Medicine and Health Sciences Commons^™

Short-Term Bilateral Adrenalectomy: Biochemical And Morphological Alterations In The Rat Hippocampus, Ahlam Said Abi Issa

Theses

Several studies showed the effects of glucocorticoid hormones on the hippocampus. It has been reported that the chronic administration of high dose glucocorticoids (GC) results in the degeneration of pyramidal neurons. However, bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively, there are few publications on the effects of short-term bilateral adrenalectomy (ADX). We aimed to investigate the effects of ADX on levels of pro-inflammatory cytokines interleukin-1β (IL-1β), interkeukin-6 (IL-6) and tumor necrosis factor-α (TNF-α); levels of growth factors, response of microglia and astrocytes to neuronal death, and oxidative …

Sleep Disorders And Kidney Transplant Outcomes: Findings From An 18-Year (1997-2015) Historical Cohort Study, Margaret M. Lubas

Health Services Research Dissertations

A historic cohort study of kidney transplant recipients with a failed graft was conducted to examine the associations between sleep disorders and kidney transplant outcomes. Adult kidney transplant recipients who were transplanted and failed or died with a functioning graft during the designated study time period (January 1, 1997 to September 1, 2015, inclusive) were included (n=299). The primary independent variables, any sleep disorder and any sleep-disordered breathing disorders, were defined through a diagnosis in a subject’s medical record. Transplant outcomes included: death with a functioning graft, graft survival time, and patient survival time after graft failure.

Chi-square statistics were …

Natural History Of Gutter-Related Type Ia Endoleaks After Snorkel/Chimney Endovascular Aneurysm Repair., Brant W Ullery, Kenneth Tran, Nathan K Itoga, Ronald L Dalman, Jason T Lee

Articles, Abstracts, and Reports

OBJECTIVE: Alternative endovascular strategies using parallel or snorkel/chimney (chimney endovascular aneurysm repair [ch-EVAR]) techniques have been developed to address the lack of widespread availability and manufacturing limitations with branched/fenestrated aortic devices for the treatment of complex abdominal aortic aneurysms. Despite high technical success and midterm patency of snorkel stent configurations, concerns remain regarding the perceived increased incidence of early gutter-related type Ia endoleaks. We aimed to evaluate the incidence and natural history of gutter-related type Ia endoleaks following ch-EVAR.

METHODS: Review of medical records and available imaging studies, including completion angiography and serial computed tomographic angiography, was performed for all …

Genetic Association Analysis Of Polymorphisms In Psd3 Gene With Obesity, Type 2 Diabetes, And Hdl Cholesterol, Shaoqing Gong, Chun Xu, Liang Wang, Ying Liu, Daniel Owusu, Beth A. Bailey, Yujing Li, Kesheng Wang

Health & Biomedical Sciences Faculty Publications and Presentations

Highlights

• First study of PSD3 gene with obesity, type 2 diabetes and HDL cholesterol.

• Identified 23 SNPs associated with obesity with p < 0.05 in gene discovery.

• 20 SNPs were associated with obesity in meta-analysis of two samples.

• 6 SNPs associated with type 2 diabetes and 11 associated with HDL.

• Findings offer new insights into the pathogenesis of obesity and diabetes.

Abstract

Background

The pleckstrin and Sec7 domain-containing 3 (PSD3) gene has been linked to immune diseases. We examined whether the genetic variants within the PSD3 gene are associated with obesity, type 2 diabetes (T2D), and high-density lipoprotein (HDL) cholesterol level.

Methods

Multiple …

A Rare Case Of Vascular Ring And Coarctation Of The Aorta In Association With Charge Syndrome., Jonathan B. Wagner, Joshua Q. Knowlton, Peter Pastuszko, Sanket Shah

Manuscripts, Articles, Book Chapters and Other Papers

A male neonate presented with CHARGE syndrome, a multiorgan genetic disorder involving the Coloboma of the eyes, congenital Heart defects, nasal choanal Atresia, growth and development Retardation, Genitourinary disorders, and Ear anomalies and deafness. Moreover, he had a rare case of vascular ring-consisting of a right aortic arch with retroesophageal brachiocephalic artery-combined with coarctation of the mid-aortic arch. He underwent both vascular ring and aortic arch repair at our institution. To our knowledge, this is the 4th documented case of this exceedingly rare type of aortic arch anomaly combined with aortic arch obstruction. Moreover, it is the first confirmed case …

Building Research Infrastructure In Magnet® Hospitals: Current Status And Future Directions, Meg Johantgen, Marianne Weiss, Vicki Lundmark, Robin Newhouse, Karen Haller, Lynn Unruh, Maria Shirey

College of Nursing Faculty Research and Publications

OBJECTIVE: The aim of this study was to describe the infrastructures supporting research in Magnet® hospitals.

BACKGROUND: Hospitals undertaking the journey toward Magnet designation must build research and evidence-based practice (EBP) infrastructures that support the infusion of research and EBP into clinical practice.

METHODS: An electronic survey was developed and distributed to the chief nursing officer or Magnet coordinator of all Magnet hospitals between June 10, 2015, and July 8, 2015.

RESULTS: Of the 418 Magnet hospitals invited, 249 responses (60%) were received. Resources dedicated to nursing research were difficult to isolate from those for EBP. Supporting clinical nurses’ time …

Premedical Programs Newsletter, April-May 2017, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs.

Oligodendrocyte Nf1 Controls Aberrant Notch Activation And Regulates Myelin Structure And Behavior, Alejandro Lopez-Juarez, Haley E. Titus, Sadiq H. Silbak, Joshua W. Pressler, Tilat A. Rizvi, Madeleine Bogard, Michael R. Bennett, Georgianne Ciraolo, Michael T. Williams, Charles V. Vorhees, Nancy Ratner

Health & Biomedical Sciences Faculty Publications and Presentations

The RASopathy neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic disorders. In NF1 patients, neurological issues may result from damaged myelin, and mice with a neurofibromin gene (Nf1) mutation show white matter (WM) defects including myelin decompaction. Using mouse genetics, we find that altered Nf1 gene-dose in mature oligodendrocytes results in progressive myelin defects and behavioral abnormalities mediated by aberrant Notch activation. Blocking Notch, upstream mitogen-activated protein kinase (MAPK), or nitric oxide signaling rescues myelin defects in hemizygous Nf1 mutants, and pharmacological gamma secretase inhibition rescues aberrant behavior with no effects in wild-type …

Critical Analysis Of Breastfeeding Education Provided In The Hospital, Abigail Sweet

Senior Honors Projects

The World Health Organization (W.H.O) recommends exclusive breastfeeding for the first six months of an infant’s life. A large majority of new mothers are making the decision to breastfeed their newborn child. According to the Centers for Disease Control and Prevention, as of 2016, high breastfeeding initiation rates show that most mothers in the U.S. want to breastfeed and are trying to do so. However, there are several indicators that suggest that mothers may not be getting the support they need and the early postpartum period is a critical time for establishing support for breastfeeding. Depending on the type of …

Flexible Dieting And Metabolic Adaptation During Weight Loss: A Comprehensive Review, Bryce Lahaie

Senior Honors Projects

Flexible dieting is a ubiquitous method of eating among the fitness population. It is not a diet, but rather a nutritional concept that refutes any diet that promotes cutting out entire foods or food groups as a method to lose weight. It is a structured and science-based method of eating that involves tracking calories through monitoring the three main macronutrients: carbohydrates, fats, and proteins. These macronutrients are individualized and adjusted for muscle growth, fat loss, or weight maintenance in order to optimize intake to facilitate the manipulation of body composition. Flexible dieting is a disciplined method of eating that teaches …

Maternal Estrogen Exposure May Be Linked To An Increased Risk Of Autism Spectrum Disorder, Sarah Bunker

Senior Theses and Projects

The current study explored the possibility that maternal estrogen dominance serves as a risk factor for having a child with autism. An online survey was sent to both biological mothers of autistic children (n=253) and biological mothers of non-autistic children (n=221). The survey presented a series of questions pertaining to both endogenous and exogenous factors and exposures that could increase estrogen levels. The data on exogenous exposures is treated in another paper (Helt, Bocobo, Bunker, & Lasky, in progress). The current paper presents the findings on exogenous maternal estrogen exposure and autism risk (e.g., previous history of trauma, stress, diet, …

Ua12/2/2 2017 Talisman: Well Being, Wku Student Affairs

WKU Archives Records

2017 Talisman yearbook.

• Kaetzel, Kylee. Editor’s Note
• Upton, Jordan. His Hands
• Watkins, Abby. The Meal Plan – Recipes
• Eastham, Lillie. New Hieghts – Reed Mattison, Rock Climbing
• Robb, Hayley. A Life Transformed – Annabeth Welborn
• Robb, Hayley. 6:00 AM Bright & Early – Exercise
• Doyel, Rachael. Redifining Ability – Jacob Holt
• Upton, Jordan. Yom Kippur at Happy Hills Buddhist Temple
• Wegert, Sally. Inner Peace – Allison Adams, Yoga
• Mattingly, Evan. The Future’s in Your Hands – Bianca Williams, Psychics
• Frint, Hunter. Too Often Silenced – Unity Walk
• Doyel, Rachael. Changing Tides
• Wells, Spencer. Struggle & Rebirth – Trey Farlee, Musicians …

Interview With Melinda Perrin, Melinda H. Perrin

Texas Medical Center - Women's History Project

An oral history interview with Melinda Perrin about her career in the Texas Medical Center and work on the board of Hermann Hospital and later Memorial Hermann Healthcare System.

Melinda Hill Perrin was born into a family known for the leadership it has provided both the city of Houston and the state of Texas. Her father John Hill served as the Texas’ secretary of state, then attorney general and finally Chief Justice of the state Supreme Court. Her work in the community and the non-profit sector led to her selection as a member of the Board of Hermann Hospital during …

Interview With Margaret Carter Mcneese, Margaret Carter Mcneese M.D.

Texas Medical Center - Women's History Project

An oral history interview with Margaret Carter McNeese about her career in the Department of Pediatrics at the Univeristy of Texas Health Science Center at Houston Medical School.

Dr. McNeese’s undergraduate years were spent at Mary Baldwin College in Staunton, Virginia. She went to medical school at The University of Texas Medical Branch at Galveston, where she began her career as a physician and pediatrician. She has been a recipient of many awards, among them the UT Health Science Center at Houston’s President’s Award for Mentoring Women; the Catholic Charity Guild Award for service at the San Jose Clinic, the …

Interview With Diana Chow, Diana Shu-Lian Chow Ph.D.

Texas Medical Center - Women's History Project

Diana Shu-Lian Chow, Ph.D., is an outstanding researcher at the University of Houston College of Pharmacy, where she began her career in 1981. She has authored or co-authored more than 50 peer-reviewed journal articles, three book chapters and more than 200 abstracts presented at national and international scientific conference or meetings. She is the editor of the British Journal of Pharmacology, editorial board member for the Journal of Drug Development and Industrial Pharmacy and a reviewer for more than a dozen journals.

She holds more than 10 U.S. and international patents, and in 2009, the Houston Intellectual Property Law Association …

Interview With Kathryn Peek, Kathryn Elaine Peek Ph.D.

Texas Medical Center - Women's History Project

An oral history interview with Kathryn Elaine Hickman Peek about her career as a biomedical administrator and educator at many institutions in the Texas Medical Center.

Kathryn Elaine Peek, Ph.D. completed her bachelor’s degree in English and embarked on a first career as a public school teacher. She obtained master’s degrees in biology and behavioral sciences at the University of Houston and UH Clear Lake during two stays in the Houston area. She entered the University of Texas Graduate School of Biomedical Sciences at what is now the McGovern Medical School at the age of 39. She graduated with a …

Teaching Assistant [Career Paper], Madelynn Williams

Undergraduate Research Award

No abstract provided.

Cross-Sectional Analysis Of Cortical Thickness Across The Lifespan, Thomas J. Hum-Hyder

Senior Theses and Projects

An understanding of the normal aging process across the lifespan is important for gaining an understanding the pathophysiological changes that occur in accelerated aging diseases, such as Alzheimer’s Disease Dementia (ADD) and Vascular Dementia (VaD). The present study cross-sectionally analyzed cortical thickness values derived from T1-weighted magnetic resonance images for two large cohorts: Human Connectome Project and the Mayo Clinic Study of Aging. The 897 participants aged between 22-36 from the Human Connectome Project and the 801 participants aged between 52-92 from the Mayo Clinic Study of Aging created a robust cohort of non-demented individuals across the lifespan. We found …

A Second Chance: Employers’ Perspectives In Hiring Individuals In Addiction Recovery, Alicia B. Becton, Roy K. Chen, Teresia M. Paul

School of Rehabilitation Services & Counseling Faculty Publications and Presentations

There is a constant debate that employers are not adequately prepared to hire individuals in addiction recovery for a number of reasons. Literature suggests lack of awareness, knowledge, and skills necessary to interact with individuals in addiction recovery as common factors impacting employment outcomes. The purpose of the study was to use open-ended questions to examine employer perspectives toward hiring individuals in addiction recovery. Furthermore, the authors examined gender, business industry, and employer profession to identify any common factors between groups. Major themes in the study included employability, available supports and resources for business owners, influence of societal biases, and …

Oncolog, Volume 62, Number 04, April 2017, Bryan Tutt, Sarah Bronson

OncoLog MD Anderson's Report to Physicians (All issues)

• Advances in Surgical Management of Lymphedema: New options reduce edema in limbs, improve quality of life for cancer patients with lymphedema.
• Noncytotoxic First-Line Therapy for Mantle Cell Lymphoma: First-line therapy with targeted and immunotherapy agents produces high response rates in mantle cell lymphoma.
• Reports from the Survivorship Research Symposium: Research on BK virus, heart failure, and aspiration in cancer survivors.
• HOUSE CALL: Types of Immunotherapy for Cancer: Understanding different approaches to immunotherapy

The Safety Of Appropriate Use Of Over-The-Counter Proton Pump Inhibitors: An Evidence-Based Review And Delphi Consensus, David A Johnson, Philip O Katz, David Armstrong, Henry Cohen, Brendan C Delaney, Colin W Howden, Peter Katelaris, Radu I Tutuian, Donald O Castell

Journal Articles

The availability of over-the-counter (OTC) proton pump inhibitors (PPIs) for the short-term (2 weeks) management of frequent heartburn (≥2 days/week) has increased markedly, yet evidence-based recommendations have not been developed. A panel of nine international experts in gastroesophageal reflux disease developed consensus statements regarding the risks and benefits of OTC PPIs using a modified Delphi process. Consensus (based on ≥80% approval) was reached through multiple rounds of remote voting and a final round of live voting. To identify relevant data, the available literature was searched and summarized. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system terminology was used to …

Outcomes Of Internal Hemipelvectomy For Pelvic Tumors: A Developing Country’S Prospective, Masood Umer, Rizwan Haroon Rashid, Yasir Mohib, Haroon Rashid

Department of Surgery

Introduction: Previously, external hemipelvectomy was the mainstay of treatment for pelvic tumors. However, with technological advancements, limb salvage procedures such as internal hemipelvectomy have emerged as a viable alternative. However, there is limited literature available on long-term outcomes and complications of internal hemipelvectomy, especially from developing countries. Therefore, the objective of this study was to share our experience of internal hemipelvectomy at a tertiary care center in a developing country. Materials and methods: A retrospective review was conducted in which all 24 patients undergoing internal hemipelvectomy from January 1, 2005 to December 31, 2015 at our institution were included. Medical …

Giant Haemangioma Of Nasopharynx: A Rare Case Outcome., Haissan Iftikhar, Moghira Siddiqui

Department of Surgery

Abstract

A 60-year-old female presented to us with a 5-year history of progressive right sided nasal obstruction and recurrent epistaxis. On examination lesion was seen in the right nostril which was firm and bled on probing. CT-scan paranasal sinuses showed a right sided lesion of nose and naso-pharnyx obstructing posterior nasal choanae. Dimensions were reported to be 9×4.1×3.8 cm. A punch biopsy was taken in operating room under general anaesthesia which resulted in profuse bleeding. Suction cautery was used to control bleeding and the nose was packed. The mass was firm to hard and provided resistance during the time of …

Oliver Sacks And The Neurology Of The Self, Sam Martin

Student Writing

No abstract provided.

Enterobius Vermicularis In Tubo-Ovarian Abscess: A Rare And Interesting Incidental Finding - A Case Report, Faryal Saleem, Faizan Malik, Saira Fatima

Department of Pathology and Laboratory Medicine

Enterobius vermicularis is a common intestinal nematode; however, rare extraintestinal Enterobius infections have been reported from different parts of the world. Here, we present a case of tubo-ovarian abscess in an otherwise healthy young sexually active female with no known comorbids with history of on and off lower abdominal pain for one year and high grade fever for one month. On the basis of further workup and radiological evaluation, a preoperative diagnosis of right sided tubo-ovarian abscess was made and salpingo-oophorectomy was performed laproscopically in July 2015. Histopathology of the resected tissue revealed necrosis and in one area Enterobius vermicularis …

Curcumin And Turmeric Modulate The Tumor-Promoting Effects Of Iron In Vitro., Donald J Messner, Todd Robinson, Kris V Kowdley

Articles, Abstracts, and Reports

Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC

Perioperative Vision Loss In Cervical Spinal Surgery., Brandon C Gabel, Arthur Lam, Jens R Chapman, Rod J Oskouian, Ahmad Nassr, Bradford L Currier, Arjun S Sebastian, Paul M Arnold, Steven Hamilton, Michael G Fehlings, Thomas E Mroz, K Daniel Riew

Articles, Abstracts, and Reports

STUDY DESIGN: Retrospective multicenter case series.

OBJECTIVE: To assess the rate of perioperative vision loss following cervical spinal surgery.

METHODS: Medical records for 17 625 patients from 21 high-volume surgical centers from the AOSpine North America Clinical Research Network who received cervical spine surgery (levels from C2 to C7) between January 1, 2005, and December 31, 2011, inclusive, were reviewed to identify occurrences of vision loss following surgery.

RESULTS: Of the 17 625 patients in the registry, there were 13 946 patients assessed for the complication of blindness. There were 9591 cases that involved only anterior surgical approaches; the remaining …

Social Networks As Predictors Of Colorectal Cancer Screening In African Americans, Ernest Alema-Mensah, Selina A. Smith, Mechelle Claridy, Victor Ede, Benjamin Ansa, Daniel S. Blumenthal

Journal of the Georgia Public Health Association

Background: Early detection can reduce colorectal cancer (CRC) mortality by 15%–33%, and screening is widely recommended for average-risk adults beginning at age 50 years. Colorectal cancer mortality rates are higher in African Americans than in whites, while screening rates are somewhat lower. Individual social networks can reduce emotional and/or logistical barriers to healthpromoting but distasteful procedures such as CRC screening. The aim of this study was to examine social network interactions, and their impact on CRC screening among African Americans. We hypothesized a positive association between social network index (SNI) scores and CRC screening.

Methods: In a community intervention trial …

Recognizing And Addressing The Oral Health Needs Of Georgia, Carole Hanes, Ketarya Hunt, Stephanie Perry

Journal of the Georgia Public Health Association

Background: The intent of this report is to provide an assessment of oral health needs for Georgia and to highlight the efforts underway at the Dental College of Georgia (DCG) at Augusta University to address these needs. In underserved areas of Georgia, the burden of untreated oral disease remains high. Because of in-migration and the inadequate availability of educational programs, the population continues to grow faster than the number of health care providers.

Methods: An overview of the oral health needs in Georgia is provided, along with a review of the ongoing outreach by the DCG to address those oral …

Factors Associated With The Utilization Of Community Dental Services Among Newly Incarcerated Adults, Whitney C. Graves, Starla Hairston Blanks, Lee S. Caplan, Katherine A. Erwin, Cynthia S. Ditslear, Henrie M. Treadwell

Journal of the Georgia Public Health Association

Background: Given the high rates of risky behaviors and health conditions among incarcerated individuals and the relationship between oral and general health, receipt of quality dental care is essential to the overall health and well-being of this population. However, few recent studies have focused on access to care and the state of oral health among incarcerated populations in the U.S. For the current study, a secondary data analysis was conducted to: 1) assess factors associated with the use of dental services among a newly incarcerated prison population in Georgia and 2) consider barriers related to utilization of dental services pre- …