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Full-Text Articles in Medicine and Health Sciences

Adverse Childhood Experiences And Changing Levels Of Psychosocial Distress Scores Across Pregnancy In Kenyan Women, Pauline Samia, Shahirose Premji, Farideh Tavangar, Ilona S. Yim, Sikolia Wanyonyi, Mohamoud Merali, Wangira Musana, Geoffrey Omuse, Ntonghanwah Forcheh, Aliyah Dosani, Nicole Letourneau, The Maternal Infant Global Health Team (Might) Collaborators In Research May 2020

Adverse Childhood Experiences And Changing Levels Of Psychosocial Distress Scores Across Pregnancy In Kenyan Women, Pauline Samia, Shahirose Premji, Farideh Tavangar, Ilona S. Yim, Sikolia Wanyonyi, Mohamoud Merali, Wangira Musana, Geoffrey Omuse, Ntonghanwah Forcheh, Aliyah Dosani, Nicole Letourneau, The Maternal Infant Global Health Team (Might) Collaborators In Research

Paediatrics and Child Health, East Africa

Background: Adverse childhood experiences (ACEs) have been associated with deleterious effects on mental health in pregnancy.

Methods: The ACE International Questionnaire (ACE-IQ) was used to measure neglect, abuse, and household dysfunction. Longitudinal mixed effect modelling was used to test the effect of ACEs on pregnancy-related anxiety, depressive symptoms, and perceived stress at two time points (12–19 and 22–29 weeks) during pregnancy.

Results: A total of 215 women who were predominantly married (81%) and had attained tertiary education (96%) were enrolled. Total ACEs were significantly associated with depressive symptoms (r = 0.23, p < 0.05) and perceived stress (r = 0.18, p < 0.05). As depressive symptoms decreased, t (167) = −8.44, p < 0.001, perceived stress increased, t (167) = 4.60, p < 0.001, and pregnancy-related anxiety remained unchanged as pregnancy progressed. Contact sexual abuse (p < 0.01) and parental death or divorce (p = 0.01) were significantly associated with depression over time (p < 0.01). Total ACEs in this study were associated with depressive symptoms early but not late in pregnancy.

Conclusions: Higher total ACEs were positively ...


“Children Are A Blessing From God” – A Qualitative Study Exploring The Socio-Cultural Factors Influencing Contraceptive Use In Two Muslim Communities In Kenya, Batula Abdi, Jerry Okal, Gamal Serour, Marleen Temmerman Apr 2020

“Children Are A Blessing From God” – A Qualitative Study Exploring The Socio-Cultural Factors Influencing Contraceptive Use In Two Muslim Communities In Kenya, Batula Abdi, Jerry Okal, Gamal Serour, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Family planning (FP) is one of the high impact public health interventions with huge potential to enhance the health and wellbeing of women and children. Yet, despite the steady progress made towards expanding access to family planning, major disparities across different regions exist in Kenya. This study explored the socio cultural factors influencing FP use among two Muslim communities in Kenya.

Methods: A qualitative study involving Focus Group Discussions (FGDs) and In-depth Interviews (IDIs) was conducted (from July to October 2018) in two predominant Muslim communities of Lamu and Wajir counties. Open ended questions explore key thematic areas around ...


Religious Beliefs, Social Pressure, And Stigma: Rural Women’S Perceptions And Beliefs About Vasectomy In Pwani, Tanzania, Eunice Pallangyo, Agnes Msoka, Sharon Brownie, Eleanor Holroyd Mar 2020

Religious Beliefs, Social Pressure, And Stigma: Rural Women’S Perceptions And Beliefs About Vasectomy In Pwani, Tanzania, Eunice Pallangyo, Agnes Msoka, Sharon Brownie, Eleanor Holroyd

School of Nursing & Midwifery, East Africa

Despite being a reliable and cost effective family planning method, vasectomy remains underutilized in many low resource settings such as East Africa. We explored rural women’s perceptions and beliefs regarding barriers to vasectomy use in the low resource setting of Pwani, Tanzania. The qualitative study used in-depth semi-structured interviews to obtain data. Purposive sampling was used to recruit 20 married/cohabiting women with two or more children. Thematic analysis guided the data analysis, with qualitative data reporting informed by COREQ guidelines. Most participants were Muslim and had between two and six children. Most had completed primary-level education and were ...


Labrad : Vol 46, Issue 1 - March 2020, Aga Khan University Hospital, Karachi Mar 2020

Labrad : Vol 46, Issue 1 - March 2020, Aga Khan University Hospital, Karachi

LABRAD

  • Role of Immunofluorescence Studies in the Diagnosis of Autoimmune Disorders
  • Cystathionine Beta-Synthase Deficiency
  • Treatment of Factor VIII Inhibitor
  • Effective Internal Communication in Laboratories
  • Digital Breast Tomosynthesis
  • Overview of Common Myeloproliferative Neoplasms
  • Clinical Significance of free Androgen Index (FAI)
  • Radiology Quiz
  • The Best of the Past
  • Section Of Histopathology: Newer Horizons
  • A Webinar Series ‘Rare Links’
  • A Look into the Eye can Unleash Vital Diagnostic Pearls for 32 Rare Disorders
  • Lab & Rad Mesh up for the Early Recognition of Rare Disorders
  • Polaroid


Pharmacy Newsletter : March 2020, Pharmacy Department Mar 2020

Pharmacy Newsletter : March 2020, Pharmacy Department

Pharmacy Newsletter

Content:

  • Roles of Pharmacist during the COVID‐19 Pandemic
  • Drug Interaction Update
  • ToxTalk | Bleach Ingestion
  • COVID-19- Recommended Practice
  • Drug Induced Nutrient & Vitamin Deficiency


Evaluation Of Non-Invasive Continuous Physiological Monitoring Devices For Neonates In Nairobi, Kenya: A Research Protocol, Amy Sarah Ginsburg, Evangelyn Nkwopara, William Macharia, Roseline Ochieng, Mary Waiyego, Guohai Zhou, Roman Karasik, Shuai Xu, J Mark Ansermino Mar 2020

Evaluation Of Non-Invasive Continuous Physiological Monitoring Devices For Neonates In Nairobi, Kenya: A Research Protocol, Amy Sarah Ginsburg, Evangelyn Nkwopara, William Macharia, Roseline Ochieng, Mary Waiyego, Guohai Zhou, Roman Karasik, Shuai Xu, J Mark Ansermino

Paediatrics and Child Health, East Africa

Introduction: Continuous physiological monitoring devices are often not available for monitoring high-risk neonates in low-resource settings. Easy-to-use, non-invasive, multiparameter, continuous physiological monitoring devices could be instrumental in providing appropriate care and improving outcomes for high-risk neonates in these low-resource settings.

Methods and analysis: The purpose of this prospective, observational, facility-based evaluation is to provide evidence to establish whether two existing non-invasive, multiparameter, continuous physiological monitoring devices developed by device developers, EarlySense and Sibel, can accurately and reliably measure vital signs in neonates (when compared with verified reference devices). We will also assess the feasibility, usability and acceptability of these devices ...


Prediction Of Cognitive And Intellectual Competence In Kindergarten Schools Associated With General Measures Of Health: A Study On Children With Age Ranges Between 4 To 7 Years, Abeer Musaddiq, Yusra Saleem, Muhammad Bilal Siddiqui, Shamoon Noushad, Sadaf Ahmed Mar 2020

Prediction Of Cognitive And Intellectual Competence In Kindergarten Schools Associated With General Measures Of Health: A Study On Children With Age Ranges Between 4 To 7 Years, Abeer Musaddiq, Yusra Saleem, Muhammad Bilal Siddiqui, Shamoon Noushad, Sadaf Ahmed

Pakistan Journal of Neurological Sciences (PJNS)

BACKGROUND Stunting refers to the low “height-for-age” measurement. Literature suggests that it is associated with delayed or diminished physical development, cognition and intellectual abilities. OBJECTIVES: This study aimed to estimate the physical growth measures among children under 4 to 7 years of age and to determine its relationship with cognitive deficits & intellectual performances.


Neurological Involvement In Covid-19 Infections; Pathophysiology, Presentation And Outcome., Dureshahwar Kanwar, Muhammad Imran, Mohammad Wasay Mar 2020

Neurological Involvement In Covid-19 Infections; Pathophysiology, Presentation And Outcome., Dureshahwar Kanwar, Muhammad Imran, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Severe acute respiratory syndrome corona virus 2 (SARS CoV 2) seems to display an increasing affinity for the nervous system. The ongoing pandemic has made evident that diverse neurological manifestations may occur with COVID 19. Headache and dizziness remain the most common symptoms however stroke, seizures, encephalopathy, neuropathy and skeletal muscle injury may be seen. An increasing number of patients report initial anosmia and ageusia. Tendency for serious illness is believed to be in the elderly or people with a history of diabetes, high blood pressure and heart disease. Many patients on immunosuppressive therapies such as multiple sclerosis, myasthenia gravis ...


Narcolepsy :A Review Amongst Sleep Disorders., Muhammad Umer Ahmed, Manahil Jeoffrey, Omer Ahmed Mar 2020

Narcolepsy :A Review Amongst Sleep Disorders., Muhammad Umer Ahmed, Manahil Jeoffrey, Omer Ahmed

Pakistan Journal of Neurological Sciences (PJNS)

Narcolepsy is a sleep disorder known and studied about from time to time is a sleep disorder characterized by a combination of myriad of symptoms including excessive day time sleepiness with recurrent irresistible sleep attacks , hypnogogic hallucinations ,hypnopompic hallucinations ,sleep paralysis and cataplexy (sudden and bilateral loss of muscle tone.1 Narcolepsy may present it self long with cataplexy or without cataplexy. The pathogenesis behind narcolepsy is found to be due to degeneration of hypocretin/orexin secreting neurones in the central nervous system due to disorder of human leukocyte antigen DQB1*0602.Narcolepsy is a deblitating disorder which causes intense ...


Chikungunya Encephalitis: Usual Presentation At An Unusual Time. A Case Report, Muhammad Owais Hashmat, Dureshahwar Kanwar, Iffat Khanum Khanum Mar 2020

Chikungunya Encephalitis: Usual Presentation At An Unusual Time. A Case Report, Muhammad Owais Hashmat, Dureshahwar Kanwar, Iffat Khanum Khanum

Pakistan Journal of Neurological Sciences (PJNS)

CHIK is an arboviral infection caused by chikungunya virus transmitted by Aedes mosquito worldwide. It usually manifests as a self-limiting acute febrile illness with rash, body ache and severe polyarthralgia; in some patients, symptoms persist up to months or even years. Neurological manifestations are relatively uncommon. In recent years Pakistan and other South East Asian countries have been hit several times by its epidemics1. We report a case of a middle-aged male who presented in our hospital with acute febrile illness along with neurological manifestations. Extensive laboratory investigations were done and he was diagnosed with seropositive CHIKV. He was treated ...


Patterns Of Eeg(Electroencephalogram) Findings In Patients With Neurological Disorders, Saba Zaidi, Amsa Khan Mar 2020

Patterns Of Eeg(Electroencephalogram) Findings In Patients With Neurological Disorders, Saba Zaidi, Amsa Khan

Pakistan Journal of Neurological Sciences (PJNS)

OBJECTIVE: To study the patterns of EEG in patients with neurological disorders BACKGROUND: EEG is still relevant in the diagnosis and management of patients with seizure disorders and extends to other neurological conditions, however local data is limited


Myotonic Dystrophy In A Pakistani Family: A Case Series And Literature Review, Waleed Shahzad, Muhammad Hassan, Mazhar Badshah, Haris Majid Rajput, Zakir Jan, Tehmina Inayat Mar 2020

Myotonic Dystrophy In A Pakistani Family: A Case Series And Literature Review, Waleed Shahzad, Muhammad Hassan, Mazhar Badshah, Haris Majid Rajput, Zakir Jan, Tehmina Inayat

Pakistan Journal of Neurological Sciences (PJNS)

Myotonic dystrophy also known as (Steinert's disease) is a clinically and genetically heterogeneous multisystem disorder with a prevalence of 1 in 8000 in the general population. It is inherited as an autosomal dominant trait. It is characterized by myotonia, myopathy of voluntary and involuntary muscles, frontal baldness in men, cardiac conduction abnormalities, cataracts, intellectual deterioration and endocrinopathies. Affected men may have gonadal atrophy and infertility. On the other hand women are generally fertile. We report a case series of three individuals belonging to the same family presenting with characteristic features of myotonic dystrophy. The presentation of these cases depicts ...


Memory And Cognitive Flexibility In Physical Therapy Students Of Karachi, Sonya Arshad, Muhammad Faisal Qureshi, Syed Hasan Abbas Rizvi, Javeria Rizvi, Kanza Imtiaz, Kisa Hussain Rizvi, Khushbakht Ahmed, Khola Noman, Vishal Kumar Mar 2020

Memory And Cognitive Flexibility In Physical Therapy Students Of Karachi, Sonya Arshad, Muhammad Faisal Qureshi, Syed Hasan Abbas Rizvi, Javeria Rizvi, Kanza Imtiaz, Kisa Hussain Rizvi, Khushbakht Ahmed, Khola Noman, Vishal Kumar

Pakistan Journal of Neurological Sciences (PJNS)

Memory allows us to remember the skills that we have learnt and retrieve valuable information stored in the brain. Physical therapy is a multidimensional profession which demands efficient cognitive flexibility and decision-making skills with an excellent memory to help the therapist to multi-task.


Cutaneous Allodynia In Migraine, Dr. Ghulam Shabbir, Dr. Haris Majid Rajput, Dr. Zakir Jan Mar 2020

Cutaneous Allodynia In Migraine, Dr. Ghulam Shabbir, Dr. Haris Majid Rajput, Dr. Zakir Jan

Pakistan Journal of Neurological Sciences (PJNS)

OBJECTIVE: Objective of this study is to find out the presence and severity of cutaneous allodynia in migraine sufferers. BACKGROUND: Cutaneous allodynia is the perception of pain in response to non noxious stimuli. It occurs due to repeated stimulations that lead to sensitization and abnormal skin response. MATERIALS AND METHODS: It was a descriptive case study and conducted at Neurology department Pakistan Institute of Medical Sciences from June 2017 to May 2018. All patients of both genders above age 13 years of age with migraine diagnosed as having “Migraine without aura” or “Migraine with aura” according to the International Headache ...


Distance Learning For Neurology: Experiences From Mini-Fellowship In Movement Disorders., Danish Bhatti, John Bertoni Mar 2020

Distance Learning For Neurology: Experiences From Mini-Fellowship In Movement Disorders., Danish Bhatti, John Bertoni

Pakistan Journal of Neurological Sciences (PJNS)

Sub-speciality training in neurology is not available in Pakistan given lack of trained supervising faculty. Developing trained supervisors by sending faculty abroad for formal fellowships is too slow, resource intense and subject to attrition or brain-drain. Web-based learning methods have been used effectively in training in medicine. Meta-analysis of 201 eligible studies showed large positive effects of E-learning in health professionals compared with no interventions1. There are highly qualified academic neurologists available in developed countries of Pakistani origin providing opportunity to bridge the gap and transfer skills.


Covid-19 Infection; Loss Of Taste, Smell, And Neurogenic Respiratory Failure, Abdul Mannan Baig, Mohammad Wasay Mar 2020

Covid-19 Infection; Loss Of Taste, Smell, And Neurogenic Respiratory Failure, Abdul Mannan Baig, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Neurological Signs and Symptoms in COVID-19: Like the rest of the world, Pakistan is been gripped by unprecedented and complex burden of COVID-19. While the diseases got upgraded to a pandemic, the preparedness of even the first world countries to combat COVID-19 is distressing, as there seems to be a lack of clear strategy to tackle the disease spread and treatment.


Factors Predicting Need For Post-Operative Ventilation After Microsurgical Clipping Of Cerebral Aneurysms – A Multivariate Analysis, Usman Siddiqui, Muhammad Faheem Khan, Saad Bin Anis, Bushra Ahmad, Muhammad Shahzad Shamim, Rida Mitha, Fouzia Anis Khan, Erfan Hussain Mar 2020

Factors Predicting Need For Post-Operative Ventilation After Microsurgical Clipping Of Cerebral Aneurysms – A Multivariate Analysis, Usman Siddiqui, Muhammad Faheem Khan, Saad Bin Anis, Bushra Ahmad, Muhammad Shahzad Shamim, Rida Mitha, Fouzia Anis Khan, Erfan Hussain

Pakistan Journal of Neurological Sciences (PJNS)

Patients with aneurysmal Subarachnoid Hemorrhage (aSAH) frequently require Intensive Care Unit (ICU) beds, pre-operatively and more often, post-operatively due to the need for ventilatory support and specialized monitoring. We aimed to evaluate the frequency of post-operative ventilatory requirement in patients with aSAH and identify the possible predictive factors that might influence the need of post-operative ventilation in these patients. METHODS: We retrospectively identified a five-year data of all patients with aSAH who underwent surgical clipping using a structured proforma. Aneurysm was confirmed by Digital Subtraction Angiography (DSA) or Computerized Tomographic Angiography (CTA).


Mainstreaming Nutrition Services: Stabilization Centers And Outpatient Therapeutic Program Centers, Ashar Muhammad Malik Mar 2020

Mainstreaming Nutrition Services: Stabilization Centers And Outpatient Therapeutic Program Centers, Ashar Muhammad Malik

Community Health Sciences

No abstract provided.


Factors Associated With First Antenatal Care Booking Among Pregnant Women At A Reproductive Health Clinic In Tanzania: A Cross Sectional Study, Lucy Kisaka, Sebalda Leshabari Feb 2020

Factors Associated With First Antenatal Care Booking Among Pregnant Women At A Reproductive Health Clinic In Tanzania: A Cross Sectional Study, Lucy Kisaka, Sebalda Leshabari

School of Nursing & Midwifery, East Africa

Background: Antenatal care (ANC) is a key basic intervention targeting maternal and perinatal morbidity and mortality. The World Health Organization (WHO) recommends the first ANC booking before 12 weeks of gestation. This enhances positive maternal and fetal outcomes through early detection of complications, prompt treatment, referral, and management of expected physiological changes. Despite high ANC coverage (98%), free contacts, and easy accessibility, little is known why few (24%) pregnant women in Tanzania book their first ANC-visit early. This study aimed to identify factors associated with first ANC booking among pregnant women in a Tanzanian reproductive health clinic.

Methods: Systematic random ...


Hiv Pre‐Exposure Prophylaxis For Female Sex Workers: Ensuring Women’S Family Planning Needs Are Not Left Behind, Anna L. Bowring, Frances H Ampt, Sheree Schwartz, Mark A. Stoove, Stanley Luchters, Stefan Baral, Margaret Hellard Feb 2020

Hiv Pre‐Exposure Prophylaxis For Female Sex Workers: Ensuring Women’S Family Planning Needs Are Not Left Behind, Anna L. Bowring, Frances H Ampt, Sheree Schwartz, Mark A. Stoove, Stanley Luchters, Stefan Baral, Margaret Hellard

Population Health, East Africa

Introduction: Female sex workers (FSWs) experience overlapping burdens of HIV, sexually transmitted infections and unin- tended pregnancy. Pre-exposure prophylaxis (PrEP) is highly efficacious for HIV prevention. It represents a promising strategy to reduce HIV acquisition risks among FSWs specifically given complex social and structural factors that challenge consistent condom use. However, the potential impact on unintended pregnancy has garnered little attention. We discuss the potential concerns and opportunities for PrEP to positively or negatively impact the sexual and reproductive health and rights (SRHR) of FSWs.

Discussion: FSWs have high unmet need for effective contraception and unintended pregnancy is common in ...


Ethnic Disparity And Exposure To Supplements Rather Than Adverse Childhood Experiences Linked To Preterm Birth In Pakistani Women, Kiran Shaikh, Shahirose Sadrudin Premjib, Sharifa Bashir Lalani, Ntonghanwah Forcheh, Aliyah Dosanic, Ilona S. Yim, Pauline Samia, Christopher Naugler, Nicole Letourneau, The Maternal Infant Global Health Team (Might) Collaborators In Research Feb 2020

Ethnic Disparity And Exposure To Supplements Rather Than Adverse Childhood Experiences Linked To Preterm Birth In Pakistani Women, Kiran Shaikh, Shahirose Sadrudin Premjib, Sharifa Bashir Lalani, Ntonghanwah Forcheh, Aliyah Dosanic, Ilona S. Yim, Pauline Samia, Christopher Naugler, Nicole Letourneau, The Maternal Infant Global Health Team (Might) Collaborators In Research

Paediatrics and Child Health, East Africa

Background: Adverse childhood experiences (ACEs) are associated with prenatal mental health and negative pregnancy outcomes in high income countries, but whether the same association exists in Pakistan, a low- to middle-income (LMI) country, remains unclear.

Methods: Secondary data analyses of a prospective longitudinal cohort study examining biopsychosocial measures of 300 pregnant women at four sites in Karachi, Pakistan. A predictive multiple logistic regression model for preterm birth (PTB; i.e., <37 weeks’ gestation) was developed from variables significantly (P < 0.05) or marginally (P < 0.10) associated with PTB in the bivariate analyses.

Results: Of the 300 women, 263 (88%) returned for delivery and were included in the current analyses. The PTB rate was 11.1%. We found no association between ACE and ...


Point-Of-Care Hpv Molecular Diagnostics For A Test-And-Treat Model In High-Risk Hiv Populations, Shahin Sayed, Michael Chung, Marleen Temmerman Feb 2020

Point-Of-Care Hpv Molecular Diagnostics For A Test-And-Treat Model In High-Risk Hiv Populations, Shahin Sayed, Michael Chung, Marleen Temmerman

Pathology, East Africa

Strategies for cervical cancer prevention and control in low-income and middle-income countries (LMICs) require concerted efforts to improve screening and access to treatment, especially in high-risk HIV populations. LMICs bear the largest burden of HIV infection, human papillomavirus (HPV) infection is common among HIV-infected women, risk of cervical cancer is increased in women with HIV/AIDS, and HIV clinics provide opportunities to screen and treat for cervical cancer in this population.


Deliver On Your Own: Disrespectful Maternity Care In Rural Kenya, Adelaide Lusambili, Violet Naanyu, Terrance J. Wade, Lindsay Mossman, Michaela Mantel, Rachel Pell, Angela Ng'etich, Kennedy Mulama, Lucy Nyaga, Jerim Obure, Marleen Temmerman Jan 2020

Deliver On Your Own: Disrespectful Maternity Care In Rural Kenya, Adelaide Lusambili, Violet Naanyu, Terrance J. Wade, Lindsay Mossman, Michaela Mantel, Rachel Pell, Angela Ng'etich, Kennedy Mulama, Lucy Nyaga, Jerim Obure, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Under the Free Maternity Policy (FMP), Kenya has witnessed an increase in health facility deliveries rather than home deliveries with Traditional Birth Attendants (TBA) resulting in improved maternal and neonatal outcomes. Despite these gains, maternal and infant mortality and morbidity rates in Kenya remain unacceptably high indicating that more needs to be done.

Aim: Using data from the Access to Quality Care through Extending and Strengthening Health Systems (AQCESS) project’s qualitative gender assessment, this paper examines women’s experience of disrespectful care during pregnancy, labour, and delivery. The goal is to promote an improved understanding of the actual ...


Exploring The Experiences Of The Older Adults Who Are Brought To Live In Shelter Homes In Karachi, Pakistan: A Qualitative Study, Laila Akber Cassum, Keith Cash, Waris Qidwai Dr, Samina Vertejee Jan 2020

Exploring The Experiences Of The Older Adults Who Are Brought To Live In Shelter Homes In Karachi, Pakistan: A Qualitative Study, Laila Akber Cassum, Keith Cash, Waris Qidwai Dr, Samina Vertejee

School of Nursing & Midwifery

Background: The traditional joint family system in a culturally diverse Pakistani society shows great respect and care for older population by the families and their generations. However, in the recent years the phenomenon of population ageing in Pakistan is rapidly increasing due to demographic shift influencing life expectancy, along with changes in socio-cultural values. This transition has resulted in institutionalization of the elderly as an emerging shelter alternative. The aim of this study was to explore the experiences of the elderly people and to identify the reason which compelled them to reside in these shelter homes.
Method: A ...


Cime Newsletter : January 2020, Cime Jan 2020

Cime Newsletter : January 2020, Cime

CIME Newsletter

-Bye 2019, Hi 2020!
-Let’s start 2020 with some reflections on 2019
-News: December 2019 – January 2020
-CIME becomes South Asia’s first to receive SSH accreditation
-RE-ignite the SEARCH 2.0: Research Symposium
-Code Orange Activated @ CIME!
-Management of Common Dermatological Disorders
-Clinical Simulation Educators Programme
-Champions’ Conference 2.0
-AdAsia 2019


Clinical Characteristics Of Children With Epilepsy Managed At An Urban Hospital In Africa: A Retrospective Study, Pauline Samia, Arwen Barr, Subira B. Levi, Kirsten A. Donald, Jo M. Wilmshurst, Charles R. Newton Dec 2019

Clinical Characteristics Of Children With Epilepsy Managed At An Urban Hospital In Africa: A Retrospective Study, Pauline Samia, Arwen Barr, Subira B. Levi, Kirsten A. Donald, Jo M. Wilmshurst, Charles R. Newton

Paediatrics and Child Health, East Africa

Background: Most children with epilepsy reside in resource-limited regions such as sub-Saharan Africa, where the majority of studies have been conducted in rural areas with limited investigations. Medical records from children with epilepsy seen at an urban hospital in Kenya were examined to provide a comprehensive description of epilepsy in children from this hospital.
Methods: A retrospective observational study was conducted which involved reviewing medical records of 426 epilepsy patients (260 males and 166 females) aged 0 - 18 years, seen in Nairobi, Kenya between February 2011 and December 2014. Results: The most frequent age at presentation; documented in 29% was ...


Is It T3 Thyrotoxicosis? A Case Of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading To A Diagnosis Of Multiple Myeloma, Nanik Ram, Saira Furqan, Sibtain Ahmed Dec 2019

Is It T3 Thyrotoxicosis? A Case Of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading To A Diagnosis Of Multiple Myeloma, Nanik Ram, Saira Furqan, Sibtain Ahmed

Section of Diabetes, Endocrinology and Metabolism

We are presenting a case of falsely elevated T3 levels in a patient due to interference from monoclonal immunoglobulins. A 56-year-old, clinically euthyroid man referred to the endocrinology clinic of the Aga Khan university, Karachi Pakistan, for possible T3 thyrotoxicosis after thyroid function tests revealed total T3 >12.32 nmol/L (reference range 0.6-2.79), normal TSH, and total T4 level. There was a mismatch in clinical and laboratory parameters and preliminary laboratory results were suggestive of thyroid binding globulin abnormalities. Further evaluation in this context unmasked multiple myeloma. The presence of monoclonal immunoglobulins can lead to assay interference ...


Delivery Mode For Prolonged, Obstructed Labour Resulting In Obstetric Fistula: A Retrospective Review Of 4396 Women In East And Central Africa, C. J. Ngongo, T. J. Raassen, L. Lombard, J Van Roosmalen, S. Weyers, Marleen Temmerman Dec 2019

Delivery Mode For Prolonged, Obstructed Labour Resulting In Obstetric Fistula: A Retrospective Review Of 4396 Women In East And Central Africa, C. J. Ngongo, T. J. Raassen, L. Lombard, J Van Roosmalen, S. Weyers, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Objective: To evaluate the mode of delivery and stillbirth rates over time among women with obstetric fistula.

Design: Retrospective record review.

Setting: Tanzania, Uganda, Kenya, Malawi, Rwanda, Somalia, South Sudan, Zambia and Ethiopia.

Population: A total of 4396 women presenting with obstetric fistulas for repair who delivered previously in facilities between 1990 and 2014.

Methods: Retrospective review of trends and associations between mode of delivery and stillbirth, focusing on caesarean section (CS), assisted vaginal deliveries and spontaneous vaginal deliveries.

Main outcome measures: Mode of delivery, stillbirth.

Results: Out of 4396 women with fistula, 3695 (84.1%) delivered a stillborn baby ...


Fingolimod Plays Role In Attenuation Of Myocardial Injury Related To Experimental Model Of Cardiac Arrest And Extracorporeal Life Support Resuscitation, Naseer Ahmed, Abid Laghari, Bashar Albkhoor, Sobia Tabassum, Sultan Ayoub Meo, Nazeer Muhammad, Daniele Linardi, Abeer A. Al-Masri, Guido Fumagalli, Giovanni Battista Luciani, Giuseppe Faggian, Alessio Rungatscher Dec 2019

Fingolimod Plays Role In Attenuation Of Myocardial Injury Related To Experimental Model Of Cardiac Arrest And Extracorporeal Life Support Resuscitation, Naseer Ahmed, Abid Laghari, Bashar Albkhoor, Sobia Tabassum, Sultan Ayoub Meo, Nazeer Muhammad, Daniele Linardi, Abeer A. Al-Masri, Guido Fumagalli, Giovanni Battista Luciani, Giuseppe Faggian, Alessio Rungatscher

Department of Biological & Biomedical Sciences

Background: Sudden cardiac arrest is a major global health concern, and survival of patients with ischemia-reperfusion injury is a leading cause of myocardial dysfunction. The mechanism of this phenomenon is not well understood because of the complex pathophysiological nature of the disease. Aim of the study was to investigate the cardioprotective role of fingolimod in an in vivo model of cardiac arrest and resuscitation.
Methods: In this study, an in vivo rat model of cardiac arrest using extracorporeal membrane oxygenation resuscitation monitored by invasive hemodynamic measurement was developed. At the beginning of extracorporeal life support (ECLS), animals were randomly treated ...


Time To Clarify State Obligations And Accountability On Ncds With Human Rights Instruments, Kent Buse, Wafa Aftab, Sadika Akhter, Linh Bui Phuong, Haroun Chamli, Minakshi Dahal, Sarah Hawke, Nousheen Pradhan Dec 2019

Time To Clarify State Obligations And Accountability On Ncds With Human Rights Instruments, Kent Buse, Wafa Aftab, Sadika Akhter, Linh Bui Phuong, Haroun Chamli, Minakshi Dahal, Sarah Hawke, Nousheen Pradhan

Community Health Sciences

No abstract provided.