Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Electronic Thesis and Dissertation Repository

Discipline
Keyword
Publication Year

Articles 1 - 30 of 1745

Full-Text Articles in Medicine and Health Sciences

Examining The Socio-Economic And Gendered Structure Of Canada's Live-In Caregiver Program: A Qualitative Study Of Filipina Women's Health Experiences, Andrea Bobadilla Dec 2022

Examining The Socio-Economic And Gendered Structure Of Canada's Live-In Caregiver Program: A Qualitative Study Of Filipina Women's Health Experiences, Andrea Bobadilla

Electronic Thesis and Dissertation Repository

The primary aim of this critical ethnographic study was to examine how Filipina women in the Canadian live-in caregiver program (LCP) negotiate their own physical and mental well-being while managing the complex health needs of their clients. Using global care chain and postcolonial theoretical frameworks, I also sought to identify how multi-scalar forces including caregiving and migrant policies in Canada and South East Asia exacerbate pre-existing gendered and labour inequities faced by these women. The distressing impact of this precarious form of employment on family dynamics and relationships among family members in the Philippines was also explored. Data collection took …


Development Of An On-Call Assessment Tool For Competency-Based Surgical Training, Eric C. Mitchell Dec 2022

Development Of An On-Call Assessment Tool For Competency-Based Surgical Training, Eric C. Mitchell

Electronic Thesis and Dissertation Repository

Introduction: A central tenet of competency-based medical education is formative assessment of trainees. There are no assessments examining resident competence on-call, despite this being a significant component of resident training and characterized by less supervision compared to daytime.

Methods: A national survey was conducted to evaluate the state of assessment in Canadian Plastic and Reconstructive Surgery programs. An on-call assessment tool was developed based on a consensus group and was piloted over six months. Validity of the tool was examined through qualitative and quantitative methods.

Results: There were 63 tools completed across ten residents and seven staff physicians. Tool reliability …


Simulated And Experimental Approaches To The Development Of Novel Test Phantoms For Radiofrequency Heating Of Implanted Medical Devices, Amgad M. Louka Dec 2022

Simulated And Experimental Approaches To The Development Of Novel Test Phantoms For Radiofrequency Heating Of Implanted Medical Devices, Amgad M. Louka

Electronic Thesis and Dissertation Repository

Magnetic resonance imaging (MRI) has cemented itself as the gold standard for imaging of soft tissues and is only increasing in popularity. Given the rising number of MRI scanners and medical device being implanted into patients, it is becoming increasingly likely that patients undergoing MRI will have an implanted medical device (IMD). The presence of an elongated metallic IMD inside a scanner could result in dangerous interactions with the radiofrequency fields during MRI, thus some of these IMDs preclude the patients from being scanned.

Orthopedic devices typically fall into this category due to their high potential for RF induced heating, …


Noninvasive Quantification Of Tissue Sodium Concentration In The Kidney Disease Spectrum Using 23na Magnetic Resonance Imaging, Fabio R. Salerno Dec 2022

Noninvasive Quantification Of Tissue Sodium Concentration In The Kidney Disease Spectrum Using 23na Magnetic Resonance Imaging, Fabio R. Salerno

Electronic Thesis and Dissertation Repository

Chronic kidney disease (CKD), especially when requiring kidney replacement therapy (hemodialysis (HD) and peritoneal dialysis (PD)), is associated with extracellular water expansion with increased total body sodium. Sodium can also be accumulated in tissues independently of extracellular water. Sodium-23 magnetic resonance imaging (23Na MRI) can quantify the concentration of sodium nuclei in tissues. Applied to the human leg, quantification of tissue sodium concentrations mainly at the skin and muscle level is possible. We hypothesized that increased tissue sodium concentrations exert toxic effects in CKD and dialysis. We aimed to (1) compare tissue sodium concentrations in adults, children and …


Severe Lower Extremity Trauma In Ontario: A Linked Population-Based Analysis, Stephanie M. Kim Dec 2022

Severe Lower Extremity Trauma In Ontario: A Linked Population-Based Analysis, Stephanie M. Kim

Electronic Thesis and Dissertation Repository

Open tibia fractures (OTF) are a management challenge. Admission to a trauma center (TC) and a coordinated approach to bony fixation and soft-tissue reconstruction (STR) have been shown to improve outcomes. The objective of this study was to describe patients who had OTF in Ontario and analyze their outcomes. Linked population data pertaining to patients who had OTF between the years 2009-2020 were examined. Demographic information, admission location, and management course were collected. 4240 patients were found. The mean age was 47, and majority were males. Patients admitted to TC had greater proportion of having Injury Severity Score >15, and …


Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang Dec 2022

Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang

Electronic Thesis and Dissertation Repository

The considerable variation in the spatial distribution of cortical thickness changes has been used to parse heterogeneity in schizophrenia. We aimed to recover a ‘cortical impoverishment’ subgroup with widespread cortical thinning. We applied hierarchical cluster analysis to cortical thickness data of three datasets in different stages of psychosis and studied the cognitive, functional, neurochemical, language and symptom profiles of the observed subgroups. Our consensus-based clustering procedure consistently produced a subgroup characterized by significantly lower cortical thickness. This ‘cortical impoverishment’ subgroup was associated with a higher symptom burden in a clinically stable sample and higher glutamate levels with language impairments in …


Encouraging Movement Opportunities Through Theory-Informed Video Education In Undergraduate Students: The Move Study, Carmen T. Labadie Nov 2022

Encouraging Movement Opportunities Through Theory-Informed Video Education In Undergraduate Students: The Move Study, Carmen T. Labadie

Electronic Thesis and Dissertation Repository

This mixed methods randomized control trial explored the impact of a tailored, Health Belief and Transtheoretical Model informed educational video on undergraduate students’: (1) motivational readiness, self-efficacy, and decisional balance about changing sedentary behaviour; (2) levels of sedentary time; and (3) perceptions of sedentary behaviour over time and when compared to a control condition. Students (N = 160) were randomly assigned to the intervention or control group. Participants completed: two previously validated questionnaires at baseline, immediate post-intervention, and one-month follow-up; and open-ended questions at post-intervention (intervention group only). Linear mixed models and inductive content analysis were used. Significant differences …


A Long-Term Follow-Up Of The Stability Study: Multicenter Rct Comparing Anterior Cruciate Ligament Reconstruction With And Without Lateral Extra-Articular Tenodesis In Individuals At High Risk Of Graft Failure, Katelyn M. Inch Nov 2022

A Long-Term Follow-Up Of The Stability Study: Multicenter Rct Comparing Anterior Cruciate Ligament Reconstruction With And Without Lateral Extra-Articular Tenodesis In Individuals At High Risk Of Graft Failure, Katelyn M. Inch

Electronic Thesis and Dissertation Repository

One hundred and ninety-six patients at the Fowler Kennedy Sport Medicine Clinic (FKSMC) undergoing anterior cruciate ligament (ACL) reconstruction (ACLR) were randomized as part of the multi-center STABILITY study to receive either an isolated ACLR or ACLR with a lateral extra-articular tenodesis (LET). The STABILITY study followed these patients up to two years postoperative, and a long-term follow-up protocol was initiated afterwards. Eighty-two patients from this center were seen at three, five and seven years postoperative as part of a long-term follow-up. Our primary outcome was a composite outcome of instability and graft failure. Secondary outcomes included patient-reported outcome measures …


The Effect Of Oral And Topical Antibiotics On Foreskin Inflammation And Hiv Target Cells In Ugandan Men., Zhongtian (Eric) Shao Nov 2022

The Effect Of Oral And Topical Antibiotics On Foreskin Inflammation And Hiv Target Cells In Ugandan Men., Zhongtian (Eric) Shao

Electronic Thesis and Dissertation Repository

Penile circumcision reduces HIV susceptibility by up to 60% in men; however, many men prefer to remain uncircumcised for personal or cultural reasons. Penile circumcision protects against HIV by reducing anaerobic bacteria on the penis. Penile anaerobes cause local inflammation and the recruitment of HIV-susceptible CD4+CCR5+ cells, increasing the likelihood that exposure to HIV during intercourse results in infection. To determine if a non-surgical intervention can reduce penile anaerobes and HIV target cells, we randomized men to antimicrobial treatment prior to circumcision. To be able to quantify the effect of antimicrobials, we developed a novel deep-learning algorithm to quantify HIV …


A Framework For Stable Robot-Environment Interaction Based On The Generalized Scattering Transformation, Kanstantsin Pachkouski Nov 2022

A Framework For Stable Robot-Environment Interaction Based On The Generalized Scattering Transformation, Kanstantsin Pachkouski

Electronic Thesis and Dissertation Repository

This thesis deals with development and experimental evaluation of control algorithms for stabilization of robot-environment interaction based on the conic systems formalism and scattering transformation techniques. A framework for stable robot-environment interaction is presented and evaluated on a real physical system. The proposed algorithm fundamentally generalizes the conventional passivity-based approaches to the coupled stability problem. In particular, it allows for stabilization of not necessarily passive robot-environment interaction. The framework is based on the recently developed non-planar conic systems formalism and generalized scattering-based stabilization methods. A comprehensive theoretical background on the scattering transformation techniques, planar and non-planar conic systems is presented. …


Exploration Of The Pathophysiological Mechanisms Underlying Hemodialysis Associated Cardiac Ischemic Injury, Lisa Yun Jeong Hur Nov 2022

Exploration Of The Pathophysiological Mechanisms Underlying Hemodialysis Associated Cardiac Ischemic Injury, Lisa Yun Jeong Hur

Electronic Thesis and Dissertation Repository

Hemodialysis (HD) provides life-saving treatment in individuals with kidney failure. However, HD is associated with poor quality of life and extremely high mortality rates mainly caused by cardiovascular disease due to heart failure and sudden cardiac death. Standard pharmacological treatment developed within the non-kidney disease community are largely ineffective in HD patients because of the difference in pathophysiology of cardiovascular mortality. HD treatment causes hypotension and recurrent ischemic injury to multiple vascular beds including the heart, leading to heart failure. These injuries can be abrogated by improving the patient’s tolerability of the treatment. To apply interventions that may improve hemodynamic …


The Clinical Value Of Oculomotor Assessments Across The Continuum Of Concussion, Dillon Richards Nov 2022

The Clinical Value Of Oculomotor Assessments Across The Continuum Of Concussion, Dillon Richards

Electronic Thesis and Dissertation Repository

Concussions are complex conditions that are difficult to manage medically. Variations in symptom presentation, intricate neurophysiological processes, and the availability of a variety of possible assessment tools may contribute to this complexity. Clinicians must use a broad approach, employing both subjective symptom assessment and objective assessments to confirm a diagnosis and/or monitor progression and recovery. Oculomotor function after concussion may be an important indicator of injury, given the interconnectedness of oculomotor function, vestibulo-ocular and visual systems, and even cognition. Oculomotor function may be assessed objectively or indirectly using patient-reported symptom checklists as part of subjective assessments. One way of objectively …


Decompression Vs. Decompression And Fusion In Cauda Equina Syndrome Secondary To Massive Lumbar Disc Herniation, Ruheksh Raj Nov 2022

Decompression Vs. Decompression And Fusion In Cauda Equina Syndrome Secondary To Massive Lumbar Disc Herniation, Ruheksh Raj

Electronic Thesis and Dissertation Repository

Posterior spinal surgery through either a decompression or additional fusion procedure is the widely accepted standard of care for patients presenting with cauda equina syndrome (CES) secondary to massive disc herniation. A plethora of literature has been published regarding post- surgical outcome, particularly in regards to improvement of lower sacral nerve symptoms in relation to timing of surgery. There is a paucity of data with regards to long term clinical outcomes in patients between the decompression and decompression and fusion groups. We initially hypothesized was that there would be no longer term clinical differences in outcome between the two groups, …


Internet-Delivered Cognitive Behavioural Therapy For People With Mild Traumatic Brain Injury: A Feasibility Study, Ujjoyinee France Barua Nov 2022

Internet-Delivered Cognitive Behavioural Therapy For People With Mild Traumatic Brain Injury: A Feasibility Study, Ujjoyinee France Barua

Electronic Thesis and Dissertation Repository

Individuals with mild traumatic brain injury (mTBI) can experience high levels of emotional distress, leading to decreased quality of life and increased health care costs. Bowen's feasibility framework was used to examine the feasibility, acceptability, and limited efficacy of an innovative clinician-guided internet-delivered cognitive behavioural therapy program (ICBT) specialized for people with mTBI to improve their wellbeing. The data illustrated strong adherence and program satisfaction from participants. Likewise, statistically and clinically significant changes in symptoms of unhappiness and anxiety were found, along with improved self-efficacy and quality of life. The findings of this study contribute new knowledge to the emerging …


The Lived Experiences Of Pain And Fatigue In Persons Living With Neurological Conditions: A Phenomenological Study, Lauren L. Kane Oct 2022

The Lived Experiences Of Pain And Fatigue In Persons Living With Neurological Conditions: A Phenomenological Study, Lauren L. Kane

Electronic Thesis and Dissertation Repository

Purpose: The aim of the study was to understand the experiences and impact of pain and fatigue and to further explore the relationship between participants' descriptions of their lived experiences with these phenomena within and across multiple sclerosis, Parkinson's disease, and cerebral palsy. Methods: Semi-structured interviews were used to interview nine participants about their experiences of living with pain and fatigue in their respective conditions. A new phenomenological approach was adopted, and data was analyzed inductively using interpretive phenomenological analysis. Results: Three final themes including a lack of understanding, negative perceptions of pain and fatigue, and coping strategies used to …


Western Diet-Like Culture Conditions And Oxidative Stress On A Cell Model Of Non-Alcoholic Fatty Liver Disease, Celina M. Valvano Oct 2022

Western Diet-Like Culture Conditions And Oxidative Stress On A Cell Model Of Non-Alcoholic Fatty Liver Disease, Celina M. Valvano

Electronic Thesis and Dissertation Repository

Non-alcoholic fatty liver disease (NAFLD) is a major health burden in the Western world, as the Western diet (WD) appears to be the driving force of this disease. However, the individual contributions of the diet and the impacts of their individual metabolism are currently ill-defined. This study used HepG2 cells to understand the impact of the individual components of WD in early NAFLD development under basal insulin levels. Specifically, nutrient-induced changes in reactive oxygen species (ROS) and signaling pathways, such as sterol regulatory element binding proteins (SREBPs), were examined to identify the root cause of steatosis development. High-fat and WD-exposed …


A Fast Voxel-Based 3d Dose Convolution Method For Personalized Targeted Radionuclide Therapy Of Prostate Cancer Patients, Chidera Opara Oct 2022

A Fast Voxel-Based 3d Dose Convolution Method For Personalized Targeted Radionuclide Therapy Of Prostate Cancer Patients, Chidera Opara

Electronic Thesis and Dissertation Repository

Targeted radionuclide therapy (TRT) is an effective treatment for metastatic prostate cancer. This thesis develops a convolution-based dosimetric method for TRT and validates its performance against a Monte Carlo (MC) simulation method, egs_mird, developed in our laboratory.

The research completed includes: 1) validating egs_mird by generating dose point kernels (DPKs) for 90Y, 131I and 177Lu and comparing them with MCNP4C, PENELOPE and GEANT4 DPK in literature, and 2) comparing TRT dosimetry of prostate cancer patients obtained using the convolution method and egs_mird.

egs_mird DPKs for 90Y and 131I agreed with those from other MC codes. …


Perspectives Of Middle Eastern Immigrant Parents Regarding Accessing Healthcare Services For Children During The Covid-19 Pandemic In London, Ontario, Sarvenaz Mehrabi Oct 2022

Perspectives Of Middle Eastern Immigrant Parents Regarding Accessing Healthcare Services For Children During The Covid-19 Pandemic In London, Ontario, Sarvenaz Mehrabi

Electronic Thesis and Dissertation Repository

Background: During the COVID-19 pandemic, immigrants have been disproportionally affected and faced difficulties in accessing healthcare services. While it has been reported that the rate of pediatric healthcare utilization decreased during the COVID-19 pandemic, the reasons behind this decline are unclear. It has been suggested that immigrant children might be affected by the COVID-19 pandemic restrictions regarding accessing healthcare services. This study aims to understand the Middle Eastern immigrant parents’ perspectives regarding their access to healthcare services for their children in the London, Ontario, area during the COVID-19 pandemic.

Methods: This qualitative study was conducted with an interpretive description methodology …


Multimorbidity And Cognition Among Canadian Older Adults: A Three-Decade Perspective, Juan Camilo Vargas Gonzalez Oct 2022

Multimorbidity And Cognition Among Canadian Older Adults: A Three-Decade Perspective, Juan Camilo Vargas Gonzalez

Electronic Thesis and Dissertation Repository

Background: Scarce information exists about whether the relationship between multimorbidity and cognitive decline has changed over the past decades.

Objectives: 1) To summarize knowledge about the association of multimorbidity and cognitive decline by performing a systematic review. 2) To estimate the association between multimorbidity in two cohorts selected three decades apart. 3)To identify which multimorbidity combinations have the strongest associations with cognitive decline 4) To identify protective factors that reduce the risk of cognitive decline in the presence of multimorbidity.

Methods: We performed a systematic review following the PRISMA statement. We then addressed objectives 2-4 by analyzing data from two …


Technical Adaptations For Cardiac Sodium Mri, Taylor L. Marcus Oct 2022

Technical Adaptations For Cardiac Sodium Mri, Taylor L. Marcus

Electronic Thesis and Dissertation Repository

Cardiac sodium (Na+) MRI has the potential to unveil relationships between chronic kidney disease (CKD) and cardiovascular disease (CVD). Unfortunately, this modality requires many technical adaptations before it’s possible to extract and compare image data between individuals. This study investigated whether cardiac electrocardiogram (ECG) gating could improve image quality, and whether a uniform phantom could increase signal uniformity if a surface coil is used to acquire the image. Healthy participants were imaged with a custom-built surface coil and 3.0-T MR system. Cardiac gated images presented with a decreased signal-to-noise ratio (SNR), but intensity correction significantly increased image signal …


Multi-Scale Computational Modeling Of Coronary Blood Flow: Application To Fractional Flow Reserve., Jermiah Joseph Sep 2022

Multi-Scale Computational Modeling Of Coronary Blood Flow: Application To Fractional Flow Reserve., Jermiah Joseph

Electronic Thesis and Dissertation Repository

Introduction. Fractional flow reserve (FFR) is presently an invasive coronary clinical index. Non-invasive CT imaging combined with computational coronary flow modelling may reduce the patient’s burden of undergoing invasive testing.

Research statement. The ability to obtain information of the hemodynamic significance of detected lesions would streamline decision making in escalation to invasive angiography.

Methods. A reduced order (lumped parameter) model of the coronary vasculature was further developed. The model was used in the assessment of the roles of structure and function on the FFR. Sophisticated methods were used to elicit numerical

solutions. Further, CT imaging (n = …


Determination Of The Protective Capacity Of Hand Wraps In Combat Athletes Using Force Analysis, Eva M. Gusnowski Sep 2022

Determination Of The Protective Capacity Of Hand Wraps In Combat Athletes Using Force Analysis, Eva M. Gusnowski

Electronic Thesis and Dissertation Repository

Upper extremity injuries are common in combat athletes, and are highest in the hand/wrist. Although protective hand gear is used, there is a paucity of research investigating its effectiveness. This study addressed this knowledge gap by measuring the level of force transmitted to the hand during striking using two types of hand wraps. This prospective cross over study included six combat athletes. A load cell was placed over the proximal phalanges/metacarpophalangeal joints and was used to measure sustained peak force during striking while covered with either standard linear or gel-reinforced hand wraps and boxing gloves. The gel reinforced wraps consistently …


Adaptation With Injury, Family Role Responsibilities, & Social Support After Distal Radius Fracture (Drf), Hajra Batool Sep 2022

Adaptation With Injury, Family Role Responsibilities, & Social Support After Distal Radius Fracture (Drf), Hajra Batool

Electronic Thesis and Dissertation Repository

This study is a qualitative interpretive descriptive study aimed at elucidating the impact of distal radius fracture (DRF) on patients' activities of daily living (ADLs), professional and familial duties, and social support during the healing process. The study focuses on fracture healing during the immobilization phase of injury. This study lies in the constructivist paradigm employing the interpretive description method. A total of 20 participants with DRF in casts were recruited by purposeful sampling from the Hand & Upper limb Centre, St. Joseph’s Hospital enrolled and interviewed over the telephone. Data was analyzed by Braun and Clarke’s Thematic Analysis Approach. …


Anatomical And Functional Lung Imaging With Volumetric Computed Tomography In Non-Small Cell Lung Cancer, Heather Young Aug 2022

Anatomical And Functional Lung Imaging With Volumetric Computed Tomography In Non-Small Cell Lung Cancer, Heather Young

Electronic Thesis and Dissertation Repository

Non-small cell lung cancer (NSCLC) is one of the most diagnosed cancers in Canada, and the leading cause of cancer deaths. A significant challenge in treating NSCLC is balancing aggressive treatment with the potentially severe side effects. In radiation therapy, the management of respiratory motion and the risks of radiation-induced lung injury (RILI) pose significant challenges. 4-dimensional computed tomography (4D-CT) is an important part of motion management, but images often suffer from motion-induced artifacts. Volumetric CT scanners with wide axial field-of-view (aFOV) may reduce these artifacts and present an opportunity to advance CT-based functional lung imaging.

Chapter 2 presents a …


Development Of Psychoacoustic Screening Tests For Hearing Assessments, Minh Vu Duong Aug 2022

Development Of Psychoacoustic Screening Tests For Hearing Assessments, Minh Vu Duong

Electronic Thesis and Dissertation Repository

The evaluation of suprathreshold listening abilities in audiological assessment is often minimized despite the valuable insight it produces about auditory discrimination skills. These capabilities can be assessed from psychoacoustic tests. However, measuring these abilities requires a significant amount of time. Therefore, screening tests were developed for frequency discrimination, gap detection, and amplitude modulation tests to identify individuals for whom these skills are most likely to be useful. The purpose of this project was to determine the ability of this screening tool to predict good performers and determine who is likely to have reduced skills and require full threshold assessment. Thirty …


Atrial Fibrillation And Cognitive Decline: A Computational Hemodynamics Investigation, Timothy J. Hunter Aug 2022

Atrial Fibrillation And Cognitive Decline: A Computational Hemodynamics Investigation, Timothy J. Hunter

Electronic Thesis and Dissertation Repository

Background: Atrial fibrillation (AF) is a prevalent cardiac disease which has been associated with increased risk of dementia and cognitive decline. We hypothesize that atrial fibrillation leads to regional transient hypoperfusion events in the brain, and that geometric variations in the arterial structure called the Circle of Willis (CoW) play a role in these events.

Methods: A computational model was developed to simulate cerebral blood flow in six common variations of the CoW. Risk was assessed based on frequency of beat-wise regional hypoperfusion events during AF, and sensitivity analysis was performed with respect to this model output.

Results …


Validity Of Quality Of Life Measurement In Economic Evaluations In Total Joint Replacement: Agreement Between Western Ontario And Mcmasters' Osteoarthritis Index (Womac) And The Euroqol 5d (Eq-5d) Utility Scores, Sanju Valamparampil Aug 2022

Validity Of Quality Of Life Measurement In Economic Evaluations In Total Joint Replacement: Agreement Between Western Ontario And Mcmasters' Osteoarthritis Index (Womac) And The Euroqol 5d (Eq-5d) Utility Scores, Sanju Valamparampil

Electronic Thesis and Dissertation Repository

Health economic evaluations are commonly conducted through a cost-utility analysis, where health benefits are measured using utility scores. A common utility measure is the European Quality of Life (EQ-5D). Osteoarthritis (OA) research studies commonly use disease-specific quality of life tools such as the Western Ontario and McMaster’s Universities Osteoarthritis Index (WOMAC) to derive utility scores, but the validity of this method is unknown. This research aims to determine the agreement between utility scores derived from WOMAC and the EQ-5D surveys among patients who have undergone Total Joint Replacement (TJR). To estimate the agreement, we calculated an intraclass correlation coefficient (ICC) …


Respiratory Pattern Analysis For Covid-19 Digital Screening Using Ai Techniques, Annita Tahsin Priyoti Aug 2022

Respiratory Pattern Analysis For Covid-19 Digital Screening Using Ai Techniques, Annita Tahsin Priyoti

Electronic Thesis and Dissertation Repository

Corona Virus (COVID-19) is a highly contagious respiratory disease that the World Health Organization (WHO) has declared a worldwide epidemic. This virus has spread worldwide, affecting various countries until now, causing millions of deaths globally. To tackle this public health crisis, medical professionals and researchers are working relentlessly, applying different techniques and methods. In terms of diagnosis, respiratory sound has been recognized as an indicator of one’s health condition. Our work is based on cough sound analysis. This study has included an in-depth analysis of the diagnosis of COVID-19 based on human cough sound. Based on cough audio samples from …


Biomechanical Characterization Of Semi-Rigid Constructs And The Potential Effect On Proximal Junctional Kyphosis In The Thoracic Spine, Chloe Cadieux Aug 2022

Biomechanical Characterization Of Semi-Rigid Constructs And The Potential Effect On Proximal Junctional Kyphosis In The Thoracic Spine, Chloe Cadieux

Electronic Thesis and Dissertation Repository

Long spinal fusions are the mainstay of treatment in adult spinal deformity; however, proximal junctional kyphosis (PJK) is a common and potentially catastrophic complication that can occur following this procedure. It has been hypothesized that using semi-rigid constructs at the superior aspect of the instrumentation may decrease this complication. The objective of this thesis was to determine if there is a biomechanical advantage between various semi-rigid constructs utilized in long spinal fusions to help decrease the risk of PJK. Nine human cadaveric spines (T1 – T12) instrumented with the standard all-pedicle-screw construct (APS) were compared to various semi-rigid constructs including …


Men Under Microscopes: “Medical Gaze” And Homeostasis In Victorian Realist Literature, Nida Rashid Aug 2022

Men Under Microscopes: “Medical Gaze” And Homeostasis In Victorian Realist Literature, Nida Rashid

Electronic Thesis and Dissertation Repository

This thesis aims to explore the following questions implicit in four Victorian novels: is the relationship between science and humanities continuously at odds due to fundamental differences in philosophies? Can an understanding of how medicine transformed from an art to a science help bridge the gap between the arts and sciences? As medicine transformed into a science in the nineteenth century, it adopted three key innovations: first, Claude Bernard’s experimental method; second, what Michel Foucault later came to conceive of as the “medical gaze”; and third, Bernard’s theory of homeostasis. The thesis traces the changes in medicine as inflected across …