Medicine and Health Sciences Commons^™

Structure-Functional Prediction And Analysis Of Cancer Mutation Effects In Protein Kinases, Anshuman Dixit, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

A central goal of cancer research is to discover and characterize the functional effects of mutated genes that contribute to tumorigenesis. In this study, we provide a detailed structural classification and analysis of functional dynamics for members of protein kinase families that are known to harbor cancer mutations. We also present a systematic computational analysis that combines sequence and structure-based prediction models to characterize the effect of cancer mutations in protein kinases. We focus on the differential effects of activating point mutations that increase protein kinase activity and kinase-inactivating mutations that decrease activity. Mapping of cancer mutations onto the conformational …

Structure, Synthesis And Biological Activity Of Harmful Algal Bloom Toxins From Karlodinium Sp. And Exploration Of Microbial Derived Natural Products, Amanda Leigh Waters

Electronic Theses and Dissertations

This work features natural products isolated from both the marine and microbial environments. Part I focuses on the elucidation of toxins from harmful algal blooms (HAB). The HAB dinoflagellate Karlodinium veneficum produces a harmful suite of molecules identified as the karlotoxins (KmTx) that have been implicated in massive fish kills pan-globally. Nine new karlotoxin congeners were isolated from various Karlodinium blooms around the world and utilizing the structure of KmTx2 were characterized using overlaid 2D NMR techniques. Due to the contrasting conformational differences between KmTx and the closely related amphidinols, the absolute configuration of KmTx was further evaluated by extensive …

Shoulder Impingement In Water Polo Players, Kelly A. Davis

Scripps Senior Theses

Water polo is a highly dynamic and physically demanding sport that has heretofore not inspired nearly as much research as other overhead sports such as baseball or swimming. As in almost all overhead sports, water polo puts its players at high risks for shoulder injuries since the motions required to perform the sport at an optimum level push the limits of normal shoulder function.

Human shoulders are inherently unstable as a tradeoff to their flexibility. Because of this instability, many structures are required to work concurrently to keep the shoulder in place. These structures include muscles, ligaments and cartilages. It …

Shots, Everybody? : British Anti-Smallpox Vaccination And The Development Of Multifaceted Anti-Vaccine Rhetoric On Internet Parenting Forums, Marta B. Bean

Scripps Senior Theses

Vaccination is an important public health measure that can help reduce disease at the population level. Substantial evidence exists that vaccines are safe and effective at reducing the incidence of diseases like pertussis, measles and cervical cancer. However, on Internet parenting forums, parents discuss whether or not vaccination is the right choice for their children. In this thesis, I highlight the historical context of the anti-vaccine movement in mid 19^th century to early 20^th century Victorian Britain in the era of compulsory smallpox vaccination. Vaccination in this time was a very different and more overtly dangerous process, and …

Where Should Baby Sleep?: An Examination Of Discourse Regarding Bed Sharing In The United States, Kari Mcclure Mentzer

EWU Masters Thesis Collection

No abstract provided.

The Impact Of Oral Health On Quality Of Life In The Aging Population, Jana Mannen

EWU Masters Thesis Collection

Purpose: This study sought to bring awareness to the scientific community of the need for regular dental care in skilled nursing facilities (SNF) by proving access to oral care has an effect on oral health and may have an impact on the SNF residents’ daily performance and Quality of Life (QoL). Methods: This study was conducted at a private SNF in a southern metropolitan area with a sample size of 30 (N=30). The PI and two research assistants conducted interviews and oral exams using a modified 10 item Oral Impacts on Daily Performance (OIDP) with two free response (QoL) questions, …

Caffeine And Human Perception Of Time, Trevor Fry

EWU Masters Thesis Collection

The purpose of this study was to investigate the effect of caffeine on several components of time perception in an attention-demanding task. Review of the current literature shows that the rhythm of the brain's internal clock, controlled by the suprachiasmatic nucleus (SCN), which is believed to mediate the perception of short durations, is sensitive to a variety of stimuli including stimulants. This study expands on previous research on the effect of caffeine on prospective time estimation by having participants estimate multiple short durations while completing a cognitively complex time estimation task involving math. The study included a moderate dose caffeine …

The Effects Of A Compassion Focused Intervention On A Non-Clinical Student Population, Adrian Kunemund

EWU Masters Thesis Collection

Previous research has suggested that Compassion Focused Therapy (CFT) is beneficial for individuals suffering from a variety of mental health concerns including depression, shame, and self-criticism. The present study assessed the effects of a 10-week university Introduction to CFT course that includes a group orientation to CFT including exposure to CFT intervention exercises. It was hypothesized that those receiving the CFT course would show reductions in shame, self-criticism, and fears of compassion, and increases in gratitude, positive affect, and self-compassion relative to controls. While some differences were observed between the CFT and control groups, none of the hypothesized group X …

The Relationship Between Simple Pleasures And Trait Gratitude, Megan Shupe

EWU Masters Thesis Collection

Grateful disposition is associated with positive affect, happiness, high levels of overall well-being and an appreciation of simple pleasures. This study further examined the relationship between simple pleasures and trait gratitude. I hypothesized that people with higher trait gratitude scores would notice more simple pleasures in their lives and feel more gratitude for simple pleasures than less grateful people. I acquired data from 169 undergraduate students at Eastern Washington University. Results suggested that grateful people experienced the same number of simple pleasures as less grateful people but were more grateful for them. This suggests that although grateful people do not …

Examining Sexual Satisfaction And Pretending Orgasm, Chelsea Twiss

EWU Masters Thesis Collection

An article in popular women’s magazine, Cosmopolitan, recently revealed a startling admission from its readers: 86% of respondents reported pretending orgasm during intercourse with a partner (Kylstra, 2011). Despite its apparent frequency, there is yet to be a study conducted investigating the relationship between pretending orgasm and overall sexual satisfaction (Ippolito, 2012). Sexual satisfaction is linked with important facets of life such as overall relationship satisfaction and general wellbeing. The present study examines the relationship between experiencing orgasm, pretending orgasm and overall sexual satisfaction. Participants were Eastern Washington University college students recruited via an online survey website (Qualtrics), and who …

Transgenerational Transmission Of Trauma In Second Generation Latino Children And Adolescents, Ricardo Phipps

Electronic Theses and Dissertations

This study explored the impact that immigration-related trauma has upon families, particularly second-generation immigrant children in the Latino-American community in the United States, and the possibility that second-generation immigrant Latinos are vulnerable to transgenerational trauma. Transgenerational trauma involves the exhibition of posttraumatic stress disorder (PTSD) symptoms in subsequent generations in families with histories of trauma exposure. Multiple linear regression was conducted to explore the existence of a correlation between PTSD and depression in second-generation Latino immigrant children and adolescents with a myriad of potentially predicting factors. Enhanced understanding of how trauma can affect the children of traumatized immigrants will add …

Exploring New Approaches For Weight Loss Maintenance: Intuitive Eating And Emotional Brain Training, Joy Ann Vaught

Theses and Dissertations--Nutrition and Food Systems

While traditional behavioral weight loss programs have been successful at producing weight loss, weight maintenance is difficult to achieve. Addressing stress, one major contributing factor in weight gain, may be a potential solution. The purpose of this study was to test a stress-management program (EBT) for changes in weight and blood pressure, and maintenance of those changes. Obese adults (N=33) were randomized to two weight loss groups for a seven-week intervention and a seven-week follow-up period: an intuitive eating group or a stress management group. The intuitive eating group did not have any statistically significant changes in weight or blood …

Study Abroad Opportunities For Dietetics And Human Nutrition Students: Expectations, Benefits And Barriers, Kailey Marie Cunningham

Theses and Dissertations--Nutrition and Food Systems

This study analyzed the perceptions of University of Kentucky Dietetic and Human Nutrition students as they relate to the benefits and barriers of study abroad educational opportunities. The final sample consisted of 164 participants, with 18.9% (n=31) in the Coordinated Program in Dietetics (CP), 32.3% (n=53) in the Didactic Program in Dietetics (DPD), 42.7% (n=70) in the Human Nutrition (HN) program and 5.5% (n=9) who identified their program as ‘other’. The primary barriers to participation in study abroad were cost and problems fitting education abroad into the current program of study. The primary benefits were identified as dietary and health …

Role Of Viral And Host Factors In Influenza Virus Mediated Inhibition Of Interleukin-23, Ashish Tiwari

Theses and Dissertations--Veterinary Science

Influenza virus is one of the major respiratory pathogens of humans as well as animals, including equines. There is an increasing evidence that bacterial infections are the most common cause of the death during influenza. In horses also, secondary bacterial pneumonia can lead to death, and surviving horses may take up to six months for the complete recovery resulting in heavy economic loss to the equine industry. Interleukin (IL)-23 mediated innate immune response has been shown to protect the host from various respiratory bacterial infections. However, studies to investigate the role of host and viral factors in the regulation of …

Heritage Hog Carcass Yields: Gloucestershire Old Spots Hog, Bob Perry

Heritage Hog Carcass Yields

The saleable yield of a Gloucestershire Old Spot Hog, cut in the American style, is 71%. The overall percentage of lean muscle using the industry formula based on backfat at 1st and 10th rib, loin eye area and hot carcass weight is 46%. Cut for Charcuterie, the saleable yield is 71%, not including bones, trim and backfat.

Multimorbidity In A Marginalised, Street-Health Australian Population: A Retrospective Cohort Study, Tom Brett, Diane Arnold-Reed, Lakkina Troeung, Max Bulsara, Annalise Williams, Robert G. Moorhead

Medical Papers and Journal Articles

OBJECTIVES:

Demographic and presentation profile of patients using an innovative mobile outreach clinic compared with mainstream practice.

DESIGN:

Retrospective cohort study.

SETTING:

Primary care mobile street health clinic and mainstream practice in Western Australia.

PARTICIPANTS:

2587 street health and 4583 mainstream patients.

MAIN OUTCOME MEASURES:

Prevalence and patterns of chronic diseases in anatomical domains across the entire age spectrum of patients and disease severity burden using Cumulative Illness Rating Scale (CIRS).

RESULTS:

Multimorbidity (2+ CIRS domains) prevalence was significantly higher in the street health cohort (46.3%, 1199/2587) than age-sex-adjusted mainstream estimate (43.1%, 2000/4583), p=0.011. Multimorbidity prevalence was significantly higher in …

Cultural Conversations With Brazilian And Dominican Transnationals: Implications For Health And Wellbeing, Cristina Brinkerhoff, Carlos Eduardo Siqueira, Rosalyn Negrón, Amanda Reich, Linda Sprague Martinez

C. Eduardo Siqueira

This poster summarizes the results of several cultural conversations with Brazilian and Dominican immigrants in Massachusetts, held during 2014.

Instruction In Functional Assessment, Marcie Desrochers, Moira Fallon

Milne Open Textbooks

Instruction in Functional Assessment introduces learners to functional assessment (FA), which includes a variety of assessment approaches (indirect, observational, and experimental) for identifying the cause of an individual’s challenging behavior for the purpose of designing effective treatments. FA is mandated by federal law and is a recognized empirically based approach to treatment of individuals with challenging behaviors (e.g., disruptive, self-injurious, and aggressive behaviors). Instruction in FA is essential for students who will one day enter professions as educators, psychologists, social workers, counselors, or mental health professionals.

The purpose of this textbook is to provide instruction in FA skills for pre-professionals …

A Randomized Clinical Trial On The Effects Of Extracorporeal Shockwave Therapy, Joint Mobilizations And Exercise On Plantar Heel Pain In Patients With Plantar Fasciitis, Paolo Sanzo, Elizabeth Oakley

Faculty Publications

Plantar fasciitis (PF) is the most common cause of heel pain today impacting on the patient’s walking ability, work tolerance, and ability to participate in active sport. Two million people in the United States (US) are treated for PF yearly with heel pain accounting for 11 to 15% of visits to medical professionals. It is estimated that 10% of the US population will develop PF during their lifetime. Treatment for PF may include a variety of interventions ranging from conservative treatment to surgical interventions. One of the suggested treatments for PF is the use of extracorporeal shockwave therapy (ECSWT). ECSWT …

Growing Up With Hiv In Kisumu, Kenya: Participatory Action Research With Young People Living With Hiv, Zoe Alexis Hobbs Marinkovich

Doctoral Dissertations

Forty-one percent of new HIV infections are in young people between the ages of 15-24 (Masquillier, et al., 2012). In addition to new infections, advances in medications are now making it possible for children born with HIV to survive into adolescence and adulthood (Bland, 2011; Gray, 2010). Due to the growing population of youth living with HIV, there is an increased need for adolescent-appropriate care and intervention. While many studies have examined the role of education in preventing HIV transmission for HIV-negative youth in the Sub-Saharan context, few have focused on the education and experiences of young people living with …

First-Year Male Students' Adherence To Traditional Male Gender Roles And Their Attitudes Toward Bystander Approach Behaviors To Stop Sexual Assault, Kamal M. Harb

Doctoral Dissertations

Sexual assault on university campuses may affect any person at any time. However, university-aged women are disproportionally affected by it, with 25% of women reporting being assaulted on campus, and 84% to 97.8% of them perpetrated by young, heterosexual men known to the victim. To curb sexual assault on the university campus, research studies have advocated for the bystander approach. It encourages bystanders (observers) to intervene and ultimately stop a potentially dangerous situation in which a friend or stranger may experience a sexual assault. Despite its popularity, research studies evaluating the bystander approach have reported, at best, modest success with …

Exploring The Experiences Of Latina/Os In Graduate Health Science Programs: A Qualitative Study, Mijiza Malane Sanchez

Doctoral Dissertations

This qualitative study conducted at a Northern California university explored how six Latino/a health science professionals navigated their academic trajectory. The six participants identify as Latino/a and shared their journeys to the health sciences. This study examined how participants utilized their community cultural wealth to navigate the complexities of campus climate during their pursuit of a graduate or professional degree in the health sciences. Research data included narratives from in-depth interviews with the six participants and a focus group.

The key findings of this study illustrate the profound significance of mentorship in the pursuit of health science careers. This study …

Not Just Another Assignment: Partnering With Faculty To Assess Student Information Literacy Skills, Beth M. Transue

Library Staff Presentations & Publications

A teaching collaboration with an undergraduate nursing assignment. The librarian graded 114 assignments and then provided grades to classroom faculty.

57 nursing students,1 CINAHL Worksheet each,1 PubMed worksheet each

Data Note: Are Young Adults With Intellectual Disabilities Getting Work Experiences From Participating In The Vocational Rehabilitation Program?, Alberto Migliore, Jean Winsor

Data Note Series, Institute for Community Inclusion

To learn about whether young adults with intellectual disabilities in the vocational rehabilitation (VR) program are getting work experience, we examined the age at application of people with intellectual disabilities who exited the VR program in 2012.

Data Note: Vocational Rehabilitation Closure Trends For Individuals With Intellectual Disabilities: A Snapshot Of Five U.S. Territories, Jean Winsor, Daria Domin

Data Note Series, Institute for Community Inclusion

Beginning in FY2013, the Administration on Intellectual and Developmental Disabilities requested that each Project of National Significance include the five primary territories of the United States in data collection and analysis efforts. The five territories included in this analysis are American Samoa, Guam, Northern Marianas, Puerto Rico, and the Virgin Islands of the United States.

Massachusetts Healthy Aging Data Report: Community Profiles, Elizabeth Dugan, Frank Porell, Nina Silverstein, Ruth Palombo, Stacey Mann

Gerontology Institute Publications

The Massachusetts Healthy Aging Data Report: Community Profiles was created by researchers at the Gerontology Institute of the John W. McCormack Graduate School of Policy and Global Studies at the University of Massachusetts Boston and commissioned by the Tufts Health Plan Foundation.

In this report, we have created a custom profile of nearly 100 healthy aging indicators for every city and town in Massachusetts including the 16 neighborhoods of Boston (367 Community Profiles). Each Community Profile is designed to help community residents, agencies, providers, and governments understand the older adults who live in their cities and towns – their ages, …

Service Provider Promising Practice - Via Of The Lehigh Valley (Pennsylvania): Partnership With Local Schools To Provide Customized Employment, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Via of the Lehigh Valley is a CRP headquartered in Bethlehem, PA. Since 2008, Via and local high schools have provided customized employment services so that transition-age students graduate into well-matched, meaningful careers. Via’s transition program is supported by funds from the Pennsylvania Department of Education. The energy of students and their families has also driven the search for innovative employment services. Via’s work with schools began with hosting weekend trainings for families, sponsored by the Pennsylvania DD Council. Families learned systems navigation and advocacy skills, and followed up with special education directors at their children’s high schools to advocate …

Service Provider Promising Practice - Able Opportunities And The Work Independence Network (Washington): Creating An Individual Placement Model Focusing On The Needs Of Both Job Seekers And Employers, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Able Opportunities is a certified vendor for the state of Washington’s Department of Vocational Rehabilitation, Developmental Disabilities Administration, Division of Developmental Disability, and Department of Labor and Industry. The Work Independence Network (WIN) began in 2005 as a partnership between Able Opportunities, Harrison Medical Center, and Kitsap County Developmental Disabilities to help people with intellectual and developmental disabilities (IDD) find jobs. Through WIN, Able Opportunities strives to meet the needs of both job seekers and employers through the use of innovative business model tools, including cost-benefit analysis and production charts. WIN’s goal is to help people with disabilities find meaningful …

Crafting A Narrative For The Red State Option, Elizabeth Weeks Leonard

Scholarly Works

This Article examines the current state of play following the Supreme Court's decision in NFIB v. Sebelius to allow states the option of expanding their Medicaid programs in accordance with the Patient Protection and Affordable Care Act (ACA). Holding that mandatory expansion was unconstitutionally coercive, the Court created the Red State Option. Despite the enormously generous federal financial support for Medicaid expansion, close to half of the states have declined. At the same time, at least eight Republican-led states have crossed Tea Party lines to accept federal funding for expansion. Drawing lessons from these states, including Arkansas, Arizona, Michigan, and …

Detecting Knowledge Of Incidentally Acquired, Real-World Memories Using A P300-Based Concealed-Information Test, John B. Meixner Jr., J. Peter Rosenfeld

Scholarly Works

Autobiographical memory for events experienced during normal daily life has been studied at the group level, but no studies have yet examined the ability to detect recognition of incidentally acquired memories among individual subjects. We present the first such study here, which employed a concealed-information test in which subjects were shown words associated with activities they had experienced the previous day. Subjects wore a video-recording device for 4 hr on Day 1 and then returned to the laboratory on Day 2, where they were shown words relating to events recorded with the camera (probe items) and words of the same …