Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2002

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1 - 30 of 1383

Full-Text Articles in Medicine and Health Sciences

Differential Modulation Of Signaling Pathways And Apoptosis Of Ras-Transformed 10t1/2 Cells By The Depsipeptide Fr901228, Kellie Fecteau, J Mei, Hwa-Chain Wang Jun 2014

Differential Modulation Of Signaling Pathways And Apoptosis Of Ras-Transformed 10t1/2 Cells By The Depsipeptide Fr901228, Kellie Fecteau, J Mei, Hwa-Chain Wang

Kellie Fecteau

(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,19,22-pentanone (FR901228), a natural anticancer depsipeptide, induces apoptosis of ras-transformed 10T1/2 cells whereas it induces growth arrest of nontransformed counterpart cells in G0/G1 phase of the cell cycle. Our study of the effect of FR901228 treatment on intracellular signaling pathways reveals a discriminating activity of FR901228 to regulate signaling cascades differently in ras-transformed 10T1/2 cells and nontransformed counterpart cells. Induction of apoptosis of ras-transformed cells by FR901228 correlates with suppression of the extracellular signal-regulated kinase (ERK ...


The Novel Presenilin-1-Associated Protein Is A Proapoptotic Mitochondrial Protein, Xuemin Xu, Yc Shi, W Gao, G Mao, G Zhao, S Agrawal, Gm Chisolm, D Sui, Mei-Zhen Cui Jun 2013

The Novel Presenilin-1-Associated Protein Is A Proapoptotic Mitochondrial Protein, Xuemin Xu, Yc Shi, W Gao, G Mao, G Zhao, S Agrawal, Gm Chisolm, D Sui, Mei-Zhen Cui

Mei-Zhen Cui

Recent studies have suggested a possible role for presenilin proteins in apoptotic cell death observed in Alzheimer's disease. The mechanism by which presenilin proteins regulate apoptotic cell death is not well understood. Using the yeast two-hybrid system, we previously isolated a novel protein, presenilin-associated protein (PSAP) that specifically interacts with the C terminus of presenilin 1 (PS1), but not presenilin 2 (PS2). Here we report that PSAP is a mitochondrial resident protein sharing homology with mitochondrial carrier protein. PSAP was detected in a mitochondria-enriched fraction, and PSAP immunofluorescence was present in a punctate pattern that colocalized with a mitochondrial ...


Income Inequality And Family Income And Their Relationships To Chronic Medical Conditions And Mental Health Disorders, Roland Sturm, Carole Gresenz Jan 2013

Income Inequality And Family Income And Their Relationships To Chronic Medical Conditions And Mental Health Disorders, Roland Sturm, Carole Gresenz

Roland Sturm

No abstract provided.


Integration Of Pbl In A Veterinary Medical Curriculum: First-Year Experiences With Application-Based Learning Exercises At The University Of Tennessee College Of Veterinary Medicine, Nancy Howell, India Lane, James Brace, Rm Shull Jul 2012

Integration Of Pbl In A Veterinary Medical Curriculum: First-Year Experiences With Application-Based Learning Exercises At The University Of Tennessee College Of Veterinary Medicine, Nancy Howell, India Lane, James Brace, Rm Shull

James J Brace

In 1999 problem-based learning experiences were introduced into the professional curriculum at the University of Tennessee College of Veterinary Medicine as part of an overall curricular modification. Problem-based learning (PBL) was introduced into the traditional curricular format in dedicated week-long experiences (Application-Based Learning Exercises) at specific points during the first six semesters. Methods to assess the success of this integration and other curricular changes included ongoing program assessment throughout the implementation of the modified curriculum. Program assessment engaged faculty facilitators and students, who were involved in a process unfamiliar to both. Results of preliminary assessment indicate mostly positive reaction to ...


Effects Of Dehydration Mediums And Temperature On Total Dehydration Time And Tissue Shrinkage, Ma Brown, Robert Reed, Robert Henry Jul 2012

Effects Of Dehydration Mediums And Temperature On Total Dehydration Time And Tissue Shrinkage, Ma Brown, Robert Reed, Robert Henry

Robert B. Reed, Jr., DVM, Ph.D.

To assess the efficacy of current popular plastination dehydration techniques, a variety of organs were dehydrated to: 1. Determine the minimal length of time necessary to thoroughly dehydrate specimens for impregnation and 2. Measure tissue shrinkage during dehydration. Dehydrating agents commonly used for plastination (both room and cold temperature acetone and room temperature methanol) were evaluated. Cold acetone dehydration produced the least amount of tissue shrinkage. Shrinkage was greatest in the graded methanol series. Minimal length of time necessary for acetone dehydration was five days for both cold and room-temperature acetone dehydration.


Integration Of Pbl In A Veterinary Medical Curriculum: First-Year Experiences With Application-Based Learning Exercises At The University Of Tennessee College Of Veterinary Medicine, Nancy Howell, India Lane, James Brace, Rm Shull Apr 2012

Integration Of Pbl In A Veterinary Medical Curriculum: First-Year Experiences With Application-Based Learning Exercises At The University Of Tennessee College Of Veterinary Medicine, Nancy Howell, India Lane, James Brace, Rm Shull

India F. Lane

In 1999 problem-based learning experiences were introduced into the professional curriculum at the University of Tennessee College of Veterinary Medicine as part of an overall curricular modification. Problem-based learning (PBL) was introduced into the traditional curricular format in dedicated week-long experiences (Application-Based Learning Exercises) at specific points during the first six semesters. Methods to assess the success of this integration and other curricular changes included ongoing program assessment throughout the implementation of the modified curriculum. Program assessment engaged faculty facilitators and students, who were involved in a process unfamiliar to both. Results of preliminary assessment indicate mostly positive reaction to ...


Detection Of Feline Coronavirus In Captive Felidae In The Usa, Melissa Kennedy, S Citino, A Mcnabb, A Moffatt, K Gertz, Stephen Kania Mar 2012

Detection Of Feline Coronavirus In Captive Felidae In The Usa, Melissa Kennedy, S Citino, A Mcnabb, A Moffatt, K Gertz, Stephen Kania

Stephen A Kania

Feline coronavirus (FCoV) is an important pathogen of domestic and nondomestic Felidae. Investigation into the prevalence of FCoV in exotic Felidae has relied primarily on serology. The usefulness of genetic detection of FCoV using reverse transcription and nested polymerase chain reaction (RT/nPCR) for viral screening was investigated. Seventy-five biologic samples, primarily feces, from captive felids from 11 institutions were tested using PCR. Serum samples collected from all but 12 of these animals were tested for antibodies to type I and type II FCoV by indirect immunofluorescence. Twenty-four animals were positive using RT/nPCR for virus. Twenty-nine animals were seropositive ...


Effect Of Deracoxib, A New Cox-2 Inhibitor, On The Prevention Of Lameness Induced By Chemical Synovitis In Dogs, Darryl Millis, Joseph Weigel, Tamberlyn Moyers, Francis Buonomo Feb 2012

Effect Of Deracoxib, A New Cox-2 Inhibitor, On The Prevention Of Lameness Induced By Chemical Synovitis In Dogs, Darryl Millis, Joseph Weigel, Tamberlyn Moyers, Francis Buonomo

Darryl L. Millis

Twenty-four healthy, mixed-breed hound-type dogs were evenly and randomly assigned to a placebo control group, one of four dosages of deracoxib (0.3, 1, 3, or 10 mg/kg), or carprofen (2.2 mg/kg). Oral dosing of placebo, carprofen, or deracoxib was done 30 minutes before intraarticular injection of urate crystal suspension for induction of synovitis. Ground reaction forces, subjective clinical lameness scores, pain, joint effusion, and quantitative pain threshold responses were measured in a blinded fashion before induction of synovitis and 2, 4, 6, 8, 12, and 24 hours after injection. The medium and high dosages of deracoxib ...


Case Report- Urethrovaginal Fistula In A Llama, Tulio Prado, G Morgan, Maria Prado, R Bahr, R Streeter Jan 2012

Case Report- Urethrovaginal Fistula In A Llama, Tulio Prado, G Morgan, Maria Prado, R Bahr, R Streeter

Maria E. Prado MV, Ph.D, DACVIM-LA

No abstract provided.


The Effect Of Tiletamine And Zolazepam On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, Barton Rohrbach, L Ross, H Schultz Aug 2011

The Effect Of Tiletamine And Zolazepam On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, Barton Rohrbach, L Ross, H Schultz

Thomas J Doherty

This study was conducted in 6 healthy goats (1-3-years-old) and anaesthesia was induced using isoflurane delivered via a mask. ~1 h after induction to anaesthesia, and with the end-tidal isoflurane concentration held constant for at least 20 min. Following baseline isoflurane minimum alveolar concentration (MAC) determination, tiletamine and zolazepam (TZ) (0.55, 1.1, 2.2, 4.4 or 8.8 mg/kg) or saline were administered i.v. in an unmasked, 6*6 Latin square design. Goats received each of the 6 treatments, in a random order, with a 7-day washout period between treatments. Response to treatment was defined ...


Effect Of Acepromazine And Butorphanol On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, Barton Rohrbach, Dennis Geiser Aug 2011

Effect Of Acepromazine And Butorphanol On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, Barton Rohrbach, Dennis Geiser

Thomas J Doherty

It was hypothesized that acepromazine and butorphanol would reduce the isoflurane minimum alveolar concentration (MAC) in goats when compared with a saline treatment. Following baseline isoflurane MAC determination in six healthy adult goats, the animals were randomly assigned to receive one of six treatments: intravenous administration of acepromazine at 0.025, 0.05 or 0.1 mg/kg; i.v. administration of butorphanol at 0.05 or 0.1 mg/kg; and i.v. administration of saline. Results show that isoflurane MAC in goats decreased between 36 and 45%, following the i.v. administration of acepromazine. Also, the results indicate ...


A Comparison Of The Mechanical Strength Of Two Stapled Anastomosis Techniques For Equine Small Intestine, R Bickers, James Blackford, Hugo Eiler, Barton Rohrbach Jul 2011

A Comparison Of The Mechanical Strength Of Two Stapled Anastomosis Techniques For Equine Small Intestine, R Bickers, James Blackford, Hugo Eiler, Barton Rohrbach

James T. Blackford DVM, MS, DACVS

Objective: To compare bursting strength, time of construction, and cost of a closed one-stage, stapled functional end-to-end jejunojejunostomy (FEE) with a stapled side-to-side jejunojejunostomy (STS). Study Design: Experimental, randomized block design. Animals: Seven adult horses without gastrointestinal disease. Methods: The jejunum was isolated, and three FEE, three STS, and three control segments were created in each horse using a randomized block design. Anastomosis time was recorded. The intraluminal pressure at failure and mode of failure were recorded. Length at failure was measured on digitized images. Bursting pressure (BP), bursting wall tension (BWT), anastomosis time, and cost were compared. Results: Control ...


Effect Of Acepromazine And Butorphanol On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, Barton Rohrbach, Dennis Geiser Oct 2010

Effect Of Acepromazine And Butorphanol On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, Barton Rohrbach, Dennis Geiser

Dennis R. Geiser DVM, DAVBP

It was hypothesized that acepromazine and butorphanol would reduce the isoflurane minimum alveolar concentration (MAC) in goats when compared with a saline treatment. Following baseline isoflurane MAC determination in six healthy adult goats, the animals were randomly assigned to receive one of six treatments: intravenous administration of acepromazine at 0.025, 0.05 or 0.1 mg/kg; i.v. administration of butorphanol at 0.05 or 0.1 mg/kg; and i.v. administration of saline. Results show that isoflurane MAC in goats decreased between 36 and 45%, following the i.v. administration of acepromazine. Also, the results indicate ...


An Investigation Of The Interest For A Nurse Re-Entry Program In Southeastern Ohio, Marsha K. Rodgers Dec 2002

An Investigation Of The Interest For A Nurse Re-Entry Program In Southeastern Ohio, Marsha K. Rodgers

Theses, Dissertations and Capstones

In the United States and throughout the world there is a serious concern in the growing nursing shortage. Many recruitment and retention techniques are currently being used to ease the nursing shortage. One such avenue is a nurse re-entry program. The primary purpose of this study was to determine the interest for a RN re-entry program in southeastern Ohio.

The data collected during the investigation used both qualitative and quantitative research techniques. Information was received through two survey questionnaires and two focus groups. The instruments were designed with the purpose of determining how many registered nurses were not working in ...


Effect Of Assessment Method On The Discrepancy Between Judgments Of Health Disorders People Have And Do Not Have: A Web Study, Jonathan Baron, David A. Asch, Angela Fagerlin, Christopher A. Jepson, George Loewenstein, Jason Riis, Margaret G. Stineman, Peter A. Ubel Dec 2002

Effect Of Assessment Method On The Discrepancy Between Judgments Of Health Disorders People Have And Do Not Have: A Web Study, Jonathan Baron, David A. Asch, Angela Fagerlin, Christopher A. Jepson, George Loewenstein, Jason Riis, Margaret G. Stineman, Peter A. Ubel

Marketing Papers

Three experiments on the World Wide Web asked subjects to rate the severity of common health disorders such as acne or arthritis. People who had a disorder (“Haves”) tended to rate it as less severe than people who did not have it (“Not-haves”). Two explanations of this Have versus Not-have discrepancy were rejected. By one account, people change their reference point when they rate a disorder that they have. More precise reference points would, on this account, reduce the discrepancy, but, if anything, the discrepancy was larger. By another account, people who do not have the disorder focus on attributes ...


Viability Of A Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights For Better Antiviral Therapy, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Nancy M. King, Celia A. Schiffer Dec 2002

Viability Of A Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights For Better Antiviral Therapy, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Nancy M. King, Celia A. Schiffer

Open Access Articles

Under the selective pressure of protease inhibitor therapy, patients infected with human immunodeficiency virus (HIV) often develop drug-resistant HIV strains. One of the first drug-resistant mutations to arise in the protease, particularly in patients receiving indinavir or ritonavir treatment, is V82A, which compromises the binding of these and other inhibitors but allows the virus to remain viable. To probe this drug resistance, we solved the crystal structures of three natural substrates and two commercial drugs in complex with an inactive drug-resistant mutant (D25N/V82A) HIV-1 protease. Through structural analysis and comparison of the protein-ligand interactions, we found that Val82 interacts ...


Regulation Of Rac1 Activation By The Low Density Lipoprotein Receptor–Related Protein, Zhong Ma, Keena S. Thomas, Donna J. Webb, Radim Moravec, Ana Maria Salicioni, Wendy M. Mars, Steven L. Gonias Dec 2002

Regulation Of Rac1 Activation By The Low Density Lipoprotein Receptor–Related Protein, Zhong Ma, Keena S. Thomas, Donna J. Webb, Radim Moravec, Ana Maria Salicioni, Wendy M. Mars, Steven L. Gonias

Ana Maria Salicioni

The low density lipoprotein receptor–related protein (LRP-1) binds and mediates the endocytosis of multiple ligands, transports the urokinase-type plasminogen activator receptor (uPAR) and other membrane proteins into endosomes, and binds intracellular adaptor proteins involved in cell signaling. In this paper, we show that in murine embryonic fibroblasts (MEFs) and L929 cells, LRP-1 functions as a major regulator of Rac1 activation, and that this activity depends on uPAR. LRP-1–deficient MEFs demonstrated increased Rac1 activation compared with LRP-1–expressing MEFs, and this property was reversed by expressing the VLDL receptor, a member of the same gene family as LRP-1, with ...


Autoantibodies To Centrosomes Are Diagnostic For Human Scleroderma And Can Be Induced By Experimental Mycoplasma Infection In Mice: A Dissertation, Irina Catrinel Gavanescu Dec 2002

Autoantibodies To Centrosomes Are Diagnostic For Human Scleroderma And Can Be Induced By Experimental Mycoplasma Infection In Mice: A Dissertation, Irina Catrinel Gavanescu

GSBS Dissertations and Theses

The overall objective of this thesis work was to develop new insights into the etiology of scleroderma, a human systemic autoimmune disease, by analyzing the autoantibodies to centrosome antigens that develop during the disease. Centrosomes are perinuclear organelles that form microtubule arrays, including mitotic spindles that ensure the faithful segregation of chromosomes during mitosis.

These studies used a novel methodology to determine the prevalence of anti-centrosome autoantibodies in patients with scleroderma. Recombinant centrosome antigens were used to determine the antigenic specificity of anti-centrosome antibody subsets by immunoblotting. Centrosome marker antibodies were used in indirect immunofluorescence assays to distinguish centrosomes within ...


Method For Inhibition Of Photocarcinogenesis Or Photoimmunosuppression Using Niacin, Elaine L. Jacobson, Helen L. Gensler Dec 2002

Method For Inhibition Of Photocarcinogenesis Or Photoimmunosuppression Using Niacin, Elaine L. Jacobson, Helen L. Gensler

Graduate Center for Nutritional Sciences Faculty Patents

The invention is directed to novel methods for the suppression of photocarcinogenesis and photoimmunosuppression in mice. The novel methods comprises the step of administering to a subject a pharmaceutical composition comprising niacin and a pharmaceutical carrier.


Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks Dec 2002

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.


Migrant Worker Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center Dec 2002

Migrant Worker Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On September 13, 2002, a 26 year-old male Hispanic migrant worker (decedent) died when the tractor he was driving on a country roadway overturned. The decedent had experience driving the tractor in a field, but did not have experience driving it on a public roadway. On the afternoon of the incident, the decedent drove the tractor, pulling a wagonload of tobacco, from the farm where it had been harvested to the tobacco barn one mile away. The road was hilly and had a sharp curve to the right at the bottom of the hill. As the decedent drove the tractor ...


Screening At Worksite Applying The Framingham Heart Study Score., Paulo A. Lotufo Dec 2002

Screening At Worksite Applying The Framingham Heart Study Score., Paulo A. Lotufo

Paulo A Lotufo

The first evaluation of class of occupation and cardiovascular risk factors in a Brazilian sample of civil servants. 1) context: Cardiovascular diseases are the main causes of death in Brazil. The high-risk approach to cardiovascular risk factors by screening test at worksite is one possible strategy of prevention. 2) objective: to verify the impact of a risk factors screening according to occupational levels. 3) type of study: cross-sectional 4) setting: occupational division of University of Sao Paulo 5) participants: 6,587 employees aged 20 to 69 years-old classified according three occupational grades (non-skilled, both manual and non-manual jobs; technical; faculty ...


Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin Dec 2002

Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin

Electronic Theses and Dissertations

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated membrane K+ current. Patch-clamp electrophysiology and transwell migration assays were used to study the effects of HGF/SF on membrane K+ currents and cell migration in MDCK II cells. HGF/SF activated membrane K+ currents that increased over 24 hr, and these could be modulated by altering intracellular free calcium ...


Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson Dec 2002

Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson

Electronic Theses and Dissertations

Lithium continues to be widely prescribed for the management of bipolar disease, yet cognitive impairment-related side effects promote noncompliance of the treatment regimen. We have introduced a novel animal model, the black molly fish, to study dose-response effects of lithium on short-term (STM) and long-term (LTM) memories. We developed a method utilizing capillary ion analysis (CIA), to measure plasma and brain lithium levels employed in our behavioral studies. We then developed an appropriate testing environment to ascertain learning capacities of these fish. We established that black mollies could adequately perform a forced-choice spontaneous alternation (SA) task used extensively in rodents ...


The Novel Presenilin-1-Associated Protein Is A Proapoptotic Mitochondrial Protein, Xuemin Xu, Yc Shi, W Gao, G Mao, G Zhao, S Agrawal, Gm Chisolm, D Sui, Mei-Zhen Cui Dec 2002

The Novel Presenilin-1-Associated Protein Is A Proapoptotic Mitochondrial Protein, Xuemin Xu, Yc Shi, W Gao, G Mao, G Zhao, S Agrawal, Gm Chisolm, D Sui, Mei-Zhen Cui

Xuemin Xu

Recent studies have suggested a possible role for presenilin proteins in apoptotic cell death observed in Alzheimer's disease. The mechanism by which presenilin proteins regulate apoptotic cell death is not well understood. Using the yeast two-hybrid system, we previously isolated a novel protein, presenilin-associated protein (PSAP) that specifically interacts with the C terminus of presenilin 1 (PS1), but not presenilin 2 (PS2). Here we report that PSAP is a mitochondrial resident protein sharing homology with mitochondrial carrier protein. PSAP was detected in a mitochondria-enriched fraction, and PSAP immunofluorescence was present in a punctate pattern that colocalized with a mitochondrial ...


R&D Is How Best Companies Stay That Way, Rick Burton Dec 2002

R&D Is How Best Companies Stay That Way, Rick Burton

Sport Management

No abstract provided.


Activation And Role Of Memory Cd8 T Cells In Heterologous Antiviral Immunity And Immunopathology In The Lung: A Dissertation, Hong Chen Dec 2002

Activation And Role Of Memory Cd8 T Cells In Heterologous Antiviral Immunity And Immunopathology In The Lung: A Dissertation, Hong Chen

GSBS Dissertations and Theses

Each individual experiences many sequential infections throughout the lifetime. An increasing body of work indicates that prior exposure to unrelated pathogens can greatly alter the disease course during a later infection. This can be a consequence of a phenomenon known as heterologous immunity. Most viruses invade the host through the mucosa of a variety of organs and tissues. Using the intranasal mucosal route of infection, the thesis focused on studying modulation of lymphocytic choriomeningitis virus (LCMV)-specific memory CD8 T cells upon respiratory vaccinia virus (VV) infection and the role of these memory CD8 T cells in heterologous immunity against ...


Bonnie Sommerville Interview For The Miami Valley College Of Nursing And Health Oral History Project, Donna M. Curry, Carol Holdcraft, Bonnie Sommerville Dec 2002

Bonnie Sommerville Interview For The Miami Valley College Of Nursing And Health Oral History Project, Donna M. Curry, Carol Holdcraft, Bonnie Sommerville

Wright State University - Miami Valley College of Nursing and Health Oral History Project

Carol Holdcraft and Donna Miles Curry interviewed Bonnie Sommerville on December 3, 2002 about the founding of Wright State University College of Nursing and Health. In the interview, Sommerville discusses her career and her decision to come to Wright State as a student and faculty member for the College of Nursing and Health.


A New Immunoassay For Quantification Of A Novel Cancer Antigen In Serum And Immunostaining Of Carcinoma Tissues And Cultured Cells Revealing The Antigenic Cellular Location., Emily Christine Mcduffee Dec 2002

A New Immunoassay For Quantification Of A Novel Cancer Antigen In Serum And Immunostaining Of Carcinoma Tissues And Cultured Cells Revealing The Antigenic Cellular Location., Emily Christine Mcduffee

Electronic Theses and Dissertations

The purpose of this study is 1) to examine the presence of the antigen in serum by employing a newly developed ELISA immunoassay that quantifies the total antigen and bound antigen (antigen-antibody complex) using polyclonal chicken antibodies directed against an IgM-binding epitope of the new antigen, and 2) to determine the location of the antigen in carcinoma and normal cells. Sera from healthy volunteers (n = 147) and cancer patients (n = 26) were compared for both bound and total antigen concentrations using the new ELISA. Healthy volunteers were subdivided into three groups: those with a personal history of cancer (n = 13 ...


Factors Affecting Nurses' Preconceived Notions Towards Geriatric Clients, Patricia Krupski Dec 2002

Factors Affecting Nurses' Preconceived Notions Towards Geriatric Clients, Patricia Krupski

Master's Theses, Capstones, and Projects

With the geriatric population increasing and doubling by the year 2030, their health care needs are also increasing. However, preconceived notions of medical/surgical registered nurses about geriatrics clients may affect the way that the nursing staff will interact with geriatric clients. The purpose of this study was to examine the hypothesis: There is a relationship between selected demographic variables and preconceived notions of practicing medical/surgical registered nurses about geriatric clients. An e-mail questionnaire was sent to 150 State of Wisconsin licensed, practicing, medical/surgical registered nurses. This questionnaire included the Palmore's Facts of Aging Quiz 1 and ...