Medicine and Health Sciences Commons^™

Aapt Diagnostic Criteria For Chronic Sickle Cell Disease Pain, Carlton Dampier, Tonya M. Palermo, Deepika S. Darbari, Kathryn Hassell, Wally Smith, William Zempsky

Neurology Publications

Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high health care costs. Although episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain experience of many older adolescents and adults. A common set of criteria for classifying chronic pain associated with SCD would enhance SCD pain research efforts in epidemiology, pain mechanisms, and clinical trials of pain management interventions, and ultimately improve clinical assessment and management. As part of the collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities …

Exploring The Lived Experiences Of Daughters/ Daughters-In-Law Providing Primary Informal Care To Their Mothers/ Mothers-In-Law With Dementia, Sarah Macfarlane

Theses and Dissertations (Comprehensive)

Abstract

Objective

As the senior population in Canada rises, more middle aged residents of Canada will find themselves taking on a caregiving role, often times for a parent with dementia. This research examines the lived experiences of daughters/daughters-in-law providing primary informal care to their mothers/mothers-in-law with dementia in order to understand the motivations, effects, and transitions within caregiving relationships.

Methods

Phenomenology was the theoretical orientation used to guide this research and captured individuals’ lived experiences. Background questionnaires were administered initially, followed by one-on-one semi-structured interviews which were transcribed verbatim upon completion for data analysis. Field notes, member checks, and triangulation …

Editorial Current Treatments For Skin Cancer, Edward Yu, Patricia Tai

Data and Test Instruments

Skin cancer is a common cancer affecting a large population of Caucasians around the world. The best treatmentresult can only be achieved by a multidisciplinary team to evaluate all host, tumor and treatment factors carefully ina particular case scenario.The thematic issue includes overviews of non-melanoma skin cancers, melanoma and Merkel cell carcinoma.The pattern of care review reflects how skin cancer is cared for in North America, such as Canada and in Europe,such as France. The paper on treatment decisions illustrates how to approach a case and make decision for treatment.The review on the role of different specialties in the team …

Characterization Of Hiv Diversity, Phylodynamics And Drug Resistance In Washington, Dc., Marcos Pérez-Losada, Amanda D Castel, Brittany Lewis, Michael Kharfen, Charles P Cartwright, Bruce Huang, Taylor Maxwell, Alan E Greenberg, Keith A Crandall

Epidemiology Faculty Publications

No abstract provided.

Fungsi Ginjal Dan Kematian Akibat Sindrom Koroner Akut, Eka Ginanjar

Jurnal Penyakit Dalam Indonesia

Penyakit kardiovaskuler merupakan salah satu penyebab kematian utama di dunia. World Health Organization (WHO) melaporkan 17,5 juta orang meninggal akibat penyakit kardiovaskuler pada tahun 2012, atau diperkirakan 3 dari 10 kematian terjadi akibat penyakit jantung.

Integrative Genomic And Transcriptomic Analysis For Pinpointing Recurrent Alterations Of Plant Homeodomain Genes And Their Clinical Significance In Breast Cancer, Huimei Yu, Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Xiaofang Chu, Zhe Yang, Zeng-Quan Yang

Oncology Faculty Publications

A wide range of the epigenetic effectors that regulate chromatin modification, gene expression, genomic stability, and DNA repair contain structurally conserved domains called plant homeodomain (PHD) fingers. Alternations of several PHD finger-containing proteins (PHFs) due to genomic amplification, mutations, deletions, and translocations have been linked directly to various types of cancer. However, little is known about the genomic landscape and the clinical significance of PHFs in breast cancer. Hence, we performed a large-scale genomic and transcriptomic analysis of 98 PHF genes in breast cancer using TCGA and METABRIC datasets and correlated the recurrent alterations with clinicopathological features and survival of …

The Efficacy Of High Intensity Interval Training On Cancer Survivors: A Systematic Reviewarticle, Yuping Huang, Weihwa Liaw, Kueiyu Chien, Chienming Chen

Rehabilitation Practice and Science

Recent studies have begun to replace low-intensity exercise with high-intensity interval training (HIIT) to improve physical fitness and health-related quality of life of cancer survivors. To the best of our knowledge, there is no systematic reviewarticle to investigate the effect of HIIT on cancer survivors. Therefore, the aim of this systematic reviewarticle study is to summarize relevant randomized controlled trials on the physiologic efficacy of HIIT on cancer survivors, and to establish the clinical intervention principles of HIIT for cancer survivors. The literature reviewarticle covered online electronic databases (Pubmed, Medline, PEDro, and CEPS) from 2000 to 2016, and searched for …

Occupational Skin Cancer And Precancerous Lesions, Fifinela Raissa, Githa Rahmayunita, Sri Linuwih Menaldi, Dewi Soemarko

Journal of General - Procedural Dermatology and Venereology Indonesia

Occupational skin cancer and precancerous lesions are skin disorders caused by exposure to chemical carcinogens such as polycyclic hydrocarbons and arsenic, or radiation, such as ultraviolet light and ionizing light in the workplace. Annual increase in skin cancer incidence is believed to be related to various factors such as frequent intense sunlight exposure (i.e. at work, recreational activities, and sun-tanning habit), ozone depletion, an increase in number of geriatric population, and an increase of public awareness in skin cancer. The most common occupational skin cancers are basal cell carcinoma, squamous cell carcinoma, and melanoma. Examples of occupational precancerous lesion of …

Vaginal Microbiota In Menopause, Martinus Martinus, Larisa Paramitha Wibawa, Evita Halim Effendi, Shannaz Nadia Yusharyahya, Hanny Nilasari, Wresti Indriatmi

Journal of General - Procedural Dermatology and Venereology Indonesia

The human vagina together with its resident, microbiota, comprise a dynamic ecosystem. Normal microbiota is dominated by Lactobacillus species, and pathogen microbiota such as Gardnerella species and Bacteroides species can occur due to decrease in Lactobacillus domination. Lactobacillus plays an essential role in keeping normal vaginal microbiota in balance. Vaginal microbiota adapts to pH change and hormonal value. Changes in the vaginal microbiota over a woman’s lifespan will influence the colonization of pathogenic microbes. They include changes in child, puberty, reproductive state, menopause, and postmenopause. Estrogen levels change will affect the colonization of pathogenic microbium, leading to genitourinary syndrome of …

Papuloerythroderma Of Ofuji: A First Case Report From Indonesia, Graciella Regina, Listya Paramita, Sunard Radiono, Yohanes Widodo Wirohadidjojo, William R. Faber

Journal of General - Procedural Dermatology and Venereology Indonesia

Papuloerythroderma (PE) is a rare skin disease which was first described by Ofuji et al. in 1984, with a typical sign that the lesions spare the large cutaneous folds, known as the deck chair sign. Due to its recent identification, this disease is still underrecognized and may lead to misdiagnosis. We reported the first case report of PE of Ofuji from Indonesia in which the diagnosis was delayed for two years. Besides the deck chair sign in the large cutaneous fold, we also found that the area between and above his eyebrows that was relatively spared in contrast to the …

Suspected Resistance Of Mdt-Mb In Multibacillary Leprosy Of Hansen's Disease: Two Case Reports, Yudo Irawan, Sri Linuwih Menaldi, Emmy Soedarmi Sd, Melani Marissa, Erika Zoulba

Journal of General - Procedural Dermatology and Venereology Indonesia

Resistance to multidrug therapy (MDT) is one of the complications in the treatment of Hansen’s disease/Morbus Hansen (MH). There are two types of resistancy, which are primary and secondary. MDT-multibacillary (MB) resistance must be suspected when no clinical improvement and the acid-fast bacilli (AFB) index is not reduced after 12 months of therapy. A 28-year-old woman with paresthesia on her face, arms and legs since 2.5 years ago, accompanied by thickening of the right posterior tibial nerve. The AFB examination showed a bacteriological index (BI) of 15/6 and morphological index (MI) of 0.50%. The second case, a 42-year-old man came …

Neural Leprosy: A Case Report, Alida Widiawaty, Emmy Soedarmi Sjamsoe-Daili, Taruli Olivia, Sri Linuwih Menaldi, Melani Marissa, Fitri Octaviana

Journal of General - Procedural Dermatology and Venereology Indonesia

Neural leprosy is characterized by neurological deficit without skin lesions, with a prevalence ranging from 1% to 17.7%. Diagnosis might be difficult and need a multidisciplinary approach. This is a case of axonal type motor and sensory polyradiculoneuropathy of the peripheral facial nerve. A 26-year-old woman was referred from the neurology clinic with facial paralysis, suspected as leprosy. Physical examinations were as follows: no skin lesions, left eye lagophthalmos, thickening of right lateral peroneal and bilateral posterior tibial nerves, sensory impairment, peripheral bilateral facial palsy, and wasting of bilateral distal small muscles of the hands, with normal autonomic function. Nerve …

Pulsed-Dye Laser Efficacy In The Treatment Of Psoriasis In Adult Patients: An Evidence-Based Case Report, Made Ananda Krisna, Hanny Nilasari

Journal of General - Procedural Dermatology and Venereology Indonesia

Psoriasis is a chronic inflammatory skin disease known to be highly responsive to phototherapy. Narrow-band UVB (NBUVB) phototherapy has been one of the standard treatments for its moderate to severe form. However, its lack of efficacy in treating stable psoriatic plaques on extremities has lead researchers to find alternative treatments, one of which is pulsed-dye laser (PDL). Laser has been known to be effective in treating vascular lesions; in psoriasis, elongation of rete ridge along with tortuous dermal capillaries are one of the first pathologies identified early in the disease progression. Several in vivo and preliminary studies have found the …

Quintavalle: The Quandary In Bioethics, Lisa Cherkassky

Journal of Law and Health

The case of R. (Quintavalle) v. Human Fertilisation Embryology Authority (and Secretary of State for Health) presents a handful of legal problems. The biggest legal query to arise from the case is the inevitable harvest of babies, toddlers and very young children for their bone marrow. This article unpacks the judicial story behind Quintavalle to reveal how the strict provisions of the Human Fertilisation and Embryology Act 1990 - namely ‘suitable condition’ under schedule 2 paragraph 1(1)(a) and ‘treatment services’ and ‘assisting’ under section 2(1) - were widely misinterpreted to introduce the social selection of embryos into law. The legal …

Streptococcus Pneumoniae Intracranial Abscess And Post-Infectious Vasculitis, Alexandra Lucas, Ko Ko Maung, Ryan Ratts

Dartmouth Scholarship

Intracranial abscesses are rare complications of Streptococcus pneumoniae infections, and to our knowledge, there have been no case reports of post-infectious vasculitis developing in such patients. Here we describe the case of a 48-year-old post-splenectomy male who developed post-infectious vasculitis following S. pneumoniae otitis media complicated by mastoiditis, osteomyelitis, meningitis, and intracranial abscess. Clinicians ought to be aware of the possible adverse outcomes of invasive S. pneumoniae and the limitations of current treatment options.

Healer, Witness, Or Double Agent? Reexamining The Ethics Of Forensic Psychiatry, Matthew U. Scherer

Journal of Law and Health

In recent years, psychiatrists have become ever more prevalent in American courtrooms. Consequently, the issue of when the usual rules of medical ethics should apply to forensic psychiatric encounters has taken on increased importance and is a continuing topic of discussion among both legal and medical scholars. A number of approaches to the problem of forensic psychiatric ethics have been proposed, but none adequately addresses the issues that arise when a forensic encounter develops therapeutic characteristics. This article looks to the rules governing the lawyer-client relationship as a model for a new approach to forensic psychiatric ethics. This new model …

Mending Invisible Wounds: The Efficacy And Legality Of Mdma-Assisted Psychotherapy In United States' Veterans Suffering With Post-Traumatic Stress Disorder, Jonathan Perry

Journal of Law and Health

Though Veteran Affairs has provided crucial life sustaining—and often lifesaving—treatments to returning soldiers, the substantial and ever-increasing rates of veteran suicides, drug addictions, and criminal behavior indicate a need for broader options in treatment. One of the most profound discoveries uncovered through MDMA-assisted psychotherapy research is MDMA’s facilitation of the alleviation of addictive behavior in subjects, and, as a result, an alleviation of addictions in general. Addiction is one of the key symptoms of post-traumatic stress disorder (PTSD) and drug abuse plays a large role in the other afflictions suffered by veterans, namely criminal activity and a high rate of …

Comparison Of Clinical And Electromyographic Characteristics Between Surgery-Related And Tumor-Related Unilateral Vocal Fold Paralysis, Chenglun Chen, Wanni Lin, Shuchun Huang, Alice M. K. Wong, Tuanjen Fang, Yucheng Pei

Rehabilitation Practice and Science

Background: The etiologies of unilateral vocal fold paralysis (UVFP) could be highly varied. It could be idiopathic or related to surgery, infection, radiation, and tumor. Among these causes of UVFP, surgery-related and idiopathic UVFP were the most well studied. However, the clinical characteristics of tumor-related UVFP have been discussed in only a few studies. Therefore, we evaluated the clinical and electromyographic characteristics of tumor-related UVFP and compared them with those of surgery-related UVFP. Methods: Laryngeal electromyography (LEMG) was performed in the thyroarytenoid-lateral cricoarytenoid muscle complexes and the cricothyroid muscles. The Short Form-36 quality-of-life questionnaire (SF-36) was applied to evaluate the …

Taiwan Guideline For Stroke Rehabilitation, Dersheng Han, Chiawei Lin, Lu Lu, Mingyen Hsiao, Chuehhung Wu, Hueywen Liang, Kevin Chang, Shinliang Pan, Tyngguey Wang, Cheinwei Chang

Rehabilitation Practice and Science

Post-stroke rehabilitation is beneficial in treatment of the impairment, disability recovery, secondary prevention, and quality-of-life enhancement. However, up-to-date treatment guidelines are still not available in Taiwan. This article reviewarticles the evidence on post-stroke rehabilitation, on which treatment guidelines in Taiwan can be based.

Comparing The Application Of Assessment Tests On Patients With Cerebrovascular Accident: The Mini-Mental Status Examination-Chinese Test Versus The Luria-Nebraska Neuropsychological Battery-Screening Test, Tingchia Wang, Yuhsin Wu, Naiwen Guo, Maohsiung Huang, Jyonghuei Su

Rehabilitation Practice and Science

Purposes: Patients with stroke often experience neurocognitive impairment; thus, an effective screening test should be developed. The Mini-Mental Status Examination-Chinese (MMSE-C) test and the Luria-Nebraska Neuropsychological Battery-Screening (LNNB-S) test are two commonly used tests for assessing cognitive impairment. In Taiwan, few studies have been conducted on the applicability of cognitive assessment tests. In the present study, we examined the assessment effectiveness of the MMSE-C and LNNB-S and compared them regarding their assessment effectiveness for impairment in various brain regions. Methods: This study was a retrospective study. Medical records from the 2005-2014 period for patients with stroke at the rehabilitation division …

Development Of A Clinical Guideline For Preventing Lower Limb Lymphedema In Patients With Gynecologic Cancer, Shinchan Lee, Chengfeng Lin, Keng Fu Hsu, Yuyun Hsu

Rehabilitation Practice and Science

Background: Women receiving gynecological cancer surgery with lymph node dissection may experience lower limb lymphedema, resulting in physical discomfort and poor quality of life (QOL). Purpose: This study developed and assessed the effectiveness of a clinical guideline for preventing lower limb lymphedema in women with gynecological cancer following surgery. Methods: The guideline was created through the following processes: defining the topic and generating clinical questions by using the PICO process, conducting a systematic literature reviewarticle and evidence appraisal, drafting the clinical guideline for Preventing Lower Limb Lymphedema in Patients with Gynecological Cancer (CGP-3L-in-GC), performing two rounds of Delphi consensus, and …

An Empirical Study Of The Relationship Among Physician-Patient Relationship Quality, Satisfaction And Loyalty Base On Experiential Marketing Perspective- Department Of Rehabilitation, Yuli Lan, Yuhua Yan, Yiching Lin, Yuping Tang, Chingming Ting

Rehabilitation Practice and Science

Objective: The purpose of the study was to use experiential marketing to explore the relationship among physician-patient relationship quality, satisfaction, and loyalty in a department of rehabilitation. Methods: A cross-sectional study was conducted. The study subjects were patients of rehabilitation department recruited from a regional hospital in Northern Taiwan using a convenient sampling strategy. A structured questionnaire was applied for data collection; the valid response rate of 190 distributed questionnaires was 96.31%. The statistical analysis methods utilized in the present study included descriptive analysis, one-way ANOVA, Pearson correlation analysis, and regression analysis. Results: The results indicated that age and occupation …

Preliminary Studies Of The Developmental Motor Assessment Scale For Preschool Children: Development And Validation, Yihan Po, Chialing Chen, Chienju Chang, Pohsi Chen, Hsiehching Chen, Chiaying Chung, Chiachi Wang, Renhuei Fu, Lituan Chou

Rehabilitation Practice and Science

Many countries have developed comprehensive developmental motor assessment scale for preschool children (DMASPC). At present, there is no comprehensive gross motor and fine motor assessment scales for preschool children in Taiwan. The purpose of this study is to develop a DMASPC specifically for Taiwanese preschool children. This study is a cross-sectional study. One hundred and seventy-seven children with typical development (91 boys and 86 girls) were enrolled and received the DMASPC test. Fifty-four of the recruited children then received a second DMASPC test within the first week after recruitment, while the other 24 children were randomly selected and received clinical …

Using Objective Ultrasonographic Findings And Subjective Self-Reported Measures To Evaluate The Effectiveness Of A Novel Single Intra-Articular Injection Of Hyaluronic Acid For The Treatment Of Knee Osteoarthritis: A Preliminary Report, Shenghui Tuan, Ihsiu Liou, Minhui Li, Yunjeng Tsai, Yinhan Chen, Tinyun Liao, Chialing Hung, Hungya Huang, Shufen Sun

Rehabilitation Practice and Science

Purpose: Osteoarthritis (OA) is the most common musculoskeletal disease worldwide. Knee OA is the most common type of OA and is the main cause of disability in elderly people. Intra-articular (IA) injection of hyaluronic acid (HA) has been widely proven to improve pain, physical function, and quality of life among patients with knee OA. However, most of the previous studies have used low-to-moderate molecular weight (MW) HA and have evaluated the clinical benefits by using subjective self-reported measures. In this study, we evaluated the efficacy of a single IA injection of a novel cross-linked HA (HYAJOINT Plus) through objective ultrasonographic …

Effects Of Virtual Reality-Based On Constraint-Induced Therapy On Upper-Extremity Function In Children With Cerebral Palsy: A Pilot Study, Yunju Lin, Chunwen Chen, Chiaying Chung, Hsiehching Chen, Chishiun Wu, Tzuling Chang, Chialing Chen

Rehabilitation Practice and Science

Children with unilateral spastic cerebral palsy (CP) often use their sound limb to perform daily activities, which results in the learned non-use of the affected limb. Recently, many clinical researches have demonstrated the effectiveness of modified constraint-induced movement therapy (mCIMT). With the development of technology, virtual reality (VR) has gradually become one of auxiliary tools in novel rehabilitation therapy. However, mCIMT often causes frustrations in using the affected upper limb. This study uses VR as auxiliary rehabilitation equipment to form a new treatment approach-virtual reality-based constraint-induced movement therapy (VRCIT)-to investigate the effects VRCIT has on the function of the upper …

Recording Somatosensory Evoked Potential Of The Posterior Tibial Nerve With A Subdural Strip During Surgery For Spinal Dysraphism And Tethered Cord Syndrome, Han-Lin Wu, Muh-Lii Liang, Hsin-Hung Chen, Chen-Liang Chou, Tsui-Fen Yang

Rehabilitation Practice and Science

Objective: To investigate the feasibility of a subdural strip, placed just proximal to the surgical field, to record somatosensory evoked potentials (SSEPs) of the posterior tibial nerve (PTN) during detethering surgery for spinal dysraphism and/or tethered cord syndrome (TCS). Method: Twenty three patients (thirteen boys and ten girls; age, 4 months to 15 years) were enrolled in this study. Eleven patients had lipomyelomeningoceles, seven had TCS, two had split cord malformations, one with terminal myelocystocele, one with VACTERL syndrome, and one had a spinal tumor at the T11 to L4 level. Aside from the routine preparation needed for functional mapping …

Cervical Disc Herniation With Myelopathy Following Cervical Tuina Manipulation, Valeria Jia-Yi Chiu, Shu-Yuan Chou, Yu-Ting Hsieh, Yi-Shiung Horng

Rehabilitation Practice and Science

Complications following cervical manipulation can be classified as cerebrovascular or noncerebrovascular complications. The former complications occur more frequently, and they are usually due to vertebral artery occlusion, damage or thrombus formation. The latter include spinal cord or nerve root injuries and have seldom been reported. Herniation of the cervical disc with myelopathy following manipulation is rare. However, we have encountered two patients who developed cervical disc herniation with myelopathy secondary to cervical tuina manipulation for nuchalgia at the bone setting facilities. One of the patients suffered from shooting pain during manipulation and developed tetraparesis two days later. An MRI examination …

The Use Of Ultrasonography To Assess Outcomes And Prognostic Indicators In Carpal Tunnel Syndrome: A Study In Patients Treated With Night Splinting, Lin-Yi Wang, Mei-Yun Liaw, Yu-Chi Huang, Hsiao-Lan Chen, Yiu-Chung Lau, Ya-Ping Pong

Rehabilitation Practice and Science

Background: Controversy exists regarding the use of ultrasonography (US) to assess outcome variables and prognostic indicators of carpal tunnel syndrome (CTS). Objective: To investigate the value of US in evaluating outcomes and prognosis for CTS treated with night splinting. Methods: Fifty-eight hands with mild to moderate CTS were prospectively enrolled; 42 diseased hands completed the study. Satisfaction rating, symptom severity score (SSS), functional status score (FSS), nerve conduction study (NCS) data, and US data were evaluated as outcome variables before and after 3 and 6 months of night splinting. On an intent-to-treat basis, a binary logistic regression analysis was used …

The Performance And Occupational Therapy Intervention Effect Of Visual-Motor Integration In Adults With Prader-Willi Syndrome: A Pilot Study, Wanling Hsu, Weihsiu Chang, Meichun Lin, Kueiyu Chou, Jangting Wei, Valeria Chiu

Rehabilitation Practice and Science

Objective. This study was attempted to investigate the performance and the effect of occupational therapy intervention via visual-motor integration (VMI), visual perception and motor coordination in adults with Prader-Willi Syndrome (PWS). Methods. seven adults with PWS were included in the study. VMI, visual perception and motor coordination were assessed using the Beery Visual-Motor Integration test and VMI Supplemental tests in the beginning of the study, shortly after receiving the treatment and one month after the intervention. Treatment was scheduled for 2 hour per week for 2 months. Results. Every adult with PWS received a low age equivalent score in VMI, …

The Effect Of Wearing Compression Tights On Cardiopulmonary Function And Running Economy In Sedentary Overweight Or Obese Females, Shuming Yeh, Huangyuan Chang, Kuosheng Yang, Guanyu Lin, Souncheng Wang, Yunju Chen

Rehabilitation Practice and Science

Purpose: Previous studies conducted on pressure garments have suggested that compression garments may have positive effects on cardiopulmonary function while performing exercises by improving peripheral venous return and reducing muscle oscillation that may cause energy loss. However, most studies have not been able to prove this hypothesis and concluded that compression has no positive effect on cardiopulmonary function while performing exercises. This study was aimed at determining whether compression garments with a pressure gradient can reduce energy loss caused by muscle oscillation and subsequently promote running economy and cardiopulmonary function in sedentary overweight females. Methods: This study was conducted with …