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Articles 1 - 30 of 20196

Full-Text Articles in Medicine and Health Sciences

Level Of Satisfaction Among Food Pantry Clients, Staff/Volunteers, And Directors And Its Association With Client Choice In Food Pantry Layouts, Myranda Dunmire Jan 2019

Level Of Satisfaction Among Food Pantry Clients, Staff/Volunteers, And Directors And Its Association With Client Choice In Food Pantry Layouts, Myranda Dunmire

Electronic Theses and Dissertations

Objectives: Food insecurity is an issue in rural communities, particularly among food pantry clients. Food pantries may not provide clients with the opportunity to choose their own foods (client choice), and instead may just give a set amount and type of foods. Client choice is important in regards to client health status as well as perceptions of autonomy and quality of life. Although client choice can be promoted in food pantries, it may be difficult to grasp the process of food pantry transitioning and how well changes such as these may be perceived by clients or food pantry personnel. We ...


Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R, Sean Stacey Dec 2018

Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R, Sean Stacey

Electronic Theses and Dissertations

Pseudomonas aeruginosa is a Gram-negative bacillus able to colonize a wide variety of environments. In the human host, P. aeruginosa can establish an acute infection or persist and create a chronic infection. P. aeruginosa is able to establish a niche and persist in human hosts by using a wide array of virulence factors used for: movement, killing host cells, and evading immune cells and antibiotics. Understanding virulence factors and their regulation has proved to be an important means of combating the morbidity and mortality of P. aeruginosa as well as the ever-increasing threat of drug resistance. By targeting virulence factors ...


Hypothalamic Circuits In The Control Of Feeding And Emotional Behaviors, Leandra Mangieri Dec 2018

Hypothalamic Circuits In The Control Of Feeding And Emotional Behaviors, Leandra Mangieri

UT GSBS Dissertations and Theses (Open Access)

Feeding results from the integration of both nutritional and affective states, and is guided by complex neural circuitry in the brain. The hypothalamus is a critical center controlling feeding and motivated behaviors. We found that targeted photostimulation of projections from the lateral hypothalamus (LH) to the paraventricular hypothalamus (PVH) in mice elicited voracious feeding and repetitive self-grooming behavior. GABA neurotransmission in the LH->PVH circuit mediated the evoked feeding behavior, and elicited behavioral approach, whereas glutamate release promoted repetitive self-grooming, which was stress-related in nature. Optogenetic inhibition of LHGABA ->PVH circuit reduced feeding after fasting, whereas photostimulation abruptly stopped ...


Phr: Patient Health Record, Quinn Nelson Dec 2018

Phr: Patient Health Record, Quinn Nelson

Theses/Capstones/Creative Projects

The rapid development of information technology systems has expanded into multiple disciplines and results in systems that are limited by initial design and implementation: the Healthcare Information Technology (HIT) space is no different. The introduction of the Electronic Health Record (EHR) system has changed the way healthcare operates. Initial designs of these systems were focused on serving the needs of insurance companies and healthcare billing departments. Research shows that the design of EHR systems negatively impact provider-patient interactions and the care they receive. This capstone project capitalizes on the collaboration efforts between UNO and UNMC – by joining a research group ...


The Study Of Alcoholic Liver Diseases, Seun Emmanuel Owoseni Dec 2018

The Study Of Alcoholic Liver Diseases, Seun Emmanuel Owoseni

Electronic Theses and Dissertations

Excessive alcohol consumption is the primary contributing factor in the development of alcoholic liver diseases (ALD). Nicotine contained in tobacco is a major addictive alkaloid, which enhances the effects of ALDs. The major enzyme involved in nicotine metabolism is cytochrome P450 2A5 (CYP2A5) which is produced in the liver. Alcohol can stimulate the CYP2A5 enzyme. We utilized cyp2a5-/- knockout mice in this research to examine the effects of CYP2A5.

The cyp2a5-/- mice and wild-type (WT) mice were fed liquid ethanol diet with or without nicotine to induce ALD. Nicotine enhancing effects on ALD were observed in WT mice but not ...


Bacterial Abundance And Resistance In Ground Beef Varieties, Savannah Kumar, Sarah M. Boomer Nov 2018

Bacterial Abundance And Resistance In Ground Beef Varieties, Savannah Kumar, Sarah M. Boomer

PURE Insights

Raw ground beef purchased at supermarkets across America have one thing in common: they harbor bacteria, some of which are drug resistant and can be detrimental to public health. To understand the impact of farming and processing practices on the quantity of bacteria and drug resistance, organic and regular beef were assessed using MacConkey media. Bacterial colonies were sorted according to lactose utilization, with positive colonies representing fecal E. coli. Lactose negative colonies were further characterized into one of two groups (fecal Hafnia-like or soil Pseudomonas) using a variety of metabolic tests (oxidase, sulfur, indole). Advanced metabolic testing showed that ...


An Academia-Industry Partnership For Planning And Executing A Community-Based Feeding Study, Cara B. Ebbeling, Gloria L. Klein, Julia M W Wong, Lisa Bielek, Patricia K. Louto, David S. Ludwig, Ralph G. Eddy, Lauren Stone, Paul R. Lakin, Megan Sandman, Courtenay Devlin, Linda Seger-Shippee, Dina Wiroll Nov 2018

An Academia-Industry Partnership For Planning And Executing A Community-Based Feeding Study, Cara B. Ebbeling, Gloria L. Klein, Julia M W Wong, Lisa Bielek, Patricia K. Louto, David S. Ludwig, Ralph G. Eddy, Lauren Stone, Paul R. Lakin, Megan Sandman, Courtenay Devlin, Linda Seger-Shippee, Dina Wiroll

(FS)2 Scholarly Publications

A research team from Boston Children’s Hospital and Harvard Medical School conducted a community-based feeding study in collaboration with Framingham State University (FSU) and Sodexo, the food service contractor at FSU. The study was a randomized controlled trial, implemented on the FSU campus. For the final year of the study, a satellite feeding site was established at Assabet Valley Regional Technical High School. The purpose of the study was to assess the biological effects of different macronutrient diets. An academia-industry partnership was developed to overcome common challenges associated with hospital-based feeding studies. Benefits included the following: a study site ...


Detection Of Correlated Hidden Factors From Single Cell Transcriptomes Using Iteratively Adjusted-Sva (Ia-Sva)., Donghyung Lee, Anthony Cheng, Nathan Lawlor, Mohan Bolisetty, Duygu Ucar Nov 2018

Detection Of Correlated Hidden Factors From Single Cell Transcriptomes Using Iteratively Adjusted-Sva (Ia-Sva)., Donghyung Lee, Anthony Cheng, Nathan Lawlor, Mohan Bolisetty, Duygu Ucar

Faculty Research 2018

Single cell RNA-sequencing (scRNA-seq) precisely characterizes gene expression levels and dissects variation in expression associated with the state (technical or biological) and the type of the cell, which is averaged out in bulk measurements. Multiple and correlated sources contribute to gene expression variation in single cells, which makes their estimation difficult with the existing methods developed for batch correction (e.g., surrogate variable analysis (SVA)) that estimate orthogonal transformations of these sources. We developed iteratively adjusted surrogate variable analysis (IA-SVA) that can estimate hidden factors even when they are correlated with other sources of variation by identifying a set of ...


Examining Delayed Onset Of Dementia In The Bilingual Geriatric Population, Erica Brown, Elizabeth Hartman Nov 2018

Examining Delayed Onset Of Dementia In The Bilingual Geriatric Population, Erica Brown, Elizabeth Hartman

Grace Peterson Nursing Research Colloquium

Background: Dementia is the largest cause of dependency and disability in older adults, affecting nearly 50 million people worldwide with about 10 million new cases every year. Presently, there are no cures for dementia. Consequently, a growing body of evidence suggests that bilingualism may delay the onset of clinical dementia symptoms by several years.

Objectives: The purpose of this review is to summarize and analyze current evidence from studies that examined how bilingualism delays the onset of dementia. Evidence is reviewed suggesting that bilingualism may delay the dementia symptoms due to an increase in cognitive reserve, which refers to an ...


My Experience In Swaziland With Give Hope, Fight Poverty, Megan Kaser Nov 2018

My Experience In Swaziland With Give Hope, Fight Poverty, Megan Kaser

Purdue Journal of Service-Learning and International Engagement

Megan Kaser, a recent 2017 alum in the College of Health and Human Sciences at Purdue University, describes her experience with Give Hope, Fight Poverty (GHFP)—a nonprofit organization in Indianapolis, Indiana. She is currently pursuing a master’s degree in physician assistant studies. GHFP’s mission is “to foster philanthropy domestically by designing service-learning programs that engage U.S. college students with rural communities in Swaziland, Africa, and work together to educate, empower, and lift orphaned and vulnerable children—particularly those living in child-headed households— out of poverty” (Give Hope, Fight Poverty, n.d.). By incorporating college students in ...


The Pharmaceutical Industry: A Pharmacy Student's Guide, Christian Egly, Yaman Kaakeh Nov 2018

The Pharmaceutical Industry: A Pharmacy Student's Guide, Christian Egly, Yaman Kaakeh

Purdue Journal of Service-Learning and International Engagement

Christian Egly is a fourth-year (P4) pharmacy student in the Purdue University College of Pharmacy. During his years at Purdue, he worked in labs performing bench research in clinical pharmacology and biochemistry. He plans to work in the pharmaceutical industry after graduation. During his fourth year, he completed rotations in business development at Kashiv Pharma, LLC, and was hired there for an internship in 2017. In the article, Christian describes his personal experiences at Kashiv Pharma, LLC, and how industry can positively affect patient communities.


Funding Opportunities Specifically For Early Career Unh Investigators: Science, Technology, Engineering, And Math (Stem) – Sponsors Other Than Federal Agencies -- 11.14.18, Lynnette Hentges Nov 2018

Funding Opportunities Specifically For Early Career Unh Investigators: Science, Technology, Engineering, And Math (Stem) – Sponsors Other Than Federal Agencies -- 11.14.18, Lynnette Hentges

Early Career Investigators

This comprehensive list of funding opportunities specifically for early career investigators offered by foundations and other nonprofit sponsors that are appropriate for UNH researchers working in the areas of science, technology, engineering, and math provides information about program focus, eligibility requirements, funding amount and time period, as well as deadlines and links to program web sites and application instructions.


Funding Opportunities Specifically For Early Career Unh Investigators: Science, Technology, Engineering, And Math (Stem) – Federal Agencies -- 11.14.18, Lynnette Hentges Nov 2018

Funding Opportunities Specifically For Early Career Unh Investigators: Science, Technology, Engineering, And Math (Stem) – Federal Agencies -- 11.14.18, Lynnette Hentges

Early Career Investigators

This comprehensive list of funding opportunities for early career investigators offered by federal agencies that are appropriate for UNH researchers working in the areas of science, technology, engineering, and math provides information about program focus, eligibility requirements, funding amount and time period, as well as deadlines and links to program web sites and application instructions.

Opportunities available from the National Institutes of Health (NIH) are listed separately.


Funding-Opportunities-And-Strategies-For-Early-Career 11.15.18, Lynnette Hentges Nov 2018

Funding-Opportunities-And-Strategies-For-Early-Career 11.15.18, Lynnette Hentges

Early Career Investigators

Slides and handouts from the November 15, 2018 workshop that presented strategies and resources for taking advantage of the special funding opportunities provided to early-career scholars by federal agencies, not-for-profits, professional societies, and other sponsors


Does A Vegan Diet Contribute To Prevention Or Maintenance Of Diseases?, Malia K. Burkholder, Danae A. Fields Nov 2018

Does A Vegan Diet Contribute To Prevention Or Maintenance Of Diseases?, Malia K. Burkholder, Danae A. Fields

Kinesiology and Allied Health Senior Research Projects

This literature review deals with the topic of, does a vegan diet contribute to prevention or maintenance of diseases? Our main focus was to look at what a vegan diet entailed, the history of veganism, and why people decide to adhere to this diet type. Multiple research studies were looked over on the topics of how a vegan diet effects the disease processes of cancer, diabetes, gastral intestinal issues, weight loss, and heart disease. The overall arching theme that was found in the research is that a vegan diet is beneficial in helping to lessen the risk or aid in ...


Effects Of A Low Carbohydrate Diet On Energy Expenditure During Weight Loss Maintenance: Randomized Trial, Cara B. Ebbeling, Henry A. Feldman, Gloria L. Klein, Julia M.W. Wong, Lisa Bielek Bielek, Sarah K. Steltz, Patricia K. Louto, Robert R. Wolfe, William W. Wong, David S. Ludwig Nov 2018

Effects Of A Low Carbohydrate Diet On Energy Expenditure During Weight Loss Maintenance: Randomized Trial, Cara B. Ebbeling, Henry A. Feldman, Gloria L. Klein, Julia M.W. Wong, Lisa Bielek Bielek, Sarah K. Steltz, Patricia K. Louto, Robert R. Wolfe, William W. Wong, David S. Ludwig

(FS)2 Scholarly Publications

From the abstract "OBJECTIVE To determine the effects of diets varying in carbohydrate to fat ratio on total energy expenditure. DESIGN Randomized trial. SETTING Multicenter collaboration at US two sites, August 2014 to May 2017. PARTICIPANTS 164 adults aged 18-65 years with a body mass index of 25 or more. INTERVENTIONS After 12% (within 2%) weight loss on a run-in diet, participants were randomly assigned to one of three test diets according to carbohydrate content (high, 60%, n=54; moderate, 40%, n=53; or low, 20%, n=57) for 20 weeks. Test diets were controlled for protein and were energy ...


Case Study: Robin Hood Or Criminal? The Case Of A Bank Loan Officer, Vincent Agnello, Joseph F. Winter, Hai Ta Nov 2018

Case Study: Robin Hood Or Criminal? The Case Of A Bank Loan Officer, Vincent Agnello, Joseph F. Winter, Hai Ta

Journal of Vincentian Social Action

Employees who deviate from established rules at work face suspension or termination from their employment. Yet, knowing these dire consequences employees may still find themselves walking on a different path of business policy. Most employee wrongful conduct is done with the specific intent of benefitting the employee. In some cases, the authorities are brought in to intervene and criminal charges are brought against the employee, as in the case of embezzlement. Some acts are done by employees who do not believe in their company’s rules and are willing to deviate from them, not for their own benefit, but rather ...


Usury And The Common Good, Jim Wishloff Nov 2018

Usury And The Common Good, Jim Wishloff

Journal of Vincentian Social Action

No abstract provided.


Table Of Contents Nov 2018

Table Of Contents

Journal of Vincentian Social Action

No abstract provided.


Editors Nov 2018

Editors

Journal of Vincentian Social Action

No abstract provided.


Cover Nov 2018

Cover

Journal of Vincentian Social Action

No abstract provided.


Pornography’S Effect On The Brain: A Review Of Modifications In The Prefrontal Cortex, Kendra J. Muller Nov 2018

Pornography’S Effect On The Brain: A Review Of Modifications In The Prefrontal Cortex, Kendra J. Muller

Intuition: The BYU Undergraduate Journal in Psychology

Pornography use has exponentially increased in the past 10 years. Most believe pornography use is largely a harmless behavior. Although sexuality is innate, hyper-sexual behavior, such as pornography use, has become increasingly commonplace. Addiction research has found that long-term substance addiction contributes to changes in brain volume (Hong et al., 2013; Zhou et al., 2011). Recent studies have shown that behavioral addictions also have similar volume loss as substance abuse (Hong et al., 2013). Research has shown that the particular area most affected is the prefrontal cortex (Hong et al., 2013). The prefrontal cortex, which oversees regulating self-control, decreases in ...


No Evidence For Kin Protection In The Expression Of Sickness Behaviors In House Mice, Patricia C. Lopes, Per Block, Alice Pontiggia, Anna K. Lindholm, Barbara König Nov 2018

No Evidence For Kin Protection In The Expression Of Sickness Behaviors In House Mice, Patricia C. Lopes, Per Block, Alice Pontiggia, Anna K. Lindholm, Barbara König

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When infected, animals change their behaviors in several ways, including by decreasing their activity, their food and water intake, and their interest in social interactions. These behavioral alterations are collectively called sickness behaviors and, for several decades, the main hypotheses put forward to explain this phenomenon were that engaging in sickness behaviors facilitated the fever response and improved the likelihood of host survival. However, a new hypothesis was recently proposed suggesting that engaging in sickness behaviors may serve to protect kin. We tested this kin protection hypothesis by combining a field and a laboratory experiment in house mice. In both ...


Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting Both Immune Suppression And Oncogenic Cell Proliferation., Pachiappan Arjunan, Mohamed M Meghil, Wenhu Pi, Jinxian Xu, Liwei Lang, Ahmed El-Awady, William Sullivan, Mythilypriya Rajendran, Mariana Sousa Rabelo, Tong Wang, Omnia K Tawfik, Govindarajan Kunde-Ramamoorthy, Nagendra Singh, Thangaraju Muthusamy, Cristiano Susin, Yong Teng, Roger M Arce, Christopher W Cutler Nov 2018

Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting Both Immune Suppression And Oncogenic Cell Proliferation., Pachiappan Arjunan, Mohamed M Meghil, Wenhu Pi, Jinxian Xu, Liwei Lang, Ahmed El-Awady, William Sullivan, Mythilypriya Rajendran, Mariana Sousa Rabelo, Tong Wang, Omnia K Tawfik, Govindarajan Kunde-Ramamoorthy, Nagendra Singh, Thangaraju Muthusamy, Cristiano Susin, Yong Teng, Roger M Arce, Christopher W Cutler

Faculty Research 2018

Chronic periodontitis (CP) is a microbial dysbiotic disease linked to increased risk of oral squamous cell carcinomas (OSCCs). To address the underlying mechanisms, mouse and human cell infection models and human biopsy samples were employed. We show that the 'keystone' pathogen Porphyromonas gingivalis, disrupts immune surveillance by generating myeloid-derived dendritic suppressor cells (MDDSCs) from monocytes. MDDSCs inhibit CTLs and induce FOXP3 + T


Modeling In The Physiology Classroom, Sowmya Anjur Nov 2018

Modeling In The Physiology Classroom, Sowmya Anjur

Faculty Publications & Research

Physiology and Disease is a Biology elective at IMSA that has been developed to be mostly student-centered. Some examples of student projects include modeling heart structure to reflect function and creating LED arduino monitors to measure heart rate. Students also measure their lung capacity and blood pressure to demonstrate correlation of these values with heart rate, and trace the correlation back to neuronal controls. Projects such as these integrate other disciplines such as engineering and conform to NGSS Science and Engineering standards and NGSS Cross cutting Concepts standards. Students take responsibility for their own learning and articulate better on tests.


Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater Nov 2018

Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater

Posters-at-the-Capitol

Immunotherapy strategies are very promising treatments for cancer patients. Specifically, Immune checkpoint inhibitor therapy focusing on the PD-1/PD-L1 pathway shows long-lasting positive results in many cancer patients. Unfortunately, not all the patients can benefit from this highly effective treatment. Hence, there is a great need for predictive biomarkers. Immunohistochemical (IHC) staining has been used as a way of predicting patient response, yet shows many problems. For example, IHC utilizes an invasive biopsy and sample fixing, which creates an incomplete and delayed picture of the patient’s biochemistry and the tumor microenvironment, consequently ignoring metastases.

The purpose of this study ...


The Critical Need For Mental Health Education To Be Mandated In New Mexico's Public Schools, Bonnie L. Murphy Nov 2018

The Critical Need For Mental Health Education To Be Mandated In New Mexico's Public Schools, Bonnie L. Murphy

Shared Knowledge Conference

Based on a review of research and best practices in mental health awareness and skills, this inquiry project argues for state legislative policies that would require mental health awareness and skills in the K-12 curriculum. Mental health affects individual accomplishments in every stage of people’s lives beginning in early childhood and throughout the life cycle. Prevention and treatment of mental illness plays a key role in the ability of an individual to cope with loss and develop resiliency and perseverance in challenging times and to make better decisions that improve the individual’s life and the lives of those ...


A Pan-Cancer Analysis Of Driver Gene Mutations, Dna Methylation And Gene Expressions Reveals That Chromatin Remodeling Is A Major Mechanism Inducing Global Changes In Cancer Epigenomes., Ahrim Youn, Kyung In Kim, Raul Rabadan, Benjamin Tycko, Yufeng Shen, Shuang Wang Nov 2018

A Pan-Cancer Analysis Of Driver Gene Mutations, Dna Methylation And Gene Expressions Reveals That Chromatin Remodeling Is A Major Mechanism Inducing Global Changes In Cancer Epigenomes., Ahrim Youn, Kyung In Kim, Raul Rabadan, Benjamin Tycko, Yufeng Shen, Shuang Wang

Faculty Research 2018

BACKGROUND: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies also suggest that CDG mutations contribute to cancer-associated epigenomic and transcriptomic alterations across many cancer types. Here we aim to improve our understanding of the connections between CDG mutations and altered cancer cell epigenomes and transcriptomes on pan-cancer level and how these connections contribute to the known association between epigenome and transcriptome.

METHOD: Using multi-omics data including somatic mutation, DNA methylation, and gene expression data of 20 cancer types from The Cancer Genome Atlas (TCGA) project, we conducted a pan-cancer analysis ...


Writing Ourselves Into Existence: Healing Through Collaborative Curriculum Development, Bianca Ivette Laureano, Sara C. Flowers Drph Nov 2018

Writing Ourselves Into Existence: Healing Through Collaborative Curriculum Development, Bianca Ivette Laureano, Sara C. Flowers Drph

Journal of Critical Thought and Praxis

Here we offer an open exchange / evaluation of our experience as facilitator and editor (Bianca) and writer and collaborator (Sara) during the inaugural Women of Color Sexual Health Network Curriculum Lab which took place November 2017 in New Orleans, LA. In two months, 7 women and femmes of color who are sexuality educators wrote a robust curriculum for our communities that centers pleasure, social emotional learning competencies as early Freedom Schools implemented, sex and pleasure positive, using an intersectional framework and praxis, disability justice framework, inclusive of LGBTQ communities, and does not assume HIV negative status. This is one of ...


Role Of Noise And Parametric Variation In The Dynamics Of Gene Regulatory Circuits., Vivek Kohar, Mingyang Lu Nov 2018

Role Of Noise And Parametric Variation In The Dynamics Of Gene Regulatory Circuits., Vivek Kohar, Mingyang Lu

Faculty Research 2018

Stochasticity in gene expression impacts the dynamics and functions of gene regulatory circuits. Intrinsic noises, including those that are caused by low copy number of molecules and transcriptional bursting, are usually studied by stochastic simulations. However, the role of extrinsic factors, such as cell-to-cell variability and heterogeneity in the microenvironment, is still elusive. To evaluate the effects of both the intrinsic and extrinsic noises, we develop a method, named sRACIPE, by integrating stochastic analysis with random circuit perturbation (RACIPE) method. RACIPE uniquely generates and analyzes an ensemble of models with random kinetic parameters. Previously, we have shown that the gene ...