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2004

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Articles 1 - 30 of 1957

Full-Text Articles in Medicine and Health Sciences

Potentiated Caspase-3 In Ras-Transformed 10t1/2 Cells, P Song, J Wei, Howard Plummer, Hwa-Chain Wang Dec 2015

Potentiated Caspase-3 In Ras-Transformed 10t1/2 Cells, P Song, J Wei, Howard Plummer, Hwa-Chain Wang

Howard K. Plummer III

Procaspase-3 protein content is highly elevated in fully Ras-transformed mouse embryo fibroblast 10T1/2 cells in which ectopic expression of oncogenic H-Ras is induced by a tetracycline-regulated expression system. Blockage of the ERK pathway results in profound reduction of transcript and protein content of procaspase-3 in both Ras-transformed and non-transformed counterpart 10T1/2 cells, indicating that the ERK pathway is involved in procaspase-3 gene expression. The elevated procaspase-3 protein content appears to facilitate the proteolytic production of active caspase-3 during selective induction of apoptosis of Ras-transformed cells by a discriminating anticancer agent, FR901228, whereas it induces growth arrest of non-transformed ...


Diagnosis Of Congenital Cardiac Right-To-Left Shunts With 99mtc-Macroaggregated Albumin, Federica Morandi, Gregory Daniel, Rebecca Gompf, A Bahr Jul 2013

Diagnosis Of Congenital Cardiac Right-To-Left Shunts With 99mtc-Macroaggregated Albumin, Federica Morandi, Gregory Daniel, Rebecca Gompf, A Bahr

Federica Morandi

Diagnosing right-to-left congenital cardiac shunts can be difficult. Cardiac catheterization and angiocardiography represent the traditional gold standard for diagnosis, but they are invasive. Nuclear scintigraphy using 99mTc-macroaggregated albumin (MAA) has been employed in humans as an alternate method of diagnosis. This study reviews eight dogs presented for evaluation of a suspect right-to-left cardiac shunt that were examined using 99mTc-MAA. In all, 2-4 mCi (74-148 MBq) of reduced particle 99mTc-MAA were injected IV in a cephalic vein and static images of the whole body, including right and left lateral, dorsal, and ventral views, were acquired for 60 s and stored into ...


Angiotensin Ii–Induced Protein Kinase D Activation Is Regulated By Protein Kinase C{Delta} And Mediated Via The Angiotensin Ii Type 1 Receptor In Vascular Smooth Muscle Cells, Mingqi Tan, Xuemin Xu, Motoi Ohba, Mei-Zhen Cui Jun 2013

Angiotensin Ii–Induced Protein Kinase D Activation Is Regulated By Protein Kinase C{Delta} And Mediated Via The Angiotensin Ii Type 1 Receptor In Vascular Smooth Muscle Cells, Mingqi Tan, Xuemin Xu, Motoi Ohba, Mei-Zhen Cui

Mei-Zhen Cui

Objective— Angiotensin II (Ang II), through its specific signaling cascades, exerts multiple effects on vascular smooth muscle cells (SMCs). It has been shown that Ang II stimulates activation of protein kinase D (PKD), a member of a new class of serine–threonine kinases. However, little is known regarding the upstream cascade of the intracellular signaling that leads to PKD activation. In the present study, we investigated upstream molecules that mediate Ang II–induced PKD activation in SMCs. Methods and Results— Protein kinase C (PKC) inhibitors completely block Ang II–induced PKD activation, and pretreatment with phorbol 12,13-dibutyrate downregulates Ang ...


Identification Of A New Presenilin-Dependent Zeta-Cleavage Site Within The Transmembrane Domain Of Amyloid Precursor Protein, G Zhao, G Mao, J Tan, Y Dong, Mei-Zhen Cui, Sh Kim, Xuemin Xu Jun 2013

Identification Of A New Presenilin-Dependent Zeta-Cleavage Site Within The Transmembrane Domain Of Amyloid Precursor Protein, G Zhao, G Mao, J Tan, Y Dong, Mei-Zhen Cui, Sh Kim, Xuemin Xu

Mei-Zhen Cui

Gamma-secretase cleavage of beta-amyloid precursor protein (APP) is crucial in the pathogenesis of Alzheimer disease, because it is the decisive step in the formation of the C terminus of beta-amyloid protein (Abeta). To better understand the molecular events involved in gamma-secretase cleavage of APP, in this study we report the identification of a new intracellular long Abeta species containing residues 1-46 (Abeta46), which led to the identification of a novel zeta-cleavage site between the known gamma- and epsilon-cleavage sites within the transmembrane domain of APP. Our data clearly demonstrate that the new zeta-cleavage is a presenilin-dependent event. It is also ...


A New Dissection Technique For Approach To Right-Sided Intrahepatic Portosystemic Shunts: Anatomic Study And Use In Three Dogs, Karen Tobias, Jm Byarlay, Robert Henry Mar 2013

A New Dissection Technique For Approach To Right-Sided Intrahepatic Portosystemic Shunts: Anatomic Study And Use In Three Dogs, Karen Tobias, Jm Byarlay, Robert Henry

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Objective— To determine the feasibility of indirect suture passage around the right portal vein for attenuation of right-sided intrahepatic portosystemic shunts (IHPSS). Study Design— Anatomic study of cadavers and prospective evaluation of clinical cases. Animals— Nine canine cadavers (median weight, 20.5 kg) and 6 client-owned dogs suspected of having right-sided IHPSS. Methods— Silicone casts of the caudal vena cava and pre- and intrahepatic portal veins were made in fresh canine cadavers. A suture was passed dorsal to the portal vein above and below its bifurcation and pulled laterally so that it surrounded the right portal vein. The number and ...


Mental Health And Employment Transitions, Carole Gresenz, Roland Sturm Jan 2013

Mental Health And Employment Transitions, Carole Gresenz, Roland Sturm

Roland Sturm

No abstract provided.


Does Relative Deprivation Predict The Need For Mental Health Services?, Christine Eibner, Carole Gresenz, Roland Sturm Jan 2013

Does Relative Deprivation Predict The Need For Mental Health Services?, Christine Eibner, Carole Gresenz, Roland Sturm

Roland Sturm

No abstract provided.


Methicillin Resistance Of Staphylococci Isolated From The Skin Of Dogs With Pyoderma, Stephen Kania, Nicola Williamson, Linda Frank, Rebecca Wilkes, Rebekah Jones, David Bemis Oct 2012

Methicillin Resistance Of Staphylococci Isolated From The Skin Of Dogs With Pyoderma, Stephen Kania, Nicola Williamson, Linda Frank, Rebecca Wilkes, Rebekah Jones, David Bemis

Rebecca P. Wilkes DVM, PhD, DACVM

Objective—To determine the methicillin-resistant profile of staphylococcal isolates from the skin of dogs with pyoderma. Animals—90 dogs with pyoderma. Procedure—Staphylococci isolated from dogs with pyoderma were tested for susceptibility to methicillin by use of a standard disk diffusion test with oxacillin disks. The DNA extracted from the isolates was tested for the mecA gene that encodes the penicillinbinding protein 2a (PBP2a) by use of a polymerase chain reaction (PCR) assay. The expression of PBP2a was determined with a commercial latex agglutination assay. Species of staphylococcal isolates were identified by use of morphologic, biochemical, and enzymatic tests. Results ...


Correlation Of Computed Tomographic Images With Anatomic Features Of The Abdomen Of Ringed Seals (Phoca Hispida), H Smodlaka, Robert Henry, Gb Daniel, Robert Reed Jul 2012

Correlation Of Computed Tomographic Images With Anatomic Features Of The Abdomen Of Ringed Seals (Phoca Hispida), H Smodlaka, Robert Henry, Gb Daniel, Robert Reed

Robert B. Reed, Jr., DVM, Ph.D.

OBJECTIVE: To correlate anatomic features of the abdomen of the ringed seal (Phoca hispida) identified in plastinated cross-sections with images obtained via computed tomography (CT) and thereby establish reference standards for normal abdominal organ size and position in this species. SAMPLE POPULATION: 2 adult male ringed seal cadavers. PROCEDURE: With the seal in sternal recumbency, CT images of the abdomen were acquired by use of a 4th-generation CT scanner. Image slice thickness was 1 cm, with no interslice gap. After imaging, the abdominal region was sectioned transversely into 4-cm slices, which were plastinated and photographed. Plastinated slices were matched to ...


Effects Of A Mock Ultrasonographic Procedure On Cortisol Concentrations During Low-Dose Dexamethasone Suppression Testing In Clinically Normal Adult Dogs, Elizabeth May, Linda Frank, Keith Hnilica, India Lane Apr 2012

Effects Of A Mock Ultrasonographic Procedure On Cortisol Concentrations During Low-Dose Dexamethasone Suppression Testing In Clinically Normal Adult Dogs, Elizabeth May, Linda Frank, Keith Hnilica, India Lane

India F. Lane

Objective—To determine whether the stress of an ultrasonographic procedure would interfere with the suppressive effect of dexamethasone during a lowdose dexamethasone suppression test (LDDST) in healthy dogs. Animals—6 clinically normal adult dogs. Procedure—In phase 1, an LDDST was performed 5 times at weekly intervals in each dog. Serum samples were obtained 0, 2, 4, 6, and 8 hours after dexamethasone injection. A mock 20-minute abdominal ultrasonographic examination was performed on all dogs at each time point during the LDDST on weeks 2 through 5. In phase 2, serum cortisol concentrations were measured before and immediately after a ...


Thoracic And Pelvic Limb Fracture And Luxation Management In Raptors, Marcy Souza, Erica Fields, L Degernes Feb 2012

Thoracic And Pelvic Limb Fracture And Luxation Management In Raptors, Marcy Souza, Erica Fields, L Degernes

Erica L. Fields DVM, DACVR College of Veterinary Medicine

No abstract provided.


Results Of Arthroscopic Versus Open Arthrotomy For Surgical Management Of Cranial Cruciate Ligament Deficiency In Dogs, Michael Hoelzler, Darryl Millis, David Francis, Joseph Weigel Feb 2012

Results Of Arthroscopic Versus Open Arthrotomy For Surgical Management Of Cranial Cruciate Ligament Deficiency In Dogs, Michael Hoelzler, Darryl Millis, David Francis, Joseph Weigel

Darryl L. Millis

Objective— To evaluate postoperative morbidity in dogs after experimental cranial cruciate ligament transection and immediate stifle stabilization using an arthroscopically assisted or open arthrotomy technique. Study Design— Experimental, prospective study. Animals— Thirteen mature, healthy dogs. Methods— Dogs were randomly assigned to 1 of 2 groups. Seven underwent open arthrotomy while 6 underwent arthroscopy of 1 stifle joint. Cranial cruciate ligaments were transected and debrided and all stifles were stabilized using 2 lateral extracapsular fabellar-tibial sutures. Minimally invasive suture placement was employed in the arthroscopy group. All animals were evaluated for 9 weeks using kinetic gait assessments, comfortable stifle range of ...


Physiologic Responses Of Amazon Parrots (Amazona Species) To Manual Restraint, Cheryl Greenacre, Angela Lusby Feb 2012

Physiologic Responses Of Amazon Parrots (Amazona Species) To Manual Restraint, Cheryl Greenacre, Angela Lusby

Cheryl B Greenacre DVM

Body temperature and heart and respiratory rates are measured routinely during the physical examination of most animals. However, the influence of stress on these values has not been well evaluated in birds. In this study, we measured the cloacal temperature and heart and respiratory rates serially during 15 minutes of restraint in 17 Amazon parrots (Amazona species). The mean cloaca temperature of the parrots increased significantly (P <.001) within 4 minutes of manual restraint and increased by 2.3degreesC (4.2degreesF) at 15 minutes. Mean respiratory rates also increased significantly (P <.001) from 129 to 252 breaths/min during 15 minutes of manual restraint, while mean heart rates did not significantly change. These findings emphasize the importance of limiting restraint time and observing for tachypnea, even in healthy parrots, to avoid potentially life-threatening increases in body temperature.


Effect Of Intranasal Vaccination Against Bovine Enteric Coronavirus On The Occurrence Of Respiratory Tract Disease In A Commercial Backgrounding Feedlot, Paul Plummer, Barton Rohrbach, R Daugherty, K Thomas, R Wilkes, F Duggan, Melissa Kennedy Jan 2012

Effect Of Intranasal Vaccination Against Bovine Enteric Coronavirus On The Occurrence Of Respiratory Tract Disease In A Commercial Backgrounding Feedlot, Paul Plummer, Barton Rohrbach, R Daugherty, K Thomas, R Wilkes, F Duggan, Melissa Kennedy

Melissa A. Kennedy

Objective - To measure antibody titers against bovine coronavirus (BCV), determine frequency of BCV in nasal swab specimens, and compare calves treated for bovine respiratory tract disease (BRD) between those given an intranasally administered vaccine and control calves. Design - Randomized clinical trial. Animals - 414 heifer calves. Procedure - Intranasal BCV antigen concentration and antibody titre against BCV were measured on entry to a feedlot. Calves were randomly assigned to receive 3.0 mL of a modified-live virus vaccine against bovine enteric coronavirus and rotavirus or 3.0 mL of saline (0.9% NaCl) solution. Calves were confined to 1 of 2 pens ...


Calculating A Patient's Nutritional Requirements, Joe Bartges, Claudia Kirk, Susan Lauten Dec 2011

Calculating A Patient's Nutritional Requirements, Joe Bartges, Claudia Kirk, Susan Lauten

Claudia A Kirk

No abstract provided.


Effects Of Diet On Urine Composition Of Cats With Calcium Oxalate Urolithiasis, J Lulich, C Osborne, C Lekcharoensuk, Claudia Kirk, Joe Bartges Dec 2011

Effects Of Diet On Urine Composition Of Cats With Calcium Oxalate Urolithiasis, J Lulich, C Osborne, C Lekcharoensuk, Claudia Kirk, Joe Bartges

Claudia A Kirk

Ten client-owned cats with calcium oxalate (CaOx) urolithiasis were evaluated to determine the effect of diet on urine CaOx saturation. Two dietary treatments were evaluated in each cat: the diet consumed just prior to urolith detection and a canned diet formulated to prevent CaOx uroliths. This study revealed that hypercalciuria is a consistent abnormality in cats with CaOx urolith formation. When urolith-forming cats consumed a diet formulated to prevent urolith formation, activity product ratios for CaOx (which estimate the degree to which urine is saturated with CaOx) were significantly lower. These results suggest that consumption of an appropriately formulated urolith-prevention ...


Informatics In Health Care, David Scott, Bruce Levin, Ardis Hanson Oct 2011

Informatics In Health Care, David Scott, Bruce Levin, Ardis Hanson

Bruce Lubostsky Levin, DrPH, MPH

Introduction to Health Care Delivery: A Primer for Pharmacists, Third Edition, offers a current and comprehensive picture of the U.S. health care delivery system while emphasizing the perspective of the pharmacy profession. Each chapter in the new edition of this practical text begins with a real-world case study that demonstrates the connection between the concepts reviewed and the pharmacist's role.


An Overview Of Issues In Prevention, Integration With Primary Care, And Parity, Bruce Levin, Ardis Hanson, Kevin Hennessey Oct 2011

An Overview Of Issues In Prevention, Integration With Primary Care, And Parity, Bruce Levin, Ardis Hanson, Kevin Hennessey

Bruce Lubostsky Levin, DrPH, MPH

No abstract provided.


Diagnostic Value Of A Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test In Equine Cushing's Disease, Frank Andrews, Nicholas Frank, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Malcolm Mccracken Aug 2011

Diagnostic Value Of A Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test In Equine Cushing's Disease, Frank Andrews, Nicholas Frank, Carla Sommardahl, Hugo Eiler, Barton Rohrbach, Malcolm Mccracken

Carla S. Sommardahl

A combined dexamethasone suppression/thyrotropin releasing hormone (DEX/TRH) test is being used in the early diagnosis of Equine Cushing's disease (ECD), but the accuracy of this test has not been established. In this study, horses were tested using the DEX/TRH test, and the results were compared with the "gold standard" of histopathologic examination of the pituitary gland. Sensitivity and specificity of the test were 88% and 79%, respectively. Predictive values of positive and negative tests in our study population were 81% and 87%, respectively. When the test was applied to horses 11 yr old, the DEX/TRH ...


Mice Heterozygous For Atp10c, A Putative Amphipath, Represent A Novel Model Of Obesity And Type 2 Diabetes, Madhu Dhar, Carla Sommardahl, Tanisa Kirkland, Sarah Nelson, Robert Donnell, Dabney Johnson, Lawrence Castellani Aug 2011

Mice Heterozygous For Atp10c, A Putative Amphipath, Represent A Novel Model Of Obesity And Type 2 Diabetes, Madhu Dhar, Carla Sommardahl, Tanisa Kirkland, Sarah Nelson, Robert Donnell, Dabney Johnson, Lawrence Castellani

Carla S. Sommardahl

Atp10c is a novel type IV P-type ATPase and is a putative phospholipid transporter. The purpose of this study was to assess the overall effect of the heterozygous deletion of Atp10c on obesity-related phenotypes and metabolic abnormalities in mice fed a high-fat diet. Heterozygous mice with maternal inheritance of Atp10c were compared with heterozygous mice with paternal inheritance of Atp10c and wild-type controls. Body weight, adiposity index, and plasma insulin, leptin and triglyceride concentrations were significantly greater in the mutants inheriting the deletion maternally compared with their sex- and age-matched control male mice fed a 10% fat (% energy) diet and ...


Effect Of Morphine And Flunixin Meglumine On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, W Will, Barton Rohrbach, Dennis Geiser Aug 2011

Effect Of Morphine And Flunixin Meglumine On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, W Will, Barton Rohrbach, Dennis Geiser

Thomas J Doherty

Objective: To determine the effect of morphine and flunixin meglumine on isoflurane (ISO) minimum alveolar concentration (MAC) in goats. Study design: Prospective, randomized experimental study. Animals: Five adult, wether goats from 1 to 3 years in age, and weighing 24-65 kg. Methods: Anesthesia was induced using ISO, which was delivered via a mask. Goats were intubated and ventilated to maintain an end-tidal carbon dioxide concentration between 25 and 30 mm Hg (3.3-4 kPa). End-tidal ISO concentration was measured using an infrared analyzer. The baseline ISO MAC that prevented purposeful movement in response to clamping a claw was determined. Following ...


Effects Of Various Anesthetic Agents On Laryngeal Motion During Laryngoscopy In Normal Dogs, Aaron Jackson, Karen Tobias, Cassie Long, Joseph Bartges, Ralph Harvey Jun 2011

Effects Of Various Anesthetic Agents On Laryngeal Motion During Laryngoscopy In Normal Dogs, Aaron Jackson, Karen Tobias, Cassie Long, Joseph Bartges, Ralph Harvey

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Objective— To evaluate the effects of various drugs and drug combinations conventionally used for anesthesia on arytenoid cartilage motion during laryngoscopy in normal dogs. Study Design— Experimental study. Animals— Six large breed healthy dogs with no previous history of respiratory dysfunction. Methods— Each dog was randomly assigned to a different injectable anesthetic protocol once weekly for 6 weeks, then in the 7th week all dogs were anesthetized with isoflurane. Videolaryngoscopy was performed and recorded starting immediately after induction until dogs could no longer be safely restrained for endoscopy. Video was digitized and 3 still images ofmaximalinspiration and expiration from the ...


In Vitro Efficacy Of A Polyhexamethylene Biguanide-Impregnated Gauze Dressing Against Bacteria Found In Veterinary Patients, W Lee, Karen Tobias, David Bemis, Barton Rohrbach Jun 2011

In Vitro Efficacy Of A Polyhexamethylene Biguanide-Impregnated Gauze Dressing Against Bacteria Found In Veterinary Patients, W Lee, Karen Tobias, David Bemis, Barton Rohrbach

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Objective - To evaluate the in vitro efficacy of polyhexamethylene biguanide (PHMB)-impregnated gauze dressing in limiting the growth of bacteria both within and underneath the dressing. Study Design - In vitro study. Methods - Squares of PHMB-impregnated and control gauze were placed on agar plates inoculated with 1 of 11 bacterial species, including 8 multi-resistant organisms. Growth under the gauze was assessed qualitatively after 24-hour incubation. Repeated use of sponges was used to evaluate residual inhibitory activity against Micrococcus lutea and Staphylococcus schleiferi ss. schleiferi. In a second procedure, PHMB-impregnated and control gauze squares were placed in sterile plastic wells and inoculated ...


Electroretinography In The Hispaniolan Amazon Parrot (Amazona Ventralis), Diane Hendrix, Michael Sims Jun 2011

Electroretinography In The Hispaniolan Amazon Parrot (Amazona Ventralis), Diane Hendrix, Michael Sims

Michael H. Sims

Electroretinography is a noninvasive method of evaluating retinal function, which is especially useful when evaluating patients with cataracts. This study was undertaken to characterize the normal latencies, amplitudes, and presence of oscillatory potentials in the electroretinogram of Hispaniolan Amazon parrots (Amazona ventralis). Six healthy 3-year-old parrots with clinically normal eyes were anesthetized with isoflurane. Electroretinograms were recorded in the light- and dark-adapted states with white light and in the dark-adapted state with white, red, and blue light. Oscillatory potentials were also recorded. The mean latency for the light-adapted a-wave was 11.35 (±1.54) milliseconds and for the light-adapted b-wave ...


Effect Of Morphine And Flunixin Meglumine On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, W Will, Barton Rohrbach, Dennis Geiser Oct 2010

Effect Of Morphine And Flunixin Meglumine On Isoflurane Minimum Alveolar Concentration In Goats, Thomas Doherty, W Will, Barton Rohrbach, Dennis Geiser

Dennis R. Geiser DVM, DAVBP

Objective: To determine the effect of morphine and flunixin meglumine on isoflurane (ISO) minimum alveolar concentration (MAC) in goats. Study design: Prospective, randomized experimental study. Animals: Five adult, wether goats from 1 to 3 years in age, and weighing 24-65 kg. Methods: Anesthesia was induced using ISO, which was delivered via a mask. Goats were intubated and ventilated to maintain an end-tidal carbon dioxide concentration between 25 and 30 mm Hg (3.3-4 kPa). End-tidal ISO concentration was measured using an infrared analyzer. The baseline ISO MAC that prevented purposeful movement in response to clamping a claw was determined. Following ...


Comparison Of Histologic Lesions Of Endophthalmitis Induced By Blastomyces Dermatitidis In Untreated And Treated Dogs: 36 Cases (1986-2001), Diane Hendrix, Barton Rohrbach, P Bochsler, R English Sep 2010

Comparison Of Histologic Lesions Of Endophthalmitis Induced By Blastomyces Dermatitidis In Untreated And Treated Dogs: 36 Cases (1986-2001), Diane Hendrix, Barton Rohrbach, P Bochsler, R English

Diane Hendrix

Objective - To compare prevalence of organisms and histologic changes in eyes from dogs with blastomycosis that were either untreated or undergoing treatment with itraconazole. Design - Retrospective study. Animals - 36 dogs with endophthalmitis associated with blastomycosis. Procedure - Signalment, results of ophthalmic examination, and duration of treatment with itraconazole were extracted from medical records. Histologic sections from eyes were examined for prevalence and viability (ie, budding) of fungal organisms. A scoring system was devised to assess the degree of inflammation. Results - Clinically, all eyes were blind and had signs of severe endophthalmitis. Histologically, the type and degree of inflammation and prevalence of ...


Development Of Dose Conversion Coefficients For Radionuclides Produced In Spallation Neutron Sources: Quarterly Progress Report 9/1/04 – 12/31/04, Phillip W. Patton, Mark Rudin Dec 2004

Development Of Dose Conversion Coefficients For Radionuclides Produced In Spallation Neutron Sources: Quarterly Progress Report 9/1/04 – 12/31/04, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

The research consortium comprised of representatives from several universities and national laboratories has successfully generated internal and external dose conversion coefficients for twenty radionuclides produced in spallation neutron sources. In addition, the group has identified twenty radionuclide that are missing electron capture files and eighteen additional radionuclides missing substantial physical data.


Modulating Hiv-1 Replication By Rna Interference Directed Against Human Transcription Elongation Factor Spt5, Yueh-Hsin Ping, Chia-Ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, Tariq M. Rana Dec 2004

Modulating Hiv-1 Replication By Rna Interference Directed Against Human Transcription Elongation Factor Spt5, Yueh-Hsin Ping, Chia-Ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, Tariq M. Rana

Open Access Articles

BACKGROUND: Several cellular positive and negative elongation factors are involved in regulating RNA polymerase II processivity during transcription elongation in human cells. In recruiting several of these regulatory factors to the 5' long terminal repeat (LTR) promoter during transcription elongation, HIV-1 modulates replication of its genome in a process mediated by the virus-encoded transactivator Tat. One particular cellular regulatory factor, DSIF subunit human SPT5 (hSpt5), has been implicated in both positively and negatively regulating transcriptional elongation but its role in Tat transactivation in vivo and in HIV-1 replication has not been completely elucidated. RESULTS: To understand the in vivo function ...


Regulation Of Cell Cycle By The Anaphase Spindle Midzone, Maki Murata-Hori, Greenfield Sluder, Yu-Li Wang Dec 2004

Regulation Of Cell Cycle By The Anaphase Spindle Midzone, Maki Murata-Hori, Greenfield Sluder, Yu-Li Wang

Open Access Articles

BACKGROUND: A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting that the spindle midzone and/or midbody may play a role in regulating the following cell cycle.

RESULTS: We microsurgically severed NRK epithelial cells during anaphase or telophase, such that the spindle midzone/midbody was associated with only one of the daughter cells. Time-lapse recording of cells severed during early anaphase indicated that the cell with midzone underwent cytokinesis-like cortical contractions and progressed normally through the interphase, whereas the cell ...


Isolating Adult Psychological Correlates Of Witnessing Parental Violence: Findings From A Predominantly Latina Sample, Corrie A. Davies, David Dilillo, Isaac G. Martinez Dec 2004

Isolating Adult Psychological Correlates Of Witnessing Parental Violence: Findings From A Predominantly Latina Sample, Corrie A. Davies, David Dilillo, Isaac G. Martinez

Faculty Publications, Department of Psychology

This study examined the relationship between childhood exposure to parental violence and adult psychological functioning in a sample of predominantly Mexican American participants. Questionnaires assessing childhood maltreatment, family environment, and current psychological symptomatology were completed by 142 female undergraduates. Findings revealed that witnessing parental violence in childhood was associated with depressive symptoms, low self-esteem, and trauma symptoms in adulthood, even after controlling for child physical and sexual abuse. However, in subsequent analyses, also controlling for levels of nonphysical family conflict, previous associations between exposure to parental violence and adult symptomatology were reduced, such that trauma-related symptoms remained the sole outcome ...