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Full-Text Articles in Medicine and Health Sciences

Depression And Prostate Cancer: Examining Comorbidity And Male-Specific Symptoms., Simon M Rice, John L Oliffe, Mary T Kelly, Prue Cormie, Suzanne K. Chambers, John S Ogrodniczuk, David Kealy Nov 2018

Depression And Prostate Cancer: Examining Comorbidity And Male-Specific Symptoms., Simon M Rice, John L Oliffe, Mary T Kelly, Prue Cormie, Suzanne K. Chambers, John S Ogrodniczuk, David Kealy

ECU Publications Post 2013

Depression in men with prostate cancer is a significant and complex issue that can challenge clinicians' diagnostic efforts. The objective of the current study was to evaluate prototypic and male-specific depression symptoms and suicidal ideation in men with a diagnosis of prostate cancer relative to those with and without comorbidity. The Patient Health Questionnaire-9 (PHQ-9) and Male Depression Risk Scale-22 (MDRS-22) were completed online along with demographic and background variables by 100 men with a diagnosis of prostate cancer ( n = 54 prostatectomy, n = 33 receiving active treatment). Hierarchical logistic regression was used to examine recent (past 2 weeks) suicide ideation ...


Mediterranean Diet Adherence And Rate Of Cerebral Aβ-Amyloid Accumulation: Data From The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing., Stephanie Rainey-Smith, Yian Gu, Samantha Gardener, James D Doecke, Victor L Villemagne, Belinda M Brown, Kevin Taddei, Simon M Laws, Hamid R. Sohrabi, Michael Weinborn, David Ames, Christopher Fowler, S Lance Macaulay, Paul Maruff, Colin L Masters, Olivier Salvado, Christopher C Rowe, Nikolaos Scarmeas, Ralph N. Martins Oct 2018

Mediterranean Diet Adherence And Rate Of Cerebral Aβ-Amyloid Accumulation: Data From The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing., Stephanie Rainey-Smith, Yian Gu, Samantha Gardener, James D Doecke, Victor L Villemagne, Belinda M Brown, Kevin Taddei, Simon M Laws, Hamid R. Sohrabi, Michael Weinborn, David Ames, Christopher Fowler, S Lance Macaulay, Paul Maruff, Colin L Masters, Olivier Salvado, Christopher C Rowe, Nikolaos Scarmeas, Ralph N. Martins

ECU Publications Post 2013

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron ...


Effect Of Natural Products On The Production And Activity Of Clostridium Difficile Toxins In Vitro., Niloufar Roshan, Thomas Riley, Daniel R Knight, Katherine A Hammer Oct 2018

Effect Of Natural Products On The Production And Activity Of Clostridium Difficile Toxins In Vitro., Niloufar Roshan, Thomas Riley, Daniel R Knight, Katherine A Hammer

ECU Publications Post 2013

Clostridium difficile infection is a toxin-mediated disease of the colon. C. difficile virulence is primarily attributed to the production of toxin A and toxin B; thus this study was aimed to investigate the effect of a range of natural products on the production and activity of C. difficile toxins in vitro. Twenty-two natural products were investigated against four C. difficile strains. The activity of products against toxins was determined using Vero and HT-29 cells cytotoxicity and neutral red uptake assays. The indirect effect of products on toxin-mediated cytotoxicity was determined using the same cell lines. The effect of seven products ...


Spatial And Temporal Clustering Analysis Of Tuberculosis In The Mainland Of China At The Prefecture Level, 2005-2015., Meng-Yang Liu, Qi-Huan Li, Ying-Jie Zhang, Yuan Ma, Yue Liu, Wei Feng, Cheng-Bei Hou, Endawoke Amsalu, Xia Li, Wei Wang, Wei-Min Li, Xiu-Hua Guo Oct 2018

Spatial And Temporal Clustering Analysis Of Tuberculosis In The Mainland Of China At The Prefecture Level, 2005-2015., Meng-Yang Liu, Qi-Huan Li, Ying-Jie Zhang, Yuan Ma, Yue Liu, Wei Feng, Cheng-Bei Hou, Endawoke Amsalu, Xia Li, Wei Wang, Wei-Min Li, Xiu-Hua Guo

ECU Publications Post 2013

BACKGROUND: Tuberculosis (TB) is still one of the most serious infectious diseases in the mainland of China. So it was urgent for the formulation of more effective measures to prevent and control it.

METHODS: The data of reported TB cases in 340 prefectures from the mainland of China were extracted from the China Information System for Disease Control and Prevention (CISDCP) during January 2005 to December 2015. The Kulldorff's retrospective space-time scan statistics was used to identify the temporal, spatial and spatio-temporal clusters of reported TB in the mainland of China by using the discrete Poisson probability model. Spatio-temporal ...


The Impact Of Stuttering On Development Of Self-Identity, Relationships, And Quality Of Life In Women Who Stutter, Charn Nang, Deborah J. Hersh, Katie Milton, Su Re Lau Oct 2018

The Impact Of Stuttering On Development Of Self-Identity, Relationships, And Quality Of Life In Women Who Stutter, Charn Nang, Deborah J. Hersh, Katie Milton, Su Re Lau

ECU Publications Post 2013

Purpose: The experiences of women who stutter have been underresearched. Clinicians have little guidance from the research literature on issues specific to women who stutter and are likely to have less clinical contact with this group than with men who stutter because of the higher prevalence of stuttering in men. This study explored the experiences of a small group of women who stutter with a particular focus on what the main current issues are and how gender may have influenced experiences with stuttering.

Method: This qualitative study involved recruitment of 9 women who stutter (aged 35-80 years) through a support ...


Computerised Dynamic Posturography In Premanifest And Manifest Individuals With Huntington's Disease., Alvaro Reyes, Danielle Salomonczyk, Wei-Peng Teo, Luis D Medina, Danielle Bartlett, Eva Pirogovsky-Turk, Pauline Zaenker, Jody Corey Bloom, Roger W Simmons, Mel R. Ziman, Paul E Gilbert, Travis Miles Cruickshank Oct 2018

Computerised Dynamic Posturography In Premanifest And Manifest Individuals With Huntington's Disease., Alvaro Reyes, Danielle Salomonczyk, Wei-Peng Teo, Luis D Medina, Danielle Bartlett, Eva Pirogovsky-Turk, Pauline Zaenker, Jody Corey Bloom, Roger W Simmons, Mel R. Ziman, Paul E Gilbert, Travis Miles Cruickshank

ECU Publications Post 2013

Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington's disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more ...


Statistical Analysis Plan (Sap) For The Very Early Rehabilitation In Speech (Verse) After Stroke Trial: An International 3-Arm Clinical Trial To Determine The Effectiveness Of Early, Intensive, Prescribed, Direct Aphasia Therapy., Erin Godecke, Tapan Rai, Dominique A Cadilhac, Elizabeth Armstrong, Sandy Middleton, Natalie Ciccone, Anne Whitworth, Miranda L Rose, Audrey Holland, Fiona Ellery, Graeme J Hankey, Julie Bernhardt Oct 2018

Statistical Analysis Plan (Sap) For The Very Early Rehabilitation In Speech (Verse) After Stroke Trial: An International 3-Arm Clinical Trial To Determine The Effectiveness Of Early, Intensive, Prescribed, Direct Aphasia Therapy., Erin Godecke, Tapan Rai, Dominique A Cadilhac, Elizabeth Armstrong, Sandy Middleton, Natalie Ciccone, Anne Whitworth, Miranda L Rose, Audrey Holland, Fiona Ellery, Graeme J Hankey, Julie Bernhardt

ECU Publications Post 2013

Background Limited evidence exists to support very early intensive aphasia rehabilitation after stroke. VERSE is a PROBE trial designed to determine whether two types of intensive aphasia therapy, beginning within 14 days of acute stroke, provide greater therapeutic and cost-effectiveness than usual care. Objective To publish the detailed statistical analysis plan for the VERSE trial prior to unblinding. This statistical analysis plan was based on the published and registered VERSE trial protocol and was developed by the blinded steering committee and management team, led by the trial statistician. This plan was developed using outcome measures and trial data collection forms ...


A Prospective Cohort Examination Of Haematological Parameters In Relation To Cancer Death And Incidence: The Busselton Health Study., Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder, John K. Olynyk Sep 2018

A Prospective Cohort Examination Of Haematological Parameters In Relation To Cancer Death And Incidence: The Busselton Health Study., Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder, John K. Olynyk

ECU Publications Post 2013

BACKGROUND: Cancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.

METHODS: We studied 1564 men and 1769 women who were enrolled in the Busselton Health Study, Western Australia. Haematological parameters evaluated included haemoglobin (Hb), mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) and red cell distribution width (RCDW). Statistical analyses included t-tests for quantitative variables, chi-square tests for categorical variables and Cox proportional hazards regression modelling for cancer incidence and death.

RESULTS ...


The Association Between Subclass-Specific Igg Fc N-Glycosylation Profiles And Hypertension In The Uygur, Kazak, Kirgiz, And Tajik Populations., Jn Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, J Zhang, Hao Wang, Dq Zheng, Xy Zhang, Hl Peng, Zy Zhao, Di Liu, Yang Sun, Qi Sun, Qh Li, Jx Zhang, Ming Sun, Wj Cao, Ana Momčilović, Genadij Razdorov, Lj Wu, Alyce Russell, Yx Wang, Song Manshu, Gordan Lauc, Wei Wang Sep 2018

The Association Between Subclass-Specific Igg Fc N-Glycosylation Profiles And Hypertension In The Uygur, Kazak, Kirgiz, And Tajik Populations., Jn Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, J Zhang, Hao Wang, Dq Zheng, Xy Zhang, Hl Peng, Zy Zhao, Di Liu, Yang Sun, Qi Sun, Qh Li, Jx Zhang, Ming Sun, Wj Cao, Ana Momčilović, Genadij Razdorov, Lj Wu, Alyce Russell, Yx Wang, Song Manshu, Gordan Lauc, Wei Wang

ECU Publications Post 2013

Hypertension results from the interaction of genetic and acquired factors. IgG occurs in the form of different subclasses, of which the effector functions show significant variation. The detailed differences between the glycosylation profiles of the individual IgG subclasses may be lost in a profiling method for total IgG N-glycosylation. In this study, subclass-specific IgG Fc glycosylation profile was investigated in the four northwestern Chinese minority populations, namely, Uygur (UIG), Kazak (KZK), Kirgiz (KGZ), and Tajik (TJK), composed of 274 hypertensive patients and 356 healthy controls. The results showed that ten directly measured IgG N-glycan traits (i.e., IgG1G0F, IgG2G0F, IgG2G1FN ...


Keep Calm And Carry On: Parental Opinions On Improving Clinical Dietary Trials For Young Children, Analise Nicholl, Therese O'Sullivan Aug 2018

Keep Calm And Carry On: Parental Opinions On Improving Clinical Dietary Trials For Young Children, Analise Nicholl, Therese O'Sullivan

ECU Publications Post 2013

Recruitment can be an issue for paediatric research. We aimed to investigate parental opinions of paediatric clinical assessments, and to combine findings with recent literature to inform the design of a clinical dietary trial. We used convenience sampling to recruit 17 parents of children aged 2⁻6 years from two community playgroups in Perth, Western Australia. Three focus groups considered proposed child assessments, study design, and potential study enrolment. Qualitative thematic analysis of focus group transcripts used NVivo 11 (QSR, Melbourne, VIC, Australia). Four main parental concerns emerged, presented here with solutions combining parent responses and relevant literature. (1) Parent ...


Characterisation Of The Structure And Oligomerisation Of Islet Amyloid Polypeptides (Iapp): A Review Of Molecular Dynamics Simulation Studies, Sandra J Moore, Krushna Sonar, Prashant Bharadwaj, Evelyne Deplazes, Ricardo L Mancera Aug 2018

Characterisation Of The Structure And Oligomerisation Of Islet Amyloid Polypeptides (Iapp): A Review Of Molecular Dynamics Simulation Studies, Sandra J Moore, Krushna Sonar, Prashant Bharadwaj, Evelyne Deplazes, Ricardo L Mancera

ECU Publications Post 2013

Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein whose abnormal aggregation into amyloid fibrils is a pathological feature in type 2 diabetes, and its cross-aggregation with amyloid beta has been linked to an increased risk of Alzheimer's disease. The soluble, oligomeric forms of hIAPP are the most toxic to β-cells in the pancreas. However, the structure of these oligomeric forms is difficult to characterise because of their intrinsic disorder and their tendency to rapidly aggregate into insoluble fibrils. Experimental studies of hIAPP have generally used non-physiological conditions to prevent aggregation, and they have been unable ...


Implementation Of Continuous Quality Improvement In Aboriginal And Torres Strait Islander Primary Health Care In Australia: A Scoping Systematic Review., Karen Gardner, Beverly Sibthorpe, Mier Chan, Ginny Sargent, Michelle Dowden, Daniel Mcaullay Jul 2018

Implementation Of Continuous Quality Improvement In Aboriginal And Torres Strait Islander Primary Health Care In Australia: A Scoping Systematic Review., Karen Gardner, Beverly Sibthorpe, Mier Chan, Ginny Sargent, Michelle Dowden, Daniel Mcaullay

ECU Publications Post 2013

BACKGROUND: Continuous Quality Improvement (CQI) programs have been taken up widely by Indigenous primary health care (PHC) services in Australia and there has been national policy commitment to support this. However, international evidence shows that implementing CQI is challenging, impacts are variable and little is known about the factors that impede or enhance effectiveness. A scoping review was undertaken to explore uptake and implementation in Indigenous PHC, including barriers and enablers to embedding CQI in routine practice. We provide guidance on how research and evaluation might be intensified to support implementation.

METHODS: Searches were conducted in MEDLINE, CINAHL and the ...


Intense Exercise For Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (Interval-Gap4): A Multicentre, Randomised, Controlled Phase Iii Study Protocol, Robert Newton, Stacey A Kenfield, Nicolas H. Hart, June M Chan, Kerry S. Courneya, James Catto, Stephen P Finn, Rosemary Greenwood, Daniel C Hughes, Lorelei Mucci, Stephen R Plymate, Stephan F E Praet, Emer M Guinan, Erin L Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A. Galvao, Charles J Ryan, Fred Saad May 2018

Intense Exercise For Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (Interval-Gap4): A Multicentre, Randomised, Controlled Phase Iii Study Protocol, Robert Newton, Stacey A Kenfield, Nicolas H. Hart, June M Chan, Kerry S. Courneya, James Catto, Stephen P Finn, Rosemary Greenwood, Daniel C Hughes, Lorelei Mucci, Stephen R Plymate, Stephan F E Praet, Emer M Guinan, Erin L Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A. Galvao, Charles J Ryan, Fred Saad

ECU Publications Post 2013

INTRODUCTION: Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC).

METHODS AND ANALYSIS: Participants (n=866) must have histologically documented metastatic prostate cancer with evidence of progressive disease on androgen deprivation therapy (defined as mCRPC). Patients can be treatment-naïve for mCRPC or on first-line androgen receptor-targeted therapy for mCRPC (ie, abiraterone or enzalutamide) without evidence of progression at enrolment, and with no prior chemotherapy for mCRPC ...


What Are The Characteristics Of Vitamin D Metabolism In Opioid Dependence? An Exploratory Longitudinal Study In Australian Primary Care., Albert Stuart Reece, Gary Hulse Jan 2018

What Are The Characteristics Of Vitamin D Metabolism In Opioid Dependence? An Exploratory Longitudinal Study In Australian Primary Care., Albert Stuart Reece, Gary Hulse

ECU Publications Post 2013

OBJECTIVE: Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of intracellular metabolism and comprise an important site of pathophysiological immune and metabolic dysregulation potentially contributing towards pro-ageing changes observed in opioid-dependent patients (ODPs).

DESIGN: Longitudinal prospective comparing ODPs with general medical controls (GMCs).

SETTING: Primary care.

PARTICIPANTS: Prospective review comparing 1168 ODP (72.5% men) and 415 GMC (51.6% men, p

INTERVENTIONS: Nil. Observational study only.

PRIMARY AND SECONDARY OUTCOMES: Serum vitamin D levels ...


Effect Of Water Immersion Temperature On Heart Rate Variability Following Exercise In The Heat, Hui C. Choo, Kazunori Nosaka, Jeremiah J. Peiffer, Mohammed Ihsan, Chow C. Yeo, Chris R. Abbiss Jan 2018

Effect Of Water Immersion Temperature On Heart Rate Variability Following Exercise In The Heat, Hui C. Choo, Kazunori Nosaka, Jeremiah J. Peiffer, Mohammed Ihsan, Chow C. Yeo, Chris R. Abbiss

ECU Publications Post 2013

This study compared the effect of passive rest (CON) and water immersion at 8.6±0.2°C (CWI9), 14.6±0.3°C (CWI15) and 35.0±0.4°C (thermoneutral water immersion [TWI]) on post-exercise heart rate variability (HRV) indices. In a climate chamber (32.8±0.4°C, 32±5% relative humidity), nine men completed 25 min of cycling at the first ventilatory threshold and repeated 30-second bouts at 90% of peak power followed by a 5-minute recovery treatment in a randomised crossover manner. All water immersion re-established the HRV indices (natural logarithm of the square root ...


Weight Loss Strategies In Combat Sports And Concerning Habits In Mixed Martial Arts, Oliver R. Barley, Dale W. Chapman, Chris Abbiss Jan 2018

Weight Loss Strategies In Combat Sports And Concerning Habits In Mixed Martial Arts, Oliver R. Barley, Dale W. Chapman, Chris Abbiss

ECU Publications Post 2013

Context: Combat sports are typically divided into weight classes, and body-mass manipulation to reach a weight class is commonplace. Previous research suggests that weight loss practices in mixed martial arts (MMA) may be more extreme than in other combat sports.

Purpose: To investigate the magnitude of weight loss and the prevalence of weight loss strategies in different combat sports.

Methods: Competitors (N = 637) from Brazilian jiu-jitsu, boxing, judo, MMA, Muay Thai/kickboxing, taekwondo, and wrestling completed an online questionnaire seeking information regarding their weight loss practices.

Results: Body-mass manipulation was commonly undertaken by all combat-sport athletes, with a particularly high ...


Association Of Obstructive Sleep Apnea With Hypertension: A Systematic Review And Meta-Analysis, Haifeng Hou, Yange Zhao, Xiaotong Xue, Jian Ding, Wei Jia Xing, Wei Wang Jan 2018

Association Of Obstructive Sleep Apnea With Hypertension: A Systematic Review And Meta-Analysis, Haifeng Hou, Yange Zhao, Xiaotong Xue, Jian Ding, Wei Jia Xing, Wei Wang

ECU Publications Post 2013

Results: Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980, P < 0.05). Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 (95% CI = 1.093-1.274, P < 0.05) for mild OSA, 1.316 (95% CI = 1.197-1.433, P < 0.05) for moderate OSA and 1.561 (95% CI = 1.287-1.835, P < 0.05) for severe OSA.

Conclusions: Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients.

Background: Obstructive sleep apnea (OSA) is a ...


An Ehealth Program For Patients Undergoing A Total Hip Arthroplasty: Protocol For A Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Catherine Ashford, Trudy Sullivan, Judith Mcdowall, Lisa Whitehead, Bev Ewens, Kathryn Pedler, Karen Gullick Jan 2018

An Ehealth Program For Patients Undergoing A Total Hip Arthroplasty: Protocol For A Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Catherine Ashford, Trudy Sullivan, Judith Mcdowall, Lisa Whitehead, Bev Ewens, Kathryn Pedler, Karen Gullick

ECU Publications Post 2013

Background: Total hip arthroplasty is an effective surgical procedure commonly used worldwide for patients suffering the disabling effects of osteoarthritis when medical therapy is unsuccessful. Traditionally pre- and postoperative information for patients undergoing a hip arthroplasty has been provided by paper-based methods. Electronic health (eHealth) programs to support individualized patient education on preoperative preparation, in-patient care, and home rehabilitation have the potential to increase patient engagement, enhance patient recovery, and reduce potential postoperative complications.

Objective: The aim of this study is to compare the addition of an eHealth program versus standard care for pre- and postoperative education on patient outcomes ...


Relationship Between Strength And Power Production Capacities In Trained Sprint Track Cyclists, James Vercoe, Mike R. Mcguigan Jan 2018

Relationship Between Strength And Power Production Capacities In Trained Sprint Track Cyclists, James Vercoe, Mike R. Mcguigan

ECU Publications Post 2013

The purpose of this study was to investigate the relationship between strength and power capabilities in trained sprint track cyclists. Ten participants including six women and four men (age: 22.1±6.8 years, body height: 176.1±6.7 cm, body weight: 72.1±7.9 kg) performed isometric mid-thigh pull (IMTP) and isokinetic sprint tests. Variables measured included peak force (PF), peak rate of force development (PRFD) for the IMTP and maximal torque and maximal power (Pmax) for the isokinetic sprint test. There was a strong relationship between PF on the IMTP and maximal peak torque values across ...


Experiences Of Australian Men Diagnosed With Advanced Prostate Cancer: A Qualitative Study, Suzanne K. Chambers, Melissa K. Hyde, Kirstyn Laurie, Melissa Legg, Mark Frydenberg, Ian D. Davis, Anthony P. Lowe, Jeff Dunn Jan 2018

Experiences Of Australian Men Diagnosed With Advanced Prostate Cancer: A Qualitative Study, Suzanne K. Chambers, Melissa K. Hyde, Kirstyn Laurie, Melissa Legg, Mark Frydenberg, Ian D. Davis, Anthony P. Lowe, Jeff Dunn

ECU Publications Post 2013

Objective To explore men's lived experience of advanced prostate cancer (PCa) and preferences for support. Design Cross-sectional qualitative study applying open-ended surveys and interviews conducted between June and November 2016. Interviews audio-recorded and transcribed verbatim and analysed from an interpretive phenomenological perspective. Setting Australia, nation-wide. Participants 39 men diagnosed with advanced PCa (metastatic or castration-resistant biochemical progression) were surveyed with 28 men subsequently completing a semistructured in depth telephone interview. Results Thematic analysis of interviews identified two organising themes: lived experience and supportive care. Lived experience included six superordinate themes: regret about late diagnosis and treatment decisions, being discounted ...


Predictors Of Noncompliance To Antihypertensive Therapy Among Hypertensive Patients Ghana: Application Of Health Belief Model, Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah Jan 2018

Predictors Of Noncompliance To Antihypertensive Therapy Among Hypertensive Patients Ghana: Application Of Health Belief Model, Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah

ECU Publications Post 2013

This study determined noncompliance to antihypertensive therapy (AHT) and its associated factors in a Ghanaian population by using the health belief model (HBM). This descriptive cross-sectional study conducted at Kintampo Municipality in Ghana recruited a total of 678 hypertensive patients. The questionnaire constituted information regarding sociodemographics, a five-Likert type HBM questionnaire, and lifestyle-related factors. The rate of noncompliance to AHT in this study was 58.6%. The mean age (SD) of the participants was 43.5 (±5.2) years and median duration of hypertension was 2 years. Overall, the five HBM constructs explained 31.7% of the variance in noncompliance ...


Whole Body Vibration Exposure On Markers Of Bone Turnover, Body Composition, And Physical Functioning In Breast Cancer Patients Receiving Aromatase Inhibitor Therapy: A Randomized Controlled Trial, Michael K. Baker, Carolyn J. Mcintyre, Daniel A. Galvão, Catherine Hunt, Nigel Spry, Robert Newton Jan 2018

Whole Body Vibration Exposure On Markers Of Bone Turnover, Body Composition, And Physical Functioning In Breast Cancer Patients Receiving Aromatase Inhibitor Therapy: A Randomized Controlled Trial, Michael K. Baker, Carolyn J. Mcintyre, Daniel A. Galvão, Catherine Hunt, Nigel Spry, Robert Newton

ECU Publications Post 2013

Introduction: Women with breast cancer are often prescribed aromatase inhibitors, which can cause rapid loss of bone mass leading to significant potential for morbidity. Vibration training has been shown to be helpful in reducing bone turnover in postmenopausal women without cancer.

Aim: To examine the effect of vibration stimulus on markers of bone turnover in breast cancer patients receiving aromatase inhibitors.

Methods: Thirty-one breast cancer survivors undergoing treatment with aromatase inhibitors were randomized to vibration stimulus (n = 14) or usual care control (n = 17). Low-frequency and low-magnitude vibration stimulus (27-32 Hz, 0.3g) was delivered in supervised sessions via ...


White Matter Hyperintensities And The Mediating Role Of Cerebral Amyloid Angiopathy In Dominantly-Inherited Alzheimer’S Disease, Seonjoo Lee, Molly E. Zimmerman, Atul Narkhede, Sara E. Nasrabady, Giuseppe Tosto, Irene B. Meier, Tammie L.S. Benzinger, Daniel S. Marcus, Anne M. Fagan, Nick C. Fox, Nigel J. Cairns, David M. Holtzman, Virginia Buckles, Bernardino Ghetti, Eric Mcdade, Ralph Martins, Andrew J. Saykin, Colin L. Masters, John M. Ringman, Stefan Fӧrster, Peter R. Schofield, Reisa A. Sperling, Keith A. Johnson, Jasmeer P. Chhatwal, Stephen Salloway, Stephen Correia, Clifford R. Jack, Jr, Michael Weiner, Randall J. Bateman, John C. Morris, Richard Mayeux, Adam M. Brickman Jan 2018

White Matter Hyperintensities And The Mediating Role Of Cerebral Amyloid Angiopathy In Dominantly-Inherited Alzheimer’S Disease, Seonjoo Lee, Molly E. Zimmerman, Atul Narkhede, Sara E. Nasrabady, Giuseppe Tosto, Irene B. Meier, Tammie L.S. Benzinger, Daniel S. Marcus, Anne M. Fagan, Nick C. Fox, Nigel J. Cairns, David M. Holtzman, Virginia Buckles, Bernardino Ghetti, Eric Mcdade, Ralph Martins, Andrew J. Saykin, Colin L. Masters, John M. Ringman, Stefan Fӧrster, Peter R. Schofield, Reisa A. Sperling, Keith A. Johnson, Jasmeer P. Chhatwal, Stephen Salloway, Stephen Correia, Clifford R. Jack, Jr, Michael Weiner, Randall J. Bateman, John C. Morris, Richard Mayeux, Adam M. Brickman

ECU Publications Post 2013

Introduction: White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer’s disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of cerebral amyloid angiopathy (CAA) and that increased WMH in this population is a manifestation of this vascular form of primary AD pathology. We examined whether the presence of cerebral microbleeds, a marker of CAA, mediates the relationship between WMH and estimated symptom onset in individuals with and without autosomal dominant mutations for AD.

Participants and methods: Participants (n = 175, mean age ...


Intrarater Reliability And Agreement Of The Physioflow Bioimpedance Cardiography Device During Rest, Moderate And High-Intensity Exercise, Nicole Gordon, Chris R. Abbiss, Andrew J. Maiorana, Kieran J. Marston, Jeremiah J. Peiffer Jan 2018

Intrarater Reliability And Agreement Of The Physioflow Bioimpedance Cardiography Device During Rest, Moderate And High-Intensity Exercise, Nicole Gordon, Chris R. Abbiss, Andrew J. Maiorana, Kieran J. Marston, Jeremiah J. Peiffer

ECU Publications Post 2013

The PhysioFlow bioimpedance cardiography device provides key measures of central systolic and diastolic and peripheral vascular function. Many of these variables have not been assessed for intrarater reliability and agreement during rest, submaximal exercise and high-intensity interval exercise. Twenty healthy adults (age: 26±4 years) completed two identical trials beginning with five minutes of rest followed by two 5-minute submaximal cycling bouts at 50% and 70% of peak power output. Subjects then completed ten 30-second cycling intervals at 90% of peak power output interspersed with 60 s of passive recovery. Bioimpedance cardiography (PhysioFlow; Manatec Biomedical, France) monitored heart rate, stroke ...


The Frequency Of Drd2 Rs1076560 And Oprm1 Rs1799971 In Substance Use Disorder Patients From The United Arab Emirates, Hiba Alblooshi, Gary Hulse, Wael Osman, Ahmed El Kashef, Mansour Shawky, Hamad Al Ghaferi, Habiba Al Safar, Kwang Guan Tay Jan 2018

The Frequency Of Drd2 Rs1076560 And Oprm1 Rs1799971 In Substance Use Disorder Patients From The United Arab Emirates, Hiba Alblooshi, Gary Hulse, Wael Osman, Ahmed El Kashef, Mansour Shawky, Hamad Al Ghaferi, Habiba Al Safar, Kwang Guan Tay

ECU Publications Post 2013

Background - Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations with substance use disorder (SUD) in various populations. This study is the first study to determine the allele frequency and the genetic association of the DRD2 rs1076560 SNP and OPRM1 rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE).

Methods - A cross-sectional case–control cohort that consisted of 512 male subjects was studied. Two hundred and fifty patients with SUD receiving treatment ...


Association Of Wrist Circumference And Waist-To-Height Ratio With Cardiometabolic Risk Factors Among Type Ii Diabetics In A Ghanaian Population, Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya Jan 2018

Association Of Wrist Circumference And Waist-To-Height Ratio With Cardiometabolic Risk Factors Among Type Ii Diabetics In A Ghanaian Population, Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya

ECU Publications Post 2013

The study determined the association of wrist circumference (WrC) and waist-to-height ratio (WHtR) with cardiometabolic risk factors among diabetics in a Ghanaian population. This cross-sectional study involved 384 diabetic patients at Begoro District Hospital, Ghana. Blood pressure, anthropometrics, and biochemical indices were measured. The overall prevalence of dyslipidaemia, metabolic syndrome (MetS), and hypertension was 42.4%, 76.3%, and 39.8%, respectively. The optimum cut-off range of WrC to identify individuals at increased cardiometabolic risk was 17.5 to –17.8 cm for men and 16.0 to 16.7 cm for women while that of WHtR was 0.52 ...


The Effects Of Acute And Chronic Sprint-Interval Training On Cytokine Responses Are Independent Of Prior Caffeine Intake, Guilherme Ferreira, Leandro Felippe, Rômulo Bertuzzi, David Bishop, Emiliano Barreto, Fernando De-Oliveira, Adriano Lima-Silva Jan 2018

The Effects Of Acute And Chronic Sprint-Interval Training On Cytokine Responses Are Independent Of Prior Caffeine Intake, Guilherme Ferreira, Leandro Felippe, Rômulo Bertuzzi, David Bishop, Emiliano Barreto, Fernando De-Oliveira, Adriano Lima-Silva

ECU Publications Post 2013

We examined the effect of acute and chronic sprint interval training (SIT), with or without prior caffeine intake, on levels of exercise-induced inflammatory plasma cytokines [interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α]. Twenty physically-active men ingested either a placebo (n = 10) or caffeine (n = 10) 1 h before each SIT session(13-s × 30-s sprint/15 s of rest) during six training sessions (2 weeks). The early (before, immediately after, and 45 min after the exercise) and late (24 and 48 h after the exercise) cytokine and creatine kinase (CK) responses were analyzed for the first and last training ...


Uv Light-Blocking Contact Lenses Protect Against Short-Term Uvb-Induced Limbal Stem Cell Niche Damage And Inflammation., M. Notara, S. Behboudifard, M. A. Kluth, C. Maßlo, C. Ganss, M. H. Frank, B. Schumacher, C. Cursiefen Jan 2018

Uv Light-Blocking Contact Lenses Protect Against Short-Term Uvb-Induced Limbal Stem Cell Niche Damage And Inflammation., M. Notara, S. Behboudifard, M. A. Kluth, C. Maßlo, C. Ganss, M. H. Frank, B. Schumacher, C. Cursiefen

ECU Publications Post 2013

UVB irradiation has been linked to pathogenesis of pterygium, a conjunctival tumor growing onto transparent cornea, the windscreen of the eye. Due to corneal anatomy, ambient UVB irradiation is amplified at the stem cell-containing nasal limbus. The aim of this study was to analyse the effect of a UV-blocking contact lens (UVBCL, senofilcon A, Class 1 UV blocker) on limbal epithelial cells and fibroblasts under UVB irradiation compared to a non-UVB-blocking contact lens. UVBCL prevented UVB-induced DNA damage (as assessed by cyclobutane pyrimidine dimer immunostaining) as well as a decrease in proliferation and scratch wound closure rate of both limbal ...


Factors Affecting Powerlifting Performance: An Analysis Of Age- And Weight-Based Determinants Of Relative Strength, Christopher Latella, Daniel Van Den Hoek, Wei-Peng Teo Jan 2018

Factors Affecting Powerlifting Performance: An Analysis Of Age- And Weight-Based Determinants Of Relative Strength, Christopher Latella, Daniel Van Den Hoek, Wei-Peng Teo

ECU Publications Post 2013

Powerlifting (PL) is characterised by the ability to generate maximal force. However, an understanding of the factors affecting strength in PL athletes is poorly understood. Therefore, competition data were analysed from 1368 individuals during 2017. Relative strength was compared for the squat (SQ), bench press (BP) and deadlift (DL) between age groups (Sub-junior [SJ], Junior [JU], Open [OP], and Masters’ I-IV [M1-M4]), weight classes (females; 47 kg, 52 kg, 57 kg, 63 kg, 72 kg, 84 kg and + 84 kg and males; 59 kg, 66 kg, 74 kg, 83 kg, 93 kg, 105 kg, 120 kg, + 120 kg) and between ...


Vegetable Diversity, Injurious Falls, And Fracture Risk In Older Women: A Prospective Cohort Study, Marc Sim, Lauren C. Blekkenhorst, Joshua Lewis, Catherine P. Bondonno, Amanda Devine, Kun Zhu, Richard J. Woodman, Richard L. Price, Jonathan M. Hodgson Jan 2018

Vegetable Diversity, Injurious Falls, And Fracture Risk In Older Women: A Prospective Cohort Study, Marc Sim, Lauren C. Blekkenhorst, Joshua Lewis, Catherine P. Bondonno, Amanda Devine, Kun Zhu, Richard J. Woodman, Richard L. Price, Jonathan M. Hodgson

ECU Publications Post 2013

The importance of vegetable diversity for the risk of falling and fractures is unclear. Our objective was to examine the relationship between vegetable diversity with injurious falling and fractures leading to hospitalization in a prospective cohort of older Australian women (n = 1429, ≥70 years). Vegetable diversity was quantified by assessing the number of different vegetables consumed daily. Vegetable intake (75 g servings/day) was estimated using a validated food frequency questionnaire at baseline (1998). Over 14.5 years, injurious falls (events = 568, 39.7%), and fractures (events = 404, 28.3%) were captured using linked health records. In multivariable-adjusted Cox regression ...