Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2010

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1 - 30 of 6820

Full-Text Articles in Medicine and Health Sciences

Health-Related Quality Of Life And Chronic Obstructive Pulmonary Disease In North Carolina, David Brown, Roy Pleasants, Jill Ohar, Monica Kraft, James Donohue, David Mannino, Winston Liao, Harry Herric Dec 2015

Health-Related Quality Of Life And Chronic Obstructive Pulmonary Disease In North Carolina, David Brown, Roy Pleasants, Jill Ohar, Monica Kraft, James Donohue, David Mannino, Winston Liao, Harry Herric

David C. Brown

Background:

Comparisons of health-related quality of life (HRQOL) between persons with chronic obstructive pulmonary disease (COPD) and adults in the general population are not well described.

Aims:

To examine associations between COPD and four measures of HRQOL in a population-based sample.

Patients & Methods:

These relationships were examined using data from 13,887 adults aged >18 years who participated in the 2007 Behavioral Risk Factor Surveillance System (BRFSS) conducted in North Carolina (NC). Logistic regression was used to obtain adjusted relative odds (aOR).

Results:

The age-adjusted prevalence of COPD among NC adults was 5.4% (standard error 0.27). Nearly half of adults with COPD reported fair/poor health compared with 15% of those without the condition (age-aOR, 5.5; 95% confidence interval [ CI] , 4.4 to 6.8). On average, adults with COPD reported twice as many unhealthy days (physical/mental) as those without the condition. The age-adjusted prevalence of >14 unhealthy days during the prior 30 days was 45% for adults with COPD and 17% for those without. The aOR of >14 unhealthy days was 1 ...


Chapter 5. Chronic Obstructive Pulmonary Disease (Copd), David Mannino, Janet Croft, David Brown Dec 2015

Chapter 5. Chronic Obstructive Pulmonary Disease (Copd), David Mannino, Janet Croft, David Brown

David C. Brown

No abstract provided.


In Vitro Haematopoiesis Of A Novel Dendritic-Like Cell Present In Murine Spleen, Jonathan Tan, Helen O'Neill Oct 2015

In Vitro Haematopoiesis Of A Novel Dendritic-Like Cell Present In Murine Spleen, Jonathan Tan, Helen O'Neill

Jonathan Tan

Abstract: Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for haematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell ...


Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill Sep 2015

Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill

Jonathan Tan

Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restricted in vitro development of only L-DC in these stromal cultures, we questioned whether self-renewing HSC or progenitors exist in spleen with restricted differentiative capacity for only L-DC. Neonatal spleen and BM were compared for their ability to reconstitute ...


For Faculty, By Faculty: A Case Study Of Learning To Teach Online, Trena Paulus, Carole Myers, Sandra Mixer, Tami Wyatt, Debra Lee, Jan Lee Jul 2015

For Faculty, By Faculty: A Case Study Of Learning To Teach Online, Trena Paulus, Carole Myers, Sandra Mixer, Tami Wyatt, Debra Lee, Jan Lee

Tami H Wyatt

The shortage of nursing faculty and the need for MSN-prepared faculty to have access to doctoral education and remain in their teaching roles has resulted in a growing number of nurse education programs moving online. A better understanding of how best to support faculty during this transition is needed. This case study describes the experiences of faculty at one institution as they participated in a grassroots effort to learn about online teaching. Six themes related to the faculty development experience were identified: 1) plugging in; 2) peer sharing, modeling and community building; 3) multidimensional learning; 4) role-shifting and meta-learning; 5 ...


For Faculty, By Faculty: A Case Study Of Learning To Teach Online, Trena Paulus, Carole Myers, Sandra Mixer, Tami Wyatt, Debra Lee, Jan Lee Jul 2015

For Faculty, By Faculty: A Case Study Of Learning To Teach Online, Trena Paulus, Carole Myers, Sandra Mixer, Tami Wyatt, Debra Lee, Jan Lee

Tami H Wyatt

The shortage of nursing faculty and the need for MSN-prepared faculty to have access to doctoral education and remain in their teaching roles has resulted in a growing number of nurse education programs moving online. A better understanding of how best to support faculty during this transition is needed. This case study describes the experiences of faculty at one institution as they participated in a grassroots effort to learn about online teaching. Six themes related to the faculty development experience were identified: 1) plugging in; 2) peer sharing, modeling and community building; 3) multidimensional learning; 4) role-shifting and meta-learning; 5 ...


Tear Volume, Turnover Rate, And Flow Rate In Ophthalmologically Normal Horses, Thomas Chen, Daniel Ward Apr 2015

Tear Volume, Turnover Rate, And Flow Rate In Ophthalmologically Normal Horses, Thomas Chen, Daniel Ward

Thomas Chen DVM, DACVO

No abstract provided.


Occupational Science: A Data-Based American Perspective, Doris Pierce, Karen Atler, Julie Baltisberger, Elaine Fehringer, Elizabeth Hunter, Somaya Malkawi, Twilia Parr Feb 2015

Occupational Science: A Data-Based American Perspective, Doris Pierce, Karen Atler, Julie Baltisberger, Elaine Fehringer, Elizabeth Hunter, Somaya Malkawi, Twilia Parr

Julie A. Baltisberger

The purpose of this research was to provide a data-based picture of the discipline of occupational science by identifying patterns of research in the first 5 years of presentations at the Society for the Study of Occupation: USA (SSO:USA). A grounded theory approach was used to examine 184 peer-reviewed presentation abstracts, from 2002 to 2006. Among the 108 data-based presentations, adults were the most studied group, with 46% of the data-based abstracts focused on participants with a disability or clear disadvantage. Presenters’ research foci related to 4 themes: the personal experience of occupation, the context surrounding or impacting occupation ...


(Invited) Instructor For Ce Class, “Nlm Pubmed/Medline Basics: Locating Hidden Treasures In Radiology”, Marilia Antunez Dec 2014

(Invited) Instructor For Ce Class, “Nlm Pubmed/Medline Basics: Locating Hidden Treasures In Radiology”, Marilia Antunez

Marilia Y. Antunez, MLS, MA

Also provided research assistance to radiologists attending the 2007, 2009, and 2010 RSNA Annual Conferences in English and Spanish.


Uterine Lesions In 32 Female Miniature Pet Pigs, Marcia Ilha, Shelley Newman, Sarel Van Amstel, Kellie Fecteau, Barton Rohrbach Jun 2014

Uterine Lesions In 32 Female Miniature Pet Pigs, Marcia Ilha, Shelley Newman, Sarel Van Amstel, Kellie Fecteau, Barton Rohrbach

Kellie Fecteau

Thirty-two 4-month-old to 19-year-old female miniature pet pigs were spayed. Uterine lesions were present in all except 8 pigs. The 24 remaining pigs had diffuse cystic endometrial hyperplasia, of which 14 had smooth muscle tumors, including leiomyomas and leiomyosarcomas, in the uterus or broad ligament. Nodular endometrial lesions—including adenocarcinomas, adenomas, and/or adenomyosis—were present in 10 pigs, 3 of which had concurrent smooth muscle tumors. Pyometra was present in 3 pigs. In uterine sections with cystic endometrial hyperplasia, adenomyosis, or adenomas, approximately 70% of epithelial nuclei expressed estrogen receptor and progesterone receptor immunohistochemically; in adenocarcinomas, expression was 20 ...


Comparison Of Chemistry Analytes Between Two Portable, Commercially-Available Analyzers And A Conventional Laboratory Analyzer In Reptiles, Sl Mccain, Bente Flatland, Juergen Schumacher, E Clarke, Michael Fry Mar 2014

Comparison Of Chemistry Analytes Between Two Portable, Commercially-Available Analyzers And A Conventional Laboratory Analyzer In Reptiles, Sl Mccain, Bente Flatland, Juergen Schumacher, E Clarke, Michael Fry

Bente Flatland

No abstract provided.


Instructional Design Portfolio: A Faculty Development Program For Nurse Educators Learning To Teach Online, Debra Lee, Trena Paulus, Iryna Loboda, Gina Phipps, Tami Wyatt, Carole Myers, Sandra Mixer Jul 2013

Instructional Design Portfolio: A Faculty Development Program For Nurse Educators Learning To Teach Online, Debra Lee, Trena Paulus, Iryna Loboda, Gina Phipps, Tami Wyatt, Carole Myers, Sandra Mixer

Tami H Wyatt

As the College of Nursing at the University of Tennessee, Knoxville prepared to move their graduate programs online, a nursing faculty grass-roots movement led to the implementation of a faculty development program. This instructional design portfolio describes the design, development, implementation, and evaluation of this program, with the goal of identifying best practices in the design of programs for learning to teach online. These include understanding the importance of just-in-time learning, developing the ability to meet diverse needs, defining workshop expectations and workload requirements, increased integration of technology and pedagogy training, and the importance of modeling.


Uterine Lesions In 32 Female Miniature Pet Pigs, Marcia Ilha, Shelley Newman, Sarel Van Amstel, Kellie Fecteau, Barton Rohrbach Jun 2013

Uterine Lesions In 32 Female Miniature Pet Pigs, Marcia Ilha, Shelley Newman, Sarel Van Amstel, Kellie Fecteau, Barton Rohrbach

Shelley Newman

Thirty-two 4-month-old to 19-year-old female miniature pet pigs were spayed. Uterine lesions were present in all except 8 pigs. The 24 remaining pigs had diffuse cystic endometrial hyperplasia, of which 14 had smooth muscle tumors, including leiomyomas and leiomyosarcomas, in the uterus or broad ligament. Nodular endometrial lesions—including adenocarcinomas, adenomas, and/or adenomyosis—were present in 10 pigs, 3 of which had concurrent smooth muscle tumors. Pyometra was present in 3 pigs. In uterine sections with cystic endometrial hyperplasia, adenomyosis, or adenomas, approximately 70% of epithelial nuclei expressed estrogen receptor and progesterone receptor immunohistochemically; in adenocarcinomas, expression was 20 ...


Effect Of Extracorporeal Shock Wave Therapy On Elbow Osteoarthritis In Dogs, Darryl Millis, Marti Drum, D Whitlock May 2013

Effect Of Extracorporeal Shock Wave Therapy On Elbow Osteoarthritis In Dogs, Darryl Millis, Marti Drum, D Whitlock

Darryl L. Millis

No abstract provided.


Mri Of Brain Disease In Veterinary Patients Part 2: Acquired Brain Disorders, Silke Hecht, William Adams Feb 2013

Mri Of Brain Disease In Veterinary Patients Part 2: Acquired Brain Disorders, Silke Hecht, William Adams

William H Adams, DVM, DACVR

Magnetic resonance imaging (MRI) has revolutionized brain imaging in veterinary medicine, making possible improved characterization of intracranial pathologic processes. This article focuses on MRI features of acquired brain disorders, including infectious inflammatory, noninfectious inflammatory, cerebrovascular, metabolic, nutritional, toxic, degenerative, traumatic, and neoplastic causes. Congenital intracranial disorders are covered in a companion article.


Mri Of Brain Disease In Veterinary Patients Part 1: Basic Principles And Congenital Brain Disorders, Silke Hecht, Williams Adams Feb 2013

Mri Of Brain Disease In Veterinary Patients Part 1: Basic Principles And Congenital Brain Disorders, Silke Hecht, Williams Adams

William H Adams, DVM, DACVR

Magnetic resonance imaging (MRI) is increasingly being used in the diagnosis of central nervous system disorders in veterinary patients and is quickly becoming the imaging modality of choice in evaluation of brain and intracranial disease. This article provides an overview of the basic principles of MRI, a description of sequences and their applications in brain imaging, and an approach to interpretation of brain MRI. A detailed discussion of imaging findings in general intracranial disorders including hydrocephalus, vasogenic edema, brain herniation, and seizure-associated changes, and the MR diagnosis of congenital brain disorders is provided. MRI evaluation of acquired brain disorders is ...


Motivational Interviewing (Mi) Using Co-Active Life Coaching Skills As A Treatment For Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow Jan 2013

Motivational Interviewing (Mi) Using Co-Active Life Coaching Skills As A Treatment For Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.


Inhibition Of Feline Herpesvirus 1 Replication In Vitro By Small Interfering Rnas, Rebecca Wilkes, Stephen Kania Oct 2012

Inhibition Of Feline Herpesvirus 1 Replication In Vitro By Small Interfering Rnas, Rebecca Wilkes, Stephen Kania

Rebecca P. Wilkes DVM, PhD, DACVM

OBJECTIVE: To evaluate the ability of 5 small interfering RNAs (siRNAs) targeting mRNA of the feline herpesvirus-1 (FHV-1) DNA polymerase gene to reduce in vitro viral replication and gene expression of FHV-1, to evaluate combinations of these siRNAs with siRNAs that target the glycoprotein D gene of FHV-1, and to determine the combination or combinations of siRNAs that yield the greatest inhibition of in vitro viral replication. SAMPLE POPULATION: Cultured Crandell-Rees feline kidney (CRFK) cells. PROCEDURES: CRFK cells were transfected with siRNAs designed to target mRNA of the FHV-1 DNA polymerase gene. Effective treatment was determined by quantification of the ...


Variability Of Estradiol Concentration In Normal Dogs, Linda Frank, Rebekah Mullins, Barton Rohrbach Aug 2012

Variability Of Estradiol Concentration In Normal Dogs, Linda Frank, Rebekah Mullins, Barton Rohrbach

Barton W Rohrbach Dr.

Estradiol concentrations are evaluated in canine serum as part of an adrenal panel used to diagnose atypical Cushing’s syndrome and other endocrine abnormalities. Estradiol concentrations are often elevated in dogs without clinical signs of hyperestrogenism, and the significance of this elevation is unknown. The purpose of this study was to estimate the variation in estradiol concentrations in normal dogs. Ten neutered male and female dogs were enrolled in the study. Blood was collected from each dog at 2 h intervals, four times during a given day. This was repeated approximately 1 (week 2) and 5 weeks later (week 6 ...


Uterine Lesions In 32 Female Miniature Pet Pigs, Marcia Ilha, Shelley Newman, Sarel Van Amstel, Kellie Fecteau, Barton Rohrbach Aug 2012

Uterine Lesions In 32 Female Miniature Pet Pigs, Marcia Ilha, Shelley Newman, Sarel Van Amstel, Kellie Fecteau, Barton Rohrbach

Barton W Rohrbach Dr.

Thirty-two 4-month-old to 19-year-old female miniature pet pigs were spayed. Uterine lesions were present in all except 8 pigs. The 24 remaining pigs had diffuse cystic endometrial hyperplasia, of which 14 had smooth muscle tumors, including leiomyomas and leiomyosarcomas, in the uterus or broad ligament. Nodular endometrial lesions—including adenocarcinomas, adenomas, and/or adenomyosis—were present in 10 pigs, 3 of which had concurrent smooth muscle tumors. Pyometra was present in 3 pigs. In uterine sections with cystic endometrial hyperplasia, adenomyosis, or adenomas, approximately 70% of epithelial nuclei expressed estrogen receptor and progesterone receptor immunohistochemically; in adenocarcinomas, expression was 20 ...


Lycoperdonosis In Two Dogs, T Alenghat, Carla Pillitteri, David Bemis, L Kellett-Gregory, K Jackson, Stephen Kania, Robert Donnell, T Van Winkle Aug 2012

Lycoperdonosis In Two Dogs, T Alenghat, Carla Pillitteri, David Bemis, L Kellett-Gregory, K Jackson, Stephen Kania, Robert Donnell, T Van Winkle

Stephen A Kania

Lycoperdonosis is a rare respiratory disease that results from the inhalation of spores released from the Lycoperdon (puffball) mushroom. In the present study, 2 cases of confirmed canine lycoperdonosis are described. The first case presented to the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, and the second case was submitted for postmortem examination to the University of Tennessee Veterinary Teaching Hospital. Both dogs presented in respiratory distress, and owners reported that the dogs had been playing or digging in areas with puffball mushrooms prior to the onset of clinical signs. In the initial case, thoracic radiographs revealed ...


Thyroid Neoplasia In Captive Raccoons (Procyon Lotor), Stephanie Mccain, Matthew Allender, Mark Bohling, Edward Ramsay, Federica Morandi, Kim Newkirk Aug 2012

Thyroid Neoplasia In Captive Raccoons (Procyon Lotor), Stephanie Mccain, Matthew Allender, Mark Bohling, Edward Ramsay, Federica Morandi, Kim Newkirk

Kim M Newkirk

Two adult, spayed, female raccoons were diagnosed with thyroid neoplasia. One raccoon had a palpable, left-sided, nonfunctional thyroid adenocarcinoma which was treated with a thyroidectomy twice with local recurrence both times. After the second recurrence, pulmonary metastases were identified. A third thyroidectomy was performed, and a vascular access port was placed for administration of intravenous doxorubicin. The raccoon developed pancytopenia and became anorexic after chemotherapy, and the owner elected humane euthanasia. The second raccoon had nonpalpable, bilateral, functional follicular thyroid adenomatous hyperplasia and was treated with a right thyroidectomy and a partial left thyroidectomy, leaving behind the grossly normal portion ...


Comparison Of Chemistry Analytes Between 2 Portable, Commercially Available Analyzers And A Conventional Laboratory Analyzer In Reptiles, S Mccain, Bente Flatland, Juergen Schumacher, E Clarke, Michael Fry Jul 2012

Comparison Of Chemistry Analytes Between 2 Portable, Commercially Available Analyzers And A Conventional Laboratory Analyzer In Reptiles, S Mccain, Bente Flatland, Juergen Schumacher, E Clarke, Michael Fry

Juergen P. Schumacher

Background: Advantages of handheld and small bench-top biochemical analyzers include requirements for smaller sample volume and practicality for use in the field or in practices, but little has been published on the performance of these instruments compared with standard reference methods in analysis of reptilian blood. Objective: The aim of this study was to compare reptilian blood biochemical values obtained using the Abaxis VetScan Classic bench-top analyzer and a Heska i-STAT handheld analyzer with values obtained using a Roche Hitachi 911 chemical analyzer. Methods: Reptiles, including 14 bearded dragons (Pogona vitticeps), 4 blue-tongued skinks (Tiliqua gigas), 8 Burmese star tortoises ...


Early Detection, Aggressive Therapy: Optimizing The Management Of Feline Mammary Masses, Fernanda Gimenez, Silke Hecht, Linden Craig, Alfred Legendre Jul 2012

Early Detection, Aggressive Therapy: Optimizing The Management Of Feline Mammary Masses, Fernanda Gimenez, Silke Hecht, Linden Craig, Alfred Legendre

Alfred M Legendre DVM, MS, DACVIM

No abstract provided.


Improving Curriculum Delivery By Improving Faculty Teaching: A Program For Faculty Development And Dialogue, India Lane, Michael Sims, Nancy Howell, M. Bailey, James Brace Apr 2012

Improving Curriculum Delivery By Improving Faculty Teaching: A Program For Faculty Development And Dialogue, India Lane, Michael Sims, Nancy Howell, M. Bailey, James Brace

India F. Lane

No abstract provided.


Improving Curriculum Delivery By Improving Faculty Teaching: A Program For Faculty Development And Dialogue, India Lane, Michael Sims, Nancy Howell, M. Bailey, James Brace Mar 2012

Improving Curriculum Delivery By Improving Faculty Teaching: A Program For Faculty Development And Dialogue, India Lane, Michael Sims, Nancy Howell, M. Bailey, James Brace

Michael H. Sims

No abstract provided.


Ultrasonographic Observation Of Secretin-Induced Pancreatic Duct Dilation In Healthy Cats, Matthew Baron, Silke Hecht, Andrea Matthews, Jennifer Stokes Mar 2012

Ultrasonographic Observation Of Secretin-Induced Pancreatic Duct Dilation In Healthy Cats, Matthew Baron, Silke Hecht, Andrea Matthews, Jennifer Stokes

Jennifer E. Stokes DVM, DACVIM, College of Veterinary Medicine

Secretin is a polypeptide hormone that stimulates secretion of bicarbonate from the exocrine pancreas and, in healthy human subjects, causes transient pancreatic duct dilation observable sonographically. In humans with chronic pancreatitis, secretin administration fails to cause pancreatic duct dilation, theoretically due to the restrictive effects of periductal fibrosis. We characterized the effect of exogenous secretin administration on the width of the pancreatic duct in nine healthy domestic cats. Cats were given a commercially available secretin product (ChiRho Stim) while the pancreatic duct was monitored sonographically. Mean pancreatic duct diameter increased from 0.77 +/- 0.33 to 1.42 +/- 0.40 ...


Adiponectin Mrna Expression In The Cat (Felis Domesticus), Stephen Kania, Angela Lusby, Joe Bartges, Claudia Kirk Mar 2012

Adiponectin Mrna Expression In The Cat (Felis Domesticus), Stephen Kania, Angela Lusby, Joe Bartges, Claudia Kirk

Stephen A Kania

Problem statement: Adiponectin is a hormone expressed from adipose tissue in people, rodents and dogs. Adiponectin has anti-inflammatory action with beneficial effects on cardiovascular health and insulin sensitivity. With increasing fat mass, adiponectin concentrations paradoxically decrease. Adiponectin’s role in metabolism and diabetes mellitus is of interest in feline medicine because cats are susceptible to developing type II diabetes with weight gain. This study determined relative amounts of adiponectin mRNA expression from various body tissues and organs in domestic cats. Approach: Two intact male cats and one intact female cat were evaluated post-mortem. All cats were estimated to be young ...


Sensitivity And Specificity Of A Nested Polymerase Chain Reaction For Detection Of Lentivirus Infection In Lions (Panthera Leo), H Adams, M Van Vuuren, Stephen Kania, A Bosman, D Keet, J New, Melissa Kennedy Mar 2012

Sensitivity And Specificity Of A Nested Polymerase Chain Reaction For Detection Of Lentivirus Infection In Lions (Panthera Leo), H Adams, M Van Vuuren, Stephen Kania, A Bosman, D Keet, J New, Melissa Kennedy

Stephen A Kania

Feline immunodeficiency virus (FIV) is a lentivirus in the Retroviridae family that causes lifelong infection in domestic cats. The lentivirus of African lions (Panthera leo), referred to as FIVple, is endemic in certain lion populations in eastern and southern Africa. Lentivirus infection leads to immunologic dysfunction and immunosuppressive disease in domestic cats; however, little is known about the pathogenic effects of infection in lions, nor about the epidemiologic impact on free-ranging and captive populations. Whole blood and serum samples were collected opportunistically from free-ranging lions in Kruger National Park, Republic of South Africa (RSA). Whole blood and serum samples were ...


Diagnosis Of Aeromonas Hydrophila, Mycobacterium Species, And Batrachochytrium Dendrobatidis In An African Clawed Frog (Xenopus Laevis)., William Hill, Shelley Newman, Linden Craig, Chris Carter, Jane Czarra, Julie Brown Feb 2012

Diagnosis Of Aeromonas Hydrophila, Mycobacterium Species, And Batrachochytrium Dendrobatidis In An African Clawed Frog (Xenopus Laevis)., William Hill, Shelley Newman, Linden Craig, Chris Carter, Jane Czarra, Julie Brown

Linden E. Craig DVM, Ph.D., DACVP, College of Veterinary Medicine

Here we describe diagnosis of concurrent infection with Aeromonas hydrophila, Mycobacterium spp., and Batrachochytrium dendrobatidis in a wild female Xenopus laevis captured in Chile and transported to the United States. After approximately 130 d in the laboratory, the frog was presented for dysecdysis and obtundation. After euthanasia, tissues were submitted for histopathologic evaluation and PCR analysis for B. dendrobatidis and Ranavirus. Clinically significant gross lesions included cutaneous ulcerations on the lip, right forelimb, and ventral chest. Microscopic findings included regionally extensive splenic necrosis, diffuse pneumonia, and fibrinous coelomitis all containing intralesional bacteria. PCR analysis yielded positive results for B. dendrobatidis ...