Medicine and Health Sciences Commons^™

The Effects Of Two Different Palatal Expanders On Nasal And Pharyngeal Airway Volumes As Measured By Cbct, Amira Allam, Tarek Marei, Fatma Abd Elsamad, Sayed Mekheimar

Al-Azhar Journal of Dentistry

Objective: To evaluate and compare the effect of memory palatal split screw (Memorax) to that of conventional Hyrax rapid palatal expanders on nasal and pharyngeal airway volumes, which were measured and recorded by Cone beam computed tomography (CBCT). Materials and Methods: This study was conducted over 14 subjects of adolescent patients with bilaterally constricted maxillary arches, the sample contained 12 females and 2 males, with age ranged from 12ys to 15ys, with a mean of 13.6 ± 1.4. The sample was divided into two age matched groups, the Memorax group(N=7) subjects with a mean age of 13.5 ± 0.4, received …

Effect Of Different Preparation Designs On The Fracture Load Of Two Machinable Laminate Veneers, Sara Tamimi, Eman Essam, Jylan El Guindy

Al-Azhar Journal of Dentistry

Aim: The present study was performed to evaluate the effect of different preparation designs [window, butt- Joint, and incisal overlap], on the fracture load of two CAD / CAM laminate veneer materials [Zirconia CAD / CAM and resinnanoceramic ; lava ultimate].Materials and Methods: Thirty maxillary anterior teeth were restored with ceramic laminate veneers and divided into 6 groups as follows: group I-A (laminates made of Ultra translucent zirconia CAD with window preparation design), group I-B (laminates made of Ultra translucent zirconia CAD with butt-joint preparation design), group I-C (laminates made of Ultra translucent zirconia CAD with incisal overlap preparation design), …

Protection From Aortic Aneurysm By Bmal1 Deletion From Smooth Muscle Cells, Jenny Lutshumba

Theses and Dissertations--Physiology

Abdominal aortic aneurysm (AAA) is a devastating condition that occurs primarily among older people with high mortality when a rupture occurs. Currently there is no proven pharmacological therapy for AAA due to poor understanding of the underlying pathogenesis. The brain and muscle transcription factor ARNT-like (Bmal1), which is known to regulate circadian rhythm, has been implicated in vascular pathologies including atherosclerosis and vascular remodeling, but its role in AAA has not been explored.

Vascular smooth muscle is a central player in aneurysm formation and development because it is critical in all three aortic aneurysm hallmark processes including (a) degradation of …

Sentinel Lymph Node Biopsy Pathology And 2-Year Postsurgical Recurrence Of Breast Cancer In Kenyan Women, Nathan R. Brand, Ronald Wasike, Khalid Makhdomi, Rajendra Chauhan, Zahir Moloo, Samuel Gakinya, Alfred I. Neugut, Jo Anne Zujewski, Shahin Sayed

General Surgery, East Africa

Purpose: The goal of this study was to describe the pathologic findings and early follow-up experience of patients who underwent a sentinel lymph node biopsy (SLNB) at Aga Khan University Hospital (AKUH) between 2008 and 2017.

Patients and Methods: We performed a retrospective analysis of women with breast cancer who underwent an SLNB at AKUH between 2008 and 2017. The SLNB was performed on patients with stage I and stage II breast cancer, and identification of the sentinel lymph node was made by radioactive tracer, blue dye, or both, per availability and surgeon preference. Demographic, surgical, and pathologic data, …

Campaña Del Lazo Blanco: Sesiones De Diálogo Para Su Promoción, Population Council

Poverty, Gender, and Youth

La Campaña de Lazo Blanco, promovida por UNFPA, se basa en el principio de incluir a los hombres como socios que promueven acciones comunitarias para incentivar la prevención de la violencia hacia la mujer. Esta guía para las sesiones de diálogo de la Campaña de Lazo Blanco en Guatemala fue desarrollada por el Population Council en el marco del Proyecto Interagencial de Prevención de la Violencia hacia las Mujeres. Este documento contiene herramientas para que participantes y facilitadores reflexionen sobre las formas de relacionamiento entre hombres y mujeres, identifiquen formas de violencia hacia las mujeres, y discutan sobre posibles soluciones …

Measuring Gender Equality In Education: Lessons From 43 Countries, Stephanie Psaki, Katharine Mccarthy, Barbara Mensch

Poverty, Gender, and Youth

Through the 2015 Sustainable Development Goals (SDG), governments committed to achieving universal secondary school completion, including eliminating gender disparities, by 2030. The period from 1997 to 2014 saw considerable progress in closing gender gaps in school enrollment and attainment in many, but not all, low- and middle-income countries. However, as this research brief explains, claims that gender parity in primary education now exists are premature, especially in the poorest countries and new gender gaps, or gender-related challenges, may emerge as attainment increases. Moreover, the extremely low levels of secondary school enrollment—and even moreso completion—demonstrate that the SDG target of universal …

A Glance Into How The Cold War And Governmental Loyalty Investigations Came To Affect A Leading U.S. Radiation Geneticist: Lewis J. Stadler’S Nightmare, Edward J. Calabrese

Environmental Health Sciences Faculty Publication Series

This paper describes an episode in the life of the prominent plant radiation geneticist, Lewis J. Stadler (1897–1954) during which he became a target of the Federal Bureau of Investigation (FBI) concerning loyalty to the United States due to possible associations with the communist party. The research is based on considerable private correspondence of Dr. Stadler, the FBI interrogatory questions and Dr. Stadler’s answers and letters of support for Dr. Stadler by leading scientists such as, Hermann J. Muller.

Sources And Content Of Popular Online Videos About Autism Spectrum Disorders, Betty Kollia, Margaret T. Kamowski-Shakibai, Corey H. Basch, Ashley Clark

Faculty Publications: Communication Sciences and Disorders

Background: Our study aimed to determine source of upload and content portrayed in the 100 most-viewed videos on autism spectrum disorders (ASDs) on the video sharing public forum, YouTube. ASDs have become highly prevalent in the last decade, arousing a significant response from the media and psycho-educational health professions. Utilization of and reliance on social media for information on health matters has also proliferated. Some suggest that online videos could promote early detection (and intervention) of ASD by prompting caregivers to seek guidance. However, the usefulness of the available videos is unclear. Methods: The 100 most popular YouTube videos were …

A Retrospective Review Of The After-Hours Social Work Service In A Tertiary-Care Public Hospital In Australia, Manoj Pereira, Georgina Wire, Kathy Stiller

Internet Journal of Allied Health Sciences and Practice

Purpose: After-hours social work (SW) services seem to be provided in many major healthcare centres but there appear to be no data describing these services, in terms of the number of patients seen, their characteristics, types of problems, SW interventions provided, their effectiveness or the impact of providing after-hours services on the provider. The aim of this study was to investigate the patient characteristics and types of interventions provided to patients who received an after-hours SW service and the effect of providing these services on the service-provider. Method: A retrospective review of data collected on patients who had received after-hours …

Influence That Service In A Pro Bono Clinic Has On A First Full-Time Physical Therapy Clinical Education Experience, Daria Porretta, Jill Black, Kerstin Palombaro, Ellen Erdman

Internet Journal of Allied Health Sciences and Practice

Purpose: Physical therapist education programs strive to prepare their students for full-time clinical experiences in a variety of ways. Experiential and service learning in authentic contexts reportedly help students make connections between the classroom and the clinic. The purpose of this study was to explore the influences that service in a physical therapy pro bono clinic has on a first full-time clinical education experience.

Methods: Participants were all third year doctoral physical therapy students at Widener University who were entering their first full-time clinical education experience. Sixteen participants kept journals throughout their first full-time clinical experience regarding the impact …

A Review Of The Use Of Massive Open Online Courses (Moocs) In Medical Imaging Education, Kevin R. Clark, Beth L. Vealé, Lynette K. Watts

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this review article is to describe the benefits and challenges associated with massive open online courses (MOOCs) and to discuss the implications specific to medical imaging education and training. Methods: Peer-reviewed journal articles pertaining to MOOCs in higher education were analyzed to identify commonalities, relationships, and possible gaps in the literature. Results: Analysis revealed several repetitive themes and concepts regarding the use of MOOCs in higher education: theory of connectivism, instructors’ and students’ perspectives, and benefits and challenges. Implications for medical imaging education and training were also discussed. Conclusions: As web-based education and technology integration continue …

Identification Of “Kratom” (Mitragyna Speciosa) Alkaloids In Commercially Available Products, Julia Grzymkowski, Michelle R. Peace, Justin Poklis

Undergraduate Research Posters

“Kratom” is the common name for the botanical mitragyna speciosa. It is a tree native to Southeast Asia in which leaves contain the psychoactive alkaloids mitragynine and 7-hydroxymitragynine. Kratom is often ingested as teas, chewed, or smoked. It acts as a stimulant in small doses and as an opioid in large doses. Overdoses can result in vomiting, seizures, and death. Recently the Drug Enforcement Agency (DEA) placed Kratom on Schedule 1, but, due to public outcry, it was almost immediately removed.

Eleven kratom based products were obtained from various tobacco shops, “headshops” and via the internet including: Choice brand …

Social Communication And Technology, Lesli G. Hughes

Murray State Theses and Dissertations

Research has been well documented as to the effects of screen time on mental health, physical health, cognitive development, and social development. However, little research exists as to the effects of screen time on the nonverbal aspects of communication, specifically eye gaze. In order to inform speech language pathologists when treating children with language and pragmatic disorders, this study examined the eye gaze of participants during physical play. Twenty-six participants from 5 to 8 years of age were recruited from a western Kentucky school. Results of eye gaze durations in participants were compared to screen time amounts in the home. …

Caregiver Training Program On Emergent Literacy Development Of Augmentative And Alternative Communication Users, Meghan Bowers

Murray State Theses and Dissertations

Teaching early literacy to typically developing individuals is widely practiced and has a vast amount of research backing its success (Strum et. al., 2006). Current research has shown that both children and adult augmentative and alternative (AAC) users are underachieving in the development of reading and spelling skills, but the underachievement in these areas is not correlated to a lack of cognitive and linguistic abilities (Sandberg, Smith, Larsson, 2010). Like their typically developing peers, AAC users must have the same repeated opportunities to participate in a wide range of literacy tasks to attain literacy skills (Strum et. al., 2006).

Children …

The Effects Of Reward-Based Training On The Behavioral Assessment Of The Domestic Dog, Shelby Vandergraff, Shelby K. Vandergraff

Murray State Theses and Dissertations

Contrary to popular belief, pet overpopulation is caused more by owners failing to keep their dog than with accidental or intentional breeding (Moulton et al., 1991). Factors related to relinquishment have been researched, and concluded that behavioral problems are the most reoccurring reasons observed (Bailey, 1992; Miller at al., 1996; Patronek et al., 1996; Serpell, 1966; Salman et al., 1998, 2000; Scarlett et al, 1999; New et al., 2000; Shore et al., 2003, 2005; Mondelli 2004, Blackwell et al., 2008). When animals are relinquished to the shelter, the likelihood of the animal being euthanized increases. The purpose of this research …

Breed Quality Scores For Post-Cervical Artificial Insemination And The Effects On Farrowing Rate And Total Born At A Commercial Swine Facility In The Southern United States, Kathryn R. Prus

Murray State Theses and Dissertations

The objective of this experiment was to determine the possible relationship between a sow’s ease of breeding on the first service and the farrowing rate and total born. This study was conducted in a commercial farrowing unit in the Southern United States utilizing pen gestation with stock of 6,000 head. Five hundred ninety-seven sows were bred between the months of April and May 2017 were selected for this study. All animals were inseminated using a post-cervical artificial insemination catheter unless insertion of the inner catheter was impossible. The semen dose fell within the following parameters: concentration of 1.5 x 10 …

Master's Project: Burlington Geographic: A Place-Based Landscape Analysis And Community Engagement Project In Burlington, Vt, Sean R. Beckett

Rubenstein School Masters Project Publications

Community health surges when inhabitants share a rich sense of place, a quality emerging when people are deeply engaged in understanding their complex and layered landscape. Wendell Berry advises, “if you don’t know where you are, you don’t know who you are.” But how does a city converge around a collective “where” that authentically represents its diverse stories and perspectives? Answers to this question become tools for growing sustainable communities.

As a program coordinator for the UVM/Shelburne Farms PLACE (Place-based Landscape Analysis and Community Engagement) Program, I orchestrated a city-wide celebration of integrated natural and cultural history called Burlington …

The Social Income Inequality, Social Integration And Health Status Of Internal Migrants In China, Yanwei Lin, Qi Zhang, Wen Chen, Li Ling

Community & Environmental Health Faculty Publications

Background: To examine the interaction between social income inequality, social integration, and health status among internal migrants (IMs) who migrate between regions in China.

Methods: We used the data from the 2014 Internal Migrant Dynamic Monitoring Survey in China, which sampled 15,999 IMs in eight cities in China. The Gini coefficient at the city level was calculated to measure social income inequality and was categorized into low (0.2 < Gini <= 0.3), medium (0.3 < Gini <= 0.4), high (0.4 < x < = 0.5), and very high (Gini > 0.5). Health status was measured based upon self-reported health, subjective well-being, and perceptions of stress and mental health. Social integration was measured from four perspectives (acculturation and integration willingness, social insurance, economy, …

Food Safety Traceability, Yimin Wei, Boli Guo, Hongyan Liu, Shuai Wei, Jianrong Zhang

Food and Drug Administration Papers

With globalized economics, it is becoming more frequent to trade food across country and regional borders, which leads to expanding and spreading of all kinds of food safety incidents and hazards. Mad cow disease, foot and mouth disease, avian flu and other zoonotic diseases pose a grave threat to food safety and human health, causing serious economic losses for food industries and causing social panic at the same time. In order to reduce the losses caused by such serious zoonotic diseases, as well as to ensure food safety, many countries have started to implement food safety traceability systems. The European …

Quality By Design: Process Trajectory Development For A Dynamic Pharmaceutical Coprecipitation Process Based On An Integrated Real‐Time Process Monitoring Strategy, Huiquan Wu, Mansoor A. Khan

Food and Drug Administration Papers

Increasing prevalence of poorly water‐soluble drugs in pharmaceutical development provides notable risks of new products demonstrating low and erratic bioavailability. This dissolution‐limited bioavailability may have consequences for safety and efficacy, particularly for drugs delivered by the oral route of administration. Several novel drug delivery technologies have been developed to improve drug solubility, dissolution rates, and bioavailability. Among those are solid dispersion, nanotechnology, supercritical fluid technology, lipid‐based technology, and crystal engineering. Although these strategies are available for enhancing the bioavailability of drugs with low aqueous solubility, the success of these approaches is not yet guaranteed and is greatly dependent on the …

Microbial Ecology Of Fresh Vegetables, J. Zheng, A. De Jesus, S. Sahu, A. E. Hayford, Y. Luo, A. R. Datta, E. W. Brown, R. Bell

Food and Drug Administration Papers

The total consumption of fresh and processed vegetables has exceeded 123 kg per capita in the United States and 118 kg per capita in the European Union (http://www.helgilibrary.com/ indicators/index/vegetable‐consumption‐percapita) in 2009. Changes in lifestyles and consumption trends have prompted the sustained growth of fresh‐cut or minimally processed vegetables that are fresh and ready‐to‐eat (RTE). In 2011, for example, total US fresh‐cut produce sales through both food service and retail channels were estimated to surpass $27 billion (Cook et al., 2012).

Salmonella Inactivation During Extrusion Of An Oat Flour Model Food, Nathan M. Anderson, Susanne E. Keller, Niharika Mishra, Shannon Pickens, Dana Gradl, Tim Hartter, Galen Rokey, Christopher Dohl, Brian Plattner, Stuart Chirtel, Elizabeth M. Grasso-Kelley

Food and Drug Administration Papers

Little research exists on Salmonella inactivation during extrusion processing, yet many outbreaks associated with low water activity foods since 2006 were linked to extruded foods. The aim of this research was to study Salmonella inactivation during extrusion of a model cereal product. Oat flour was inoculated with Salmonella enterica serovar Agona, an outbreak strain isolated from puffed cereals, and processed using a single-screw extruder at a feed rate of 75 kg/h and a screw speed of 500 rpm. Extrudate samples were collected from the barrel outlet in sterile bags and immediately cooled in an ice–water bath. Populations were determined using …

An Overview Of The Role Of Mathematical Models In Implementation Of Quality By Design Paradigm For Drug Development And Manufacture, Sharmista Chatterjee, Christine M.V. Moore, Moheb M. Nasr

Food and Drug Administration Papers

A model is a representation of an underlying physical–chemical phenomenon. In the pharmaceutical industry, mathematical‐based models can be applied at all stages of development, starting with formulation design, continuing through process development and scale‐up, and extending into process monitoring and control of the commercial process. Implementation of models offers many benefits. These include, but are not limited to, (i) enhanced process understanding, (ii) reduction of experimentation cost, and (iii) improvement of productivity and product quality.

Models can be broadly categorized as either qualitative or quantitative. The focus of this chapter is quantitative models. These can be classified into three broad …

Modeling And Statistical Issues Related To Salmonella In Low Water Activity Foods, Sofia M. Santillana Farakos, Michelle Danyluk, Donald Schaffner, Régis Pouillot, Linda J. Harris, Bradley P. Marks

Food and Drug Administration Papers

The presence and survival of Salmonella in low water activity (a_w) foods continues to pose a challenge for the food industry. Peer‐reviewed literature data on prevalence and levels of contamination of Salmonella in low water activity foods in the United States are limited. Available published data include those on: Salmonella contamination on nuts and peanuts (Calhoun et al., 2013), almonds (Danyluk et al., 2007; Bansal et al., 2010), pecans (Brar, Strawn, and Danyluk, 2016), and walnuts (Davidson et al., 2015); prevalence and levels of Salmonella on spices (Van Doren et al., 2013); as …

The Mechanism Of Cirp In Inhibition Of Keratinocytes Growth Arrest And Apoptosis Following Low Dose Uvb Radiation, Yi Liao, Jianguo Feng, Yi Zhang, Liling Tang, Shiyong Wu

Food and Drug Administration Papers

UV induces CIRP expression and subsequent Stat3 activation, but the biological function and mechanism of CIRP and Stat3 in mediating UVB-induced skin carcinogenesis have not been fully elucidated. In this study, we demonstrate that CIRP is elevated in all tested melanoma and non-melanoma skin cancer cell lines; and the expression of CIRP is upregulated in keratinocytes after being irradiated with relatively low dose (<5 mJ/cm²), but not high dose (50 mJ/cm²), UVB acutely and chronically. The increased expression of CIRP, either induced by UVB or through overexpression, leads to resistance of keratinocytes to UVB-induced growth arrest and …

High Throughput Quantification Of Apolipoproteins A-I And B-100 By Isotope Dilution Ms Targeting Fast Trypsin Releasable Peptides Without Reduction And Alkylation, Bryan A. Parks, David M. Schieltz, Michael L. Andrews, Michael S. Gardner, John C. Rees, Christopher A. Toth, Jeffrey I. Jones, Lisa G. Mcwilliams, Zsuzsanna Kuklenyik, James L. Pirkle, John R. Barr

Food and Drug Administration Papers

Purpose: Apolipoprotein A-I (ApoA-I) and apolipoprotein B-100 (ApoB-100) are amphipathic proteins that are strong predictors of cardiovascular disease risk. The traceable calibration of apolipoprotein assays is a persistent challenge, especially for ApoB-100, which cannot be solubilized in purified form.

Experimental design: A simultaneous quantitation method for ApoA-I and ApoB-100 was developed using tryptic digestion without predigestion reduction and alkylation, followed by LC separation coupled with isotope dilution MS analysis. The accuracy of the method was assured by selecting structurally exposed signature peptides, optimal choice of detergent, protein: enzyme ratio, and incubation time. Peptide calibrators were value assigned by isobaric tagging …

Cyclosporine Exacerbates Ketamine Toxicity In Zebrafish: Mechanistic Studies On Drug–Drug Interaction, Bonnie L. Robinson, Melanie Dumas, Syed F. Ali, Merle G. Paule, Qiang Gu, Jyotshna Kanungo

Food and Drug Administration Papers

Cyclosporine A (CsA) is an immunosuppressive drug commonly used in organ transplant patients to prevent allograft rejections. Ketamine is a pediatric anesthetic that noncompetitively inhibits the calcium-permeable N-methyl-D-aspartic acid receptors. Adverse drug–drug interaction effects between ketamine and CsA have been reported in mammals and humans. However, the mechanism of such drug–drug interaction is unclear. We have previously reported adverse effects of combination drugs, such as verapamil/ketamine and shown the mechanism through intervention by other drugs in zebrafish embryos. Here, we show that ketamine and CsA in combination produce developmental toxicity even leading to lethality in zebrafish larvae when exposure began …

Rapid Testing Of Food Matrices For Bacillus Cereus Enterotoxins, Sandra M. Tallent, Jennifer M. Hait, Ann M. Knolhoff, Reginald W. Bennett, Thomas S. Hammack, Timothy R. Croley

Food and Drug Administration Papers

Nine different food products frequently associated with Bacillus cereus outbreaks were chosen as representative matrices to be evaluated with end-point polymerase chain reaction (PCR), enzyme linked immunosorbent assay, lateral flow device and mass spectrometry for detection of enterotoxins associated with human illness. Testing was performed on food portions inoculated with a bacterial strain and incubated at 30C for either 5 h or 24 h. A screening end-point multiplex PCR targeting enterotoxin genes including the emetic toxin and three diarrheal toxins, hemolytic hemolysin BL (Hbl), nonhemoltyic enterotoxin (Nhe), and cytolysin K. Commercially available kits were used to determine the presence/absence of …

Neurosurgery Concepts: Key Perspectives On Imaging Characteristics Of Spinal Metastases, Surgery For Low Back Pain, Anesthesia For Disc Surgery, And Laminectomy Versus Laminectomy And Fusion For Lumbar Spondylolisthesis., Carlito Lagman, Lawrance K Chung, Luke Macyszyn, Winward Choy, Zachary A Smith, Nader S Dahdaleh, Angela M Bohnen, Jin M Cho, Chaim B Colen, Edward Duckworth, Anand V Germanwala, Peter Kan, Alexander A Khalessi, Chae-Yong Kim, Sandi Lam, Gordon Li, Michael Lim, Jonathan H Sherman, Vincent Y Wang, Gabriel Zada, Isaac Yang

Neurological Surgery Faculty Publications

No abstract provided.

Proteoglycan Neofunctions: Regulation Of Inflammation And Autophagy In Cancer Biology., Liliana Schaefer, Claudia Tredup, Maria A. Gubbiotti, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview, we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes. We will critically discuss the dual role of proteoglycan-driven inflammation and autophagy in tumor biology, and delineate the potential mechanisms through which …