Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Series

Discipline
Institution
Keyword
Publication Year
Publication
File Type

Articles 1 - 30 of 91337

Full-Text Articles in Medicine and Health Sciences

A Case Analysis Of Partnered Research On Palliative Care For Refugees In Jordan And Rwanda, Sonya De Laat, Olive Wahoush, Rania Jaber, Wejdan Khater, Emmanuel Musoni, Ibraheem Abu Siam, Lisa Schwartz, Matthew Hunt, Lynda Redwood-Campbell, Laurie Elit, Elysée Nouvet, Rachel Yantzi, Kevin Bezanson, Carrie Bernard, Takhliq Amir, Ani Chénier, Gautham Krishnaraj, Corinne Schusterwallace Dec 2021

A Case Analysis Of Partnered Research On Palliative Care For Refugees In Jordan And Rwanda, Sonya De Laat, Olive Wahoush, Rania Jaber, Wejdan Khater, Emmanuel Musoni, Ibraheem Abu Siam, Lisa Schwartz, Matthew Hunt, Lynda Redwood-Campbell, Laurie Elit, Elysée Nouvet, Rachel Yantzi, Kevin Bezanson, Carrie Bernard, Takhliq Amir, Ani Chénier, Gautham Krishnaraj, Corinne Schusterwallace

Health Studies Publications

© 2021, The Author(s). Background: This case analysis describes dilemmas and challenges of ethical partnering encountered in the process of conducting a research study that explored moral and practical dimensions of palliative care in humanitarian crisis settings. Two contexts are the focus of this case analysis: Jordan, an acute conflict-induced refugee situation, and Rwanda, a protracted conflict-induced refugee setting. The study’s main goal was to better understand ways humanitarian organizations and health care providers might best support ethically and contextually appropriate palliative care in humanitarian contexts. An unintended outcome of the research was learning lessons about ethical dimensions of ...


Ketogenic Diet Effects On Inflammatory Allodynia And Ongoing Pain In Rodents, David N. Ruskin, Isabella C. Sturdevant, Livia S. Wyss, Susan A. Masino Dec 2021

Ketogenic Diet Effects On Inflammatory Allodynia And Ongoing Pain In Rodents, David N. Ruskin, Isabella C. Sturdevant, Livia S. Wyss, Susan A. Masino

Faculty Scholarship

© 2021, The Author(s). Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Growing evidence suggests that one of the ketogenic diet’s main mechanisms of action is reducing inflammation. Here, we examined the diet’s effects on experimental inflammatory pain in rodent models. Young adult rats and mice were placed on the ketogenic diet or maintained on control diet. After 3–4 weeks on their respective diets, complete Freund’s adjuvant (CFA) was injected in one hindpaw to induce inflammation; the contralateral paw was used as the control. Tactile sensitivity (von Frey ...


Early Protein Intake Predicts Functional Connectivity And Neurocognition In Preterm Born Children, Emma G. Duerden, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C. Tottman, Trecia Wouldes, Steven P. Miller, Jane E. Harding, Jane M. Alsweiler, Janene B. Biggs, Coila Bevan, Joanna M. Black, Frank H. Bloomfield, Kelly Fredell, Greg D. Gamble, Jane E. Harding, Sabine Huth, Yannan Jiang, Christine Kevan, Myra Leung, Geraint Phillips, Tanya Poppe, Jennifer A. Rogers, Heather Stewart, Benjamin S. Thompson Dec 2021

Early Protein Intake Predicts Functional Connectivity And Neurocognition In Preterm Born Children, Emma G. Duerden, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C. Tottman, Trecia Wouldes, Steven P. Miller, Jane E. Harding, Jane M. Alsweiler, Janene B. Biggs, Coila Bevan, Joanna M. Black, Frank H. Bloomfield, Kelly Fredell, Greg D. Gamble, Jane E. Harding, Sabine Huth, Yannan Jiang, Christine Kevan, Myra Leung, Geraint Phillips, Tanya Poppe, Jennifer A. Rogers, Heather Stewart, Benjamin S. Thompson

Brain and Mind Institute Researchers' Publications

© 2021, The Author(s). Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.


Accelerometer Measured Physical Activity Patterns Of Children During Segmented School Day In Abu Dhabi, Rahma Ajja, Ludmilla F. Wikkeling-Scott, Keith Brazendale, Rafiq Hijazi, Abdishakur Abdulle Dec 2021

Accelerometer Measured Physical Activity Patterns Of Children During Segmented School Day In Abu Dhabi, Rahma Ajja, Ludmilla F. Wikkeling-Scott, Keith Brazendale, Rafiq Hijazi, Abdishakur Abdulle

All Works

Background: The overwhelming majority of United Arab Emirates (UAE) school-aged children do not meet the 60 min per day recommendation of moderate-to-vigorous physical activity (MVPA). Understanding the different school day segments contribution to children reaching this goal is a crucial step toward developing successful strategies to promote school day MVPA levels. This study aimed to objectively measure children’s’ physical activity levels and to examine the difference in physical activity levels between high active and low active children during the school day in Abu Dhabi. Methods: A total of 133 school children (56% boys; mean age 10.5 years; grades ...


The Dynamics Of Covid-19 In The Uae Based On Fractional Derivative Modeling Using Riesz Wavelets Simulation, Mutaz Mohammad, Alexander Trounev, Carlo Cattani Dec 2021

The Dynamics Of Covid-19 In The Uae Based On Fractional Derivative Modeling Using Riesz Wavelets Simulation, Mutaz Mohammad, Alexander Trounev, Carlo Cattani

All Works

© 2021, The Author(s). The well-known novel virus (COVID-19) is a new strain of coronavirus family, declared by the World Health Organization (WHO) as a dangerous epidemic. More than 3.5 million positive cases and 250 thousand deaths (up to May 5, 2020) caused by COVID-19 and has affected more than 280 countries over the world. Therefore studying the prediction of this virus spreading in further attracts a major public attention. In the Arab Emirates (UAE), up to the same date, there are 14,730 positive cases and 137 deaths according to national authorities. In this work, we study a ...


Vitamin D Status And Blood Pressure In Children And Adolescents: A Systematic Review Of Observational Studies, Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub, Suzan Haidar Dec 2021

Vitamin D Status And Blood Pressure In Children And Adolescents: A Systematic Review Of Observational Studies, Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub, Suzan Haidar

All Works

© 2021, The Author(s). Background: Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the literature on the relationship between vitamin D status and blood pressure (BP) in children and adolescents. Methods: Following the PRISMA guidelines, PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, and ClinicalTrials.gov and the gray literature without language or time restrictions were searched. We included observational studies, assessed their risk of bias, and extracted data on population characteristics, vitamin D status and BP measurements, and the association between the two ...


Characterizing Individuals Accessing Mental Health Services In The Uae: A Focus On Youth Living In Dubai, Mariapaola Barbato, Shaikha Al Hemeiri, Shorouk Nafie, Baraa A. Dhuhair, Nadia T. Dabbagh Dec 2021

Characterizing Individuals Accessing Mental Health Services In The Uae: A Focus On Youth Living In Dubai, Mariapaola Barbato, Shaikha Al Hemeiri, Shorouk Nafie, Baraa A. Dhuhair, Nadia T. Dabbagh

All Works

Background: Most mental health issues develop during adolescence, therefore identifying youth mental health needs and pathways to care is critical to improve prevention. To date, studies have typically focused on Western samples, while the impact of cultural diversity on perception of health and illness, and pathways to care, remain poorly understood. To address the shortage of studies conducted in the Arab world, and particularly in the United Arab Emirates (UAE), the present investigation aims to identify the characteristics of youth accessing mental health services in Dubai. Methods: Data was collected retrospectively from patients’ records at Rashid Hospital Child Psychiatry Service ...


Differential Ketogenic Diet-Induced Shift In Csf Lipid/Carbohydrate Metabolome Of Pediatric Epilepsy Patients With Optimal Vs. No Anticonvulsant Response: A Pilot Study, Susan A. Masino, David N. Ruskin, Natalie R. Freedgood, Marie Lindefeldt, Maria Dahlin Dec 2021

Differential Ketogenic Diet-Induced Shift In Csf Lipid/Carbohydrate Metabolome Of Pediatric Epilepsy Patients With Optimal Vs. No Anticonvulsant Response: A Pilot Study, Susan A. Masino, David N. Ruskin, Natalie R. Freedgood, Marie Lindefeldt, Maria Dahlin

Faculty Scholarship

Background: The low carbohydrate, high fat ketogenic diet can be an effective anticonvulsant treatment in some pediatric patients with pharmacoresistant epilepsy. Its mechanism(s) of action, however, remain uncertain. Direct sampling of cerebrospinal fluid before and during metabolic therapy may reveal key changes associated with differential clinical outcomes. We characterized the relationship between seizure responsiveness and changes in lipid and carbohydrate metabolites. Methods: We performed metabolomic analysis of cerebrospinal fluid samples taken before and during ketogenic diet treatment in patients with optimal response (100% seizure remission) and patients with no response (no seizure improvement) to search for differential diet effects ...


A Critical Narrative Inquiry To Understand The Impacts Of An Overdose Prevention Site On The Lives Of Site Users, Abe Oudshoorn, Michelle Sangster Bouck, Melissa Mccann, Shamiram Zendo, Helene Berman, Jordan Banninga, Marlene J. Le Ber, Zayya Zendo Dec 2021

A Critical Narrative Inquiry To Understand The Impacts Of An Overdose Prevention Site On The Lives Of Site Users, Abe Oudshoorn, Michelle Sangster Bouck, Melissa Mccann, Shamiram Zendo, Helene Berman, Jordan Banninga, Marlene J. Le Ber, Zayya Zendo

Nursing Publications

© 2021, The Author(s). Background: Globally, communities are struggling to gain support for harm reduction strategies being implemented to address the impacts of substance use. A key part of this discussion is understanding and engaging with people who use drugs to help shape community harm reduction strategies. This study focused on how an overdose prevention site has influenced the lives of people who use drugs. Methods: A critical narrative method was utilized, centred on photo-narratives. Twenty-seven individuals accessing an overdose prevention site were recruited to participate in preliminary interviews. Sixteen participants subsequently took photographs to describe the impact of the ...


Milk Exosomes: Nature's Abundant Nanoplatform For Theranostic Applications, Benilde Adriano, Nycol Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu Aug 2021

Milk Exosomes: Nature's Abundant Nanoplatform For Theranostic Applications, Benilde Adriano, Nycol Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications and Presentations

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus ...


Stream Sediment Monitoring In Morehead Kentucky, Kristopher Krolikowski, Jen O'Keefe Jul 2021

Stream Sediment Monitoring In Morehead Kentucky, Kristopher Krolikowski, Jen O'Keefe

2021 Celebration of Student Scholarship - Oral Presentations

Sediment loads in stream systems play a big role in how overall runoff behaves. Streams naturally transport sediment at various ratios depending on precipitation. When vegetation is removed in upstream environments, sediment loads on streams increase. Sudden increases of sediments in streams can cause many issues, such as flooding or stream re-direction. In Morehead, KY, large-scale logging operations on the ridge above Knapp Avenue and on the ridge above the north end of Allen Avenue have caused increased sediment load in a small stream called Oxley Branch. This stream flows south parallel to Knapp Avenue and along the eastern property ...


The Nature And Role Of Perceived Threats In User Resistance To Healthcare Information Technology: A Psychological Reactance Theory Perspective, Madison N. Ngafeeson, Joseph A. Manga Jul 2021

The Nature And Role Of Perceived Threats In User Resistance To Healthcare Information Technology: A Psychological Reactance Theory Perspective, Madison N. Ngafeeson, Joseph A. Manga

Information Systems Faculty Publications and Presentations

The efforts of the United States government in the past 15 years have included harnessing the power of health information technology (HIT) to improve legibility, lessen medical errors, keep costs low, and elevate the quality of healthcare. However, user resistance is still a barrier to overcome in order to achieve desired outcomes. Understanding the nature of resistance is key to successfully increasing the adoption of HIT systems. Previous research has showed that perceived threats are a significant antecedent of user resistance; however, its nature and role have remained vastly unexplored. This study uses the psychological reactance theory to explain both ...


Greater Belief In Science Predicts Mask-Wearing Behavior During Covid-19, Morgan D. Stosic, Shelby Helwig, Mollie A. Ruben Jul 2021

Greater Belief In Science Predicts Mask-Wearing Behavior During Covid-19, Morgan D. Stosic, Shelby Helwig, Mollie A. Ruben

Teaching, Learning & Research Documents

Coronavirus disease (COVID-19) pandemic impacted both the physical and psychological aspects of people's lives. Personality traits are one of the factors that explain the diverse responses to stressful situations. This study aimed to investigate whether five-factor and maladaptive personality traits are associated with depressive and anxiety symptoms, suicide risk, self-reported COVID-19 symptoms, and preventive behaviors during the COVID-19 pandemic, comprehensively.


Human Kit+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma., Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Richard S. Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K P Oliveira, Victor G Wang, Jeffrey Chuang, Paul Robson, Jacques Banchereau, Karolina Palucka Jun 2021

Human Kit+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma., Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Richard S. Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K P Oliveira, Victor G Wang, Jeffrey Chuang, Paul Robson, Jacques Banchereau, Karolina Palucka

Faculty Research 2021

Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma is dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising <4% of the human CD45+ leukocytes. Metastatic tumor-infiltrating CD33+ cells from patients and humanized (h)NSG-SGM3 mice showed converging transcriptional profiles. Single-cell RNA-seq analysis identified a gene signature of a KIT/CD117-expressing CD33+ subset that correlated with decreased overall survival in a TCGA melanoma cohort. Thus, human CD33+CD11b+CD117+ myeloid cells represent a novel candidate biomarker as well as a therapeutic target for metastatic melanoma.


Changes In Student Behaviors And Policy Opinion Regarding E-Cigarettes At A Kentucky University From 2014 To 2018, Jason W. Marion, Alina Strand, Elliott Baldridge Jun 2021

Changes In Student Behaviors And Policy Opinion Regarding E-Cigarettes At A Kentucky University From 2014 To 2018, Jason W. Marion, Alina Strand, Elliott Baldridge

EKU Faculty and Staff Scholarship

The behaviors and opinions regarding e-cigarette use and campus policies prohibiting vaping vary greatly among college students nationally. Kentucky is one of the four U.S. states with the highest tobacco use prevalence, and characterizing e-cigarette use, trends and policy opinions among Kentucky undergraduates may inform interventions. To characterize population-level differences in e-cigarette-related behaviors and policy opinions among undergraduates from 2014 to 2018, results from two cross-sectional surveys (2014 and 2018) from a public regional university in south-central Kentucky were analyzed. Students from randomly selected undergraduate general studies courses completed a 5-minute in-class survey. Data were obtained from 514 and ...


Sense Of Effort Is Distorted In People With Chronic Low Back Pain, Michel W. Coppieters, Jesper Andersen, Håvard Selbæk, Kjell Herland, Rahma Ajja, Harald Markussen, Paul W. Hodges Jun 2021

Sense Of Effort Is Distorted In People With Chronic Low Back Pain, Michel W. Coppieters, Jesper Andersen, Håvard Selbæk, Kjell Herland, Rahma Ajja, Harald Markussen, Paul W. Hodges

All Works

Background: Proprioceptive deficits in people with low back pain (LBP) have traditionally been attributed to altered paraspinal muscle spindle afference and its central processing. Studies conducted in the upper limb demonstrated that sense of effort is also an important source of kinaesthetic information. Objectives: To better understand proprioceptive deficits in people with chronic LBP (cLBP), this study aimed to test whether sense of effort is affected in people with cLBP. Design: Cross-sectional study. Method: Fourteen participants with cLBP and fourteen healthy participants performed a 120 s force matching task with their trunk extensor muscles at a low intensity. Results: When ...


Characterization Of Time-Variant And Time-Invariant Assessment Of Suicidality On Reddit Using C-Ssrs, Manas Gaur, Vamsi Aribandi, Amanuel Alambo, Ugur Kursuncu, Krishnaprasad Thirunarayan, Jonathan Beich, Jyotishman Pathak, Amit Sheth May 2021

Characterization Of Time-Variant And Time-Invariant Assessment Of Suicidality On Reddit Using C-Ssrs, Manas Gaur, Vamsi Aribandi, Amanuel Alambo, Ugur Kursuncu, Krishnaprasad Thirunarayan, Jonathan Beich, Jyotishman Pathak, Amit Sheth

Publications

Suicide is the 10th leading cause of death in the U.S (1999-2019). However, predicting when someone will attempt suicide has been nearly impossible. In the modern world, many individuals suffering from mental illness seek emotional support and advice on well-known and easily-accessible social media platforms such as Reddit. While prior artificial intelligence research has demonstrated the ability to extract valuable information from social media on suicidal thoughts and behaviors, these efforts have not considered both severity and temporality of risk. The insights made possible by access to such data have enormous clinical potential - most dramatically envisioned as a trigger ...


Communication In Interventional Radiology: Addressing The Challenges Of Complexity And The Impact Of Secure Text-Message Communications, Aakriti Mishra, Daniel Harwood, William Schaeffer, Anna Fabre, Emily Ochmanek, Paul Vantine, Sean Biggs, Ryan Lebaron May 2021

Communication In Interventional Radiology: Addressing The Challenges Of Complexity And The Impact Of Secure Text-Message Communications, Aakriti Mishra, Daniel Harwood, William Schaeffer, Anna Fabre, Emily Ochmanek, Paul Vantine, Sean Biggs, Ryan Lebaron

Quality Improvement/Patient Safety Symposium

Background: The utilization of smartphone-based technology to improve multidisciplinary communication and patient care provides an exciting opportunity for quality improvement research. In our institution, consult requests have traditionally been responded to verbally, in person or over the phone. Unfortunately, this is prone to communication errors and duplication of work. Approximately three years ago, our division developed a uniform consultation note that could easily be placed in the patient record. Additionally, we analyze the impact of a HIPAA compliant messaging system (“Tiger Connect™”) on communication inside and outside the interventional radiology (IR) department.

Methods and materials: The electronic health record (EHR ...


Stability Of Plasma Glucose In Whole Blood Samples Collected In Sodium Fluoride Tube Vs. Sodium Heparin Plasma Separator Tubes, Ryan C. Braunberger, Magen Martinez, David G. Grenache May 2021

Stability Of Plasma Glucose In Whole Blood Samples Collected In Sodium Fluoride Tube Vs. Sodium Heparin Plasma Separator Tubes, Ryan C. Braunberger, Magen Martinez, David G. Grenache

Quality Improvement/Patient Safety Symposium

Background: The concentration of plasma glucose is influenced by preanalytical variables such as delayed processing of whole blood. Glucose concentrations decrease by 5-7% per hour in whole blood due to glycolysis. This preanalytical loss decreases the diagnostic sensitivity of glucose when used to diagnose diabetes mellitus or gestational diabetes mellitus. Sodium fluoride (NaF) is commonly used to inhibit glycolysis in samples collected during oral glucose tolerance tests, but is inadequate as it does not stop glycolysis for two or more hours. Guidelines recommend blood samples be immediately immersed in an ice slurry and analyzed within 30 minutes of collection, but ...


Structural Alterations In Cortical And Thalamocortical White Matter Tracts After Recovery From Prefrontal Cortex Lesions In Macaques, Ramina Adam, David J. Schaeffer, Kevin Johnston, Ravi S. Menon, Stefan Everling May 2021

Structural Alterations In Cortical And Thalamocortical White Matter Tracts After Recovery From Prefrontal Cortex Lesions In Macaques, Ramina Adam, David J. Schaeffer, Kevin Johnston, Ravi S. Menon, Stefan Everling

Brain and Mind Institute Researchers' Publications

Unilateral damage to the frontoparietal network typically impairs saccade target selection within the contralesional visual hemifield. Severity of deficits and the degree of recovery have been associated with widespread network dysfunction, yet it is not clear how these behavioural and functional brain changes relate with the underlying structural white matter tracts. Here, we investigated whether recovery after unilateral prefrontal cortex (PFC) lesions was associated with changes in white matter microstructure across large-scale frontoparietal cortical and thalamocortical networks. Diffusion-weighted imaging was acquired in four male rhesus macaques at pre-lesion, week 1, and week 8-16 post-lesion when target selection deficits largely recovered ...


Mindset, Medicine And You, Gregory A. Jaffe, Md, Msed May 2021

Mindset, Medicine And You, Gregory A. Jaffe, Md, Msed

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

  • Describe the differences between a fixed and growth mindset
  • State phrases that encourage growth mindset
  • Apply growth mindset techniques to medical education


Acute Inflammatory Profiles Differ With Sex And Age After Spinal Cord Injury, Andrew N. Stewart, John L. Lowe, Ethan P. Glaser, Caitlin A. Mott, Ryan K. Shahidehpour, Katelyn E. Mcfarlane, William M. Bailey, Bei Zhang, John C. Gensel May 2021

Acute Inflammatory Profiles Differ With Sex And Age After Spinal Cord Injury, Andrew N. Stewart, John L. Lowe, Ethan P. Glaser, Caitlin A. Mott, Ryan K. Shahidehpour, Katelyn E. Mcfarlane, William M. Bailey, Bei Zhang, John C. Gensel

Physiology Faculty Publications

Background

Sex and age are emerging as influential variables that affect spinal cord injury (SCI) recovery. Despite a changing demographic towards older age at the time of SCI, the effects of sex or age on inflammation remain to be elucidated. This study determined the sex- and age-dependency of the innate immune response acutely after SCI.

Methods

Male and female mice of ages 4- and 14-month-old received T9 contusion SCI and the proportion of microglia, monocyte-derived macrophages (MDM), and neutrophils surrounding the lesion were determined at 3- and 7-day post-injury (DPI) using flow cytometry. Cell counts of microglia and MDMs were ...


A Screen Of Fda-Approved Drugs Identifies Inhibitors Of Protein Tyrosine Phosphatase 4a3 (Ptp4a3 Or Prl-3), Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn May 2021

A Screen Of Fda-Approved Drugs Identifies Inhibitors Of Protein Tyrosine Phosphatase 4a3 (Ptp4a3 Or Prl-3), Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn

Molecular and Cellular Biochemistry Faculty Publications

Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, small molecule inhibitors of PRL-3 are lacking. Here, we screened 1443 FDA-approved drugs for their ability to inhibit the activity of the PRL phosphatase family. We identified five specific inhibitors for PRL-3 as well as one selective inhibitor of PRL-2. Additionally, we found nine drugs that broadly and significantly suppressed PRL activity. Two of these broad-spectrum PRL inhibitors, Salirasib and Candesartan, blocked PRL-3-induced migration in human embryonic kidney cells ...


Polycystic Ovarian Syndrome For The Pcp, Madeline Taskier, Md May 2021

Polycystic Ovarian Syndrome For The Pcp, Madeline Taskier, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

  • Define PCOS
  • Outline varying diagnostic criteria
  • Briefly review pathophysiology and diagnostic approach
  • Review primary care management of PCOS symptoms
  • Summarize role of PCP for clinical monitoring
  • Explore influence of PCOS on fertility and pregnancy


Effects Of Social Determinants Of Health In Progression To Type 2 Diabetes, Folabi I. Ariganjoye May 2021

Effects Of Social Determinants Of Health In Progression To Type 2 Diabetes, Folabi I. Ariganjoye

Applied Research Projects

The prevalence of prediabetes and diabetes in the United States and around the world has increased faster than expected in the last 30 years. The economic burden this costs a nation can be astronomic both in terms of expense and loss in productivity. One-third of U.S. adults, 86 million people, have prediabetes. Effective management is needed that can reach these 86 million, and others at high risk, to reduce their progression to diagnosed Type 2 diabetes. After the literature review, there was not enough literature to support how these led to the progression to diabetes. The abundant literature is ...


Changes In Subjective Versus Objective Well-Being In India, Vani S. Kulkarni, Veena S. Kulkarni, Katsushi S. Imai, Raghav Gaiha May 2021

Changes In Subjective Versus Objective Well-Being In India, Vani S. Kulkarni, Veena S. Kulkarni, Katsushi S. Imai, Raghav Gaiha

Population Center Working Papers (PSC/PARC)

Although there is abundant literature on subjective well-being (SWB), there is virtually none for India. Growing recognition of the validity and accuracy of measures of SWB of well-being underlies the rapid growth of literature on SWB in recent decades but it has mainly focused on developed countries. Ours is, to our knowledge, the first study of SWB at the all-India level, and one of the few on developing countries, with a rigorous validation of the results. Applying robust OLS and ordered probit models to the India Human Development Survey (IHDS) panel data in 2005 and 2012, we assess SWB changes ...


Office Of The Vice President For Research And Dean Of The Graduate_Research Continuity Update Email, University Of Maine Office Of The Vice President For Research And Dean Of The Graduate School May 2021

Office Of The Vice President For Research And Dean Of The Graduate_Research Continuity Update Email, University Of Maine Office Of The Vice President For Research And Dean Of The Graduate School

Teaching, Learning & Research Documents

Email from the Office of Vice President for Research and Dean of the Graduate School, University of Maine regarding the fact that all research activity required notification versus approval, unless it involves domestic out-of-state and international travel, which was prohibited, unless an exception was sought and granted.


Effect Of Infant Breastfeeding Versus Formula Feeding For A Minimum Of One Month On Cognitive Outcomes In Early Childhood, Mary K. Bosson, Sarah Michelle Hodges, Madison Victoria Cavalli, Kaitlyn Grace Carmichael May 2021

Effect Of Infant Breastfeeding Versus Formula Feeding For A Minimum Of One Month On Cognitive Outcomes In Early Childhood, Mary K. Bosson, Sarah Michelle Hodges, Madison Victoria Cavalli, Kaitlyn Grace Carmichael

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Cognitive development is an important part of infant growth since intellectual predilections in infancy set enduring patterns. Evidence supports that exclusive or mixed breastfeeding for at least one month may improve general child cognition scores. Breast milk contains nutrients such as docosahexaenoic acid (DHA), arachidonic acid (AA), zinc, choline, and vitamin B12 that enhance myelination in the brain to improve cognition. Even if formula is able to be fortified with these vitamins and minerals, formula-fed infants tend to experience slower digestion with less nutrient absorption. Despite the potential nutritional gains of breastfeeding, there is a knowledge gap regarding how long ...


Rates Of Anxiety And Depression Are High Among Young Adults During Covid-19, Xiaoyan Zhang May 2021

Rates Of Anxiety And Depression Are High Among Young Adults During Covid-19, Xiaoyan Zhang

Lerner Center for Public Health Promotion: Population Health Research Brief Series

This data slice uses data from the U.S. Census Bureau Household Pulse Survey to compare the percentage of U.S. young adults (ages 18-29) who reported experiencing anxiety or depression during a two-week period in late March 2021 by race/ethnicity. The brief shows much lower rates of self-reported anxiety among Non-Hispanic Blacks than among other racial/ethnic groups but no significant racial/ethnic differences in self-reported depression.


Put Your Thoughts On Trial: Cognitive Restructuring, Yudith Ledesma May 2021

Put Your Thoughts On Trial: Cognitive Restructuring, Yudith Ledesma

Professional Impact Project: Implementation of Evidence Based Practices by Clinical Mental Health Counseling Graduate Students

For this project, I applied cognitive restructuring techniques to a patient with a substance abuse diagnosis. It incorporates role playing, psychoeducation, and Socratic questions. I describe case overview, method, and results in this PIP.