Medicine and Health Sciences Commons^™

Application Of The Paediatric Medical Traumatic Stress Model To The Mental Health Experience Of Young People Living With Type 1 Diabetes: A Qualitative Study, Rigel Paciente, Sara Coombs, Karen Lombardi, Helen Milroy, Keely Bebbington, Heather Roby, Craig E. Taplin, Nicole Wickens, Stella Rose, Alix Woolard

Research outputs 2022 to 2026

Despite the various traumatic events that a young person living with type 1 diabetes (T1D) may experience, little is known about the burden and manifestation of traumatic stress in this population. Though mental health outcomes have been explored generally, medical trauma-sensitive approaches to understanding these experiences remain limited. We utilised a qualitative descriptive approach to explore the impact of T1D on young people’s mental health through the paediatric medical traumatic stress model (PMTS). Young people aged 13–30 living with T1D were interviewed. These interviews were recorded, transcribed, and analysed using Reflexive Thematic Analysis. Three main themes were generated: (1) perceived …

Discriminative Performance Of Externally Validated Dementia Risk Prediction Models: A Systematic Review And Meta-Analysis, Blossom C.M. Stephan, Jacob Brain, Kaarin J. Anstey, Tanya Buchanan, Claire V. Burley, Elissa Burton, Jennifer Dunne, Linda Errington, Matthew Gorringe, Zhongyang Guan, Bronwyn Myers, Serena Sabatini, Marc Sim, William Stephan, Eugene Yee Hing Tang, Narelle Warren, Mario Siervo

Research outputs 2022 to 2026

Background: Data on the external validation of current dementia risk prediction models has not yet been systematically synthesised. This systematic review and meta-analysis collated results from three previous reviews to evaluate the predictive discriminative performance of dementia risk models when validated in population-based settings. Methods: Embase (via Ovid), Medline (via Ovid), Scopus, and Web of Science were searched from inception to June 2022 with an updated search conducted up to November 2024. Included studies (1) had a population-based cohort design; (2) assessed incident late-life (i.e. ≥ 60 years) dementia; and (3) reported predictive performance of at least one dementia risk …

Enhancing Independence And Social Connection: The Impact Of A Tailored Exercise Program On New Residents Transitioning Into Australian Residential Care Facilities, Stacey Scott, Annette Raynor, Julie Dare, Jennifer Grieve, Leesa Costello

Research outputs 2022 to 2026

Background: Transitioning from independent living to a residential care facility often results in a significant loss of independence, autonomy, and connectedness, leaving new residents with profound feelings of loss and grief. In light of these challenges, this study explored the potential benefits of a tailored in-house exercise program for new residents. Methods: The study took place in an Australian residential care facility and included four new residents (aged 72 to 88, 75% female), who participated in a 12-week tailored exercise program led by an exercise physiologist. A focused ethnographic approach was used to obtain a comprehensive data set, drawing on …

The Impact Of Testing-Parameter Variability On Force Production In The Isometric Single-Leg Long-Lever Bridge: Implications For Training And Testing Rigor In Sporting Environments, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort

Research outputs 2022 to 2026

Background: The aim of this study was to determine the impact of knee angle variability on force production outcomes during the single-leg isometric long-lever bridge, thus providing monitoring guidelines for testing rigor with direct implications for feasibility across a variety of high-performance sporting environments. Methods: Thirty men (age: 19.4 ± 1.3 years; height: 179.8 ± 6.3 cm; body mass: 80.4 ± 10.3 kg) and 14 women (age: 20.0 ± 1.3 years; height: 166.9 ± 7.2 cm; body mass: 64.4 ± 7.4 kg) all of whom were Division 3 athletes with no recent injury history volunteered to participate in the study. …

A Genomic Approach For Accurate Identification Of Closely Related Species With Next-Generation Sequencing Samples, Nour Al Dain Marzouka, Amira Al-Aamri, Fatima Alshamsi, Mariam Khalili, Sarah El Hajj Chehadeh, Meera S. Mohamed, Yassir Mohammed Eltahir, Rafeek Koliyan, Mohamed Moustafa Abdelhalim, Assem Attia, Mira Mousa, Guan Tay, Habiba Alsafar

Research outputs 2022 to 2026

Accurate species identification from Whole Genome Sequencing (WGS) data remains challenging, particularly for closely related species such as sheep (Ovis aries) and goats (Capra hircus). Through analysis of mapping quality metrics and Kraken2 taxonomic classification of 40 WGS sheep and goat samples, we demonstrate that conventional approaches yield ambiguous results, with overlapping alignment rates and inconclusive taxonomic assignments. We present a robust comparative genomic approach that uses species-specific genomic regions to distinguish these species in WGS samples. We define species-specific regions as those exhibiting distinctive coverage patterns: average coverage when samples are aligned to their matching reference genome but absent/low …

Primary Breast Sarcoma In Pediatric, Adolescent, And Young Adult Patients: A Single-Institution Retrospective Review, Amelie D. Perrier

Summer Research Program Abstracts

No abstract provided.

Mtorc2-Nav1.2 Signaling Drives Early Hyperexcitability In Alzheimer’S Disease Mouse Model, Nolan M Dvorak, Jeffrey L Noebels

Faculty, Staff and Students Publications

Hyperexcitability is a biomarker of early-stage Alzheimer’s Disease (AD) and hastens cognitive decline later in its course. Mechanistic target of rapamycin (mTOR) signaling contributes to the slope of this trajectory, as evidenced by early increased brain expression and the rescue of hyperexcitability by genetic deletion of mTOR complex 2 (mTORC2); however, a molecular mechanism directly linking mTOR signaling to membrane hyperexcitability in early-stage AD remains elusive. Here, we show that hyperactive mTOR signaling stimulates the voltage-gated Na+ channel 1.2 (Nav1.2), a previously identified downstream phosphorylation target of mTORC2 and a key regulator of membrane electrogenesis. Augmented Nav1.2 channel function induced …

Sociodemographic And Clinical Factors In Nmosd And Mogad: Disability, Psychiatric Burden, And Disparities, Neha S. Patil

Summer Research Program Abstracts

No abstract provided.

Evaluating The Role Of Perineural Invasion In The Risk Of Local Recurrence Of Cutaneous Melanoma After Adjuvant Radiation Therapy, Riya T. Patel

Summer Research Program Abstracts

No abstract provided.

Biomechanical Gait Analysis To Classify Neurological Gait Scores In A Spina Bifida Sheep Model, Shreya Pandiri

Summer Research Program Abstracts

No abstract provided.

Improving Adhd Screenings Through Quality Improvement, Workflow Optimization, And Evaluation Of A 6-Item Short Form Screening Tool, Paris A. Nix

Summer Research Program Abstracts

No abstract provided.

Environmental Or Occupational Heavy Metal Exposure In The Development And Progression Of End Stage Kidney Disease: A Systematic And Network Meta-Analysis, Lauren Nguyen

Summer Research Program Abstracts

No abstract provided.

Evaluating Pediatric Surgical Care Delivery Across Settings: National Trends In Ambulatory, Outpatient, And Inpatient Models, Kyle C. Nevitt

Summer Research Program Abstracts

No abstract provided.

The Benefits And Barriers To Expanding Crna Programs In Michigan, Grace Van Zweden

Honors Theses

The demand for Certified Registered Nurse Anesthetists (CRNAs) and their delivery of safe, high-quality anesthesia care has increased significantly due to nationwide anesthesia provider shortages and the growing reliance on CRNAs to meet healthcare system needs. This demand underscores the importance of expanding nurse anesthesia programs in Michigan and across the United States to support nurses pursuing advanced education and to improve patient access to essential care within their communities. The CRNA profession has evolved over time to meet the changing needs of the healthcare system, and current CRNA programs require applicants to satisfy rigorous and highly specific admission criteria. …

Thinking Out Loud: Distinguishing Overt, Mimed, And Covert Speech Using Stereo-Electroencephalography For Brain-Computer Interfaces, Hasan K. Mubarak

Summer Research Program Abstracts

No abstract provided.

Parental Perceptions Of Child Health And Their Alignment With Clinical Indicators In Overweight Or Obese Low-Income Children, Katherine Moorman-Wolfe

Summer Research Program Abstracts

No abstract provided.

The Association Between Early Postnatal Phosphorus, Magnesium, And Calcium Levels And Neurodevelopmental Outcomes In Extremely Preterm Infants: A Retrospective Cohort Study, Alyssa N. Miller

Summer Research Program Abstracts

No abstract provided.

Complex Care: Impact Of Congenital Malformations And Caregiver Health Literacy On Perceived Outcomes, Poorna R. Menon

Summer Research Program Abstracts

No abstract provided.

Saving Face: Use Of Restraints In Mvcs Mitigates Surgery, Tbi, And C-Spine Injuries In Pediatric Facial Fracture Trauma, Dustin Rose Mchalffey

Summer Research Program Abstracts

No abstract provided.

Individualized Kinematically-Driven Contact Modeling Offers A Reliable Alternative For Periacetabular Osteotomy Planning, James J. Mcginley

Summer Research Program Abstracts

No abstract provided.

Translating Fap-Targeted Probes To The Or: Preclinical Evaluation Of Fapi-Cy5 In Pancreatic Cancer, Nicolette R. Mardik

Summer Research Program Abstracts

No abstract provided.

Evaluating Large Language Models For Cpt Code Prediction In Pediatric Orthopedic Surgery, Krishi S. Manem

Summer Research Program Abstracts

No abstract provided.

A Head Of The Curve: Investigating Helmet Therapy Compliance In Patients With Craniosynostosis, Racquel V. Lyn

Summer Research Program Abstracts

No abstract provided.

Application Of Artificial Intelligence (Ai) In Cancer Symptom Management For Adult Cancer Survivors: A Scoping Review, Tao Wang, Haiying Wang, Mengyuan Li, Daniel Bressington, Daniel Terry, Guanjin Wang, Wai Hang Kwok, Jing Yu (Benjamin) Tan

Research outputs 2022 to 2026

Background and aim: Artificial Intelligence (AI) has been increasingly used in cancer survivorship to support symptom management. This scoping review aimed to map existing evidence on AI applications in cancer symptom management for adult cancer survivors, including AI model development, AI-enabled intervention delivery and adoption, symptom targets, key features of the AI approaches used, reported outcomes, influencing factors, and research gaps to inform future priorities.

Method: This scoping review was conducted in accordance with the Joanna Briggs Institute methodology for scoping reviews. Eight electronic databases were comprehensively searched in November 2025 and updated in March 2026. Empirical studies published in …

Consensus Recommendations For Movement Therapies Of Patients With Heritable Vascular Diseases: A Modified Delphi Study, Randy Liu

Summer Research Program Abstracts

No abstract provided.

Too Many Hands On Deck: Assessing The Appropriateness Of Hand Surgery Transfers To The Texas Medical Center, Khang T. Le

Summer Research Program Abstracts

No abstract provided.

Enucleation Versus Anatomical Resection Of Malignant Pancreatic Tumors In Children And Young Adults, Alexander Lee

Summer Research Program Abstracts

No abstract provided.

Real-World Outcomes Of Patients With Geographic Atrophy Developing Neovascular Age-Related Macular Degeneration After Receiving Anti-Complement Therapy, Charles F. Lano Iii

Summer Research Program Abstracts

No abstract provided.

Development Of A Culture System For Eosinophils Derived From Human Cord Blood Stem Cells, Christian Lachance

Summer Research Program Abstracts

No abstract provided.

Acceleration Of Coagulation Kinetics For Clot Burst Pressure Assessment, Hanuk Kwon

Summer Research Program Abstracts

No abstract provided.