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Full-Text Articles in Medicine and Health Sciences

Front Matter Dec 1969

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.


The Prevalence Rate Of Congenital Heart Disease In Newborn Gerbils (Meriones Unguiculatus): A Preliminary Report, Jami G. Shakibi, Lester Weiss Dec 1969

The Prevalence Rate Of Congenital Heart Disease In Newborn Gerbils (Meriones Unguiculatus): A Preliminary Report, Jami G. Shakibi, Lester Weiss

Henry Ford Hospital Medical Journal

A preliminary report on the prevalence rate of congenital heart disease in newborn gerbils (Meriones unguiculatus) is presented. Serial sections of the entire heart of 100 liveborn gerbils were studied. The prevalence rate of congenital heart disease was 4%. Ventricular septal defect was the most frequent lesion. This is in agreement with previous reports on rats.


Cation Transport I. Metabolic Activity Of The Polyphosphoinositide Complex In Isolated Renal Cortex Tubules, Paul Bartlett, James F. Bossart Dec 1969

Cation Transport I. Metabolic Activity Of The Polyphosphoinositide Complex In Isolated Renal Cortex Tubules, Paul Bartlett, James F. Bossart

Henry Ford Hospital Medical Journal

Although several mechanisms have been proposed to explain the transport of hydrophylilc cations across lipoprotein barriers, the nature and identity of the carrier mechanism have not yet been elucidated. The present communication is concerned with a mechanism postulating that monoesterified phosphate on the inositol moiety of phosphatidyl inositol might provide anionic sites that function as cation carriers via a phosphorylation-dephosphorylation cycle, catalyzed in its simplest sequence by phosphatidyl inositol kinase and diphosphoinositide phosphomonoesterase activities. In this context, one might reasonably expect that turnover of monoesterified phosphate in the polyphosphoinositides of isolated renal cortex tubules would be reduced in tubules in ...


Evaluation Of Cellular-Level Haversian Bone Resorption In Human Hyperparathyroid States: A Preliminary Report, H. M. Frost, A. R. Villanueva, Z. F. Jaworski, P. Meunier, A. G. Shimizu Dec 1969

Evaluation Of Cellular-Level Haversian Bone Resorption In Human Hyperparathyroid States: A Preliminary Report, H. M. Frost, A. R. Villanueva, Z. F. Jaworski, P. Meunier, A. G. Shimizu

Henry Ford Hospital Medical Journal

Cellular-level bone resorption was evaluated in 16 patients undergoing renal dialysis and in two with primary hyperparathyroidism, by quantitative histological means using tissue time markers. When averaged over periods greater than two weeks, the individual osteoclasts in these patients resorbed less bone in unit time than normal.


The Mechanism Of Formation Of Certain Ventricular Septal Defects: A New Hypothesis, Jami G. Shakibi, Lester Weiss Dec 1969

The Mechanism Of Formation Of Certain Ventricular Septal Defects: A New Hypothesis, Jami G. Shakibi, Lester Weiss

Henry Ford Hospital Medical Journal

The generally accepted and most common mechanism of the pathogenesis of VSD is the failure of fusion of the conus ridges, atrioventricular cushions and the ventricular muscular septum. Our findings in a study of serial sections of the hearts of newborn gerbils (Meriones unguiculatus) leads us to hypothesize a second, less common, mechanism for the development of VSD, i.e., an exaggeration of the normal process of resorption and atrophy which undermines the septal cusp of the tricuspid valve, thus separating it from the muscular septum. This hypothesis can explain an instance of high membranous VSD in the form of ...


Photographic Features Of Benign And Malignant Ulcers, N. V. Carandang, B. M. Schuman, R. J. Priest Dec 1969

Photographic Features Of Benign And Malignant Ulcers, N. V. Carandang, B. M. Schuman, R. J. Priest

Henry Ford Hospital Medical Journal

One hundred and twenty-nine cases of benign gastric ulcer and 17 cases of malignant gastric ulcer studied by intragastric photography are reviewed. The benign ulcer, characterized by symmetrical contour and smooth base, was diagnosed correctly on the initial photographic study in 97.7% of cases. Malignant ulcers were diagnosed correctly in 59% of cases on the first study. The importance of color photography to complement roentgenographic evaluation of gastric ulceration is emphasized.


Hfh In The News Dec 1969

Hfh In The News

Henry Ford Hospital Medical Journal

No abstract provided.


Pneumatosis Cystoides Intestinalis: The Report Of A Case Associated With Severe Pulmonary Disease And Chronic Lymphocytic Leukemia, Russell J. Crider, Philip Bentlif Dec 1969

Pneumatosis Cystoides Intestinalis: The Report Of A Case Associated With Severe Pulmonary Disease And Chronic Lymphocytic Leukemia, Russell J. Crider, Philip Bentlif

Henry Ford Hospital Medical Journal

Pneumatosis cystoides intestinalis is discussed with emphasis on its clinical, radiologic, sigmoidoscopic, surgical and pathological characteristics. The four theories of the etiology of P.Cl. are neoplastic, infectious, nutritional, and mechanical. These theories are discussed, and a case of P.C.I, associated with severe pulmonary disease and chronic lymphocytic leukemia is presented to lend support to the mechanical theory.


Alcaptonuria And Ochronosis With Diabetes Mellitus And Mycosis Fungoides: A Case Report, Jamshed U. Haq, Roy B. Patton Dec 1969

Alcaptonuria And Ochronosis With Diabetes Mellitus And Mycosis Fungoides: A Case Report, Jamshed U. Haq, Roy B. Patton

Henry Ford Hospital Medical Journal

A Negro woman with alcaptonuria, ochronosis, ochronotic arthropathy, diabetes mellitus and mycosis fungoides died of acute renal failure due to diabetic glomerulonephropathy and ochronotic nephrosis. The role of the renal lesions of ochronosis is presented in potentiating the effect of an underlying renal disease producing rapidly progressive kidney failure. The occurrence of ochronosis, diabetes mellitus and mycosis fungoides is apparently coincidental only. Special stains of tissue sections confirm the similarity of melanin and ochronotlc pigment.


Promethazine-Chlorpromazine Combination In The Treatment Of Unmanageable Psychotic Patients, Armando R. Favazza Dec 1969

Promethazine-Chlorpromazine Combination In The Treatment Of Unmanageable Psychotic Patients, Armando R. Favazza

Henry Ford Hospital Medical Journal

Administering a combination of promethazine and chlorpromazine to patients with a "galloping psychosis" has an antipsychotic and tranquilizing effect which calms them down to a more manageable and less aggressive state. The drugs are chemically similar; promethazine's actions are strongly potentiated in the combination, so large doses must be given under careful supervision. Case histories demonstrate successful short term management of acutely psychotic, aggressive patients who were a danger to themselves and others.


"Anion-Gap Acidosis" Complicating Diabetic Ketoacidosis: A Commentary On Diagnosis And Management, J. Craig Jurgensen, Fred W. Whitehouse Dec 1969

"Anion-Gap Acidosis" Complicating Diabetic Ketoacidosis: A Commentary On Diagnosis And Management, J. Craig Jurgensen, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

No abstract provided.


Extrasensory Perception In Clinical Medicine, And Other Offenses, Susan Adelman Dec 1969

Extrasensory Perception In Clinical Medicine, And Other Offenses, Susan Adelman

Henry Ford Hospital Medical Journal

No abstract provided.


Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research Dec 1969

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.


Back Matter Dec 1969

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.


Studies Of The Electrical Parameters And Behavioral Effects Of An Eeg ''Seizure Discharge", W. R. Mccrum, R. M. Lee, H. Van Den Ende, L. D. Proctor, J. A. Lee Jun 1969

Studies Of The Electrical Parameters And Behavioral Effects Of An Eeg ''Seizure Discharge", W. R. Mccrum, R. M. Lee, H. Van Den Ende, L. D. Proctor, J. A. Lee

Henry Ford Hospital Medical Journal

Nemastrina monkeys with multiple electrodes implanted in the amygdaloid area of the brain were used to study the relationship of electrical seizures and overt behavior. The electrical seizures were produced by long duration electrical pulses administered through the implanted electrodes. There appears to be no relationship between this kind of electrical seizure and lever pressing performance. Relationships between depth EEG, depth impedance, DC potential and surface EEG are observed and as a consequence some ideas concerning the genesis of the electroencephalogram are put forth.


Sarcoidosis And Idiopathic Thrombocytopenic Purpura: First Report Of Coexistence, Ellis J. Vanslyck, Dipankarsri Dasgupta Jun 1969

Sarcoidosis And Idiopathic Thrombocytopenic Purpura: First Report Of Coexistence, Ellis J. Vanslyck, Dipankarsri Dasgupta

Henry Ford Hospital Medical Journal

A patient is described in whom sarcoidosis of the mediastinal lymph nodes was found during the course of acute idiopathic thrombocytopenic purpura. The association of these two diseases should be differentiated from the more commonly seen thrombocytopenia of hypersplenic origin, occurring during the disseminated stage of sarcoidosis, in which granulomatous involvement of an enlarged spleen is found. An elevated serum IgM immunoglobulin level was present. These observations possibly strengthen the concept that an immunological disorder plays a significant role in sarcoidosis.


The Clinical Use Of Fluorine18 In Bone Scanning, R. A. Gatesi, A. T. Vulpetti, T. L. Kosnik, W. G. Tucker, R. W. Talley Jun 1969

The Clinical Use Of Fluorine18 In Bone Scanning, R. A. Gatesi, A. T. Vulpetti, T. L. Kosnik, W. G. Tucker, R. W. Talley

Henry Ford Hospital Medical Journal

Roentgenograms are frequently inadequate in the detection of early osseous metastases. Isotope bone scan is a more sensitive diagnostic procedure. Reported here are findings on 40 patients with known or suspected osseous involvement using the short-lived radionuclide 18F. Comparison with standard roentgenograms and clinical follow-up demonstrated 11 early detections. 18F was found to be a very suitable agent for isotope bone scanning. Ilustrative cases are presented


Hfh In The News Jun 1969

Hfh In The News

Henry Ford Hospital Medical Journal

No abstract provided.


Isotope Cisternography — Risa®, J. L. Fenton, W. R. Eyler, L. A. Dusault, G. M. Griser, F. C. Stebner Jun 1969

Isotope Cisternography — Risa®, J. L. Fenton, W. R. Eyler, L. A. Dusault, G. M. Griser, F. C. Stebner

Henry Ford Hospital Medical Journal

Several cases are presented which illustrate the indications and results of a relatively new procedure of intrathecal injection of radioiodinated human seruin albumin I 131 to demonstrate cerebrospinal fluid dynamics. This procedure has been used in conjunction with pneumoencephalography in the diagnosis of communicating hydrocephalus. A proper dose as well as adequate volume are necessary to obtain diagnostic scans.


Primary Closure And Iliac Osteotomy In The Treatment Of Exstrophy Of The Bladder: A Case Report, Louis Z. Shifrin, Arthur Johnson, Lester Weiss Jun 1969

Primary Closure And Iliac Osteotomy In The Treatment Of Exstrophy Of The Bladder: A Case Report, Louis Z. Shifrin, Arthur Johnson, Lester Weiss

Henry Ford Hospital Medical Journal

Exstrophy of the bladder is a rare but serious congenital affliction. Untreated, exstrophy is associated with unacceptable morbidity and mortality. A case report is presented in which primary closure of the bladder and bilateral iliac osteotomy was successfully employed to gain anatomic correction of the bladder defect. However, the value of this surgical technique in restoring normal function of the lower urinary tract system is questionable.


The Vasopressor Effect Of Indigo Carmine, C. C. Wu, Arthur J. Johnson Jun 1969

The Vasopressor Effect Of Indigo Carmine, C. C. Wu, Arthur J. Johnson

Henry Ford Hospital Medical Journal

Indigo carmine only recently was found to have a vasopressor effect. Intravenous injection in anesthetized and unanesthetized patients resulted in blood pressure elevation and bradycardia. This effect appears analogous to that of serotonin which indigo carmine structurally resembles. This drug should be used with caution in patients with cardiovascular disease.


Nodular Excision Of Prostatic Carcinoma: Experience With Four Patients, E. E. Steinhardt, A. W. Bohne Jun 1969

Nodular Excision Of Prostatic Carcinoma: Experience With Four Patients, E. E. Steinhardt, A. W. Bohne

Henry Ford Hospital Medical Journal

No abstract provided.


Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research Jun 1969

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.


Front Matter Jun 1969

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.


A Preliminary Evaluation Of Azathioprine (Imuran®) In The Treatment Of Multiple Sclerosis, William G. Tucker, K. H. Kapphahn Jun 1969

A Preliminary Evaluation Of Azathioprine (Imuran®) In The Treatment Of Multiple Sclerosis, William G. Tucker, K. H. Kapphahn

Henry Ford Hospital Medical Journal

A theoretical approach to the unknown etiology of multiple sclerosis is presented in this preliminary study which reports the results of empiric treatment with azathioprine. Imuran® therapy produced stabilization of the disease, neurological improvement, and no progress of neurological dysfunction or loss of any regained function. Evidence points toward a viral-induced immunological defect. Abnormal gamma globulins found in the cerebral spinal fluid suggest an immunological etiology.


Etiology Of Congenital Heart Disease, Jami G. Shakibi Jun 1969

Etiology Of Congenital Heart Disease, Jami G. Shakibi

Henry Ford Hospital Medical Journal

The different factors involved in the etiology of congenital heart disease are discussed with particular attention lo the teratogenic agents. Experimental production of congenital heart disease in animals is reviewed. This seems to be a very promising field for investigations, which may eventually lead to an understanding of the etiology of congenital heart disease and its prevention.


Bovine Testicular Antihyaluronidase In Rabbits: Production And Purification, Gerald Fine, Sheikh M. Saeed, Gerald A. Logrippo Mar 1969

Bovine Testicular Antihyaluronidase In Rabbits: Production And Purification, Gerald Fine, Sheikh M. Saeed, Gerald A. Logrippo

Henry Ford Hospital Medical Journal

An antibody chemically and immunologically active against bovine testicular hyaluronidase was produced in rabbits by injecting them with purified hyaluronidase in complete Freund's adjuvant. Nonspecific antibodies, reacting with human and bovine proteins which had little or no hyaluronidase activity, were also detected by the double agar immunodiffusion technique using antiserum against these proteins. After absorption of the antiserum with bovine heart and liver and removal of the precipitation bands against human and bovine tissue proteins, the antiserum inhibited the chemical activity of the purified hyaluronidase and exhibited immunologic activity against the purified hyaluronidase as shown by the agar double ...


Slipped Capital Femoral Epiphysis (Follow-Up Study), C. Leslie Mitchell Mar 1969

Slipped Capital Femoral Epiphysis (Follow-Up Study), C. Leslie Mitchell

Henry Ford Hospital Medical Journal

Epiphyseolysis, or slipping of the capital femoral epiphysis, remains a controversial problem from the standpoint of etiology and treatment. This report is limited to results of treatment of severely slipped epiphyses at the Henry Ford Hospital from 1937 lo 1967. The surgical technique and postoperative care are described. Of a total of 137 hips treated surgically in this period, 38 were severe, requiring transcervical osteotomy and internal fixation. The follow-up results of these 38 cases are reported.


A Hazard Of "Diet Pop", Charles Wolf Mar 1969

A Hazard Of "Diet Pop", Charles Wolf

Henry Ford Hospital Medical Journal

Calorie-free carbonated beverages, or "diet pops," are becoming increasingly popular and many households no longer contain the older, more familiar, sugar containing, carbonated beverages. Because physicians frequently make use of "soda pop" when prescribing treatment for common pediatric conditions such as febrile episodes or bouts of vomiting or diarrhea, the following case report is presented to illustrate the fact that physicians must ascertain that the beverage to be used to maintain hydration is not calorie free.


Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research Mar 1969

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.