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2005

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Articles 1 - 30 of 2703

Full-Text Articles in Medicine and Health Sciences

Physiologic Assessment Of Blood Glucose Homeostasis Via Combined Intravenous Glucose And Insulin Testing In Horses, Hugo Eiler, Nicholas Frank, Frank Andrews, Jack Oliver, Kellie Fecteau Jun 2014

Physiologic Assessment Of Blood Glucose Homeostasis Via Combined Intravenous Glucose And Insulin Testing In Horses, Hugo Eiler, Nicholas Frank, Frank Andrews, Jack Oliver, Kellie Fecteau

Kellie Fecteau

Objective - To characterize the physiologic response to IV bolus injection of glucose and insulin for development of a combined glucose-insulin test (CGIT) in horses. Animals - 6 healthy mares and 1 mare each with pituitary adenoma and urolithiasis. Procedure - Horses were given a CGIT (glucose, 150 mg/kg; insulin, 0.1 U/kg); results were compared with a singular IV glucose tolerance test (GTT; 150 mg/kg) and a singular IV insulin sensitivity test (IST; 0.1 U/kg). Healthy horses were also given a CGIT after receiving xylazine and undergoing stress. Results - Physiologically, the CGIT resulted in a 2-phase curve ...


Gamma-Cleavage Is Dependent On Zeta-Cleavage During The Proteolytic Processing Of Amyloid Precursor Protein Within Its Transmembrane Domain., Guojun Zhao, Mei-Zhen Cui, Guozhang Mao, Jianxin Tan, Yunzhou Dong, Longsheng Sun, Xuemin Xu Jun 2013

Gamma-Cleavage Is Dependent On Zeta-Cleavage During The Proteolytic Processing Of Amyloid Precursor Protein Within Its Transmembrane Domain., Guojun Zhao, Mei-Zhen Cui, Guozhang Mao, Jianxin Tan, Yunzhou Dong, Longsheng Sun, Xuemin Xu

Mei-Zhen Cui

beta-Amyloid precursor protein apparently undergoes at least three major cleavages, gamma-, epsilon-, and the newly identified zeta-cleavage, within its transmembrane domain to produce secreted beta-amyloid protein (Abeta). However, the roles of epsilon- and zeta-cleavages in the formation of secreted Abeta and the relationship among these three cleavages, namely epsilon-, zeta-, and gamma-cleavages, remain elusive. We investigated these issues by attempting to determine the formation and turnover of the intermediate products generated by these cleavages, in the presence or absence of known gamma-secretase inhibitors. By using a differential inhibition strategy, our data demonstrate that Abeta(46) is an intermediate precursor of ...


Effects Of Administration Of Ergotamine Tartrate On Fertility Of Yearling Beef Bulls, Gm Schuenemann, Jl Edwards, Md Davis, He Blackmon, Fn Scenna, Barton Rohrbach, Am Saxton, Henry Adair, Iii, Fm Hopkins, Jc Waller, Fn Schrick Aug 2012

Effects Of Administration Of Ergotamine Tartrate On Fertility Of Yearling Beef Bulls, Gm Schuenemann, Jl Edwards, Md Davis, He Blackmon, Fn Scenna, Barton Rohrbach, Am Saxton, Henry Adair, Iii, Fm Hopkins, Jc Waller, Fn Schrick

Barton W Rohrbach Dr.

Sixteen yearling bulls were utilized to investigate administration of ergotamine tartrate on semen parameters, fertilization, and endocrinology. Bulls were allotted to a control diet of cracked corn, corn silage, and soybean meal (CON, n = 8) or a diet supplemented daily with 40 microg/kg body weight of ergotamine tartrate (ET, n = 8). Blood samples, average daily gain, scrotal circumference and rectal temperatures were collected every 14 day. Semen samples were obtained every 60 day and evaluated for motility and morphology. Scrotal temperatures were obtained by thermography immediately before electroejaculation. Semen from a subset of bulls from each treatment was also ...


Pilot Study Of Echocardiographic Studies Using Color- And Pulsed-Wave Spectral Doppler Methods In Blue-Crowned Amazons (Amazona Ventralis) And Blue-Fronted Amazons (Amazona A. Aestiva), M Pees, J Straub, Juergen Schumacher, Rebecca Gompf, M Krautwalkd-Jung-Hanns Jul 2012

Pilot Study Of Echocardiographic Studies Using Color- And Pulsed-Wave Spectral Doppler Methods In Blue-Crowned Amazons (Amazona Ventralis) And Blue-Fronted Amazons (Amazona A. Aestiva), M Pees, J Straub, Juergen Schumacher, Rebecca Gompf, M Krautwalkd-Jung-Hanns

Juergen P. Schumacher

Colour-flow and pulsed-wave spectral Doppler echocardiography was performed on 6 healthy, adult Hispaniolan amazon parrots (Amazona ventralis) and 6 blue-fronted amazon parrots (Amazona a. aestiva) to establish normal reference values. Birds were anesthetized with isoflurane in oxygen and placed in dorsal recumbency. An electrocardiogram was recorded continuously and birds were imaged with a micro-phased-array scanner with a frequency of 7.0 MHz. After assessment of cardiac function in 2-D-echocardiography, blood flow across the left and the right atrioventricular valve and across the aortic valve was determined using color-flow and pulsed-wave spectral Doppler echocardiography. Diastolic inflow (mean value +/- standard deviation) into ...


Quality Of Life And Stress Factors For Veterinary Medical Students, Elizabeth Strand, T.L. Zaparanick, James Brace Jul 2012

Quality Of Life And Stress Factors For Veterinary Medical Students, Elizabeth Strand, T.L. Zaparanick, James Brace

James J Brace

Psychological distress has been shown to affect the academic success, health, emotional well-being, and dropout rates of medical students. Although it can be assumed that stress has similar effects on veterinary students, there is a paucity of research pertaining to the psychological stressors and coping strategies of this group. This article focuses on selected non-academic areas (as identified through a survey of currently enrolled students) that can create significant stressors for veterinary students. Also assessed and discussed here are poor coping strategies (e.g., substance abuse) and gender differences in perceived stressors and coping strategies that emerged from the survey ...


Improved Method For Dried Anatomical Specimen Preparation, I Arnautovic, Robert Henry, H Pobric, R Avdic, V Cutahija, M Tabakovic, Robert Reed Jul 2012

Improved Method For Dried Anatomical Specimen Preparation, I Arnautovic, Robert Henry, H Pobric, R Avdic, V Cutahija, M Tabakovic, Robert Reed

Robert B. Reed, Jr., DVM, Ph.D.

Dessicated organs used for teaching purposes are susceptible to insect damage as well as damage due to improper handling. Injection of expanding foam products into the lumen of dessicated organs followed by varnishing produces anatomical specimens resistant to insect damage and more resilient to the strains of handling. This study will describe the production of such specimens.


Dysphagia As The Primary Clinical Abnormality In Two Dogs With Inflammatory Myopathy, R Ryckman, D Krahwinkel, Michael Sims, Robert Donnell, E Engvall, D Shelton Mar 2012

Dysphagia As The Primary Clinical Abnormality In Two Dogs With Inflammatory Myopathy, R Ryckman, D Krahwinkel, Michael Sims, Robert Donnell, E Engvall, D Shelton

Michael H. Sims

Two adult Boxers were evaluated because of chronic dysphagia of several years' duration. Serum creatine kinase activity was high in both dogs, but other hematologic or serum biochemical abnormalities were not detected. Esophagraphy revealed abnormalities of the cricopharyngeal phase of swallowing in both dogs, and electromyography of the pharyngeal and laryngeal muscles revealed complex repetitive discharges, positive sharp waves, and fibrillation potentials characteristic of primary myopathy or neuropathy. Because of the severity of their condition, both dogs were euthanatized. Histologically, mixed-cell infiltrates were seen in sections of the masseter and thyropharyngeal muscles. Results of indirect immunofluorescence staining for proteins associated ...


Renal Adenocarcinoma, Hepatocellular Carcinoma, And Pancreatic Islet Cell Carcinoma In A Binturong ( Arctictis Binturong), Eric Klaphake, A Shoeib, Edward Ramsay, Juergen Schumacher, Linden Craig Feb 2012

Renal Adenocarcinoma, Hepatocellular Carcinoma, And Pancreatic Islet Cell Carcinoma In A Binturong ( Arctictis Binturong), Eric Klaphake, A Shoeib, Edward Ramsay, Juergen Schumacher, Linden Craig

Linden E. Craig DVM, Ph.D., DACVP, College of Veterinary Medicine

No abstract provided.


Tobacco Control: Are We Appropriately Training Future Health Professionals, Francisco Soto Mas, Chiehwen Hsu Jan 2012

Tobacco Control: Are We Appropriately Training Future Health Professionals, Francisco Soto Mas, Chiehwen Hsu

Francisco Soto Mas

Information on how health professionals perceive tobacco use as well as their attitudes toward tobacco control is scarce. This study assessed the attitudes and perceptions of public health students toward tobacco use and tobacco control, which constitutes a necessary first step in designing effective training strategies. Although the majority of respondents agreed that tobacco use constitutes a relevant public health problem, they did not perceive tobacco control to be a public health priority. Academic institutions may not be properly training public health students, and may therefore be missing the opportunity to advance tobacco control at the national and global levels.


Serologic Survey Of Felids In The Peten Region Of Guatemala, Adrienne Lickey, Melissa Kennedy, Sharon Patton, Edward Ramsay Jan 2012

Serologic Survey Of Felids In The Peten Region Of Guatemala, Adrienne Lickey, Melissa Kennedy, Sharon Patton, Edward Ramsay

Melissa A. Kennedy

Blood samples were analyzed from 30 domestic cats (Felis domesticus) from the Petén region of Guatemala to determine the seroprevalence of common pathogens that may pose a potential risk to native wild felids. Eight of the cats had been vaccinated previously; however, owners were unable to fully describe the type of vaccine and date of administration. In addition, blood samples were obtained from two captive margays (Leopardus wiedii). Samples were tested for antibodies to feline immunodeficiency virus, Dirofilaria immitis, feline panleukopenia virus, feline herpesvirus, feline coronavirus, canine distemper virus, and Toxoplasma gondii and for feline leukemia virus (FeLV) antigen. Fifty ...


Veterinary Nutrition Today: A U.S. Perspective, Claudia Kirk, Joe Bartges Dec 2011

Veterinary Nutrition Today: A U.S. Perspective, Claudia Kirk, Joe Bartges

Claudia A Kirk

No abstract provided.


Biomechanics Of Rehabilitation, Joseph Weigel, Greg Arnold, David Hicks, Darryl Millis Nov 2011

Biomechanics Of Rehabilitation, Joseph Weigel, Greg Arnold, David Hicks, Darryl Millis

Darryl L. Millis

Biomechanics may be defined as the application of the discipline of mechanics to biologic systems. Rehabilitation is a practice dedicated to the restoration of function to a body impaired by injury or disease. Because rehabilitation is focused on the form and motion of a system of interrelated parts, an appreciation for biomechanical theory and application is appropriate. This application provides a basis for understanding diagnostic and evaluation methods, treatment modalities, and pathologic effects of the affected musculoskeletal system. This article presents applicable mechanical theory, including the concepts of moment and lever systems; linear kinetics of ground reaction forces (GRFs), linear ...


Online Academic Libraries And Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson Oct 2011

Online Academic Libraries And Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson

Bruce Lubostsky Levin, DrPH, MPH

Although educational institutions create courses and programs for distance learners, they often omit the support component that librarians and accrediting organizations consider critical.


Determination And Evaluation Of An Optimal Dosage Of Carfentanil And Xylazine For The Immobilization Of White-Tailed Deer (Odocoileus Virginianus), Timothy Storms, Juergen Schumacher, Nancy Zagaya, David Osborn, Karl Miller, Edward Ramsay Aug 2011

Determination And Evaluation Of An Optimal Dosage Of Carfentanil And Xylazine For The Immobilization Of White-Tailed Deer (Odocoileus Virginianus), Timothy Storms, Juergen Schumacher, Nancy Zagaya, David Osborn, Karl Miller, Edward Ramsay

Juergen P. Schumacher

Using an iteration method, optimal hand-injected immobilization dosages of carfentanil/xylazine (CAR/XYL) were determined for 13 adult white-tailed deer (Odocoileus virginianus). Deer were temporarily restrained in a squeeze chute and were repeatedly immobilized one to four times at 2–5-wk intervals from December 2002 to March 2003. A fixed ratio of 1 mg CAR:10 mg XYL intramuscularly was used, increasing or decreasing the dosage until the optimal dosage (defined by an induction time<3 min and PaCO2< 60 mmHg) was reached for each animal. Inductions were videorecorded and reviewed by observers blinded to drugs and dosages, who rated qualitative aspects of each induction. There were significant (P<0.05) dosage-dependent decreases in induction time, time to first effect, PaO2, SaO2, and arterial pH, and significant dosage-dependent increases in PaCO2 and quality ratings. The median optimal dosage (mOD) was 0.03 ...


Effect Of A 24-Hour Infusion Of An Isotonic Electrolyte Replacement Fluid On The Renal Clearance Of Electrolytes In Healthy Neonatal Foals, B Buchanan, Carla Sommardahl, Barton Rohrbach, Frank Andrews Aug 2011

Effect Of A 24-Hour Infusion Of An Isotonic Electrolyte Replacement Fluid On The Renal Clearance Of Electrolytes In Healthy Neonatal Foals, B Buchanan, Carla Sommardahl, Barton Rohrbach, Frank Andrews

Carla S. Sommardahl

Objective - To determine the effects of a 24-hour infusion of an isotonic electrolyte replacement fluid (IERF) on weight, serum and urine electrolyte concentrations, and other clinicopathologic variables in healthy neonatal foals. Animals - 4 healthy 4-day-old foals. Design - Prospective study. Procedure - An IERF was administered to each foal at an estimated rate of 80 mL/kg/d (36.4 mL/lb/d) for 24 hours. Body weight was measured before and after the infusion period. Urine was collected via catheter during 4-hour periods; blood samples were collected at 4-hour intervals. Variables including urine production; urine and serum osmolalities; sodium, potassium, and ...


Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer, Madhu Dhar, Maria Cekanova, Hildegard Schuller Aug 2011

Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer, Madhu Dhar, Maria Cekanova, Hildegard Schuller

Howard K. Plummer III

BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six ...


Expression Of The Α7 Nicotinic Acetylcholine Receptor In Human Lung Cells, Howard Plummer, Madhu Dhar, Hildegard Schuller Aug 2011

Expression Of The Α7 Nicotinic Acetylcholine Receptor In Human Lung Cells, Howard Plummer, Madhu Dhar, Hildegard Schuller

Howard K. Plummer III

Background We and others have shown that one of the mechanisms of growth regulation of small cell lung cancer cell lines and cultured pulmonary neuroendocrine cells is by the binding of agonists to the α7 neuronal nicotinic acetylcholine receptor. In addition, we have shown that the nicotine-derived carcinogenic nitrosamine, 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a high affinity agonist for the α7 nicotinic acetylcholine receptor. In the present study, our goal was to determine the extent of α7 mRNA and protein expression in the human lung. Methods Experiments were done using reverse transcription polymerase chain reaction (RT-PCR), a nuclease ...


Comparison Of Oral And Subcutaneous Administration Of Buprenorphine And Meloxicam For Preemptive Analgesia In Cats Undergoing Ovariohysterectomy, A Gassel, Karen Tobias, Christine Egger, Barton Rohrbach Jun 2011

Comparison Of Oral And Subcutaneous Administration Of Buprenorphine And Meloxicam For Preemptive Analgesia In Cats Undergoing Ovariohysterectomy, A Gassel, Karen Tobias, Christine Egger, Barton Rohrbach

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Objective - To compare the effectiveness of preoperative PO and SC administration of buprenorphine and meloxicam for prevention of postoperative pain-associated behaviors in cats undergoing ovariohysterectomy. Design - Randomized controlled study. Animals - 51 female cats (4 to 60 months old; weight range, 1.41 to 4.73 kg [3.1 to 10.4 lb]). Procedure - Cats received 1 of 5 treatments at the time of anesthetic induction: buprenorphine PO (0.01 mg/kg [0.0045 mg/lb]; n=10), buprenorphine SC (0.01 mg/kg; 10), meloxicam SC (0.3 mg/kg [0.14 mg/lb]; 10), meloxicam PO (0.3 mg ...


Monoethylglycinexylidide And Lidocaine Determination In Porcine Microsomal Preparations, Sherry Cox, T Hamner, Joe Bartges Jun 2011

Monoethylglycinexylidide And Lidocaine Determination In Porcine Microsomal Preparations, Sherry Cox, T Hamner, Joe Bartges

Sherry Cox

A simple, accurate, and sensitive HPLC analysis of monoethylglycinexylidide (MEGX) and lidocaine in porcine microsome samples is described. Lidocaine and MEGX were measured by direct injection after the addition of the internal standard. Chromatography was performed on a muBondapak C(18) column using an isocratic mobile phase of 0.03 M potassium dihydrogen phosphate:acetonitrile (87:13), pH 5.9. UV absorbance was measured at 205 nm. The procedure produced linear curves for the concentration range 50-1000 ng/mL with a limit of detection of 10 ng/mL. Recoveries for both compounds were greater than 90%. This assay produced accurate ...


Online Academic Libraries And Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson May 2011

Online Academic Libraries And Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson

Merilyn S Burke

Although educational institutions create courses and programs for distance learners, they often omit the support component that librarians and accrediting organizations consider critical.


Effect Of Vaccination Against Leptospirosis On The Frequency, Days To Recurrence And Progression Of Disease In Horses With Equine Recurrent Uveitis, Barton Rohrbach, D Ward, Diane Hendrix, M Cawrse-Foss, T Moyers Sep 2010

Effect Of Vaccination Against Leptospirosis On The Frequency, Days To Recurrence And Progression Of Disease In Horses With Equine Recurrent Uveitis, Barton Rohrbach, D Ward, Diane Hendrix, M Cawrse-Foss, T Moyers

Diane Hendrix

Objective: To evaluate the effect of vaccination against leptospirosis on frequency and days to recurrence of uveitis and progression of disease in horses with equine recurrent uveitis (ERU). Animals: Forty-one horses with ERU. Procedure: Horses were randomly assigned to experimental (vaccinated) or control groups. Vaccine containing six serovars of Leptospira or placebo was administered, an ophthalmic examination performed and blood samples drawn on days 0, 28, 180 and 365. Antibody titers were measured against each serovar. Recurrence of uveitis was verified by ophthalmic examination. Results of the initial and final ophthalmic examinations were compared and progression of disease defined as ...


Do Industrial Back Support Belts Reduce Stress In Asymmetric Lifting?, Ryan Jamor Brown Dec 2005

Do Industrial Back Support Belts Reduce Stress In Asymmetric Lifting?, Ryan Jamor Brown

Theses

The objective of this research is to determine the effects of wearing a back support belt during repetitive asymmetric lifting in terms of heart rate, blood pressure, static lift capacity, body discomfort rating and subjective rating concerning the effectiveness of a back support belt. The type of belt used in this study was of knit nylon and elastic construction designed for industrial use.

Eight female participants lifted a crate from the table to knuckle height at a rate of three lifts per minute for a period of 20 minutes; one set with wearing back support belt and one without back ...


Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, George Q. Daley Dec 2005

Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, George Q. Daley

Open Dartmouth: Faculty Open Access Articles

Despite two decades of studies documenting the in vitro blood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exploited the Cdx-Hox pathway, a genetic program important for blood development, to enhance the differentiation of ESCs along the hematopoietic lineage. Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4 , we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice. Clonal analysis of retroviral integration sites confirms ...


Rapid, Diffusional Shuttling Of Poly(A) Rna Between Nuclear Speckles And The Nucleoplasm, Joan C. Ritland Politz, Richard A. Tuft, Kannanganattu V. Prasanth, Nina Baudendistel, Kevin E. Fogarty, Lawrence M. Lifshitz, Jorg Langowski, David L. Spector, Thoru Pederson Dec 2005

Rapid, Diffusional Shuttling Of Poly(A) Rna Between Nuclear Speckles And The Nucleoplasm, Joan C. Ritland Politz, Richard A. Tuft, Kannanganattu V. Prasanth, Nina Baudendistel, Kevin E. Fogarty, Lawrence M. Lifshitz, Jorg Langowski, David L. Spector, Thoru Pederson

Open Access Articles

Speckles are nuclear bodies that contain pre-mRNA splicing factors and polyadenylated RNA. Because nuclear poly(A) RNA consists of both mRNA transcripts and nucleus-restricted RNAs, we tested whether poly(A) RNA in speckles is dynamic or rather an immobile, perhaps structural, component. Fluorescein-labeled oligo(dT) was introduced into HeLa cells stably expressing a red fluorescent protein chimera of the splicing factor SC35 and allowed to hybridize. Fluorescence correlation spectroscopy (FCS) showed that the mobility of the tagged poly(A) RNA was virtually identical in both speckles and at random nucleoplasmic sites. This same result was observed in photoactivation-tracking studies in ...


Prevalence Of Overweight In Children And Adolescents With Attention Deficit Hyperactivity Disorder And Autism Spectrum Disorders: A Chart Review, Carol Curtin, Linda G. Bandini, Ellen C. Perrin, David J. Tybor, Aviva Must Dec 2005

Prevalence Of Overweight In Children And Adolescents With Attention Deficit Hyperactivity Disorder And Autism Spectrum Disorders: A Chart Review, Carol Curtin, Linda G. Bandini, Ellen C. Perrin, David J. Tybor, Aviva Must

Open Access Articles

BACKGROUND: The condition of obesity has become a significant public health problem in the United States. In children and adolescents, the prevalence of overweight has tripled in the last 20 years, with approximately 16.0% of children ages 6-19, and 10.3% of 2-5 year olds being considered overweight. Considerable research is underway to understand obesity in the general pediatric population, however little research is available on the prevalence of obesity in children with developmental disorders. The purpose of our study was to determine the prevalence of overweight among a clinical population of children diagnosed with attention deficit hyperactivity disorder ...


Health Information Access Dec 2005

Health Information Access

The Southeastern Librarian

The National Network of Libraries of Medicine, Southeastern Atlantic Region, wishes to remind libraries in the region that they provide training and assistance with health information access to the public.


A Hybrid Model For Reducing Ecological Bias, Ruth Salway, Jon Wakefield Dec 2005

A Hybrid Model For Reducing Ecological Bias, Ruth Salway, Jon Wakefield

UW Biostatistics Working Paper Series

A major drawback of epidemiological ecological studies, in which the association between area-level summaries of risk and exposure are used to make inference about individual risk, is the difficulty in characterising within-area variability in exposure and confounder variables. To avoid ecological bias, samples of individual exposure/confounder data within each area are required. Unfortunately these may be difficult or expensive to obtain, particularly if large samples are required. In this paper we propose a new approach suitable for use with small samples. We combine a Bayesian non-parametric Dirichlet process prior with an estimating functions approach, and show that this model ...


Secretory Leucoprotease Inhibitor Binds To Nf-Kappab Binding Sites In Monocytes And Inhibits P65 Binding., Clifford C. Taggart, Sally-Ann Cryan, Sinead Weldon, Aileen Gibbons, Catherine M. Greene, Emer Kelly, Teck Boon Low, Shane J. O'Neill, Noel G. Mcelvaney Dec 2005

Secretory Leucoprotease Inhibitor Binds To Nf-Kappab Binding Sites In Monocytes And Inhibits P65 Binding., Clifford C. Taggart, Sally-Ann Cryan, Sinead Weldon, Aileen Gibbons, Catherine M. Greene, Emer Kelly, Teck Boon Low, Shane J. O'Neill, Noel G. Mcelvaney

Medicine Articles

Secretory leucoprotease inhibitor (SLPI) is a nonglycosylated protein produced by epithelial cells. In addition to its antiprotease activity, SLPI has been shown to exhibit antiinflammatory properties, including down-regulation of tumor necrosis factor alpha expression by lipopolysaccharide (LPS) in macrophages and inhibition of nuclear factor (NF)-kappaB activation in a rat model of acute lung injury. We have previously shown that SLPI can inhibit LPS-induced NF-kappaB activation in monocytic cells by inhibiting degradation of IkappaBalpha without affecting the LPS-induced phosphorylation and ubiquitination of IkappaBalpha. Here, we present evidence to show that upon incubation with peripheral blood monocytes (PBMs) and the U937 ...


Primary Care Nurse Attitudes, Beliefs And Confidence Levels Regarding Alcohol Abuse And Its Treatment: Impact Of Educational Intervention., Raja Sekhar Vadlamudi Dec 2005

Primary Care Nurse Attitudes, Beliefs And Confidence Levels Regarding Alcohol Abuse And Its Treatment: Impact Of Educational Intervention., Raja Sekhar Vadlamudi

Electronic Theses and Dissertations

Alcohol abuse has been a major burden on the society. In the fight against it a key issue the education of the primary care nurses has been ignored. This study evaluates the effect of education program on the attitudes, beliefs, and confidence levels of primary care nurses regarding alcohol abuse and its treatment. Data from the Project Mainstream educational intervention were used with permission from the investigators. Two hundred one students and faculty of nursing at Vanderbilt University participated in the intervention, which was designed to train primary care providers in the Brief Negotiated Intervention technique for early detection and ...


Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated With Mother-Pup Bonding During Suckling, Marcelo Febo, Michael Numan, Craig F. Ferris Dec 2005

Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated With Mother-Pup Bonding During Suckling, Marcelo Febo, Michael Numan, Craig F. Ferris

Open Access Articles

Oxytocin is released in the maternal brain during breastfeeding and may help strengthen the mother-infant relationship. Here, we used functional magnetic resonance imaging to determine whether oxytocin modulates brain activity in postpartum day 4-8 dams receiving suckling stimulation. During imaging sessions, dams were exposed to pup suckling before and after administration of an oxytocin receptor antagonist. Another group of dams received oxytocin alone. Changes in brain activation in response to suckling closely matched that elicited by oxytocin administration. The overlapping brain areas included the olfactory system, nucleus accumbens, insular cortex, prefrontal cortex, ventral tegmental area, cortical amygdala, and several cortical ...