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2001

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Articles 1 - 30 of 1578

Full-Text Articles in Medicine and Health Sciences

Will Theaters Receive Two Thumbs Up From Individuals With Disabilities?, Joseph H. Huber Dec 2001

Will Theaters Receive Two Thumbs Up From Individuals With Disabilities?, Joseph H. Huber

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

No abstract provided.


Systems Analysis Projects In Advanced Nursing Practice Education, Barfield John, Debra Smith, Maribeth Smith Dec 2001

Systems Analysis Projects In Advanced Nursing Practice Education, Barfield John, Debra Smith, Maribeth Smith

The Corinthian

The purpose of the presentation is to stimulate discussion among nursing educators regarding integration of an educational strategy which can enhance the ability of graduate students to analyze clinical and administrative problems.


Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin Dec 2001

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …


What's Happening: December 19, 2001, Maine Medical Center Dec 2001

What's Happening: December 19, 2001, Maine Medical Center

What's Happening

No abstract provided.


Going Global The Fastest Way To The Top, Rick Burton Dec 2001

Going Global The Fastest Way To The Top, Rick Burton

Sport Management - All Scholarship

No abstract provided.


Effect Of Seeing Tobacco Use In Films On Trying Smoking Among Adolescents: Cross Sectional Study, James D. Sargent, Michael L. Beach, Madeline A. Dalton, Leila A. Mott, Jennifer J. Tickle, M. Bridget Ahrens, Todd F. Heatherton Dec 2001

Effect Of Seeing Tobacco Use In Films On Trying Smoking Among Adolescents: Cross Sectional Study, James D. Sargent, Michael L. Beach, Madeline A. Dalton, Leila A. Mott, Jennifer J. Tickle, M. Bridget Ahrens, Todd F. Heatherton

Dartmouth Scholarship

Objective: To test the hypothesis that greater exposure to smoking in films is associated with trying smoking among adolescents.


Nipple Aspirate Cytology And Pathologic Parameters Predict Residual Cancer And Nodal Involvement After Excisional Breast Biopsy., E R Sauter, H Ehya, A Mammen, G Klein Dec 2001

Nipple Aspirate Cytology And Pathologic Parameters Predict Residual Cancer And Nodal Involvement After Excisional Breast Biopsy., E R Sauter, H Ehya, A Mammen, G Klein

Department of Surgery Faculty Papers

We previously demonstrated that abnormal nipple aspirate fluid (NAF) cytology predicted residual breast cancer (RC) and tumour size after excisional biopsy (EB), although normal NAF cytology did not exclude RC. Tumour size correlates with the risk of lymph node (LN) metastases. LN metastases provide prognostic information allowing medical and radiation oncologists to determine the need for adjuvant therapy. We hypothesized that pathologic factors known after EB, combined with NAF cytology, would predict with a high degree of accuracy the presence of RC and LN spread. NAF cytology and pathologic parameters: tumour distance from biopsy margins, multifocal and multicentric disease, sub-type …


Neonatal Pain Management: The Evaluation Of Two Methods On Educating Neonatal Nurses, Jacqueline Jupin Manzi Dec 2001

Neonatal Pain Management: The Evaluation Of Two Methods On Educating Neonatal Nurses, Jacqueline Jupin Manzi

Seton Hall University Dissertations and Theses (ETDs)

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Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky Dec 2001

Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Enhanced formation of reactive oxygen species (ROS), superoxide (O2*-), and hydrogen peroxide (H2O2) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms underlying activation of the apoptotic machinery by ROS. Exposure of permeabilized HepG2 cells to O2*- elicited rapid and massive cytochrome c release (CCR), whereas H2O2 failed to induce any release. Both O2*- and H2O2 promoted activation of the mitochondrial permeability transition pore by Ca2+, but Ca2+-dependent pore opening was not required for O2*--induced CCR. Furthermore, O2*- alone evoked CCR without damage of the inner mitochondrial membrane barrier, as mitochondrial membrane potential …


Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo Dec 2001

Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo

Faculty Publications, Department of Psychology

Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then …


A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting Dec 2001

A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting

Dartmouth Scholarship

Localization of ion channels and transporters to the correct membrane of polarized epithelia is important for vectorial ion movement. Prior studies have shown that the cytoplasmic carboxyl terminus of the cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the apical localization of this protein. Here we show that the C-terminal tail alone, or when fused to the green fluorescent protein (GFP), can localize to the apical plasma membrane, despite the absence of transmembrane domains. Co-expression of the C terminus with full-length CFTR results in redistribution of CFTR from apical to basolateral membranes, indicating that both proteins interact with the …


What's Happening: December 5, 2001, Maine Medical Center Dec 2001

What's Happening: December 5, 2001, Maine Medical Center

What's Happening

No abstract provided.


Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen Dec 2001

Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen

Faculty Publications, Department of Psychology

Presumably, anger is a common experience of parenting. Although practitioners and researchers recognize the role of anger in various parenting situations, objective and standardized measures of parental anger have been notably lacking in the field. This study examined the Parental Anger Inventory (PAI), a measure developed specifically to assess parental anger in response to child misbehavior. A diverse sample of 98 parents participated in the study, including (a) physically abusive or neglectful parents, or both, n = 44; (b) nonmaltreating clinic parents seeking assistance for child behavior problems, n = 24; and (c) nonmaltreating, non–help-seeking community parents, n = 30. …


Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton Dec 2001

Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton

Dartmouth Scholarship

We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated protein by using mass spectrometry. Most of these proteins are known spindle-associated components with essential functional roles in spindle organization. We generated antibodies against a protein identified in this collection and refer to it as astrin because of its association with astral microtubule arrays assembled in vitro. Astrin is approximately 134 kDa, and except for a large predicted coiled-coil domain in its C-terminal region it lacks any known functional motifs. Astrin associates with spindle microtubules as early as prophase where it concentrates at …


Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen Dec 2001

Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen

Theses and Dissertations

Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed a systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens and ventral midbrain) across the BXD RI panel, a highly diverse family of isogenic mouse strains before and after treatment with ethanol. Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with a …


Changing Incidence Of Oral And Maxillofacial Tumours In East Java, Indonesia, 1987-1992. Part 2: Malignant Tumours, T. I. Budhy, S. D. Soenarto, H. B. Yaacob, W.C. Ngeow Dec 2001

Changing Incidence Of Oral And Maxillofacial Tumours In East Java, Indonesia, 1987-1992. Part 2: Malignant Tumours, T. I. Budhy, S. D. Soenarto, H. B. Yaacob, W.C. Ngeow

Wei Cheong Ngeow

A total of 2193 tumours of the mouth and jaw diagnosed at the Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Airlangga, Indonesia from 1987 to 1992, inclusive, was studied. Malignant tumours constituted 45.3% of the lesions. Almost 71% of the malignant tumours were squamous cell carcinomas. The remainder were salivary gland tumours (21.5%) and sarcomas (4.5%). The male to female ratio for malignant tumours was 5.1:4.7. The incidence of malignant tumours per 100,000 population over the 6-year study period was 2.64. The yearly incidence seemed to increase except in 1990, when it dropped. The incidence of squamous cell carcinoma over the …


Access To Pediatric Services Under Medicaid Managed Care In The District Of Columbia, Karen Shaw, Sara J. Rosenbaum Dec 2001

Access To Pediatric Services Under Medicaid Managed Care In The District Of Columbia, Karen Shaw, Sara J. Rosenbaum

Health Policy and Management Faculty Publications

No abstract provided.


Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001 Dec 2001

Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001 Building a dynamic multicultural community at Jefferson, page 4 Farber institute for neurosciences will be headed by Samuel Gandy, page 7 Dean Thomas Nasca’s strategic plan, page 10 Bud Bacharach’56 receives the cornerstone award, page 18


Predictors Of Injury From Fighting Among Adolescent Males, B J. Hammig, L L. Dahlberg, Monica H. Swahn Dec 2001

Predictors Of Injury From Fighting Among Adolescent Males, B J. Hammig, L L. Dahlberg, Monica H. Swahn

Public Health Faculty Publications

Objectives: To identify violence related behaviors associated with injuries among adolescent males involved in fights.

Methods: Data from the National Longitudinal Study of Adolescent Health were used to develop weighted estimates of injury prevalence and associations between injury and violence related behaviors.

Results: Forty seven per cent injured others and 18% were themselves injured in a fight among adolescent males in the preceding 12 months. Group fighting, fighting with strangers, and weapon use were predictive of injury in this sample.

Conclusions: These findings suggest that injuries associated with fighting are a health risk among adolescent males. Certain behaviors, such as …


Mapping Of Cortical Motor Reorganization In Spinal Cord Injury, Leonid Rozhkov Dec 2001

Mapping Of Cortical Motor Reorganization In Spinal Cord Injury, Leonid Rozhkov

Theses and Dissertations (ETD)

The annual incidence of spinal cord injury (SCI), not including those who die at the scene of the accident, is approximately 10,000 new cases in the United States. SCI, in its best outcome, may partially and temporarily disconnect the spinal cord from the brain. Some neuronal pathways remain intact in most S CI individuals, whose recovery depends on the utilization of the surviving connections. There is a change in the control of voluntary movements of the extremities by the cerebral cortex of the brain following spinal cord injury.

The technology of high-resolution EEG co-registered with MRI was applied to non-invasively …


Inside Unlv, Diane Russell, Jennifer Vaughan, Richard Jensen, Mae Worthey-Flennoy Dec 2001

Inside Unlv, Diane Russell, Jennifer Vaughan, Richard Jensen, Mae Worthey-Flennoy

Inside UNLV

No abstract provided.


Meeting Medical Terminology Needs: The Ontology-Enhanced Medical Concept Mapper, Gondy Leroy, Hsinchun Chen Dec 2001

Meeting Medical Terminology Needs: The Ontology-Enhanced Medical Concept Mapper, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

This paper describes the development and testing of the Medical Concept Mapper, a tool designed to facilitate access to online medical information sources by providing users with appropriate medical search terms for their personal queries. Our system is valuable for patients whose knowledge of medical vocabularies is inadequate to find the desired information, and for medical experts who search for information outside their field of expertise. The Medical Concept Mapper maps synonyms and semantically related concepts to a user's query. The system is unique because it integrates our natural language processing tool, i.e., the Arizona (AZ) Noun Phraser, with human-created …


Effects Of Antioxidant Supplementation With Vitamin E And Selenium On Cytokine Production In Mice Infected With Trypanosoma Cruzi, Dong Chen Dec 2001

Effects Of Antioxidant Supplementation With Vitamin E And Selenium On Cytokine Production In Mice Infected With Trypanosoma Cruzi, Dong Chen

Masters Theses & Specialist Projects

Dietary supplementation with the antioxidants vitamin E and selenium (Se) has been shown to be beneficial against the intracellular parasite Trypanosoma cruzi during experimental Chagas' disease. Supplementation of mice with vitamin E and selenium at levels well above the recommended daily allowance for these two substances results in significantly decreased parasitemia levels and increased longevity. However, the mechanistic role of the antioxidants in this process is not well understood. It is known that vitamin E and selenium can reduce oxidative stress and improve host immune responses. In addition, the synthesis of many regulatory cytokines is known to be influenced by …


Bacteremia Associated With Early Childhood Caries, Eddie Chang Dec 2001

Bacteremia Associated With Early Childhood Caries, Eddie Chang

Loma Linda University Electronic Theses, Dissertations & Projects

Previous research has investigated the post-operative bacteria levels caused by a variety of clinical procedures such as anesthetic injections, standard dental procedures, endodontic treatment, periodontal surgery, root scaling, and oral surgical procedures in children. Other studies have suggested that bacteremias are often caused by oral infections. Although numerous studies have examined how oral infections lead to various medical conditions (i.e. brain abscess) none have studied the potential for preoperative bacteremia that may arise in conjunction with early childhood caries (ECC). The purpose of this study was to compare potential systemic facultative and anaerobic bacteria found in otherwise healthy children who …


Effects Of Maternal Employment And Prematurity On Child Outcomes In Single Parent Families, Joanne M. Youngblut, Dorothy Brooten, Lynn T. Singer, Theresa Standing, Haejung Lee, Willard L. Rodgers Dec 2001

Effects Of Maternal Employment And Prematurity On Child Outcomes In Single Parent Families, Joanne M. Youngblut, Dorothy Brooten, Lynn T. Singer, Theresa Standing, Haejung Lee, Willard L. Rodgers

Nicole Wertheim College of Nursing and Health Sciences

Background

Effects of maternal employment for preschool children vary based on specific characteristics of the mother’s employment, the family’s economic status, and the mother’s attitudes about employment. However, there is limited research on a growing group of children at developmental risk—those born prematurely and living in a single-parent family.

Objective

To examine the effects of maternal employment and prematurity on child cognition and behavior in single-parent families.

Methods

Sixty preterm and 61 full-term preschool children were recruited through NICU admission records and birth records. Data were collected with the Kaufmann Assessment Battery for Children, Peabody Picture Vocabulary Test, Child Behavior …


Beta-Adrenergic, Arachidonic Acid And Potassium Channel Associated-Regulation Of Human Breast Cancer Cell Lines, Yavuz Cakir Dec 2001

Beta-Adrenergic, Arachidonic Acid And Potassium Channel Associated-Regulation Of Human Breast Cancer Cell Lines, Yavuz Cakir

Doctoral Dissertations

During the late stages of breast cancer progression, breast cancer cell growth switches from steroid hormone to growth factor dependence, and it is assumed that invasive breast cancers are growth factor receptor positive and estrogen hormone resistant. The cellular arachidonic acid (AA) pathway is upregulated in a variety of cancer types, and it may play an important role in the growth regulation of breast cancer cells.

Recent evidence suggests that beta-adrenergic receptors (β-ARs) are expressed in some estrogen receptor (ER) negative breast cancers and that beta agonists not only can trigger AA release via the activation of cytosolic PLA2 or …


Expression And Characterization Of The Mhc Class Ii Transactivator In K-562 Cells, Noel Elyssa Day Dec 2001

Expression And Characterization Of The Mhc Class Ii Transactivator In K-562 Cells, Noel Elyssa Day

Doctoral Dissertations

The K-562 cell line was developed from the pleural effusion of a patient with chronic myelogenous leukemia (CML) in blast crisis and has served as an excellent model to study the properties of CML cells. The highly undifferentiated cells can be induced by a variety of chemicals to follow multiple pathways of differentiation. When K-562 cells were treated with phorbol myristate acetate (PMA), they exhibited accessory cell functions by replacing monocytes in the activation of resting Th2 lymphocytes. However, K-562 cells are negative for the expression of class II major histocompatibility complex (MHC) antigens HLA-DR, -DP, and -DQ. The focus …


Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang Dec 2001

Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]


Polycyclic Aromatic Hydrocarbon Degradation By Novel Bacteria Isolated From Burrow Sediments Of Marine Benthic Macrofauna, Wai Ki Chung Dec 2001

Polycyclic Aromatic Hydrocarbon Degradation By Novel Bacteria Isolated From Burrow Sediments Of Marine Benthic Macrofauna, Wai Ki Chung

Electronic Theses and Dissertations

Polycyclic aromatic hydrocarbons (PAH) are significant environmental pollutants and represent a severe health threat. Many cosmopolitan areas including coastal environments are heavily impacted by PAH. This research investigates the isolation of PAH-degrading bacteria from burrow sediment of marine benthic macrofauna and their potential in bioremediation. Macrofaunal burrow sediment is biogeochemically distinct from bulk sediment and has high microbial activities. Samples were collected from a local uncontaminated cove and PAH degradation potential was measured by incubating sediment slurries with exogenous PAH. Burrow sediments from two polychaetes and a mollusc showed significantly higher PAH degradation potential than the bulk sediment. The degradation …


Relationship Between Nursing Nutrition Knowledge And Attitudes And Identification Of Malnutrition In The Acute Care Setting, Susan D. Kendziorski Dec 2001

Relationship Between Nursing Nutrition Knowledge And Attitudes And Identification Of Malnutrition In The Acute Care Setting, Susan D. Kendziorski

Masters Theses

Malnutrition is widespread in healthcare and effective protocols are needed to identify those at risk. Nurses are well suited to carry out screening for malnutrition because they are in close contact with the patient and are responsible to coordinate each patient's care. In order to perform this role nurses must have nutrition knowledge and the skills to complete an accurate nutrition screen. The purpose of this study was to examine relationships between nursing nutrition knowledge, nursing attitudes towards nutrition, and the accurate completion of a nutrition screening protocol. Patient's charts were reviewed for accurate completion of the nutrition screening protocol …