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Full-Text Articles in Medicine and Health Sciences

Incidence And Mortality Of Uveal Melanoma In Australia (1982–2014), Aaron B. Beasley, David B. Preen, Samuel Mclenachan, Elin S. Gray, Fred K. Chen Jan 2023

Incidence And Mortality Of Uveal Melanoma In Australia (1982–2014), Aaron B. Beasley, David B. Preen, Samuel Mclenachan, Elin S. Gray, Fred K. Chen

Research outputs 2014 to 2021

Aims:

We aimed to estimate the incidence and mortality of uveal melanoma (UM) in Australia from 1982 to 2014.

Methods:

Deidentified unit data for all cases of ocular melanoma were extracted from the Australian Cancer Database from 1 January 1982 to 31 December 2014. UM cases were extracted and trends in incidence and disease-specific mortality were calculated. Incidence rates were age-standardised against the 2001 Australian Standard Population. Mortality was assessed using Cox regression.

Results:

From 1982 to 2014, there were 5087 cases of ocular melanoma in Australia, of which 4617 were classified as UM. The average age-standardised incidence rate of …


Burden And Preference-Based Quality Of Life Associated With Bullying In Children, Long K. D. Le, Mary L. Chatterton, Ronald M. Rapee, Sally Fitzpatrick, Kay Bussey, Jennie Hudson, Caroline Hunt, Donna Cross, Anne Magnus, Cathrine Mihalopoulos Jan 2023

Burden And Preference-Based Quality Of Life Associated With Bullying In Children, Long K. D. Le, Mary L. Chatterton, Ronald M. Rapee, Sally Fitzpatrick, Kay Bussey, Jennie Hudson, Caroline Hunt, Donna Cross, Anne Magnus, Cathrine Mihalopoulos

Research outputs 2014 to 2021

The objectives of this study are to assess the association between childhood bullying and preference-based health-related quality of life (QoL) in Australian school children and their parents and estimate quality-adjusted life years (QALYs) associated with bullying chronicity. Children aged 8–10 years completed the child health utilities (CHU-9D), while parents completed the Australian quality of life (AQoL-8D). Children were grouped into four categories of bullying involvement (no bullying, victim, perpetrator, or both perpetrator and victim) based on the Revised Olweus Bully/Victim Questionnaire. Parental data were compared across two bullying involvement groups (bullying vs. no bullying). QALYs were calculated for children over …


Treatment Integrity And Differentiation In The Very Early Rehabilitation In Speech (Verse) Trial, Emily Brogan, Natalie Ciccone, Erin Godecke Jan 2023

Treatment Integrity And Differentiation In The Very Early Rehabilitation In Speech (Verse) Trial, Emily Brogan, Natalie Ciccone, Erin Godecke

Research outputs 2014 to 2021

Background:

Key elements of treatment fidelity include treatment integrity (adherence to the treatment protocol) and treatment differentiation (the difference in treatment ingredients in the control and intervention groups). The Very Early Rehabilitation in SpEech (VERSE) trial established treatment fidelity at the macro level for key components of therapy.

Aims:

To complete a detailed analysis of treatment integrity and differentiation at the utterance level of a therapeutic interaction.

Methods:

This was an observational study of therapy videos collected as part of the VERSE trial. Participants were people with aphasia in the very early phase of recovery post stroke (n = 44) …


Abdominal Aortic Calcification, Cardiac Troponin I And Atherosclerotic Vascular Disease Mortality In Older Women, Ryan Teh, Richard L. Prince, Marc Sim, John T. Schousboe, Warren Raymond, Pawel Szulc, Wai Lim, Jonathan M. Hodgson, Kun Zhu, Douglas P. Kiel, Carl Schultz, Peter L. Thompson, Joshua Lewis Dec 2022

Abdominal Aortic Calcification, Cardiac Troponin I And Atherosclerotic Vascular Disease Mortality In Older Women, Ryan Teh, Richard L. Prince, Marc Sim, John T. Schousboe, Warren Raymond, Pawel Szulc, Wai Lim, Jonathan M. Hodgson, Kun Zhu, Douglas P. Kiel, Carl Schultz, Peter L. Thompson, Joshua Lewis

Research outputs 2014 to 2021

Objective:

Examine if two inexpensive measures of atherosclerotic vascular diseases (ASVD), abdominal aortic calcification (AAC) and high-sensitivity cardiac troponin I (hs-cTnI) provide complementary information for 10-year ASVD mortality and all-cause mortality risk in older women.

Methods:

908 community-dwelling women without prevalent ASVD ( ≥ 75 years) were followed-up between 2003 and 2013. AAC and plasma hs-cTnI measures were obtained in 2003. AAC was assessed on lateral spine images using a semiquantitative method (AAC24). Linked health records were used for mortality outcomes.

Results:

Mean±SD age was 79.9±2.6 years. 276 (30.4%) women died during follow-up, including 138 (15.2%) ASVD-related deaths. AAC24 and …


Occupational Therapists And Physiotherapists Weighing Up The Dignity Of Risk For People Living With A Brain Injury: Grounded Theory, Mandy Stanley, Gisela Van Kessel, Carolyn M. Murray, Deborah Forsythe, Shylie Mackintosh Oct 2022

Occupational Therapists And Physiotherapists Weighing Up The Dignity Of Risk For People Living With A Brain Injury: Grounded Theory, Mandy Stanley, Gisela Van Kessel, Carolyn M. Murray, Deborah Forsythe, Shylie Mackintosh

Research outputs 2014 to 2021

Purpose:

Following a brain injury survivors may have physical, or cognitive changes or behaviours which bring safety risks into play when engaging in activities. Therapists experience tensions in enabling the dignity of participation in the context of managing risk.

Materials and methods:

Ten occupational therapists and seven physiotherapists participated in a grounded theory study utilising semi-structured in-depth interviews to explore the tensions between dignity and management of safety risks. Data were analysed using constant comparative method and a process of moving from open coding to categories to theory development.

Results:

The process of weighing up was central to the therapists’ …


Countermovement Jump And Squat Jump Force-Time Curve Analysis In Control And Fatigue Conditions, Steven Hughes, John Warmenhoven, G. Gregory Haff, Dale W. Chapman, Sophia Nimphius Oct 2022

Countermovement Jump And Squat Jump Force-Time Curve Analysis In Control And Fatigue Conditions, Steven Hughes, John Warmenhoven, G. Gregory Haff, Dale W. Chapman, Sophia Nimphius

Research outputs 2014 to 2021

This study aimed to reanalyze previously published discrete force data from countermovement jumps (CMJs) and squat jumps (SJs) using statistical parametric mapping (SPM), a statistical method that enables analysis of data in its native, complete state. Statistical parametric mapping analysis of 1-dimensional (1D) force-time curves was compared with previous zero-dimensional (0D) analysis of peak force to assess sensitivity of 1D analysis. Thirty-two subjects completed CMJs and SJs at baseline, 15 minutes, 1, 24, and 48 hours following fatigue and control conditions in a pseudo random cross-over design. Absolute (CMJABS/SJABS) and time-normalized (CMJNORM/SJNORM) …


Factors Affecting Hospital Readmission Rates Following An Acute Coronary Syndrome: A Systematic Review, Amineh Rashidi, Lisa Whitehead, Courtney Glass Sep 2022

Factors Affecting Hospital Readmission Rates Following An Acute Coronary Syndrome: A Systematic Review, Amineh Rashidi, Lisa Whitehead, Courtney Glass

Research outputs 2014 to 2021

Aim

To synthesise quantitative evidence on factors that impact hospital readmission rates following ACS with comorbidities.

Design

Systematic review and narrative synthesis.

Data Sources

A search of eight electronic databases, including Embase, Medline, PsycINFO, Web of Science, CINAHL, Cochrane Library, Scopus and the Joanna Briggs Institute (JBI).

Review Methods

The search strategy included keywords and MeSH terms to identify English language studies published between 2001 and 2020. The quality of included studies was assessed by two independent reviewers, using Joanna Briggs Institute (JBI) critical appraisal tools.

Results

Twenty-four articles were included in the review. All cause 30-day readmission rate was …


Evaluation Of An Australian Neurological Nurse-Led Model Of Postdischarge Care, Judith Dianne Pugh, Kathleen Mccoy, Merrilee Needham, Leanne Jiang, Margaret Giles, Elizabeth Mckinnon, Kym Heine Jul 2022

Evaluation Of An Australian Neurological Nurse-Led Model Of Postdischarge Care, Judith Dianne Pugh, Kathleen Mccoy, Merrilee Needham, Leanne Jiang, Margaret Giles, Elizabeth Mckinnon, Kym Heine

Research outputs 2014 to 2021

Neurological disorders are a leading cause of disease burden worldwide, placing a heavy demand on health systems. This study evaluated the impacts and cost savings of a community-based nursing service providing supported discharge for neurological patients deemed high-risk for unplanned emergency department presentations and/or hospital readmissions. It focused on adult patients with stroke, epilepsy, migraine/headache or functional neurological disorders discharged from a Western Australian tertiary hospital. An observational design was used comprising prospective enrolment of patients receiving nurse-led supported discharge and follow-up (Neurocare), 21 August 2018 to 6 December 2019 (N = 81), and hospital administrative data, 1 February …


Patient Experience Surveys For Children’S Community Health Services: A Scoping Review, Helen J. Nelson, Catherine Pienaar, Anne M. Williams, Ailsa Munns, Katie Mckenzie, Evalotte Mörelius Mar 2022

Patient Experience Surveys For Children’S Community Health Services: A Scoping Review, Helen J. Nelson, Catherine Pienaar, Anne M. Williams, Ailsa Munns, Katie Mckenzie, Evalotte Mörelius

Research outputs 2014 to 2021

Patient experience surveys have a user focus and measure the quality of person-centered health care for hospital inpatients and consumers of community health services, providing a governance process to evaluate the quality of care and to action improvement. Experience of care has been described as effective communication, respect and dignity, and emotional support. Measurement criteria for these domains are not standardized, leading to inconsistent reporting of patient experience. The objective of this scoping review was to synthesize evidence for measuring experience of care in children’s community health services using the Joanna Briggs Institute framework for scoping review method. Three parent-reported …


An Intergenerational Playgroup In An Australian Residential Aged-Care Setting: A Qualitative Case Study, Gabrielle B. Rosa Hernandez, Carolyn M. Murray, Mandy Stanley Feb 2022

An Intergenerational Playgroup In An Australian Residential Aged-Care Setting: A Qualitative Case Study, Gabrielle B. Rosa Hernandez, Carolyn M. Murray, Mandy Stanley

Research outputs 2014 to 2021

Intergenerational programs are emerging within the aged-care context as they provide a unique opportunity for older adults living with or without cognitive impairments to connect with children. One type of intergenerational program is an ‘intergenerational playgroup’ which creates opportunities for children to develop their skills, parents to create a local peer support network and provides older adults at risk of isolation with vital community interaction. The objective of this research was to evaluate an intergenerational playgroup taking place weekly within a residential aged-care setting. A qualitative case study research design was used to perform five observation sessions and semi-structured in-depth …


Does Midwifery-Led Care Demonstrate Care Ethics: A Template Analysis, Kate Buchanan, Elizabeth Newnham, Deborah Ireson, Clare Davison, Sara Bayes Feb 2022

Does Midwifery-Led Care Demonstrate Care Ethics: A Template Analysis, Kate Buchanan, Elizabeth Newnham, Deborah Ireson, Clare Davison, Sara Bayes

Research outputs 2014 to 2021

Background:

Ethical care in maternity is fundamental to providing care that both prevents harm and does good, and yet, there is growing acknowledgement that disrespect and abuse routinely occur in this context, which indicates that current ethical frameworks are not adequate. Care ethics offers an alternative to the traditional biomedical ethical principles.

Research aim:

The aim of the study was to determine whether a correlation exists between midwifery-led care and care ethics as an important first step in an action research project.

Research design:

Template analysis was chosen for this part of the action research. Template analysis is a design …


Associations Of Fat And Muscle Mass With Overall Survival In Men With Prostate Cancer: A Systematic Review With Meta-Analysis, Pedro Lopez, Robert U. Newton, Dennis R. Taaffe, Favil Singh, Laurien M. Buffart, Nigel Spry, Colin Tang, Fred Saad, Daniel A. Galvao Jan 2022

Associations Of Fat And Muscle Mass With Overall Survival In Men With Prostate Cancer: A Systematic Review With Meta-Analysis, Pedro Lopez, Robert U. Newton, Dennis R. Taaffe, Favil Singh, Laurien M. Buffart, Nigel Spry, Colin Tang, Fred Saad, Daniel A. Galvao

Research outputs 2014 to 2021

Background

To systematically review and analyse the associations between fat and muscle mass measures with overall survival in men with prostate cancer.

Methods

A systematic search was conducted in CINAHL, Cochrane Library, EMBASE, PubMed, and Web of Science databases from inception to December 2020, while abstracts from the American Society of Clinical Oncology (ASCO), Clinical Oncology Society of Australia (COSA), and the American College of Sports Medicine (ACSM) conferences were searched from 2014 to 2020. Eligible articles examined the association of body composition measures, such as fat mass (e.g., fat mass, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and …


Work-Based Concerns Of Australian Frontline Healthcare Workers During The First Wave Of The Covid-19 Pandemic, Michella Hill, Erin Smith, Brennen W. Mills Jan 2022

Work-Based Concerns Of Australian Frontline Healthcare Workers During The First Wave Of The Covid-19 Pandemic, Michella Hill, Erin Smith, Brennen W. Mills

Research outputs 2014 to 2021

Objective: This research sought to gauge the extent to which doctors, nurses and paramedics in Australia were concerned about contracting SARS-CoV-2 during the country's first wave of the virus in April 2020.

Methods: Australian registered doctors, nurses and paramedics (n=580) completed an online questionnaire during April 16–30, 2020 (period immediately following the highest four-week period (first wave) of SARS-CoV-2 confirmed cases in Australia).

Results: During April 2020, two-thirds of participants felt it was likely they would contract SARS-CoV-2 at work. Half the participants suggested Personal Protective Equipment (PPE) supplies were inadequate for them to safely perform their job, with two-thirds …


Urinary Metabotype Of Severe Asthma Evidences Decreased Carnitine Metabolism Independent Of Oral Corticosteroid Treatment In The U-Biopred Study, Stacey N. Reinke, Shama Naz, Romanas Chaleckis, Hector Gallart-Ayala, Johan Kolmert, Nazanin Z. Kermani, Angelica Tiotiu, David I. Broadhurst, Anders Lundqvist, Henric Olsson, Marika Strom, Asa M. Wheelock, Cristina Gómez, Magnus Ericsson, Ana R. Sousa, John H. Riley, Stewart Bates, James Scholfield, Matthew Loza, Frederic Baribaud, Per S. Bakke, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Annelie Behndig, Florian Singer, Jacek Musial, Dominick E. Shaw, Barbro Dahlén, Sile Hu, Jessica Lasky-Su, Peter J. Sterk, Kian Fan Chung, Ratko Djukanovic, Sven Erik Dahlé, Ian M. Adcock, Craig E. Wheelock Jan 2022

Urinary Metabotype Of Severe Asthma Evidences Decreased Carnitine Metabolism Independent Of Oral Corticosteroid Treatment In The U-Biopred Study, Stacey N. Reinke, Shama Naz, Romanas Chaleckis, Hector Gallart-Ayala, Johan Kolmert, Nazanin Z. Kermani, Angelica Tiotiu, David I. Broadhurst, Anders Lundqvist, Henric Olsson, Marika Strom, Asa M. Wheelock, Cristina Gómez, Magnus Ericsson, Ana R. Sousa, John H. Riley, Stewart Bates, James Scholfield, Matthew Loza, Frederic Baribaud, Per S. Bakke, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Annelie Behndig, Florian Singer, Jacek Musial, Dominick E. Shaw, Barbro Dahlén, Sile Hu, Jessica Lasky-Su, Peter J. Sterk, Kian Fan Chung, Ratko Djukanovic, Sven Erik Dahlé, Ian M. Adcock, Craig E. Wheelock

Research outputs 2014 to 2021

Introduction: Asthma is a heterogeneous disease with poorly defined phenotypes. Severe asthmatics often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it challenging to investigate underlying disease mechanisms. Here, we aimed to identify dysregulated metabolic processes in relation to asthma severity and medication. Methods: Baseline urine was collected prospectively from healthy participants (n=100), mild-to-moderate asthmatics (n=87) and severe asthmatics (n=418) in the cross-sectional U-BIOPRED cohort; 12–18-month longitudinal samples were collected from severe asthmatics (n=305). Metabolomics data were acquired using high-resolution mass spectrometry and analysed using univariate and multivariate methods. Results: Ninety metabolites were identified, …


Inter-Rater Reliability, Intra-Rater Reliability And Internal Consistency Of The Brisbane Evidence-Based Language Test, Alexia Rohde, Molly Mccracken, Linda Worrall, Anna Farrell, Robyn O'Halloran, Erin Godecke, Michael David, Suhail A. Doi Jan 2022

Inter-Rater Reliability, Intra-Rater Reliability And Internal Consistency Of The Brisbane Evidence-Based Language Test, Alexia Rohde, Molly Mccracken, Linda Worrall, Anna Farrell, Robyn O'Halloran, Erin Godecke, Michael David, Suhail A. Doi

Research outputs 2014 to 2021

Purpose: To examine the inter-rater reliability, intra-rater reliability, internal consistency and practice effects associated with a new test, the Brisbane Evidence-Based Language Test. Methods: Reliability estimates were obtained in a repeated-measures design through analysis of clinician video ratings of stroke participants completing the Brisbane Evidence-Based Language Test. Inter-rater reliability was determined by comparing 15 independent clinicians’ scores of 15 randomly selected videos. Intra-rater reliability was determined by comparing two clinicians’ scores of 35 videos when re-scored after a two-week interval. Results: Intraclass correlation coefficient (ICC) analysis demonstrated almost perfect inter-rater reliability (0.995; 95% confidence interval: 0.990–0.998), intra-rater reliability (0.994; 95% …


Utilising A Systematic Review-Based Approach To Create A Database Of Individual Participant Data For Meta- And Network Meta-Analyses: The Release Database Of Aphasia After Stroke, Louise R. Williams, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M T Jesus, Maria Kambanaros, Eun K. Kang, Eman M. Khedr, Anthony P H Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann C. Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca S. Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel P. Martins, Cathy Price, Tatjana P. Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather H. Wright, Marian C. Brady, The Release Collaborators Jan 2022

Utilising A Systematic Review-Based Approach To Create A Database Of Individual Participant Data For Meta- And Network Meta-Analyses: The Release Database Of Aphasia After Stroke, Louise R. Williams, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M T Jesus, Maria Kambanaros, Eun K. Kang, Eman M. Khedr, Anthony P H Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann C. Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca S. Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel P. Martins, Cathy Price, Tatjana P. Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather H. Wright, Marian C. Brady, The Release Collaborators

Research outputs 2014 to 2021

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned …


Universal Child Health And Early Education Service Use From Birth Through Kindergarten And Developmental Vulnerability In The Preparatory Year (Age 5 Years) In Tasmania, Australia, Catherine L. Taylor, Daniel Christensen, Kim Jose, Stephen R. Zubrick Jan 2022

Universal Child Health And Early Education Service Use From Birth Through Kindergarten And Developmental Vulnerability In The Preparatory Year (Age 5 Years) In Tasmania, Australia, Catherine L. Taylor, Daniel Christensen, Kim Jose, Stephen R. Zubrick

Research outputs 2014 to 2021

This study investigated patterns of universal health and education service use from birth through Kindergarten (age 4 years) and estimated associations between cumulative risk and service use patterns, and between service use patterns and children's developmental vulnerability in the Preparatory Year (age 5 years). The study used population-wide linkage of health and education administrative data records for 5168 children who had a 2018 AEDC instrument collected in Tasmania and were born in Tasmania (2011–2013). Latent class analysis (LCA) identified three service use patterns: Regular (72.2 per cent of children; reference group), Low (15.6 per cent of children) and High service …


Alzheimer's Disease Research Progress In Australia: The Alzheimer's Association International Conference Satellite Symposium In Sydney, Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jürgen Götz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori Nakamura, Giulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson Jan 2022

Alzheimer's Disease Research Progress In Australia: The Alzheimer's Association International Conference Satellite Symposium In Sydney, Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jürgen Götz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori Nakamura, Giulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson

Research outputs 2014 to 2021

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms …


Protocol For The Development Of The International Population Registry For Aphasia After Stroke (I-Praise), M. Ali, A. L. Ben Basat, M. Berthier, M. B. Johansson, C. Breitenstein, D. A. Cadilhac, F. Constantinidou, M. Cruice, G. Davila, M. Gandolfi, M. Gil, R. Grima, Erin Godecke, L. Jesus, L. M. Jiminez, M. Kambanaros, T. Kukkonen, A. Laska, I. Mavis, R. Mc Menamin, C. Mendez-Orellana, H. Obrig, P. Ostberg, H. Robson, K. Sage, M. Van De Sandt-Koenderman, K. Sprecht, E. Visch-Brink, E. Wehling, S. Wielaert, S. J. Wallace, L. J. Williams, M. C. Brady Jan 2022

Protocol For The Development Of The International Population Registry For Aphasia After Stroke (I-Praise), M. Ali, A. L. Ben Basat, M. Berthier, M. B. Johansson, C. Breitenstein, D. A. Cadilhac, F. Constantinidou, M. Cruice, G. Davila, M. Gandolfi, M. Gil, R. Grima, Erin Godecke, L. Jesus, L. M. Jiminez, M. Kambanaros, T. Kukkonen, A. Laska, I. Mavis, R. Mc Menamin, C. Mendez-Orellana, H. Obrig, P. Ostberg, H. Robson, K. Sage, M. Van De Sandt-Koenderman, K. Sprecht, E. Visch-Brink, E. Wehling, S. Wielaert, S. J. Wallace, L. J. Williams, M. C. Brady

Research outputs 2014 to 2021

Background: We require high-quality information on the current burden, the types of therapy and resources available, methods of delivery, care pathways and long-term outcomes for people with aphasia. Aim: To document and inform international delivery of post-stroke aphasia treatment, to optimise recovery and reintegration of people with aphasia. Methods & Procedures: Multi-centre, prospective, non-randomised, open study, employing blinded outcome assessment, where appropriate, including people with post-stroke aphasia, able to attend for 30 minutes during the initial language assessment, at first contact with a speech and language therapist for assessment of aphasia at participating sites. There is no study-mandated intervention. Assessments …


Independent And Interactive Associations Of Dietary Nitrate And Salt Intake With Blood Pressure And Cognitive Function: A Cross-Sectional Analysis In The Inchianti Study, Andrea M. Mcgrattan, Blossom C. M. Stephan, Oliver M. Shannon, Mohsen Mazidi, Mark Gilchrist, Miranda Smallwood, Paul Winyard, Nicholas Mcmahon, Lauren C. Blekkenhorst, Devi Mohan, Stefania Bandinelli, Louise Robinson, Luigi Ferrucci, Mario Siervo Jan 2022

Independent And Interactive Associations Of Dietary Nitrate And Salt Intake With Blood Pressure And Cognitive Function: A Cross-Sectional Analysis In The Inchianti Study, Andrea M. Mcgrattan, Blossom C. M. Stephan, Oliver M. Shannon, Mohsen Mazidi, Mark Gilchrist, Miranda Smallwood, Paul Winyard, Nicholas Mcmahon, Lauren C. Blekkenhorst, Devi Mohan, Stefania Bandinelli, Louise Robinson, Luigi Ferrucci, Mario Siervo

Research outputs 2014 to 2021

Blood pressure (BP) control is a key target for interventions to reduce cognitive decline. This cross-sectional study explored associations between objective (24-hour urine excretion) and subjective (food frequency questionnaire [FFQ]) measures of dietary sodium and nitrate intakes with cognitive function and resting BP in the InCHIANTI cohort. Baseline data from 989 participants aged >50 years were included. In fully adjusted models, participants with concurrent high nitrate and low sodium (Odds Ratio (OR)=0.49, 95%CI 0.32–0.76, p = 0.001) and high nitrate and high sodium (OR = 0.49, 95%CI 0.32–0.77, p = 0.002) 24-hour urinary concentrations had lower odds of high BP …


The Use Of Complementary Medicine During Childbearing Years: A Multi-Country Study Of Women From The Middle East, Diana Arabiat, Lisa Whitehead, Samia Gaballah, Nazi Nejat, Ebtehal Galal, Eman Abu Sabah, Nazek Smadi, Inas Saadeh, Randa Khlaif Jan 2022

The Use Of Complementary Medicine During Childbearing Years: A Multi-Country Study Of Women From The Middle East, Diana Arabiat, Lisa Whitehead, Samia Gaballah, Nazi Nejat, Ebtehal Galal, Eman Abu Sabah, Nazek Smadi, Inas Saadeh, Randa Khlaif

Research outputs 2014 to 2021

The prevalence of self-prescribed complementary medicine (CM) use is an area of concern across the Middle East. We conducted a descriptive qualitative study to describe women’s use of CM during their childbearing years in Egypt, Jordan, Saudi Arabia and Iran. The study conducted using face to face audio-recorded interviews with 70 participants. Our findings showed that women used several herbal plants to ease pain and discomfort during menstruation and/or during pregnancy and in postpartum care. Acupuncture, meditation, and massage were less likely to be used by women. The impact of CM was often described in relation to perceived usefulness and …


The Association Between An Energy-Adjusted Dietary Inflammatory Index And Inflammation In Rural And Urban Black South Africans, Maylene Ferreira, H. Toinét Cronjé, Tertia Van Zyl, Nicola P. Bondonno, Marlien Pieters Jan 2022

The Association Between An Energy-Adjusted Dietary Inflammatory Index And Inflammation In Rural And Urban Black South Africans, Maylene Ferreira, H. Toinét Cronjé, Tertia Van Zyl, Nicola P. Bondonno, Marlien Pieters

Research outputs 2014 to 2021

Objective:

To quantify the inflammatory potential of the diet of rural and urban Black South Africans using an adapted energy-adjusted dietary inflammatory index (AE-DII) and to investigate its relationship with inflammatory and cardio-metabolic disease risk markers. Dietary inflammatory potential has not been investigated in African populations.

Design:

Cross-sectional investigation.

Setting:

Rural and urban sites in the North West province of South Africa.

Participants:

1,885 randomly selected, apparently healthy Black South Africans older than 30 years.

Results:

AE-DII scores ranged from -3.71 to +5.08 with a mean of +0.37. AE-DII scores were significantly higher in men (0.47±1.19) than in women (0.32±1.29), …


Developing A Community Rehabilitation And Lifestyle Service For A Remote Indigenous Community, Alice Cairns, Lynore Geia, Sylvia Kris, Elizabeth Armstrong, Amy O’Hara, Danielle Rodda, Robyn Mcdermott, Ruth Barker Jan 2022

Developing A Community Rehabilitation And Lifestyle Service For A Remote Indigenous Community, Alice Cairns, Lynore Geia, Sylvia Kris, Elizabeth Armstrong, Amy O’Hara, Danielle Rodda, Robyn Mcdermott, Ruth Barker

Research outputs 2014 to 2021

Purpose

Community rehabilitation is an essential health service that is often not available to remote Australians. This paper describes the first cycle of a collaborative project, between local community members, allied health professionals and a university, to co-design a community rehabilitation and lifestyle service to support adults and older people to stay strong and age well in place.

Methods

An action research framework was used to develop the service for adults in two remote communities, one being a discrete Aboriginal community. The first cycle involved planning for, and trialling of a service, with observations, reflections and feedback from clients, community …


Detection Of Clinical Progression Through Plasma Ctdna In Metastatic Melanoma Patients: A Comparison To Radiological Progression, Gabriela Marsavela, Ashleigh C. Mcevoy, Michelle R. Pereira, Anna L. Reid, Zeyad Al-Ogaili, Lydia Warburton, Muhammad K. Khattak, Afaf Abed, Tarek M. Meniawy, Michael Millward, Melanie R. Ziman Dr, Leslie Calapre, Elin S. Gray Jan 2022

Detection Of Clinical Progression Through Plasma Ctdna In Metastatic Melanoma Patients: A Comparison To Radiological Progression, Gabriela Marsavela, Ashleigh C. Mcevoy, Michelle R. Pereira, Anna L. Reid, Zeyad Al-Ogaili, Lydia Warburton, Muhammad K. Khattak, Afaf Abed, Tarek M. Meniawy, Michael Millward, Melanie R. Ziman Dr, Leslie Calapre, Elin S. Gray

Research outputs 2014 to 2021

Background

The validity of circulating tumour DNA (ctDNA) as an indicator of disease progression compared to medical imaging in patients with metastatic melanoma requires detailed evaluation.

Methods

Here, we carried out a retrospective ctDNA analysis of 108 plasma samples collected at the time of disease progression. We also analysed a validation cohort of 66 metastatic melanoma patients monitored prospectively after response to systemic therapy.

Results

ctDNA was detected in 62% of patients at the time of disease progression. For 67 patients that responded to treatment, the mean ctDNA level at progressive disease was significantly higher than at the time of …


Why Do Parents Refuse Childhood Vaccination? Reasons Reported In Finland, Johanna Nurmi, Bronwyn Harman Jan 2022

Why Do Parents Refuse Childhood Vaccination? Reasons Reported In Finland, Johanna Nurmi, Bronwyn Harman

Research outputs 2014 to 2021

Aims: This article examines the reasons for partial and complete refusal of childhood vaccination as reported by parents in Finland. It analyzes perceptions and experiences central in vaccination decisions. Methods: The analysis is based on 38 in-depth interviews with Finnish parents who have refused all or several vaccines for their children. The interviews were analyzed using qualitative content analysis. Results: Three categories of reasons were identified in the analysis: 1) risks and effects of vaccination – concern about and/or experiences of possible side-effects was the most important reason for avoiding vaccines; 2) distrust – participants did not trust vaccination recommendations …


An Aphasia Research Agenda – A Consensus Statement From The Collaboration Of Aphasia Trialists, Myzoon Ali, Efstathia Soroli, Luis M. T. Jesus, Madeline Cruice, Jytte Isaksen, Evy Visch-Brink, Kleanthes K. Grohmann, C. Jagoe, Tarja Kukkonen, Spyridoula Varlokosta, Carlos Hernandez-Sacristan, Vicente Rosell-Clari, Rebecca Palmer, Silvia Martinez-Ferreiro, Erin Godecke, Sarah J. Wallace, Ruth Mcmenamin, David Copland, Caterina Breitenstein, Audrey Bowen, Ann-Charlotte Laska, Katerina Hilari, Marian C. Brady Jan 2022

An Aphasia Research Agenda – A Consensus Statement From The Collaboration Of Aphasia Trialists, Myzoon Ali, Efstathia Soroli, Luis M. T. Jesus, Madeline Cruice, Jytte Isaksen, Evy Visch-Brink, Kleanthes K. Grohmann, C. Jagoe, Tarja Kukkonen, Spyridoula Varlokosta, Carlos Hernandez-Sacristan, Vicente Rosell-Clari, Rebecca Palmer, Silvia Martinez-Ferreiro, Erin Godecke, Sarah J. Wallace, Ruth Mcmenamin, David Copland, Caterina Breitenstein, Audrey Bowen, Ann-Charlotte Laska, Katerina Hilari, Marian C. Brady

Research outputs 2014 to 2021

Coordination of international aphasia research would minimise duplication of effort, support synergistic international activities across languages and multidisciplinary perspectives, and promote high-quality conduct and reporting of aphasia research, thereby increasing the relevance, transparency, and implementation of findings. The Collaboration of Aphasia Trialists (CATs) sought to develop an aphasia research agenda to direct future research activities, based on priorities shared by people with aphasia, family members, and healthcare professionals. Our established international research network spanning 33 countries contributed to this activity. Research literature reporting the priorities of stakeholders was reviewed and synthesized (phase 1). Representatives from Working Groups on Aphasia Assessment …


Fatality Risk Management: Applying Quinlan’S Ten Pathways In Western Australia’S Mining Industry, Tanya Jenke, Jessica L. Boylan, Shelley Beatty, Martin Ralph, Andrew Chaplyn, Greg Penney, Marcus Cattani Jan 2022

Fatality Risk Management: Applying Quinlan’S Ten Pathways In Western Australia’S Mining Industry, Tanya Jenke, Jessica L. Boylan, Shelley Beatty, Martin Ralph, Andrew Chaplyn, Greg Penney, Marcus Cattani

Research outputs 2014 to 2021

In ‘Ten Pathways to Death and Disaster’ Professor Michael Quinlan (2014) identified a series of ten common catastrophic incident risk factors, known as the Ten Pathways, contributing to major incidents in mining and other high hazard industries. This study applies the Quinlan methodology in two separate phases. The first phase of the study explored employee perception of employer effectiveness of fatality prevention against each of the Ten Pathways through a questionnaire of n = 2009 participants at the 2017–2019 Western Australian Government Mines Safety Roadshows. Respondents generally perceived their employer as having a relatively good understanding of the role of …


Digging For Data: How Sleep Is Losing Out To Roster Design, Sleep Disorders, And Lifestyle Factors, Gemma Maisey, Marcus Cattani, Amanda Devine, Johnny Lo, Shih Ching Fu, Ian C. Dunican Jan 2022

Digging For Data: How Sleep Is Losing Out To Roster Design, Sleep Disorders, And Lifestyle Factors, Gemma Maisey, Marcus Cattani, Amanda Devine, Johnny Lo, Shih Ching Fu, Ian C. Dunican

Research outputs 2014 to 2021

Shift workers employed at a remote mining operation may experience sleep loss, impaired alertness, and consequently negative health and safety outcomes. This study determined the sleep behaviors and prevalence of risk for sleep disorders among shift workers; and quantified alertness for a roster cycle. Sleep duration was significantly less following; night shift by 77 ± 7 min and day shift by 30 ± 7 min. The wake after sleep onset was less by 23 ± 3 min for night shifts and 22 ± 3 min for day shifts (p < 0.05 for all). The prevalence of risk for sleep apnea was 31%, insomnia was 8%, and shiftwork disorder was 44%. Average alertness for all working hours was 75%. Shiftwork in remote mining operations is a significant factor that leads to sleep loss and reduced alertness, which is exacerbated by the high prevalence of risk for sleep disorders.


Development And Diagnostic Validation Of The Brisbane Evidence-Based Language Test, Alexia Rohde, Suhail A. Doi, Linda Worrall, Erin Godecke, Anna Farrell, Robyn O'Halloran, Molly Mccracken, Nadin Lawson, Rebecca Cremer, Andrew Wong Jan 2022

Development And Diagnostic Validation Of The Brisbane Evidence-Based Language Test, Alexia Rohde, Suhail A. Doi, Linda Worrall, Erin Godecke, Anna Farrell, Robyn O'Halloran, Molly Mccracken, Nadin Lawson, Rebecca Cremer, Andrew Wong

Research outputs 2014 to 2021

Purpose:

To describe the development and determine the diagnostic accuracy of the Brisbane Evidence-Based Language Test in detecting aphasia. Methods: Consecutive acute stroke admissions (n = 100; mean = 66.49y) participated in a single (assessor) blinded cross-sectional study. Index assessment was the ∼ 45 min Brisbane Evidence-Based Language Test. The Brisbane Evidence-Based Language Test is further divided into four 15–25 min Short Tests: two Foundation Tests (severe impairment), Standard (moderate) and High Level Test (mild). Independent reference standard included the Language Screening Test, Aphasia Screening Test, Comprehensive Aphasia Test and/or Measure for Cognitive-Linguistic Abilities, treating team diagnosis and aphasia referral …


Competing Worlds: The Private Lives Of Women Nurse Students And Gender Equity In Higher Education, Lesley Andrew, Ken Robinson, Leesa Costello, Julie Dare Jan 2022

Competing Worlds: The Private Lives Of Women Nurse Students And Gender Equity In Higher Education, Lesley Andrew, Ken Robinson, Leesa Costello, Julie Dare

Research outputs 2014 to 2021

© 2020 Society for Research into Higher Education. A longitudinal qualitative study of undergraduate women nursing students demonstrated the profound and pervasive influence of the heterosexual intimate relationship on their university engagement and achievement. Hitherto, the importance of women’s private lives have been underappreciated in the arenas of student equity and retention. The study showed that traditional ideas of gender held within the intimate relationship were highly detrimental to student autonomy and capacity to engage, and that the university’s organisation and delivery of the curriculum exacerbated the situation. Participants made personal sacrifices, which, while enabling continuation of their studies, were …