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Articles 1 - 30 of 4720

Full-Text Articles in Medicine and Health Sciences

Small Extracellular Vesicle-Mediated Itgb6 Sirna Delivery Downregulates The Αvβ6 Integrin And Inhibits Adhesion And Migration Of Recipient Prostate Cancer Cells, Shiv Ram Krishn, Vaughn Garcia, Nicole M Naranjo, Fabio Quaglia, Christopher D Shields, Maisha A Harris, Andrew V Kossenkov, Qin Liu, Eva Corey, Dario C Altieri, Lucia R Languino Dec 2022

Small Extracellular Vesicle-Mediated Itgb6 Sirna Delivery Downregulates The Αvβ6 Integrin And Inhibits Adhesion And Migration Of Recipient Prostate Cancer Cells, Shiv Ram Krishn, Vaughn Garcia, Nicole M Naranjo, Fabio Quaglia, Christopher D Shields, Maisha A Harris, Andrew V Kossenkov, Qin Liu, Eva Corey, Dario C Altieri, Lucia R Languino

Department of Cancer Biology Faculty Papers

The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of ITGB6 (encoding the β6 integrin subunit) are significantly increased in metastatic castrate-resistant androgen receptor-negative prostate tumors compared to androgen receptor-positive prostate tumors. In addition, the αVβ6 integrin protein levels are significantly elevated in androgen receptor-negative PrCa patient derived xenografts (PDXs) compared to androgen receptor-positive PDXs. In vitro, the androgen receptor-negative PrCa cells express high levels of the αVβ6 integrin compared to androgen receptor-positive PrCa cells. Additionally, expression ...


Reducing The Risk Of Chemotherapy Exposure, Miranda Susman Dec 2022

Reducing The Risk Of Chemotherapy Exposure, Miranda Susman

Symposium of Student Scholars

Concerns about antineoplastic drugs (ANPDs), also known as chemotherapy, began in the early 1970s by the National Institute for Occupational Safety and Health. Although ANPDs are used as a standard treatment for cancer, these drugs are considered hazardous due to their adverse health effects. About eight million healthcare workers are exposed to ANPDs and therefore essential that we continue to educate on ways to reduce the risk of exposure to occupational and home health hazards. The overall purpose of this study is to determine if additional education and use of surface wipe samplings reduce the risk of exposure. A literature ...


Indwelling Pleural Catheterization Maximizes Functionality And Quality Of Life In Management Of Recurrent Malignant Pleural Effusions, Avinash Ramkissoon Dec 2022

Indwelling Pleural Catheterization Maximizes Functionality And Quality Of Life In Management Of Recurrent Malignant Pleural Effusions, Avinash Ramkissoon

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Davies HE, Mishra EK, Kahan BC, et al. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: The TIME2 randomized controlled trial. J Am Med Assoc. 2012;307(22):2383-2389. https://doi.org/10.1001/jama.2012.5535

for the management of recurrent malignant pleural effusions in a patient with metastatic renal cell carcinoma.


A National Multi-Institutional Analysis Of Predictors Of Surgical Site Complications And Unplanned Reoperation After Paramedian Forehead Flap Reconstruction, Garrett Ni, Rohan Brebion, Pablo A. Baltodano, Michael C. Coronado, Nicholas Elmer, Theresa K. Webster, Huaqing Zhao, Xiaoning Lu, Sthefano Araya, Sameer Patel Dec 2022

A National Multi-Institutional Analysis Of Predictors Of Surgical Site Complications And Unplanned Reoperation After Paramedian Forehead Flap Reconstruction, Garrett Ni, Rohan Brebion, Pablo A. Baltodano, Michael C. Coronado, Nicholas Elmer, Theresa K. Webster, Huaqing Zhao, Xiaoning Lu, Sthefano Araya, Sameer Patel

Student Papers & Posters

Background: Although postoperative complications of paramedian forehead flap (PMFF) are generally low, surgical site complications and unplanned reoperation can still occur. Recent literature suggests infection to be the most common complication following PMFF reconstruction. This study sought to determine the patient and preoperative factors associated with surgical site complications and unplanned reoperations at a national level.

Methods: Patients who underwent PMFF reconstruction from the ACS-NSQIP 2007 - 2019 database were analyzed to determine composite surgical site morbidity and unplanned return to the operating room. Patient and operative factors were also analyzed to assess independent risk factors for surgical site morbidity and ...


Conducting A Supportive Oncology Clinical Trial During The Covid-19 Pandemic: Challenges And Strategies, Jie Deng, John N. Lukens, Joy C. Cohn, Erin Mcmenamin, Barbara Murphy, Bryan A. Spinelli, Niya Murphy, Alicia K. Steinmetz, Megan A. Landriau, Alexander Lin Nov 2022

Conducting A Supportive Oncology Clinical Trial During The Covid-19 Pandemic: Challenges And Strategies, Jie Deng, John N. Lukens, Joy C. Cohn, Erin Mcmenamin, Barbara Murphy, Bryan A. Spinelli, Niya Murphy, Alicia K. Steinmetz, Megan A. Landriau, Alexander Lin

Department of Physical Therapy Faculty Papers

The coronavirus disease 2019 (COVID-19) pandemic resulted in severe interruptions to clinical research worldwide. This global public health crisis required investigators and researchers to rapidly develop and implement new strategies and solutions to mitigate its negative impact on the progress of clinical trials. In this paper, we describe the challenges, strategies, and lessons learned regarding the continuation of a supportive oncology clinical trial during the pandemic. We hope to provide insight into the implementation of clinical trials during a public health emergency to be better prepared for future instances.

Trial registration: ClinicalTrials.gov, a service of the US National Institute ...


Emerging Role Of Autologous Cd19 Car T-Cell Therapies In The Second-Line Setting For Large B-Cell Lymphoma: A Game Changer?, Razan Mohty, Muhamad A. Moustafa, Mahmoud Aljurf, Hemant Murthy, Mohamed A. Kharfan-Dabaja Nov 2022

Emerging Role Of Autologous Cd19 Car T-Cell Therapies In The Second-Line Setting For Large B-Cell Lymphoma: A Game Changer?, Razan Mohty, Muhamad A. Moustafa, Mahmoud Aljurf, Hemant Murthy, Mohamed A. Kharfan-Dabaja

Hematology/Oncology and Stem Cell Therapy

Chimeric antigen receptor T-cell (CAR T) therapy has been proven effective in the third-line (and beyond) setting in patients with large B-cell lymphoma (LBCL). Until recently, high-dose chemotherapy followed by autologous hematopoietic cell transplantation (auto-HCT) was considered the standard of care in the second-line setting in patients demonstrating an objective response before the procedure. The ZUMA-7 and TRANSFORM studies showed the benefit of axicabtagene ciloleucel and lisocabtagene maraleucel, respectively, in patients refractory to or relapsing within 12 months of first-line anthracycline-based chemoimmunotherapy. However, a third trial using tisagenlecleucel failed to show a benefit in the same setting compared to standard ...


The Nogo Receptor Ngr2, A Novel Αvβ3 Integrin Effector, Induces Neuroendocrine Differentiation In Prostate Cancer, Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter Mccue, Andrew V. Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, Lucia R. Languino Nov 2022

The Nogo Receptor Ngr2, A Novel Αvβ3 Integrin Effector, Induces Neuroendocrine Differentiation In Prostate Cancer, Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter Mccue, Andrew V. Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, Lucia R. Languino

Department of Cancer Biology Faculty Papers

Androgen deprivation therapies aimed to target prostate cancer (PrCa) are only partially successful given the occurrence of neuroendocrine PrCa (NEPrCa), a highly aggressive and highly metastatic form of PrCa, for which there is no effective therapeutic approach. Our group has demonstrated that while absent in prostate adenocarcinoma, the αVβ3 integrin expression is increased during PrCa progression toward NEPrCa. Here, we show a novel pathway activated by αVβ3 that promotes NE differentiation (NED). This novel pathway requires the expression of a GPI-linked surface molecule, NgR2, also known as Nogo-66 receptor homolog 1. We show here that NgR2 is upregulated by αVβ3 ...


Metformin Increases Natural Killer Cell Functions In Head And Neck Squamous Cell Carcinoma Through Cxcl1 Inhibition, Mckenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A. Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M. Wise-Draper Nov 2022

Metformin Increases Natural Killer Cell Functions In Head And Neck Squamous Cell Carcinoma Through Cxcl1 Inhibition, Mckenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A. Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M. Wise-Draper

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

BACKGROUND: Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial (NCT02325401). Metformin is also postulated to activate an antitumor immune response. Here, we investigate immunologic effects of metformin on natural killer (NK) and natural killer T cells, including results from two phase I open-label studies in patients with HNSCC treated with metformin (NCT02325401, NCT02083692).

METHODS: Peripheral blood was collected before and after metformin treatment or from newly diagnosed patients with HNSCC. Peripheral immune cell ...


Modification Of The Tumor Microenvironment Enhances Anti-Pd-1 Immunotherapy In Metastatic Melanoma, Guilan Shi, Megan Scott, Cathryn G. Mangiamele, Richard Heller Nov 2022

Modification Of The Tumor Microenvironment Enhances Anti-Pd-1 Immunotherapy In Metastatic Melanoma, Guilan Shi, Megan Scott, Cathryn G. Mangiamele, Richard Heller

Bioelectrics Publications

Resistance to checkpoint-blockade treatments is a challenge in the clinic. Both primary and acquired resistance have become major obstacles, greatly limiting the long-lasting effects and wide application of blockade therapy. Many patients with metastatic melanoma eventually require further therapy. The absence of T-cell infiltration to the tumor site is a well-accepted contributor limiting immune checkpoint inhibitor efficacy. In this study, we combined intratumoral injection of plasmid IL-12 with electrotransfer and anti-PD-1 in metastatic B16F10 melanoma tumor model to increase tumor-infiltrating lymphocytes and improve therapeutic efficacy. We showed that effective anti-tumor responses required a subset of tumor-infiltrating CD8+ and CD4+ T ...


Cancer Research Across Africa: A Comparative Bibliometric Analysis, Miriam Mutebi, Grant Lewison, Ajay Aggarwal, Olusegun Isaac Alatise, Christopher Booth, Miska Cira, Surbhi Grover, Ophira Ginsburg, Julie Gralow, Serine Gueye Nov 2022

Cancer Research Across Africa: A Comparative Bibliometric Analysis, Miriam Mutebi, Grant Lewison, Ajay Aggarwal, Olusegun Isaac Alatise, Christopher Booth, Miska Cira, Surbhi Grover, Ophira Ginsburg, Julie Gralow, Serine Gueye

General Surgery, East Africa

Introduction Research is a critical pillar in national cancer control planning. However, there is a dearth of evidence for countries to implement affordable strategies. The WHO and various Commissions have recommended developing stakeholder-based needs assessments based on objective data to generate evidence to inform national and regional prioritisation of cancer research needs and goals.

Methodology Bibliometric algorithms (macros) were developed and validated to assess cancer research outputs of all 54 African countries over a 12-year period (2009–2020). Subanalysis included collaboration patterns, site and domain-specific focus of research and understanding authorship dynamics by both position and sex. Detailed subanalysis was ...


Editorial: Novel Mechanisms For The Treatment Of Aml Before And After Transplant, Margaret T Kasner Oct 2022

Editorial: Novel Mechanisms For The Treatment Of Aml Before And After Transplant, Margaret T Kasner

Department of Medical Oncology Faculty Papers

No abstract provided.


Oncology Referral To Chemotherapy Initiation: Improving Timely Access To Care In Infusion Clinic, Kathy A. Keener Oct 2022

Oncology Referral To Chemotherapy Initiation: Improving Timely Access To Care In Infusion Clinic, Kathy A. Keener

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.


Prostate Imaging Reporting And Data System Score (Pi-Rads) And Glutathione S-Transferase P1 Methylation Status (Gst-P1) In The Diagnosis Of Prostate Cancer Patients With Borderline Psa Values, Marius Stan, Vladimir Botnarciuc, Andra Iulia Suceveanu, Andreea Cristina Costea, Adrian Paul Suceveanu, Laura Mazilu, Ciprian Iorga, Tony Hangan, Corneliu Tudor, Dragos Epistatu, Sergiu Chirila, Viorel Gherghina, Felix Voinea Oct 2022

Prostate Imaging Reporting And Data System Score (Pi-Rads) And Glutathione S-Transferase P1 Methylation Status (Gst-P1) In The Diagnosis Of Prostate Cancer Patients With Borderline Psa Values, Marius Stan, Vladimir Botnarciuc, Andra Iulia Suceveanu, Andreea Cristina Costea, Adrian Paul Suceveanu, Laura Mazilu, Ciprian Iorga, Tony Hangan, Corneliu Tudor, Dragos Epistatu, Sergiu Chirila, Viorel Gherghina, Felix Voinea

Journal of Mind and Medical Sciences

Objectives. The objective of this study was to evaluate the potential use of Prostate Imaging – Reporting and Data System version 2 (PI-RADS) in combination with Glutathione S-transferase P1 (GST-P1) expression for an improved diagnosis of prostate cancer, in patients with inconclusive values of prostate-specific antigen (PSA). Materials and Methods. The study was conducted on 80 patients for whom PSA values were evaluated and were found to be inconclusive (4-10 ng/ml). These patients underwent imagistic evaluation (PI-RADS), followed by transurethral prostate biopsy, with the evaluation of GST-P1 expression and histopathological examination (for diagnosis confirmation). Results. By combining the results of ...


A Machine Learning Model Of Response To Hypomethylating Agents In Myelodysplastic Syndromes, Nathan Radakovich, David A. Sallman, Rena Buckstein, Andrew Brunner, Amy Dezern, Sudipto Mukerjee, Rami Komrokji, Najla Al-Ali, Jacob Shreve, Yazan Rouphail, Anne Parmentier, Alexandre Mamedov, Mohammed Siddiqui, Yihong Guan, Teodora Kuzmanovic, Metis Hasipek, Babal Jha, Jaroslaw P. Maciejewski, Mikkael A. Sekeres, Aziz Nazha Oct 2022

A Machine Learning Model Of Response To Hypomethylating Agents In Myelodysplastic Syndromes, Nathan Radakovich, David A. Sallman, Rena Buckstein, Andrew Brunner, Amy Dezern, Sudipto Mukerjee, Rami Komrokji, Najla Al-Ali, Jacob Shreve, Yazan Rouphail, Anne Parmentier, Alexandre Mamedov, Mohammed Siddiqui, Yihong Guan, Teodora Kuzmanovic, Metis Hasipek, Babal Jha, Jaroslaw P. Maciejewski, Mikkael A. Sekeres, Aziz Nazha

Department of Medical Oncology Faculty Papers

Hypomethylating agents (HMA) prolong survival and improve cytopenias in individuals with higher-risk myelodysplastic syndrome (MDS). Only 30-40% of patients, however, respond to HMAs, and responses may not occur for more than 6 months after HMA initiation. We developed a model to more rapidly assess HMA response by analyzing early changes in patients’ blood counts. Three institutions’ data were used to develop a model that assessed patients’ response to therapy 90 days after the initiation using serial blood counts. The model was developed with a training cohort of 424 patients from2 institutions and validated on an independent cohort of 90 patients ...


Should Health Systems Share Genetic Findings With At-Risk Relatives When The Proband Is Deceased? Interviews With Individuals Diagnosed With Lynch Syndrome, Jessica Ezzell Hunter, Jennifer L. Schneider, Alison J. Firemark, James V. Davis, Sara Gille, Pamala A. Pawloski, Su-Ying Liang, Victoria Schlieder, Alanna Kulchak Rahm Oct 2022

Should Health Systems Share Genetic Findings With At-Risk Relatives When The Proband Is Deceased? Interviews With Individuals Diagnosed With Lynch Syndrome, Jessica Ezzell Hunter, Jennifer L. Schneider, Alison J. Firemark, James V. Davis, Sara Gille, Pamala A. Pawloski, Su-Ying Liang, Victoria Schlieder, Alanna Kulchak Rahm

Journal of Patient-Centered Research and Reviews

Purpose: Genetic information has health implications for patients and their biological relatives. Death of a patient before sharing a genetic diagnosis with at-risk relatives is a missed opportunity to provide important information that could guide interventions to minimize cancer-related morbidity and mortality in relatives.

Methods: We performed semi-structured interviews with individuals diagnosed with Lynch syndrome at 1 of 4 health systems to explore their perspectives on whether health systems should share genetic risk information with relatives following a patient’s death. An inductive, open-coding approach was used to analyze audio-recorded content, with software-generated code reports undergoing iterative comparative analysis by ...


Presentation And Predictors Of Metastatic Testicular Cancer: A Contemporary Population-Based Analysis, Yash Shah, Hanan Goldberg, Thenappan Chandrasekar Oct 2022

Presentation And Predictors Of Metastatic Testicular Cancer: A Contemporary Population-Based Analysis, Yash Shah, Hanan Goldberg, Thenappan Chandrasekar

Student Papers & Posters

Introduction

  • Testicular cancer (TC) is the most common solid malignancy in males aged 14-44, with incidence rising globally, although there are few established risk factors besides cryptorchidism.
  • While 70% of men present with localized TC, 18% have regional spread and 12% have metastases. Moreover, one-third of patients diagnosed with Stage I TC actually have occult metastases.


Ctpathway: A Crosstalk-Based Pathway Enrichment Analysis Method For Cancer Research, Haizhou Liu, Mengqin Yuan, Ramkrishna Mitra, Xu Zhou, Min Long, Wanyue Lei, Shunheng Zhou, Yu-E Huang, Fei Hou, Christine M. Eischen, Wei Jiang Oct 2022

Ctpathway: A Crosstalk-Based Pathway Enrichment Analysis Method For Cancer Research, Haizhou Liu, Mengqin Yuan, Ramkrishna Mitra, Xu Zhou, Min Long, Wanyue Lei, Shunheng Zhou, Yu-E Huang, Fei Hou, Christine M. Eischen, Wei Jiang

Department of Cancer Biology Faculty Papers

Background: Pathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways. Moreover, different pathways exert their functions through crosstalk. However, existing PEA methods do not sufficiently integrate essential pathway features, including pathway crosstalk, molecular interactions, and network topologies, resulting in many risk pathways that remain uninvestigated.

Methods: To overcome these limitations, we develop a new crosstalk-based PEA method, CTpathway, based on a global pathway crosstalk map (GPCM) with >440,000 edges by combing pathways from eight resources, transcription factor-gene regulations, and large-scale protein-protein interactions. Integrating gene differential expression and crosstalk effects ...


Radiance2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan Oct 2022

Radiance2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan

Medical Research Day

We aimed to identify actionable delays in care that for women with endometrial cancer (EC) from the time of gynecologic oncology (GON) referral through adjuvant therapy. A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic, treatment, and survival data were collected. Time frames between key events were calculated. Timed events were censored if there was insufficient data to make a calculation. Categorical covariates were summarized with counts and percentages; continuous variables were summarized via means and standard deviations. Categorical covariates were compared across groups using a ...


Predictors Of Equitable Receipt Of Next Generation Sequencing In Endometrial Cancerpatients Receiving Cancer Care In The Deep South, Amber R. Bardarson, Madison A. Keller, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Navya Nair, Andrew Chapple, Tara Castellano Oct 2022

Predictors Of Equitable Receipt Of Next Generation Sequencing In Endometrial Cancerpatients Receiving Cancer Care In The Deep South, Amber R. Bardarson, Madison A. Keller, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Navya Nair, Andrew Chapple, Tara Castellano

Medical Research Day

Socioeconomic status remains a predictor of endometrial cancer prognosis and is correlated with advanced disease in patients. Next Generation Sequencing (NGS) provides the ability to prescribe targeted cancer therapies and increases patient survival. Race, ethnicity, and insurance status impact the use of NGS analysis, though the degree of impact remains unclear. An IRB-Approved retrospective research study was performed using data collected of gynecologic cancer patients in a southern healthcare system through use of the electronic medical record (EMR). Baseline clinicopathologic and demographic factors were collected for all endometrial cancer patients. These factors were then tested for significant association on whether ...


Nk Cells In Uterine Cancers, Schumann Chang, Vijay Kumar, Caitlin Bauer, John Stewart Oct 2022

Nk Cells In Uterine Cancers, Schumann Chang, Vijay Kumar, Caitlin Bauer, John Stewart

Medical Research Day

Uterine cancer, which includes endometrial cancer (EC) and cervical cancer (CC), is one of the most prevalent gynecologic malignancies amongst women. It is the fourth most common cancer for women in the United States, with more than 90% of uterine cancers occurring in the endometrium. The uterus is a mucosal immune organ that supports embryonic and fetal development. However, its immune microenvironment is continuously altered depending on female sex hormones status, which varies with menstrual cycle and pregnancy. While pregnancy is considered a controlled stage of inflammation, this is not the case in carcinogenesis. This review paper focuses on NK ...


Describing The Prevalence And Unique Demographic And Clinicopathologic Features Of Hpv-Negative Cervical Cancer, Caitlyn C. Gallaspy, Joshua R. Ricks, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia M. Jernigan Oct 2022

Describing The Prevalence And Unique Demographic And Clinicopathologic Features Of Hpv-Negative Cervical Cancer, Caitlyn C. Gallaspy, Joshua R. Ricks, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia M. Jernigan

Medical Research Day

HPV-negative cervical cancer (HPV-CC) has been described to represent 10% of cervical cancer cases and to be associated with more advanced presentation and attenuated survival outcomes. The objective of this study was to describe the prevalence of HPV-CC in our region and to compare demographics and clinicopathologic features of HPV-CC to HPV-positive cervical cancer (HPV+CC). A retrospective chart review of patients diagnosed with cervical cancer at a safety-net hospital between January 1, 2015 and December 31, 2020 was conducted. HPV status was determined by HPV testing within 6 months of histologic diagnosis. HPV-CC was defined as a negative HPV ...


Estrogen, Obesity, And Anticoagulant Protein S Contribute To Thrombosis In Mice, Alaina Guilbeau, Manoj Kumar, Laurent Mosnier, Rinku Majumder Oct 2022

Estrogen, Obesity, And Anticoagulant Protein S Contribute To Thrombosis In Mice, Alaina Guilbeau, Manoj Kumar, Laurent Mosnier, Rinku Majumder

Medical Research Day

Protein S (PS) is an anticoagulant molecule present in humans and mice. Protein S binds and inhibits coagulation Factor IXa to control thrombin generation1 . Protein S is imperative for normal hemostasis and the prevention of life-threatening thrombotic events, as demonstrated by numerous studies of patients with PS deficiency2,3,4. Pregnant women5 and women who use estrogen-containing birth control pills 6 have lower levels of PS. Thus, it is postulated that estrogen downregulates PS expression in human. Because estrogen is synthesized by aromatase, which is highly expressed in adipose tissue7 , we expected that PS will be downregulated in obese mice ...


Does Mismatch Repair Deficiency Have Similar Prognostic Value For Black Endometrial Cancer Patients Compared To Non-Black Counterparts From The Deep South?, Madison A. Keller, Amber R. Bardarson, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Andrew G. Chapple, Navya Nair, Tara Castellano Oct 2022

Does Mismatch Repair Deficiency Have Similar Prognostic Value For Black Endometrial Cancer Patients Compared To Non-Black Counterparts From The Deep South?, Madison A. Keller, Amber R. Bardarson, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Andrew G. Chapple, Navya Nair, Tara Castellano

Medical Research Day

Introduction:  Endometrial cancer (EC) disproportionately affects Black women, but we do not yet know if mismatch repair deficiency (MMRd) has an equal prognostic value in the Black EC population as their White counterparts, due to poor representation of Black patients in scientific studies. We sought to describe the impact of MMRd in a large and racially diverse Southern EC population.  Methods: A retrospective cohort study of all EC patients with reported MMR testing receiving care within a large urban healthcare system of both academic and community hospitals was performed from 2018-2022. Chart review was conducted to extract patient demographic, clinicopathologic ...


Investigating The Role Of Her3 In The Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer, Margaret Larsen, Hui Lyu, Bolin Liu Oct 2022

Investigating The Role Of Her3 In The Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer, Margaret Larsen, Hui Lyu, Bolin Liu

Medical Research Day

The majority (80%) of lung cancer patients suffer from non-small cell lung cancer (NSCLC), which has a 5-year survival rate of about 19%. Prior research has shown the importance of studying epidermal growth factor receptor (EGFR) activating mutations to better understand NSCLC. These studies have led to the development of tyrosine kinase inhibitors (TKIs) that target the EGFR mutations to combat tumor growth and metastases. First and secondgeneration EGFR-TKIs are effective in NSCLC patients with the most common EGFR mutations (exon 19 deletion (Del19) and exon 21-point mutation (L858R)); however, resistance in the form of a T790M point mutation has ...


Evaluating Social Vulnerability Impact On Care & Prognosis Of Head & Neck-Nervous System Cancers In The Us, Salim C. Lutfallah, David J. Fel-Zhang, Daniel C. Chelius, Jill N. D'Souza, Jeffery C. Rastatter, Anthony M. Sheyn Oct 2022

Evaluating Social Vulnerability Impact On Care & Prognosis Of Head & Neck-Nervous System Cancers In The Us, Salim C. Lutfallah, David J. Fel-Zhang, Daniel C. Chelius, Jill N. D'Souza, Jeffery C. Rastatter, Anthony M. Sheyn

Medical Research Day

Introduction In the current literature, the association between social determinants of health (SDH) and head & neck-nervous system cancer (HNNsC) is limited by the narrow scope of SDH assessed and the broad classifications of HNNsC. Our study utilizes the CDC-Social Vulnerability Index (SVI) to assess both the individual and collective impact of four social determinant themes on various HNNsC in US adults. Methods This retrospective cohort study utilized the SEER database to evaluate 116,373 adult patients from 1975-2017 who presented with various types of HNNsC. Patients were assigned SVI scores based on county-of-residence at the time of diagnosis, encompassing total ...


Radiance1: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Rebecca Maitski, Jessica Anderson, Hannah Sibley, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan Oct 2022

Radiance1: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Rebecca Maitski, Jessica Anderson, Hannah Sibley, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan

Medical Research Day

Objective: In this cohort of women seeking care at a university practice in the Gulf South, we aimed to identify specific delays from patient experience of abnormal uterine bleeding (AUB) to referral to gynecologic oncology (GON) with a diagnosis of endometrial cancer (EC). Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic and treatment data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to ...


Radiance 2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan Oct 2022

Radiance 2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan

Medical Research Day

Objective: We aimed to identify actionable delays in care that for women with endometrial cancer (EC) from the time of gynecologic oncology referral through adjuvant therapy. Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic, treatment, and survival data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to make a calculation. Categorical covariates were summarized with counts and percentages; continuous variables were summarized via ...


Radiance: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Hannah Sibley, Jessica Anderson, Rebecca Maitski, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan Oct 2022

Radiance: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Hannah Sibley, Jessica Anderson, Rebecca Maitski, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan

Medical Research Day

Objective: In this cohort of women seeking care at a university practice in the Gulf South, we aimed to identify specific delays from patient experience of abnormal uterine bleeding (AUB) to referral to gynecologic oncology (GON) with a diagnosis of endometrial cancer (EC). Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic and treatment data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to ...


Role Of Stem Cell Transplant In Cd30+ Ptcl Following Frontline Brentuximab Vedotin Plus Chp Or Chop In Echelon-2., Kerry J Savage, Steven M Horwitz, Ranjana Advani, Jacob Haaber Christensen, Eva Domingo-Domenech, Giuseppe Rossi, Franck Morschhauser, Onder Alpdogan, Cheolwon Suh, Kensei Tobinai, Andrei Shustov, Marek Trneny, Sam Yuen, Pier Luigi Zinzani, Lorenz Trümper, Tim Ilidge, Owen A O'Connor, Barbara Pro, Harry Miao, Veronica Bunn, Keenan Fenton, Michelle Fanale, Markus Puhlmann, Swaminathan Iyer Oct 2022

Role Of Stem Cell Transplant In Cd30+ Ptcl Following Frontline Brentuximab Vedotin Plus Chp Or Chop In Echelon-2., Kerry J Savage, Steven M Horwitz, Ranjana Advani, Jacob Haaber Christensen, Eva Domingo-Domenech, Giuseppe Rossi, Franck Morschhauser, Onder Alpdogan, Cheolwon Suh, Kensei Tobinai, Andrei Shustov, Marek Trneny, Sam Yuen, Pier Luigi Zinzani, Lorenz Trümper, Tim Ilidge, Owen A O'Connor, Barbara Pro, Harry Miao, Veronica Bunn, Keenan Fenton, Michelle Fanale, Markus Puhlmann, Swaminathan Iyer

Department of Medical Oncology Faculty Papers

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas, the majority of which have high relapse rates following standard therapy. Despite use of consolidative stem cell transplant (SCT) following frontline therapy, there remains no consensus on its utility. The double-blind randomized phase 3 ECHELON-2 study (#NCT01777152; clinicaltrials.gov) demonstrated improved progression-free survival (PFS) and overall survival with frontline brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP). Herein, we conducted an exploratory subgroups analysis of the impact of consolidative SCT on PFS in patients with previously untreated CD30+ PTCL (ALK- anaplastic large cell lymphoma [ALCL] and non-ALCL ...


Lysine Methyltransferase Nsd1 And Cancers: Any Role In Melanoma?, Imène Krossa, Thomas Strub, Andrew E Aplin, Robert Ballotti, Corine Bertolotto Oct 2022

Lysine Methyltransferase Nsd1 And Cancers: Any Role In Melanoma?, Imène Krossa, Thomas Strub, Andrew E Aplin, Robert Ballotti, Corine Bertolotto

Department of Cancer Biology Faculty Papers

Epigenetic regulations, that comprise histone modifications and DNA methylation, are essential to processes as diverse as development and cancer. Among the histone post-translational modifications, lysine methylation represents one of the most important dynamic marks. Here, we focused on methyltransferases of the nuclear binding SET domain 1 (NSD) family, that catalyze the mono- and di-methylation of histone H3 lysine 36. We review the loss of function mutations of NSD1 in humans that are the main cause of SOTOS syndrome, a disease associated with an increased risk of developing cancer. We then report the role of NSD1 in triggering tumor suppressive or ...