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2001

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Articles 1 - 30 of 1326

Full-Text Articles in Medicine and Health Sciences

Placenta Detachment: Unexpected High Concentrations Of 5-Hydroxytryptamine (Serotonin) In Fetal Blood And Its Mitogenic Effect On Placental Cells In Bovine, Kellie Fecteau, Hugo Eiler Jun 2014

Placenta Detachment: Unexpected High Concentrations Of 5-Hydroxytryptamine (Serotonin) In Fetal Blood And Its Mitogenic Effect On Placental Cells In Bovine, Kellie Fecteau, Hugo Eiler

Kellie Fecteau

The purpose of this study was twofold: (1) to determine whether there is a profile of 5-hydroxytryptamine (5-HT, serotonin) concentrations in fetal bovine blood and tissues during pregnancy, parturition and the early neonatal period and (2) to determine whether 5-HT has a 'mitogenic' effect on cultured placentome cells in bovine. Results revealed a 5-HT concentration profile in fetal blood. Overall concentrations of 5-HT in fetal blood were 6.6 times (P< 0.001) that of adult cows and 2.8 times (P< 0.001) that of blood collected during caesarean section (from umbilical veins) and from 18-72 h old calves ...


Radiation And Intralesional Chemotherapy For A Fibrosarcoma In A Boa Constrictor, Boa Constrictor Ortoni, J Langan, William Adams, S Patton, K Lindermann, Juergen Schumacher Apr 2013

Radiation And Intralesional Chemotherapy For A Fibrosarcoma In A Boa Constrictor, Boa Constrictor Ortoni, J Langan, William Adams, S Patton, K Lindermann, Juergen Schumacher

Juergen P. Schumacher

No abstract provided.


Anatomy Of Structures Associated With The Lower Respiratory Tract Of The Gray, Short-Tailed Opossum (Monodelphis Domestica), L Cope, Robert Henry, Robert Reed Jul 2012

Anatomy Of Structures Associated With The Lower Respiratory Tract Of The Gray, Short-Tailed Opossum (Monodelphis Domestica), L Cope, Robert Henry, Robert Reed

Robert B. Reed, Jr., DVM, Ph.D.

No abstract provided.


Deletions In The 7a Orf Of Feline Coronavirus Associated With An Epidemic Of Feline Infectious Peritonitis, Melissa Kennedy, N Boedeker, P Gibbs, Stephen Kania Mar 2012

Deletions In The 7a Orf Of Feline Coronavirus Associated With An Epidemic Of Feline Infectious Peritonitis, Melissa Kennedy, N Boedeker, P Gibbs, Stephen Kania

Stephen A Kania

A population of Persian cats experienced an epidemic of feline infectious peritonitis (FIP) over 2 years. Twelve cases of FIP occurred in litters born during this period. Cats contracting FIP were all genetically related through the sire. Feline coronavirus (FCoV) genomic RNA was detected consistently in this study in biologic samples from adult cats, kittens suffering from FIP, and their siblings. Analysis of viral 7a/7b open reading frame (ORFs) were analyzed and revealed two distinct virus variants circulating in the population, one with an intact 7a ORF and one with two major deletions in the 7a ORF. The 7b ...


Detection Of Feline Coronavirus Infection In Captive Cheetahs (Acinonyx Jubatus) By Polymerase Chain Reaction, Melissa Kennedy, S Citino, T Dolorico, A Mcnabb, A Moffat, Stephen Kania Mar 2012

Detection Of Feline Coronavirus Infection In Captive Cheetahs (Acinonyx Jubatus) By Polymerase Chain Reaction, Melissa Kennedy, S Citino, T Dolorico, A Mcnabb, A Moffat, Stephen Kania

Stephen A Kania

Feline coronavirus genetic elements were detected by polymerase chain reaction from blood, fecal samples, and effusive fluid collected from 33 cheetahs in the U.S.A. Feline coronavirus-specific serum antibodies were also measured by indirect immunofluorescence. Ten cheetahs were positive for viral shedding by polymerase chain reaction, whereas 13 were seropositive by immunofluorescence. Results of serology did not consistently correlate with shedding of virus, and the capture antigen used for detection of feline coronavirus-specific antibodies had a significant impact on results. Testing of samples from one population over a 1-yr period indicated chronic infection in some animals. These relatively healthy ...


Diagnosis And Management Of A Patent Urachus In A White Rhinoceros Calf (Ceratotherium Simum Simum), J Langan, Edward Ramsay, Juergen Schumacher, T Chism, Henry Adair, Iii Aug 2011

Diagnosis And Management Of A Patent Urachus In A White Rhinoceros Calf (Ceratotherium Simum Simum), J Langan, Edward Ramsay, Juergen Schumacher, T Chism, Henry Adair, Iii

Juergen P. Schumacher

A 10-day-old female southern white rhinoceros calf (Ceratotherium simum simum) was diagnosed with a patent urachus after urine was observed dribbling from the umbilicus. After being separated from its mother, the animal was sedated with i.m. butorphanol and anesthetized with isoflurane in oxygen for surgical correction of the patent urachus. Mild postoperative complications involved seroma formation and partial skin incision dehiscence, which necessitated three follow-up immobilizations for reevaluation and treatment of the surgical site. Histopathology did not reveal an infectious etiology as the cause for the complications or for the patent urachus. The etiology of the patent urachus in ...


Epidemiology Of Feline Infectious Peritonitis Among Cats Examined At Veterinary Medical Teaching Hospitals, Barton Rohrbach, Alfred Legendre, C Baldwin, D Lein, W Reed, R Wilson Dec 2010

Epidemiology Of Feline Infectious Peritonitis Among Cats Examined At Veterinary Medical Teaching Hospitals, Barton Rohrbach, Alfred Legendre, C Baldwin, D Lein, W Reed, R Wilson

Alfred M Legendre DVM, MS, DACVIM

To determine proportions of cats in which feline infectious peritonitis (FIP) was diagnosed on an annual, monthly, and regional basis and identify unique characteristics of cats with FIP, Records of all feline accessions to veterinary medical teaching hospitals (VMTH) recorded in the Veterinary Medical Data Base between January 1986 and December 1995 and of all feline accessions for necropsy or histologic examination at 4 veterinary diagnostic laboratories were studied. Proportions of total and new feline accessions for which a diagnosis of FIP was recorded were calculated. To identify characteristics of cats with FIP, cats with FIP were compared with the ...


Systems Analysis Projects In Advanced Nursing Practice Education, Barfield John, Debra Smith, Maribeth Smith Dec 2001

Systems Analysis Projects In Advanced Nursing Practice Education, Barfield John, Debra Smith, Maribeth Smith

The Corinthian

The purpose of the presentation is to stimulate discussion among nursing educators regarding integration of an educational strategy which can enhance the ability of graduate students to analyze clinical and administrative problems.


Will Theaters Receive Two Thumbs Up From Individuals With Disabilities?, Joseph H. Huber Dec 2001

Will Theaters Receive Two Thumbs Up From Individuals With Disabilities?, Joseph H. Huber

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

No abstract provided.


Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin Dec 2001

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 ...


Going Global The Fastest Way To The Top, Rick Burton Dec 2001

Going Global The Fastest Way To The Top, Rick Burton

Sport Management

No abstract provided.


Estrogen And Antiestrogen Actions On Human Prostate Cancer: A Dissertation, Kin-Mang Lau Dec 2001

Estrogen And Antiestrogen Actions On Human Prostate Cancer: A Dissertation, Kin-Mang Lau

GSBS Dissertations and Theses

Prostate cancer increases its incidence with age after men in their fifth decade as the ratio of estrogen to androgen rises. Epidemiological studies indicated that high levels of estrogens are associated with the high-risk ethnic groups for prostate cancer. Therefore, estrogens may be involved in prostatic carcinogenesis. It is widely believed that the actions of estrogens are mediated by estrogen receptors. However, expression of estrogen receptor in normal prostate and lesions of the gland was controversial. With the recent discovery of second estrogen receptor (ER-β), this issue became more complicated and it needs to be readdressed. In addition, the biological ...


Effect Of Seeing Tobacco Use In Films On Trying Smoking Among Adolescents: Cross Sectional Study, James D. Sargent, Michael L. Beach, Madeline A. Dalton, Leila A. Mott, Jennifer J. Tickle, M. Bridget Ahrens, Todd F. Heatherton Dec 2001

Effect Of Seeing Tobacco Use In Films On Trying Smoking Among Adolescents: Cross Sectional Study, James D. Sargent, Michael L. Beach, Madeline A. Dalton, Leila A. Mott, Jennifer J. Tickle, M. Bridget Ahrens, Todd F. Heatherton

Open Dartmouth: Faculty Open Access Articles

Objective: To test the hypothesis that greater exposure to smoking in films is associated with trying smoking among adolescents.


Nipple Aspirate Cytology And Pathologic Parameters Predict Residual Cancer And Nodal Involvement After Excisional Breast Biopsy., E R Sauter, H Ehya, A Mammen, G Klein Dec 2001

Nipple Aspirate Cytology And Pathologic Parameters Predict Residual Cancer And Nodal Involvement After Excisional Breast Biopsy., E R Sauter, H Ehya, A Mammen, G Klein

Department of Surgery Faculty Papers

We previously demonstrated that abnormal nipple aspirate fluid (NAF) cytology predicted residual breast cancer (RC) and tumour size after excisional biopsy (EB), although normal NAF cytology did not exclude RC. Tumour size correlates with the risk of lymph node (LN) metastases. LN metastases provide prognostic information allowing medical and radiation oncologists to determine the need for adjuvant therapy. We hypothesized that pathologic factors known after EB, combined with NAF cytology, would predict with a high degree of accuracy the presence of RC and LN spread. NAF cytology and pathologic parameters: tumour distance from biopsy margins, multifocal and multicentric disease, sub-type ...


Regulation Of Nuclear Hormone Receptors By Corepressors And Coactivators: A Dissertation, Xiaoyang Wu Dec 2001

Regulation Of Nuclear Hormone Receptors By Corepressors And Coactivators: A Dissertation, Xiaoyang Wu

GSBS Dissertations and Theses

Nuclear hormone receptors (NHR) constitute a superfamily of ligand inducible transcriptional activators that enable an organism to regulate development and homeostasis through switching on or off target genes in response to stimuli reflecting changes in environment as well as endocrine. NHRs include classical steroid hormone receptors (GR, AR, ER and MR) and retinoid, thyroid hormone receptors. One long-term goal of our lab is to understand the molecular mechanisms through which the transcriptional activity of NHRs is regulated.

Extensive studies in the past few years have revealed that in addition to the dependence on ligand availability, the transcriptional activity of NHRs ...


Neonatal Pain Management: The Evaluation Of Two Methods On Educating Neonatal Nurses, Jacqueline Jupin Manzi Dec 2001

Neonatal Pain Management: The Evaluation Of Two Methods On Educating Neonatal Nurses, Jacqueline Jupin Manzi

Seton Hall University Dissertations and Theses (ETDs)

.


Educating The Next Generation Of Physicians About Stroke: Incorporating Stroke Prevention Into The Medical School Curriculum, Susan Billings-Gagliardi, Nancy M. Fontneau, Merrill K. Wolf, Susan V. Barrett, George J. Hademenos, Kathleen M. Mazor Dec 2001

Educating The Next Generation Of Physicians About Stroke: Incorporating Stroke Prevention Into The Medical School Curriculum, Susan Billings-Gagliardi, Nancy M. Fontneau, Merrill K. Wolf, Susan V. Barrett, George J. Hademenos, Kathleen M. Mazor

Open Access Articles

BACKGROUND AND PURPOSE: In response to the need to educate physicians about stroke, we have implemented an educational program on stroke prevention for undergraduate medical students within the first-year neuroscience course. This study investigated whether first-year students learned and retained key information about stroke, and used students' feedback both to identify effective curricular components and to explore their attitudes regarding stroke prevention.

METHODS: Stroke knowledge and self-assessed confidence in that knowledge before, immediately after, and 8 months after participation in the stroke curriculum were analyzed and compared for 3 classes, using paired t tests and repeated-measures ANOVA. Student feedback about ...


Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky Dec 2001

Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Enhanced formation of reactive oxygen species (ROS), superoxide (O2*-), and hydrogen peroxide (H2O2) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms underlying activation of the apoptotic machinery by ROS. Exposure of permeabilized HepG2 cells to O2*- elicited rapid and massive cytochrome c release (CCR), whereas H2O2 failed to induce any release. Both O2*- and H2O2 promoted activation of the mitochondrial permeability transition pore by Ca2+, but Ca2+-dependent pore opening was not required for O2*--induced CCR. Furthermore, O2*- alone evoked CCR without damage of the inner mitochondrial membrane barrier, as mitochondrial ...


Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo Dec 2001

Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo

Faculty Publications, Department of Psychology

Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then ...


A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting Dec 2001

A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting

Open Dartmouth: Faculty Open Access Articles

Localization of ion channels and transporters to the correct membrane of polarized epithelia is important for vectorial ion movement. Prior studies have shown that the cytoplasmic carboxyl terminus of the cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the apical localization of this protein. Here we show that the C-terminal tail alone, or when fused to the green fluorescent protein (GFP), can localize to the apical plasma membrane, despite the absence of transmembrane domains. Co-expression of the C terminus with full-length CFTR results in redistribution of CFTR from apical to basolateral membranes, indicating that both proteins interact with the ...


Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen Dec 2001

Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen

Faculty Publications, Department of Psychology

Presumably, anger is a common experience of parenting. Although practitioners and researchers recognize the role of anger in various parenting situations, objective and standardized measures of parental anger have been notably lacking in the field. This study examined the Parental Anger Inventory (PAI), a measure developed specifically to assess parental anger in response to child misbehavior. A diverse sample of 98 parents participated in the study, including (a) physically abusive or neglectful parents, or both, n = 44; (b) nonmaltreating clinic parents seeking assistance for child behavior problems, n = 24; and (c) nonmaltreating, non–help-seeking community parents, n = 30. Results support ...


Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton Dec 2001

Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton

Open Dartmouth: Faculty Open Access Articles

We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated protein by using mass spectrometry. Most of these proteins are known spindle-associated components with essential functional roles in spindle organization. We generated antibodies against a protein identified in this collection and refer to it as astrin because of its association with astral microtubule arrays assembled in vitro. Astrin is approximately 134 kDa, and except for a large predicted coiled-coil domain in its C-terminal region it lacks any known functional motifs. Astrin associates with spindle microtubules as early as prophase where it concentrates at ...


Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen Dec 2001

Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen

Theses and Dissertations

Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed a systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens and ventral midbrain) across the BXD RI panel, a highly diverse family of isogenic mouse strains before and after treatment with ethanol. Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with ...


Behavioral Changes In Adult C57bl/6j Mice Following Prenatal Exposure To Ethanol., Kevin Wade Nunley Dec 2001

Behavioral Changes In Adult C57bl/6j Mice Following Prenatal Exposure To Ethanol., Kevin Wade Nunley

Electronic Theses and Dissertations

Fetal Alcohol Syndrome (FAS) labels children with physical, mental and behavioral deficits exposed to alcohol in utero. Current research indicates that timing of alcohol exposure of the embryo/fetus is a critical determinant of the behavioral deficits associated with FAS. This study represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment had been affected. Significant differences due to treatment and sex were ...


Molecular Studies Involving The Rev Protein Of Caprine Arthritis Encephalitis Virus And Visna Virus., Bridget Michele Graves Dec 2001

Molecular Studies Involving The Rev Protein Of Caprine Arthritis Encephalitis Virus And Visna Virus., Bridget Michele Graves

Electronic Theses and Dissertations

Caprine Arthirtis Encephalitis Virus (CAEV) and Visna Virus are two viruses of the lentivirus family. They encode three structural genes (gag, pol, and env) and two regulatory genes (rev and tat). The Rev protein regulates Gag, Pol and Env expression by transporting their mRNAs to the cytoplasm by binding to the RRE (Rev Response Element) found on their mRNAs. Previous studies have indicated that Rev may be toxic to transfected cells, overexpression of exogenous RREs or a better binding RRE can inhibit Rev activity and Rev-C (CAEV Rev) can trans-activate RRE-V (Visna Virus RRE). To test these possibilities FACS ...


Mapping Of Cortical Motor Reorganization In Spinal Cord Injury, Leonid Rozhkov Dec 2001

Mapping Of Cortical Motor Reorganization In Spinal Cord Injury, Leonid Rozhkov

Theses and Dissertations (ETD)

The annual incidence of spinal cord injury (SCI), not including those who die at the scene of the accident, is approximately 10,000 new cases in the United States. SCI, in its best outcome, may partially and temporarily disconnect the spinal cord from the brain. Some neuronal pathways remain intact in most S CI individuals, whose recovery depends on the utilization of the surviving connections. There is a change in the control of voluntary movements of the extremities by the cerebral cortex of the brain following spinal cord injury.

The technology of high-resolution EEG co-registered with MRI was applied to ...


Serum-Deprivation: A Model For Lens Cell Differentaition, Marcia Ong B.S. Dec 2001

Serum-Deprivation: A Model For Lens Cell Differentaition, Marcia Ong B.S.

Theses and Dissertations

Ong, Marcia., Serum-Deprivation: A Model for Lens Cell Differentiation. Master of Science (Biomedical Sciences), December, 2001, 154 pp., 2 tables, 36 illustrations, bibliography, 91 titles. The purpose of thisi project was to develop an in vitro cell culture system in which mammalian lens epithelial cells differentiate into lens fiber cells. METHODS. Primary cultures were grown from lens epithelium explants obtained from bovine lenses and propagated in Minimum Essential Medium containing 10% calf serum. Subsequently, cell cultures were maintained in MEM supplemented with either 4%, 3% or 1% calf serum and left undisturbed for 21 days. Immunofluorescence experiments and Western Blot ...


Texas D.O. Volume 58, Number 11, Texas Osteopathic Medical Association Dec 2001

Texas D.O. Volume 58, Number 11, Texas Osteopathic Medical Association

Texas Osteopathic Physicians Journal

No abstract provided.


Patterns Of Primary Surgical Procedures Among Men Admitted To Texas Hospitals With A Diagnosis Of Prostate Cancer, Rosemary Galdiano B.S.N. Dec 2001

Patterns Of Primary Surgical Procedures Among Men Admitted To Texas Hospitals With A Diagnosis Of Prostate Cancer, Rosemary Galdiano B.S.N.

Theses and Dissertations

Galdiano, Rosemary, Patterns of primary surgical procedures among men admitted to Texas hospitals with a diagnosis of prostate cancer. Master of Public Health (Epidemiology), December 2001, 28 pp., 3 tables, 4 illustrations, references, 21 titles. Data for the Texas Health Care Information Council was analyzed to identify the patterns of surgical procedures among men admitted to 114 Texas hospitals with a diagnosis of prostate cancer in 1999; and to determine whether these patterns varied by race and age. In all, 4,608 cases were compared for differences between age, race and type of surgical procedure using Pearson’s chi-square test ...


Changing Incidence Of Oral And Maxillofacial Tumours In East Java, Indonesia, 1987-1992. Part 2: Malignant Tumours, T. I. Budhy, S. D. Soenarto, H. B. Yaacob, W.C. Ngeow Dec 2001

Changing Incidence Of Oral And Maxillofacial Tumours In East Java, Indonesia, 1987-1992. Part 2: Malignant Tumours, T. I. Budhy, S. D. Soenarto, H. B. Yaacob, W.C. Ngeow

Wei Cheong Ngeow

A total of 2193 tumours of the mouth and jaw diagnosed at the Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Airlangga, Indonesia from 1987 to 1992, inclusive, was studied. Malignant tumours constituted 45.3% of the lesions. Almost 71% of the malignant tumours were squamous cell carcinomas. The remainder were salivary gland tumours (21.5%) and sarcomas (4.5%). The male to female ratio for malignant tumours was 5.1:4.7. The incidence of malignant tumours per 100,000 population over the 6-year study period was 2.64. The yearly incidence seemed to increase except in 1990, when it dropped ...