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Articles 1 - 30 of 3982

Full-Text Articles in Medicine and Health Sciences

A Case-Control Study Of Sporadic Canine Blastomycosis In Tennessee, Usa., Thomas Chen, Alfred Legendre, Chris Bass, Shannon Mays, Agricola Odoi Apr 2015

A Case-Control Study Of Sporadic Canine Blastomycosis In Tennessee, Usa., Thomas Chen, Alfred Legendre, Chris Bass, Shannon Mays, Agricola Odoi

Thomas Chen DVM, DACVO

This study investigated environmental and host risk factors of canine blastomycosis in Knox County, Tennessee, USA. Data on 78 cases and 146 randomly selected controls were extracted from the medical database at the University of Tennessee Veterinary Teaching Hospital for the period 1977-1999. Home addresses of cases and controls were geocoded and linked to environmental risk factor data using a Geographic Information System (GIS) software. Multiple logistic regression analysis was performed to identify environmental and host factors associated with risk of canine blastomycosis. Important risk factors in the study area were sex, breed, age, and proximity to water whereas, soil ...


Induction And Recovery Characteristics And Cardiopulmonary Effects Of Sevoflurane And Isoflurane In Bald Eagles, Priscilla Joyner, Michael Jones, Daniel Ward, Rebecca Gompf, Nancy Zagaya, Jonathan Sleeman Dec 2013

Induction And Recovery Characteristics And Cardiopulmonary Effects Of Sevoflurane And Isoflurane In Bald Eagles, Priscilla Joyner, Michael Jones, Daniel Ward, Rebecca Gompf, Nancy Zagaya, Jonathan Sleeman

Daniel A. Ward

Objective—To compare induction and recovery characteristics and cardiopulmonary effects of isoflurane and sevoflurane in bald eagles.

Animals—17 healthy adult bald eagles.

Procedures—Anesthesia was induced with isoflurane or sevoflurane delivered in oxygen via a facemask in a crossover design with 4 weeks between treatments. Eagles were intubated, allowed to breathe spontaneously, and instrumented for cardiopulmonary measurements. Time to induction, extubation, and recovery, as well as smoothness of recovery, were recorded.

Results—Administration of sevoflurane resulted in a significantly quicker recovery, compared with isoflurane. Temperature, heart rate, and respiratory rate significantly decreased over time, whereas systolic (SAP), diastolic (DAP ...


Histamine Induces Egr-1 Expression In Human Aortic Endothelial Cells Via The H1 Receptor-Mediated Protein Kinase Cdelta-Dependent Erk Activation Pathway, F Hao, M Tan, Xuemin Xu, Mei-Zhen Cui Jun 2013

Histamine Induces Egr-1 Expression In Human Aortic Endothelial Cells Via The H1 Receptor-Mediated Protein Kinase Cdelta-Dependent Erk Activation Pathway, F Hao, M Tan, Xuemin Xu, Mei-Zhen Cui

Mei-Zhen Cui

Histamine, a potent inflammatory mediator, has multiple effects on the pathogenesis of atherosclerosis. This study investigates the effect of histamine on the expression of early growth response factor 1 (Egr-1), a master transcription factor that regulates the expression of an array of atherogenic genes in atherosclerotic lesions. Histamine markedly and rapidly induces Egr-1 mRNA and protein expression in primary human aortic endothelial cells (HAECs). Histamine-induced Egr-1 expression is dependent on the activation of the H1 receptor. Histamine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-regulated kinase (ERK)1/2, p38 kinase, and c-Jun N-terminal kinase (JNK) prior ...


Effects Of Gamma-Secretase Cleavage-Region Mutations On App Processing And Abeta Formation: Interpretation With Sequential Cleavage And Alpha-Helical Model, Jianxin Tan, Guozhang Mao, Mei-Zhen Cui, Shin-Chung Kang, Bruce Lamb, Boon-Seng Wong, Man-Sun Sy, Xuemin Xu Jun 2013

Effects Of Gamma-Secretase Cleavage-Region Mutations On App Processing And Abeta Formation: Interpretation With Sequential Cleavage And Alpha-Helical Model, Jianxin Tan, Guozhang Mao, Mei-Zhen Cui, Shin-Chung Kang, Bruce Lamb, Boon-Seng Wong, Man-Sun Sy, Xuemin Xu

Mei-Zhen Cui

Overwhelming evidence supports the amyloid hypothesis of Alzheimer's disease that stipulates that the relative level of the 42 amino acid beta-amyloid peptide (Abeta(42)) in relationship to Abeta(40) is critical to the pathogenesis of the disease. While it is clear that the multi-subunit gamma secretase is responsible for cleavage of the amyloid precursor protein (APP) into Abeta(42) and Abeta(40), the exact molecular mechanisms regulating the production of the various Abeta species remain elusive. To elucidate the underlying mechanisms, we replaced individual amino acid residues from positions 43 to 52 of Abeta with phenylalanine to examine the ...


Both The N-Terminal Fragment And The Protein-Protein Interaction Domain (Pdz Domain) Are Required For The Pro-Apoptotic Activity Of Presenilin-Associated Protein Psap, Guozhang Mao, Jianxin Tan, W Gao, Y Shi, Mei-Zhen Cui, Xuemin Xu Jun 2013

Both The N-Terminal Fragment And The Protein-Protein Interaction Domain (Pdz Domain) Are Required For The Pro-Apoptotic Activity Of Presenilin-Associated Protein Psap, Guozhang Mao, Jianxin Tan, W Gao, Y Shi, Mei-Zhen Cui, Xuemin Xu

Mei-Zhen Cui

Presenilin-associated protein (PSAP) was originally identified as a PS1-associated, PDZ domain protein. In a subsequent study, PSAP was found to be a mitochondrial apoptotic molecule. In this study, we cloned the PSAP gene and found that it is composed of 12 exons and localizes on chromosome 6. To better understand the structure and function of PSAP, we have generated a series of antibodies that recognize different regions of PSAP. Using these antibodies, we found that PSAP is expressed in four isoforms as a result of differential splicing of exon 8 in addition to the use of either the first or ...


Bilateral Corneoconjunctival Dermoids And Nasal Choristomas In A Calf, D Brudenall, Daniel Ward, Shelley Newman May 2013

Bilateral Corneoconjunctival Dermoids And Nasal Choristomas In A Calf, D Brudenall, Daniel Ward, Shelley Newman

Daniel A. Ward

A 5-day-old Angus x Hereford calf presented for bilateral haired masses on the eyes and nasolabial planum since birth. The masses were surgically excised from the inferonasal cornea and bulbar conjunctiva of both eyes and the left and right side of the dorsomedial nasolabial planum. Histopathology of the excised tissue confirmed bilateral corneoconjunctival dermoids with ectopic lacrimal glands, and bilateral nasal choristomas and ectopic nasal glandular tissue. Surgery was curative and healing was uneventful. Bilateral ocular dermoids in combination with nasal choristomas and ectopic glandular tissue have not been documented previously in cattle.


Allgemeine Orthopädie [General Principles Of Orthopedic Radiology], Silke Hecht, Federica Morandi, Gregory Daniel Mar 2013

Allgemeine Orthopädie [General Principles Of Orthopedic Radiology], Silke Hecht, Federica Morandi, Gregory Daniel

Silke Hecht

No abstract provided.


Frakturen [Fractures]., Federica Morandi, Silke Hecht, Gregory Daniel Mar 2013

Frakturen [Fractures]., Federica Morandi, Silke Hecht, Gregory Daniel

Silke Hecht

No abstract provided.


Wirbelsäule (Neuroradiologie Inklusive Kontrastverfahren) [Vertebral Column (Neuroradiology Including Contrast Procedures)]., Silke Hecht, Federica Morandi Mar 2013

Wirbelsäule (Neuroradiologie Inklusive Kontrastverfahren) [Vertebral Column (Neuroradiology Including Contrast Procedures)]., Silke Hecht, Federica Morandi

Silke Hecht

No abstract provided.


Knochen- Und Gelenkerkrankungen Bei Jungtieren [Bone And Joint Diseases In Young Animals]., Federica Morandi, Silke Hecht, Gregory Daniel Mar 2013

Knochen- Und Gelenkerkrankungen Bei Jungtieren [Bone And Joint Diseases In Young Animals]., Federica Morandi, Silke Hecht, Gregory Daniel

Silke Hecht

No abstract provided.


Weiterführende Bildgebende Verfahren – Ein Überblick (Ultraschall, Nuklearmedizin, Ct, Mrt) [Advanced Imaging Modalities (Ultrasound, Nuclear Medicine, Ct, Mri]., Silke Hecht, Federica Morandi Mar 2013

Weiterführende Bildgebende Verfahren – Ein Überblick (Ultraschall, Nuklearmedizin, Ct, Mrt) [Advanced Imaging Modalities (Ultrasound, Nuclear Medicine, Ct, Mri]., Silke Hecht, Federica Morandi

Silke Hecht

No abstract provided.


Erworbene Knochen- Und Gelenkerkrankungen [Acquired Bone And Joint Diseases], Federica Morandi, Silke Hecht, Gregory Daniel Mar 2013

Erworbene Knochen- Und Gelenkerkrankungen [Acquired Bone And Joint Diseases], Federica Morandi, Silke Hecht, Gregory Daniel

Silke Hecht

No abstract provided.


The Impact Of Co-Active Coaching On Physically Inactive 12 To 14 Year Olds In Ontario, Paul Gorczynski, Jennifer Irwin, Don Morrow Jan 2013

The Impact Of Co-Active Coaching On Physically Inactive 12 To 14 Year Olds In Ontario, Paul Gorczynski, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.


Life Coaching As An Intervention For Individuals With Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow Jan 2013

Life Coaching As An Intervention For Individuals With Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.


Linking Veterinary And Human Public Health Education: Collaborations At The University Of Tennessee, Nancy Howell, C Hamilton, William Kelch, John New, James Brace, Linda Lane Jul 2012

Linking Veterinary And Human Public Health Education: Collaborations At The University Of Tennessee, Nancy Howell, C Hamilton, William Kelch, John New, James Brace, Linda Lane

James J Brace

The increasing demand for veterinarians in public health has created an environment for innovative educational approaches, providing opportunities for veterinary students to gain additional education in public health. At the University of Tennessee, this environment has enabled a collaboration between the College of Veterinary Medicine and the College of Education, Health, and Human Sciences to establish a veterinary concentration in an existing Master of Public Health degree program. The veterinary public-health concentration was approved in 2004. In addition, other courses and initiatives have been developed at the College of Veterinary Medicine, creating stronger collaborations with academic units and public-health professionals.


Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching, India Lane, Elizabeth Strand, Mchael Sims, Nancy Howell Apr 2012

Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching, India Lane, Elizabeth Strand, Mchael Sims, Nancy Howell

India F. Lane

No abstract provided.


Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching (Abstract), India Lane, Elizabeth Strand, Michael Sims, Nancy Howell Apr 2012

Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching (Abstract), India Lane, Elizabeth Strand, Michael Sims, Nancy Howell

India F. Lane

No abstract provided.


Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching, India Lane, Elizabeth Strand, Mchael Sims, Nancy Howell Mar 2012

Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching, India Lane, Elizabeth Strand, Mchael Sims, Nancy Howell

Elizabeth Strand, PhD, LCSW

No abstract provided.


Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching (Abstract), India Lane, Elizabeth Strand, Michael Sims, Nancy Howell Mar 2012

Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching (Abstract), India Lane, Elizabeth Strand, Michael Sims, Nancy Howell

Elizabeth Strand, PhD, LCSW

No abstract provided.


Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching (Abstract), India Lane, Elizabeth Strand, Michael Sims, Nancy Howell Mar 2012

Our Professional Responsibility In Clinical Competency: The Role Of Quality Clinical Teaching (Abstract), India Lane, Elizabeth Strand, Michael Sims, Nancy Howell

Michael H. Sims

No abstract provided.


Pharmacokinetics Of Orally Administered Tramadol In Domestic Rabbits (Oryctolagus Cuniculus), Marcy Souza, Cheryl Greenacre, S Cox Jan 2012

Pharmacokinetics Of Orally Administered Tramadol In Domestic Rabbits (Oryctolagus Cuniculus), Marcy Souza, Cheryl Greenacre, S Cox

Cheryl B Greenacre DVM

OBJECTIVE:To determine the pharmacokinetics of an orally administered dose of tramadol in domestic rabbits (Oryctolagus cuniculus). ANIMALS: 6 healthy adult sexually intact female New Zealand White rabbits. PROCEDURES: Physical examinations and plasma biochemical analyses were performed to ensure rabbits were healthy prior to the experiment. Rabbits were anesthetized with isoflurane, and IV catheters were placed in a medial saphenous or jugular vein for collection of blood samples. One blood sample was collected before treatment with tramadol. Rabbits were allowed to recover from anesthesia a minimum of 1 hour before treatment. Then, tramadol (11 mg/kg, PO) was administered once ...


Comparison Of Avian Biochemical Test Results With Abaxis Vetscan And Hitachi 911 Analyzers, Cheryl Greenacre, B Flatland, Marcy Souza, Michael Fry Jan 2012

Comparison Of Avian Biochemical Test Results With Abaxis Vetscan And Hitachi 911 Analyzers, Cheryl Greenacre, B Flatland, Marcy Souza, Michael Fry

Cheryl B Greenacre DVM

To compare results of clinical biochemical analysis using an Abaxis VetScan bench-top analyzer with reagents specifically marketed for avian use and a Hitachi 911 analyzer, plasma (both methods) and whole blood (VetScan method) samples from 20 clinically healthy Hispaniolan Amazon parrots (Amazona ventralis) were analyzed. Correlation between methods was very high (r = 0.9-1.0) for aspartate aminotransferase (AST), calcium, glucose, and uric acid; high (r = 0.7-0.89) for creatine kinase (CK), phosphorus, potassium, and total protein; moderate (r = 0.5-0.69) for globulin; and low (r = 0.3-0.49) for albumin and sodium. VetScan analyzer results for globulin ...


Flow Cytometric Evaluation Of Multidrug Resistance Proteins On Grossly Normal Canine Nodal Lymphocyte Membranes, S Schleis, Amy Leblanc, Nancy Nielson, Casey Leblanc Jan 2012

Flow Cytometric Evaluation Of Multidrug Resistance Proteins On Grossly Normal Canine Nodal Lymphocyte Membranes, S Schleis, Amy Leblanc, Nancy Nielson, Casey Leblanc

Casey J. LeBlanc DVM, PhD, DACVP

OBJECTIVE: To demonstrate efficacy of flow cytometric evaluation of expression and activity of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) efflux pumps and characterize and correlate their expression and activity in grossly normal canine nodal lymphocytes. SAMPLE POPULATION: Nodal lymphocytes from 21 clinically normal dogs. PROCEDURES: Pump expression was assessed by use of fluorescent-labeled mouse antihuman P-gp (C494) and MRP1 (MRPm6) antibodies and expressed as median values (antibody value divided by isotype control value). The P-gp and MRP activities were assessed by measuring cellular retention of rhodamine 123 and 5(6)-carboxyfluorescein diacetate in the absence and presence of inhibitors ...


Large Anaplastic Spinal B-Cell Lymphoma In A Cat, Bente Flatland, Michael Fry, Shelley Newman, P Moore, J Smith, William Thomas, R Casimir Jan 2012

Large Anaplastic Spinal B-Cell Lymphoma In A Cat, Bente Flatland, Michael Fry, Shelley Newman, P Moore, J Smith, William Thomas, R Casimir

Bente Flatland

A 5-year-old female spayed domestic shorthair cat was presented for evaluation of tetraparesis. The neurologic lesion was localized to the cervical spinal segment (C1-C6). A left axillary mass was identified, and the results of fine needle aspiration cytology indicated malignant round cell neoplasia of possible histiocytic origin. The cells were large, had marked anisocytosis and anisokaryosis, occasional bi- and multinucleation, and cytoplasmic vacuolation. Euthanasia was performed due to the poor prognosis associated with severe, progressive neurologic signs and a malignant neoplasm. Postmortem examination revealed spinal cord compression and an extradural mass at the C1-C2 spinal segment, with neoplastic cells in ...


Evaluation Of Antibodies Against Feline Coronavirus 7b Protein For Diagnosis Of Feline Infectious Peritonitis In Cats, Melissa Kennedy, M Abd-Eldaim, S Zika, Joseph Mankin, Stephen Kania Jan 2012

Evaluation Of Antibodies Against Feline Coronavirus 7b Protein For Diagnosis Of Feline Infectious Peritonitis In Cats, Melissa Kennedy, M Abd-Eldaim, S Zika, Joseph Mankin, Stephen Kania

Melissa A. Kennedy

OBJECTIVE: To determine whether expression of feline coronavirus (FCoV) 7b protein, as indicated by the presence of specific serum antibodies, consistently correlated with occurrence of feline infectious peritonitis (FIP) in cats. SAMPLE POPULATION: 95 serum samples submitted for various diagnostic assays and 20 samples from specific-pathogen-free cats tested as negative control samples. PROCEDURES: The 7b gene from a virulent strain of FCoV was cloned into a protein expression vector. The resultant recombinant protein was produced and used in antibody detection assays via western blot analysis of serum samples. Results were compared with those of an immunofluorescence assay (IFA) for FCoV-specific ...


Global Food Systems And Public Health : Production Methods And Animal Husbandry, A National Commission On Industrial Farm Animal Production Report. Pew Commission On Industrial Farm Animal Production, M Salman, John New, M Bailey, Corrie Brown, L Detwiler, D Galligan, C Hall, Melissa Kennedy, G Lonergan, L Mann, D Renter, M Saeed, B White, S Zika Jan 2012

Global Food Systems And Public Health : Production Methods And Animal Husbandry, A National Commission On Industrial Farm Animal Production Report. Pew Commission On Industrial Farm Animal Production, M Salman, John New, M Bailey, Corrie Brown, L Detwiler, D Galligan, C Hall, Melissa Kennedy, G Lonergan, L Mann, D Renter, M Saeed, B White, S Zika

Melissa A. Kennedy

No abstract provided.


Transient Type 2 Diabetes Mellitus In A Raccoon (Procyon Lotor), Stephanie Mccain, Claudia Kirk, Edward Ramsay Dec 2011

Transient Type 2 Diabetes Mellitus In A Raccoon (Procyon Lotor), Stephanie Mccain, Claudia Kirk, Edward Ramsay

Claudia A Kirk

A privately owned, obese, adult female raccoon (Procyon lotor) presented with polyuria, polydipsia, weight loss, and increased appetite. Diabetes mellitus was diagnosed based on laboratory findings, including hyperglycemia and glucosuria. As a result of the raccoon's age and obesity at the onset of clinical signs, the raccoon was thought to have type 2 diabetes mellitus, a diagnosis that was supported by paired glucose tolerance tests. Treatment consisted of dietary management and daily insulin therapy. The raccoon was gradually weaned off insulin with no return of clinical signs, further verifying the characterization of type 2 diabetes mellitus.


Public Health Informatics, Ardis Hanson, Bruce Levin, David Scott Oct 2011

Public Health Informatics, Ardis Hanson, Bruce Levin, David Scott

Bruce Lubostsky Levin, DrPH, MPH

No abstract provided.


Disease Prevention And Health Promotion, Peter Hurd, Bruce Levin, Ardis Hanson, William Lang Oct 2011

Disease Prevention And Health Promotion, Peter Hurd, Bruce Levin, Ardis Hanson, William Lang

Bruce Lubostsky Levin, DrPH, MPH

When people think of public health, they often think of the development of epidemiology and a famous public health story about John Snow in 1854. What he did was to map the cholera cases in London and then talk with the people to look for common links between their behaviors and the disease. ...Ever since John Snow removed the pump handle from the cholera infected well in London, heralding the start of population-based health care, the world has struggled with the realities of health promotion and disease prevention.


Introduction To Public Health In Pharmacy, Bruce Levin, Peter Hurd, Ardis Hanson Oct 2011

Introduction To Public Health In Pharmacy, Bruce Levin, Peter Hurd, Ardis Hanson

Bruce Lubostsky Levin, DrPH, MPH

This book provides a comprehensive introduction to public health from a pharmacy perspective. Organized into three main sections, Part I presents concepts and issues that pharmacists need in order to develop a knowledge base in public health. Part II examines the connection between pharmacy and public health services, including an overview of the different health services, evaluation and outcome assessment, financing, managed care pharmacy, and pharmacoeconomics. Part III contains chapters that illustrate key applications of public health concepts to pharmacy practice, including law and ethics, cultural perspectives, informatics, emergency preparedness, and education and training. Each chapter is co-authored by a ...