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2005

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Articles 1 - 30 of 2978

Full-Text Articles in Medicine and Health Sciences

Tobacco Control: Are We Appropriately Training Future Health Professionals, Francisco Soto Mas, Chiehwen Hsu Jan 2012

Tobacco Control: Are We Appropriately Training Future Health Professionals, Francisco Soto Mas, Chiehwen Hsu

Francisco Soto Mas

Information on how health professionals perceive tobacco use as well as their attitudes toward tobacco control is scarce. This study assessed the attitudes and perceptions of public health students toward tobacco use and tobacco control, which constitutes a necessary first step in designing effective training strategies. Although the majority of respondents agreed that tobacco use constitutes a relevant public health problem, they did not perceive tobacco control to be a public health priority. Academic institutions may not be properly training public health students, and may therefore be missing the opportunity to advance tobacco control at the national and global levels.


Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia Sp Dari Kepulauan Seribu, Endang Hanani Dec 2005

Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia Sp Dari Kepulauan Seribu, Endang Hanani

Majalah Ilmu Kefarmasian

Antioxidant activity and identification of antioxidative compounds of Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The sponge was extracted with acetone and the extract was concentrated using rotary vacuum evaporator. DPPH and tiocyanate methods were used to examine the antioxidant activity of the extract. The extract exhibited strong antioxidant activity in DPPH method with IC50 of 41.21 µg/ml. Chemical analysis indicated that the antioxidative compound in the sponge was alkaloid group.


Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, George Q. Daley Dec 2005

Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, George Q. Daley

Dartmouth Scholarship

Despite two decades of studies documenting the in vitro blood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exploited the Cdx-Hox pathway, a genetic program important for blood development, to enhance the differentiation of ESCs along the hematopoietic lineage. Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4 , we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice. Clonal analysis of retroviral integration sites confirms ...


Rapid, Diffusional Shuttling Of Poly(A) Rna Between Nuclear Speckles And The Nucleoplasm, Joan C. Ritland Politz, Richard A. Tuft, Kannanganattu V. Prasanth, Nina Baudendistel, Kevin E. Fogarty, Lawrence M. Lifshitz, Jorg Langowski, David L. Spector, Thoru Pederson Dec 2005

Rapid, Diffusional Shuttling Of Poly(A) Rna Between Nuclear Speckles And The Nucleoplasm, Joan C. Ritland Politz, Richard A. Tuft, Kannanganattu V. Prasanth, Nina Baudendistel, Kevin E. Fogarty, Lawrence M. Lifshitz, Jorg Langowski, David L. Spector, Thoru Pederson

Open Access Publications by UMass Chan Authors

Speckles are nuclear bodies that contain pre-mRNA splicing factors and polyadenylated RNA. Because nuclear poly(A) RNA consists of both mRNA transcripts and nucleus-restricted RNAs, we tested whether poly(A) RNA in speckles is dynamic or rather an immobile, perhaps structural, component. Fluorescein-labeled oligo(dT) was introduced into HeLa cells stably expressing a red fluorescent protein chimera of the splicing factor SC35 and allowed to hybridize. Fluorescence correlation spectroscopy (FCS) showed that the mobility of the tagged poly(A) RNA was virtually identical in both speckles and at random nucleoplasmic sites. This same result was observed in photoactivation-tracking studies in ...


Prevalence Of Overweight In Children And Adolescents With Attention Deficit Hyperactivity Disorder And Autism Spectrum Disorders: A Chart Review, Carol Curtin, Linda G. Bandini, Ellen C. Perrin, David J. Tybor, Aviva Must Dec 2005

Prevalence Of Overweight In Children And Adolescents With Attention Deficit Hyperactivity Disorder And Autism Spectrum Disorders: A Chart Review, Carol Curtin, Linda G. Bandini, Ellen C. Perrin, David J. Tybor, Aviva Must

Open Access Publications by UMass Chan Authors

BACKGROUND: The condition of obesity has become a significant public health problem in the United States. In children and adolescents, the prevalence of overweight has tripled in the last 20 years, with approximately 16.0% of children ages 6-19, and 10.3% of 2-5 year olds being considered overweight. Considerable research is underway to understand obesity in the general pediatric population, however little research is available on the prevalence of obesity in children with developmental disorders. The purpose of our study was to determine the prevalence of overweight among a clinical population of children diagnosed with attention deficit hyperactivity disorder ...


Health Information Access Dec 2005

Health Information Access

The Southeastern Librarian

The National Network of Libraries of Medicine, Southeastern Atlantic Region, wishes to remind libraries in the region that they provide training and assistance with health information access to the public.


A Hybrid Model For Reducing Ecological Bias, Ruth Salway, Jon Wakefield Dec 2005

A Hybrid Model For Reducing Ecological Bias, Ruth Salway, Jon Wakefield

UW Biostatistics Working Paper Series

A major drawback of epidemiological ecological studies, in which the association between area-level summaries of risk and exposure are used to make inference about individual risk, is the difficulty in characterising within-area variability in exposure and confounder variables. To avoid ecological bias, samples of individual exposure/confounder data within each area are required. Unfortunately these may be difficult or expensive to obtain, particularly if large samples are required. In this paper we propose a new approach suitable for use with small samples. We combine a Bayesian non-parametric Dirichlet process prior with an estimating functions approach, and show that this model ...


Public Health Practitioner Expert Opinion For Recommending Revisions To A Community Nutrition Mph Curriculum Dec 2005

Public Health Practitioner Expert Opinion For Recommending Revisions To A Community Nutrition Mph Curriculum

Florida Public Health Review

No abstract provided.


A Huntington's Christmas Story: Ten Years Of Wondering, Kenneth P. Serbin Dec 2005

A Huntington's Christmas Story: Ten Years Of Wondering, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Primary Care Nurse Attitudes, Beliefs And Confidence Levels Regarding Alcohol Abuse And Its Treatment: Impact Of Educational Intervention., Raja Sekhar Vadlamudi Dec 2005

Primary Care Nurse Attitudes, Beliefs And Confidence Levels Regarding Alcohol Abuse And Its Treatment: Impact Of Educational Intervention., Raja Sekhar Vadlamudi

Electronic Theses and Dissertations

Alcohol abuse has been a major burden on the society. In the fight against it a key issue the education of the primary care nurses has been ignored. This study evaluates the effect of education program on the attitudes, beliefs, and confidence levels of primary care nurses regarding alcohol abuse and its treatment. Data from the Project Mainstream educational intervention were used with permission from the investigators. Two hundred one students and faculty of nursing at Vanderbilt University participated in the intervention, which was designed to train primary care providers in the Brief Negotiated Intervention technique for early detection and ...


Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated With Mother-Pup Bonding During Suckling, Marcelo Febo, Michael Numan, Craig F. Ferris Dec 2005

Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated With Mother-Pup Bonding During Suckling, Marcelo Febo, Michael Numan, Craig F. Ferris

Open Access Publications by UMass Chan Authors

Oxytocin is released in the maternal brain during breastfeeding and may help strengthen the mother-infant relationship. Here, we used functional magnetic resonance imaging to determine whether oxytocin modulates brain activity in postpartum day 4-8 dams receiving suckling stimulation. During imaging sessions, dams were exposed to pup suckling before and after administration of an oxytocin receptor antagonist. Another group of dams received oxytocin alone. Changes in brain activation in response to suckling closely matched that elicited by oxytocin administration. The overlapping brain areas included the olfactory system, nucleus accumbens, insular cortex, prefrontal cortex, ventral tegmental area, cortical amygdala, and several cortical ...


Characterization Of The Interaction Between The Attachment And Fusion Glycoproteins Required For Paramyxovirus Fusion: A Dissertation, Vanessa R. Melanson Dec 2005

Characterization Of The Interaction Between The Attachment And Fusion Glycoproteins Required For Paramyxovirus Fusion: A Dissertation, Vanessa R. Melanson

Morningside Graduate School of Biomedical Sciences Dissertations and Theses

The first step of viral infection requires the binding of the viral attachment protein to cell surface receptors. Following binding, viruses penetrate the cellular membrane to deliver their genome into the host cell. For enveloped viruses, which have a lipid bilayer that surrounds their nucleocapsids, entry into the host cell requires the fusion of viral and cellular membranes. This process is mediated by viral glycoproteins located on the surface of the virus. For many enveloped viruses, such as influenza, Ebola, and human immunodeficiency virus, the fusion protein is responsible for mediating both attachment to cellular receptors and membrane fusion.

However ...


Health-Exposure Modelling And The Ecological Fallacy, Jon Wakefield, Gavin Shaddick Dec 2005

Health-Exposure Modelling And The Ecological Fallacy, Jon Wakefield, Gavin Shaddick

UW Biostatistics Working Paper Series

Recently there has been increased interest in modelling the association between aggregate disease counts and environmental exposures measured, for example via air pollution monitors, at point locations. This paper has two aims: first we develop a model for such data in order to avoid ecological bias; second we illustrate that modelling the exposure surface and estimating exposures may lead to bias in estimation of health effects. Design issues are also briefly considered, in particular the loss of information in moving from individual to ecological data, and the at-risk populations to consider in relation to the pollution monitor locations. The approach ...


Socio Economic Crisis And Mortality. Epidemiological Testimony Of The Financial Collapse Of Argentina, Enrique P. Gurfinkel, Gerardo E. Bozovich, Omar H. Dabbous, Branco Mautner, Frederick A. Anderson Jr. Dec 2005

Socio Economic Crisis And Mortality. Epidemiological Testimony Of The Financial Collapse Of Argentina, Enrique P. Gurfinkel, Gerardo E. Bozovich, Omar H. Dabbous, Branco Mautner, Frederick A. Anderson Jr.

GRACE Publications

BACKGROUND: Natural disasters, war, and terrorist attacks, have been linked to cardiac mortality. We sought to investigate whether a major financial crisis may impact on the medical management and outcomes of acute coronary syndromes.

METHODS: We analyzed the Argentine cohort of the international multicenter Global Registry of Acute Coronary Events (GRACE). The primary objective was to estimate if there was an association between the financial crisis period (April 1999 to December 2002) and in- hospital cardiovascular mortality, with the post-crisis period (January 2003 to September 2004) as the referent. Each period was defined according to the evolution of the Gross ...


Disaster And Emergency Communications Prior To Computers/Internet: A Review, John W. Farnham Dec 2005

Disaster And Emergency Communications Prior To Computers/Internet: A Review, John W. Farnham

Faculty Publications and Other Works -- Nursing

When communications are needed the most desperately and most urgently, the difficulty of effecting the desired communications increases exponentially. Recent natural disasters in different parts of the world have provided eloquent testament to this. The history of disaster or emergency communications can provide us with a foundation for understanding the problems encountered today, and can offer us insight into how we might improve the systems and processes for communications. The first applications of communication technology that allowed messages to be sent more rapidly than the fastest form of transportation were mainly military in origin. This review takes us from the ...


Dump Truck Driver Dies After Unintentional Release Of Asphalt, Kentucky Injury Prevention And Research Center Dec 2005

Dump Truck Driver Dies After Unintentional Release Of Asphalt, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On June 6, 2005 a 55-year-old male dump truck driver (Driver 1) died when he was buried waist deep in 400-degree Fahrenheit asphalt. Driver 1 stopped along the highway to help another dump truck driver (Driver 2), (both were independent truck drivers), who had experienced brake problems. As the two men were examining the pneumatic brake system at the rear of the disabled dump truck, the tailgate opened unexpectedly, spilling hot asphalt onto the decedent who was under the rear of the truck.

To prevent similar incidents, the following recommendations have been made:

Recommendation No. 1: Tailgate chains should always ...


Peripheral B Cells Latently Infected With Epstein-Barr Virus Display Molecular Hallmarks Of Classical Antigen-Selected Memory B Cells, Tatyana A. Souza, B. David Stollar, John L. Sullivan, Katherine Luzuriaga, David A. Thorley-Lawson Dec 2005

Peripheral B Cells Latently Infected With Epstein-Barr Virus Display Molecular Hallmarks Of Classical Antigen-Selected Memory B Cells, Tatyana A. Souza, B. David Stollar, John L. Sullivan, Katherine Luzuriaga, David A. Thorley-Lawson

Immunology/Infectious Disease

Epstein-Barr virus (EBV) establishes a lifelong persistent infection within peripheral blood B cells with the surface phenotype of memory cells. To date there is no proof that these cells have the genotype of true germinal-center-derived memory B cells. It is critical to understand the relative contribution of viral mimicry versus antigen signaling to the production of these cells because EBV encodes proteins that can affect the surface phenotype of infected cells and provide both T cell help and B cell receptor signals in the absence of cognate antigen. To address these questions we have developed a technique to identify single ...


Preligand Assembly Domain-Mediated Ligand-Independent Association Between Trail Receptor 4 (Tr4) And Tr2 Regulates Trail-Induced Apoptosis, Lauren Clancy, Karen Mruk, Kristina A. Archer, Melissa A. Woelfel, Juthathip Mongkolsapaya, Gavin R. Screaton, Michael J. Lenardo, Francis Ka-Ming Chan Dec 2005

Preligand Assembly Domain-Mediated Ligand-Independent Association Between Trail Receptor 4 (Tr4) And Tr2 Regulates Trail-Induced Apoptosis, Lauren Clancy, Karen Mruk, Kristina A. Archer, Melissa A. Woelfel, Juthathip Mongkolsapaya, Gavin R. Screaton, Michael J. Lenardo, Francis Ka-Ming Chan

Open Access Publications by UMass Chan Authors

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a cytokine with potential therapeutic value against cancers because of its selective cytotoxicity to many transformed, but not normal, cells. The "decoy receptors" TRAIL-R3 (TR3) and TRAIL-R4 (TR4) were believed to negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 (TR1) and TRAIL-R2 (TR2). Here, we show that inhibition of TRAIL-induced apoptosis by TR4 critically depends on its association with TR2 via the NH(2)-terminal preligand assembly domain overlapping the first partial cysteine-rich domain of both receptors. By contrast, ligand binding by TR4 is dispensable for its apoptosis ...


Obat Penggugur Kandungan Mamuju Utara 082328881996 Jual Obat Aborsi Di Mamuju Utara, Dr Fitri Dec 2005

Obat Penggugur Kandungan Mamuju Utara 082328881996 Jual Obat Aborsi Di Mamuju Utara, Dr Fitri

dr fitri

Jual Obat Penggugur Kandungan Dan Obat Aborsi Tuntas Di Kota Mamuju Utara

WA : 0823 2888 1996


Jual Obat Aborsi Di Mamuju Utara - 0823 2888 1996, Obat Aborsi Di Mamuju Utara, Obat Aborsi Mamuju Utara, Obat Telat Bulan Mamuju Utara, Obat Telat Bulan Di Mamuju Utara, Jual Obat Telat Bulan Di Mamuju Utara, Obat Penggugur Kandungan Di Mamuju Utara, Obat Pelancar Haid Di Mamuju Utara, Obat Cytotec Di Mamuju Utara, Obat Aborsi Kota Mamuju Utara, Obat Aborsi Di Wilayah Mamuju Utara, Penjual Obat Aborsi Di Mamuju Utara, Tempat Jual Obat Aborsi Di Mamuju Utara.

Cytotec Misoprostol Merupakan Obat Telat Bulan Serta ...


Analysis Of Indentation Loading Of Cortical Bone Using Acoustic Emission Techniques, Ashkan Safari, Ger Reilly, Brendan Mccormack Dec 2005

Analysis Of Indentation Loading Of Cortical Bone Using Acoustic Emission Techniques, Ashkan Safari, Ger Reilly, Brendan Mccormack

Conference Papers

In this study, we recorded the number of Acoustic emission (AE) hits and related AE energy during indentation fracture of cortical bone using a PAC PCI-2 card and pico sensor. A threshold value of 43dB was used to filter premature trigger due to background noise. Registered AE hits had more than one count (threshold crossing). Amplifier gain was set at 40dB with a (0.1-1) MHz band pass filter. 8mm cubes of cortical bones were indented in the longitudinal direction at constant crosshead speed of 1 mm min-1 using a large 2D, 50˚ wedge indenter. We hypothesised that signals occurring ...


Issn Roundtable: Faqs About The Issn, Jose Antonio, Marc Gann, Douglas Kalman, Frank Katch, Susan Kleiner, Richard Kreider, Darryn Willoughby Dec 2005

Issn Roundtable: Faqs About The Issn, Jose Antonio, Marc Gann, Douglas Kalman, Frank Katch, Susan Kleiner, Richard Kreider, Darryn Willoughby

Department of Health and Human Performance Faculty Articles

: MISSION STATEMENT OF THE ISSN : The mission of the International Society of Sports Nutrition is to be recognized as the leading professional organization in the study and application of sports nutrition. The ISSN is dedicated to promoting and supporting the study, practice, education, research and development of sports nutrition and the sports nutrition profession. All information disseminated by the ISSN is unbiased and scientifically supported.


Orally Delivered, Plant-Produced Tat Protein Primes Mice For A Challenge Dna Vaccine Expressing Tat, A V. Karasev, S Foulke, C Wellens, I Zwierzynski, R Baldwin, H Koprowski, M S. Reitz Jr Dec 2005

Orally Delivered, Plant-Produced Tat Protein Primes Mice For A Challenge Dna Vaccine Expressing Tat, A V. Karasev, S Foulke, C Wellens, I Zwierzynski, R Baldwin, H Koprowski, M S. Reitz Jr

Department of Microbiology and Immunology Faculty Papers

Oral Presentation.


Model Checking For Roc Regression Analysis, Tianxi Cai, Yingye Zheng Dec 2005

Model Checking For Roc Regression Analysis, Tianxi Cai, Yingye Zheng

Harvard University Biostatistics Working Paper Series

The Receiver Operating Characteristic (ROC) curve is a prominent tool for characterizing the accuracy of continuous diagnostic test. To account for factors that might invluence the test accuracy, various ROC regression methods have been proposed. However, as in any regression analysis, when the assumed models do not fit the data well, these methods may render invalid and misleading results. To date practical model checking techniques suitable for validating existing ROC regression models are not yet available. In this paper, we develop cumulative residual based procedures to graphically and numerically assess the goodness-of-fit for some commonly used ROC regression models, and ...


Ua12/2/1 College Heights Herald, Vol. 81, No. 23, Wku Student Affairs Dec 2005

Ua12/2/1 College Heights Herald, Vol. 81, No. 23, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. Articles in this issue:

  • Leslie, Joey. More Students Tested During AIDS Day
  • Hupman, Samantha. J-term More Popular than Anticipated
  • Fontana, Alex. Student Government Association Proposes New Bicycles for Police
  • Bosken, Nina. Students Dodge, Duck, Dive for Charity and Prizes – Special Olympics
  • Richardson, Kelly. Kentucky Community Technical College System Requests Funding – KCTCS
  • Taking the Next Step – Cultural Diversity
  • Eoff, Allison. Pass on Adderall
  • Gabler, R. XXX Ads Disappointing
  • Williams, Suzanne. A Woman’s Heart
  • Hupman, Samantha. Two Fights Reported on Hill
  • Paul, Corey. Kwanzaa to Be Celebrated Today
  • Green, Tavia ...


Evidence-Based Practice For Public Health Project: Final Report, E. Hatheway Simpson, Elaine R. Martin Dec 2005

Evidence-Based Practice For Public Health Project: Final Report, E. Hatheway Simpson, Elaine R. Martin

Library Publications

There are numerous clinically based models for finding the “best evidence” for the diagnosis and treatment of disease. This process is called evidence-based medicine or EBM, which has been defined as "the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients. The practice of evidence-based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research”.1 The need for improved access to high quality public health information has been echoed in various forums involving public health professionals, librarians, and information specialists since the mid 1990s ...


Redesigning Practice To Improve Care Delivery (Boston), Laura A. Dummit, Lisa Sprague Dec 2005

Redesigning Practice To Improve Care Delivery (Boston), Laura A. Dummit, Lisa Sprague

National Health Policy Forum

This site visit focused on how the practice of medicine is changing or can be changed to improve care delivery across the spectrum of patient populations. Regarded as a “medical Mecca,” Boston is home to the academic health centers and teaching hospitals where many of the nation’s physicians are trained. As a center of innovation, Boston prides itself on its high bar with respect to standards of care. Panels addressed the used of clinical information technology (IT) in the physician’s office, in the hospital, and community-wide. Participants observed how IT is being used to further the mission of ...


Overcoming Fas-Mediated Apoptosis Accelerates Helicobacter-Induced Gastric Cancer In Mice, Xun Cai, Calin Stoicov, Hanchen Li, Jane E. Carlson, Mark T. Whary, James G. Fox, Jeanmarie Houghton Dec 2005

Overcoming Fas-Mediated Apoptosis Accelerates Helicobacter-Induced Gastric Cancer In Mice, Xun Cai, Calin Stoicov, Hanchen Li, Jane E. Carlson, Mark T. Whary, James G. Fox, Jeanmarie Houghton

Open Access Publications by UMass Chan Authors

The initiating molecular events in Helicobacter-induced gastric carcinogenesis are not known. Early in infection, Fas antigen-mediated apoptosis depletes parietal and chief cell populations, leading to architectural distortion. As infection progresses, metaplastic and dysplastic glands appear, which are resistant to Fas-mediated apoptosis. These abnormal lineages precede, and are thought to be the precursor lesions of, gastric cancer. Acquisition of an antiapoptotic phenotype before transformation of cells suggests that loss of Fas sensitivity may be an early required trait for gastric cancer. We reasoned that forced Fas-apoptosis resistance would result in earlier and more aggressive gastric cancer in our mouse model. Fas ...


History-Adjusted Marginal Structural Models To Estimate Time-Varying Effect Modification , Maya L. Petersen, Steven G. Deeks, Jeffrey N. Martin, Mark J. Van Der Laan Dec 2005

History-Adjusted Marginal Structural Models To Estimate Time-Varying Effect Modification , Maya L. Petersen, Steven G. Deeks, Jeffrey N. Martin, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Much of epidemiology and clinical medicine is focused on the estimation of treatments or interventions administered over time. In such settings of longitudinal treatment, time-dependent confounding is often an important source of bias. Marginal structural models are a powerful tool for estimating the causal effect of a treatment using observational data, particularly when time-dependent confounding is present. Recent statistical work presented a generalization of marginal structural models, called history-adjusted marginal structural models. Unlike standard marginal structural models, history-adjusted marginal structural models can be used to estimate modification of treatment effects by time-varying covariates. Estimation of time-dependent causal effect modification is ...


A Thanksgiving Visit: A Time To Reflect On Hd, Kenneth P. Serbin Dec 2005

A Thanksgiving Visit: A Time To Reflect On Hd, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Improved Peak Detection And Quantification Of Mass Spectrometry Data Acquired From Surface-Enhanced Laser Desorption And Ionization By Denoising Spectra With The Undecimated Discrete Wavelet Transform, Kevin R. Coombes, Spiros Tsavachidis, Jeffrey S. Morris, Keith A. Baggerly, Henry M. Kuerer Dec 2005

Improved Peak Detection And Quantification Of Mass Spectrometry Data Acquired From Surface-Enhanced Laser Desorption And Ionization By Denoising Spectra With The Undecimated Discrete Wavelet Transform, Kevin R. Coombes, Spiros Tsavachidis, Jeffrey S. Morris, Keith A. Baggerly, Henry M. Kuerer

Jeffrey S. Morris

Background: Mass spectrometry, especially surface enhanced laser desorption and ionization (SELDI) is increasingly being used to find disease-related proteomic patterns in complex mixtures of proteins derived from tissue samples or from easily obtained biological fluids such as serum, urine, or nipple aspirate fluid. Questions have been raised about the reproducibility and reliability of peak quantifications using this technology. For example, Yasui and colleagues opted to replace continuous measures of the size of a peak by a simple binary indicator of its presence or absence in their analysis of a set of spectra from prostate cancer patients.

Methods: We collected nipple ...