert Denovo Jr., Robert Donnell Mar 2012

Evaluation Of The Feline Pancreas Using Computed Tomography And Radiolabeled Leukocytes., L. Head, G. Daniel, Karen Tobias, Federica Morandi, Robert Denovo Jr., Robert Donnell

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

This study was designed to test the feasibility and utility of computed tomography and radiolabeled granulocytes in evaluating the feline pancreas in six normal cats. Autologous granulocytes were labeled with 99mTc-hexamethylpropyleneamine oxime (HMPAO) and injected into each cat. Whole body scintigraphic images were acquired at 1, 5, 15, and 30 minutes, and 1, 2, and 4 hours following injection. The following day, each cat was anesthetized and computed tomographic images of the abdomen were acquired both pre- and post-contrast. Following CT, a surgical pancreatic biopsy was collected. Feline granulocytes were successfully labeled with 99mTc-HMPAO with a labeling efficiency of 15-42 ...


Evaluation Of The Feline Pancreas Using Computed Tomography And Radiolabeled Leukocytes., L. Head, G. Daniel, Karen Tobias, Federica Morandi, Robert Denovo Jr., Robert Donnell Mar 2012

Evaluation Of The Feline Pancreas Using Computed Tomography And Radiolabeled Leukocytes., L. Head, G. Daniel, Karen Tobias, Federica Morandi, Robert Denovo Jr., Robert Donnell

Federica Morandi

This study was designed to test the feasibility and utility of computed tomography and radiolabeled granulocytes in evaluating the feline pancreas in six normal cats. Autologous granulocytes were labeled with 99mTc-hexamethylpropyleneamine oxime (HMPAO) and injected into each cat. Whole body scintigraphic images were acquired at 1, 5, 15, and 30 minutes, and 1, 2, and 4 hours following injection. The following day, each cat was anesthetized and computed tomographic images of the abdomen were acquired both pre- and post-contrast. Following CT, a surgical pancreatic biopsy was collected. Feline granulocytes were successfully labeled with 99mTc-HMPAO with a labeling efficiency of 15-42 ...


Detection Of Feline Coronavirus Infection In Southern African Nondomestic Felids, Melissa Kennedy, Stephen Kania, E Stylianides, H Bertschinger, D Keet, M Van Vuuren Mar 2012

Detection Of Feline Coronavirus Infection In Southern African Nondomestic Felids, Melissa Kennedy, Stephen Kania, E Stylianides, H Bertschinger, D Keet, M Van Vuuren

Stephen A Kania

Feline coronavirus (FCoV) infects members of the Felidae family with results ranging from seroconversion with no disease to fatal feline infectious peritonitis (FIP). Infection of non-domestic felids with FCoV is of concern, particularly in endangered populations such as cheetahs (Acinonyx jubatus). In this investigation, we tested 342 animals in the Republic of South Africa and Namibia, including 140 animals from wild populations, for evidence of FCoV infection by serology and/or reverse transcription/nested polymerase chain reaction (RT/nPCR) on feces from 1999 through 2001. Past or current infection was evaluated. Of these, 195 animals had evidence of infection and ...


Quantitative Renal Scintigraphy In Domestic Pigeons (Columba Livia Domestica) Exposed To Toxic Doses Of Gentamicin, Kemba Marshall, Linden Craig, Michael Jones, Gregory Daniel Feb 2012

Quantitative Renal Scintigraphy In Domestic Pigeons (Columba Livia Domestica) Exposed To Toxic Doses Of Gentamicin, Kemba Marshall, Linden Craig, Michael Jones, Gregory Daniel

Linden E. Craig DVM, Ph.D., DACVP, College of Veterinary Medicine

Objective—To standardize techniques for renal scintigraphy in birds, to use scintigraphy to assess gentamicin nephrotoxicosis in birds, to compare nuclear medicine assessments with histologic assessment of gentamicin nephrotoxicosis and serum uric acid concentrations, and to determine the radiopharmaceutical that best quantifies avian renal function.

Animals—12 domestic pigeons (Columba livia domestica).

Procedure—Serum uric acid concentrations were determined for all birds. Renal scintigraphy techniques that used technetium-m99 (99mTc)-dimercaptosuccinic acid (DMSA; 4 hours after injection) and 99mTc-diethylenetriamine pentaacetic acid (DTPA; 15-minute dynamic study) were evaluated in all birds. Renal biopsy specimens were collected following baseline scans. Number ...


Cloning Adult Farm Animals: A Review Of The Possibilities And Problems Associated With Somatic Cell Nuclear Transfer, J Edwards, F Schrick, M Mccracken, Sarel Van Amstel, Fred Hopkins, Matt Welborn, C Davies Jan 2012

Cloning Adult Farm Animals: A Review Of The Possibilities And Problems Associated With Somatic Cell Nuclear Transfer, J Edwards, F Schrick, M Mccracken, Sarel Van Amstel, Fred Hopkins, Matt Welborn, C Davies

Sarel R Van Amstel BVSc, Dip Med Vet, M MED VET, DACVIM

In 1997, Wilmut et al. announced the birth of Dolly, the first ever clone of an adult animal. To date, adult sheep, goats, cattle, mice, pigs, cats and rabbits have been cloned using somatic cell nuclear transfer. The ultimate challenge of cloning procedures is to reprogram the somatic cell nucleus for development of the early embryo. The cell type of choice for reprogramming the somatic nucleus is an enucleated oocyte. Given that somatic cells are easily obtained from adult animals, cultured in the laboratory and then genetically modified, cloning procedures are ideal for introducing specific genetic modifications in farm animals ...


Leadership And Training In Mental Health, Bruce Levin, Ardis Hanson, Sara Kuppin Oct 2011

Leadership And Training In Mental Health, Bruce Levin, Ardis Hanson, Sara Kuppin

Bruce Lubostsky Levin, DrPH, MPH

The leadership function within mental health organizations continues to demand that professionals must understand and deal with current multidimensional problems in the managed behavioral health care industry. Furthermore, the responsibility for preparing these professionals rests within universities to better educate these leaders in public health issues and in basic health and mental health administration. In addition, the responsibility also rests with professional societies to better equip leaders within mental health organizations for the diverse challenges that lie ahead in a changing managed behavioral health care environment. This chapter will examine leadership issues in mental health, discussing the obstacles and challenges ...


Overview Of Mental Health Services, Bruce Levin, Ardis Hanson Oct 2011

Overview Of Mental Health Services, Bruce Levin, Ardis Hanson

Bruce Lubostsky Levin, DrPH, MPH

This chapter examines the organization and delivery of mental health services in the United States from a public health perspective. This chapter will emphasize the need for mental health administrators to understand the external health care environment and the resulting impact changes in that environment has upon the functioning of their mental health agency. Because of the complex and continuous changes taking place in the field of mental health administration and behavioral health services, the management of mental health organizations should include the study of health policy and health services delivery issues in the external as well as internal organizational ...


Critical Issues In Mental Health, Ardis Hanson, Bruce Levin Oct 2011

Critical Issues In Mental Health, Ardis Hanson, Bruce Levin

Bruce Lubostsky Levin, DrPH, MPH

In 1999, the first Surgeon General's report on mental health was published by the United States Department of Health and Human Services. This landmark report summarized the epidemiology, treatment, financing, and service delivery issues in mental health. While the report focused on the major issues in the organization, financing, and provision of mental health services, there remain additional issues of importance for mental health administrators. This overview section of the text consists of five basic chapters of interest to mental health administrators at all levels of management: critical issues in mental health; an overview of mental health services delivery ...


Introduction: Technology, Organizational Change And Virtual Libraries, Ardis Hanson, Bruce Levin, Susan Heron, Merilyn Burke Oct 2011

Introduction: Technology, Organizational Change And Virtual Libraries, Ardis Hanson, Bruce Levin, Susan Heron, Merilyn Burke

Bruce Lubostsky Levin, DrPH, MPH

Change has become a way of life for most organizations in the 21st century. In order to withstand profound change, an organisation must be flexible and incorporate the ability to adapt and respond to its external environment and its many stakeholders. At the same time, in an era of increasing fiscal constraints, new technologies, and an explosion of information, informatics plays an increasingly important and prominent role in society, in knowledge exchange, in communication, and in commerce between organizations. Accordingly, the most remarkable opportunities and challenges have emerged within academic libraries with regard to the incorporation of technology into daily ...


Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson Oct 2011

Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson

Bruce Lubostsky Levin, DrPH, MPH

The revolutionary changes in the educational curriculum for schools of library and information science being evinced by the exponential expansion of computer-based technologies require a reexamination of the skills and expertise needed to be acquired by the next wave of academic librarians. This is critical in order that they may continue to be able to provide information services and resources to the academic communities within which those librarians will practice their profession. In addition, it is important to meet emerging educational needs in terms of various multiculturalism and diversity issues that are arising today as well as a thorough understanding ...


Cardiopulmonary And Anesthetic Effects Of Isoflurane And Propofol In Hispaniolan Amazon Parrots (Amazona Ventralis), Isabelle Langlois, Ralph Harvey, Michael Jones, Juergen Schumacher Aug 2011

Cardiopulmonary And Anesthetic Effects Of Isoflurane And Propofol In Hispaniolan Amazon Parrots (Amazona Ventralis), Isabelle Langlois, Ralph Harvey, Michael Jones, Juergen Schumacher

Juergen P. Schumacher

The cardiopulmonary and anesthetic effects of isoflurane and propofol were determined in 10 healthy, adult Hispaniolan Amazon parrots (Amazona ventralis). Anesthesia was induced and maintained with isoflurane in oxygen for 30 minutes. Cardiopulmonary parameters including heart rate, respiratory rate, relative arterial oxygen hemoglobin saturation (SpO2), and esophageal temperature were recorded at 1, 2, 3, 4, 5, 10, 15, 20, 25, and 30 minutes. End-tidal CO2 (EtCO2) concentrations and inspired and expired end-tidal isoflurane concentrations were recorded continuously. Before the study continued, birds were allowed to recover from isoflurane anesthesia for at least 2 hours. In a second trial, anesthesia was ...


Effects Of Lipopolysaccharide And Phenylbutazone On Gastric Contents In The Horse, Thomas Doherty, Frank Andrews, James Blackford, Barton Rohrbach, A Sandin, Arnold Saxton Aug 2011

Effects Of Lipopolysaccharide And Phenylbutazone On Gastric Contents In The Horse, Thomas Doherty, Frank Andrews, James Blackford, Barton Rohrbach, A Sandin, Arnold Saxton

Thomas J Doherty

Reasons for performing study: Endotoxaemia causes a disruption of gastrointestinal motility in the horse but there is no information on its effects on gastric secretion. Lipopolysaccharide (LPS) administration is known to affect gastric secretion in other species. Hypothesis: That LPS, a toxic component of Gram-negative bacteria, would reduce gastric acid secretion and that pretreatment with phenylbutazone (PBZ) would block the effects of LPS. Methods: The effects of LPS and PBZ on gastric contents were investigated in fasted, mature horses, with permanent gastric cannulae. Horses were pretreated with either saline or PBZ 15 min before a 60 min infusion of either ...


Effects Of Lipopolysaccharide And Phenylbutazone On Gastric Contents In The Horse, Thomas Doherty, Frank Andrews, James Blackford, Barton Rohrbach, A Sandin, Arnold Saxton Jul 2011

Effects Of Lipopolysaccharide And Phenylbutazone On Gastric Contents In The Horse, Thomas Doherty, Frank Andrews, James Blackford, Barton Rohrbach, A Sandin, Arnold Saxton

James T. Blackford DVM, MS, DACVS

Reasons for performing study: Endotoxaemia causes a disruption of gastrointestinal motility in the horse but there is no information on its effects on gastric secretion. Lipopolysaccharide (LPS) administration is known to affect gastric secretion in other species. Hypothesis: That LPS, a toxic component of Gram-negative bacteria, would reduce gastric acid secretion and that pretreatment with phenylbutazone (PBZ) would block the effects of LPS. Methods: The effects of LPS and PBZ on gastric contents were investigated in fasted, mature horses, with permanent gastric cannulae. Horses were pretreated with either saline or PBZ 15 min before a 60 min infusion of either ...


Association Of Breed With The Diagnosis Of Congenital Portosystemic Shunts In Dogs: 2400 Cases (1980-2002), Karen Tobias, Barton Rohrbach Jun 2011

Association Of Breed With The Diagnosis Of Congenital Portosystemic Shunts In Dogs: 2400 Cases (1980-2002), Karen Tobias, Barton Rohrbach

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Objective: To determine the annual and overall proportion of diagnoses of congenital portosystemic shunts (CPSS) in dogs and identify breeds at increased risk for CPSS. Design: Retrospective study. Animals: 2400 dogs with CPSS from veterinary teaching hospitals that reported to the Veterinary Medical Database (VMDB) from 01 January 1980 to 28 February 2002. Procedure: The proportion of diagnoses of CPSS was calculated for all dogs and each breed recorded in the VMDB annually and for the 22.2-year period. Odds ratios and adjusted confidence intervals were calculated for breeds with at least 100 accessions by comparing odds of each breed ...


Introduction: Technology, Organizational Change And Virtual Libraries, Ardis Hanson, Bruce Levin, Susan Heron, Merilyn Burke May 2011

Introduction: Technology, Organizational Change And Virtual Libraries, Ardis Hanson, Bruce Levin, Susan Heron, Merilyn Burke

Merilyn S Burke

Change has become a way of life for most organizations in the 21st century. In order to withstand profound change, an organisation must be flexible and incorporate the ability to adapt and respond to its external environment and its many stakeholders. At the same time, in an era of increasing fiscal constraints, new technologies, and an explosion of information, informatics plays an increasingly important and prominent role in society, in knowledge exchange, in communication, and in commerce between organizations. Accordingly, the most remarkable opportunities and challenges have emerged within academic libraries with regard to the incorporation of technology into daily ...


Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson May 2011

Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson

Merilyn S Burke

The revolutionary changes in the educational curriculum for schools of library and information science being evinced by the exponential expansion of computer-based technologies require a reexamination of the skills and expertise needed to be acquired by the next wave of academic librarians. This is critical in order that they may continue to be able to provide information services and resources to the academic communities within which those librarians will practice their profession. In addition, it is important to meet emerging educational needs in terms of various multiculturalism and diversity issues that are arising today as well as a thorough understanding ...


Mental Health Of Incarcerated Juveniles In Nevada: Final Report, Nevada Institute For Children's Rerearch And Policy, University Of Nevada, Las Vegas, Jennifer Petsonius, Denise Tanata, Michelle Chino Dr Dec 2003

Mental Health Of Incarcerated Juveniles In Nevada: Final Report, Nevada Institute For Children's Rerearch And Policy, University Of Nevada, Las Vegas, Jennifer Petsonius, Denise Tanata, Michelle Chino Dr

Nevada Institute for Children's Research and Policy Reports

The prevalence of mental health problems in the juvenile offender population is substantially higher than that of the general population (Cocozza & Skowyra, 2000). Studies estimate that one in five juvenile offenders has serious mental health problems, which is nearly twice the rate of occurrence of mental illness in children and adults in the general population (NMHA Fact Sheet #l). However, there have been several methodological problems encountered in previous research. These include the use of inconsistent definitions and measurements of mental illness; the use of biased, nonrandom samples, a reliance on retrospective case report data, and the use of non-standard measurement instruments (Coccozza & Skowyra, 2000).

All these factors can cause confusion on the actual prevalence rates of mental illness in the juvenile offender population. From other studies, tentative estimates of specific disorders prevalent among incarcerated youth are as follows: "50-90% with conduct disorder, up to 46% with attention deficit disorder, 6-41%with anxiety disorders, 25-50%with substance abuse or dependence, 32-78 ...


Patient Handling Ergonomics, Paul Reichert Dec 2003

Patient Handling Ergonomics, Paul Reichert

Theses

The incidence of musculoskeletal injuries among healthcare workers has been well documented in the medical and ergonomic literature. The epidemiological evidence demonstrates high injury rate among nurses, nurse's aides, therapists and other medical workers who frequently handle patients. The biomechanical research has shown large compressive forces developed in the lumbar spine performing various patient handling transfers that exceed the National Institute of Occupational Safety and Health's recommended guideline. One of the most strenuous patient handling tasks is transferring the patient from bed to the chair and vice versa.

One of the objectives of this thesis is to design ...


Nonmuscle Myosin Iib Is Involved In The Guidance Of Fibroblast Migration, Chun-Min Lo, Denis B. Buxton, Gregory C. H. Chua, Micah Dembo, Robert S. Adelstein, Yu-Li Wang Dec 2003

Nonmuscle Myosin Iib Is Involved In The Guidance Of Fibroblast Migration, Chun-Min Lo, Denis B. Buxton, Gregory C. H. Chua, Micah Dembo, Robert S. Adelstein, Yu-Li Wang

Open Access Articles

Although myosin II is known to play an important role in cell migration, little is known about its specific functions. We have addressed the function of one of the isoforms of myosin II, myosin IIB, by analyzing the movement and mechanical characteristics of fibroblasts where this protein has been ablated by gene disruption. Myosin IIB null cells displayed multiple unstable and disorganized protrusions, although they were still able to generate a large fraction of traction forces when cultured on flexible polyacrylamide substrates. However, the traction forces were highly disorganized relative to the direction of cell migration. Analysis of cell migration ...


Molecular Functionalization Of Carbon Nanotubes And Use As Substrates For Neuronal Growth, Mark P. Mattson, Robert C. Haddon, Apparao M. Rao Dec 2003

Molecular Functionalization Of Carbon Nanotubes And Use As Substrates For Neuronal Growth, Mark P. Mattson, Robert C. Haddon, Apparao M. Rao

Sanders-Brown Center on Aging Faculty Patents

A cell and substrate system and nerve regeneration implant are disclosed including a carbon nanotube and a neuron growing on the carbon nanotube. Both unfunctionalized carbon nanotubes and carbon nanotubes functionalized with a neuronal growth promoting agent may be utilized in the invention. A method is also disclosed for promoting neuronal growth.


Barriers To Community Mental Health Services For Latinos: Treatment Considerations, Haig Kouyoumdjian, Byron L. Zamboanga, David J. Hansen Dec 2003

Barriers To Community Mental Health Services For Latinos: Treatment Considerations, Haig Kouyoumdjian, Byron L. Zamboanga, David J. Hansen

Faculty Publications, Department of Psychology

The underutilization of mental health services by Latinos has been a growing concern in research and clinical practice. This has become increasingly important as the population of Latinos in the United States rapidly rises and the evidence that many are not receiving needed mental health services accumulates. To provide an understanding of the issues, this article provides an overview of risk factors that may influence the mental health of Latinos and examines prevalence rates of psychopathology and service utilization trends. This article then presents a comprehensive review of the socioeconomic, cultural, and psychotherapeutic barriers that prevent Latinos from receiving community ...


Uncertainty And The Value Of Diagnostic Information With Application To Axillary Lymph Node Dissection In Breast Cancer, Giovanni Parmigiani Dec 2003

Uncertainty And The Value Of Diagnostic Information With Application To Axillary Lymph Node Dissection In Breast Cancer, Giovanni Parmigiani

Johns Hopkins University, Dept. of Biostatistics Working Papers

In clinical decision making, it is common to ask whether, and how much, a diagnostic procedure is contributing to subsequent treatment decisions. Statistically, quantification of the value of the information provided by a diagnostic procedure can be carried out using decision trees with multiple decision points, representing both the diagnostic test and the subsequent treatments that may depend on the test's results. This article investigates probabilistic sensitivity analysis approaches for exploring and communicating parameter uncertainty in such decision trees. Complexities arise because uncertainty about a model's inputs determines uncertainty about optimal decisions at all decision nodes of a ...