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Full-Text Articles in Medicine and Health Sciences

Prediction Of Drug-Drug Interaction Potential Using Machine Learning Approaches, Joseph Scavetta May 2020

Prediction Of Drug-Drug Interaction Potential Using Machine Learning Approaches, Joseph Scavetta

Theses and Dissertations

Drug discovery is a long, expensive, and complex, yet crucial process for the benefit of society. Selecting potential drug candidates requires an understanding of how well a compound will perform at its task, and more importantly, how safe the compound will act in patients. A key safety insight is understanding a molecule's potential for drug-drug interactions. The metabolism of many drugs is mediated by members of the cytochrome P450 superfamily, notably, the CYP3A4 enzyme. Inhibition of these enzymes can alter the bioavailability of other drugs, potentially increasing their levels to toxic amounts. Four models were developed to predict CYP3A4 ...


Food Safety Risk In An Indoor Microgreen Cultivation System, Gina Marie Misra May 2020

Food Safety Risk In An Indoor Microgreen Cultivation System, Gina Marie Misra

Theses and Dissertations

Microgreens are immature sprouts of edible plants, sharing some similarities with sprouted seeds and petite leafy greens. Since they are most often grown in containers in buildings or greenhouses, they present a new area for food safety research at the intersection of the built environment and produce farming. Contamination by human pathogens has been extensively studied in other types of produce typically eaten raw, including sprouted seeds, which have been implicated in numerous outbreaks of salmonellosis over the last several decades. There is a paucity of knowledge about the microgreen sector of the fresh-cut industry; thus, it was determined that ...


An Experimental Test Of The Effects Of Sleep Deprivation On Approach Behavior, Rebecca L. Campbell May 2020

An Experimental Test Of The Effects Of Sleep Deprivation On Approach Behavior, Rebecca L. Campbell

Theses and Dissertations

Emotion regulation and sleep have been identified as mechanisms that may be involved in the development and maintenance of many mental health disorders. However, there has been little research into the relation between sleep and emotion regulation. To address this gap in knowledge, a novel study was conducted. We hypothesized that sleep deprived individuals would demonstrate less approach behavior toward a negatively valenced stimulus, as well as increased self-reported avoidance, compared to a control group. To test this, a randomized controlled experiment using a behavioral measure of approach and a self-report measure of avoidance was conducted. Fifty-two healthy individuals ages ...


Calling Out The Trolls: Responses To Witnessing Use Of The “Troll” Label As A Defense In An Online Group Context, Dene E. M. Wamsley May 2020

Calling Out The Trolls: Responses To Witnessing Use Of The “Troll” Label As A Defense In An Online Group Context, Dene E. M. Wamsley

Theses and Dissertations

Although the term “troll” has existed since the 1980s, its meaning has shifted in recent years as social media use has increased. People provide contrasting and imprecise definitions for what constitutes “trolling,” and often apply the term subjectively to describe online discussants who are uncivil, who are deviant, and who and present counter-attitudinal opinions. Exposure to deviance, counter-attitudinal information, and incivility often leads to unwanted psychological effects. In theory, labeling an uncivil, counter-attitudinal deviant as a “troll” proposes that their intention is to disrupt the conversation and upset other discussants, which provides a reason for why incivility is used, and ...


The Effects Of Fatigue On Lower Extremity Neuromuscular Control, Matthew Thomas Marcen Apr 2020

The Effects Of Fatigue On Lower Extremity Neuromuscular Control, Matthew Thomas Marcen

Theses and Dissertations

Lower extremity injuries and pathologies are amongst the most common issues recreational athletes face. Fatigue is a factor that may impact how the lower extremity performs on a neuromuscular level. Neuromuscular control is a vital aspect of athletic performance and everyday life, that when hindered, may produce pathological results. The research is contradictory on whether or not fatigue produces a significant impact during neuromuscular performance. The purpose of this study is to assess neuromuscular control following a lower extremity fatigue protocol.

This study was a randomized a controlled trial. Twenty-one recreationally active subjects, 10 males and 11 females, between the ...


Cardiovascular Recovery From Emotional Stress: An Operationalization Of Equanamity Following Mindfulness-Based Emotional Stress, Emma Mcbride Apr 2020

Cardiovascular Recovery From Emotional Stress: An Operationalization Of Equanamity Following Mindfulness-Based Emotional Stress, Emma Mcbride

Theses and Dissertations

Theoretical models of mindfulness suggest that meditation may improve health, in part, by regulating stress physiology, including faster recovery of heart rate (HR) and blood pressure (SBP/DBP) after emotional stress. Furthermore, improved cardiovascular recovery (CR) may be a marker of equanimity, defined as increased acceptance of and reduced reactivity to stress. No studies have tested this hypothesis, partly because methodology for assessing CR remains controversial. Using a novel operationalization of equanimity and several methods of measuring CR, this project investigated whether (1) equanimity is associated with improved CR, (2) Mindfulness-Based Stress Reduction (MBSR) is associated with improved CR, and ...


Testing Postural Control With Kinesiology Tape And A Compression Ankle Sleeve In Dancers, Sarah Catherine Unger Apr 2020

Testing Postural Control With Kinesiology Tape And A Compression Ankle Sleeve In Dancers, Sarah Catherine Unger

Theses and Dissertations

The purpose of this study is to assess if kinesiology tape (KT) and compression sleeves can influence balance and postural control by assessing center of pressure (CoP). This study will also compare the effectiveness of increasing postural control between KT and a compression sleeve. Fifteen female subjects between the ages of 18 and 22 years old volunteered to participate in this study. One subject's data was discarded due to KT disruption. The fourteen remaining subjects were randomly assigned to either the KT, compression sleeve, or control group. Each subject performed a semi-dynamic balance test (modified Airplane Test) on a ...


Plyometric Training And Its Effects On The Neuromuscular System, Bradley Andrew Martin Apr 2020

Plyometric Training And Its Effects On The Neuromuscular System, Bradley Andrew Martin

Theses and Dissertations

Plyometric training is commonly employed by athletic trainers, personal trainers, and strength and conditioning coaches, especially for those athletes who require quickness, agility, and high vertical jump performance. It is well documented in its ability to increase these aspects of performance.(12, 14, 16, 20) There are many proposed mechanisms in place which attempt to explain why it is so effective, however, many of the proposed mechanisms are still theoretical. The purpose of this study is to examine some of those proposed mechanisms that drive the success of plyometric training. This project investigates the neurological effects of plyometric training by ...


The Relationship Between The Use Of Hormonal Contraceptives And Ligamentous Knee Injury In The Female Collegiate Athlete, Nicole Michelle Thompson Apr 2020

The Relationship Between The Use Of Hormonal Contraceptives And Ligamentous Knee Injury In The Female Collegiate Athlete, Nicole Michelle Thompson

Theses and Dissertations

Female athletes are three to six times more likely than males to sustain a ligamentous knee injury due to hormonal risk factors. Hormones of the menstrual cycle have been shown to alter the physiological component of ligamentous structures during the three phases of the cycle. Use of hormonal contraceptives (HCs) may influence the incidence and severity of ligamentous knee injuries in female athletes. The objective of this cross-sectional study was to determine the relationship between HC use and the type and severity of ligamentous knee injuries sustained among female collegiate athletes using an online survey distributed to NCAA female athletes ...


Balance Of Adults With Chronic Ankle Instability Following A 6-Week Core Stability Program, Natalie Dickol Apr 2020

Balance Of Adults With Chronic Ankle Instability Following A 6-Week Core Stability Program, Natalie Dickol

Theses and Dissertations

Ankle injuries are one of the most common injuries in the athletic population because of the anatomy of the ankle in conjunction with dynamic activity. During injury, mechanoreceptors are damaged, effecting neuromuscular control. Lack of neuromuscular control puts patients at risk for re-injury. Chronic ankle instability (CAI) has been defined as a condition associated with recurrent sprains and persistent symptoms, including feelings of "giving way," loss of function and limited movement and continuous ankle pain. Patients with CAI are commonly shown to have functional deficits in postural control, such as overcompensating on the uninvolved limb or unable to maintain proper ...


Effects Of A Large Group Combined Narrative And Expository Language Intervention On Oral Language In Third Graders, Kylie Lynn Lee Apr 2020

Effects Of A Large Group Combined Narrative And Expository Language Intervention On Oral Language In Third Graders, Kylie Lynn Lee

Theses and Dissertations

The purpose of this study was to examine the effects of a combined narrative and expository language intervention on third graders' oral language. The participants included 96 third-grade students from two schools in the Mountain West region of the United States. In a quasi-experimental design, all third-grade students in one school (n = 46) were assigned to a treatment condition and all third-grade students in another school in the same school district (n = 50) were assigned to a control condition. Both treatment and control groups received large group oral narrative language intervention led by classroom teachers. The treatment group received additional ...


Impact Of Sickle Cell Disease On Executive Functioning In An Adult Population, Christina Wade Jan 2020

Impact Of Sickle Cell Disease On Executive Functioning In An Adult Population, Christina Wade

Theses and Dissertations

Children diagnosed with sickle cell disease (SCD) struggle with executive functions (EF); however, there is a paucity of research on neuropsychological outcomes in adults with SCD. This study aimed to examine differences in EF between adults with SCD and healthy controls. Thirty- one patients with SCD and 34 healthy controls (ages 18-45) participating in an IRB-approved Children’s Hospital Los Angeles (CHLA) study of cerebral blood flow underwent neuropsychological evaluation using the Delis–Kaplan Executive Function System (D-KEFS) Trail Making and Color Word Interference Tests and the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span subtest to assess various ...


From Bedside To Bench: Use Of Patient-Derived Xenograft Models To Develop Novel Therapeutic Strategies For Triple-Negative Breast Cancer, Tia H. Turner Jan 2020

From Bedside To Bench: Use Of Patient-Derived Xenograft Models To Develop Novel Therapeutic Strategies For Triple-Negative Breast Cancer, Tia H. Turner

Theses and Dissertations

Triple-negative breast cancer (TNBC) is a clinically aggressive disease that is associated with bleak outcomes due to its metastatic propensity, frequent failure to respond to chemotherapy, and lack of alternative treatment options. Despite decades of major translational research efforts, there has been very little success thus far in the development of effective targeted therapies for this disease. It is imperative to develop novel therapeutic strategies to improve patient outcomes, as well as minimize the toxicity associated with standard-of-care chemotherapeutics. Given that metastatic disease accounts for the vast majority of TNBC-related deaths, a better understanding of therapeutic responses within common sites ...


A Comparison Of Three-Dimensional Printing Technologies On The Precision, Trueness, And Accuracy Of Printed Retainers, Owais A. Naeem Jan 2020

A Comparison Of Three-Dimensional Printing Technologies On The Precision, Trueness, And Accuracy Of Printed Retainers, Owais A. Naeem

Theses and Dissertations

Purpose: The aim of this study was to evaluate the differences in the precision, trueness, and accuracy of 3D printed orthodontic clear retainers produced using printer systems with various printing technologies.

Methods: Retainers (n=15) were printed using four different 3D printers: a stereolithography (SLA) printer, two different digital light processing (DLP and cDLP) printers, and a polyjet photopolymer (PPP) printer. The 3D printed retainers were transformed into a digital file through a cone-beam computed tomography scan that was compared to the original image using a 3D superimposition analysis software. At previously chosen landmarks (R6, L6, R3, L3, R1, L1 ...


The Effects Of Exosomes On The Regeneration Of Rat Calvaria, Jill T. Beitz Jan 2020

The Effects Of Exosomes On The Regeneration Of Rat Calvaria, Jill T. Beitz

Theses and Dissertations

Periodontal disease is a bacterial induced chronic inflammatory condition that occurs in a susceptible host, affecting the teeth, gingiva, periodontal ligament, and alveolar bone. The resultant pathological bone defects often require surgical intervention, with the ultimate goal being regeneration of the periodontium through the application of grafting materials and biologics. Mesenchymal stem cells (MSCs) show great potential in regenerative medicine for their ability to enhance cell proliferation and differentiation, increase angiogenesis, and modulate the immune response. Stem cell-derived by-products, known as exosomes are a specific class of lipid-membrane-bound extracellular vesicles that are proliferative and chemotactic, are able to inhibit cytokine ...


Effects Of (R,S)-Ketamine And (2r,6r)-Hydroxynorketamine: A Preclinical Study, Remington Rice Jan 2020

Effects Of (R,S)-Ketamine And (2r,6r)-Hydroxynorketamine: A Preclinical Study, Remington Rice

Theses and Dissertations

In 2017, 7.1% of US adults were diagnosed with depression, and 50% of patients received medication to treat their depression. Depression can cause severe interruptions in an individual's cognitive functioning and behaviors like sleeping, eating, working, and socializing. Unfortunately, approximately 40% of patients do not respond to treatment with monoaminergic medications (e.g. Prozac) and therapeutic effects may be delayed 2-8 weeks. Due to these therapeutic shortcomings, faster acting and more efficacious treatments are needed. Recent preclinical findings indicate potential for glutamatergic drugs like (R,S)-ketamine and (2R,6R) hydroxynorketamine to produce more rapid and longer-acting therapeutic ...


The Effects Of Autophagy And Senescence On Sensitivity To Cisplatin In Head And Neck Cancer, Zara H. Siddiqui Jan 2020

The Effects Of Autophagy And Senescence On Sensitivity To Cisplatin In Head And Neck Cancer, Zara H. Siddiqui

Theses and Dissertations

While current treatments in cancer, such as chemotherapy and radiation, can generally be effective in eliminating disease in patients, there also exists the possibility of recurrence of cancer cells over time. In patients diagnosed with locally advanced head and neck carcinoma, about 50-60% develop a loco-regional recurrence within two years, and 20-30% of patients develop metastatic disease at distant sites in the body [5]. On a cellular level, one mechanism for this survival may be that natural mechanisms such as autophagy and senescence play a role in allowing cells to survive after undergoing treatment. One standard of care chemotherapy for ...


The Effect Of Print Angulation On The Accuracy And Precision Of 3d-Printed Orthodontic Retainers, Allison Williams Jan 2020

The Effect Of Print Angulation On The Accuracy And Precision Of 3d-Printed Orthodontic Retainers, Allison Williams

Theses and Dissertations

Purpose: The aims of this study were: 1) to compare the accuracy and precision of 3-

dimensional (3D) printed retainers at various angulations, 2) to evaluate the effect of angulation

on printing time and the amount of resin consumed.

Methods: Using a stereolithography (SLA) 3D printer, a total of 60 clear retainers were printed at five angulations (n=12, each): 15, 30, 45, 60, and 90 degrees. Six retainers were printed each cycle at a random order for all print angulations as print 1 and print 2. Digital images of the original and printed retainers were superimposed. Discrepancies on eight ...


Repeat Full Mouth Dental Rehabilitation Under General Anesthesia For Medicaid Eligible Healthy Children Who Are High Caries Risk, Lajoi E. Wiggins Jan 2020

Repeat Full Mouth Dental Rehabilitation Under General Anesthesia For Medicaid Eligible Healthy Children Who Are High Caries Risk, Lajoi E. Wiggins

Theses and Dissertations

Purpose: To evaluate the treatment of healthy children who are high caries risk and of low socioeconomic status and who require repeat full mouth dental rehabilitation (FMDR) under general anesthesia (GA).

Methods: A retrospective chart review was performed on healthy Medicaid eligible patients who were initially between 18 months - 6 years of age who underwent FMDR under GA in the OR more than once at the Virginia Commonwealth University (VCU) School of Dentistry, Department of Pediatric Dentistry from January 2008 to December 2018. Biographical information for each patient was gathered into a REDCap™ Survey. Statistical analysis, chi-squared test with a ...


Exploring The Heteromeric Interface Of The 5-Ht2a-Mglu2 Receptor Complex, Mohamed Aarif Abdul Kareem Jan 2020

Exploring The Heteromeric Interface Of The 5-Ht2a-Mglu2 Receptor Complex, Mohamed Aarif Abdul Kareem

Theses and Dissertations

Schizophrenia is a serious mental disorder characteristic of several neurotransmitters including dopamine, serotonin, and glutamate being in imbalance. Early therapies focused solely on dopamine antagonism and second-generation antipsychotics focused on the dopamine and serotonin systems and their respective G protein coupled receptor (GPCR) proteins. Although debate for dimerization of certain classes of GPCR exist, the establishment of an mGlu2-5-HT2A heterocomplex, which is implicated in schizophrenia is of interest. Previous studies have used a mutation-based approach to identify transmembrane domain 4 (TM4) as the domain responsible in mGlu2 for mediating heteromerization before narrowing down the individual amino acids responsible for ...


Process Factors Affecting Reperfusion Time In Patients Presenting With St-Segment Elevation Myocardial Infarction (Stemi), Richard R. Wall Jan 2020

Process Factors Affecting Reperfusion Time In Patients Presenting With St-Segment Elevation Myocardial Infarction (Stemi), Richard R. Wall

Theses and Dissertations

Abstract PROCESS FACTORS AFFECTING REPERFUSION TIME IN PATIENTS

PRESENTING WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI) By Richard R. Wall MSRS, RT(R)(CT)(CI), RCIS

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2020.

Dissertation Chair: Jeffrey S. Legg Ph.D. Associate Professor and Chair, Department of Radiation Sciences

An ST-segment myocardial infarction (STEMI) occurs when the blood flow to the myocardium is suddenly and completely blocked causing the myocardium to become ischemic. A STEMI is a life-threatening condition that necessitates emergent medical treatment. Research ...


A Comparison In Pediatric Dental Website Design From A Guardian And Pediatric Dentists’ Perspective., David M. Voth Jan 2020

A Comparison In Pediatric Dental Website Design From A Guardian And Pediatric Dentists’ Perspective., David M. Voth

Theses and Dissertations

Purpose: This project aims to determine which aspects of pediatric dental practice websites are preferable to the guardians of pediatric dental patients and which of these aspects are currently available to guardians on the websites of pediatric dental practices across the United States. The comparison will reveal if practice websites are meeting the needs of the guardians of pediatric dental patients. Our hope is to provide meaningful guidance to pediatric dentists designing new practice websites and to provide the guardians of pediatric dental patients with an appealing online experience during their use of the aforementioned websites. Methods: A survey with ...


A Theoretically-Based Mixed Methods Approach To Examining Mental Health Disorders And Help-Seeking Behaviors Among University-Enrolled African American Men, Kofoworola D.A. Williams Jan 2020

A Theoretically-Based Mixed Methods Approach To Examining Mental Health Disorders And Help-Seeking Behaviors Among University-Enrolled African American Men, Kofoworola D.A. Williams

Theses and Dissertations

Recent studies show that African American men in college are disproportionately experiencing high levels of psychological distress, increasing their risk of developing mental health symptoms associated with depression and anxiety. Despite being at higher risk for developing mental health symptoms, university-enrolled, African American men are not seeking help even when experiencing high levels of stress and anxiety, impacting their academic performance. The evidence base describing mental health symptom prevalence and evidence-based prevention strategies among university-enrolled, African American men is limited. To that end, this dissertation work utilized a concurrent, mixed methods approach, theoretically-based in the Social Ecological Model (SEM), to ...


Examining Body Mass Index And Sepsis Mortality At One Year After Sepsis, Jamie D. Robinson Jan 2020

Examining Body Mass Index And Sepsis Mortality At One Year After Sepsis, Jamie D. Robinson

Theses and Dissertations

Introduction: Sepsis is a serious and life-threatening syndrome affecting 1.7 million Americans annually and resulting in approximately 270,000 deaths. An “obesity paradox” where obese individuals have lower sepsis mortality than their non-obese counterparts has been described. The problem is that the longevity of the effect is unknown, and few studies have examined the obesity paradox after 1-2 months post-diagnosis.

Methods: This retrospective cohort study examined clinical, demographic, and biomarker variables thought to affect sepsis mortality at three-time points: 30 days, 180 days, and at one year post-sepsis diagnosis in order to shed light on specific factors that might ...


In Vivo Effects Of The Cb1 Allosteric Modulator Ldk1258, A Structural Analog Of Org-27569, Mohammed A. Mustafa Jan 2020

In Vivo Effects Of The Cb1 Allosteric Modulator Ldk1258, A Structural Analog Of Org-27569, Mohammed A. Mustafa

Theses and Dissertations

CB1 receptor allosteric modulators are an area of growing interest for their potential novel therapeutic actions. In the present study, we examined LDK1258 in a series of pharmacological in vivo tests sensitive to CB1 receptor stimulation. In the tetrad assay, LDK1258 produced significant decreases in locomotor activity and body temperature measures but did not produce either antinociception as measured in the tail-withdrawal assay or catalepsy as assessed in the bar test. These same effects were observed in both CB1 (-/-) and (+/+) mice. Moreover, LDK1258 failed to shift the dose-response curves of two orthosteric CB1 receptor agonists in the triad assay. In ...


A Qualitative Analysis Of Caregiver Goals For Urban Children With And Without Asthma, Megan M. Carlson Jan 2020

A Qualitative Analysis Of Caregiver Goals For Urban Children With And Without Asthma, Megan M. Carlson

Theses and Dissertations

Pediatric asthma is a major public health concern that disproportionately affects children of color and youth living in low-income, urban areas. The implications for public health, child health, and family functioning necessitates our understanding and addressing experiences by families who are facing barriers within their socio-demographic context in addition to the stressors associated with managing pediatric asthma. The current study applied qualitative methods to interviews with caregivers of children with and without asthma in an effort to more deeply connect with caregivers’ experiences and yield richer information about the intersection of identities as Black caregivers living in an urban setting ...


Characterization Of The Gonococcal Calprotectin Zn-Acquisition System, Tdfh, And The Efficacy Of Metal Starvation For Treating Gonococcal Disease, Michael T. Kammerman Jan 2020

Characterization Of The Gonococcal Calprotectin Zn-Acquisition System, Tdfh, And The Efficacy Of Metal Starvation For Treating Gonococcal Disease, Michael T. Kammerman

Theses and Dissertations

Abstract

Characterization of the Gonococcal Calprotectin Zn-Acquisition System, TdfH, and the Efficacy of Metal Starvation for Treating Gonococcal Disease.

By Michael T. Kammerman, B.S.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2020

Major Director: Cynthia Nau Cornelissen, Ph.D.

Professor, Department of Microbiology and Immunology

Neisseria gonorrhoeae, the bacterial agent that is responsible for the human disease gonorrhea, has had a steady increase in the number of infections per year. In 2018 the WHO estimated over 87 million infections occurred world-wide, and the ...


The Quantified Elf, Umico Niwa Jan 2020

The Quantified Elf, Umico Niwa

Theses and Dissertations

The Quantified Elf is an ongoing collection of scientific, medical, archaeological articles and excerpts from my personal journal. It is a way by which I explore the various ways Western notions of personhood subsume human life into constructs of sexuality and gender, overlooking the various other modes of unbridled existence: plant, microbial. fungal, animal, celestial bodies. The speculative medical papers propose novel forms of body modification to combat gender dysphoria.


The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine Jan 2020

The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine

Theses and Dissertations

Patients with severe lung pathologies, such as Acute Respiratory Distress Syndrome (ARDS), often require mechanical ventilation as a clinical intervention; however, this procedure frequently exacerbates the original pulmonary issue and produces an exaggerated inflammatory response that potentially leads to sepsis, multisystem organ failure, and mortality. This acute lung injury (ALI) condition has been termed Ventilator-Induced Lung Injury (VILI). Alveolar overdistension, cyclic atelectasis, and biotrauma are the primary injury mechanisms in VILI that lead to the loss of alveolar barrier integrity and pulmonary inflammation. Stress and strains during mechanical ventilation are believed to initiate alveolar epithelial mechanotransduction signaling mechanisms that contribute ...


Non-Invasive Retrieval Of Prefabricated Zirconia Crowns With Er,Cr:Ysgg Laser From Primary And Permanent Teeth, Connor W. Mccall Dds Jan 2020

Non-Invasive Retrieval Of Prefabricated Zirconia Crowns With Er,Cr:Ysgg Laser From Primary And Permanent Teeth, Connor W. Mccall Dds

Theses and Dissertations

Purpose: Compromised tooth structure on permanent and deciduous teeth in the pediatric population is increasingly being restored with tooth-colored prefabricated zirconia crowns. These restorations may need to be removed or replaced with permanent crowns. The purpose of this in vitro study was to explore the use of an Er,Cr:YSGG laser for removal of prefabricated zirconia crowns cemented with RMGI as a non-invasive alternative to rotary instruments.

Methods: Thirteen permanent and 12 primary molars were prepared to dentin and prefabricated zirconia crowns were passively fitted and cemented with two resin modified glass ionomer cements. The irradiation parameters for ErCR ...