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Full-Text Articles in Medicine and Health Sciences

The Role Of Herbal Medicines In Central American Indigenous Communities; Improving Accessibility To Type 2 Diabetes Mellitus Treatment, Sarai Ortega Jan 2023

The Role Of Herbal Medicines In Central American Indigenous Communities; Improving Accessibility To Type 2 Diabetes Mellitus Treatment, Sarai Ortega

CMC Senior Theses

Indigenous communities in Central America have used various plant medications to treat illnesses and diseases for centuries. Clinicians must consider improving traditional healthcare methods that are intrinsic to indigenous communities in order to increase access to effective treatments, particularly for diseases that these communities are more at risk for. This work aims to propose a method to identify whether traditional preparations of five plants (Anacardium occidentale L., Hamelia patens Jacq., Momordica charantia L, Neurolaena lobota L. R. Br. Ex Cass., and Tecoma stans L. juss. ex Kunth) can reduce blood glucose levels in rats with type two diabetes. Additionally, …


Establishment Of An In Vivo Streptozotocin-Induced Type 1 Diabetes Model Recapitulating Early Brain And Retinal Fibrosis, Kia Bourdot, Lucy Dawson, Igor Kuzin, Arturo Bravo Nuevo, Zeus Antonello Dec 2022

Establishment Of An In Vivo Streptozotocin-Induced Type 1 Diabetes Model Recapitulating Early Brain And Retinal Fibrosis, Kia Bourdot, Lucy Dawson, Igor Kuzin, Arturo Bravo Nuevo, Zeus Antonello

Cooper Rowan Medical Journal

INTRODUCTION: Diabetes has risen to one of the top American public health concerns. The hyperglycemic state of chronic diabetes leads to microvascular and macrovascular changes that predispose patients to delayed wound healing and organ fibrosis. The validation of models to specifically detect early, quantifiable fibrotic changes seen in the diabetic state is of fundamental importance for understanding the diabetic pathophysiology and exploring earlier management options. Here, we investigated if we could detect early signs of internal fibrosis in a streptozotocin (STZ) diabetic mouse model by quantifying α-SMA expression in various organs using flow cytometry.

METHODS: We used a low-dose STZ-induced …


Diabetes Prevention And Management Education For Punjabi-Sikh Older Adults, Mandeep K. Gill Dec 2022

Diabetes Prevention And Management Education For Punjabi-Sikh Older Adults, Mandeep K. Gill

Doctor of Nursing Practice (DNP) Projects

Abstract

Background: South Asians from Bangladesh, Pakistan, and India have a higher prevalence of diabetes than the general global population and are also more susceptible to developing diabetes due to biological and lifestyle factors. The South Asian diet is high in refined grains and monounsaturated fatty acids, increasing the risk of diabetes.

Local Problem: Congregants of a Sikh gurdwara (place of worship) lacked knowledge of diet and lifestyle in relation to preventing and managing diabetes. Many senior congregants have been diagnosed with diabetes or are at high risk of developing the disease.

Methods: Knowledge of diabetes prevention and management were …


The Importance Of Stigma Theory For Clinical Decisions Related To Diabetic Foot Amputations, Rachael Garcia, Callie Bartkowiak, Alison Nesbitt Do Dec 2022

The Importance Of Stigma Theory For Clinical Decisions Related To Diabetic Foot Amputations, Rachael Garcia, Callie Bartkowiak, Alison Nesbitt Do

Clinical Research in Practice: The Journal of Team Hippocrates

The authors examine the unconsidered impact of social stigma theory on the shared clinical decision-making process for a patient with foot osteomyelitis and MRSA bacteremia facing the prospect of an amputation.


Process Evaluation Of A Community Asset Mapping Protocol For Diabetes Prevention And Management, Andrea Peterson Dec 2022

Process Evaluation Of A Community Asset Mapping Protocol For Diabetes Prevention And Management, Andrea Peterson

Capstone Experience

Prediabetes and type 2 diabetes mellitus (DM) are highly prevalent conditions with new diagnoses occurring each year (Centers for Disease Control and Prevention, 2022a). Type 2 DM negatively impacts many aspects of life, to include social, financial, cultural, and everyday living. Asset mapping is a useful tool to build upon existing resources to help community members identify and expand services based on understanding the interconnected systems that influence type 2 DM prevention, screening, education, and care management. An Asset Mapping Protocol was created and piloted through a rural community coalition in Nebraska. The protocol includes an activity for community stakeholders …


Characterizing The Diversity Of Mhc Conserved Extended Haplotypes Using Families From The United Arab Emirates, Halima Alnaqbi, Guan K. Tay, Sarah El Hajj Chehadeh, Habiba Alsafar Dec 2022

Characterizing The Diversity Of Mhc Conserved Extended Haplotypes Using Families From The United Arab Emirates, Halima Alnaqbi, Guan K. Tay, Sarah El Hajj Chehadeh, Habiba Alsafar

Research outputs 2022 to 2026

Aside from its anthropological relevance, the characterization of the allele frequencies of genes in the human Major Histocompatibility Complex (MHC) and the combination of these alleles that make up MHC conserved extended haplotypes (CEHs) is necessary for histocompatibility matching in transplantation as well as mapping disease association loci. The structure and content of the MHC region in Middle Eastern populations remain poorly characterized, posing challenges when establishing disease association studies in ethnic groups that inhabit the region and reducing the capacity to translate genetic research into clinical practice. This study was conceived to address a gap of knowledge, aiming to …


Use Of Text Messaging For Type Two Diabetes Management In Patients Over Sixty-Five, Charles Head Nov 2022

Use Of Text Messaging For Type Two Diabetes Management In Patients Over Sixty-Five, Charles Head

Master of Science in Nursing Family Nurse Practitioner

Why is there a need for tight glucose control for diabetics sixty-five years old or older? Tight control of glucose which can be trended as a 90-day snapshot of blood sugar control is measured using HgA1C levels(Centers for Disease Control and Prevention, 2019). HgA1c levels under six percent in diabetics have been shown to reduce diabetic complications that be detrimental to health(Krapek et al., 2004). Adults aged sixty-five years old or older are also at greater risk for the development of acute and chronic diseases that are a result of poor blood sugar management(Leung et al., 2018). Adherence to prescribed …


Diabetes-Related Bias In Electronic Health Records And International Classification Of Diseases., Mihail Zilbermint Nov 2022

Diabetes-Related Bias In Electronic Health Records And International Classification Of Diseases., Mihail Zilbermint

Journal of Community Hospital Internal Medicine Perspectives

Diabetes mellitus is a chronic health condition that affects the body's ability to convert food into energy. People living with diabetes, as well as doctors and hospitals, struggle to handle the challenge. Among these challenges is that the field of diabetology is filled with bias. People living with diabetes will say that “diabetes does not define them,” yet they often refer to themselves as “diabetics.” Doctors are frequently “trained” to call people “diabetics,” and I am one of them. Psychological consequences associated with diabetes and obesity bias and stigma have been previously reported studied. People with diabetes may experience stigma …


Metabolic Syndrome In Fasting And Non-Fasting Participants: The Uae Healthy Future Study, Fatima Mezhal, Amar Ahmad, Abdishakur Abdulle, Andrea Leinberger-Jabari, Abderrahim Oulhaj, Abdulla Aljunaibi, Abdulla Alnaeemi, Ayesha S. Al Dhaheri, Eiman Alzaabi, Fatma Al-Maskari, Fatme Alanouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Manal Alblooshi, Mohammad Al-Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar El-Shahawy, Rami H. Al-Rifai, Scott Sherman, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Luai A. Ahmed Nov 2022

Metabolic Syndrome In Fasting And Non-Fasting Participants: The Uae Healthy Future Study, Fatima Mezhal, Amar Ahmad, Abdishakur Abdulle, Andrea Leinberger-Jabari, Abderrahim Oulhaj, Abdulla Aljunaibi, Abdulla Alnaeemi, Ayesha S. Al Dhaheri, Eiman Alzaabi, Fatma Al-Maskari, Fatme Alanouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Manal Alblooshi, Mohammad Al-Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar El-Shahawy, Rami H. Al-Rifai, Scott Sherman, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Luai A. Ahmed

All Works

Introduction: Metabolic syndrome (MetS) is a multiplex of risk factors that predispose people to the development of diabetes and cardiovascular disease (CVD), two of the major non-communicable diseases that contribute to mortality in the United Arab Emirates (UAE). MetS guidelines require the testing of fasting samples, but there are evidence-based suggestions that non-fasting samples are also reliable for CVD-related screening measures. In this study, we aimed to estimate MetS and its components in a sample of young Emiratis using HbA1c as another glycemic marker. We also aimed to estimate the associations of some known CVD risk factors with MetS in …


Resistant Starch As A Dietary Intervention To Limit The Progression Of Diabetic Kidney Disease, Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson Nov 2022

Resistant Starch As A Dietary Intervention To Limit The Progression Of Diabetic Kidney Disease, Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson

Research outputs 2022 to 2026

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a number of pathways, including inflammation, oxidative stress, and the gut-kidney axis, which may be amenable to dietary therapy. Resistant starch (RS) is a dietary fibre that alters the gut microbial consortium, leading to an increase in the microbial production of short chain fatty acids. Evidence from animal and human studies indicate that short chain fatty acids are able to attenuate inflammatory …


Effects Of Glp-1 Receptor Agonists On Cardiovascular Outcomes In Patients With Type 2 Diabetes And Chronic Kidney Disease: A Systematic Review And Meta-Analysis, Michael S. Kelly, Jelena Lewis, Hindu Rao, Jessica Carter, Ivan Portillo, Richard Beuttler Oct 2022

Effects Of Glp-1 Receptor Agonists On Cardiovascular Outcomes In Patients With Type 2 Diabetes And Chronic Kidney Disease: A Systematic Review And Meta-Analysis, Michael S. Kelly, Jelena Lewis, Hindu Rao, Jessica Carter, Ivan Portillo, Richard Beuttler

Pharmacy Faculty Articles and Research

Aim

To evaluate the cardiovascular outcomes of glucagon-like peptide-1 receptor agonists (GLP1-RA) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD).

Materials and Methods

We searched PubMed, Ovid MEDLINE, CINAHL, and Web of Science databases for randomized controlled trials reporting event rates for a composite cardiovascular outcome of cardiovascular death, myocardial infarction, and stroke in patients with T2DM and CKD receiving GLP1-RA or placebo. Studies were restricted to those reporting specific event rates for patients with CKD separately from the overall population. We conducted a meta-analysis using a random-effects model. This meta-analysis was registered on PROSPERO (CRD42022320157). …


The Reported External Traumas Among People With Diabetes-Related Foot Ulcers And Their Outcomes: A Systematic Review Of Case Reports, Ma'en Zaid Abu-Qamar, Vivien Kemp, Lisa Whitehead Oct 2022

The Reported External Traumas Among People With Diabetes-Related Foot Ulcers And Their Outcomes: A Systematic Review Of Case Reports, Ma'en Zaid Abu-Qamar, Vivien Kemp, Lisa Whitehead

Research outputs 2022 to 2026

The objective of this systematic review was to collate evidence published in case reports on the reported origins of external traumas that contribute to the development of diabetic foot ulcers and their outcomes. The review also aimed to suggest reporting criteria for external traumas contributing to the development of diabetic foot ulcers. The search strategy led to the identification of 1224 articles across six electronic databases. Additional articles were also sourced from other electronic platforms (Google scholar) and the reference lists of the included case reports. Ninety-four articles met the inclusion criteria and were published between 1989 and 2020. The …


Chronic Illness Education 2022: Diabetes Mellitus Education For Adults In Southeast Michigan, Muhammad Ahmed, Ahmad Kofahi, Caleb Richard, Hadi El Ammar, Huda Warsame, Janice Gibbons, Jodene Takahashi Sep 2022

Chronic Illness Education 2022: Diabetes Mellitus Education For Adults In Southeast Michigan, Muhammad Ahmed, Ahmad Kofahi, Caleb Richard, Hadi El Ammar, Huda Warsame, Janice Gibbons, Jodene Takahashi

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: A Recipe For Healthy Living, Awad Maria, Andrew Gregory, Andrew Rabah, Kia Sweeney, Laura Aravena, Nicholas Livingston, Tabassum Chowdhury Sep 2022

Chronic Illness Education 2022: A Recipe For Healthy Living, Awad Maria, Andrew Gregory, Andrew Rabah, Kia Sweeney, Laura Aravena, Nicholas Livingston, Tabassum Chowdhury

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: Addressing Risk Of Body Image And Eating Disorders In Adolescents With Type I Diabetes, Ahmad El-Moussa, Dhruva Kadiyala, Kavitha Mohanarajan, Kevin Kim, Michael Brennan, Rajaa Shoukfeh, Ruth Amoakohene Sep 2022

Chronic Illness Education 2022: Addressing Risk Of Body Image And Eating Disorders In Adolescents With Type I Diabetes, Ahmad El-Moussa, Dhruva Kadiyala, Kavitha Mohanarajan, Kevin Kim, Michael Brennan, Rajaa Shoukfeh, Ruth Amoakohene

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: Helping Patients Access Low-Cost Diabetes Supplies And Medications, Iyanna Peppers, Laial Baltaji, Lucas Edgren, Lyndsay Archer, Molly Wilson Sep 2022

Chronic Illness Education 2022: Helping Patients Access Low-Cost Diabetes Supplies And Medications, Iyanna Peppers, Laial Baltaji, Lucas Edgren, Lyndsay Archer, Molly Wilson

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: Increasing Wound Care Vigilance In Adult Diabetic Patients With Neuropathy, Gowri Chandrashekar, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar Sep 2022

Chronic Illness Education 2022: Increasing Wound Care Vigilance In Adult Diabetic Patients With Neuropathy, Gowri Chandrashekar, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: Developing A Hands-On Tool For Increased Accountability Amongst Diabetic Children, Kassandra Solrud, Bijan Sagman, Elena Carrillo, Gokturk Tepe, Itzick Nahmoud, Siena Snyder, William Crouch Sep 2022

Chronic Illness Education 2022: Developing A Hands-On Tool For Increased Accountability Amongst Diabetic Children, Kassandra Solrud, Bijan Sagman, Elena Carrillo, Gokturk Tepe, Itzick Nahmoud, Siena Snyder, William Crouch

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: Diabetes Management In Adults In The Detroit Area, David Asebiode, Chase Morrison, Erin Bybee, Isaiah Hough, Madison Graifman, Mehrnoosh Ghafouri Abbasabadi, Saranya Madan Sep 2022

Chronic Illness Education 2022: Diabetes Management In Adults In The Detroit Area, David Asebiode, Chase Morrison, Erin Bybee, Isaiah Hough, Madison Graifman, Mehrnoosh Ghafouri Abbasabadi, Saranya Madan

Patient Education Projects

No abstract provided.


Chronic Illness Education 2022: Type Ii Diabetes Management In Adults: Medications And Community Resources, Varag Abed, Camila Arellano, Carolyn Baldwin, Ethan Ervin, Haya Beydoun, Mahnoor Ayub, Yoshio Wagner Sep 2022

Chronic Illness Education 2022: Type Ii Diabetes Management In Adults: Medications And Community Resources, Varag Abed, Camila Arellano, Carolyn Baldwin, Ethan Ervin, Haya Beydoun, Mahnoor Ayub, Yoshio Wagner

Patient Education Projects

No abstract provided.


Predicting Insulin Pump Therapy Settings, Riccardo L. Ferraro, David Grijalva, Alex Trahan Sep 2022

Predicting Insulin Pump Therapy Settings, Riccardo L. Ferraro, David Grijalva, Alex Trahan

SMU Data Science Review

Millions of people live with diabetes worldwide [7]. To mitigate some of the many symptoms associated with diabetes, an estimated 350,000 people in the United States rely on insulin pumps [17]. For many of these people, how effectively their insulin pump performs is the difference between sleeping through the night and a life threatening emergency treatment at a hospital. Three programmed insulin pump therapy settings governing effective insulin pump function are: Basal Rate (BR), Insulin Sensitivity Factor (ISF), and Carbohydrate Ratio (ICR). For many people using insulin pumps, these therapy settings are often not correct, given their physiological needs. While …


Webinars As A Tool For Increasing Awareness Of Diabetes Prevention And Management Programs, Cindy Jenkins, Carrie Durward, April Litchford, Catherine Hansen, Annette Prall, Caitlyn Jasumback Sep 2022

Webinars As A Tool For Increasing Awareness Of Diabetes Prevention And Management Programs, Cindy Jenkins, Carrie Durward, April Litchford, Catherine Hansen, Annette Prall, Caitlyn Jasumback

Outcomes and Impact Quarterly

Stakeholders sought to reduce the burden of preventable diabetes among adults in Utah via a “Food as Medicine” webinar series. The “Food as Medicine” webinar series sought to increase awareness of and enrollment in public diabetes programs. Evaluation results from the webinar series indicated an increase in awareness of diabetes programs and nutrition information needed to improve personal diabetes management.


Prevalence Of Health-Risk Behaviours Among Indigenous Australians With Diabetes: A Review, Sharon Atkinson-Briggs, Alicia Jenkins, Christopher Ryan, Laima Brazionis Sep 2022

Prevalence Of Health-Risk Behaviours Among Indigenous Australians With Diabetes: A Review, Sharon Atkinson-Briggs, Alicia Jenkins, Christopher Ryan, Laima Brazionis

Journal of the Australian Indigenous HealthInfoNet

Aboriginal and Torres Strait Islander Australians are at high risk of Type 2 diabetes and its complications. Optimal lifestyle choices can improve health outcomes. A thematic review of original research publications related to smoking, nutrition, alcohol intake, physical activity and emotional wellness in Aboriginal and Torres Strait Islander Australians with diabetes was performed. Overall, 7118 English-language publications were identified by search engines (PubMed, CINAHL, Scopus, Medline-Web of Science, and Google Scholar) with search terms Indigenous Australians OR Aboriginal and Torres Strait Islanders AND diabetes AND lifestyle OR smoking OR nutrition OR alcohol OR physical activity OR emotional wellbeing and their …


September 2022, Swosu Bulldog Wellness Committee Sep 2022

September 2022, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

National Childhood Obesity Awareness Month

About 1 in 5 American children has obesity. Compared to children with healthy weight, children with overweight or obesity are at a higher risk for asthma, sleep apnea, bone and joint problems, type 2 diabetes, and heart disease.


The Molecular Basis Of Diabetic Cardiomyopath, Ahmed Salaheldin Mustafa Ali Sultan Sep 2022

The Molecular Basis Of Diabetic Cardiomyopath, Ahmed Salaheldin Mustafa Ali Sultan

Dissertations

Diabetes mellitus (DM) is a major and worsening global health problem. Type 2 diabetes mellitus (T2DM) accounts for more than 90% of DM and the global epidemic of obesity largely explains the dramatic increase in the incidence and prevalence of T2DM over the past 20 years. Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The electrocardiogram (ECG) of diabetic and obese patients is frequently disturbed. The aim of this project was to characterize and clarify the molecular basis of electro-mechanical dysfunction in the hearts of type 2 diabetic and type 2 diabetic/obese rats. Experiments were …


Efficacy Of Various Interventions For Achieving Target Hba1c Levels For Patients With Type Ii Diabetes Mellitus And On Exogenous Insulin, Caitlin S. Welch, Archie Troxel Aug 2022

Efficacy Of Various Interventions For Achieving Target Hba1c Levels For Patients With Type Ii Diabetes Mellitus And On Exogenous Insulin, Caitlin S. Welch, Archie Troxel

Longitudinal Scholar's Project

Objective: To learn the rates at which patients at UT Family Medicine–St. Francis (UTFM–SF) with type II diabetes mellitus are being prescribed recommended medications—namely metformin, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and glucagon-like peptide 1 receptor agonists (GLP1RAs)—whether these rates correspond to the severity of hyperglycemia (as indicated by HbA1C level). A secondary goal of the study was to investigate if HbA1C levels are being checked at recommended intervals.

Methods: A retrospective chart review was conducted using records of patients seen at the clinic in the previous four years between the ages of 18 and 65 who had visits with ICD …


Diabetes Mellitus Type 2, Jyoti Adhikari Aug 2022

Diabetes Mellitus Type 2, Jyoti Adhikari

Nursing Student Class Projects (Formerly MSN)

Diabetes Mellitus is a metabolic disorder that affects millions of people. The trend continues to be upward. Youth and children are not exempt from this. It is a chronic metabolic disorder characterized by persistent hyperglycemia. Causes are impaired insulin secretion, resistance to the peripheral action of insulin, or both. There are three types of diabetes: type 1, type 2, and gestational. Type 2 DM accounts for around 90% of all cases of DM. In type 2 DM, the body's response to insulin diminishes causing insulin resistance. It is commonly seen in people older than 45 years old but increasingly seen …


Quantile Differences In The Age-Related Decline In Cardiorespiratory Fitness Between Sexes In Adults Without Type 2 Diabetes Mellitus In The United States, Andrew Ortaglia, Melissa Stansbury, Michael David Wirth, Xuemei Sui, Matteo Bottai Aug 2022

Quantile Differences In The Age-Related Decline In Cardiorespiratory Fitness Between Sexes In Adults Without Type 2 Diabetes Mellitus In The United States, Andrew Ortaglia, Melissa Stansbury, Michael David Wirth, Xuemei Sui, Matteo Bottai

Faculty Publications

Objective: To comprehensively assess the extent to which the decline in cardiorespiratory fitness (CRF) with age differs between sexes. Participants and Methods: This study used data from the Aerobics Center Longitudinal Study, conducted between September 1974 and August 2006, consisting primarily of White adults from middle-to-upper socioeconomic strata restricted to adults without type 2 diabetes mellitus (33,742 men and 9,415 women). Quantile regression models were used to estimate the differences in age-associated changes in CRF between the sexes, estimated using a maximal treadmill test. Results: For adults aged up to 45 years, significant differences in slopes relating to age and …


Estimating The Health Effects Of Adding Bicycle And Pedestrian Paths At The Census Tract Level: Multiple Model Comparison, Ross J. Gore, Christopher Lynch, Craig Jordan, Andrew Collins, R. Michael Robinson, Gabrielle Fuller, Pearson Ames, Prateek Keerthi, Yash Kandukuri Aug 2022

Estimating The Health Effects Of Adding Bicycle And Pedestrian Paths At The Census Tract Level: Multiple Model Comparison, Ross J. Gore, Christopher Lynch, Craig Jordan, Andrew Collins, R. Michael Robinson, Gabrielle Fuller, Pearson Ames, Prateek Keerthi, Yash Kandukuri

VMASC Publications

Background: Adding additional bicycle and pedestrian paths to an area can lead to improved health outcomes for residents over time. However, quantitatively determining which areas benefit more from bicycle and pedestrian paths, how many miles of bicycle and pedestrian paths are needed, and the health outcomes that may be most improved remain open questions.

Objective: Our work provides and evaluates a methodology that offers actionable insight for city-level planners, public health officials, and decision makers tasked with the question “To what extent will adding specified bicycle and pedestrian path mileage to a census tract improve residents’ health outcomes over time?” …


Whole Genome Sequence Association Analysis Of Fasting Glucose And Fasting Insulin Levels In Diverse Cohorts From The Nhlbi Topmed Program, Daniel Dicorpo, Sheila M. Gaynor, Emily M. Russell, Kenneth E. Westerman, Laura M. Raffield, Marcio Almeida, Juan M. Peralta, John Blangero, Joanne E. Curran, Ravindranath Duggirala Jul 2022

Whole Genome Sequence Association Analysis Of Fasting Glucose And Fasting Insulin Levels In Diverse Cohorts From The Nhlbi Topmed Program, Daniel Dicorpo, Sheila M. Gaynor, Emily M. Russell, Kenneth E. Westerman, Laura M. Raffield, Marcio Almeida, Juan M. Peralta, John Blangero, Joanne E. Curran, Ravindranath Duggirala

School of Medicine Publications and Presentations

The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen cohorts in NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program. Over 23,000 non-diabetic individuals from five race-ethnicities/populations (African, Asian, European, Hispanic and Samoan) were included. Eight variants were significantly associated with FG or FI across previously identified regions MTNR1B, G6PC2, GCK, GCKR and FOXA2. We additionally characterize suggestive associations with FG or FI near previously identified SLC30A8, TCF7L2, and ADCY5 regions as well …