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Current Understanding Of The Mechanism Of Action Of The Antiepileptic Drug Lacosamide, Michael A. Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff 2015 University of California - Davis

Current Understanding Of The Mechanism Of Action Of The Antiepileptic Drug Lacosamide, Michael A. Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff

Michael A. Rogawski

The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a chiral functionalized amino acid, was originally identified by virtue of activity in the mouse and rat maximal electroshock (MES) test. Attention was drawn to lacosamide because of its high oral potency and stereoselectivity. Lacosamide is also active in the 6 Hz seizure model but inactive against clonic seizures in rodents induced by subcutaneous pentylenetetrazol, bicuculline and picrotoxin. It is also ineffective in genetic models of absence epilepsy. At doses greater than those required to confer protection in the MES test, lacosamide inhibits behavioral and electrographic seizures in hippocampal kindled rats. It also effectively ...


Ngo's Bpa Report Intended To Frighten, Not Enlighten., Robert L. Brent Dr. 2015 duPont Hosp for Children

Ngo's Bpa Report Intended To Frighten, Not Enlighten., Robert L. Brent Dr.

The Selected Works of Robert Brent

None


Healthcare Information Systems: Opportunities And Challenges, Madison Ngafeeson 2015 Northern Michigan University

Healthcare Information Systems: Opportunities And Challenges, Madison Ngafeeson

Madison Ngafeeson

No abstract provided.


Cara Hidup Sehat, eyondd wae lee eyondd 2015 eyondd wae lee

Cara Hidup Sehat, Eyondd Wae Lee Eyondd

eyondd wae lee eyondd

Sebuah Cara hidup sehat kualitas dalam hal wanita muda tanpa cacat yang telah diperiksa oleh metode spesialis adalah batas pinggang - pinggul sekitar 0 . tujuh puluh . Fisiologi telah demostrated bahwa wanita dengan jam pasir detail yang lebih matang daripada beberapa wanita muda yang berbeda berdasarkan langkah-langkah yang lebih baik dari hormon manusia perempuan tertentu , realitas yang akan pria sadar keadaan memilih kaki . Orang-orang yang dibangkitkan oleh gambar banyak individu mengungkap dalam media untuk menemukan apa yang tegas atau sama sekali tidak sempurna . Beberapa feminis dan tambahan dokter [ tidak jelas ] menggabungkan diberdayakan yang untuk gelar besar bentuk tipis diperkenalkan dalam buku harian ...


Validated Automatic Brain Extraction Of Head Ct Images, John Muschelli III, Natalie L. Ullman, Daniel F. Hanley, Paul Vespa, Ciprian M. Crainiceanu 2015 Johns Hopkins University

Validated Automatic Brain Extraction Of Head Ct Images, John Muschelli Iii, Natalie L. Ullman, Daniel F. Hanley, Paul Vespa, Ciprian M. Crainiceanu

John Muschelli III

Background

X-ray Computed Tomography (CT) imaging of the brain is commonly used in diagnostic settings. Al- though CT scans are primarily used in clinical practice, they are increasingly used in research. A fundamental processing step in brain imaging research is brain extraction – the process of separating the brain tissue from all other tissues. Methods for brain extraction have either been validated but not fully automated, or have been fully automated and informally proposed, but never formally validated.

Aim

To systematically analyze and validate the performance of FSL’s brain extraction tool (BET) on head CT images of patients with intracranial ...


Web-Based Personalized Feedback: Is This An Appropriate Approach For Reducing Drinking Among High School Students?, Diana M. Doumas 2015 Boise State University

Web-Based Personalized Feedback: Is This An Appropriate Approach For Reducing Drinking Among High School Students?, Diana M. Doumas

Counselor Education Faculty Publications and Presentations

Research indicates brief web-based personalized feedback interventions are effective in reducing alcohol use and the negative associated consequences among college students. It is not clear, however, that this is an appropriate strategy for high school students. This study examined high school students’ perceptions of a brief web-based personalized feedback program to assess the appropriateness of this approach for this age group. Results indicated that the majority of students found the program to be user-friendly and to have high utility. Additionally, students reporting alcohol use found the program more useful and indicated they would be more likely to recommend the program ...


Postcolonial Disability In Mohesen Makhmalbaf’S Kandahar, Sukshma Vedere 2015 George Washington University

Postcolonial Disability In Mohesen Makhmalbaf’S Kandahar, Sukshma Vedere

Ray Browne Conference on Cultural and Critical Studies

Kandahar (2001), an Iranian film directed by Mohsen Makhmalbaf, details the journey of the protagonist, Nafas, to Kandahar to save her sister from committing suicide on the day of the solar eclipse. The film has gained recent attention by disability studies scholars for the representation of disability in Afghanistan; scholars have discussed the significance of prosthetics and international aid for the disabled in post-war zones of the Third World, but little has been said about disability as a postcolonial embodiment. I argue that Kandahar represents the postcolonial state as a disabled space both literally and metaphorically. It projects the veil ...


New Services To Enhance A Health Care Network's Reputation: Digital Commons At Lvhn, A Health Network Experience, Kristine A. Petre MLS, CM, AHIP 2015 Lehigh Valley Health Network

New Services To Enhance A Health Care Network's Reputation: Digital Commons At Lvhn, A Health Network Experience, Kristine A. Petre Mls, Cm, Ahip

Division of Education

Live for a little over two years, Lehigh Valley Health Network’s repository, LVHN Scholarly Works, has enhanced the Network’s reputation and research credibility by increasing the visibility of its scholarship. In addition to enhancing the Network’s reputation, LVHN Scholarly Works has been instrumental in saving time and easing workflows for several of its residency programs as well as for ACGME accreditation, and has even contributed to filling in missing pieces of institutional history. As the initiative moves forward, the library continues to look for ways to further increase the visibility of LVHN’s scholarship and help to ...


Clinical Outcomes Of Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Brian L. Phee 2015 The University of Western Ontario

Clinical Outcomes Of Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Brian L. Phee

University of Western Ontario - Electronic Thesis and Dissertation Repository

Objective: To evaluate clinical and radiographic treatment outcomes after maxillomandibular advancement (MMA) surgery on subjects suffering from obstructive sleep apnea (OSA).

Materials and Methods: This was a retrospective cohort analysis. Subjects underwent pre- and post-surgical polysomnography (PSG) studies and were also asked to complete a subjective self-assessment via the Epworth Sleepiness Scale (ESS) questionnaire. Twenty-two patients (11 male, 11 female) met the inclusion criteria.

Results: The mean pre-surgical apnea-hypopnea index (AHI) score was 48.4 (+/-31.3) and mean ESS score was 11.6 (+/-4.6). After surgery, the mean AHI reduced to 14.0 (+/-15.0) and ESS reduced ...


Mri Is The Most Effective Initial Diagnostic Study For Osteomyelitis Of The Foot In Diabetic Patients, Anthony M. Provenzano B.A. 2015 Wayne State University

Mri Is The Most Effective Initial Diagnostic Study For Osteomyelitis Of The Foot In Diabetic Patients, Anthony M. Provenzano B.A.

Clinical Research in Practice: The Journal of Team Hippocrates

What is the best initial diagnostic study that should be used for a suspected osteomyelitis diagnosis? A critical review and clinical application of: Kapoor A, Page S, LaValley M, Gale DR, Felson DT. Magnetic resonance imaging for diagnosing foot osteomyelitis: a meta-analysis. Arch Intern Med. 2007;167(2):125-132. doi:10.1001/archinte.167.2.125.


Historical Perspectives On The Care And Treatment Of The Mentally Ill, Albert R. Roberts, Linda Farms Kurtz 2015 Indiana University

Historical Perspectives On The Care And Treatment Of The Mentally Ill, Albert R. Roberts, Linda Farms Kurtz

The Journal of Sociology & Social Welfare

An examination of the history of mental illness and its treatment over the centuries reveals that the mentally ill have few advocates except each other and that their treatment has consisted of confinement and neglect. Reformers have pioneered for change, experienced brief success, but ultimately conditions for the mentally ill regress. Society continues to abhor mental illness as though its collective consciousness still believes in possession by evil spirits. Discussion of the early history moves from banishment to ships of fools, to European asylums, and to institutions run by the states in America. More recent history focuses on the National ...


Reconsidering Drug Involvement Among Youth And Young Adults: Implications For Targeted Primary Prevention, Mark W. Fraser 2015 University of Utah

Reconsidering Drug Involvement Among Youth And Young Adults: Implications For Targeted Primary Prevention, Mark W. Fraser

The Journal of Sociology & Social Welfare

The purpose of this; paper is to review two dominant social perspectives on the etiology of substance abuse among youths and young adults-the stage and risk factor outlooks-and to discuss them in light of recent demographic and ecological research. The differential demography of drug abuse strongly suggests that the environmental context influences the use and abuse of substances. In an era of great public concern about substance abuse, the use of individually-focused perspectives appears to have resulted in person-centered skills training programs and "say no" media campaigns. Consideration of community-level factors in the etiology of drug abuse permits the identification ...


Community-Based Self-Help Groups For The Treatment Of Agoraphobia, Bruce A. Thyer 2015 Florida State University

Community-Based Self-Help Groups For The Treatment Of Agoraphobia, Bruce A. Thyer

The Journal of Sociology & Social Welfare

The design and conduct of community-based self-help groups for the treatment of agoraphobia are discussed. Such groups incorporate procedures encouraging members to engage in prolonged therapeutic exposure to anxiety-evoking situations. Exposure therapy and its variants have been empirically established as the treatment of choice for agoraphobia, and self-help groups lend themselves extremely well to community mental health outreach and service efforts.


Style Guide: An Interdisciplinary Communication Tool To Support The Process Of Generating Tailored Infographics From Electronic Health Data Using Entice3, Adriana Arcia, Mark Velez, Suzanne Bakken 2015 Columbia University

Style Guide: An Interdisciplinary Communication Tool To Support The Process Of Generating Tailored Infographics From Electronic Health Data Using Entice3, Adriana Arcia, Mark Velez, Suzanne Bakken

eGEMs (Generating Evidence & Methods to improve patient outcomes)

Purpose: In this case study we describe key features of the structured communication tool—a style guide—used to support interdisciplinary collaboration, and we propose the use of such a tool for research teams engaged in similar projects. We employ tailored infographics to present patient reported outcome data from a community health survey back, in a comprehensible and actionable manner, to the individuals who provided it. The style guide was developed to bridge the semantic gap between the domain and programming experts engaged in this effort.

Innovation: The style guide supports the communication of complex design specifications in a highly ...


Harris Health System Ems Protocols And Standing Delegation Orders, Richard N. Bradley 2015 The University of Texas Health Science Center at Houston

Harris Health System Ems Protocols And Standing Delegation Orders, Richard N. Bradley

Richard N Bradley

As the EMS Medical Director for Harris Health System-EMS, I have approved these Protocols and Standing Delegation Orders to provide a treatment plan for the various types of injuries and illnesses that may commonly occur. These Protocols and Standing Delegation Orders are not intended to replace on-line Medical Control by a qualified physician, but rather to provide standing orders for specific interventions prior to the point that establishing control with a qualified physician becomes mandatory.

Authorized personnel are those basic and/or advanced life support trained HARRIS HEALTH SYSTEM-EMS personnel who have been approved in writing by the Medical Director ...


American Red Cross Scientific Review On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis, The American Red Cross Scientific Advisory Council 2015 The University of Texas Health Science Center at Houston

American Red Cross Scientific Review On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis, The American Red Cross Scientific Advisory Council

Richard N Bradley

INTRODUCTION: There were 4,700 deaths due to choking in the United States in 2012. This study was a structured literature review with the objective of determining whether in adults, either conscious or unconscious, with acute foreign body airway obstructions, if any specific resuscitation technique, compared to other techniques, leads to different outcomes.

METHODS: We developed an a priori search definition, and searched PubMed, Google, and OneSearch@IU. We sought additional articles by reviewing the reference lists of articles that we included. We included articles if they addressed original research of treatment of foreign body airway obstruction in adults. We ...


American Red Cross Sac Advisory On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis, American Red Cross Scientific Advisory Council 2015 The University of Texas Health Science Center at Houston

American Red Cross Sac Advisory On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis, American Red Cross Scientific Advisory Council

Richard N Bradley

INTRODUCTION: There were 4,700 deaths due to choking in the United States in 2012. This study was a structured literature review with the objective of determining whether in adults, either conscious or unconscious, with acute foreign body airway obstructions, if any specific resuscitation technique, compared to other techniques, leads to different outcomes.

METHODS: We developed an a priori search definition, and searched PubMed, Google, and OneSearch@IU. We sought additional articles by reviewing the reference lists of articles that we included. We included articles if they addressed original research of treatment of foreign body airway obstruction in adults. We ...


Recognizing The Influence Of Social Determinants On Hiv Risk Behaviors And The Need For Structural Interventions To Prevent Hiv In Women, Arlene Edwards 2015 Centers for Disease Control and Prevention

Recognizing The Influence Of Social Determinants On Hiv Risk Behaviors And The Need For Structural Interventions To Prevent Hiv In Women, Arlene Edwards

Journal of Health Disparities Research and Practice

The design and implementation of structural interventions may provide for simultaneous and longitudinal responses to prevention needs in multiple contexts as defined by social determinants, thus varied opportunities exist to respond to the HIV prevention needs of women. According to the CDC, in 2010, the rate of new HIV infections among black women was 20 times that of white women, and the rate among Hispanic/Latino women was 4 times the rate of white women. Additionally, 86% of HIV infections in women were attributed to heterosexual contact and 14% to injection drug use (CDC, 2012). These numbers are reflected outside ...


Common Threads: An Integrated Hiv Prevention And Vocational Development Intervention For African American Women Living With Hiv/Aids, Liza Marie Conyers, Yung-Chen Chiu, Aisha Shamburger-Rousseau, Vanessa Johnson, Mark Misrok 2015 The Pennsylvania State University

Common Threads: An Integrated Hiv Prevention And Vocational Development Intervention For African American Women Living With Hiv/Aids, Liza Marie Conyers, Yung-Chen Chiu, Aisha Shamburger-Rousseau, Vanessa Johnson, Mark Misrok

Journal of Health Disparities Research and Practice

Current policies and initiatives call for the integration of social determinants of health into HIV/AIDS prevention and care interventions. According to the World Health Organization’s Commission on Social Determinants of Health, the lower a person’s socioeconomic status, the worse the health outcomes. One way to alleviate poverty among African American women with HIV/AIDS is to help foster their vocational development and economic empowerment. The National HIV/AIDS Strategy Implementation Plan specifically directs federal agencies to find ways to integrate people living with HIV/AIDS into broader employment initiatives. The purpose of this manuscript is to examine ...


A Comparison Of Sexual Health And Sexual Pressure Among Young African American And Caucasian Women, Ann Gakumo 2015 University of Alabama - Birmingham

A Comparison Of Sexual Health And Sexual Pressure Among Young African American And Caucasian Women, Ann Gakumo

Journal of Health Disparities Research and Practice

Introduction. Condom self-efficacy, positive attitudes toward condom use, condom negotiation skills, HIV knowledge, and self-esteem have been associated with decreased HIV risk behavior among young women, but few studies have examined racial disparities that may exist in these social health indicators. Moreover, sexual pressure (inclusive of both coercive and non-coercive pressures to engage in unwanted or unprotected sex) has been understudied in women of different racial groups.

Study Purpose. The purpose of this study was to compare racial similarities and disparities in indicators of sexual health and sexual pressure in an urban sample of young African American and Caucasian women ...


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