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Full-Text Articles in Medicine and Health Sciences

Developing A Real-Time Translator From Neural Signals To Text: An Articulatory Phonetics Approach, Lindy Comstock, Ariel Tankus, Michelle Tran, Nader Pouratian, Itzhak Fried, William Speier Jan 2019

Developing A Real-Time Translator From Neural Signals To Text: An Articulatory Phonetics Approach, Lindy Comstock, Ariel Tankus, Michelle Tran, Nader Pouratian, Itzhak Fried, William Speier

Proceedings of the Society for Computation in Linguistics

New developments in brain-computer interfaces (BCI) harness machine learning to decode spoken language from electrocorticographic (ECoG) and local field potential (LFP) signals. Orienting to signals associated with motor movements that produce articulatory features improves phoneme detection quality: individual phonemes share features, but possess a unique feature set; classification by feature set allows for a finer distinction between neural signals. Data indicates vowels are more detectable, consonants have greater detection accuracy, place of articulation informs precision, and manner of articulation affects recall. Findings have implications for the multisensory integration of speech and the role of motor imagery in phonemic neural representations.


Multiple Regression Models To Analyze Length Of Hospitalization Due To Nosocomial Infections In U.S. Hospitals, Ernest M. Oleksy Dec 2018

Multiple Regression Models To Analyze Length Of Hospitalization Due To Nosocomial Infections In U.S. Hospitals, Ernest M. Oleksy

The Downtown Review

Nosocomial diseases are a serious concern and detriment to hospitals’ abilities to provide appropriate patient care. Bearing this in mind, an effort must be made to determine whether infection surveillance and control programs have reduced the rates of nosocomial infection at U.S. hospitals. The data that were studied were obtained as part of the Study on the Efficacy of Nosocomial Infection Control (SENIC) and used to develop a model of what variables most contribute to a patient’s length of stay at the Cleveland Clinic (Quade et al, 1980).


An Examination Of The Death Penalty, Alexandra N. Kremer Dec 2018

An Examination Of The Death Penalty, Alexandra N. Kremer

The Downtown Review

The death penalty, or capital punishment, is the use of execution through hanging, beheading, drowning, gas chambers, lethal injection, and electrocution among others in response to a crime. This has spurred much debate on whether it should be used for reasons such as ethics, revenge, economics, effectiveness as a deterrent, and constitutionality. Capital punishment has roots that date back to the 18th century B.C., but, as of 2016, has been abolished in law or practice by more than two thirds of the world’s countries and several states within the United States. Here, the arguments for and against ...


“A New Way Of Thinking”: Frantz Fanon’S True Opinion On Violence, Caroline D. Renko Dec 2018

“A New Way Of Thinking”: Frantz Fanon’S True Opinion On Violence, Caroline D. Renko

The Downtown Review

In an attempt to clear Frantz Fanon’s name, on account of his opinion on the role of violence in decolonizing a nation, this paper focuses on two important chapters in his last book, The Wretched of the Earth. By closely reading his articulation of the Algerian war and the wounds brought on by mental illness at such a time, Fanon’s true opinion concerning violence becomes clear. For too long, he has been seen and used as a proponent for inciting violence, but this is a misconception that has been perpetuated by devaluing the importance of his descriptions of ...


Career Regret Among Physician Assistants: A Comparative Survey Of Primary And Specialty Care Careers, Talia Sierra, Jennifer Forbes, Michael Nelson Dec 2018

Career Regret Among Physician Assistants: A Comparative Survey Of Primary And Specialty Care Careers, Talia Sierra, Jennifer Forbes, Michael Nelson

Internet Journal of Allied Health Sciences and Practice

Purpose: This study investigated if career regret varies among physician assistants (PAs) practicing in primary and specialty care fields. This information may assist practicing and aspiring physician assistants when selecting or changing their career path.

Methods: A survey was emailed to 5,000 primary and specialty care physician assistants. Items indicating career regret were compared between primary and specialty care groups.

Results: Eight hundred and thrity-four (16.7%) completed surveys were received back. Career regret is similar between primary and specialty care physician assistants, with low reports from both groups. No statistical significance was found between primary care and specialty ...


Epidemiology Of Equestrian Accidents: A Literature Review, Lauren Meredith, Robert Ekman, Karin Brolin Dec 2018

Epidemiology Of Equestrian Accidents: A Literature Review, Lauren Meredith, Robert Ekman, Karin Brolin

Internet Journal of Allied Health Sciences and Practice

Purpose: This manuscript aimed to present a review of the literature pertaining to horse riding and other horse-related injuries.

Method: A review of the literature was performed, searching for appropriate terms with regards to horse accidents, horse riding injuries and protective clothing for the horse riding context. The literature review search returned 151 relevant full-text articles, with 71 of these detailing the overall injury epidemiology of horse-related accidents. Most of these studies were conducted in the USA and used a retrospective review of hospital data methodology.

Results: Of the 71 articles investigated, 60 suggested that those most frequently involved in ...


Effect Of Mental And Physical Practice On Clinical Skill Learning In Kinesiology, Melanie E. Perreault, Christopher Brown, Robert J. Doan, David R. Dolbow Dec 2018

Effect Of Mental And Physical Practice On Clinical Skill Learning In Kinesiology, Melanie E. Perreault, Christopher Brown, Robert J. Doan, David R. Dolbow

Internet Journal of Allied Health Sciences and Practice

Purpose: The amount of information required for an allied health professional has increased dramatically. In-class practice time and large amounts of practice materials may be difficult for instructors to acquire. Mental practice is a method of practice that does not involve physical movement or materials. This study investigated the effect of mental practice, physical practice, and a combination of mental and physical practice on kinesiology students learning three manual muscle tests.

Method: Fifty-six students aged 18 to 26 years (M = 20.09, SD + 1.58), pursuing a degree in kinesiology with an emphasis in either athletic training or kinesiotherapy participated ...


Effects Of Pre-Workout Supplements On Strength, Endurance, And Mood, Anya C. Ellerbroek, Jose Antonio Dec 2018

Effects Of Pre-Workout Supplements On Strength, Endurance, And Mood, Anya C. Ellerbroek, Jose Antonio

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this pilot study was to assess the acute effects of consuming pre-workout supplements on indices of muscular strength, endurance and mood states.

Methods: In a double- blind, placebo-controlled, randomized crossover design, fourteen moderate to highly-trained recreational athletes (7 female, 7 male) participated in this investigation. Subjects came to the lab twice between testing sessions. They consumed either pre supplement (mixed with 8 to 12 ounces of water) or placebo 30-minutes prior to testing. The pre-workout supplement combination (Athelite Nutrition Inc.) contained 15.62 grams per serving, 25 kcals, that consisted of a proprietary blend including caffeine ...


Setting Research Priorities Within Allied Health: What Do Clinicians Think?, Annette Davis, Den-Ching Angel Lee, Lisa-Anabell Wenzel, Terry Haines Dec 2018

Setting Research Priorities Within Allied Health: What Do Clinicians Think?, Annette Davis, Den-Ching Angel Lee, Lisa-Anabell Wenzel, Terry Haines

Internet Journal of Allied Health Sciences and Practice

Background: Research activity among allied health clinicians working in publicly funded health care organisations is growing, yet little attention has been paid to how these activities are prioritised. Without a specific framework to guide research direction, it is likely that research will be conducted in areas that are prioritised by individual clinicians. However, it is presently unknown what areas are prioritised by clinicians and the reasoning behind their prioritisation. Purpose: The aims of this study were to identify what clinicians identify to be the highest priority research across personal, department, and health service levels, and the reasons why. It also ...


Need For Nutrition Education In Health Professional Programs: A Review Of The Literature, Nava Livne 5330719 Dec 2018

Need For Nutrition Education In Health Professional Programs: A Review Of The Literature, Nava Livne 5330719

Internet Journal of Allied Health Sciences and Practice

Purpose: The ever-increasing burden of obesity as a high risk factor for nutrition-related diseases, together with health professionals’ lack of competencies in nutrition, has left health professional students needing further education to offer nutrition advising to patients. The purpose of this review was to summarize the current literature related to nutrition education in health professional programs.

Method: This literature review was conducted using eight scientific literature databases: PubMed, CINAHL Complete, PsycINFO, Academic Search Complete, Directory of Open Access Journals, Professional Development Collection, Complementary Index, and Google Scholar. Articles published in English from January 2007 through January 2018 were reviewed. Keywords ...


Creating Significant Learning Experiences For Clinical Reasoning By Physical Therapist Students, Lois A. Stickley Dec 2018

Creating Significant Learning Experiences For Clinical Reasoning By Physical Therapist Students, Lois A. Stickley

Internet Journal of Allied Health Sciences and Practice

Background: Clinical reasoning skills are embedded in all aspects of practice. There is a lack of consensus and standards for curriculum design and teaching methods of clinical reasoning in entry-level education of health professionals. Purpose: The purpose was to describe a process of designing one comprehensive, planned sequence of four courses to create significant learning experiences for clinical reasoning for Doctor of Physical Therapy students. Method: Fink’s design process was used to develop four clinical decision-making courses to ensure a close alignment of learning goals, feedback and assessment, and learning activities to engage students in practicing components of clinical ...


Use Of The Kawa Model To Facilitate Interprofessional Collaboration: A Pilot Study, Jennifer E. Lape, Ashley Lukose, Diana R.M. Ritter, Brian D. Scaife Dec 2018

Use Of The Kawa Model To Facilitate Interprofessional Collaboration: A Pilot Study, Jennifer E. Lape, Ashley Lukose, Diana R.M. Ritter, Brian D. Scaife

Internet Journal of Allied Health Sciences and Practice

Purpose: The Kawa (river in Japanese) model uses the metaphor of a river to view one’s life from a metaphysical perspective, with consideration given to the interaction between social and physical environments, life circumstances, assets, and liabilities. Preliminary research suggests that the Kawa model may be an effective tool for interprofessional collaboration, but studies employing the model with diverse groups of healthcare professionals have not been undertaken. The purpose of this pilot study was to determine if the Kawa model could serve as an effective collaboration tool for a diverse healthcare team within a skilled nursing facility.

Method: A ...


Inside Outsourcing: Experiences Of Outsourced Physical Therapy Services In Dutch Hospitals, Rudi A. Steenbruggen Pt, Mba, Hannah Boven Msc Dec 2018

Inside Outsourcing: Experiences Of Outsourced Physical Therapy Services In Dutch Hospitals, Rudi A. Steenbruggen Pt, Mba, Hannah Boven Msc

Internet Journal of Allied Health Sciences and Practice

Over the past years, it has become more common in Dutch hospitals to outsource allied healthcare services to the private sector. This development has affected hospital-based physical therapy significantly. And as a result, there is an increasing need for guidance in this new situation. In response to this, the Dutch Association of Physical Therapy in Hospitals (NVZF) conducted a comprehensive study into the process of outsourcing with the objective to inform and advise physical therapy services in hospitals about outsourcing developments. Eight Dutch hospitals where physical therapy services had been outsourced or where this option was explored, were interviewed. The ...


Physical Therapy Faculty, Clinical Instructors, And Employer Expectations For New Dpt Graduates In The Acute Care Setting, Leah Nof, Claudia Gazsi, Shari Rone-Adams, Debra F. Stern Dec 2018

Physical Therapy Faculty, Clinical Instructors, And Employer Expectations For New Dpt Graduates In The Acute Care Setting, Leah Nof, Claudia Gazsi, Shari Rone-Adams, Debra F. Stern

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to determine how the expectations of new graduate physical therapists held by physical therapy faculty (PTF), clinical instructors (CIs), and employers (PTE) compared in the acute care (AC) setting, and determine if graduates are meeting the entry-level expectations of the three stakeholders in acute care. Methods: This mixed method study used Survey Monkey to gather data from participants. Faculty, CIs and PTEs were recruited from CAPTE accredited DPT programs. The current survey used the top 25 characteristics developed by the Delphi study by Gazsi to determine level of agreement of importance among the ...


Using Picture-Story Books To Help Families Understand Turbulent Parental Emotions In Families With Small Children, Anne Sved Williams, Marie Jonsson-Harrison Dec 2018

Using Picture-Story Books To Help Families Understand Turbulent Parental Emotions In Families With Small Children, Anne Sved Williams, Marie Jonsson-Harrison

Journal of Parent and Family Mental Health

A parent’s struggle to manage their emotions may have significant impact on small children. Helping a child understand in the here and now about what is going on for the parent, without blaming that parent or the child, may be useful for the child. It may also lead the child to seek different models of managing emotions and self-concepts. Reading books with children, or bibliotherapy, could be useful for parents who experience stress-related “meltdowns” or perhaps live with mental health conditions such as borderline personality disorder, and for those working with small children in educational, child care or child ...


One-Sentence, One-Word: An Innovative Data Collection Method To Enhance Exploration Of The Lived Experiences, Shannon L. Sibbald, Dylan Brennan, Aleksandra Zecevic Dec 2018

One-Sentence, One-Word: An Innovative Data Collection Method To Enhance Exploration Of The Lived Experiences, Shannon L. Sibbald, Dylan Brennan, Aleksandra Zecevic

The Qualitative Report

Experienced-based methods are growing in popularity and are increasingly being utilized in a variety of research programs and investigations. They enable researchers and participants to co-design research strategies and outcomes and subsequently propose solutions to potential problems in the partnership. By applying an experience-based methods lens, we sought to augment traditional qualitative interviewing methodologies by using a novel method we named “one-sentence, one-word” (1S1W). To apply our 1S1W method, we used a phenomenological study that examined the relationship between the risk of falling and the desire of master athletes to engage in competitive sports. Participants reflected and recorded their subjective ...


Applying The Theory Of Planned Behavior To Sedentariness And Stress, Shana M. Walsh, M. Renée Umstattd Meyer, Grant B. Morgan, Rodney G. Bowden, Eva Doyle, Paul M. Gordon Dec 2018

Applying The Theory Of Planned Behavior To Sedentariness And Stress, Shana M. Walsh, M. Renée Umstattd Meyer, Grant B. Morgan, Rodney G. Bowden, Eva Doyle, Paul M. Gordon

Health Behavior Research

Objective: The purpose of this study was to evaluate the predictive value of the theory of planned behavior (TPB) in the sedentary behavior (SB) of young and middle-aged U.S. adults. Relationships between SB over a six-week period were examined using socio-demographic characteristics, TPB constructs, and a stress variable.

Methods: Participants (n=45, mean age=31 years, 70% female, 83% White) completed surveys that included sociodemographic information, TPB constructs, and the Weekly Stress Inventory. Participants wore an activity monitor for six weeks and completed the stress inventory once weekly over the study period. A longitudinal model was estimated to determine ...


A Public Health Argument Against Arming Teachers, David I. Swedler Dec 2018

A Public Health Argument Against Arming Teachers, David I. Swedler

Health Behavior Research

The peer-reviewed scientific literature does not support the idea that arming teachers will prevent school shootings. In this commentary, I draw on the criminal justice, injury prevention, and firearm safety literature to demonstrate how arming teachers will do more harm than good.


Elaia 2018, Stephen Case Dec 2018

Elaia 2018, Stephen Case

ELAIA

Over the years, the Program has continued to grow and flourish, and the depth of its research continues to increase. This inaugural journal represents the fruits of that development, containing capstone research projects from the 2018 Honors Program senior class and their faculty mentors. The Table of Contents is diverse, and in that way it is a crystal clear reflection of our program’s community of scholars.

I, along with the members of the Honors Council, am gratified by the work of each student and faculty mentor printed within these pages. Congratulations, everyone!

- Stephen Lowe, Honors Program Director


A Multicase Study Exploring Women’S Narratives Of Infertility: Implications For Counselors, Staci L. Born, Christin L. Carotta, Kristine Ramsay-Seaner Dec 2018

A Multicase Study Exploring Women’S Narratives Of Infertility: Implications For Counselors, Staci L. Born, Christin L. Carotta, Kristine Ramsay-Seaner

The Qualitative Report

Infertility affects 6.7 million women in the United States (Chandra, Copen, & Stephen, 2013). Women’s experiences with infertility are not only influenced by biological health factors, but also by social, cultural, and personal variables. Given the prevalence and complexity of infertility, additional research is needed to further examine the nuances of women’s experiences. The purpose of this multicase study, as informed by four individual cases, was to explore how women construct their infertility narratives. Review of reflective journals found five common elements: (1) Emotional Rollercoaster, (2) Mind-Body (Dis)Connection, (3) Secret Identity, (4) Supportive vs. Constrained Communication Patterns ...


Ultrasound Use In Resource-Limited Settings: A Systematic Review, Ravindra Gopaul, Gonzalo Bearman, Michael P. Stevens Dec 2018

Ultrasound Use In Resource-Limited Settings: A Systematic Review, Ravindra Gopaul, Gonzalo Bearman, Michael P. Stevens

Journal of Global Radiology

Purpose: Over the past decade, ultrasound (US) machines have become smaller, less expensive, more reliable, durable and user-friendly, making ultrasonography an ideal imaging modality in resource-poor settings. We conducted a literature review to examine the use of ultrasound in resource-limited settings, with emphasis on common applications, barriers to implementation, and impact on clinical decision-making and patient disposition.

Methods and Materials: Literature review. We conducted a PubMed and Cochrane Central search on the clinical use of ultrasound in the developing world. Search terms included ultrasonography, developing countries, resource limited, remote setting, poverty, and low income. Articles from 2000 to 2015 that ...


Occupational Therapy: A Partner For Justice In Jesuit Higher Education, Rebecca M. Aldrich Dec 2018

Occupational Therapy: A Partner For Justice In Jesuit Higher Education, Rebecca M. Aldrich

Jesuit Higher Education: A Journal

The commitment to justice spans disciplines across Jesuit higher education, including the health sciences. At least 12 Jesuit colleges and universities offer occupational therapy programs, but the profession has been somewhat overlooked as a partner for justice on those campuses. Through a case example focusing on Saint Louis University’s Department of Occupational Science and Occupational Therapy (SLU-DOSOT), this article aims to illustrate the ways in which occupational therapy can be a partner in the promotion and pursuit of justice. A brief overview of the profession’s perspective on occupational justice precedes the description of SLU-DOSOT, and selected examples illustrate ...


Introducing E-Consents In A Clinical Setting, Jesse Weiss, Donna A. Santillan, Kellie Thomas, Heather Davis, Mark K. Santillan, Debra Sue Brandt Dec 2018

Introducing E-Consents In A Clinical Setting, Jesse Weiss, Donna A. Santillan, Kellie Thomas, Heather Davis, Mark K. Santillan, Debra Sue Brandt

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is a multiorgan hypertensive-disorder in pregnancy that causes significant maternal-fetal mortality and morbidity. The diagnostics and therapeutics for PE are limited due to its unclear etiology. Using the UI Maternal Fetal Tissue Bank, our lab has demonstrated that copeptin is robustly predictive of PE. To investigate copeptin further, we developed the Rule Out Pre-Eclampsia Study (ROPE). The ROPE study recruits women admitted to Labor and Delivery for evaluation of PE. Women are admitted for PE evaluation at all hours. Research team members are not available at all times to obtain consent which limits recruitment. Our project aimed to ...


Betamethasone: A Novel Therapeutic Intervention For Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan Dec 2018

Betamethasone: A Novel Therapeutic Intervention For Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

The early pathogenesis of preeclampsia (PE) involves a systemic inflammatory immune response. Recent data demonstrate that increased circulating arginine vasopressin (AVP) in humans is predictive of PE and that infusion of AVP in mouse dams phenocopies the pregnancy-specific cardiovascular and immune alterations observed in human PE. Specifically, AVP suppresses anti-inflammatory cytokines and cells. Betamethasone (BMTZ), commonly given to women at risk for preterm birth, is both an AVP and immune response modulator. We hypothesize that early treatment with BMTZ will prevent the development of AVP-induced PE.


Static Urine Osmolality With Elevated First Trimester Urine Copeptin In Human Preeclampsia, Donna A. Santillan, Sabrina M. Scroggins, Alyssa T. Ray, Shao Y. Zhang, Curt D. Sigmund, Gary L. Pierce, Justin L. Grobe, Mark K. Santillan Dec 2018

Static Urine Osmolality With Elevated First Trimester Urine Copeptin In Human Preeclampsia, Donna A. Santillan, Sabrina M. Scroggins, Alyssa T. Ray, Shao Y. Zhang, Curt D. Sigmund, Gary L. Pierce, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

We have previously shown that maternal plasma copeptin (CPP), as a marker of vasopressin, is highly predictive of preeclampsia (PE) in the first trimester and remains elevated throughout pregnancy. Furthermore, in maternal urine samples we demonstrated that CPP was also significantly elevated in the first trimester in women who later developed PE. Because a urine dipstick test could be easily used in the clinic, we sought to validate this finding in a new and expanded cohort of samples and to determine whether these changes persist throughout pregnancy. In addition, to begin to address the mechanism for this difference, we also ...


Good News About Women & Hpv By Alexander Mortakis Md, Phd, Colleen Stockdale Dec 2018

Good News About Women & Hpv By Alexander Mortakis Md, Phd, Colleen Stockdale

Proceedings in Obstetrics and Gynecology

Dr. Mortakis is recognized internationally as an expert in HPV infections and lower genital tract diseases. ‘Good News About Women & HPV’ was written to provide an accurate and informational resource for his many patients who are concerned about HPV infections and their health. This book is a practical, hands-on approach for women as well as their partners. In addition to well organized chapters (starting with definitions and an introduction to the HPV virus), he poses and answers over 300 questions. The format is straight forward and presents information using both medical terms and lay definitions to assist the reader in ...


Developing A Program For Residents To Support Training In Research, Donna Santillan, Michaela Wiltgen, Marygrace Elson, Mark K. Santillan Dec 2018

Developing A Program For Residents To Support Training In Research, Donna Santillan, Michaela Wiltgen, Marygrace Elson, Mark K. Santillan

POG In Press

Physicians are expected to be life-long learners and to assimilate and evaluate new knowledge gained from research. Many residencies also require completion of a scholarly project during their residency. However, the majority of residency training is dedicated to enhancing clinical knowledge base and skills. Often, residents are not provided with a structured learning experience and support system for research.


Vestibular Schwannoma Growth During Pregnancy: Case Report Of Neurofibromatosis Type 2 In Pregnancy, Sraavya S. Akella, Jordan N. Mattson, Nina N. Moreira Md Dec 2018

Vestibular Schwannoma Growth During Pregnancy: Case Report Of Neurofibromatosis Type 2 In Pregnancy, Sraavya S. Akella, Jordan N. Mattson, Nina N. Moreira Md

POG In Press

Background: Acoustic neuromas are a common sequela of neurofibromatosis type 2 and have been shown to grow at an increased rate during pregnancy.

Case: 21-year-old female, gravida 1 para 0, with history of neurofibromatosis type 2 presented for prenatal care following new onset seizures and progressive deafness. She was found to have bilateral slow-growing acoustic neuromas. Over the course of her pregnancy, her acoustic neuroma began growing and she became completely deaf. She underwent surgical decompression during her pregnancy and had a late preterm vaginal delivery due to preeclampsia with severe features. She subsequently had further operative and medical treatment ...


First Trimester Elevation In Circulating Endothelin-1 And Arterial Stiffness Are Predictive Of Late Pregnancy Preeclampsia, Alexandria M. Betz, Gary L. Pierce, Donna A. Santillan, Eric J. Devor, Sabrina M. Scroggins, Debra S. Brandt, Amy K. Stroud, Kellie M. Thomas, Seth W. Holwerda, Allison O’Deen, Lyndsey E. Dubose, Justin L. Grobe, Curt D. Sigmund, Mark K. Santillan Dec 2018

First Trimester Elevation In Circulating Endothelin-1 And Arterial Stiffness Are Predictive Of Late Pregnancy Preeclampsia, Alexandria M. Betz, Gary L. Pierce, Donna A. Santillan, Eric J. Devor, Sabrina M. Scroggins, Debra S. Brandt, Amy K. Stroud, Kellie M. Thomas, Seth W. Holwerda, Allison O’Deen, Lyndsey E. Dubose, Justin L. Grobe, Curt D. Sigmund, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is characterized by late pregnancy hypertension and proteinuria. PE causes significant morbidity for the maternal-fetal unit. Circulating endothelin-1 (ET-1), a potent vasoconstrictor, is elevated at the time of diagnosis of human PE. In addition, women with PE demonstrate arterial stiffness as early as the end of the first trimester. However, it is unknown if arterial stiffness is associated with a first trimester elevation in ET-1 and post-delivery placental ET-1. We hypothesized that 1) first trimester plasma ET-1 is elevated and is associated with arterial stiffness in women who develop PE; 2) first trimester ET-1 is predictive of PE ...


Identifying Risk Factors For Preeclampsia In Subsequent Pregnancies In Women With A History Of Preeclampsia, Michaela Wiltgen, Donna A. Santillan, Kellie Thomas, Adam Fitzsimmons, Lindsay Krotz, Heather Davis, Laura Jacobus, Mark K. Santillan, Debra S. Brandt Dec 2018

Identifying Risk Factors For Preeclampsia In Subsequent Pregnancies In Women With A History Of Preeclampsia, Michaela Wiltgen, Donna A. Santillan, Kellie Thomas, Adam Fitzsimmons, Lindsay Krotz, Heather Davis, Laura Jacobus, Mark K. Santillan, Debra S. Brandt

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is a prevalent hypertensive disorder of pregnancy that causes significant maternal-fetal mortality. It has been reported that 60% of maternal mortality can be prevented. Studies have demonstrated that nursing has the ability to influence the mortality rates by providing proactive and competent care. Part of proactive, competent care is to identify those women at the highest risk for PE. Multiple studies have identified a history of PE as a significant risk factor for PE in future gestations. We conducted a nested case control study with our Rule Out Pre-Eclampsia (ROPE) cohort to identify comorbidities most likely to lead ...