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Full-Text Articles in Medicine and Health Sciences

Lugar Sagrado: A Sacred Place, Bennett E. Vogt May 2020

Lugar Sagrado: A Sacred Place, Bennett E. Vogt

Streams of Consciousness

The intent of publishing is to share my work of fiction about a young boy facing both his own and his mother’s mortality in the context of a chronic illness. The piece was originally created for a creative writing course, but was never published, and has been edited since into its current form.

Berlin Prize 2020 Third Place Winning Submission


Efforts To Improve Breast Cancer Screening In A Rural Primary Care Clinic, Michelle Voudrie, Simi Dhillon May 2020

Efforts To Improve Breast Cancer Screening In A Rural Primary Care Clinic, Michelle Voudrie, Simi Dhillon

Doctor of Nursing Practice Projects

Breast cancer is the second-leading cause of cancer-related deaths among women in the United States. The American College of Obstetricians and Gynecologists (ACOG) recommend women at average risk of breast cancer to begin screening mammography starting at age 40. Mammography has been recognized as the most substantial tool to detect breast cancer. However, many rural organizations have seen a decrease in mammography compliance rates. The goal of this project was to create an evaluation and follow-up protocol for women in a rural primary care clinic who meet the criteria for ACOG’s guidelines for breast cancer screening which promotes increased ...


How Can We Stop Cancer?, Joseph R. Current May 2020

How Can We Stop Cancer?, Joseph R. Current

The Review: A Journal of Undergraduate Student Research

Cancer is a disease that humans have been struggling to combat for centuries. It originates from the accumulation of several mutations over the life of a cell that causes it to evade cell death and multiply rapidly. It can affect any tissue in the body and can spread to other parts of the body through metastasis. Cancer comes in numerous shapes and sizes with different levels of aggression, growth speeds, and health risks. Many treatments for cancer exist today, three of the most popular being surgery, chemotherapy, and radiation therapy, which can be used in combinations with other treatments to ...


An Examination Of The Use Of Corticosteroids For Adverse Effects Related To Immunotherapy Treatment In Cancer Patients, Leanne Kilzer May 2020

An Examination Of The Use Of Corticosteroids For Adverse Effects Related To Immunotherapy Treatment In Cancer Patients, Leanne Kilzer

Nursing Capstones

No abstract provided.


The Management Of Cancer Pain: Should Interventional Therapies Be Approached As First-Line Treatment Along With Beginning An Opioid Regimen?, Sarah Holmes May 2020

The Management Of Cancer Pain: Should Interventional Therapies Be Approached As First-Line Treatment Along With Beginning An Opioid Regimen?, Sarah Holmes

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Cancer produces many symptoms, and pain is one of them. When a person is having pain due to cancer, many aspects of the person’s life may be altered or inhibited; for example, activities of daily living may be difficult to perform, their psychological state may be altered, their social lives may be changed, and their overall physical function may be affected in a way that the person may need to modify what they typically do in a normal day. The pain a person experiences depends on the type of cancer, how far the cancer has progressed, and the treatment ...


Paying It Forward: A Cancer Survivor And His Wife Share Their Reflections And Recommendations As A Patient And Caregiver, Justin Sandler Apr 2020

Paying It Forward: A Cancer Survivor And His Wife Share Their Reflections And Recommendations As A Patient And Caregiver, Justin Sandler

Patient Experience Journal

I grew up in the north suburbs of Chicago and had a relatively normal childhood but not necessarily an easy one. Shortly after graduating from Indiana University, I moved out west and have been working in the entertainment industry ever since. My life has been a beautiful and interesting adventure with twists and turns I could have never predicted.

In 2016 it seemed like everything was really coming together. I had been happily married to my wife and business partner Mary Lou Sandler since 2011, and we had been growing our photography/film production studio for as many years. I ...


Data Analysis Of A National Health And Nutrition Examination Survey (Nhanes) To Identify The Relationship Between Obesity And Cancer, Reyhaneh A. Yazdi, Ramona Stone Apr 2020

Data Analysis Of A National Health And Nutrition Examination Survey (Nhanes) To Identify The Relationship Between Obesity And Cancer, Reyhaneh A. Yazdi, Ramona Stone

Health Student Work

Introduction: Obesity and cancer independently are two important causes of death in the USA. A growing number of studies shows that these two chronic illnesses are related.

Objective: To examine the relationship of cancer and obesity using BMI and Waist Circumference (WC) as indicators using the National Health and Nutrition Examination Survey (NHANES) dataset.

Method: NHANES (2013-2014) dataset was used to obtain information on BMI, Waist Circumference (WC), and cancer (presence or absence) among the participants. The prevalence of obesity and cancer was tested with Pearson λ^2 test and the relationship of these two with education (5 levels) was ...


Exploring Occupational Disruption In Newly Diagnosed Individuals With Cancer With Minor (Dependent) Children, Riley S. Harrold Apr 2020

Exploring Occupational Disruption In Newly Diagnosed Individuals With Cancer With Minor (Dependent) Children, Riley S. Harrold

Student Capstone Projects

Background: According to the American Cancer Society (2019), there were more than 1.7 million new cases of cancer in 2019 alone. Individuals are being diagnosed at a young age with 22.4% of cases occurring in individuals 22-55 years old and whom are childrearing age (Shah et al., 2017). There are an estimated 2.85 million children under the age of 18 who are living with a parent who has cancer (Shah et al., 2017). Newly diagnosed individuals face changes in daily life, the threat of possible death, and fear of dying (Compas et al., 1994). Changes in shared ...


Spiritual And Religious Interventions For Medically High-Risk Adults: A Systematic Review, Nathanael J. Strissel Apr 2020

Spiritual And Religious Interventions For Medically High-Risk Adults: A Systematic Review, Nathanael J. Strissel

Senior Honors Theses

This systematic review is an update and expansion to the population and methods of a previous systematic review concerning spiritual and religious interventions for the well-being of terminally ill adults. After expanding the criteria to incorporate a more diverse population and including non-randomized experimental studies that contained relatively few concerns of bias, the results of the review are inconclusive due to insufficient data. The lack of usable data in the field highlights the ethical and theoretical issues with the use of experimental trials in analyzing the efficacy of spiritual and religious interventions. The development of spirituality in healthcare will remain ...


Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence Apr 2020

Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence

Honors Theses

Selinexor is currently being used in several clinical trials for cancer and has shown anti-cancer effects in combination with other chemotherapies. Clinical trials evaluating the use of selinexor in the treatment of triple negative breast cancer are limited, but in vitro studies show promising results in its ability to kill triple negative breast cancer cells. The mechanism by which this occurs, however, is not understood. The goal of this research was to determine the mechanism by which selinexor kills BT- 549 triple negative breast cancer cells.


Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles Apr 2020

Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles

Honors Theses

This study used gene expression analysis to explore the specific response to amodiaquine in HCT116 colorectal cancer cells. Real-time PCR revealed that 20 human stress and toxicity genes were upregulated by at least 3 fold in HCT116 colorectal cancer cells treated with AMQ. Of these 20 upregulated genes, 9 were found to be pro-apoptotic and 2 were DNA damage repair genes, which supports our original hypothesis that amodiaquine is inducing a stress response in these cells. These results are consistent with previous research done by Qiao et al. (2013), as DNA damage repair genes were among the genes upregulated in ...


Genetic Relationships And Therapeutic Options For Relapsed Acute Lymphoblastic Leukemia, Hailie Shertzer Apr 2020

Genetic Relationships And Therapeutic Options For Relapsed Acute Lymphoblastic Leukemia, Hailie Shertzer

Senior Honors Theses

Acute lymphoblastic leukemia (ALL) is the most common form of cancer among children and can be lethal to the adult population. Though 80% of patients with ALL reach complete remission after treatment, about 20% of those diagnosed fail to remain cancer-free. Genetic rearrangements are the hallmark of relapsed ALL, but the mechanism by which these rearrangements occur is still unclear. Recent research suggests these mutations may be detectable during initial diagnosis. If researchers are able to accurately assess the probability of relapse during diagnosis by analyzing the genome of the leukemic cells, the likelihood of administering effective therapy would increase ...


Abstracts From The 26th Annual Health Care Systems Research Network Conference, April 8–10, 2020 Apr 2020

Abstracts From The 26th Annual Health Care Systems Research Network Conference, April 8–10, 2020

Journal of Patient-Centered Research and Reviews

The Health Care Systems Research Network (HCSRN) is made up of community-based care delivery systems with a shared mission to improve health and health care through research. The network’s annual conference serves as a forum for attendees to disseminate study findings, stimulate collaborations, and share insights about conducting research in real-world care settings. Although this year’s live conference was cancelled to help slow the spread of COVID-19, the oral and poster abstracts accepted for presentation at HCSRN 2020 are published in this open access supplement to Volume 7, Issue 1 of the Journal of Patient-Centered Research and Reviews ...


A High Glucose Concentration Is Well Tolerated By Colorectal Adenocarcinoma And Melanoma Cells But Toxic To Normal Human Gingival Fibroblast: Results Of An In Vitro Investigation, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa Apr 2020

A High Glucose Concentration Is Well Tolerated By Colorectal Adenocarcinoma And Melanoma Cells But Toxic To Normal Human Gingival Fibroblast: Results Of An In Vitro Investigation, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Glucose is associated with weight gain, which increases the risk of cancer. There is insufficient information on the effects of high glucose concentrations on cell lines. This study evaluated the viability patterns of human cancer and normal cell lines treated with glucose.

Methods: Human gingival fibroblast (hGF), colorectal adenocarcinoma (HT29), and skin malignant melanoma (A375) cell lines were cultured and treated with additional glucose in three respective concentrations: 1 mg/ml, 5 mg/ml, and 10 mg/ml. Then, cell viability was measured using an MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide)-assay. The data were analyzed using ...


Guide Lines Vol. Ii, Issue 2 - April 2020, College Of Health And Human Services Apr 2020

Guide Lines Vol. Ii, Issue 2 - April 2020, College Of Health And Human Services

GUIDE Lines

Periodic Newsletter of the Governors State University - University of Illinois, Chicago - Disparities Education Cancer research training and education project (The GUIDE Project).


A Literature Review On Intermittent Fasting, Kylie Carrero Apr 2020

A Literature Review On Intermittent Fasting, Kylie Carrero

Senior Honors Theses

Intermittent fasting has been instructed in the Bible as an implied part of daily living. This paper has reviewed the physical benefits of intermittent fasting. In healthy test subjects, it has led to higher levels of autophagy, gut health, and lifespan. In non-healthy test subjects, it has proven beneficial in cancer treatment, as well as in protection against and/or attenuation of the effects of neurodegeneration, metabolic disorders, and cardiovascular diseases. The possible mechanisms underlying these benefits have been discussed in this review.


Utilizing Digital Health To Collect Electronic Patient-Reported Outcomes In Prostate Cancer: Single-Arm Pilot Trial, Christine Tran, Ms, Adam Dicker, Md, Phd, Benjamin Leiby, Phd, Eric Gressen, Md, Noelle Williams, Md, Heather Jim, Phd Mar 2020

Utilizing Digital Health To Collect Electronic Patient-Reported Outcomes In Prostate Cancer: Single-Arm Pilot Trial, Christine Tran, Ms, Adam Dicker, Md, Phd, Benjamin Leiby, Phd, Eric Gressen, Md, Noelle Williams, Md, Heather Jim, Phd

Kimmel Cancer Center Faculty Papers

Background: Measuring patient-reported outcomes (PROs) requires an individual’s perspective on their symptoms, functional status, and quality of life. Digital health enables remote electronic PRO (ePRO) assessments as a clinical decision support tool to facilitate meaningful provider interactions and personalized treatment.

Objective: This study explored the feasibility and acceptability of collecting ePROs using validated health-related quality of life (HRQoL) questionnaires for prostate cancer.

Methods: Using Apple ResearchKit software, the Strength Through Insight app was created with content from validated HRQoL tools 26-item Expanded Prostate Cancer Index Composite (EPIC) or EPIC for Clinical Practice and 8-item Functional Assessment of Cancer Therapy ...


Guide Lines Vol. Ii, Issue 1 - March 2020, College Of Health And Human Services Mar 2020

Guide Lines Vol. Ii, Issue 1 - March 2020, College Of Health And Human Services

GUIDE Lines

Periodic Newsletter of the Governors State University - University of Illinois, Chicago - Disparities Education Cancer research training and education project (The GUIDE Project).


The Cancer Microbiome: Distinguishing Direct And Indirect Effects Requires A Systemic View, Joao B. Xavier, Amir Mitchell Mar 2020

The Cancer Microbiome: Distinguishing Direct And Indirect Effects Requires A Systemic View, Joao B. Xavier, Amir Mitchell

Open Access Articles

The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and ...


Evaluating The Needs Of Cancer Survivors Through Focus Groups And Surveillance Data, Maria George Mph, Taylor Seaton Ms, Debbie Webster Bsn, Rn, Lmsw, Diana Haggerty Ms Feb 2020

Evaluating The Needs Of Cancer Survivors Through Focus Groups And Surveillance Data, Maria George Mph, Taylor Seaton Ms, Debbie Webster Bsn, Rn, Lmsw, Diana Haggerty Ms

Michigan Journal of Public Health

Abstract:

Introduction

As cancer prevention and treatment advances, cancer survival rates continue to increase. The growing population of cancer survivors have unique needs that must be addressed to improve quality of life throughout the cancer-care continuum.

Methods

Using data compiled from the 2015 Michigan Behavioral Risk Factor Survey (MiBRFS), the Cancer Registry, and focus groups, several areas of need amongst cancer survivors were identified.

Results

In focus groups cancer survivors identified the 27 needs that fell into three categories: improving health-related behavior, utilizing health care services, and receiving emotional support. The MiBRFS provided population estimates for 10 of the 27 ...


A Brief Educational Intervention Enhances Basic Cancer Literacy Among Kentucky Middle And High School Students, Lauren Hudson, Kerrigan M. Samons, Haley E. Dicken, Chris Prichard, L. Todd Weiss, Jean Edward, Robin C. Vanderpool, Nathan L. Vanderford Jan 2020

A Brief Educational Intervention Enhances Basic Cancer Literacy Among Kentucky Middle And High School Students, Lauren Hudson, Kerrigan M. Samons, Haley E. Dicken, Chris Prichard, L. Todd Weiss, Jean Edward, Robin C. Vanderpool, Nathan L. Vanderford

Markey Cancer Center Faculty Publications

Kentucky experiences the highest overall cancer incidence and mortality rates in the USA with the greatest burden in the eastern, Appalachian region of the state. Cancer disparities in Kentucky are driven in part by poor health behaviors, poverty, lack of health care access, low education levels, and low health literacy. Individuals with inadequate health literacy are less likely to participate in preventive measures such as obtaining screenings and making healthy lifestyle choices, thus increasing their chances of developing and dying from cancer. By increasing cancer literacy among youth and adults, it may be possible to decrease cancer disparities across Kentucky ...


Barn-Raising On The Digital Frontier: The L.A.U.N.C.H. Collaborative, Bradford W. Hesse, David Ahern, Michele Ellison, Eliah Aronoff-Spencer, Robin C. Vanderpool, Karen Onyeije, Michael C. Gibbons, Timothy W. Mullett, Ming-Yuan Chih, Victoria Attencio, Grant Patterson, Jessica Boten, Christopher Hartshorn, Ben Bartolome, Katie Gorscak, Melanie Mccomsey, Alexandra Hubenko, Bin Huang, Corey Baker, Don Norman Jan 2020

Barn-Raising On The Digital Frontier: The L.A.U.N.C.H. Collaborative, Bradford W. Hesse, David Ahern, Michele Ellison, Eliah Aronoff-Spencer, Robin C. Vanderpool, Karen Onyeije, Michael C. Gibbons, Timothy W. Mullett, Ming-Yuan Chih, Victoria Attencio, Grant Patterson, Jessica Boten, Christopher Hartshorn, Ben Bartolome, Katie Gorscak, Melanie Mccomsey, Alexandra Hubenko, Bin Huang, Corey Baker, Don Norman

Journal of Appalachian Health

A meta-analysis of oncology papers from around the world revealed that cancer patients who lived more than 50 miles away from hospital centers routinely presented with more advanced stages of disease at diagnosis, exhibited lower adherence to prescribed treatments, presented with poorer diagnoses, and reported a lower quality of life than patients who lived nearer to care facilities. Connected health approaches—or the use of broadband and telecommunications technologies to evaluate, diagnose, and monitor patients beyond the clinic—are becoming an indispensable tool in medicine to overcome the obstacle of distance.


Introducing The L.A.U.N.C.H. Collaborative, F. Douglas Scutchfield Md, Kevin Patrick Jan 2020

Introducing The L.A.U.N.C.H. Collaborative, F. Douglas Scutchfield Md, Kevin Patrick

Journal of Appalachian Health

The L.A.U.N.C.H. Collaborative: Linking & Amplifying User-Centered Networks through Connected Health: A Demonstration of Broadband-Enabled Connected Health and Community-Based Co-Design brings together a group of organizations that are eager to use Appalachian Kentucky as a site for the development of a project aimed at creating an environment that addresses two of the nation’s major concerns about cancer. First, individuals who live in rural and remote areas are more likely to die of cancer than those who live in urban or suburban settings. And second, geographic obstacles hinder their ability to access evidence-based strategies that can ...


The Use Of Ipad Tablets And Online Videos For Oncology Patient Education To Increase Patient Knowledge And Satisfaction, Tiffany Brown Jan 2020

The Use Of Ipad Tablets And Online Videos For Oncology Patient Education To Increase Patient Knowledge And Satisfaction, Tiffany Brown

DNP Qualifying Manuscripts

Abstract

Purpose/Objectives: To provide an overview of the efficacy of using iPad tablets and online education videos to provide cancer related patient education to increase patient knowledge and satisfaction.

Data Sources: A literature search for peer-reviewed articles from 2009-2019. Databases searched include Cochrane, CINAHL, and PubMed. English language terms utilized: waiting, patient experience, patient satisfaction, cancer, positive distraction, oncology, music, patient education, iPad, television, and online education. 10 articles will be utilized for this review.

Conclusions: Patient education videos by way of iPads are more effective in increasing patient knowledge and patient satisfaction when compared to the standard pamphlet ...


Cancer Health Disparities Among African Americans: A Socioecological Approach, Seth M. Spitzley Jan 2020

Cancer Health Disparities Among African Americans: A Socioecological Approach, Seth M. Spitzley

The Hilltop Review

Research shows that health outcomes are influenced by race or ethnicity, socioeconomic status, education and literacy levels, and the physical environment (U.S. Department of Health and Human Services, 2014). The health statuses of minority groups, such as African Americans, are adversely impacted by inequality (Randall, 2009). In Kalamazoo, Michigan, the leading cause of death for all residents in Kalamazoo County was cancer, where black individuals have the highest death rate among any other racial or ethnic group. That African Americans comprise less than 11% of the population in Kalamazoo County thus suggests that African Americans are disproportionately impacted by ...


The Financial And Psychosocial Impact Of Medicinal Cannabis, Chris Ahmed, Andrew Lee, Amanda Campbell, Gregory Garber, Msw, Lcsw, Neil D. Palmisiano, Md, Brooke Worster, Md Jan 2020

The Financial And Psychosocial Impact Of Medicinal Cannabis, Chris Ahmed, Andrew Lee, Amanda Campbell, Gregory Garber, Msw, Lcsw, Neil D. Palmisiano, Md, Brooke Worster, Md

Phase 1

Introduction: Therapeutic utilization of medicinal cannabis for symptom management in oncology patients is a burgeoning area of research focus. We hypothesize that medicinal cannabis use can result in subjective improvements in quality of life (QOL) metrics for cancer patients.

Methods: Adult palliative care patients at a medical oncology clinic are consented to the study after being certified to access medicinal cannabis. After three months, subjective changes in QOL, including well-being, financial burden, pain, chemotherapy induced nausea and vomiting (CINV), and other categories are recorded via telephone interview. Responses are documented with a numerical Likert scale (from 1-5, with a score ...


Evaluating Colorectal Cancer Screening Rates In An Urban Primary Care Practice, Kristen Makowski Jan 2020

Evaluating Colorectal Cancer Screening Rates In An Urban Primary Care Practice, Kristen Makowski

DNP Projects

Colorectal cancer accounts for 8% of all cancer deaths and can be prevented through timely removal of colon polyps. Despite recommendations for routine screening, approximately 31.2% of patients go unscreened for this disease (Centers for Disease Control and Prevention, 2018). The purpose of this project was to determine screening rates and documentation mechanisms for colorectal cancer in an urban primary care practice, to determine how many patients completed the screening, and to present findings to the practice providers along with exploring ways to increase screenings. An additional purpose of this project was to determine and identify patient demographics which ...


Investigations Of A Low Carbohydrate Ketogenic Diet As A Possible Treatment For Malignant Brain Tumors, Elizabeth Anaya Jan 2020

Investigations Of A Low Carbohydrate Ketogenic Diet As A Possible Treatment For Malignant Brain Tumors, Elizabeth Anaya

All Regis University Theses

Cancer is now the leading cause of premature death in the U.S. and second worldwide. However, all cancers on average have seen a 20% increase in 5-year survival in the last 30 years. This is not true for brain cancers which have only seen a 1% increase. Brain cancer is extremely hard to treat, costing the most money out of any other cancer. Nevertheless, Otto Warburg’s investigation of cancer as a metabolic disease has led to a variety of new promising treatments. One of these treatments involves starving cancer cells by cutting off their access to glucose, a ...


The Effects Of Autophagy And Senescence On Sensitivity To Cisplatin In Head And Neck Cancer, Zara H. Siddiqui Jan 2020

The Effects Of Autophagy And Senescence On Sensitivity To Cisplatin In Head And Neck Cancer, Zara H. Siddiqui

Theses and Dissertations

While current treatments in cancer, such as chemotherapy and radiation, can generally be effective in eliminating disease in patients, there also exists the possibility of recurrence of cancer cells over time. In patients diagnosed with locally advanced head and neck carcinoma, about 50-60% develop a loco-regional recurrence within two years, and 20-30% of patients develop metastatic disease at distant sites in the body [5]. On a cellular level, one mechanism for this survival may be that natural mechanisms such as autophagy and senescence play a role in allowing cells to survive after undergoing treatment. One standard of care chemotherapy for ...


Caring For Young Adults With Cancer: A Systematic Review, Sarah M. Pelletier Jan 2020

Caring For Young Adults With Cancer: A Systematic Review, Sarah M. Pelletier

All Theses, Dissertations, and Other Capstone Projects

Young adulthood is unique period of life in which critical developmental milestones are achieved amid dynamic physical, emotional, and social changes. During this period of life, young adults are charged with establishing personal and social independence. When challenged with a cancer diagnosis, the already turbulent late teens, twenties, and thirties are dramatically and permanently altered. Hence, the needs of young adults vary from that of their pediatric and older adult counterparts. The aim of this systematic review of the literature was to identify what age-specific needs must be addressed by healthcare professionals to enhance quality of care and outcomes for ...