Medicine and Health Sciences Commons^™

Complementary Feeding Practices And The Associated Risk Of Childhood Obesity Among Ethnic Minority Groups Living In High-Income Countries: Protocol For A Systematic Review And Meta-Analysis, Maido Tsenoli, Moien A.B. Khan, Linda Östlundh, Teresa Arora, Omar Omar

All Works

INTRODUCTION: Complementary feeding (CF) is defined as the period from when exclusive breast milk and formula are no longer sufficient for meeting the infant's nutritional needs. The CF period occurs from birth to 23 months of age. Though the recommended guidelines for introducing CF is from around 6 months of age, data indicates that some infants are introduced to food earlier than 6 months which can predispose children to obesity and overweight. Obesity in ethnic minority groups (EMG) is higher than their native counterparts and often tracks into adulthood. Hence, our aim was to conduct a systematic review and meta-analysis …

Examining Newcomer Women’S Experiences With Perinatal Care In Ontario, Canada: An Application Of Carspecken’S Critical Ethnographic Method, Jessica Pimienta, Oona St-Amant, Sepali Guruge, Corinne Hart, Cristina Catallo

The Qualitative Report

This article provides a practical description of Carspecken’s (1996) five-stage critical ethnographic approach entitled “Critical Qualitative Research (CQR).” Situated epistemologically and ontologically in the critical paradigm, this article is an exploration of critical ethnography as an important methodology for shedding light on the discursive culture of perinatal care for newcomer women during the three-month health insurance waiting period in Ontario, Canada. We argue that Carspecken’s approach to critical ethnography is especially instrumental in illuminating the social structures that contribute to health inequities.

Moving The Needle Toward Fair Compensation In Pediatric Nephrology., Darcy K. Weidemann, I A Ashoor, D E Soranno, R Sheth, C Carter, P D Brophy

Manuscripts, Articles, Book Chapters and Other Papers

Remuneration issues are a substantial threat to the long-term stability of the pediatric nephrology workforce. It is uncertain whether the pediatric nephrology workforce will meet the growing needs of children with kidney disease without a substantial overhaul of the current reimbursement policies. In contrast to adult nephrology, the majority of pediatric nephrologists practice in an academic setting affiliated with a university and/or children's hospital. The pediatric nephrology service line is crucial to maintaining the financial health and wellness of a comprehensive children's hospital. However, in the current fee-for-service system, the clinical care for children with kidney disease is neither sufficiently …

Cytokines In The Pathogenesis Of Large Granular Lymphocytic Leukemia, Colleen Isabelle, Amy Boles, Nitin Chakravarti, Pierluigi Porcu, Jonathan Brammer, Anjali Mishra

Department of Medical Oncology Faculty Papers

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disorder of older adults characterized by the clonal expansion of cytotoxic T/natural killer cells due to constitutive pro-survival signaling. In recent years, it has become clear that cytokines and their receptors are aberrantly expressed in LGLL cells. The exact initiation process of LGLL is unknown, although several cytokine-driven mechanisms have emerged. Elevated levels of several cytokines, including interleukin-15 (IL-15) and platelet-derived growth factor (PDGF), have been described in LGLL patients. Evidence from humans and animal models has shown that cytokines may also contribute to the co-occurrence of a wide range of autoimmune …

The Effect Of Interprofessional Conflict Resolution On Interprofessional Collaborative Practice Among Health Care Provider Teams In Hospitals, Sibylle Ugirase

Electronic Thesis and Dissertation Repository

Client needs and their complexities have increased, challenging multiple professionals to work together within health systems to reach better patient outcomes. Addressing this challenge requires interprofessional collaboration, which, while essential, may also breed conflict given that individuals from various health care disciplines each bring their unique perspectives into teamwork. While some degree of disagreement is expected, team members must be able to resolve conflicts to ensure effective patient care. However, limited information was available that described and clearly defined interprofessional conflict resolution as a concept.

The aim of this study was threefold. This study began with a concept analysis of …

Cross-Sectional Evaluation Of Chronic Medication Use Across Age Categories, Alecia N. Muwonge, Nedra Geddes-Mccarthy

NSU REACH and IPE Day

Purpose: The objective of this study was to estimate the use of chronic medications for hypertension, hyperlipidemia, hyperglycemia, and depression in adults over 18 years old. Background: Aging is associated with increased multimorbid conditions. Management of multimorbid conditions can be complex, making polypharmacy a prevalent problem in the adult population. Previous studies investigated the prevalence of chronic medication use in older adults, but none have evaluated the trends in use with increasing age. Methods: This retrospective cross-sectional study used general population data from NHANES during the 2011-2018 cohort years for a population of all adults 18 years of age and …

The Potential Role Of Virtual Reality Simulation To Meet Core Competencies In Non-Technical Skills In Physician Assistant Education, Jonathan D. Caplan

NSU REACH and IPE Day

please see poster presentation

डिमेंशिया से ग्रस्त व्यक्ति से संवाद करना, Ferzana Chaze, Nellie Groenenberg, Danielle Farrell, Rajni Sharma, Jasleen Kaur

Interacting with Persons with Dementia in South Asian Communities

No abstract provided.

2022-03-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2022-03-09 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-03-09_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Use Of Machine Learning Approaches And Statistical Techniques To Adjust For Nonadherence In Randomized Clinical Trials., Andrew G Chapple

School of Public Health Faculty Publications

No abstract provided.

Covid-19 Testing And Education At The Allen Family Center, Zoe Beck, Elijah Chong-Gum, Josselyn Gonzalez Perea, Sydnie Gould, Emily Planck, Kamila Tracey

Nursing Leadership in Community Engagement Projects

COVID-19 Testing and Education at the Allen Family Center

COVID-19 Testing and Education at the Allen Family Center The Mount Baker community is home to many families experiencing homelessness and housing instability. According to the Department of Community and Health Services, there is an estimate of 40,800 people in King County who experienced homelessness in 2020 (King County Department of Community, 2021). The Allen Family Center (AFC) is an inviting community resource, partnered with Mary’s Place and Mercy Housing Northwest, that serves families by providing assistance with housing, medical care, and childcare; recently, the AFC began providing COVID-19 testing available …

Viral Hepatitis - The Road Traveled And The Journey Remaining, Ghulam Fareed Malik, Noval Zakaria, Muhammad Ibrahim Majeed, Faisal Wasim Ismail

Section of Gastroenterology

Hepatitis is defined as inflammation of the liver and is commonly due to infection with The hepatotropic viruses - hepatitis A, B, C, D and E. Hepatitis carries one of the highest disease burdens globally and has caused significant morbidity and mortality among different patient populations. Clinical presentation varies from asymptomatic or acute flu-like illness to acute liver failure or chronic liver disease, characterized by jaundice, hepatomegaly and ascites among many other signs. Eventually, this can lead to fibrosis (cirrhosis) of the liver parenchyma and carries a risk of development into hepatocellular carcinoma. Hepatitis B and C are most notorious …

Key Factors For Improving Rigor And Reproducibility: Guidelines, Peer Reviews, And Journal Technical Reviews, Hong S. Lu, Alan Daugherty

Saha Cardiovascular Research Center Faculty Publications

To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing detailed prospective experimental designs and providing raw data are essential premises of rigor and reproducibility. Standard peer reviews and journal-specific technical and statistical reviews are critical factors for enhancing rigor and reproducibility. This brief review also shares some experience from Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal, that has implemented several mechanisms to enhance rigor and reproducibility for preclinical research.

Prevalence Of Dementia And Mild Cognitive Impairment In Indigenous Bolivian Forager-Horticulturalists, Margaret Gatz, Wendy J. Mack, Helena C. Chui, E. Meng Law, Giuseppe Barisano, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian, Jesus Bani Cuata, Amy R. Borenstein, Ellen E. Waters, Andrei Irimia, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, Michael I. Miyamoto, David E. Michalik, Daniel K. Cummings, Edmond Seabright, Angela R. Garcia, Paul L. Hooper, Thomas S. Kraft, Caleb E. Finch, Gregory S. Thomas, Jonathan Stieglitz, Benjamin C. Trumble, Michael D. Gurven, Hillard Kaplan

ESI Publications

Introduction

We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.

Methods

Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.

Results

Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. …

T-Cell Responses To Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses To The Colorectal Cancer Antigen, Guanylyl Cyclase C, John C. Flickinger, Jagmohan Singh, Yanki Yarman, Robert D Carlson, Joshua Barton, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. To date, over 30 clinical trials have been initiated testing Lm cancer vaccines across a wide variety of cancers, including lung, cervical, colorectal, and pancreatic. Here, we assessed the immunogenicity of an Lm vaccine against the colorectal tumor antigen GUCY2C (Lm-GUCY2C). Surprisingly, Lm-GUCY2C vaccination did not prime naïve GUCY2C-specific CD8+ T-cell responses towards the dominant H-2Kd-restricted epitope, GUCY2C254-262. However, Lm-GUCY2C produced robust CD8+ T-cell responses towards Lm-derived peptides suggesting that GUCY2C254-262 peptide may be subdominant to Lm-derived peptides. Indeed, incorporating immunogenic Lm peptides into an adenovirus-based GUCY2C …

Astrocyte-Secreted Chordin-Like 1 Regulates Spine Density After Ischemic Injury, Elena Blanco-Suarez, Nicola J Allen

Department of Neuroscience Faculty Papers

Ischemic injury occurs when the brain is deprived of blood flow, preventing cells from receiving essential nutrients. The injury core is the brain region directly deprived and is surrounded by the peri-infarct area, the region with recovery potential. In the peri-infarct area neurons undergo acute loss of dendritic spines, which modifies synaptic plasticity and determines neuronal survival. Astrocytes can be protective or detrimental to the ischemic injury response depending on the specific stage, yet we lack clear understanding of the underlying mechanisms. Chordin-like 1 (Chrdl1) is an astrocyte-secreted protein that promotes synaptic maturation and limits experience-dependent plasticity in the mouse …

Implementation Of Mindfulness-Based Movement For Sheltered Women, Rhea Rughani, Oliver Armand, Ashley Murrieta Ortega, Erin Murphy, Jordan Greenshield, Alorea Mae Domingo

Nursing Leadership in Community Engagement Projects

Introduction

In 1894, Angeline’s Day Center for Women was established through the Young Women’s Christian Association (YWCA) to serve the evolving needs of homeless women in Seattle by addressing existing racial and socioeconomic health disparities (Schafranek, 2021). Angeline’s provides overnight and day services to address the COVID-19 related heightened community need, including healthcare, meals, and hygiene services to 40 women (Schafranek, 2021). In 2022, the Seattle Pacific University (SPU) Lydia Green Nursing Program partnered with Angeline's to analyze and address the needs of the population they serve. The undergraduate nursing students performed a windshield survey and developed a community diagnosis …

Zoom In To Fitness: A Novel Way Of Bringing Fitness Experts To Seniors, Tessa Wells, Jenna Boyd, Gabriel Fisher, Victoria Kranz, Mckenzi Petricko

Posters and Presentations: Physical Therapy

Participants will discover a how a local educational institution was able to think creatively and bring much-needed programming to local seniors during the height of the COVID-19 pandemic restrictions. Participants will also experience first-hand how a virtual physical activity session can be delivered safely and effectively in the comfort of the senior’s own living environment or a group fitness room environment. Participants will be asked to think creatively of possible community partners, as well as possible barriers and facilitators to implementing this innovative wellness strategy. Information will be presented regarding additional activities that could be presented in this format such …

Brief Report: Cause Of Death Among People Discharged From Infective Endocarditis Related Hospitalization—West Virginia, 2016–2019, Zheng Dai, Gordon S. Smith, Brian Hendricks, Ruchi Bhandari

Faculty & Staff Scholarship

Background and Objectives

Compare proportion of all-cause and cause-specific mortality among West Virginia Medicaid enrollees who were discharged from infective endocarditis (IE) hospitalization with and without opioid use disorder (OUD) diagnosis.

Methods

The proportions of cause-specific deaths among those who were discharged from IE-related hospitalizations were compared by OUD diagnosis.

Results

The top three underlying causes of death discharged from IE hospitalization were accidental drug poisoning, mental and behavioral disorders due to polysubstance use, and cardiovascular diseases. Of the total deaths occurring among patients discharged after IE-related hospitalization, the proportion has increased seven times from 2016 to 2019 among the …

The Seventh International Rasopathies Symposium: Pathways To A Cure—Expanding Knowledge, Enhancing Research, And Therapeutic Discovery, Maria I. Kontaridis, Amy E. Roberts, Lisa Schill, Lisa Schoyer, Beth Stronach, Gregor Andelfinger, Yoko Aoki, Marni E. Axelrad, Annette Bakker, Alejandro Lopez-Juarez

Health & Biomedical Sciences Faculty Publications and Presentations

RASopathies are a group of genetic disorders that are caused by genes that affect the canonical Ras/mitogen-activated protein kinase (MAPK) signaling pathway. Despite tremendous progress in understanding the molecular consequences of these genetic anomalies, little movement has been made in translating these findings to the clinic. This year, the seventh International RASopathies Symposium focused on expanding the research knowledge that we have gained over the years to enhance new discoveries in the field, ones that we hope can lead to effective therapeutic treatments. Indeed, for the first time, research efforts are finally being translated to the clinic, with compassionate use …

Chronic Relapsing Neutrophilic Meningitis As The Sole Manifestation Of Nocardiosis In A Patient With Mixed Connective Tissue Disease., M Anthony Albornoz, Erin K Threlfall, Michael Baldassari, Lawrence J Livornese

Department of Neurosurgery Faculty Papers

We describe a rare case of a patient with mixed connective tissue disease maintained on chronic oral corticosteroids, who was hospitalized on five occasions over five consecutive months due to persistent relapsing neutrophilic meningitis caused by Nocardia asteroides. Immunosuppression due to the chronic use of corticosteroids was identified as the underlying mechanism of susceptibility. Our report highlights the challenges associated with systemic Nocardiosis, particularly in the immunocompromised host.

Functional Nasal Breathing Rehabilitation: Effectiveness And Feasibility Of An Online Integrative Breathing Therapy Protocol, Rosalba Courtney, Roger Engel, Sandra Grace, Anna Potts, Brooke Riordan, Kaitlyn Ireland, Courtney Osbourne, Avinash Sukhtankar

International Journal of Orofacial Myology and Myofunctional Therapy

Purpose: Nasal disuse and mouth breathing are associated with negative structural, functional, postural, occlusal, and behavioural changes. While there is some research to suggest that nasal breathing exercises can reduce mouth breathing, clinical protocols have not been extensively investigated. The purpose of this research was to determine the feasibility and effectiveness of a nasal breathing rehabilitation protocol based on Integrative Breathing Therapy principles called Functional Nasal Breathing Rehabilitation (FNBR).

Methods: Twenty-three participants with symptoms of nasal obstruction and self-reported mouth breathing completed the 4-week online FNBR training. Outcome measures included the Nasal Obstruction Symptom Evaluation (NOSE) scale, a numeric rating …

Understanding Queer Women’S Satisfaction With Healthcare Providers: The Role Of Positive Lgb Identity And Communication, Maddie Luebe

Honors Theses

Much research has explored the negative effects of having a queer identity in healthcare, such as stigmatization and discrimination, but little research examined the potential benefits of a positive LGBTQ identity in healthcare. This study investigated the relationship between having a positive LGBTQ identity and provider satisfaction through comfort communicating with a provider. This study also considered the potential effect of participants’ fear of provider heterosexism in this relationship. Survey data were collected from 506 queer-identified women in the United States. Using moderated mediation, results found that more positive feelings associated with one’s queer identity was associated with increased comfort …

Elucidating Mechanisms Of Genetic Cross-Disease Associations At The Procr Vascular Disease Locus, David Stacey, Lingyan Chen, Paulina J Stanczyk, Joanna M M Howson, Amy M Mason, Stephen Burgess, Stephen Macdonald, Jonathan Langdown, Harriett Mckinney, Kate Downes, Neda Farahi, James E Peters, Saonli Basu, James S Pankow, Weihong Tang, Nathan Pankratz, Maria Sabater-Lleal, Paul S De Vries, Nicholas L Smith, Amy D Gelinas, Daniel J Schneider, Nebojsa Janjic, Nilesh J Samani, Shu Ye, Charlotte Summers, Edwin R Chilvers, John Danesh, Dirk S Paul

Student and Faculty Publications

Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human recall-by-genotype and in vitro experimentation, we demonstrate that PROCR-219Gly increases plasma levels of (activated) protein C through endothelial protein C receptor (EPCR) ectodomain shedding in endothelial cells, …

Self-Medication Practices In Medical Students During The Covid-19 Pandemic: A Cross-Sectional Analysis, Farah Yasmin, Muhammad Sohaib Asghar, Unaiza Naeem, Hala Najeeb, Hamza Nauman, Muhammad Nadeem Ahsan, Abdullah Khan Khattak

Medical College Documents

Background and objectives: During the pandemic, the growing influence of social media, accessibility of over-the-counter medications, and fear of contracting the virus may have led to self-medication practices among the general public. Medical students are prone to such practices due to relevant background knowledge, and access to drugs. This study was carried out to determine and analyze the prevalence of self-medication practices among medical students in Pakistan.
Materials and methods: This descriptive, cross-sectional study was conducted online in which the participants were asked about the general demographics, their self-medication practices and the reasons to use. All participants were currently enrolled …

Optimal Iron Content In Ready-To-Use Therapeutic Foods For The Treatment Of Severe Acute Malnutrition In The Community Settings: A Protocol For The Systematic Review And Meta-Analysis, Aamer Imdad, Melissa François, Fanny F. Chen, Abigail Smith, Olivia Tsistinas, Emily Tanner Smith, Jai K. Das, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Introduction: The current standard of care for children with severe acute malnutrition (SAM) involves using ready-to-use therapeutic food (RUTF) to promote growth; however, the precise formulation to achieve optimal recovery remains unclear. Emerging research suggests that alternative RUTF formulations may be more effective in correcting SAM-related complications such as anaemia and iron deficiency. This systematic review commissioned by the WHO aims to synthesise the most recent research on the iron content in RUTF and related products in the community-based treatment of uncomplicated severe malnutrition in children aged 6 months and older.
Methods and analysis: We will search multiple electronic databases. …

Agrobacterium Species Bacteraemia, Switzerland, 2008 To 2019: A Molecular Epidemiological Study, Lisa Balmer, Helena M B Seth-Smith, Adrian Egli, Carlo Casanova, Andreas Kronenberg, Jacques Schrenzel, Jonas Marschall, Rami Sommerstein

2020-Current year OA Pubs

BACKGROUND: Agrobacterium spp. are infrequent agents of bloodstream infections linked to healthcare-associated outbreaks. However, it is unclear if outbreaks also occur across larger geographic areas. Triggered by two local clusters from putative point sources, our aim was to detect potential additional clusters in Switzerland.

METHODS: We performed a nationwide descriptive study of cases in Switzerland based on a prospective surveillance system (Swiss Centre for Antibiotic Resistance, anresis.ch), from 2008 to 2019. We identified patients with Agrobacterium spp. isolated from blood cultures and used a survey to collect clinical-epidemiological information and susceptibility testing results. We performed whole genome sequencing (WGS) of …

Dpo: Diffuse Pulmonary Ossification - A Diagnostic Challenge, Gaetano Rea, Giuliana Giacobbe, Danila Caroppo, Silvia Iovine, Roberta Lieto, Marialuisa Bocchino, Tullio Valente, Angelantonio Maglio, Alessandro Vatrella

Translational Medicine @ UniSa

Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic …