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“I Am The Expert” : The Process Of Adolescent Transition In The Self-Management Of Hearing Healthcare. A Constructivist Grounded Theory Study, Christine N. Meston Apr 2021

“I Am The Expert” : The Process Of Adolescent Transition In The Self-Management Of Hearing Healthcare. A Constructivist Grounded Theory Study, Christine N. Meston

Electronic Thesis and Dissertation Repository

Adolescence is a time when adult behaviours become established and adolescents are more able to manage aspects of their healthcare. Research has examined adolescent transitions to self-manage their personal healthcare needs associated with chronic diseases. Providing children and adolescents with information about their health is an ongoing process and, as they mature, they should be allowed to take on more responsibility for their healthcare management. The purpose of this study was to explore the transition for adolescents who are deaf and hard of hearing toward the self-management of their hearing healthcare. A constructivist grounded theory approach was used to develop ...


Catechol-Containing Copolymers As An Active Ingredient For Denture Adhesives, Vincent Ying Wun Kong Apr 2021

Catechol-Containing Copolymers As An Active Ingredient For Denture Adhesives, Vincent Ying Wun Kong

Electronic Thesis and Dissertation Repository

Moisture inside the mouth adds challenge to making denture adhesives formulations. Some formulations have zinc to enhance adhesion on wet skin despite knowing the health hazards. Inspired by mussel foot proteins’ catechol unit’s strong underwater adhesion, nine catechol-containing copolymers (P1A-P3C) were synthesized by free radical polymerization of 3,4-dimethoxystyrene (3,4- DMS) with different styrene derivatives followed by deprotection. P1A-P3C were used to make Fn(P)-C-PBS denture adhesive formulations which had suitable shear stresses around ≥ 5 kPa satisfying ISO 10873. In-situ NMR studies of free radical polymerization of 3,4 - DMS and styrene derivatives allowed computation of their ...


Hiv-1 Drug Resistance To Integrase Strand Transfer Inhibitors In Hiv-1 Non-B Subtypes, Emmanuel Ndashimye Apr 2021

Hiv-1 Drug Resistance To Integrase Strand Transfer Inhibitors In Hiv-1 Non-B Subtypes, Emmanuel Ndashimye

Electronic Thesis and Dissertation Repository

Human immunodeficiency syndrome (HIV-1) has infected over 75 million people and over 35 million have succumbed to virus related illnesses. Despite access to a variety of antiretroviral therapy (ART) options, ART programs have been disproportionally spread in the world with low-and middle-income countries (LMICs) facing challenges to access the most potent ART options. With less potent ART remaining in use in LMICs, HIV-1 drug resistance (HIVDR) presents a growing challenge in LMICs. Since approval of the first-generation integrase strand transfer inhibitor (INSTIs), Raltegravir (RAL) in 2007, INSTIs remain the best choice as a backbone of ART. Access to second generation ...


Barriers To Safety Planning And Best Practices For Supporting Survivors Of Domestic Violence In Rural, Remote, And Northern Regions, Sara Kohtala Apr 2021

Barriers To Safety Planning And Best Practices For Supporting Survivors Of Domestic Violence In Rural, Remote, And Northern Regions, Sara Kohtala

Electronic Thesis and Dissertation Repository

Domestic violence (DV) or intimate partner violence (IPV) is defined as physical, emotional, psychological, or sexual harm in an intimate relationship. In extreme cases, it may culminate in domestic homicide which is defined as the killing of an intimate partner, their children or their family members. Intimate partner violence and domestic homicide is prevalent worldwide. Over ninety-nine thousand reports of DV were made to police in Canada in 2018. According to the Canadian Domestic Homicide Prevention Initiative for Vulnerable Populations, some victims may face greater barriers in receiving assistance on a timely basis such as immigrants and refugees, Indigenous people ...


Therapist Perception Of The Clarity And Implementability Of Relevant Recommendations From American Academy Of Orthopedic Surgeon’S Distal Radius Fracture Clinical Practice Guidelines, Saravanan Esakki Apr 2021

Therapist Perception Of The Clarity And Implementability Of Relevant Recommendations From American Academy Of Orthopedic Surgeon’S Distal Radius Fracture Clinical Practice Guidelines, Saravanan Esakki

Electronic Thesis and Dissertation Repository

Fractures of the distal radius are common and can cause substantial either transient or permanent impairment and disability.

Clinical practice guidelines (CPGs) are systematically developed statements or recommendations based on the best available evidence and aimed at assisting health care practitioners in clinical decision-making. Many professional organizations have developed practice guidelines for common clinical conditions. The overall objective of this thesis is to evaluate the therapist's perception of the clarity and implementability of rehabilitation relevant recommendations from The American Academy of Orthopaedic Surgeons (AAOS) CPG for distal radius fractures (DRF) and to identify the quality of CPG related to ...


Novel Imaging Tools Reveal The Dynamics Of The Myocardial Growth Hormone Secretagogue Receptor In Heart Disease And Heart Failure, Rebecca Sullivan Apr 2021

Novel Imaging Tools Reveal The Dynamics Of The Myocardial Growth Hormone Secretagogue Receptor In Heart Disease And Heart Failure, Rebecca Sullivan

Electronic Thesis and Dissertation Repository

Heart disease (HD) is the leading cause of mortality worldwide. Currently, diagnosis is based on clinical features, imaging, and circulating cardiac biomarkers. Cardiac imaging technologies, such as echocardiography and cardiac magnetic resonance imaging (cMRI), enable the non-invasive detection of changes in heart function. Although these modalities can detect changes in structure and anatomy, it is usually at later stages, where prevention may not be possible. In conjunction with imaging, circulating biomarkers of heart failure (HF), notably B-type natriuretic peptide (BNP) and cardiac troponin I and T, can be detected with increased levels in the blood. These biomarkers are associated with ...


Experimental, Theoretical, And Translational Studies Of Rbc Distribution In Capillary Networks, Asher Mendelson Mar 2021

Experimental, Theoretical, And Translational Studies Of Rbc Distribution In Capillary Networks, Asher Mendelson

Electronic Thesis and Dissertation Repository

The purpose of this thesis was to evaluate the physiology of red blood cell (RBC) distribution in skeletal muscle capillary networks. Because this is the terminal site of oxygen exchange in the microcirculation, characterization of this fundamental process informs an understanding of how microvascular blood flow regulation matches oxygen supply with local tissue demand. Prior studies in this field have focused on small groups of capillaries, and have not linked capillary network structure with functional measurements, nor evaluated the temporal complexity of RBC distribution over physiologically-relevant scales. It is also unclear how the functional units called capillary modules – comprised of ...


Long-Term Patterns Of Acute Mental Health Service Use After A First Episode Of Psychosis: Examining Ongoing Psychiatric Care Beyond The Critical Period, Eugene Law Mar 2021

Long-Term Patterns Of Acute Mental Health Service Use After A First Episode Of Psychosis: Examining Ongoing Psychiatric Care Beyond The Critical Period, Eugene Law

Electronic Thesis and Dissertation Repository

The long-term patterns of acute mental health service use after treatment in an early psychosis intervention (EPI) program are not well known. The objective of this thesis was to investigate the long-term patterns of acute mental health service use. We used health administrative data to examine the patterns and risk factors associated with acute mental health service use over the of 5- to 10-year period post-EPI admission. Between years 5 to 10 post-EPI admission, approximately one quarter of people contacted acute mental health services. Factors associated with acute mental health service use during this period included younger age at admission ...


Pleurodesis Using Hypertonic Glucose Administration To Treat Post-Operative Air Leaks Following Lung Resection Surgery (Plug): Phase I Trial, Mehdi Qiabi Mar 2021

Pleurodesis Using Hypertonic Glucose Administration To Treat Post-Operative Air Leaks Following Lung Resection Surgery (Plug): Phase I Trial, Mehdi Qiabi

Electronic Thesis and Dissertation Repository

Introduction: Pulmonary air leaks from unhealed lung tissue are one of the most common complications after lung surgery. This adverse event leads to a delay in chest tube removal, prolonged pain, increased infections, prolonged hospital stay, and increased costs to the health care system. Objective: To define the most appropriate safe dose of dextrose 50% (D50) to seal air leaks in patients that have undergone lung resection surgery. Primary outcome was the occurrence of any adverse event. Methods: Prospective, single-arm, single-center, rule-based escalation traditional 3+3 design phase I trial where patients with an active air leak on postoperative day ...


"It's Certainly Someone's Job": The Roles Of Health Care Providers In Homelessness Prevention, Kayla May Mar 2021

"It's Certainly Someone's Job": The Roles Of Health Care Providers In Homelessness Prevention, Kayla May

Electronic Thesis and Dissertation Repository

Comprehensive strategies to end all homelessness must include prevention-focused approaches in addition to the provision of emergency services and responsive housing programs. This qualitative descriptive study examines nurse practitioners’ and physicians’ perceptions of their roles in homelessness prevention and their current involvement in prevention-oriented activities. Data from interviews with health care providers was analyzed using a blended inductive and deductive approach, guided by a Framework for Homelessness Prevention and findings from a document analysis. The results highlighted health care providers’ conceptualizations of poverty, housing instability, and associated risk factors and found that providers consider information about patients’ social and economic ...


Effects Of Branched-Chain Amino Acid Supplementation On Exercise Induced Muscle Damage And Delayed Onset Of Muscle Soreness After A Bout Of Eccentric Exercise, Crystal Lee Mar 2021

Effects Of Branched-Chain Amino Acid Supplementation On Exercise Induced Muscle Damage And Delayed Onset Of Muscle Soreness After A Bout Of Eccentric Exercise, Crystal Lee

Electronic Thesis and Dissertation Repository

Branched-chain amino acids (BCAA) have the potential to reduce both exercise-induced muscle damage (EIMD) and delayed onset of muscle soreness (DOMS) after a bout of eccentric contractions (ECC). The purpose of this study was to determine the effects of BCAA supplementation for 12 days prior to and for an additional 7 days following a bout of ECC on EIMD and DOMS. Sixteen women with no prior experience with strength training were assigned randomly to a BCAA group or a placebo group. Only four participants completed the trial due to COVID-19 (another completed 72h of recovery and was included). Participants supplemented ...


Exploring The Mental Health Experiences Of African, Caribbean, And Black Youth In London, Ontario, Lily Yosieph Mar 2021

Exploring The Mental Health Experiences Of African, Caribbean, And Black Youth In London, Ontario, Lily Yosieph

Electronic Thesis and Dissertation Repository

This qualitative study explores the mental health experiences of African, Caribbean, and Black (ACB) youth in London, Ontario, investigating how the factors of race, gender, culture, and place have shaped their perceptions and experiences of mental health. The data collection and analysis were conducted using a phenomenological approach and a critical lens informed by feminist, intersectionality, and critical race theories. These data illuminate the ways in which these young people’s attitudes toward mental health and help-seeking strategies are impacted by broader social constructs and community expectations, which they navigate and often resist in their everyday lives. Their insights can ...


Association Between Air Pollution And Incidence Of Dementia: A Systematic Review And Meta-Analysis Of Cohort Studies, Ehsan Abolhasani Feb 2021

Association Between Air Pollution And Incidence Of Dementia: A Systematic Review And Meta-Analysis Of Cohort Studies, Ehsan Abolhasani

Electronic Thesis and Dissertation Repository

Objective. To estimate the risk of dementia in association with exposure to air pollutants.

Methods. Six databases were searched. Cohort studies that reported the hazard ratio (HR) of dementia in association with exposure to air pollutants in adults > 40y were included. For all meta-analyses, the random-effects model was used.

Results. A total of 16 and 13 studies were included in the systematic review and the meta-analysis, respectively. Risk of dementia increased by 4% per 1μg/m3 increase in fine particulate matter level (HR, 1.04; 95%CI, [1.02, 1.06]), which was statistically significant. The risk of dementia ...


The Relation Of Auditory Temporal Processing To Language Development And Other Cognitive Processes: Methodological And Conceptual Considerations, Rachael E. Smyth Feb 2021

The Relation Of Auditory Temporal Processing To Language Development And Other Cognitive Processes: Methodological And Conceptual Considerations, Rachael E. Smyth

Electronic Thesis and Dissertation Repository

Separate lines of research have demonstrated relations between auditory temporal processing and language ability and between information processing speed and intelligence. Because these processes have rarely been studied in the same sample, it is unclear how auditory temporal processing and information processing speed may operate together and how they may relate to cognitive functions including language. The overarching aim of this dissertation was to integrate these lines of research to better understand whether auditory temporal processing has a unique relation with language, or whether it relates more broadly to language and other cognitive functions as a part of global information ...


A Critical Review And Finite Element Study Of Structural Relaxation In Veneered 3y-Tzp Dental Structures, Prashant S. Shelar Feb 2021

A Critical Review And Finite Element Study Of Structural Relaxation In Veneered 3y-Tzp Dental Structures, Prashant S. Shelar

Electronic Thesis and Dissertation Repository

Yttria stabilized Tetragonal Zirconia Polycrystal (3Y-TZP) materials veneered with porcelain are preferred for clinical practice due to their bio-functionality, biocompatibility, and affordability. However, these materials are often subjected to premature clinical failures due to combination of subsurface flaws and tensile stresses within porcelains. This work focuses on performing a critical literature review and evaluating veneer characteristics, i.e. structural relaxation, to form a suitable explanation for the development of subsurface stresses. User material subroutines, UEXPAN and UTRS are developed, validated and integrated in ABAQUS finite element solver. With the use of validated models, it is shown that faster cooling rates ...


Evaluating Anesthetic Protocols For Non-Human Primate Functional Neuroimaging, Megha Verma Feb 2021

Evaluating Anesthetic Protocols For Non-Human Primate Functional Neuroimaging, Megha Verma

Electronic Thesis and Dissertation Repository

Functional magnetic resonance imaging (fMRI) is a non-invasive technique that can be used to measure a proxy of neural activity in vivo with high spatial specificity. One subject can be followed for a long period of time to assess changes in functional brain organization. However, fMRI is extremely sensitive to motion. The challenges of training non-human primates to reduce motion in an MRI scanner motivate the study of anesthesia which is commonly used to substitute for this training. In this thesis, I compare three different commonly used anesthetic protocols: isoflurane, propofol-fentanyl in combination, and fentanyl alone, to test which of ...


The Experiences Of Iraqi Refugees In Canada: A Life History Study Of War And Resilience In The Aftermath Of Migration, Nada Nessan Feb 2021

The Experiences Of Iraqi Refugees In Canada: A Life History Study Of War And Resilience In The Aftermath Of Migration, Nada Nessan

Electronic Thesis and Dissertation Repository

This thesis reports on a life history narrative on the experiences of Iraqi refugees who resettled in Canada after living through war. The aim of this study is to help change the narrow perspectives on the mental health of war affected populations to a broader perception shaped by cultural and social aspects and to inform the development of meaningful and cultural relevant programs and policies with a particular attention to the concept of resilience.

The first part of the study presents the chronological narratives, or profiles. of eight participants. The second part of the study is a thematic discussion of ...


Speech-Language Pathology Interventions And Ingredients That Support Social Communication And Language Of Preschoolers With Autism, Amanda Binns Feb 2021

Speech-Language Pathology Interventions And Ingredients That Support Social Communication And Language Of Preschoolers With Autism, Amanda Binns

Electronic Thesis and Dissertation Repository

One of the best predictors of long-term outcomes for autistic children is development of language and social communication skills. Therefore, it’s not surprising that speech and language therapy is one of the most frequently accessed interventions for children with suspected or diagnosed autism. From a public health and family well-being perspective, identifying effective social communication interventions and better understanding the specific components that contribute to their effectiveness is critical. However, there is a lack of clarity about the most effective interventions. This dissertation addressed this important topic through three studies.

Study 1 examined the literature on interventions provided by ...


Surgical Residency Workload, Perceptions And Educational Value: Implications For Competency- Based Medical Education, Eric Walser Feb 2021

Surgical Residency Workload, Perceptions And Educational Value: Implications For Competency- Based Medical Education, Eric Walser

Electronic Thesis and Dissertation Repository

Introduction: Surgical training has transitioned to competency-based medical education. There is incomplete understanding of current resident workload and how workload is perceived by trainees and faculty.

Methods: A prospective time-motion study was conducted in a Canadian general surgery training program. A web-based survey was used to compare observational data with faculty and learner perceptions of actual and ideal resident workloads and the educational value of workload components.

Results: 54 clinical periods were assessed (662.8 hours, 6375 individual events). 39.7% of time was spent on direct patient care, 33.2% on indirect patient care and 7.5% on education ...


Debt And Stress Amongst Orthodontic Residents, Timothy Renison Feb 2021

Debt And Stress Amongst Orthodontic Residents, Timothy Renison

Electronic Thesis and Dissertation Repository

Background: The cost of education to become an orthodontist has increased significantly over recent years which has led to an increase in debt of graduating orthodontists.

Aim: This paper aims to assess whether debt amongst orthodontic residents in North America is associated with their stress levels, attitudes towards debt, financial literacy and mathematics anxiety.

Materials and Methods: Web-based software was used to fabricate a questionnaire, based on previously validated scales, in which respondents were asked questions regarding their debt levels, stress levels, attitudes towards debt, financial literacy and math anxiety.

Results: A total of 101 orthodontic residents completed the online ...


In Vitro Analyses Of The Contributions Of The Hip Capsule To Joint Biomechanics, Emma Donnelly Jan 2021

In Vitro Analyses Of The Contributions Of The Hip Capsule To Joint Biomechanics, Emma Donnelly

Electronic Thesis and Dissertation Repository

Optimal management of the hip capsule during arthroscopic surgery has not been established. The impact of incisions made to the capsule during minimally invasive procedures on joint biomechanics, and whether repair provides any benefit, continue to be debated. The effectiveness of capsular repair to restore native kinematics may be insufficient. Therefore, a better understanding of joint behavior during various capsule conditions is needed. A new robotic system was used to analyze the effect of progressive capsulotomy incision and repairs on the behavior of a normal hip within range of motion (ROM) limits with respect to the intact joint. Complete repairs ...


Health Care Initiative To Evaluate The Impact Of A Nurse Practitioner Led Community Wound Care Service On Emergency Department Utilization, Sherry Morrell Jan 2021

Health Care Initiative To Evaluate The Impact Of A Nurse Practitioner Led Community Wound Care Service On Emergency Department Utilization, Sherry Morrell

Electronic Thesis and Dissertation Repository

Nurse Practitioners (NP) diagnose and treat wounds and wound-related conditions based on their advanced scope of practice. An NP with graduate-level wound care education (NP(W)) gains additional knowledge and clinical experience to provide comprehensive wound care.

This research aimed to explore community patients’ access to wound care in Southwestern Ontario (Canada). A quality improvement project was initiated utilizing stakeholder feedback to develop and implement a 12-week pilot NP(W)-Led community-based wound care service; the NP(W) wound care practices, clinical outcomes, and adverse events were described. One hundred twelve participants attended the service over 117 visits. The NP ...


The Role Of Gsk3 Alpha And Beta In Embryonic Craniofacial Development, Harman Jassar Jan 2021

The Role Of Gsk3 Alpha And Beta In Embryonic Craniofacial Development, Harman Jassar

Electronic Thesis and Dissertation Repository

Background: The GSK-3 genes (Gsk3a and Gsk3b) have been known to affect many cellular processes and signaling pathways some of which are implicated in the growth and development of the craniofacial skeleton.

Aim: The purpose of this study was to assess the effect of chondrocyte-specific deletion of Gsk3a and Gsk3b on the size of the mandible and craniofacial skeleton in embryonic mice.

Materials & Methods: Mice were bred to generate cartilage-specific Gsk3a and Gsk3b KO mice. On embryonic day 18.5 (E18.5) the offspring were gathered by caesarian section. Whole mount skeletal staining was completed on the specimens using Alcian ...


Exploring Methods For Improving Baseplate Fixation In Reverse Total Shoulder Arthroplasty, Sejla Abdic Jan 2021

Exploring Methods For Improving Baseplate Fixation In Reverse Total Shoulder Arthroplasty, Sejla Abdic

Electronic Thesis and Dissertation Repository

Improving the success of modern reverse shoulder replacements is dependent on optimal initial baseplate fixation. A cadaveric biomechanical investigation examined how peripheral screw position and orientation affect baseplate fixation in normal glenoids. The results show no statistically significant difference between screw position (p=.60) or orientation (p=.20) regarding baseplate micromotion in the non-eroded glenoid. In a subsequent study to determine best management in pathologic baseplate fixation, a computer-model was employed to quantify the erosion in the E2 type glenoid. In the E2 type glenoid, erosion was found to be oriented postero-superiorly and covering an average of 66% of the ...


Perspectives Of Canadian University Coaches On Integrating Sport Psychology And Mental Performance Consultants In Varsity Programs, Federico Cisneros Sánchez Dec 2020

Perspectives Of Canadian University Coaches On Integrating Sport Psychology And Mental Performance Consultants In Varsity Programs, Federico Cisneros Sánchez

Electronic Thesis and Dissertation Repository

Recently, sport psychology has become a more popular resource for athletes and coaches when looking to increase performance. It is unknown how many Canadian universities utilize sport psychology services in their athletic programs. Semi-structured interviews were conducted with coaches of Canadian university varsity teams to learn about their opinions on sport psychology and mental performance consultants (MPCs). The research was approached from a pragmatic perspective. Results showed that MPCs are important to enhance performance and provide mental health resources. MPCs provide athletes with personal and leadership development, mental skills training, and mental health support. MPCs can also be a resource ...


The Effect Of Pigmentation On Latex And Non-Latex Orthodontic Elastics, Dustin Wilson Dec 2020

The Effect Of Pigmentation On Latex And Non-Latex Orthodontic Elastics, Dustin Wilson

Electronic Thesis and Dissertation Repository

Background: Intraoral Elastics have been widely used in Orthodontics for well over 100 years. Changes in material composition, manufacturing and addition of color to elastics has shown to effect force levels over time.

Aim: The purpose of the study was to determine the effect of pigmentation on force levels and their degradation over time in both Latex and Non-Latex orthodontic intraoral elastics.

Materials & Methods: Groups consisted of elastics in Latex from American Orthodontics in both natural and four different colors, American Orthodontics Non-Latex in natural, Ormco Latex in both natural and four different colors, Auradonics Latex in both natural and ...


Population-Based Studies On Medications And Fall-Related Injury In Older Adults, Yu Ming Dec 2020

Population-Based Studies On Medications And Fall-Related Injury In Older Adults, Yu Ming

Electronic Thesis and Dissertation Repository

Background: Fall-related injuries in older adults result in serious consequences to individuals and health care system, especially with the increasing aging population. The purpose of this study was to (1) describe medication prescription patterns within one year prior to fall-related injuries; (2) identify medication classes prescribed within 30 days prior to the injury that were associated to fall-related injury; and (3) examine the association between fall-related injuries and continuous use or new initiation of most commonly prescribed medications.

Methods: Studies used administrative health care data in Ontario. Study 1 described the frequency of medications prescribed to older adults within one ...


Detection And Quantification Of Cells Using Magnetic Particle Imaging And Magnetic Microspheres, Kierstin P. Melo Dec 2020

Detection And Quantification Of Cells Using Magnetic Particle Imaging And Magnetic Microspheres, Kierstin P. Melo

Electronic Thesis and Dissertation Repository

Magnetic particle imaging (MPI) is an emerging imaging modality that specifically detects superparamagnetic iron oxide nanoparticles (SPIOs). Our lab has shown that cell tracking with magnetic resonance imaging (MRI) has very high sensitivity, but low specificity and quantification of iron labeled cells is difficult. MPI cell tracking could overcome these limitations. A MomentumTM MPI system was installed at Robarts in August 2019 and this is the first project to be completed using MPI. In Chapter 2 a series of in vitro experiments are reported which tested the repeatability and reproducibility of imaging SPIO labeled cell samples. There are no ...


Improving Hydrid Pet/Mri Cardiovascular Imaging With Improved Hardware Design And Attenuation Correction Coefficient, Adam Helmy Farag Dec 2020

Improving Hydrid Pet/Mri Cardiovascular Imaging With Improved Hardware Design And Attenuation Correction Coefficient, Adam Helmy Farag

Electronic Thesis and Dissertation Repository

According to the World Health Organization (WHO) report in 2019, cardiovascular diseases (CVD) cause 52% of all illness-related deaths globally and are considered to be the second most common cause of death in Canada. CVD is also estimated to cost the Canadian economy about $21.2 billion in direct and indirect costs. With these figures, it is vital to develop the most effective and accurate methods and tools to diagnose accurately CVD and their causes. One of the promising tools for accurate diagnostic and therapeutic of CVD is the integrated Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) PET ...


Evidence Of An Antigen Presenting Cell Phenotype In Granular Cell Tumours, Benjamin J W A Rogala Dec 2020

Evidence Of An Antigen Presenting Cell Phenotype In Granular Cell Tumours, Benjamin J W A Rogala

Electronic Thesis and Dissertation Repository

Granular Cell Tumours (GCTs) are rare subepithelial lesions that are believed to develop from Schwann cells and are characterized by large polygonal cells with abundant lysosomes. Pilot studies from our laboratory showing unexpected HLA-DR immunoreactivity in GCTs lead us to hypothesize that GCTs have an antigen presenting cell (APC) phenotype.

To test our hypothesis, we assessed immunoreactivity of GCT lesions to APC phenotype markers, including CD68, HLA-DR, CD163, CD40 and CD11c. In addition, we assessed markers of neural crest cell (NCC) origin S100, SOX10, NSE and GAP43. Samples subjected to these studies included 23 cases of GCTs and 10 cases ...