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Full-Text Articles in Medicine and Health Sciences

Mechanical Properties Of Canine Patella-Ligament-Tibia Segment., Jeffery Biskup, Andy Freeman, W Camisa, J Innes, Michael Conzemius Jan 2104

Mechanical Properties Of Canine Patella-Ligament-Tibia Segment., Jeffery Biskup, Andy Freeman, W Camisa, J Innes, Michael Conzemius

Jeffery Biskup, DVM, DACVS

OBJECTIVE: To test the ex vivo mechanical properties of canine patella-ligament-tibia (PLT) segment and establish the relationship between donor size and PLT dimensions to the mechanical properties of PLT grafts.STUDY DESIGN: Ex vivo mechanical testing study. SAMPLE POPULATION: Canine PLT segments (n = 21 dogs; 42 PLT). METHODS:Morphometric measurements of PLT segments were taken from computed tomography (CT) images and compared with results obtained using calipers. PLT were tested to failure at a rate of 100% length/s. Mechanical properties and failure mode were recorded. RESULTS: PLT width and thickness (P < .001 for both) measured by calipers were significantly lower than those taken from CT images. Thirty-five (83%) specimens failed by avulsion fracture from the patella, 1 failed mid-ligament, and 6 failed by tibial fracture. Dog weight and PLT length had the strongest Pearson's r value when correlated with load at failure (r = 0.73, 0.81, respectively). CONCLUSION:Dog weight and PLT length were the best predictors of load at failure. PLT failure load of dogs weighing >25 kg were similar to those reported for ...


Preparing For A National Weightlifting Championships: A Case Series, S. Kyle Travis, Satoshi Mizuguchi, Michael H. Stone, William A. Sands, Caleb D. Bazyler Feb 2019

Preparing For A National Weightlifting Championships: A Case Series, S. Kyle Travis, Satoshi Mizuguchi, Michael H. Stone, William A. Sands, Caleb D. Bazyler

Caleb D. Bazyler

INTRODUCTION: Monitoring an athlete’s psychological, physiological, and performance level is important when preparing for a major competition. No study to date has tracked a high-level weightlifter peaking for a major competition all the way up to the day of competition. Assessing performance at a competition is vital to ascertain if the athlete has reached a peaked and if peak performance will actually be expressed during the competition. PURPOSE: Therefore, the purpose of this study was to determine when peak jumping performance was achieved and whether psychological or physiological variables explained any jump performance changes in a high-level female weightlifter ...


Trends In Patient Selection And Postoperative Outcomes After Pancreatoduodenectomy. A 10-Year Retrospective Acs Nsqip Database Analysis, Jan Grendar, Zelika Jutric, Shu-Ching Chang, L Wang, E Tang, P Newell, C Hammill Jun 2018

Trends In Patient Selection And Postoperative Outcomes After Pancreatoduodenectomy. A 10-Year Retrospective Acs Nsqip Database Analysis, Jan Grendar, Zelika Jutric, Shu-Ching Chang, L Wang, E Tang, P Newell, C Hammill

Shu-Ching Chang, PhD, MS

Objective: We aimed to assess trends in patient selection and outcomes to evaluate safety in current practice of pancreatoduodenectomy. Methods: NSQIP database from 2005 to 2014 was used to identify patients undergoing a pancreatoduodenectomy. Preoperative optimization measure was created using lack of >10% weight loss, albumin>3 and bilirubin<2. Annual trends in patient characteristics and outcomes were described in univariate and logistic or linear regression analyses for binary and continuous variables, respectively. Results: 23,295 pancreatoduodenectomies were identified. There was no significant trend of age (overall median 65 years, trend p=0.31), severity of systemic disease increased (ASA≥3 in 73% overall, trend OR=1.07, p<0.001), but so did the rate of preoperative optimization (52% overall, trend OR=1.03, p<0.001). Malignant indication percentage was increasing (75% overall, trend OR=1.04, p<0.001) as was rate of associated vascular resection (8% overall, trend OR=1.09, p<0.001), but not multivisceral resections (4% overall, trend p=0.10). The adjusted odds of minor and major complications increased over time (overall 31.2% and 27.7%, trend OR=1.32 and 1.11 respectively, p<0.001 for both). In contrast, unadjusted and adjusted length of stay was shortening (median 9 days, decrease by 1.60% and 1.44% respectively, p<0.001 for both) and mortality continued to decrease (2.5% overall, trend OR=0.95, p=0.002). Conclusion: There has been increasing severity of systemic disease as well as more advanced primary disease in patients undergoing pancreatoduodenectomy. Despite increasing complication rates, preoperative optimization and management of complications were likely improved, as suggested by shortening length of stay and decreasing mortality.


Occupational Therapy’S Emerging Role With Transitioning Adolescents In Foster Care, A. Paul-Ward, Carol A. Lambdin-Pattavina May 2018

Occupational Therapy’S Emerging Role With Transitioning Adolescents In Foster Care, A. Paul-Ward, Carol A. Lambdin-Pattavina

Carol Lambdin-Pattavina

The American Occupational Therapy Association’s Centennial Vision advocates for an emphasis on intervention and prevention services for children, young people, the aging, and those with severe and persistent mental illness. This article discusses mental health issues among adolescents in foster care, a population that would greatly benefit from occupational therapy services emphasizing skill development in the areas of independent living, vocation, and health. Additionally, current intervention modalities used by other disciplines with adolescents in foster care are explored. Finally, a pilot study demonstrating the opportunities for occupational therapists to influence the long-term outcomes of adolescents in foster care is ...


Bone Conduction Transmission And Head‐Shadow Effects For Unilateral Hearing Losses Fit With Transcranial Cic Hearing Aids, Marc A. Fagelson, Colleen Noe, Jennifer Blevins, Owen Murnane Apr 2018

Bone Conduction Transmission And Head‐Shadow Effects For Unilateral Hearing Losses Fit With Transcranial Cic Hearing Aids, Marc A. Fagelson, Colleen Noe, Jennifer Blevins, Owen Murnane

Owen D. Murnane

Bone conduction transmission and head‐shadow effects were determined with transcranial completely‐in‐the‐canal (TCCIC) CROS hearing aids. Five subjects with documented profound unilateral hearing loss and experience with traditional CROS/BICROS fittings (TCROS) were tested with a CIC hearing aid placed in their poorer ear. Peak SPL was measured at the tympanic membrane and ranged from 105–115 dB SPL at 2000 Hz. Pure‐tone crossover thresholds and functional gain tested at frequencies from 250–8000 Hz varied considerably more than the SPL measures. The pure‐tone results indicated that sensitivity in the better ear was moderately associated ...


Gap Discrimination And Speech Perception In Noise, Marc A. Fagelson Apr 2018

Gap Discrimination And Speech Perception In Noise, Marc A. Fagelson

Marc A. Fagelson

The relation between discrimination of silent gaps and speech‐in‐noise perception was measured in 20 normal‐hearing listeners using speech‐shaped noise as both the gap markers and the noise source for speech testing. In the gap discrimination experiment, subjects compared silent gaps marked by 60 dB SPL 250‐ms noise bursts to standards of either 5, 10, 20, 50, 100, or 200 ms. The gap results were most similar to those reported by Abel [S. M. Abel, J. Acoust. Soc. Am. 52, 519–524 (1972)] as ΔT/T decreased non‐monotonically with increased gap length. In a second ...


Physician-Pharmacist Communication: Quotes, Quandaries And Quality, Nicholas E. Hagemeier Feb 2018

Physician-Pharmacist Communication: Quotes, Quandaries And Quality, Nicholas E. Hagemeier

Nicholas E. Hagemeier

No abstract provided.


In-House Daily Consensus Conference: An Important Quality Control/Quality Assurance Activity--Experience At A Major Referral Center., Amna Khurshid, Zubair Ahmad, Asim Qureshi May 2017

In-House Daily Consensus Conference: An Important Quality Control/Quality Assurance Activity--Experience At A Major Referral Center., Amna Khurshid, Zubair Ahmad, Asim Qureshi

Zubair Ahmad

Background:For every practicing histopathologist, improvement of diagnostic accuracy is an important objective. Personal consults are an important component of quality control (QC)/quality assurance (QA) in our Section of Histopathology. In addition, the College of American Pathologists recommends a daily in-house consensus conference, which is a prospective system by which all difficult and problematic cases are reviewed and discussed and signed out by consensus. Design: In-house consensus conference is held daily using a multi-headed microscope. This collegial session is run by the seniormost consultant in the section and is attended by all histopathology consultants and residents. The consultants and ...


Treat The Cause: Evidence-Based Practice, James M. Rippe, Michael Greger, David L. Katz, John H. Kelly, Margaret Moore, Darren Morton Apr 2017

Treat The Cause: Evidence-Based Practice, James M. Rippe, Michael Greger, David L. Katz, John H. Kelly, Margaret Moore, Darren Morton

Darren Morton

Darren was invited by the board of the American College of Lifestyle Medicine to represent the Australasian Lifestyle Medicine perspective on the opening panel of the 2014 American College of Lifestyle Medicine conference in San Diego (Nov, 2014). The dialogue, intended for an international audience, was later published as the mentioned journal article.


The Transcriptional Response To Oxidative Stress During Vertebrate Development: Effects Of Tert-Butylhydroquinone And 2,3,7,8-Tetrachlorodibenzo-P-Dioxin, Mark E. Hahn, Andrew G. Mcarthur, Sibel I. Karchner, Diana G. Franks, Matthew J. Jenny, Alicia R. Timme-Laragy, John J. Stegeman, Bruce R. Woodin, Michael J. Cipriano, Elwood Linney Dec 2016

The Transcriptional Response To Oxidative Stress During Vertebrate Development: Effects Of Tert-Butylhydroquinone And 2,3,7,8-Tetrachlorodibenzo-P-Dioxin, Mark E. Hahn, Andrew G. Mcarthur, Sibel I. Karchner, Diana G. Franks, Matthew J. Jenny, Alicia R. Timme-Laragy, John J. Stegeman, Bruce R. Woodin, Michael J. Cipriano, Elwood Linney

Alicia R. Timme-Laragy

Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis and to cardiovascular and neurodegenerative diseases. Developing animals may be especially sensitive to chemicals causing oxidative stress. The developmental expression and inducibility of anti-oxidant defenses through activation of NF-E2-related factor 2 (NRF2) affect susceptibility to oxidants, but the embryonic response to oxidants is not well understood. To assess the response to chemically mediated oxidative stress and how it may vary during development, zebrafish embryos, eleutheroembryos, or larvae at 1, 2, 3, 4, 5, and 6 days post fertilization (dpf) were exposed to DMSO (0.1%), tert-butylhydroquinone (tBHQ; 10 ...


Healthcare-Associated Infections: Getting The Balance Right In Safety And Quality V. Public Reporting, Brett G. Mitchell Oct 2016

Healthcare-Associated Infections: Getting The Balance Right In Safety And Quality V. Public Reporting, Brett G. Mitchell

Brett Mitchell

Healthcare settings are dangerous places. For those receiving care, the risk of unintended harm from healthcare failures continues to be significant. Given this, there is a need to monitor standards in healthcare, not only to identify potential issues, but also to plan and evaluate interventions aimed at improving healthcare standards. Public reporting of performance standards is one aspect to monitoring standards, but not the only one. Public reporting also brings with it challenges. This perspective explores the recent move to publicly report one healthcare-associated infection (HAI) on the MyHospitals website and comments on the broader issue of using existing HAI ...


Evaluation Of Student Nurses' Perception Of Preparedness For Oral Medication Administration In Clinical Practice: A Collaborative Study, Christina Aggar, Sonja Dawson Oct 2016

Evaluation Of Student Nurses' Perception Of Preparedness For Oral Medication Administration In Clinical Practice: A Collaborative Study, Christina Aggar, Sonja Dawson

Sonja Dawson

Background Attainment of oral medication administration skills and competency for student nurses is challenging and medication errors are common. The ability of nurses to master a clinical skill is dependent upon educational instruction and practice. Objectives The aim of this study was to evaluate nursing students' perception of preparedness for oral medication administration in two practice environments and determine possible relationship between student demographics and their perceived preparedness for oral medication administration. Design This was a cross sectional, exploratory study. Participants Eighty-eight second year students from a baccalaureate nursing course from two metropolitan Australian tertiary institutions participated. Methods Student nurses ...


Advancing Drug Delivery Systems For The Treatment Of Multiple Sclerosis, I. Tabansky, M. D. Messina, C. Bangeranye, J. Goldstein, K. M. Blitz-Shabbir, S. Machado, V. Jeganathan, P. Wright, S. Najjar, J. N. Stern Sep 2016

Advancing Drug Delivery Systems For The Treatment Of Multiple Sclerosis, I. Tabansky, M. D. Messina, C. Bangeranye, J. Goldstein, K. M. Blitz-Shabbir, S. Machado, V. Jeganathan, P. Wright, S. Najjar, J. N. Stern

Joel N.H. Stern

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. It is characterized by demyelination of neurons and loss of neuronal axons and oligodendrocytes. In MS, auto-reactive T cells and B cells cross the blood-brain barrier (BBB), causing perivenous demyelinating lesions that form multiple discrete inflammatory demyelinated plaques located primarily in the white matter. In chronic MS, cortical demyelination and progressive axonal transections develop. Treatment for MS can be stratified into disease-modifying therapies (DMTs) and symptomatic therapy. DMTs aim to decrease circulating immune cells or to prevent these cells from crossing the BBB and reduce the ...


A Pilot Study Of Deaf Trauma Survivors’ Experiences: Early Traumas Unique To Being Deaf In A Hearing World, Melissa L. Anderson, Kelly S. Wolf Craig, Wyatte C. Hall, Douglas M. Ziedonis Jul 2016

A Pilot Study Of Deaf Trauma Survivors’ Experiences: Early Traumas Unique To Being Deaf In A Hearing World, Melissa L. Anderson, Kelly S. Wolf Craig, Wyatte C. Hall, Douglas M. Ziedonis

Melissa L. Anderson

Conducting semi-structured American Sign Language interviews with 17 Deaf trauma survivors, this pilot study explored Deaf individuals’ trauma experiences and whether these experiences generally align with trauma in the hearing population. Most commonly reported traumas were physical assault, sudden unexpected deaths, and “other” very stressful events. Although some “other” events overlap with traumas in the general population, many are unique to Deaf people (e.g., corporal punishment at oral/aural school if caught using sign language, utter lack of communication with hearing parents). These findings suggest that Deaf individuals may experience developmental traumas distinct to being raised in a hearing ...


Bilateral Renal Artery Thrombosis Secondary To Blunt Trauma: Case Report And Review Of The Literature., P Frassinelli, Michael D. Pasquale Md, Facs, Fccm, C Reckard, J Goodreau, G Sherwin Jun 2016

Bilateral Renal Artery Thrombosis Secondary To Blunt Trauma: Case Report And Review Of The Literature., P Frassinelli, Michael D. Pasquale Md, Facs, Fccm, C Reckard, J Goodreau, G Sherwin

Michael D Pasquale MD, FACS, FCCM

No abstract provided.


Gender Differences In Cognitive Deficits In Schizophrenia With And Without Diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, Xu-Feng Huang Jun 2016

Gender Differences In Cognitive Deficits In Schizophrenia With And Without Diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, Xu-Feng Huang

Xu-Feng Huang

This study investigated gender differences in cognition in schizophrenia with and without diabetes. Cognition was assessed in 263 individuals with schizophrenia with age range (40-68): 67 males and 34 females with schizophrenia with diabetes; and 125 males and 37 females with schizophrenia without diabetes according to the repeatable battery for the assessment of neuropsychological status (RBANS). Fasting glucose, hemoglobin A1c (HbA1c) and lipid levels were measured. Results showed that male individuals performed worse on most cognitive tasks, especially attention, in schizophrenia with than without diabetes. This result was not observed in female individuals. Also, individuals of both genders showed higher ...


Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu Jun 2016

Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu

Xu-Feng Huang

Purpose: Leptin inhibits feeding and increases energy expenditure through the central nervous system. High-fat diet with saturated fatty acids (SFA) or n-6 polyunsaturated fatty acids (n-6 PUFA) has been reported to induce central leptin resistance and obesity. However, little is known if central administration of SFA or n-6 PUFA can reduce central leptin sensitivity. This study examined the central leptin sensitivity in response to intracerebroventricular (i.c.v.) injection of SFA, palmitic acid (PA) and n-6 PUFA, arachidonic acid (ARA) in mice. Methods: After overnight fasting, C57BL/6J male mice (n=24/group) were i.c.v. injected with either ...


Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin Jun 2016

Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin

Xu-Feng Huang

Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC ...


A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang Jun 2016

A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang

Xu-Feng Huang

The neuregulin 1 gene has repeatedly been identified as a susceptibility gene for schizophrenia, thus mice with genetic mutations in this gene offer a valuable tool for studying the role of neuregulin 1 in schizophrenia-related neurotransmission. In this study, slide-based receptor autoradiography was used to quantify glutamatergic N-methyl-d-aspartate (NMDA), dopaminergic D2, cannabinoid CB1 and acetylcholine M1/4 receptor levels in the brains of male heterozygous transmembrane domain neuregulin 1 mutant (Nrg1+/−) mice at two ages. Mutant mice expressed small but significant increases in NMDA receptor levels in the cingulate cortex (7%, p = 0.044), sensory cortex (8%, p = 0.024 ...


Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng Jun 2016

Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng

Xu-Feng Huang

Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models ...


Altered Il-2, Il-6 And Il-8 Serum Levels In Schizophrenia Patients With Tardive Dyskinesia, Hui-Mei An, Yun Long Tan, Jing Shi, Zhi-Ren Wang, Jair C. Soars, Jing Qin Wu, Fu-De Yang, Xu-Feng Huang, Xiang Yang Zhang Jun 2016

Altered Il-2, Il-6 And Il-8 Serum Levels In Schizophrenia Patients With Tardive Dyskinesia, Hui-Mei An, Yun Long Tan, Jing Shi, Zhi-Ren Wang, Jair C. Soars, Jing Qin Wu, Fu-De Yang, Xu-Feng Huang, Xiang Yang Zhang

Xu-Feng Huang

Immune deregulation has been postulated to be one of the mechanisms underlying the pathogenesis of tardive dyskinesia (TD). We hypothesized that interleukins would have a link with TD in schizophrenia patients. In this study, the serum IL-2, IL-6 and IL-8 levels were examined by enzyme-linked immunosorbent assay (ELISA) in schizophrenia patients with TD (n = 48) and without TD (n = 45), and healthy controls (n = 44). The psychopathological symptoms of schizophrenia were assessed by the Positive and Negative Syndrome Scale (PANSS). The severity of TD was evaluated using Abnormal Involuntary Movement Scale (AIMS). The results showed that serum IL-2, IL-6 and ...


Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin Jun 2016

Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin

Xu-Feng Huang

Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC ...


Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng Jun 2016

Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng

Xu-Feng Huang

Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models ...


An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell Jun 2016

An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell

Xu-Feng Huang

Purpose: Metabotropic glutamate receptors (mGluRs) are proposed novel therapeutic targets for a variety of brain disorders such as schizophrenia (SZ), bipolar disorder (BP) and major depression (MD). Despite their potential, the involvement of these receptors in these pathological processes is uncertain. This information is crucial to understand the efficiency of drugs that target these receptors. Methods: Using post-mortem human brains, mGluR2/3 and mGluR5 binding densities were measured in the anterior cingulate cortex of SZ, BP, MD and matched controls (CT) (n=15/group) by receptor autoradiography. Results: Whilst preliminary analyses indicated no diagnostic effect in mGluR2/3 or mGluR5 ...


A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang Jun 2016

A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang

Xu-Feng Huang

The neuregulin 1 gene has repeatedly been identified as a susceptibility gene for schizophrenia, thus mice with genetic mutations in this gene offer a valuable tool for studying the role of neuregulin 1 in schizophrenia-related neurotransmission. In this study, slide-based receptor autoradiography was used to quantify glutamatergic N-methyl-d-aspartate (NMDA), dopaminergic D2, cannabinoid CB1 and acetylcholine M1/4 receptor levels in the brains of male heterozygous transmembrane domain neuregulin 1 mutant (Nrg1+/−) mice at two ages. Mutant mice expressed small but significant increases in NMDA receptor levels in the cingulate cortex (7%, p = 0.044), sensory cortex (8%, p = 0.024 ...


Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng Jun 2016

Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng

Xu-Feng Huang

Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models ...


Regional Campuses And Long Distance Relationships: Making Them Work, Robert D. Barraco Md, Mph, Margaret A. Hadinger Edd, Ms, M. Edwyn Harrison Md, Joseph M. Kaczmarczyk Do, Mph Jun 2016

Regional Campuses And Long Distance Relationships: Making Them Work, Robert D. Barraco Md, Mph, Margaret A. Hadinger Edd, Ms, M. Edwyn Harrison Md, Joseph M. Kaczmarczyk Do, Mph

Margaret A. Hadinger, EdD, MS

No abstract provided.


The Incidence Of Falls In Intensive Care Survivors, Shane M. Patman, Diane Dennis, Kylie Hill Jun 2016

The Incidence Of Falls In Intensive Care Survivors, Shane M. Patman, Diane Dennis, Kylie Hill

Shane Patman

Background: Falling among adults in acute care is an important problem with falls rates in tertiary hospitals ranging from 2% to 5%. Factors that increase the risk of falling, such as advanced age, altered mental status, medications that act on the central nervous system and poor mobility, often characterise individuals who survive a prolonged intensive care unit (ICU) admission.

Purpose: To measure the incidence of falls and describe the characteristics of fallers among intensive care survivors.

Methods: A comprehensive retrospective chart review was undertaken of 190 adults who were intubated and ventilated for ≥168 h and survived their acute care ...


Intensive Care Unit Mobility Practices In Australia And New Zealand: A Point Prevalence Study, Susan C. Berney, Megan Harrold, Steven A. Webb, Ian Seppelt, Shane Patman, Peter J. Thomas, Linda Denehy Jun 2016

Intensive Care Unit Mobility Practices In Australia And New Zealand: A Point Prevalence Study, Susan C. Berney, Megan Harrold, Steven A. Webb, Ian Seppelt, Shane Patman, Peter J. Thomas, Linda Denehy

Shane Patman

Objectives:

To develop a comprehensive set of items describing physiotherapy mobilisation practices for critically ill patients, and to document current practices in intensive care units in Australia and New Zealand, focusing on patients having > 48 hours of mechanical ventilation.

Design:

Prospective, observational, multicentre, single-day, point prevalence study.

Participants and Setting:

All patients in 38 Australian and New Zealand ICUs at 10 am on one of three designated days in 2009 and 2010.

Main Outcome Measures:

Demographic data, admission diagnosis and mobilisation practices that had occurred in the previous 24 hours.

Results:

514 patients were enrolled, with 498 complete datasets. Mean ...


Seeing It Helps: Movement-Related Back Pain Is Reduced By Visualization Of The Back During Movement, Benedict M. Wand, Verity M. Tulloch, Pamela J. George, Anne J. Smith, Roger Goucke, Neil E. O'Connell, G Lorimer Moseley Jun 2016

Seeing It Helps: Movement-Related Back Pain Is Reduced By Visualization Of The Back During Movement, Benedict M. Wand, Verity M. Tulloch, Pamela J. George, Anne J. Smith, Roger Goucke, Neil E. O'Connell, G Lorimer Moseley

Pamela George

Objectives: The aim of this study was to determine whether visualization of the back influenced parameters of movement-related pain in people with chronic nonspecific low back pain. Methods: We used a randomized cross-over experiment in which 25 participants performed repeated lumbar spine movements under 2 conditions. In the visual feedback condition, patients were able to visualize their back as it moved by the use of mirrors. In the control condition, the mirror was covered so no visualization of the back was possible. Results: The average postmovement pain intensity after participants had moved with visual feedback was less (35.5+/-22 ...