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Full-Text Articles in Medicine and Health Sciences

Financial Toxicity Tumor Board: A Multi-Disciplinary Team Activity Required In Low And Middle-Income Countries (Lmic), Ahmed Nadeem Abbasi, Sohail Rasool, Laraib Khan May 2022

Financial Toxicity Tumor Board: A Multi-Disciplinary Team Activity Required In Low And Middle-Income Countries (Lmic), Ahmed Nadeem Abbasi, Sohail Rasool, Laraib Khan

Department of Radiation Oncology

No abstract provided.


Dance Movement Therapy Interventions To Build Coping Skills And Identity In Adolescent Patients Dealing With A Cancer Diagnosis: Development Of A Method, Ariel Hortin May 2022

Dance Movement Therapy Interventions To Build Coping Skills And Identity In Adolescent Patients Dealing With A Cancer Diagnosis: Development Of A Method, Ariel Hortin

Expressive Therapies Capstone Theses

Adolescents are a special category in pediatric oncology because of their unique physical and mental development. This patient population has needs specific to both their development and cancer diagnosis. Dance Movement Therapy (DMT) focuses on building awareness of inner sensations so that the patient can then connect those observations with felt emotions and thoughts. Connecting the physical experience with the emotional experience can provide helpful information for the patient as a tool for change. Building and strengthening relationships with family members also strengthens the critical support system for the patient. Dance Movement Therapy interventions may be effective in working with ...


Antigen Staining For Detection Of Muc13 And Muc16 Expression In Carcinoma Tissue, Jose A. Benitez May 2022

Antigen Staining For Detection Of Muc13 And Muc16 Expression In Carcinoma Tissue, Jose A. Benitez

MEDI 9331 Scholarly Activities Clinical Years

MUC13 and MUC16 are epithelial expressed proteins implicated in various carcinomas. Overexpression of these biomarkers appear to play a role in tumor growth; this discovery has paved a road for multiple studies discussing the potential of targeting mucin proteins and optimize immunotherapy approaches against carcinomas. Our study serves to investigate the level of expression of MUC13 and MUC16 in cancerous and normal tissue and to discuss the implications our findings may have for the utilization of these biomarkers for cancer therapy.


Combined Treatment With Niclosamide And Camptothecin Enhances Anticancer Effect In U87 Mg Human Glioblastoma Cells, Laura Valdez, Benxu Cheng, Daniela Gonzalez, Reanna Rodriguez, Paola Campano, Andrew Tsin, Xiaoqian Fang May 2022

Combined Treatment With Niclosamide And Camptothecin Enhances Anticancer Effect In U87 Mg Human Glioblastoma Cells, Laura Valdez, Benxu Cheng, Daniela Gonzalez, Reanna Rodriguez, Paola Campano, Andrew Tsin, Xiaoqian Fang

School of Medicine Publications and Presentations

Glioblastoma multiforme (GBM) is one of the deadliest cancers of the brain. Its ability to infiltrate healthy brain tissues renders it difficult to remove surgically. Furthermore, it exhibits high rates of radio- and chemoresistance, making the survival rates of patients with GBM poor. Therefore, novel effective therapies for GBM remain urgently in demand. Niclosamide is an anti-helminthic drug and recently it has been receiving attention due to its reported anticancer effects in cancer models, including GBM. Furthermore, camptothecin (CPT) is a naturally-occurring alkaloid and has been previously reported to be a potential chemotherapeutic agent by targeting the nuclear topoisomerase I ...


The Future Of Targeted Kinase Inhibitors In Melanoma, Signe Caksa, Usman Baqai, A E Aplin May 2022

The Future Of Targeted Kinase Inhibitors In Melanoma, Signe Caksa, Usman Baqai, A E Aplin

Department of Cancer Biology Faculty Papers

Melanoma is a cancer of the pigment-producing cells of the body and its incidence is rising. Targeted inhibitors that act against kinases in the MAPK pathway are approved for BRAF-mutant metastatic cutaneous melanoma and increase patients' survival. Response to these therapies is limited by drug resistance and is less durable than with immune checkpoint inhibition. Conversely, rare melanoma subtypes have few therapeutic options for advanced disease and MAPK pathway targeting agents show minimal anti-tumor effects. Nevertheless, there is a future for targeted kinase inhibitors in melanoma: in new applications such as adjuvant or neoadjuvant therapy and in novel combinations with ...


Expanding The Role Of Occupational Therapy For Oncology Patients: A Focus On Tumor- And Blood-Based Cancers, Erika N. Clark May 2022

Expanding The Role Of Occupational Therapy For Oncology Patients: A Focus On Tumor- And Blood-Based Cancers, Erika N. Clark

Occupational Therapy Capstone Presentations

Tumor and blood-based cancer diagnosis rates are increasing rapidly in the United States. To improve survivorship, treatment practices are constantly evolving, however, patients are often left to face the consequences of survival. With decreased range of motion, strength, and ability to participate in desired activities, patients may experience a decrease in overall quality of life. Through a holistic lens, occupational therapists are well suited to address the diverse needs of cancer patients through the duration of their cancer treatments. Unfortunately, occupational therapy remains a widely underutilized service for this population. This capstone experience worked to address this gap by expanding ...


The Ketogenic Diet: Its Effectiveness As An Adjuvant Therapy For Cancer, Rheaonn Marin May 2022

The Ketogenic Diet: Its Effectiveness As An Adjuvant Therapy For Cancer, Rheaonn Marin

Nursing | Senior Theses

This paper explores a total of six research studies and will contain a literature review and proposal for further study regarding the effectiveness of the ketogenic diet as an adjuvant cancer therapy. Each study addresses a variety of different factors involved in KD implementation, ranging from effects on body composition and lipid profiles, to self-proclaimed quality of life, to tumor expression and progression under a KD regime. Ultimately, each were divided into three separate categories depending on the aspects of research that were covered. Two studies, by Hagihara et.al and Jansen and Walach respectively, discuss the potential benefits of ...


Dnp Final Report: Psychosocial Screening For Oncology Patients, Robyn V. Beard Apr 2022

Dnp Final Report: Psychosocial Screening For Oncology Patients, Robyn V. Beard

DNP Final Reports

Background: Patients with cancer often face severe distress related to fear of death, body disfigurement, financial stress, and lack of support system. This distress may lead to physical and emotional symptoms that bring patients to seek care at emergency departments, delay care or make poor health choices, and increase utilization of prescription drugs. With the already over burdened healthcare system, addressing these psychosocial needs is vital to improving patients outcomes as well as improving healthcare expenditure. Purpose: The purpose of this evidence based practice project was to improve perceived quality of life for oncology patients through detailed screening and behavioural ...


The Effects Of Paclitaxel On Cellular Migration And The Cytoskeleton, Ashley Salguero-Gonzalez Apr 2022

The Effects Of Paclitaxel On Cellular Migration And The Cytoskeleton, Ashley Salguero-Gonzalez

Thinking Matters Symposium

In a clinical setting, some patients are exposed to an anti-cancer chemotherapy agent, paclitaxel. Cancerous cells undergo rapid, continuous cell division without control. Chemotherapy treatments try to slow and stop the uncontrollable cell division cycles and eliminate cancerous cells in the process. Paclitaxel serves as a treatment for some types of cancers, including lung, melanoma, bladder, and esophageal. Because it targets the cytoskeleton, paclitaxel can also influence cell migration. This project utilizes a cellular migration assay and an immunohistochemistry assay to analyze the effects of paclitaxel on the movement of cells and on the cytoskeleton of neuroglia rat cells with ...


Developing Novel Water-Soluble Porphyrins For Potential Use As Photosensitizers In Photodynamic Therapy, Kayla R. Whittington Apr 2022

Developing Novel Water-Soluble Porphyrins For Potential Use As Photosensitizers In Photodynamic Therapy, Kayla R. Whittington

Honors Theses

Photodynamic therapy (PDT) is a treatment modality for various illnesses, including some types of cancer. Lung cancer is the leading cause of cancer death in the United States. The prevalence of lung cancer in certain gender, racial, ethnic, and socioeconomic groups add to existing health disparities in the United States. For this reason, it is necessary to address the social determinants underlying lung cancer disparities, as well as improve treatment options. These treatment options should be cost effective, convenient, and increase survival rates. This research focused on synthesizing novel water-soluble porphyrin compounds for use as photosensitive agents in PDT for ...


The Impact Of Dietary Fiber On Breast Cancer Incidence, Peyton North Apr 2022

The Impact Of Dietary Fiber On Breast Cancer Incidence, Peyton North

Epsilon Sigma at-Large Research Conference

Abstract

Introduction & Background

The role of dietary fiber in breast cancer etiology remains unclear. A negative correlation may be due to fiber’s ability to stave off obesity and aid in the extraction of serum estrogen, two known risk factors for the disease. Effects may differ by source, and type, of fiber. Most of the data available is from research with non-Hispanic white women. However, fiber intake may vary significantly across cultures.

Purpose Statement & Question

The research sought to investigate whether an increased intake of dietary fiber was associated with a corresponding decrease in the incidence of breast cancer. The ...


Intercellular Mitochondrial Transfer Using 3d Bioprinting, Julie Bjerring, Patrick C. Sachs, Robert D. Bruno Apr 2022

Intercellular Mitochondrial Transfer Using 3d Bioprinting, Julie Bjerring, Patrick C. Sachs, Robert D. Bruno

College of Health Sciences Posters

Mitochondria are one of the most complex and vital organelles in eukaryotic cells. In recent years, it has been shown that through intercellular mitochondrial transfer, this important organelle provides a critical role in tissue homeostasis, damaged tissue repair, and tumor progression under physiological conditions. However, the mechanism of mitochondrial transfer and its effect on various cellular microenvironments has not yet been defined. Understanding the metabolic effects of mitochondrial transfer between cells and exploring the signaling leading to the intercellular mechanisms could provide advancements in both translational medicine and cell therapy for cancer progression and age-related diseases. Our group has studied ...


The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson Apr 2022

The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson

Senior Honors Theses

The mammalian target of rapamycin complex 1, mTORC1, is composed of several subunit proteins with many cellular responsibilities including participation in a complex cell signaling cascade leading to autophagy, which is the regulated degradation of cell components. mTORC1 is frequently mutated or dysregulated within human cancer. Normally, mTORC1 functions to provide efficient regulation of autophagy according to intracellular levels of growth factors, amino acids, nutrients, oxygen levels, and more that can either inhibit mTORC1 and upregulate autophagy or activate mTORC1 and downregulate autophagy. A better understanding of mTORC1 is imperative to preparing cancer therapy treatments. Various cancerous tissue types require ...


T Cell Therapy: Underlying Mechanisms And Current Advancements, Griffin Mccloy Apr 2022

T Cell Therapy: Underlying Mechanisms And Current Advancements, Griffin Mccloy

Senior Honors Theses

As the second leading cause of death in 2016, cancer is one of the most serious diseases facing the world today. T cell therapy is a current area of research attempting to address the disease with two primary division: CAR-T and TCR-T cell therapy. The immune system naturally produces T lymphocytes to aid in the recognition and removal of cells infected with viruses or transformed into cancer. Under normal circumstances, T lymphocytes identify and destroy cancerous cells; however, some cancerous cell types can evade this system. With the use of genetic editing technology, T lymphocytes can gain the ability to ...


Correlation Between New-Onset Atrial Fibrillation And Cancer, Monica Soliman, Carlos Rodríguez Pellicer, Alejandro Herreros-Pomares, Aurelio Quesada Dorador, Francisco Javier Quesada Ocete, Fernando Vidal-Vanaclocha Apr 2022

Correlation Between New-Onset Atrial Fibrillation And Cancer, Monica Soliman, Carlos Rodríguez Pellicer, Alejandro Herreros-Pomares, Aurelio Quesada Dorador, Francisco Javier Quesada Ocete, Fernando Vidal-Vanaclocha

GW Research Showcase 2021-

No abstract provided.


The Effects Of Floatation-Rest On Cortisol Levels Of Patients With Glioblastoma Grade Iv: A Conceptual Framework, Hilario Gomez Apr 2022

The Effects Of Floatation-Rest On Cortisol Levels Of Patients With Glioblastoma Grade Iv: A Conceptual Framework, Hilario Gomez

Selected Honors Theses

Glioblastoma is reported to be the most aggressive and common brain tumor in adults (Davis, 2016). To help alleviate pain in patients with glioblastoma, floatation-REST (Restricted Environmental Stimulation Technique) is proposed. Such therapy has been shown to benefit chronic tension headaches, muscle tension, and other stress-related pain conditions (Feinstein, 2018). The magnesium and sulfate components of Epsom salt combined with controlled warm water allow the muscles and joints to relax. Studies show that magnesium targets the Adrenocorticotropic Hormone (ACTH) produced by the Anterior Pituitary Gland which in turn affects cortisol hormone levels to activate the body's immune defenses and ...


An Analysis Of The Psychological And Physical Effects Of A Physical Activity Program During In-Patient Pediatric Cancer Treatment, Zoë Winters Apr 2022

An Analysis Of The Psychological And Physical Effects Of A Physical Activity Program During In-Patient Pediatric Cancer Treatment, Zoë Winters

Undergraduate Theses

There is limited published research regarding the use of physical activity in cancer treatment programs, and even fewer in pediatric treatment plans; however, there is a common consensus that following the conclusion of cancer treatment an individual’s physical fitness has been majorly impacted. The inactivity that commonly coexists with cancer treatment often results in extended periods of time in rehabilitation programs and decreased independence. Along with the physical detriments caused by inactivity, increased dependence on others often brings about feelings of helplessness that can further cause emotional detriments. It has however been demonstrated in previous research that adding physical ...


Survivorship Research For People With Metastatic Or Advanced Cancer: A Time For Action, Andrea L. Smith, Nicolas H. Hart, Michael Jefford, Raymond J. Chan Apr 2022

Survivorship Research For People With Metastatic Or Advanced Cancer: A Time For Action, Andrea L. Smith, Nicolas H. Hart, Michael Jefford, Raymond J. Chan

Research outputs 2022 to 2026

Over recent decades, survival outcomes for people diagnosed with cancer have changed dramatically, with approximately 20% improvement in five-year relative survival rates in high-income countries including the United States and Australia. Regardless of regions, there is a decrease in overall cancer mortality rate of about 1% per year. Likewise, the cancer disease trajectory has changed. The traditional linear cancer trajectory in which a patient moves from cancer diagnosis through to a binary outcome (cure or death)—is no longer applicable and does not adequately describe the complexity of experience for many people. Indeed, the availability of targeted therapies and immunotherapies ...


The Incidence And The Type Of Stomatognathic Disorders In Patients With Gardner Syndrome. A Systematic Review, Olga Preuss, Aleksandra Jaron, Anna Grzywacz, Magda Aniko-Wlodarczyk, Grzegorz Trybek Mar 2022

The Incidence And The Type Of Stomatognathic Disorders In Patients With Gardner Syndrome. A Systematic Review, Olga Preuss, Aleksandra Jaron, Anna Grzywacz, Magda Aniko-Wlodarczyk, Grzegorz Trybek

Baltic Journal of Health and Physical Activity

Background: Diseases of genetic origin are very often associated with oral disorders. One of them is Gardner syndrome (GS) a rare variant of familial adenomatous polyposis (FAP), whose main manifestation is colon cancer. Its most common oral cavity symptoms include osteomas, odontomas and impacted or supernumerary teeth. Material and methods: Medline (PubMed), Medline (Ebsco), Scopus and Google Scholar databases were searched oral manifestations of Gardner Syndrome.Results: Thirty-eight articles met inclusion criteria. The most frequently mentioned oral changes included osteomas, impacted teeth, supernumerary teeth and odontomas. Conclusion: This review provides evidence for associating FAP with oral disorders. Dentists can be ...


The Experiences And Needs Of Individuals With A Variant Of Uncertain Significance (Vus) On Genetic Tests For Hereditary Cancer Syndromes: A Grounded Theory Study, Danielle Gould Mar 2022

The Experiences And Needs Of Individuals With A Variant Of Uncertain Significance (Vus) On Genetic Tests For Hereditary Cancer Syndromes: A Grounded Theory Study, Danielle Gould

Doctoral Dissertations

Background: The use of multigene panel testing for identifying individuals with hereditary cancer susceptibility has expanded in recent years. The number of individuals who have a variant of unknown significance (VUS) result is increasing. However, little is known about the experiences and needs of this group. This study’s purpose was to describe the experiences and needs of individuals with a VUS result by focusing on their experiences in communicating with healthcare providers and family members. Methods: A constructivist grounded theory approach was used. Recruitment took place from January–July 2021 through social media: the Prospective Registry of Multiplex Testing ...


Sportsman’S Authority In The Perspective Of Man’S Weakness, Marcin Pasek Mar 2022

Sportsman’S Authority In The Perspective Of Man’S Weakness, Marcin Pasek

Baltic Journal of Health and Physical Activity

Background: History of glory and fall of the cyclist Lance Armstrong refers to the issues from the borderline of sociology, psychology, pharmacology and qualified sport. It stirs many emotions and extreme opinions in which human attitudes are focused on phenomena impossible to be interpreted unequivocally. The purpose of this research was to learn opinions on the life path of Lance Armstrong, regarding his struggle both with cancer and his rivals in the peloton, but at the same time marked with forbidden doping. Material and methods: The research was carried out using the survey method, which asked one question about the ...


Risk And Outcome Of Breakthrough Covid-19 Infections In Vaccinated Patients With Cancer: Real-World Evidence From The National Covid Cohort Collaborative, Qianqian Song, Benjamin Bates, Yu Raymond Shao, Fang-Chi Hsu, Feifan Liu, Vithal Madhira, Amit Kumar Mitra, Timothy Bergquist, Ramakanth Kavuluru, Xiaochun Li, Noha Sharafeldin, Jing Su, Umit Topaloglu Mar 2022

Risk And Outcome Of Breakthrough Covid-19 Infections In Vaccinated Patients With Cancer: Real-World Evidence From The National Covid Cohort Collaborative, Qianqian Song, Benjamin Bates, Yu Raymond Shao, Fang-Chi Hsu, Feifan Liu, Vithal Madhira, Amit Kumar Mitra, Timothy Bergquist, Ramakanth Kavuluru, Xiaochun Li, Noha Sharafeldin, Jing Su, Umit Topaloglu

UMass Center for Clinical and Translational Science Supported Publications

PURPOSE: To provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort of COVID-19 cases and controls.

METHODS: We used the National COVID Cohort Collaborative (N3C) to identify breakthrough infections between December 1, 2020, and May 31, 2021. We included patients partially or fully vaccinated with mRNA COVID-19 vaccines with no prior SARS-CoV-2 infection record. Risks for breakthrough infection and severe outcomes were analyzed using logistic regression.

RESULTS: A total of 6,860 breakthrough cases were identified within the N3C-vaccinated population, among whom 1,460 (21.3%) were patients ...


Editorial: Anticancer Potential Of Artemisia Annua, Jill M. Kolesar, Peter H. Seeberger Feb 2022

Editorial: Anticancer Potential Of Artemisia Annua, Jill M. Kolesar, Peter H. Seeberger

Pharmacy Practice and Science Faculty Publications

No abstract provided.


Challenges And Opportunities For Immunotherapeutic Intervention Against Myeloid Immunosuppression In Glioblastoma, Mark A Exley, Samantha Garcia, Amelia Zellander, Jenny Zilberberg, David W. Andrews Feb 2022

Challenges And Opportunities For Immunotherapeutic Intervention Against Myeloid Immunosuppression In Glioblastoma, Mark A Exley, Samantha Garcia, Amelia Zellander, Jenny Zilberberg, David W. Andrews

Department of Neurosurgery Faculty Papers

Glioblastoma multiforme (GBM), the most common and deadly brain cancer, exemplifies the paradigm that cancers grow with help from an immunosuppressive tumor microenvironment (TME). In general, TME includes a large contribution from various myeloid lineage-derived cell types, including (in the brain) altered pathogenic microglia as well as monocyte-macrophages (Macs), myeloid-derived suppressor cells (MDSC) and dendritic cell (DC) populations. Each can have protective roles, but has, by definition, been coopted by the tumor in patients with progressive disease. However, evidence demonstrates that myeloid immunosuppressive activities can be reversed in different ways, leading to enthusiasm for this therapeutic approach, both alone and ...


Dna-Pkcs: A Targetable Protumorigenic Protein Kinase., Emanuela Dylgjeri, Karen E Knudsen Feb 2022

Dna-Pkcs: A Targetable Protumorigenic Protein Kinase., Emanuela Dylgjeri, Karen E Knudsen

Department of Cancer Biology Faculty Papers

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.


Choosing To Thrive: An Autoethnographic Journey Of Cancer, Companionship, And Carrots, Bruce Lilyea Feb 2022

Choosing To Thrive: An Autoethnographic Journey Of Cancer, Companionship, And Carrots, Bruce Lilyea

The Qualitative Report

In this autoethnography, I explore the companionship experience of someone supporting a cancer patient who is endeavoring to thrive in the face of this disease. A wide range of studies has been conducted on the emotional and social issues relating to cancer and specifically to breast cancer. Appropriately, most of the research relating to the personal narrative focuses on the stories of the person who has been diagnosed with cancer, and limited research has highlighted the perspective and experiences of their companions. My primary goals for this autoethnographic research are to: (1) Begin to answer the question: What role do ...


Positive Selection And Enhancer Evolution Shaped Lifespan And Body Mass In Great Apes, Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro De Magalhães, Marco Trizzino Feb 2022

Positive Selection And Enhancer Evolution Shaped Lifespan And Body Mass In Great Apes, Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro De Magalhães, Marco Trizzino

Department of Biochemistry and Molecular Biology Faculty Papers

Within primates, the great apes are outliers both in terms of body size and lifespan, since they include the largest and longest-lived species in the order. Yet, the molecular bases underlying such features are poorly understood. Here, we leveraged an integrated approach to investigate multiple sources of molecular variation across primates, focusing on over 10,000 genes, including approximately 1,500 previously associated with lifespan, and additional approximately 9,000 for which an association with longevity has never been suggested. We analyzed dN/dS rates, positive selection, gene expression (RNA-seq), and gene regulation (ChIP-seq). By analyzing the correlation between dN ...


Risk Factors For Hospitalizations Among Older Adults With Gastrointestinal Cancers, Daneng Li, Can-Lan Sun, Rebecca Allen, Christiana J Crook, Abrahm Levi, Richard Ballena, Heidi D Klepin, Rawad Elias, Supriya G Mohile, William P Tew, Cynthia Owusu, Hyman B Muss, Stuart M Lichtman, Cary P Gross, Andrew Chapman, Ajeet Gajra, Harvey J Cohen, Vani Katheria, Arti Hurria, William Dale Feb 2022

Risk Factors For Hospitalizations Among Older Adults With Gastrointestinal Cancers, Daneng Li, Can-Lan Sun, Rebecca Allen, Christiana J Crook, Abrahm Levi, Richard Ballena, Heidi D Klepin, Rawad Elias, Supriya G Mohile, William P Tew, Cynthia Owusu, Hyman B Muss, Stuart M Lichtman, Cary P Gross, Andrew Chapman, Ajeet Gajra, Harvey J Cohen, Vani Katheria, Arti Hurria, William Dale

Department of Medical Oncology Faculty Papers

Background: Older adults (≥65 years) with gastrointestinal (GI) cancers who receive chemotherapy are at increased risk of hospitalization caused by treatment-related toxicity. Geriatric assessment (GA) has been previously shown to predict risk of toxicity in older adults undergoing chemotherapy. However, studies incorporating the GA specifically in older adults with GI cancers have been limited. This study sought to identify GA-based risk factors for chemotherapy toxicity-related hospitalization among older adults with GI cancers.

Patients and methods: We performed a secondary post hoc subgroup analysis of two prospective studies used to develop and validate a GA-based chemotherapy toxicity score. The incidence of ...


A Narrative Review Of The Evidence For Variations In Serum 25-Hydroxyvitamin D Concentration Thresholds For Optimal Health, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinç Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski Feb 2022

A Narrative Review Of The Evidence For Variations In Serum 25-Hydroxyvitamin D Concentration Thresholds For Optimal Health, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinç Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski

All Works

Vitamin D3 has many important health benefits. Unfortunately, these benefits are not widely known among health care personnel and the general public. As a result, most of the world’s population has serum 25-hydroxyvitamin D (25(OH)D) concentrations far below optimal values. This narrative review examines the evidence for the major causes of death including cardiovascular disease, hypertension, cancer, type 2 diabetes mellitus, and COVID-19 with regard to sub-optimal 25(OH)D concentrations. Evidence for the beneficial effects comes from a variety of approaches including ecological and observational studies, studies of mechanisms, and Mendelian randomization studies. Although randomized controlled ...


3d Bioprinting And Implantation Of Mouse Mammary Epithelial Structures Using A Custom Accessible 3d Bioprinting Platform, Xavier-Lewis Palmer, Saad Jafri, Patrick C. Sachs, Robert D. Bruno Jan 2022

3d Bioprinting And Implantation Of Mouse Mammary Epithelial Structures Using A Custom Accessible 3d Bioprinting Platform, Xavier-Lewis Palmer, Saad Jafri, Patrick C. Sachs, Robert D. Bruno

College of Engineering & Technology (Batten) Posters

Prior work has shown that our bioprinting system can reliably produce human mammary organoids and tumoroids with high precision. However, this was not previously applied to mouse models, which are also important with respect to translational research in cancer drug development. To address this, we have produced protocols for the development of in vitro structures from murine mammary epithelial and tumor cells. Additionally, we assessed the translatability of both human and murine bioprinted organoids into mouse mammary fat pads over a period of 6 weeks. Our lab found that our produced organoids are reliable, they can survive in vivo, and ...