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Full-Text Articles in Medicine and Health Sciences

Effects Of The Covid-19 Pandemic On Medical Students: A Multicenter Quantitative Study, A. J. Harries, C. Lee, L. Jones, R. M. Rodriguez, J. A. Davis, M. Boysen-Osborn, K. J. Kashima, N. K. Krane, J. M. Langsfeld, M. Juarez, +2 Additional Authors Jan 2021

Effects Of The Covid-19 Pandemic On Medical Students: A Multicenter Quantitative Study, A. J. Harries, C. Lee, L. Jones, R. M. Rodriguez, J. A. Davis, M. Boysen-Osborn, K. J. Kashima, N. K. Krane, J. M. Langsfeld, M. Juarez, +2 Additional Authors

Journal Articles

© 2021, The Author(s). Background: The COVID-19 pandemic disrupted the United States (US) medical education system with the necessary, yet unprecedented Association of American Medical Colleges (AAMC) national recommendation to pause all student clinical rotations with in-person patient care. This study is a quantitative analysis investigating the educational and psychological effects of the pandemic on US medical students and their reactions to the AAMC recommendation in order to inform medical education policy. Methods: The authors sent a cross-sectional survey via email to medical students in their clinical training years at six medical schools during the initial peak phase of the ...


Brief Communication: A Radiology Resident's Experience With Covid-19 In New York City, A. Ramjit, A. Gokli Jan 2021

Brief Communication: A Radiology Resident's Experience With Covid-19 In New York City, A. Ramjit, A. Gokli

Journal Articles

© 2020 Elsevier Inc. The COVID-19 pandemic impacted New York City severely. As a radiology resident, I was unsure how my role would change as the pandemic unfolded. Like many hospital systems in New York City, my department was asked to assist in the clinical care of patients during the dramatic surge of admissions related to COVID-19. I placed invasive central lines for critically ill patients in the intensive care unit to help reduce the workload on already overwhelmed critical care teams. I also performed direct patient care within dedicated COVID-19 inpatient floors.


The Impact Of Confirmed Coronavirus Disease 2019 (Covid-19) Infection On Ambulatory Procedures And Associated Delays In Care For Asymptomatic Patients, C. G. Larsen, C. D. Bub, B. C. Schaffler, T. Walden, J. M. Intravia Jan 2021

The Impact Of Confirmed Coronavirus Disease 2019 (Covid-19) Infection On Ambulatory Procedures And Associated Delays In Care For Asymptomatic Patients, C. G. Larsen, C. D. Bub, B. C. Schaffler, T. Walden, J. M. Intravia

Journal Articles

© 2021 Elsevier Inc. Background: Since the reopening of ambulatory centers, minimal data has been reported regarding positive tests among patients undergoing ambulatory procedures, associated delays in care, and outcomes of patients previously positive for coronavirus disease 2019. Methods: A retrospective observational case series of ambulatory procedures was performed. Records since the reopening of ambulatory centers in New York were searched for patients with positive coronavirus disease 2019 nasal swab results who underwent ambulatory procedures. Chart reviews were conducted to determine coronavirus disease history and hospitalizations, demographic information, procedure details, and 30-day admissions. Results: A total of 3,762 patients underwent ...


The Use Of Oxygen Hoods In Patients Failing On Conventional High-Flow Oxygen Delivery Systems, The Effects On Oxygenation, Mechanical Ventilation And Mortality Rates In Hypoxic Patients With Covid-19. A Prospective Controlled Cohort Study, D. Dayya, O. J. O'Neill, T. D. Feiertag, R. Tuazon-Boer, J. Sullivan, L. Perez, S. Gurash, M. Eaton, T. Bodley, T. Hall, +2 Additional Authors Jan 2021

The Use Of Oxygen Hoods In Patients Failing On Conventional High-Flow Oxygen Delivery Systems, The Effects On Oxygenation, Mechanical Ventilation And Mortality Rates In Hypoxic Patients With Covid-19. A Prospective Controlled Cohort Study, D. Dayya, O. J. O'Neill, T. D. Feiertag, R. Tuazon-Boer, J. Sullivan, L. Perez, S. Gurash, M. Eaton, T. Bodley, T. Hall, +2 Additional Authors

Journal Articles

© 2021 Introduction: Efforts to meet increased oxygen demands in COVID-19 patients are a priority in averting mechanical ventilation (MV), associated with high mortality approaching 76.4–97.2%. Novel methods of oxygen delivery could mitigate that risk. Oxygen hoods/helmets may improve: O2-saturation (SaO2), reduce in-hospital mechanical ventilation and mortality rates, and reduce length of hospitalization in hypoxic Covid-19 patients failing on conventional high-flow oxygen delivery systems. Methods: DesignProspective Controlled Cohort Study. SettingSingle Center. ParticipantsAll patients admitted with a diagnosis of COVID-19 were reviewed and 136/347 patients met inclusion criteria. Study period3/6/2020 to 5/1/2020. 136 ...


Utilization Of Extracorporeal Membrane Oxygenation During The Covid-19 Pandemic., A. Kichloo, A. Kumar, R. Amir, M. Aljadah, N. Farooqi, M. Albosta, J. Singh, S. Jamal, Z. El-Amir, N. Lone, +1 Additional Author Jan 2021

Utilization Of Extracorporeal Membrane Oxygenation During The Covid-19 Pandemic., A. Kichloo, A. Kumar, R. Amir, M. Aljadah, N. Farooqi, M. Albosta, J. Singh, S. Jamal, Z. El-Amir, N. Lone, +1 Additional Author

Journal Articles

The ongoing outbreak of severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2, or coronavirus disease 2019 (COVID-19)] was declared a pandemic by the World Health Organization on March 11, 2020. Worldwide, more than 65 million people have been infected with this SARS-CoV-2 virus, and over 1.5 million people have died due to the viral illness. Although a tremendous amount of medical progress has been made since its inception, there continues to be ongoing research regarding the pathophysiology, treatments, and vaccines. While a vast majority of those infected develop only mild to moderate symptoms, about 5% of people have severe forms of ...


A Case-Control Study Of Prone Positioning In Awake And Nonintubated Hospitalized Coronavirus Disease 2019 Patients., P. C. Nauka, S. Chekuri, M. Aboodi, A. A. Hope, M. N. Gong, J.T. Chen Jan 2021

A Case-Control Study Of Prone Positioning In Awake And Nonintubated Hospitalized Coronavirus Disease 2019 Patients., P. C. Nauka, S. Chekuri, M. Aboodi, A. A. Hope, M. N. Gong, J.T. Chen

Journal Articles

To determine the association between prone positioning in nonintubated patients with coronavirus disease 2019 and frequency of invasive mechanical ventilation or inhospital mortality.

Design

A nested case-matched control analysis.

Setting

Three hospital sites in Bronx, NY.

Patients

Adult coronavirus disease 2019 patients admitted between March 1, 2020, and April 1, 2020. We excluded patients with do-not-intubate orders. Cases were defined by invasive mechanical ventilation or inhospital mortality. Each case was matched with two controls based on age, gender, admission date, and hospital length of stay greater than index time of matched case via risk-set sampling. The presence of nonintubated proning ...


Transitioning Trainees From The Operating Room To The Covid-19 Intensive Care Unit In New York – Correspondence, M. A. Catalano, G. F. Coppa, V. M. Patel Jan 2021

Transitioning Trainees From The Operating Room To The Covid-19 Intensive Care Unit In New York – Correspondence, M. A. Catalano, G. F. Coppa, V. M. Patel

Journal Articles

No abstract provided.


The Impact Of Perinatal Severe Acute Respiratory Syndrome Coronavirus 2 Infection During The Peripartum Period., O. Janssen, M. Thompson, S. Milburn, R. Green, B. Wagner, A. Bianco, A. Stroustrup Jan 2021

The Impact Of Perinatal Severe Acute Respiratory Syndrome Coronavirus 2 Infection During The Peripartum Period., O. Janssen, M. Thompson, S. Milburn, R. Green, B. Wagner, A. Bianco, A. Stroustrup

Journal Articles

No abstract provided.


Imaging Algorithm For Covid-19: A Practical Approach, S. Ghosh, H. Deshwal, M. B. Saeedan, V. K. Khanna, S. Raoof, A. C. Mehta Jan 2021

Imaging Algorithm For Covid-19: A Practical Approach, S. Ghosh, H. Deshwal, M. B. Saeedan, V. K. Khanna, S. Raoof, A. C. Mehta

Journal Articles

© 2020 Elsevier Inc. The global pandemic of COVID-19 pneumonia caused by the novel coronavirus (SARS-CoV-2) has strained healthcare resources across the world with emerging challenges of mass testing, resource allocation and management. While reverse transcriptase-polymerase chain reaction (RT-PCR) test is the most commonly utilized test and considered the current gold standard for diagnosis, the role of chest imaging has been highlighted by several studies demonstrating high sensitivity of computed tomography (CT). Many have suggested using CT chest as a first-line screening tool for the diagnosis of COVID-19. However, with advancement of laboratory testing and challenges in obtaining a CT scan ...


Ethnic Differences In Thromboprophylaxis For Covid-19 Patients: Should They Be Considered?, T. Iba, J. M. Connors, A. C. Spyropoulos, H. Wada, J. H. Levy Jan 2021

Ethnic Differences In Thromboprophylaxis For Covid-19 Patients: Should They Be Considered?, T. Iba, J. M. Connors, A. C. Spyropoulos, H. Wada, J. H. Levy

Journal Articles

© 2021, Japanese Society of Hematology. Thromboembolic events contribute to morbidity and mortality in coronavirus disease 2019 (COVID-19). As a result, thromboprophylaxis using low-molecular-weight heparin (LMWH) is universally recommended for hospitalized patients based on multiple guidelines. However, ethnic differences with respect to thrombogenicity have been reported and the incidence of thromboembolic events is considered to be lower in the Asian population. Despite the importance of thromboprophylaxis, bleeding is also a side effect that should be considered. We examine the data relating to potential ethnic differences in thrombosis and bleeding in COVID-19. Although sufficient data is not yet available, current evidence does ...


Association Between Regional Distributions Of Sars-Cov-2 Seroconversion And Out-Of-Hospital Sudden Death During The First Epidemic Outbreak In New York., K. M. Coleman, M. Saleh, S. E. Mountantonakis Jan 2021

Association Between Regional Distributions Of Sars-Cov-2 Seroconversion And Out-Of-Hospital Sudden Death During The First Epidemic Outbreak In New York., K. M. Coleman, M. Saleh, S. E. Mountantonakis

Journal Articles

Background

Increased incidence of out-of-hospital sudden death (OHSD) has been reported during the coronavirus 2019 (COVID-19) pandemic. New York City (NYC) represents a unique opportunity to examine the epidemiologic association between the two given the variable regional distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in its highly diverse neighborhoods.

Objective

The purpose of this study was to examine the association between OHSD and SARS-CoV-2 epidemiologic burden during the first COVID-19 pandemic across the highly diverse neighborhoods of NYC.

Methods

The incidences of OHSD between March 20 and April 22, 2019, and between March 20 and April 22, 2020 ...


Convalescent Plasma For Covid-19 Complicated By Ards Due To Trali, K. Y. Wang, P. Shah, M. Pierce Jan 2021

Convalescent Plasma For Covid-19 Complicated By Ards Due To Trali, K. Y. Wang, P. Shah, M. Pierce

Journal Articles

© 2021 BMJ Publishing Group. All rights reserved. Convalescent plasma, which contains antibodies from recovered individuals, has been used as an effective treatment for infectious diseases in the past and is currently being used as a potential treatment option for COVID-19. Multiple studies have reported this treatment to be safe. We report a case of a patient who developed acute respiratory distress syndrome (ARDS) with features suggestive of transfusion-related acute lung injury after being treated with convalescent plasma for COVID-19. We emphasise the need to be aware of the potential risk of transfusion reactions and disease worsening with convalescent plasma administration ...


Atrial Fibrillation Is An Independent Predictor For In-Hospital Mortality In Patients Admitted With Sars-Cov-2 Infection., S. E. Mountantonakis, M. Saleh, J. Fishbein, A. Gandomi, M. Lesser, J. Chelico, J. Gabriels, M. Qiu, L. M. Epstein, Northwell Covid-19 Research Consortium Jan 2021

Atrial Fibrillation Is An Independent Predictor For In-Hospital Mortality In Patients Admitted With Sars-Cov-2 Infection., S. E. Mountantonakis, M. Saleh, J. Fishbein, A. Gandomi, M. Lesser, J. Chelico, J. Gabriels, M. Qiu, L. M. Epstein, Northwell Covid-19 Research Consortium

Journal Articles

Background

Atrial fibrillation (AF) is the most encountered arrhythmia and has been associated with worse in-hospital outcomes.

Objective

This study was to determine the incidence of AF in patients hospitalized with coronavirus disease 2019 (COVID-19) as well as its impact on in-hospital mortality.

Methods

Patients hospitalized with a positive COVID-19 polymerase chain reaction test between March 1 and April 27, 2020, were identified from the common medical record system of 13 Northwell Health hospitals. Natural language processing search algorithms were used to identify and classify AF. Patients were classified as having AF or not. AF was further classified as new-onset ...


Professionally Responsible Coronavirus Disease 2019 Vaccination Counseling Of Obstetrical And Gynecologic Patients, F. A. Chervenak, L. B. Mccullough, E. Bornstein, L. Johnson, A. Katz, R. Mcleod-Sordjan, M. Nimaroff, B. L. Rochelson, A. Tekbali, A. Warman, K. Williams, A. Grünebaum Jan 2021

Professionally Responsible Coronavirus Disease 2019 Vaccination Counseling Of Obstetrical And Gynecologic Patients, F. A. Chervenak, L. B. Mccullough, E. Bornstein, L. Johnson, A. Katz, R. Mcleod-Sordjan, M. Nimaroff, B. L. Rochelson, A. Tekbali, A. Warman, K. Williams, A. Grünebaum

Journal Articles

© 2021 Elsevier Inc. The development of coronavirus disease 2019 vaccines in the current and planned clinical trials is essential for the success of a public health response. This paper focuses on how physicians should implement the results of these clinical trials when counseling patients who are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed about vaccines with government authorization for clinical use. Determining the most effective approach to counsel patients about coronavirus disease 2019 vaccination is challenging. We address the professionally responsible counseling of 3 groups of patients—those who are pregnant, those planning to become pregnant, and ...


Should Covid-19 Patients > 75 Years Be Ventilated? An Outcome Study., H. Raheja, N. Chukwuka, C. Agarwal, D. Sharma, A. Munoz-Martinez, J. Fogel, M. Khalid, A. T. Hashmi, S. Ehrlich, G. R. Rojas-Marte, +11 Additional Authors Jan 2021

Should Covid-19 Patients > 75 Years Be Ventilated? An Outcome Study., H. Raheja, N. Chukwuka, C. Agarwal, D. Sharma, A. Munoz-Martinez, J. Fogel, M. Khalid, A. T. Hashmi, S. Ehrlich, G. R. Rojas-Marte, +11 Additional Authors

Journal Articles

Background

Elderly patients with COVID-19 disease are at increased risk for adverse outcomes. Current data regarding disease characteristics and outcomes in this population is limited.

Aim

To delineate the adverse factors associated with outcomes of COVID- 19 patients ≥75 years of age.

Design

Retrospective cohort study.

Methods

Patients were classified into mild/moderate, severe/very severe, and critical disease (intubated) based on oxygen requirements. The primary outcome was in-hospital mortality.

Results

355 patients aged ≥75 years hospitalized with COVID-19 between March 19th and April 25th, 2020 were included. Mean age was 84.3 years. One-third of the patients developed critical ...


Anesthetic Considerations In A Patient With Lvad And Covid-19 Undergoing Video-Assisted Thoracic Surgery, R. R. Sikachi, D. Anca Jan 2021

Anesthetic Considerations In A Patient With Lvad And Covid-19 Undergoing Video-Assisted Thoracic Surgery, R. R. Sikachi, D. Anca

Journal Articles

© 2021 Increased survival with left ventricular assist devices (LVAD) has led to a large number of patients with LVADs presenting for noncardiac surgeries (NCS). With studies showing that a trained noncardiac anesthesiologist can safely manage these patients when they present for NCS, it is vital that all anesthesiologists understand the LVAD physiology and its implications in various surgeries. This is even more relevant during the current pandemic in which these complex cardiopulmonary interactions may be even more challenging in patients with coronavirus disease 2019 (COVID-19). The authors describe a case of a patient with COVID-19 with an LVAD who needed ...


Assessing The Importance Of Interleukin-6 In Covid-19 - Authors' Reply., D. E. Leisman, L. Ronner, R. Pinotti, M. D. Taylor, P. Sinha, C. S. Calfee, A. V. Hirayama, F. Mastroianni, C. J. Turtle, C. S. Deutschman, +2 Additional Authors Jan 2021

Assessing The Importance Of Interleukin-6 In Covid-19 - Authors' Reply., D. E. Leisman, L. Ronner, R. Pinotti, M. D. Taylor, P. Sinha, C. S. Calfee, A. V. Hirayama, F. Mastroianni, C. J. Turtle, C. S. Deutschman, +2 Additional Authors

Journal Articles

No abstract provided.


Inclusion Of Pregnant Individuals Among Priority Populations For Coronavirus Disease 2019 Vaccination For All 50 States In The United States., A. Grünebaum, L. B. Mccullough, A. Litvak, F. A. Chervenak Jan 2021

Inclusion Of Pregnant Individuals Among Priority Populations For Coronavirus Disease 2019 Vaccination For All 50 States In The United States., A. Grünebaum, L. B. Mccullough, A. Litvak, F. A. Chervenak

Journal Articles

No abstract provided.


Outcomes In Patients With Covid-19 Disease And High Oxygen Requirements., G. Rojas-Marte, A. T. Hashmi, M. Khalid, N. Chukwuka, J. Fogel, A. Munoz-Martinez, S. Ehrlich, M. Akbar Waheed, D. Sharma, J. Shani, +6 Additional Authors Jan 2021

Outcomes In Patients With Covid-19 Disease And High Oxygen Requirements., G. Rojas-Marte, A. T. Hashmi, M. Khalid, N. Chukwuka, J. Fogel, A. Munoz-Martinez, S. Ehrlich, M. Akbar Waheed, D. Sharma, J. Shani, +6 Additional Authors

Journal Articles

Background

Approximately 19% of people infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progress to severe or critical stages of the coronavirus disease 2019 (COVID-19) with a mortality rate exceeding 50%. We aimed to examine the characteristics, mortality rates, intubation rate, and length of stay (LOS) of patients hospitalized with COVID-19 disease with high oxygen requirements (critically ill).

Methods

We conducted a retrospective analysis in a single center in Brooklyn, New York. Adult hospitalized patients with confirmed COVID-19 disease and high oxygen requirements were included. We performed multivariate logistic regression analyses for statistically significant variables to reduce any ...


Physical Therapy For Hospitalized Covid-19 Patients In Isolation: Feasibility And Pilot Implementation Of Telehealth For Delivering Individualized Therapy., M. Turcinovic, R. Singson, M. Harrigan, S. Ardito, A. Ilyas, L. Sinvani, N. Hajizadeh, E. Burns Jan 2021

Physical Therapy For Hospitalized Covid-19 Patients In Isolation: Feasibility And Pilot Implementation Of Telehealth For Delivering Individualized Therapy., M. Turcinovic, R. Singson, M. Harrigan, S. Ardito, A. Ilyas, L. Sinvani, N. Hajizadeh, E. Burns

Journal Articles

Objective

To optimize the ability of hospitalized patients isolated due to COVID-19 to participate in physical therapy.

Design

This was a prospective, quality improvement trial of the feasibility and acceptability of a "hybrid" in-person and telerehabilitation platform to deliver physical therapy to hospitalized adults.

Setting

Inpatient wards of a tertiary care, multi-specialty academic medical center in the greater New York City metropolitan area.

Participants

A convenience sample of 39 COVID-19+ adults, mean age 57.3 years, 69% male, all previously community dwelling agreed to participate in a combination of in-person and telerehabilitation sessions (TR).

Intervention

Initial in-person evaluation by physical ...


Commentary: Covid 19: Don't Throw Caution To The Wind Nor Air Leak. Use Ppe!, R. S. Lazzaro, M. L. Inra, B. Patton Jan 2021

Commentary: Covid 19: Don't Throw Caution To The Wind Nor Air Leak. Use Ppe!, R. S. Lazzaro, M. L. Inra, B. Patton

Journal Articles

No abstract provided.


Rationale And Design For The Study Of Rivaroxaban To Reduce Thrombotic Events, Hospitalization And Death In Outpatients With Covid-19: The Prevent-Hd Study, W. H. Capell, E. S. Barnathan, G. Piazza, A. C. Spyropoulos, J. Hsia, S. Bull, C. Lipardi, C. Sugarmann, E. Suh, M. P. Bonaca, +2 Additional Authors Jan 2021

Rationale And Design For The Study Of Rivaroxaban To Reduce Thrombotic Events, Hospitalization And Death In Outpatients With Covid-19: The Prevent-Hd Study, W. H. Capell, E. S. Barnathan, G. Piazza, A. C. Spyropoulos, J. Hsia, S. Bull, C. Lipardi, C. Sugarmann, E. Suh, M. P. Bonaca, +2 Additional Authors

Journal Articles

© 2021 Elsevier Inc. Background: COVID-19 is associated with both venous and arterial thrombotic complications. While prophylactic anticoagulation is now widely recommended for hospitalized patients with COVID-19, the effectiveness and safety of thromboprophylaxis in outpatients with COVID-19 has not been established. Study Design: PREVENT-HD is a double-blind, placebo-controlled, pragmatic, event-driven phase 3 trial to evaluate the efficacy and safety of rivaroxaban in symptomatic outpatients with laboratory-confirmed COVID-19 at risk for thrombotic events, hospitalization, and death. Several challenges posed by the pandemic have necessitated innovative approaches to clinical trial design, start-up, and conduct. Participants are randomized in a 1:1 ratio, stratified ...


Coronavirus Neurosurgical/Head And Neck Drape To Prevent Aerosolization Of Coronavirus Disease 2019 (Covid-19): The Lenox Hill Hospital/Northwell Health Solution, Rs D'Amico, D Khatri, K Kwan, G Baum, Y Serulle, D Silva, Ml Smith, Ja Ellis, M Levine, R Ortiz, Dj Langer, Ja Boockvar Jan 2020

Coronavirus Neurosurgical/Head And Neck Drape To Prevent Aerosolization Of Coronavirus Disease 2019 (Covid-19): The Lenox Hill Hospital/Northwell Health Solution, Rs D'Amico, D Khatri, K Kwan, G Baum, Y Serulle, D Silva, Ml Smith, Ja Ellis, M Levine, R Ortiz, Dj Langer, Ja Boockvar

Journal Articles

No abstract provided.


How I Do It: High Flow, Non-Invasive Ventilation And Awake (Non-Intubation) Proning In Covid-19 Patients With Respiratory Failure., S Raoof, S Nava, C Carpati, Ns Hill Jan 2020

How I Do It: High Flow, Non-Invasive Ventilation And Awake (Non-Intubation) Proning In Covid-19 Patients With Respiratory Failure., S Raoof, S Nava, C Carpati, Ns Hill

Journal Articles

No abstract provided.


Public Knowledge And Attitudes Towards Bystander Cardiopulmonary Resuscitation (Cpr) In Ghana, West Africa., M. Anto-Ocrah, N. Maxwell, J. Cushman, E. Acheampong, R. Kodam, C. Homan, T. Li Jan 2020

Public Knowledge And Attitudes Towards Bystander Cardiopulmonary Resuscitation (Cpr) In Ghana, West Africa., M. Anto-Ocrah, N. Maxwell, J. Cushman, E. Acheampong, R. Kodam, C. Homan, T. Li

Journal Articles

BACKGROUND AND OBJECTIVES:Early bystander cardiopulmonary resuscitation (CPR) is one of the most important predictors of out-of-hospital cardiac arrests (OHCA) survival. There is a dearth of literature on CPR engagement in countries such as Ghana, where cardiovascular events are increasingly prevalent. In this study, we sought to evaluate Ghanaians' knowledge of and attitudes towards bystander CPR, in the context of the country's nascent emergency medicine network. METHODS:Capitalizing on the growing ubiquity and use of social media across the country, we used a novel social media sampling strategy for this study. We created, pre-tested, and distributed an online survey ...


A Comparison Of Existing Risk Prediction Models In Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation, B. Worku, M. Gaudino, D. Avgerinos, K. Ramasubbu, I. Gambardella, I. Gulkarov, S. Khin Jan 2020

A Comparison Of Existing Risk Prediction Models In Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation, B. Worku, M. Gaudino, D. Avgerinos, K. Ramasubbu, I. Gambardella, I. Gulkarov, S. Khin

Journal Articles

© 2020 The Author(s) Background: Patients undergoing consideration for venoarterial extracorporeal membrane oxygenation (VA-ECMO) require an immediate risk profile assessment in the setting of incomplete information. A number of survival prediction models for critically ill patients and patients undergoing elective cardiac surgery or institution of VA-ECMO support have been designed. We assess the ability of these models to predict outcomes in a cohort of patients undergoing institution of VA-ECMO for cardiogenic shock or cardiac arrest. Methods: Fifty-one patients undergoing institution of VA-ECMO support were retrospectively analyzed. APACHE II, SOFA, SAPS II, Encourage, SAVE, and ACEF scores were calculated. Their ability ...


Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, X. Shen, S. Ma, P. Vemuri, G. Simon, M. W. Weiner, P. Aisen, R. Petersen, C. R. Jack, P. Davies, V. Shibley, +90 Additional Authors Jan 2020

Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, X. Shen, S. Ma, P. Vemuri, G. Simon, M. W. Weiner, P. Aisen, R. Petersen, C. R. Jack, P. Davies, V. Shibley, +90 Additional Authors

Journal Articles

© 2020, The Author(s). Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the study was to systematically examine whether (i) CSD methods can discover the known causal relationships from observational clinical data and (ii) to offer guidance to accurately discover known causal relationships. We used Alzheimer’s disease (AD), a complex progressive disease, as a model because the well-established evidence provides a “gold-standard” causal graph for evaluation. We ...


Gut Microbiota-Derived Indole 3-Propionic Acid Protects Against Radiation Toxicity Via Retaining Acyl-Coa-Binding Protein, H. W. Xiao, M. Cui, Y. Li, J. L. Dong, S. Q. Zhang, C. C. Zhu, M. Jiang, T. Zhu, H. C. Wang, S. J. Fan, +1 Additional Author Jan 2020

Gut Microbiota-Derived Indole 3-Propionic Acid Protects Against Radiation Toxicity Via Retaining Acyl-Coa-Binding Protein, H. W. Xiao, M. Cui, Y. Li, J. L. Dong, S. Q. Zhang, C. C. Zhu, M. Jiang, T. Zhu, H. C. Wang, S. J. Fan, +1 Additional Author

Journal Articles

© 2020 The Author(s). Background: We have proved fecal microbiota transplantation (FMT) is an efficacious remedy to mitigate acute radiation syndrome (ARS); however, the mechanisms remain incompletely characterized. Here, we aimed to tease apart the gut microbiota-produced metabolites, underpin the therapeutic effects of FMT to radiation injuries, and elucidate the underlying molecular mechanisms. Results: FMT elevated the level of microbial-derived indole 3-propionic acid (IPA) in fecal pellets from irradiated mice. IPA replenishment via oral route attenuated hematopoietic system and gastrointestinal (GI) tract injuries intertwined with radiation exposure without precipitating tumor growth in male and female mice. Specifically, IPA-treated mice represented ...


Outcomes Of Patients With End-Stage Kidney Disease Hospitalized With Covid-19., J. H. Ng, J. S. Hirsch, R. Wanchoo, M. Sachdeva, V. Sakhiya, S. Hong, K. D. Jhaveri, S. Fishbane, Northwell Covid-19 Research Consortium, Northwell Nephrology Covid-19 Research Consortium Jan 2020

Outcomes Of Patients With End-Stage Kidney Disease Hospitalized With Covid-19., J. H. Ng, J. S. Hirsch, R. Wanchoo, M. Sachdeva, V. Sakhiya, S. Hong, K. D. Jhaveri, S. Fishbane, Northwell Covid-19 Research Consortium, Northwell Nephrology Covid-19 Research Consortium

Journal Articles

Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York. hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay), Of 10,482 patients with COVID-19, 419 had ESKD. Patients with ESKD were older, had a greater percentage self-identified as Black ...


Usefulness Of Elevated Troponin To Predict Death In Patients With Covid-19 And Myocardial Injury., D. T. Majure, L. Gruberg, S. G. Saba, C. Kvasnovsky, J. S. Hirsch, R. Jauhar, Northwell Health Covid-19 Research Consortium Jan 2020

Usefulness Of Elevated Troponin To Predict Death In Patients With Covid-19 And Myocardial Injury., D. T. Majure, L. Gruberg, S. G. Saba, C. Kvasnovsky, J. S. Hirsch, R. Jauhar, Northwell Health Covid-19 Research Consortium

Journal Articles

Elevations in troponin levels have been shown to predict mortality in patients with coronavirus disease 2019 (COVID-19). The role of inflammation in myocardial injury remains unclear. We sought to determine the association of elevated troponin with mortality in a large, ethnically diverse population of patients hospitalized with COVID-19, and to determine the association of elevated inflammatory markers with increased troponin levels. We reviewed all patients admitted at our health system with COVID-19 from March 1 to April 27, 2020, who had a troponin assessment within 48 hours of admission. We used logistic regression to calculate odds ratios (ORs) for mortality ...