Medicine and Health Sciences Commons^™

The Influences Of Medical Students' Consent To Participate In Thalassemia Research, Raditya Wratsangka, Donna Adriani, Endrico Xavierees Tungka, Aditya Krishna Murthi

Kesmas

An effective way of learning about thalassemia, a complex public health issue with multiple perspectives, is through participating in research. This study used an inductive approach to presume the influencing factors of students' consent to participate in thalassemia research voluntarily. Nested in the preliminary stage of a research series on thalassemia, this study used a consecutive sampling to recruit 140 medical undergraduates. Their knowledge, experience, and attitude to thalassemia and the perception of self-quality life were assessed using self-administered questionnaires. Blood samples were drawn for carrier screening. Students' GPAs were collected from faculty records. Of 140 participants, only 123 had …

Analysis Of Factors Affecting Hospital Risk Management In Indonesia: The Sem-Pls Approach, Dihartawan Dihartawan, Fatma Lestari, Baiduri Widanarko, Besral Besral

Kesmas

Healthcare workers, especially those in hospitals, face a variety of complex hazards and exposures. One of the essential aspects of reducing risks and dangers is effective risk management. This study used a cross-sectional approach to survey the implementation of occupational health and safety management systems in Indonesian hospitals and to identify factors predisposing hospital risk management in Indonesia. A purposive sampling method was employed to select 90 hospitals distributed across 10 provinces in Indonesia. Data were analyzed using descriptive analysis, correlation, and SEM-PLS. A total of 44 hospitals (48.9%) had complete status plenary, and the majority were type C hospitals …

Performance Of Stunting Reduction Acceleration Team: An Explorative-Qualitative Study In Indonesia-Timor Leste Border Area, Maria Paula Marla Nahak, Veronika Nitsae

Kesmas

Stunting is a complex issue influenced by multiple factors, including specific factors within and outside the health sector. Achieving a significant reduction in stunting needs the involvement of relevant local government offices in the Stunting Reduction Acceleration Team (SRAT). This study aimed to investigate SRAT performance in a specific context of accelerating stunting reduction in Malaka District. This qualitative study, with a phenomenological approach, was conducted in Malaka District, Indonesia, and Timor Leste Border Area from July to September 2023. This study revealed four major themes of SRAT performance to accelerate stunting reduction in Malaka District: activities to accelerate stunting …

Individual Longitudinal Changes In Dna-Methylome Identify Signatures Of Early-Life Adversity And Correlate With Later Outcome, Annabel K. Short, Ryan Weber, Noriko Kamei, Christina Wilcox Thai, Hina Arora, Ali Mortazavi, Hal S. Stern, Laura M. Glynn, Tallie Z. Baram

Psychology Faculty Articles and Research

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas the enduring impact of ELA on cognitive and emotional health is established, there are no tools to predict vulnerability to ELA consequences in an individual child. Epigenetic markers including peripheral-cell DNA-methylation profiles may encode ELA and provide predictive outcome markers, yet the interindividual variance of the human genome and rapid changes in DNA methylation in childhood pose significant challenges. Hoping to mitigate these challenges we examined the relation of several ELA dimensions to DNA methylation changes and outcome using a within-subject longitudinal design and a high methylation-change threshold. …

Comparative Analysis Of Doxycycline And Ayurvedic Herbs To Target Metastatic Breast Cancer: An In-Silico Approach, Acharya Balkrishna, Rashmi Mittal, Rohan Malik, Hariom Verma, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Swami Ishdev, Ajay Kumar, Vedpriya Arya

BioMedicine

Background: Metastasis of breast cancer cells to distant sites including lungs, liver, lymph node, brain and many more have substantially affected the overall survival outcome and distant metastasis free survival rate amongst the diseased individuals. Several pre-clinical and clinical studies were carried out to determine the potency of vigorous inhibitors but they extensively deteriorated the patient’s quality of life. Hence, there exists an urgent need to explore potent natural remedy to fight against metastatic breast cancer.

Methods: Ayurvedic medicinal plants documented in literature for their ability to fight against breast cancer was screened and their respective active moieties were evaluated …

In Vitro And In Silico Evaluation Of Andrographis Paniculata Ethanolic Crude Extracts On 3 Fatty Acid Synthase Expression On Breast Cancer Cells, Nur Amanina Johari, Nur Anisa Sapi’I, Alvin Lu Jiunn Hieng, Nurriza Ab Latif, Syazwani Itri Amran, Rosnani Hasham, Khairunadwa Jemon

BioMedicine

Background Fatty acid synthase (FASN), a key rate-limiting enzyme in the fatty acid biosynthesis pathway has been identified to be overexpressed in breast cancer. This overexpression has been affiliated with poor prognosis and resistance to chemotherapeutics. Consequently, FASN has come into focus as an appealing potential target for breast cancer treatment. Available FASN inhibitors, however, are unstable and have been correlated with adverse side effects. Objective This present study aims to investigate the potential of Andrographis paniculata ethanolic crude extract (AP) as a potent FASN inhibitor in breast cancer cells. Materials & Methods This study used MTT assay and flow …

Zinc Oxide Nanoparticles-Doped Curcumin-Assisted Recovery Of Rheumatoid Arthritis And Antioxidant Status In Experimental Rabbits, Shanza Azeez, Mishal Fatima, Ouz Gul, Huzaifa Rehman, Muhammad Aslam Shad, Haq Nawaz

BioMedicine

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and synovial joint destruction.

Aims: The current study investigated the possible beneficial effect of zinc oxide nanoparticles-doped curcumin (ZnONPs-DC) on the recovery of RA and antioxidant status of experimental rabbits.

Methods: RA was induced in experimental rabbits by injecting complete Freund's adjuvant and collagen type-II emulsion (100 µL/kg body weight) in the base of their tail. Arthritic rabbits were orally treated with ZnONPs, curcumin, and ZnONPs-DC (250 µL/kg body weight). Serum samples from the control and study groups were collected before and after RA induction and after treatment. …

Protection Of Gueichih-Fuling-Wan On Cerebral Ischemia-Induced Brain Injury In Rodents Is Mediated By Trans-Cinnamaldehyde Via Inhibition Of Neuroinflammation And Apoptosis, Yuh-Fung Chen, Kuo-Jen Wu, Chi-Chung Kuo, Huei-Yann Tsai

BioMedicine

Background: Stroke is the leading cause of mortality and morbidity worldwide, and an effective therapeutic strategy for the prevention of patients with cerebral ischemiainduced brain injury is lacking. Traditional Chinese medicine with neuroprotective activities might be beneficial and provide alternative therapeutic opportunities for cerebral ischemia.Purposes: This study aimed to evaluate the neuroprotection and possible mechanisms of Gueichih-Fuling-Wan (GFW), its’ constitutive herbs, and their active compounds on cerebral ischemia/reperfusion (I/R)-induced brain injury in rodents.Methods: Various doses of extracts (0.25, 0.5, and 1.0 g/kg) of GFW and five constituent herbs (Cinnamomi Cortex, CC; Poria cocos, PC; Paeonia lactifloa, PL; Paeonia suffruticosa, PS …

Glutaminase - A Potential Target For Cancer Treatment, Josephine Anthony, Sureka Varalakshmi, Ashok Kumar Sekar, Nalini Devarajan, Balamurugan Janakiraman, Rajendran Peramaiyan

BioMedicine

The overexpression of glutaminase is reported to influence cancer growth and metastasis through glutaminolysis. Upregulation of glutamine catabolism is recently recognized as a critical feature of cancer, and cancer cells are observed to reprogram glutamine metabolism to maintain its survival and proliferation. Special focus is given on the glutaminase isoform, GLS1 (kidney type glutaminase), as the other isoform GLS2 (Liver type glutaminase) acts as a tumour suppressor in some conditions. Glutaminolysis linked with autophagy, which is mediated via mTORC1, also serves as a promising target for cancer therapy. Glutamine also plays a vital role in maintaining redox homeostasis. Inhibition of …

Unveiling The Power Of Flavonoids: A Dynamic Exploration Of Their Impact On Cancer Through Matrix Metalloproteinases Regulation, Peramaiyan Rajendran

BioMedicine

Cancer is a prominent contributor to mortality rates globally, with its progression and spread being the primary factors underlying this assertion. Despite advancements in cancer therapy, the existing therapeutic strategies are rendered useless as a result of their toxicity and the development of chemoresistance. Hence, it is imperative to assess alternate therapy modalities, and natural compounds present a promising prospect due to their demonstrated anticancer capabilities in several research models. This article provides an overview of the regulatory mechanisms involved in the expression of metalloproteinases (MMPs) and explores the potential therapeutic function of flavonoids as agents with anticancer activity that …

Phytochemical Composition Of Clinacanthus Nutans Based On Factors Of Environment, Genetics And Postharvest Processes: A Review, Nurul Hamizah Sabindo, Rusidah Mat Yatim, Kannan Thirumulu Ponnuraj

BioMedicine

Herpes simplex, varicella-zoster lesions, skin rashes, diabetes, snake bites and insect bites have all been treated by using Clinacanthus nutans (C. nutans). The pharmacological effects of C. nutans are influenced by the presence of terpenoids, flavonoids, alkaloids, phenolic acids, saponins, glycosides, steroids and tannins. This review focused on the phytochemical makeup, which varies geographically and is a subject of scarcely existing knowledge. C. nutans served as the primary search term, while the keywords “phytochemicals”, “chemical component” and “phytochemistry” were used to search the literature in the Google Scholar, PubMed, Scopus and Web of Science databases. The articles pertinent to the …

Effects And Nursing Considerations For Equine-Assisted Activities And Therapies For Children With Autism Spectrum Disorders: A Literature Review, Namiko Kawamura, Mayu Sakamoto, Kayoko Machida

People and Animals: The International Journal of Research and Practice

This literature review aimed to analyze the effects and nursing challenges associated with equine-assisted activities and therapies (EAATs) for children with autism spectrum disorders (ASD). The study utilized the PubMed, CINAHL, and MEDLINE databases to identify 24 relevant articles. The effective contents were classified into two major categories: effects on interpersonal relationships, and effects attributable to the physical and emotional aspects of the lives of the children. The medical staff involved were mainly occupational therapists, followed by physical therapists and speech-language pathologists. The included studies also mention the involvement of trained equine therapists and volunteers, but not the involvement of …

A Review Of Socially Responsible Hrm Practices In The Lebanese Healthcare Sector, Maya Issam Houri, Abdul Rahman Beydoun

BAU Journal - Creative Sustainable Development

This study reviews the existing literature on Socially Responsible Human Resource Management practices on both nurses' performance and their intention to stay which constitute important factors of nurses’ decisions to stay in the healthcare sector in Lebanon. It also focuses on the current knowledge about existing literature in socially responsible HRM. This literature review highlights on the current knowledge about the determinant factor and the importance of socially responsible HRM practices and key outcomes for nurses. It suggests that socially responsible HRM practices, covering initiatives such as training, performance evaluation, compensation, work-family balance and occupational health and safety practices, may …

Effect Of Social Media On Shaping The Agenda Of The Communicator In The Jordanian Tv Channels, Amer Khaled Ahmad Dr, Hamza Mohammad Nahar, Maram Mohammad Naji Manajreh Dr

Middle East Journal of Communication Studies

The study aimed to assess the extent to which communicators at Jordanian television channels use social media platforms as an information source, and the impact of these platforms on their news and information selection priorities. This was achieved using a survey tool distributed on an equal quota sample of (150) communicators from Jordanian television channels (Jordan TV, AlMamlaka TV, Roya TV). The study found that all the study subjects used social media platforms as a source of information, with the "X platform (formerly Twitter)" being the most used platform. The statement "understanding the audience's interests and preferences to produce tailored …

Update On The Efficacy Of Aerosol Therapy Delivered To Obstructive Lung Disease Patients, Mohammed A. Amin, Hasanain Kamil Hasan, Hebatullah K. Taha, Raghda R.S. Hussein, Mohamed E.A. Abdelrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The distribution of many medications to the body via the respiratory tract system is crucial. This route has emerged as one of the most crucial techniques for the delivery of locally acting medications that can be used to treat a variety of respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD). The advantages of this focused drug delivery to the lungs over systemic administration methods include an improved therapeutic effect, a faster onset of action, and fewer systemic side effects.

Many formulations as suspension and solutions, such as bronchodilators, corticosteroids, and antibiotics have been recommended in a wide area …

A Study Of Serum Levels Of Ferritin, Hepatic And Renal Functions In Beta-Thalassemia Major (Btm) Patients Treated With Deferasirox (Dfx) Tablets, Desferioxamine (Dfo) Vial, Or Combination Of Both (Dfx + Dfo) In Thalassemia Center/Karbala, Shereen M. Mekkey, Maysam Ali Ameen, Najwa Kahtan Hadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

A category of inherited blood illnesses known as beta-thalassemias are defined by abnormalities in the synthesis of hemoglobin beta chains, which can result in a wide range of phenotypes, from severe anemia to people who show no symptoms at all. People who have thalassemia major typically experience severe anemia during the first two years of life, necessitating frequent red blood cell (RBC) transfusions.

Management of individuals with β-thalassemia is centered on appropriate, safe blood transfusions (free of transfusion-transmitted illnesses) and prevention of iron excess. Complications from iron overload are brought on by routine transfusion therapy.

This study is a retrospective …

Greenness Assessment And Development Of An Innovative Hplc Method For The Determination Of Rifaximin And Sodium Benzoate In Oral Suspension, Hani M. Hafez, Naser F. Al-Tannak, Mohamed A. Rabeh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The pharmaceutical industry has brought advancement and opportunities. However, it has also presented challenges and complexity that must be addressed. The pharmaceutical industry aims to protect public health by providing economical, effective, safe, and appropriate treatments. The analytical method monitors medication concentrations to ensure efficacy and safety. Chemical preservations protect drugs from microbes until administration. In Refax suspensions, the concentration of rifaximin (Antibacterial, API) and sodium benzoate (chemical preservative) must be determined to ensure the suspension's effectiveness, stability, and safety with regulatory standards.

An innovative HPLC method was created to monitor the concentrations of rifaximin (Antibacterial, API) and sodium benzoate …

Assessing Pharmacy Students' Knowledge And Awareness Regarding The Rational Utilization Of Antibiotics And The Issue Of Antimicrobial Resistance In Iraq, Hasanain Kamil Hasan, Mohamed Mahmoud Abdelrahman, Ali A. R. Aldallal, Hayder Ridha Salman, Montadher Mohammad Majeed, Mohammad Jabbar Hassan, Alaa Shukry Mtasher, Ahmed Majid Ibrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Introduction: The Non rational use and overall volume of antibiotic consumption in the community is one of the foremost causes of antimicrobial resistance. In developing countries like Iraq, pharmacists often dispense ‘prescription-only’ drugs, like antibiotics, to patients who do not have a prescription. The objectives of this study are to estimate the prevalence of irrational use of antibiotics bought from pharmacies and other medication outlets in some areas in Iraq, as well as to investigate the factors related with such usage.

Method: The cross-sectional face to face survey was conducted in AL Mustaqbal University, were 267 students at College of …

Development Of A Multi-Target Pharmacophore-Based Virtual Screening Agent Against Covid-19, Nashwa A. Ibrahim, Ahmed M. Gouda, Hany A. M. El-Sherief

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The worldwide outbreak of the COVID-19 pandemic compelled scientists to develop new, highly effective therapeutic approaches to fight it. Multitarget drugs have been proven to be effective in managing complex disorders. But designing multitarget drugs is a great challenge. In this study, to prevent a lack of efficacy due to viral mutation escape, a multi-target agent against the COVID-19 virus was discovered. As crucial targets, RNA-dependent RNA polymerase (RdRp), COVID-19 main protease (Mpro), and SARS-CoV-2 Nsp15 were selected. A pharmacophore model was developed using the native ligands of the chosen targets. This model was used to screen the ZINC Drug …

A Qualitative Exploration Of Well-Being In Cancer Survivorship: Implications For Counselors, Hallie M. Sylvestro, Lindsey K. Umstead, Heather Delgado, Christopher Lawrence, Keith Mobley, Kelly L. Wester, Andrew Wood

Adultspan Journal

Adult cancer survivors represent an important–and growing–population that could benefit from counseling services. This study employed consensual qualitative research to examine the well-being experiences of eight cancer survivors. Findings suggest a broad range of changes to individual well-being following cancer diagnosis and treatment, and indicate counseling can provide an ideal setting for processing such changes. Recommendations for counseling practice and future research are provided.

The Missguided Project: Bringing Awareness To The Stigmas And Miseducation Surrounding Women’S Health Through Art And Creative Research, Gwyneth Cunningham, Hayley Newton, Zeen Ari, Claire Portele, Kerlous Aziz, Madelyn Kearns

Belmont University Research Symposium (BURS)

MissGuided is a project that discusses miseducation, shame, and stigma within women's healthcare settings, and the transformative potential of storytelling and artmaking in these contexts. Women encounter systemic miseducation, leading to shame and stigma surrounding their health experiences. However, through the power of community-driven narratives and creative expression, these barriers can be dismantled. Facilitating communal dinner parties as a form of conceptual art making, we aim to explore the diverse experiences in healthcare through conversation. The accumulation of the research, dinner parties, and wellcores will be delivered through a collective cookbook which includes recipes, testimonials, and art. By sharing personal …

Blunt Cerebrovascular Injury (Bcvi): Universal Cta Neck Screening At Level 2 Trauma Center, Tamine Gogel

Doctor of Nursing Practice Projects

Blunt Cerebrovascular Injury (BCVI) refers to injuries to the vessels supplying blood to the brain, primarily carotid and vertebral arteries, and can result from trauma, resulting in stroke by vessel dissection, thrombus formation, embolization, and hemorrhage. Timely identification is crucial for effective intervention and improved outcomes. This doctoral project proposes the implementation of universal screening using Computed Tomography Angiography (CTA) of the neck during initial workup for blunt force trauma at a Level II ACS-verified trauma center. The primary objective is to mitigate potential delays in diagnosing and treating BCVI, thereby reducing the likelihood of complications. Patients ≥ 15 years …

Do Academic Advising And Levels Of Support Affect Nursing Students' Mental Health? A Cross-Sectional Study, Nashwa Ibrahim

Nursing

No abstract provided.

Evaluation Of Pain Levels And Pain Management In Patients After Elective Total Knee Replacement Surgery, Elif Karahan, Mediha Didem Koçoğlu Ağca, Sevim Çelik

Journal of Perioperative Nursing

Objective: The aim of this study was to evaluate early pain management outcomes in patients undergoing total knee arthroplasty.

Materials and methods: This descriptive cross-sectional study was conducted between 1 March and 30 September 2022. The sample consisted of 112 patients who underwent total knee replacement surgery. Data was collected during face-to-face interviews in the first 24 to 48 hours after surgery, using a patient information form and the revised American Pain Society patient outcome questionnaire (APS-POQ-R). One-way analysis of variance (ANOVA), independent-samples t test, Kruskal-Wallis test and Mann-Whitney test were used in statistical analyses. Ethical approval, institutional approval and …

Innovation In Bioinformatics: Recent Tools, Database And Involvement Of Artificial Intelligence, Aziz Ahmed, Mohd Shuaib, Abdulbasid Banga, Rizwan Ahmad

Indonesian Journal of Medical Chemistry and Bioinformatics

Bioinformatics has evolved in recent years into a crucial subject and a well-liked research area that is interconnected with many approaches and disciplines. The capacity of bioinformatics and its approaches to tackle challenging biological problems and promote research and development. There are various tools and database which are used in bioinformatics. AI is the capacity of a computational system to carry out various activities associated with intellectual beings and as a computer system's imitation of human intelligence processes. The bioinformatics applications with artificial intelligence have the capacity to annotate the data in the direction of logical conclusions. By combining AI …

Abdominal Congestion As A Predictor Of Worsening Renal Function In Patients With Acute Decompensated Heart Failure, Hossameldin Rezk, Ghada (Sayed) Youssef, Karim Said, Iman (Atef) Mandour, Magdy Abdelhamid

Journal of the Saudi Heart Association

Objective: Worsening renal function (WRF) is a frequent finding in patients with acute decompensated heart failure (ADHF) and is a powerful independent prognostic factor for adverse outcomes. The link between abdominal congestion and worsening renal function in such patients is not yet fully addressed. The aim of this study was to evaluate the role of abdominal congestion in the early prediction of worsening renal function in hospitalized patients with acute decompensated heart failure. Methods: This was a prospective study that enrolled 100 patients with a diagnosis of ADHF and received intravenous diuretic therapy. Intra-abdominal pressure (IAP), splenic Doppler impedance indices …

Tracking Population Decline In India Between 1950-2023 And Total Deaths Cases By Cause – A Case Study, Sumayya Rehaman Research Scientist

International Journal of Health and Allied Sciences

The Case study digs the facets of the India’s population decline from 1950-2023. Focusing Total fertility rate recorded 2.0 per woman in 2023 as similar as Birth Rate since 1950-2023 and found to be 16.9 births per 1000 people in 2023. Contradictorily, may surpass China’s population in Future. It focuses Population pyramid with annual Percent growth rate divulges Main cities population and exemplifies death occurrence. The median age - 28.7 years, life expectancy - 70.4 years, Infant Mortality Rate - 26.6 deaths per 1000 live births, with 3.89% in 2023.This study reveals comparative illustrative graphs of Indian Population 1950-2023.

Effectiveness Of Oil Pulling Using Coconut Oil And Sesame Oil In Comparison With 0.2% Chlorhexidine And Placebo In Plaque Reduction- A Randomized Control Trial’, Bharath Shivakumar, Sunitha S, Chandrashekar Br, Mirunalini Sundaravadivelu

International Journal of Health and Allied Sciences

Context: Oil pulling has multiple oral health benefits toward gingival and overall health. Aims: To evaluate the effectiveness of oil pulling using sesame and coconut oils. Settings and Design: JSS High School, Suttur, Nanjangud Taluk, Mysuru Randomised controlled double-blinded parallel-arm study. Methods and Material: Participants selected were divided into four groups randomly. Mouth rinse bottles containing coconut oil, sesame oil, chlorhexidine and placebo were coded and distributed. Follow up was done on the seventh day and fourteenth day. Results: The study groups showed statistically significant difference. Conclusions: Oil pulling is effective in oral plaque control.

Examining The Impact Of Internal Family Systems (Ifs) Theory Versus Emotionally Focused Individual Therapy (Efit) On Depression For College Students: A Comparative Study, Laura Anne Bowlin, Hillary Bucher-Brown

School of Psychology, Family, and Community Research Conference

In light of the prevalence of depression in modern society, researchers persist in the quest for effective treatment approaches. This research proposal aims to examine the impact of Internal Family Systems (IFS) Theory and Emotionally Focused Individual Therapy (EFIT) on depression among college students. The study will involve 20 college students recruited from local universities experiencing depression, as measured by the Beck Depression Inventory (BDI). Each participant will undergo ten psychotherapy sessions, randomly assigned to a certified IFS or EFIT therapist. Subsequently, participants will complete a post-test using the BDI. Comparative analysis of the outcomes between the two groups will …

Internal Family Systems And Codependency: Finding Self In Relationship With Another Person’S Addiction, Jillian Ostlund, Mandah Gombosuren

School of Psychology, Family, and Community Research Conference

Codependency is a concept that is currently not considered a disorder in the DSM-V, yet people have been identifying with the traits of codependency since the 1940's (Bacon et al., 2018). In IFS the concept of blending means Parts are not able to differentiate from one another, making it difficult to sense Self Leadership (Schwartz & Sweezy, 2020). The researchers for this proposal were not able to find literature on the treatment of codependency using IFS. It is believed that IFS can help a codependent person to gain access to Self and be able to recover from the effects of …