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Full-Text Articles in Medicine and Health Sciences

Understanding The Role Of Social Identity/Position In Access To Primary Care Providers: An Intersectionality Approach Using Multilevel Analysis Of Individual Heterogeneity And Discriminatory Accuracy (Maihda), Jennifer W. He Jun 2022

Understanding The Role Of Social Identity/Position In Access To Primary Care Providers: An Intersectionality Approach Using Multilevel Analysis Of Individual Heterogeneity And Discriminatory Accuracy (Maihda), Jennifer W. He

Electronic Thesis and Dissertation Repository

Primary care (PC) in Canada is concerned with addressing Canadian health needs, especially the most vulnerable. The roles of social identities and positions in having a PC provider has been treated primarily as independent and additive, instead of interdependent and intersecting. A quantitative intersectionality approach using multilevel analysis of individual heterogeneity and discriminatory accuracy examined whether respondents to the Canadian Community Health Survey (2015-2019) had a PC provider based on membership in intersectional strata (constructed using gender, age, immigration status, race, and income). This study found that not all between-stratum variance in the outcome could be explained by additive effects ...


Language-Based Strategies That Support Person-Centered Communication In Formal Home Care Interactions With Persons Living With Dementia, Reanne G. Mundadan Jun 2022

Language-Based Strategies That Support Person-Centered Communication In Formal Home Care Interactions With Persons Living With Dementia, Reanne G. Mundadan

Electronic Thesis and Dissertation Repository

Background. Several studies recommend language-based strategies for communication with persons living with dementia. Language-based strategies improve coherence, clarity, reciprocity, and continuity of interactions. Person-centered communication (PCC) strategies are the gold standard, including facilitation, recognition, validation, and negotiation. Only one study has examined the overlap between language-based strategies and PCC in long-term care. Little is known about which language-based strategies support PCC in home care. Accordingly, this study investigated the overlap between language-based strategies and PCC in home care interactions. Method. Conversation analysis of 30 audio-recorded routine care interactions between home care workers and persons living with dementia was conducted. The ...


Evaluating The Utility Of S100a7 In Identifying Oral Dysplastic Lesions That Will Progress To Oral Squamous Cell Carcinoma, Jeff Soparlo May 2022

Evaluating The Utility Of S100a7 In Identifying Oral Dysplastic Lesions That Will Progress To Oral Squamous Cell Carcinoma, Jeff Soparlo

Electronic Thesis and Dissertation Repository

Title: Evaluating the utility of S100A7 in identifying oral dysplastic lesions that will progress to oral squamous cell carcinoma Introduction: Recently, S100A7 has been shown to be a potential useful marker for identifying oral lesions at risk of transformation from dysplasia to squamous cell carcinoma. Our hypothesis is that high S100A7 protein expression predicts the transformation of oral epithelial dysplasia to malignancy. The objective of our study is to semi-quantitatively evaluate the level of S100A7 expression in dysplastic lesions which have transformed into oral squamous cell carcinoma using immunohistochemistry, and correlate these results with other methods of analysis including the ...


Lived Experience Of Having Difficult Conversations Among Care Partners Of Individuals With Parkinson's: An Occupational Science Perspective, Helen A. Reid May 2022

Lived Experience Of Having Difficult Conversations Among Care Partners Of Individuals With Parkinson's: An Occupational Science Perspective, Helen A. Reid

Electronic Thesis and Dissertation Repository

Difficult conversations, which can be challenging co-occupations, play an important role in the lives of care partners of individuals living with Parkinson’s disease. In our first study for this integrated-article thesis, we used a critical interpretive synthesis to explore how informal caregiving had been conceptualized in occupation-focused research. We found that an occupational perspective illuminated otherwise overlooked aspects of caregiving. In our second study, we used an occupational science lens to explore how seven care partners of individuals with PD experienced having difficult conversations within the caring role. We conducted two rounds of in-depth semi-structured interviews and used an ...


Hand Swelling After Hand And Wrist Surgery: An Evaluation Of Its Effects And Assessment Of Feasibility Of A Double Blinded, Randomized Controlled, Pilot Study: Tranexamic Acid In Hand And Wrist Surgery (Thaw) Study, Kendrick Au May 2022

Hand Swelling After Hand And Wrist Surgery: An Evaluation Of Its Effects And Assessment Of Feasibility Of A Double Blinded, Randomized Controlled, Pilot Study: Tranexamic Acid In Hand And Wrist Surgery (Thaw) Study, Kendrick Au

Electronic Thesis and Dissertation Repository

Hand and wrist edema after surgery is a common side effect. It is often first identified visually by the treating physician or therapist. Once recognized, conventional edema treatment is typically partially successful. However, there are a subset of patients that continue to have significant postoperative hand and wrist edema following surgery despite these therapies. This can be devastating to the patient and may lead to pain, stiffness and a reduced quality of life. Surprisingly, there is limited research providing objective reference values for hand and wrist edema acutely after surgery. The first objective of this thesis was to objectively assess ...


Radiographic Predictors Of Functional Outcome In Degenerative Lumbar Spondylolisthesis Surgery, Patrick Thornley Apr 2022

Radiographic Predictors Of Functional Outcome In Degenerative Lumbar Spondylolisthesis Surgery, Patrick Thornley

Electronic Thesis and Dissertation Repository

Objective: To confirm the importance of sagittal spinal alignment on functional outcome with degenerative lumbar spondylolisthesis (DLS) surgery and to identify the radiographic parameters that predict functional outcomes after DLS surgery.

Methods: Retrospective analysis of the prospectively collected functional and radiographic outcomes of the Canadian Spine Outcomes and Research Network DLS database. All patients underwent either decompression, posterolateral fusion or interbody fusion surgery with a minimum of one-year postoperative follow-up.

Results: Most patients improve or remain unchanged in their sagittal spinal alignment regardless of surgery type with fusion procedures not experiencing statistically significantly improved alignment changes to decompression alone. By ...


Seeing Thro The Musical Eye: Santo Daime, Fuke-Shū, 1960s Psychedelia, And The Antipodes Of Musical Experience, Forest Anthony-Muran Apr 2022

Seeing Thro The Musical Eye: Santo Daime, Fuke-Shū, 1960s Psychedelia, And The Antipodes Of Musical Experience, Forest Anthony-Muran

Electronic Thesis and Dissertation Repository

This thesis investigates the relationships between altered states of consciousness and the musical experience in religious tradition and practice. A common accompaniment to religious worship and ceremony, music is often used as a way of attempting to capture something of the ineffable and to help bring about a mystical experience. In this thesis, I make use of three contrasting case studies – the Brazilian syncretic religion Santo Daime, the historical branch of Zen Buddhism Fuke-shū, and the psychedelic rock of 1960s counterculture – to paint a portrait of the variety of ways that music has been used in different musical traditions to ...


Practice-Based Research In Speech-Language Pathology, Meghan Vollebregt Apr 2022

Practice-Based Research In Speech-Language Pathology, Meghan Vollebregt

Electronic Thesis and Dissertation Repository

Practice-based research is an active and collaborative approach to clinical research that minimizes the research-practice gap. Practice-based research involves collecting data in practice to answer questions that arise from clinical practice. The findings from this research then inform future practices. Though over the past two decades there has been a significant increase in knowledge translation activities, especially the use of collaborative partnerships, the integration of these practices in speech-language pathology is in its infancy. In this thesis, I investigate the role of practice-based research in speech-language pathology. In Chapter 2, I first examine the current role of practice-based research in ...


A Comparison Of Voice Amplifiers And Personal Communication Systems In Individuals With Hypophonia: An Exploration Of Communicative Participation, Jessi-Rae A. Schroeder Apr 2022

A Comparison Of Voice Amplifiers And Personal Communication Systems In Individuals With Hypophonia: An Exploration Of Communicative Participation, Jessi-Rae A. Schroeder

Electronic Thesis and Dissertation Repository

Hypophonia is one of the most prevalent speech impairments in hypokinetic dysarthria. Unfortunately, behavioral interventions for hypophonia often fail to generalize beyond the clinic. An alternative approach to management is the use of speech amplification devices. This study evaluated how 17 individuals with hypophonia (HP) and their primary communication partners (PCPs) rated communicative participation across three, one-week device trial periods at home. Amplification devices included: a wired belt pack amplifier, wireless stationary amplifier, and personal FM system. Patient-reported outcome measures included the CES, VAPP and PIADS. Results indicated HPs rated participation higher following device use in comparison no device. Further ...


Identification Of Dna Methylation Episignatures For Classification And Phenotype/Genotype Correlation In Mendelian Neurodevelopmental Disorders, John Reilly Apr 2022

Identification Of Dna Methylation Episignatures For Classification And Phenotype/Genotype Correlation In Mendelian Neurodevelopmental Disorders, John Reilly

Electronic Thesis and Dissertation Repository

ABSTRACT: Diagnosis for neurodevelopmental disorders poses numerous challenges, related to the lack of specific findings and limited understanding of clinical impact of the majority of genetic variation. Epigenomics mechanisms involve chemical modifications in DNA that involve a range of cellular mechanisms. DNA methylation is an epigenetic mechanism involving addition and removal of methyl groups to cytosine residues. These methylation signals form episignatures; patterns of methylation that can be used as biomarkers capable of differentiating neurodevelopmental disorders. EpiSigns have enabled molecular diagnosis of a number of genetic conditions, classification of variants of unknown significance, and provided insights into the pathophysiology of ...


Host Organizations' Perspectives Of Partnered Global Study-Abroad Programs, Jessica C. Pop Apr 2022

Host Organizations' Perspectives Of Partnered Global Study-Abroad Programs, Jessica C. Pop

Electronic Thesis and Dissertation Repository

Background: The relationships between sending and host partners in nursing study-abroad programs are crucial to the success and sustainability of these programs. Yet, there has been a paucity of research focused on the global partnerships between sending and host organizations. Most research about study-abroad programs has primarily focused on Global North sending organizations’ perspectives on the educational, social, and career benefits to Global North students with few studies highlighting the perspectives of host organizations from the Global South.

Aim: To explore Global South host organizations’ perspectives about global partnered nursing study-abroad programs.

Research Design: This research study was guided by ...


Head’S Up! Examining The Relationship Between Field Of View And Head Position In Ice Hockey Players, Kristine E. Walker Apr 2022

Head’S Up! Examining The Relationship Between Field Of View And Head Position In Ice Hockey Players, Kristine E. Walker

Electronic Thesis and Dissertation Repository

Ice hockey is a dynamic, fast-paced game where players need to be aware of multiple factors, devoting appropriate attention to varying salient aspects to enhance performance. The term “keep your head up” is ubiquitous encouragement because if players do not, their visual field (what they can see) is compromised, performance (what they can do) decreases, and likelihood of injury increases. Head-down behaviour is problematic and is observed at all skill levels. Head position (HP) behaviour has not been quantified objectively in any sport. Through collaboration with an NHL player development coach, their practice-based knowledge and tacit experience informed the direction ...


The Effect Of Modifications To Intermaxillary Orthodontic Elastics On Force Levels And Degradation Over Time, Steven Dent Mar 2022

The Effect Of Modifications To Intermaxillary Orthodontic Elastics On Force Levels And Degradation Over Time, Steven Dent

Electronic Thesis and Dissertation Repository

Introduction: Orthodontic elastics are frequently used in orthodontic treatment but there is little research into how to modify their prescription to improve their performance. The aim of this study was to evaluate potential wear modifications to a standard Class II intermaxillary elastic prescription on force levels and force degradation over time.

Methods: For this in vitro study, Ormco (OR) and American Orthodontic (AO) latex elastics had five modifications made to a standard 1/4”/4.5oz control elastic (Group 1). These included an increase of force level by one unit to 6 or 6.5oz (Group 2); a decrease in ...


The Effect Of Interprofessional Conflict Resolution On Interprofessional Collaborative Practice Among Health Care Provider Teams In Hospitals, Sibylle Ugirase Mar 2022

The Effect Of Interprofessional Conflict Resolution On Interprofessional Collaborative Practice Among Health Care Provider Teams In Hospitals, Sibylle Ugirase

Electronic Thesis and Dissertation Repository

Client needs and their complexities have increased, challenging multiple professionals to work together within health systems to reach better patient outcomes. Addressing this challenge requires interprofessional collaboration, which, while essential, may also breed conflict given that individuals from various health care disciplines each bring their unique perspectives into teamwork. While some degree of disagreement is expected, team members must be able to resolve conflicts to ensure effective patient care. However, limited information was available that described and clearly defined interprofessional conflict resolution as a concept.

The aim of this study was threefold. This study began with a concept analysis of ...


Navigating, Negotiating, And Narrating: Re-Envisioning Patient-Centered Chronic Illness Care, Wilma J. Koopman Mar 2022

Navigating, Negotiating, And Narrating: Re-Envisioning Patient-Centered Chronic Illness Care, Wilma J. Koopman

Electronic Thesis and Dissertation Repository

Patient-centered care (PCC) is ubiquitous in how we think about patient-practitioner encounters. But such a taken-for granted stance may unknowingly obscure how conversations actually unfold in real life. The purpose of this work is to unravel the disconnect between how patient-centered care is talked about and how it is implemented in the real world. The overarching research question that framed this study was: What are the influences that shape the unfolding of the conversations that occur at chronic illness health encounters and how does this unfolding influence the learning and execution of PCC? The aim of this research was to ...


Cost-Effective Non-Destructive Testing Of Biomedical Components Fabricated Using Additive Manufacturing, Santiago Fabian Cobos Mar 2022

Cost-Effective Non-Destructive Testing Of Biomedical Components Fabricated Using Additive Manufacturing, Santiago Fabian Cobos

Electronic Thesis and Dissertation Repository

Biocompatible titanium-alloys can be used to fabricate patient-specific medical components using additive manufacturing (AM). These novel components have the potential to improve clinical outcomes in various medical scenarios. However, AM introduces stability and repeatability concerns, which are potential roadblocks for its widespread use in the medical sector. Micro-CT imaging for non-destructive testing (NDT) is an effective solution for post-manufacturing quality control of these components. Unfortunately, current micro-CT NDT scanners require expensive infrastructure and hardware, which translates into prohibitively expensive routine NDT. Furthermore, the limited dynamic-range of these scanners can cause severe image artifacts that may compromise the diagnostic value of ...


Examining The Impact Of Financial Incentive Removal On Physical Activity: A Quasi-Experimental Study Of 584,760 Mobile Health Application Users, Sean Kevin Spilsbury Mar 2022

Examining The Impact Of Financial Incentive Removal On Physical Activity: A Quasi-Experimental Study Of 584,760 Mobile Health Application Users, Sean Kevin Spilsbury

Electronic Thesis and Dissertation Repository

BACKGROUND: Government interest in using financial incentives (FIs) to stimulate physical activity (PA) is increasing. The cost of longer-term incentive interventions may be prohibitive, however. PURPOSE: To examine the impact of FI withdrawal on PA. METHODS: A 25-week retrospective pre-post quasi-experimental study was conducted with users of a FI-based mHealth app. Users from three Canadian provinces were included. Daily FI were removed in Ontario (ON; intervention) but not British Columbia (BC) and Newfoundland and Labrador (NL; control). Simple linear regression models were used to examine weekly mean daily step count after FI withdrawal. RESULTS: The total sample included 584,760 ...


The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi Feb 2022

The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi

Electronic Thesis and Dissertation Repository

Modic changes (MCs), defined as bone marrow lesions adjacent to the vertebral endplate seen on MRI, have been associated with back pain. There are different types of MCs, with different histopathological correlates. This community-based study sample comprised 110 men from the Twin Spine Study, with baseline, 5-year, and 15-year follow-up MRIs. Following training and reliability testing, 1320 endplates (T12-S1) were evaluated for MC presence, type, and dimensions at each time point. Results demonstrated that Type 2 Modic Changes (MC2) were the most common type, with approximately half located at the two lowest disc levels. However, Type 1 Modic Changes (MC1 ...


Organizational Implementation Of Trauma And Violence Informed Care, Tanaz Javan Feb 2022

Organizational Implementation Of Trauma And Violence Informed Care, Tanaz Javan

Electronic Thesis and Dissertation Repository

For the past several decades, social and health services have increased their efforts to enhance service delivery and close the ‘science-to-service’ (or ‘evidence-to-practice’) gap by implementing effective interventions. At the same time, there has been growing recognition of the prevalence of trauma and violence in the lives of those served and those providing care and the impact of these experiences on service needs and interactions. This study explored the implementation of trauma- and violence-informed care (TVIC), a complex intervention focused on providing safety and choice for service users in the context of their life experiences and conditions, exploring factors that ...


Emerging Adult Perspectives On Marijuana Usage And Social Isolation During Covid-19, Avery Kiana Wong Feb 2022

Emerging Adult Perspectives On Marijuana Usage And Social Isolation During Covid-19, Avery Kiana Wong

Electronic Thesis and Dissertation Repository

Individuals struggling with emotional distress are twice as likely to use marijuana routinely. Young adults, ages 18 to 24, continue to be at increased risk for accidents, injuries, and poor cognitive functioning when using cannabis regularly, compared to those 24 and older. In addition, studies have shown that increased social isolation further increases the risk of marijuana use in young adults. Previous literature also demonstrated that marijuana is currently being used as a method of treatment for emotional distress. Much of the research conducted to date has focused on the collection of checklist data that has looked at the presence ...


Implementing Health Impact Assessment As A Required Component Of Government Policymaking: A Multi-Level Exploration Of The Determinants Of Healthy Public Policy, Stephanie A. Simpson Feb 2022

Implementing Health Impact Assessment As A Required Component Of Government Policymaking: A Multi-Level Exploration Of The Determinants Of Healthy Public Policy, Stephanie A. Simpson

Electronic Thesis and Dissertation Repository

It is widely understood that the public policies of ‘non-health’ government sectors have greater impacts on population health than those of the traditional healthcare realm. Health Impact Assessment (HIA) is a decision support tool that identifies and promotes the health benefits of policies while also mitigating their unintended negative consequences. Despite numerous calls to do so, the Ontario government has yet to implement HIA as a required component of policy development. This dissertation therefore sought to identify the contexts and factors that may both enable and impede HIA use at the sub-national (i.e., provincial, territorial, or state) government level ...


Exploring The Effects Of Spinal Cord Stimulation For Freezing Of Gait In Parkinsonian Patients, Olivia Samotus Feb 2022

Exploring The Effects Of Spinal Cord Stimulation For Freezing Of Gait In Parkinsonian Patients, Olivia Samotus

Electronic Thesis and Dissertation Repository

Dopaminergic replacement therapies (e.g. levodopa) provide limited to no response for axial motor symptoms including gait dysfunction and freezing of gait (FOG) in Parkinson’s disease (PD) and Richardson’s syndrome progressive supranuclear palsy (PSP-RS) patients. Dopaminergic-resistant FOG may be a sensorimotor processing issue that does not involve basal ganglia (nigrostriatal) impairment. Recent studies suggest that spinal cord stimulation (SCS) has positive yet variable effects for dopaminergic-resistant gait and FOG in parkinsonian patients. Further studies investigating the mechanism of SCS, optimal stimulation parameters, and longevity of effects for alleviating FOG are warranted. The hypothesis of the research described in ...


Connexin 43 Contributes To Phenotypic Variability Of The Mouse Skull, Elizabeth Jewlal Feb 2022

Connexin 43 Contributes To Phenotypic Variability Of The Mouse Skull, Elizabeth Jewlal

Electronic Thesis and Dissertation Repository

The purpose of this study was to determine whether connexin 43 (Cx43) contributes to craniofacial phenotypic variability. Skull shape and variation were compared within and among two heterozygous mutant mouse models (G60S/+ and I130T/+) that exhibit different levels of Cx43 channel function when compared to their wildtype counterparts (~80% and ~50% reduction in function, respectively). Results indicated mutants have significant differences in skull shape compared to wildtype littermates. Similar patterns of shape difference were found in both mutants. Increased skull shape variation and a disruption in the covariation of skull structures were observed in G60S/+ mutants only. These results show ...


Development Of An In Vitro Model Of Ischemia Reperfusion Injury In Kidney Transplantation, Ashley Jackson Feb 2022

Development Of An In Vitro Model Of Ischemia Reperfusion Injury In Kidney Transplantation, Ashley Jackson

Electronic Thesis and Dissertation Repository

Kidney transplantation remains the optimal treatment option for patients with end-stage renal disease. We aim to improve organ preservation during transplantation by reducing damage from ischemia reperfusion injury (IRI) using existing clinically approved drugs. In this study, we developed and characterized an in vitro model that mimics the conditions of IRI in kidney transplant as a tool to screen and study the therapeutic effect of drugs in the context of IRI. We recapitulated several key outcomes in IRI in our model, including the induction of hypoxia, cell death, increased expression of damage markers (NGAL, HMBG-1) and pro-inflammatory cytokines in a ...


Torque Expression Of Active And Passive Self-Ligating Orthodontic Brackets With Different Stainless Steel Wire Sizes, Jennifer L. Boogaards Jan 2022

Torque Expression Of Active And Passive Self-Ligating Orthodontic Brackets With Different Stainless Steel Wire Sizes, Jennifer L. Boogaards

Electronic Thesis and Dissertation Repository

This investigation aimed to compare engagement angles and torquing moments generated by stainless steel (SS) wires in three active self-ligating (ASL), one passive self-ligating (PSL), and a conventional twin orthodontic bracket system control. Brackets were tested in simulations of buccal and palatal root torque using four sizes of SS wires (16x22, 17x25, 19x25, 20x20 mil). A custom 3D printed testing apparatus was developed to measure torque. After initial engagement within bracket slots, torquing moments increased with progressive rotation of brackets around wires. In general, the PSL and conventionally ligated systems generated significantly larger torquing moments than ASL systems, especially with ...


Women’S Experiences Of Accessing Breastfeeding And Perinatal Health Support In The Context Of Intimate Partner Violence: An Interpretive Description Study, Samantha Larose Jan 2022

Women’S Experiences Of Accessing Breastfeeding And Perinatal Health Support In The Context Of Intimate Partner Violence: An Interpretive Description Study, Samantha Larose

Electronic Thesis and Dissertation Repository

Background: Women experiencing intimate partner violence are at a heightened risk of negative perinatal and breastfeeding outcomes. This study explored the experiences of accessing breastfeeding support for women who endorse a history of intimate partner violence. A study of five in-depth semi-structured interviews were completed at 12-weeks postpartum with breastfeeding mothers with a history of intimate partner violence. Findings: Women expressed difficulties in accessing a healthcare provider who had specialized skill in breastfeeding support. Trust in their healthcare provider, built through displays of compassion and competence, was important to mitigate obstacles experienced during care access for this population. Trauma-and-violence-informed care ...


The Genetics Of Pain: An Exploration Of Gene-By-Environment Interactions And Their Effects On Pain, Mohamad F. Fakhereddin Jan 2022

The Genetics Of Pain: An Exploration Of Gene-By-Environment Interactions And Their Effects On Pain, Mohamad F. Fakhereddin

Electronic Thesis and Dissertation Repository

The findings presented in this dissertation are part of the bigger SYMBIOME project which aims to use the biopsychosocial model of pain to develop a prognostic clinical phenotype for people that experience musculoskeletal (MSK) trauma. Chapter 2 presents an exploratory analysis to assess the relationships between genetic polymorphisms and pain severity and interference. Early childhood trauma was also explored as a moderator between genetic polymorphisms and pain outcomes. For pain severity, major allele carriers (A/A and G/A) of FKBP5 rs9394314 reported significantly higher scores than minor allele carriers (G/G). Further, major allele carriers who had at least ...


Approaches To Examining The Role Of Auditory Evoked Potentials In Early Language Development, Alyssa Janes Jan 2022

Approaches To Examining The Role Of Auditory Evoked Potentials In Early Language Development, Alyssa Janes

Electronic Thesis and Dissertation Repository

Previous research has suggested a relationship between auditory evoked potentials (AEPs) and spoken language proficiency, but their interactions during the earliest stages of development are not well understood. AEP-Age, an index that estimates the maturity of a child’s AEP relative to same-aged peers, has been effective in investigating this relationship in school-aged children, but has yet to be applied to younger populations. This thesis includes two Stage 1 Manuscripts (Registered Reports) for future studies to (a) assess the utility of AEP-Age to predict chronological age and language ability in 18-48-month-old children, and (b) investigate the relationship between AEP-Age and ...


Exploring Multimodal Cancer Cell Tracking Using Magnetic Particle Imaging And Akaluc Bli, Ryan J. Williams Dec 2021

Exploring Multimodal Cancer Cell Tracking Using Magnetic Particle Imaging And Akaluc Bli, Ryan J. Williams

Electronic Thesis and Dissertation Repository

Magnetic Particle Imaging (MPI), a novel imaging technology, offers hotspot visualization and quantification of superparamagnetic iron oxide (SPIO) labelled cells in vivo. Bioluminescence imaging (BLI), with the sensitive reporter Akaluc, can provide complementary information on cell viability and proliferation. Here, we combined MPI, and Akaluc BLI for a more holistic picture of cancer cell fate in mice. Breast cancer cells labelled with Akaluc and the SPIO Synomag-D, were injected into the mammary fat pad (MFP) of mice and imaged on BLI and MPI for 2-weeks. Over this period, BLI signal increased due to tumour progression, while MPI signal decreased due ...


Biomechanical Analysis Of Ligament Modelling Techniques And Femoral Component Malrotation Following Tka, Liam A. Montgomery Dec 2021

Biomechanical Analysis Of Ligament Modelling Techniques And Femoral Component Malrotation Following Tka, Liam A. Montgomery

Electronic Thesis and Dissertation Repository

Previous studies have demonstrated that satisfaction and revision rates following total knee arthroplasty (TKA) are lower than those of comparable surgeries such as total hip replacements. A leading cause for these revisions is joint instability which may be due to improper ligament balancing or poorly aligned surgical implants. One of the methods used to investigate biomechanical forces and kinematics is computational modelling of the post-operative TKA knee.

A unique knee model was used to investigate the biomechanical and kinematic effects of ligament model complexity, as well as the effects of simulating ligament wrapping versus ignoring ligament wrapping. We then used ...