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2002

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Articles 1 - 30 of 1724

Full-Text Articles in Medicine and Health Sciences

Income Inequality And Family Income And Their Relationships To Chronic Medical Conditions And Mental Health Disorders, Roland Sturm, Carole Gresenz Jan 2013

Income Inequality And Family Income And Their Relationships To Chronic Medical Conditions And Mental Health Disorders, Roland Sturm, Carole Gresenz

Roland Sturm

No abstract provided.


An Investigation Of The Interest For A Nurse Re-Entry Program In Southeastern Ohio, Marsha K. Rodgers Dec 2002

An Investigation Of The Interest For A Nurse Re-Entry Program In Southeastern Ohio, Marsha K. Rodgers

Theses, Dissertations and Capstones

In the United States and throughout the world there is a serious concern in the growing nursing shortage. Many recruitment and retention techniques are currently being used to ease the nursing shortage. One such avenue is a nurse re-entry program. The primary purpose of this study was to determine the interest for a RN re-entry program in southeastern Ohio.

The data collected during the investigation used both qualitative and quantitative research techniques. Information was received through two survey questionnaires and two focus groups. The instruments were designed with the purpose of determining how many registered nurses were not working in ...


Effect Of Assessment Method On The Discrepancy Between Judgments Of Health Disorders People Have And Do Not Have: A Web Study, Jonathan Baron, David A. Asch, Angela Fagerlin, Christopher A. Jepson, George Loewenstein, Jason Riis, Margaret G. Stineman, Peter A. Ubel Dec 2002

Effect Of Assessment Method On The Discrepancy Between Judgments Of Health Disorders People Have And Do Not Have: A Web Study, Jonathan Baron, David A. Asch, Angela Fagerlin, Christopher A. Jepson, George Loewenstein, Jason Riis, Margaret G. Stineman, Peter A. Ubel

Marketing Papers

Three experiments on the World Wide Web asked subjects to rate the severity of common health disorders such as acne or arthritis. People who had a disorder (“Haves”) tended to rate it as less severe than people who did not have it (“Not-haves”). Two explanations of this Have versus Not-have discrepancy were rejected. By one account, people change their reference point when they rate a disorder that they have. More precise reference points would, on this account, reduce the discrepancy, but, if anything, the discrepancy was larger. By another account, people who do not have the disorder focus on attributes ...


Viability Of A Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights For Better Antiviral Therapy, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Nancy M. King, Celia A. Schiffer Dec 2002

Viability Of A Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights For Better Antiviral Therapy, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Nancy M. King, Celia A. Schiffer

Open Access Publications by UMass Chan Authors

Under the selective pressure of protease inhibitor therapy, patients infected with human immunodeficiency virus (HIV) often develop drug-resistant HIV strains. One of the first drug-resistant mutations to arise in the protease, particularly in patients receiving indinavir or ritonavir treatment, is V82A, which compromises the binding of these and other inhibitors but allows the virus to remain viable. To probe this drug resistance, we solved the crystal structures of three natural substrates and two commercial drugs in complex with an inactive drug-resistant mutant (D25N/V82A) HIV-1 protease. Through structural analysis and comparison of the protein-ligand interactions, we found that Val82 interacts ...


Regulation Of Rac1 Activation By The Low Density Lipoprotein Receptor–Related Protein, Zhong Ma, Keena S. Thomas, Donna J. Webb, Radim Moravec, Ana Maria Salicioni, Wendy M. Mars, Steven L. Gonias Dec 2002

Regulation Of Rac1 Activation By The Low Density Lipoprotein Receptor–Related Protein, Zhong Ma, Keena S. Thomas, Donna J. Webb, Radim Moravec, Ana Maria Salicioni, Wendy M. Mars, Steven L. Gonias

Ana Maria Salicioni

The low density lipoprotein receptor–related protein (LRP-1) binds and mediates the endocytosis of multiple ligands, transports the urokinase-type plasminogen activator receptor (uPAR) and other membrane proteins into endosomes, and binds intracellular adaptor proteins involved in cell signaling. In this paper, we show that in murine embryonic fibroblasts (MEFs) and L929 cells, LRP-1 functions as a major regulator of Rac1 activation, and that this activity depends on uPAR. LRP-1–deficient MEFs demonstrated increased Rac1 activation compared with LRP-1–expressing MEFs, and this property was reversed by expressing the VLDL receptor, a member of the same gene family as LRP-1, with ...


Autoantibodies To Centrosomes Are Diagnostic For Human Scleroderma And Can Be Induced By Experimental Mycoplasma Infection In Mice: A Dissertation, Irina Catrinel Gavanescu Dec 2002

Autoantibodies To Centrosomes Are Diagnostic For Human Scleroderma And Can Be Induced By Experimental Mycoplasma Infection In Mice: A Dissertation, Irina Catrinel Gavanescu

Morningside Graduate School of Biomedical Sciences Dissertations and Theses

The overall objective of this thesis work was to develop new insights into the etiology of scleroderma, a human systemic autoimmune disease, by analyzing the autoantibodies to centrosome antigens that develop during the disease. Centrosomes are perinuclear organelles that form microtubule arrays, including mitotic spindles that ensure the faithful segregation of chromosomes during mitosis.

These studies used a novel methodology to determine the prevalence of anti-centrosome autoantibodies in patients with scleroderma. Recombinant centrosome antigens were used to determine the antigenic specificity of anti-centrosome antibody subsets by immunoblotting. Centrosome marker antibodies were used in indirect immunofluorescence assays to distinguish centrosomes within ...


Method For Inhibition Of Photocarcinogenesis Or Photoimmunosuppression Using Niacin, Elaine L. Jacobson, Helen L. Gensler Dec 2002

Method For Inhibition Of Photocarcinogenesis Or Photoimmunosuppression Using Niacin, Elaine L. Jacobson, Helen L. Gensler

Graduate Center for Nutritional Sciences Faculty Patents

The invention is directed to novel methods for the suppression of photocarcinogenesis and photoimmunosuppression in mice. The novel methods comprises the step of administering to a subject a pharmaceutical composition comprising niacin and a pharmaceutical carrier.


Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks Dec 2002

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.


Migrant Worker Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center Dec 2002

Migrant Worker Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On September 13, 2002, a 26 year-old male Hispanic migrant worker (decedent) died when the tractor he was driving on a country roadway overturned. The decedent had experience driving the tractor in a field, but did not have experience driving it on a public roadway. On the afternoon of the incident, the decedent drove the tractor, pulling a wagonload of tobacco, from the farm where it had been harvested to the tobacco barn one mile away. The road was hilly and had a sharp curve to the right at the bottom of the hill. As the decedent drove the tractor ...


Screening At Worksite Applying The Framingham Heart Study Score., Paulo A. Lotufo Dec 2002

Screening At Worksite Applying The Framingham Heart Study Score., Paulo A. Lotufo

Paulo A Lotufo

The first evaluation of class of occupation and cardiovascular risk factors in a Brazilian sample of civil servants. 1) context: Cardiovascular diseases are the main causes of death in Brazil. The high-risk approach to cardiovascular risk factors by screening test at worksite is one possible strategy of prevention. 2) objective: to verify the impact of a risk factors screening according to occupational levels. 3) type of study: cross-sectional 4) setting: occupational division of University of Sao Paulo 5) participants: 6,587 employees aged 20 to 69 years-old classified according three occupational grades (non-skilled, both manual and non-manual jobs; technical; faculty ...


Feline Immunodeficiency Virus Integration In B-Cell Lymphoma Identifies A Candidate Tumor Suppressor Gene On Human Chromosome 15q151, Julia Beatty, Anne Terry, Julie Macdonald, Elizabeth Gault, Stanley Cevario, Stephen J. O'Brien, Ewan Cameron, James C. Neil Dec 2002

Feline Immunodeficiency Virus Integration In B-Cell Lymphoma Identifies A Candidate Tumor Suppressor Gene On Human Chromosome 15q151, Julia Beatty, Anne Terry, Julie Macdonald, Elizabeth Gault, Stanley Cevario, Stephen J. O'Brien, Ewan Cameron, James C. Neil

Biology Faculty Articles

Infection with immunosuppressive lentiviruses is associated with increased cancer risk,but most studies have implicated indirect mechanisms as the tumor cells generally lack integrated viral sequences.An exception wasfound in a B-cell lymphoma (Q254) where the tumor cells contained a single integrated feline immunodeficiency virus genome. Additional analysis now indicates that feline immunodeficiency virus integration in lymphoma Q254 resulted in promoter insertion and truncation of a conserved gene on feline chromosome B3, whereas the unaffected allele of the gene appeared to be transcriptionally down-regulated. The orthologous human gene (FLJ12973), is expressed ubiquitously and encodes a WD-repeat protein with structural similarity ...


Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson Dec 2002

Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson

Electronic Theses and Dissertations

Lithium continues to be widely prescribed for the management of bipolar disease, yet cognitive impairment-related side effects promote noncompliance of the treatment regimen. We have introduced a novel animal model, the black molly fish, to study dose-response effects of lithium on short-term (STM) and long-term (LTM) memories. We developed a method utilizing capillary ion analysis (CIA), to measure plasma and brain lithium levels employed in our behavioral studies. We then developed an appropriate testing environment to ascertain learning capacities of these fish. We established that black mollies could adequately perform a forced-choice spontaneous alternation (SA) task used extensively in rodents ...


Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin Dec 2002

Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin

Electronic Theses and Dissertations

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated membrane K+ current. Patch-clamp electrophysiology and transwell migration assays were used to study the effects of HGF/SF on membrane K+ currents and cell migration in MDCK II cells. HGF/SF activated membrane K+ currents that increased over 24 hr, and these could be modulated by altering intracellular free calcium ...


R&D Is How Best Companies Stay That Way, Rick Burton Dec 2002

R&D Is How Best Companies Stay That Way, Rick Burton

Sport Management

No abstract provided.


Activation And Role Of Memory Cd8 T Cells In Heterologous Antiviral Immunity And Immunopathology In The Lung: A Dissertation, Hong Chen Dec 2002

Activation And Role Of Memory Cd8 T Cells In Heterologous Antiviral Immunity And Immunopathology In The Lung: A Dissertation, Hong Chen

Morningside Graduate School of Biomedical Sciences Dissertations and Theses

Each individual experiences many sequential infections throughout the lifetime. An increasing body of work indicates that prior exposure to unrelated pathogens can greatly alter the disease course during a later infection. This can be a consequence of a phenomenon known as heterologous immunity. Most viruses invade the host through the mucosa of a variety of organs and tissues. Using the intranasal mucosal route of infection, the thesis focused on studying modulation of lymphocytic choriomeningitis virus (LCMV)-specific memory CD8 T cells upon respiratory vaccinia virus (VV) infection and the role of these memory CD8 T cells in heterologous immunity against ...


Sommerville, Bonnie Interview For The Miami Valley College Of Nursing And Health Oral History Project, Donna M. Curry, Carol Holdcraft, Bonnie Sommerville Dec 2002

Sommerville, Bonnie Interview For The Miami Valley College Of Nursing And Health Oral History Project, Donna M. Curry, Carol Holdcraft, Bonnie Sommerville

Wright State University - Miami Valley College of Nursing and Health Oral History Project

Carol Holdcraft and Donna Miles Curry interviewed Bonnie Sommerville on December 3, 2002 about the founding of Wright State University College of Nursing and Health. In the interview, Sommerville discusses her career and her decision to come to Wright State as a student and faculty member for the College of Nursing and Health.


Satisfaction Of Orthognathic Surgical Patients In A Malaysian Population, K. K. Siow, S. T. Ong, C. B. Lian, W.C. Ngeow Dec 2002

Satisfaction Of Orthognathic Surgical Patients In A Malaysian Population, K. K. Siow, S. T. Ong, C. B. Lian, W.C. Ngeow

Wei Cheong Ngeow

Thirty-one patients treated at the Faculty of Dentistry, University of Malaya, were assessed for their satisfaction following orthognathic surgery. The female to male ratio was 22:9 with an age range of 17 to 36. Almost all patients (97%) listed appearance as one of their rationales for surgery. More males (78%) than females (59%) wanted functional improvement, while more females (91%) than males (33%) hoped for improvement in self-confidence. All patients reported esthetic improvement while 68% each reported improvement in mastication and self-confidence. Slightly more than half (52%) chose esthetic improvement as the single most important factor resulting in satisfaction ...


Orthognathic Surgery In The University Of Malaya, W.C. Ngeow, S. T. Ong, K. K. Siow, C. B. Ian Dec 2002

Orthognathic Surgery In The University Of Malaya, W.C. Ngeow, S. T. Ong, K. K. Siow, C. B. Ian

Wei Cheong Ngeow

This is the first review on orthognathic surgery in Malaysia. The records of a total of 84 patients seen between 1977 and 1999 in the Department of Oral and Maxillofacial Surgery of the Faculty of Dentistry, University of Malaya were analysed. Skeletal III deformity formed 85% of the sample with a female dominance of 2 to 1. The patients' age ranged from 17 to 36 years, with a mean of 25.3 years. The common surgical techniques used were combined bilateral sagittal split and Le Fort I osteotomy. The predominant ethnic group was Chinese (n=58, 69%); followed by Malay ...


Predicting The Readability Of Transparent Text, Lauren F. V. Scharff, Albert J. Ahumada Jr. Dec 2002

Predicting The Readability Of Transparent Text, Lauren F. V. Scharff, Albert J. Ahumada Jr.

Faculty Publications

Will a simple global masking model based on image detection be successful at predicting the readability of transparent text? Text readability was measured for two types of transparent text: additive (as occurs in head-up displays) and multiplicative (which occurs in see-through liquid crystal display virtual reality displays). Text contrast and background texture were manipulated. Data from two previous experiments were also included (one using very low contrasts on plain backgrounds, and the other using higher-contrast opaque text on both plain and textured backgrounds). All variables influenced readability in at least an interactive manner. When there were background textures, the global ...


Rac-1 And Iqgap Are Potential Regulators Of E-Cadherin-Catenin Interactions During Murine Preimplantation Development., David R Natale, Andrew J Watson Dec 2002

Rac-1 And Iqgap Are Potential Regulators Of E-Cadherin-Catenin Interactions During Murine Preimplantation Development., David R Natale, Andrew J Watson

Obstetrics & Gynaecology Publications

Adherens junction formation is fundamental for compaction and trophectoderm differentiation during mammalian preimplantation development. We recently isolated an IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine preimplantation developmental stages. IQGAP-1 and -2 proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation development. IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage.


Urinary Excretion Of Dithiocarbamates And Selfreported Cruciferous Vegetable Intake: Application Of The ‘Method Of Triads’ To A Foodspecific Biomarker, Jay H. Fowke, James R. Hébert, Jed W. Fahey Dec 2002

Urinary Excretion Of Dithiocarbamates And Selfreported Cruciferous Vegetable Intake: Application Of The ‘Method Of Triads’ To A Foodspecific Biomarker, Jay H. Fowke, James R. Hébert, Jed W. Fahey

Faculty Publications

Objective: Greater intake of Cruciferous vegetables (e.g. broccoli) may prevent cancer at several sites. Urinary excretion of isothiocyanate conjugates (dithiocarbamates, DTC) provides a specific biomarker of Cruciferous vegetable consumption suitable for epidemiological investigations. However, no gold-standard referent is available for evaluating urinary DTC levels as an estimator of Cruciferous vegetable consumption. We compared urinary DTC levels to intake as measured by two selfreported dietary assessment techniques. Design: Cruciferous vegetable consumption was measured before and after a behavioural dietary intervention using multiple 24-hour recalls (24HR), a foodcounting questionnaire (VFQ) and urinary DTC excretion levels. Analysis included a structural equation approach ...


District Hospital Based Injury Data-Are They An Option In A Developing Country?, Junaid Abdul Razzak, David Marsh, S. Stansfield Dec 2002

District Hospital Based Injury Data-Are They An Option In A Developing Country?, Junaid Abdul Razzak, David Marsh, S. Stansfield

Department of Emergency Medicine

No abstract provided.


What's Happening: December, 2002, Maine Medical Center Dec 2002

What's Happening: December, 2002, Maine Medical Center

What's Happening

No abstract provided.


Influence Of Moderate Training On Gait And Work Capacity In Fibromyalgia Patients: A Preliminary Field Study, Peter Tiidus, Michael Pierrynowski, Kimberley A. Dawson Dec 2002

Influence Of Moderate Training On Gait And Work Capacity In Fibromyalgia Patients: A Preliminary Field Study, Peter Tiidus, Michael Pierrynowski, Kimberley A. Dawson

Kinesiology and Physical Education Faculty Publications

This field study examined the influence of moderate intensity training on gait patterns and work capacity of individauls with fibromyalgia syndrome (FS). FS is a chronic condition of unknown etiology, characterized by muscle tenderness, pain and stiffness and often accompanied by depression and fatigue which seems to occur primarily in middle aged females. There is no known cure for FS but treatment often includes a prescription of mild exercise. Few studies have evaluated the effectiveness of mild exercise on work capacity and gait patterns in FS patients. Participants were 14 females (age 47.0±7.6 y) who participated in ...


Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002 Dec 2002

Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002 Dean's Column by Dean Thomas J. Nasca ’75, page 4 New Chairman of Medicine Art Feldman, page 6 Rao, Buchheit, Siegman, Wender Are Appointed Chairs, page 9 Emergency Medicine Is Made a Department, page 11 Hospital Is Named as the Best in Philadelphia, page 11 Technology Transfer in the 21st Century, page 12 In Kenya, Jeff Students Reach the Underserved, page 14 African Americans' Satisfaction with Medical Careers, page 15 Ana Maria Lopez '88: Reaching Out via Telemedicine, page 22 New Consolidation Rates for Student Borrowers, page 23 Monica Morrow ...


Isolation And Investigation Of The Exopolysaccharide From Thauera Sp. Mz1t, Michael S. Allen Dec 2002

Isolation And Investigation Of The Exopolysaccharide From Thauera Sp. Mz1t, Michael S. Allen

Doctoral Dissertations

Thauera sp. strain MZ1T is a floc-forming bacterium isolated from the wastewater treatment plant of Eastman Chemical Company. Its overabundance in that system in the form of zoogloeal clusters was positively correlated to episodes of poor dewatering of activated sludge (Lajoie 2000). The specific cause of this problem was thought to be due to the production of large quantities of hydrophilic exopolysaccharide (EPS) by MZ1T, which entraps water in the form of a hydrated gel, and results in a sludge that is resistant to mechanical dewatering.

A method for the reproducible extraction of EPS from pure cultures of MZ1T was ...


“Private” Crime In Public Housing: Violent Victimization, Fear Of Crime And Social Isolation Among Women Public Housing Residents, Claire M. Renzetti, Shana L. Maier Dec 2002

“Private” Crime In Public Housing: Violent Victimization, Fear Of Crime And Social Isolation Among Women Public Housing Residents, Claire M. Renzetti, Shana L. Maier

CRVAW Faculty Journal Articles

Although public housing is typically associated with high crime rates, little research has been done on fear of crime or violent victimization experiences among public housing residents. Moreover, there are few studies that look specifically at women’s fear of crime or violent victimization experiences in public housing, despite the fact that women constitute the majority of public housing residents. These issues were examined in the present study through interviews with female public housing residents in Camden, New Jersey (NJ). The interviews reveal high rates of violent victimization, especially at the hands of intimates and acquaintances. Fear of crime is ...


A Conceptual Model For Capacity Building In Australian Primary Health Care Research, Elizabeth Farmer, Kathryn M. Weston Dec 2002

A Conceptual Model For Capacity Building In Australian Primary Health Care Research, Elizabeth Farmer, Kathryn M. Weston

Graduate School of Medicine - Papers (Archive)

Background: Many general practitioners and primary health care practitioners lack research and evaluation skills. In response, the Australian Government has funded important capacity building initiatives.

Aim: To propose a conceptual model to assist these initiatives.

Model: Four groups of research involvement are suggested: nonparticipants; participating (as part of a research team); managing/training (either leading research, or in formal training to do so); and academic (with, or leading toward, a doctorate). We outline six guiding principles for research capacity building: 1) a whole system approach, 2) accommodating diversity, 3) reducing barriers to participation, 4) enabling collaboration, 5) mentoring, and 6 ...


Human Subjects Protection In Research: Are We Doing Enough?, Marsha L. Green Dec 2002

Human Subjects Protection In Research: Are We Doing Enough?, Marsha L. Green

UNLV Theses, Dissertations, Professional Papers, and Capstones

Scientific research has produced substantial social benefits but has also posed troubling ethical questions with regard to the use and protection of human subjects. These questions have continued to be in the forefront of all biomedical and social research. The increased education of researchers on the subject of protection of human subjects has become of vital importance in the research world. This education involves program administrators, faculty, staff, students, research participants, and Institutional Review Board Committee (IRB) members. In this study of the University of Nevada, LasVegas (UNLV) human subjects’ protection program administration, the question to be answered was: has ...


Arkansas Animal Science Department Report 2002, Zelpha B. Johnson, D. Wayne Kellogg Dec 2002

Arkansas Animal Science Department Report 2002, Zelpha B. Johnson, D. Wayne Kellogg

Arkansas Agricultural Experiment Station Research Series

No abstract provided.