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Research News: 2013, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

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Pengaruh Latihan Fartlek Dengan Treadmill Dan Lari Di Lapangan Terhadap Daya Tahan Kardiorespirasi, Maya Kurnia, B.M. Wara Kushartanti

Jurnal Keolahragaan

Tujuan penelitian ini untuk mengungkapkan pengaruh dari latihan fartlek dengan treadmill, latihan fartlek dengan lari di lapangan, dan kapasitas vital paru terhadap daya tahan kardiorespirasi. Penelitian ini menggunakan desain eksperimen faktorial 2 x 2. Data dikumpulkan menggunakan tes daya tahan kardiorespirasi (tes Cooper 12 menit), dihitung jarak maksimal yang dapat ditempuh dalam waktu 12 menit tersebut. Hasil penelitian adalah sebagai berikut: (1) Ada perbedaan daya tahan kardiorespirasi antara kelompok latihan fartlek dengan treadmill dan kelompok latihan fartlek dengan lari di lapangan. Daya tahan kardiorespirasi kelompok latihan fartlek dengan lari di lapangan menunjuk-kan pengaruh lebih baik dibandingkan kelompok latihan fartlek …

The Relationships Between Using The Rating Of Perceived Exertion, Metabolic Equivalent And Maximum Heart Rate At Ventilatory Threshold Into Determine Appropriate Exercise Prescription For Intensity In Obese Diabetic Patients: A Preliminary Study, Yan-Wen Chen, Francois Liang, Sen-Wei Tsai, Shih-Yi Lin, I. T. Lee, Sheu-Chen Liu, Shin-Shan Lu

Rehabilitation Practice and Science

Background: The rating of perceived exertion (RPE), metabolic equivalent (MET) and maximum heart rate (HRmax) at ventilatory threshold (VT) are commonly used methods as physiological parameters for monitoring exercise intensity. However, the appropriate levels of training intensity for obese type 2 diabetic diabetes mellitus (type 2 DM) patients have not been established.Purpose: To examine the parameters in obese Type 2 DM patients at ventilatory threshold, the exercise capacity of obese Type 2 DM patients, and to determine the appropriate levels of exercise intensity for exercise prescription in obese type 2 DM patients was investigated.Methods: Twenty obese type 2 DM patients …

台灣復健醫學雜誌通訊繼續教育測驗題, The Editors

Rehabilitation Practice and Science

No abstract provided.

Early Rehabilitation Intervention Can Reduce The Admission Duration Of Rotator Cuff Repair-Introducing The Rehabilitation Protocol, Kun Hung, Bu-Yu Han, Jian-Huang Guo, Tai-Yi Wu, Shu-Hua Lin, Chung-Sheng Ho, Yu-Ting Hsieh

Rehabilitation Practice and Science

Currently, there is no standardized rehabilitation protocol for postoperative rotator cuff repair, particularly at acute stage. The purpose of the study was to evaluate the efficiency of preoperative patient education and acute stage rehabilitation, which may contribute in constructing a suitable rehabilitation protocol. The prospective observational study was conducted in a local teaching hospital over a period of 3 months. Twenty patients including 11 men and 9 women with a history of supraspinatus tear were enrolled in this study. The rehabilitation protocol involved preoperative patient education, postoperative proper positioning, passive range of motion exercises, and the usage of continuous passive …

Compressive Femoral Neuropathy Caused By Iliopsoas Muscle Hematoma: A Casereport, Szu-Hung Tsao, Yu-Ting Hsieh, Tai-Yi Wu, Shu-Hua Lin

Rehabilitation Practice and Science

Femoral neuropathy is uncommon compared with other mononeuropathies. We report a case of femoral neuropathy in a 53-year-old man who has cardiovascular disease and took Coumadin for 8 years. He has left lower extremity pain and weakness because of femoral nerve and lumbar plexus compression caused by an iliopsoas hematoma, which resulted from a period of prolonged bleeding. The patient’s condition improved after surgery and rehabilitation. We also reviewarticle the anatomy and pathophysiology of the femoral nerve, the clinical presentation of femoral neuropathy, the diagnostic tools used, the treatment method, and the prognosis.

Abnormal Heart Rate Recovery After 6-Minute Walk Test Is Associated With Diabetic Retinopathy In Patients With Type 2 Diabetes Mellitus: A Preliminary Study, Yu-Shiang Huang, Shu-Chen Chang, Shu-Fang Lee, Meng-Shuo Shen, Huey-Jen Chen, Miao-Ming Chen

Rehabilitation Practice and Science

Diabetic retinopathy is associated with cardiac autonomic dysfunction in patients with diabetes mellitus. Abnormal heart rate recovery (HRR) after exercise can be used as a marker of reduced cardiac autonomic function in submaximal and symptom-limited exercise stress testing. The 6-minute walk test (6MWT) is considered as a submaximal test that is more appropriate to assess the capacity of performing activities of daily living, and can be applied to a variety of patients in clinical settings without the need of sophisticated equipment. The aim of the present study was to investigate the association of diabetic retinopathy with HRR after 6MWT in …

Minimal Detectable Change And Responsiveness Of The 5-Item Barthel Index In Patients With Stroke, Wen-Shian Lu, Ya-Chen Lee, Fuh-Chour Twu, Ching-Lin Hsieh

Rehabilitation Practice and Science

Background and Purpose: A concise measurement tool can be easily accepted by clinicians. The 5-item Barthel Index (BI-5) has only 5 items and thus the potential to be used routinely in clinical settings. However, the minimal detectable change (MDC) and responsiveness of the BI-5 have not been verified sufficiently, limiting the interpretability of the change scores of the BI-5. The purposes of this study were to investigate the MDC and responsiveness of the BI-5 in patients with stroke and to compare the MDC and responsiveness of the BI-5 to those of the original BI.Methods: This study used secondary data analysis. …

Evaluation Of Pediatric Subjects With Swallowing Disorder Part I: Physiology And Pathology, Luh Karunia Wahyuni, Chan-Wei Lin, Tyng-Guey Wang

Rehabilitation Practice and Science

Feeding and swallowing disorders are important issues in a pediatric population, which may lead to malnutrition, dehydration, or increased risk of pulmonary complications. Pediatric dysphagia is more complex than adult dysphagia in some aspects because it includes developmental progress in anatomical structures and physiological functions. To manage pediatric feeding and swallowing disorders, comprehensive knowledge regarding the development of normal swallowing and of the pathologies of common diseases related to pediatric dysphagia are necessary. In this article, we will reviewarticle the pediatric swallowing structures and physiology, and address the feeding and swallowing problems in common pediatric diseases, including cerebral palsy, cleft …

Evaluation Of Pediatric Subjects With Swallowing Disorder Part Ii, Luh Karunia Wahyuni, Ming-Yen Hsiao, Hsing-Kuo Wang, Tyng-Guey Wang

Rehabilitation Practice and Science

The characteristics of pediatric swallowing, anatomical differences between pediatrics and adults, and swallowing problems in common pediatric diseases had been introduced in Part 1 of the article. The common methods for evaluation of pediatric swallowing are discussed in this part. The evaluation of swallowing function in pediatric patients is a great clinical challenge. It requires a team approach, an integration of multiple disciplines, and instrumental evaluations for establishing a diagnosis and developing an appropriate management plan. This article provides an introduction of the vital concept of clinical bedside evaluation and instrumental evaluation including the videofluoroscopic swallow study (VFSS), fibroptic endoscopic …

Incidental Finding Of A Simple Dysraphic State Of A Closed Spinal Dysraphism And Tethered Cord In An Adult Patient With Low Back Pain: A Casereport, Lin-Chien Lee, Hung-Fu Lee, Fu-Kong Lieu

Rehabilitation Practice and Science

The recognition of a closed spinal dysraphism without a subcutaneous mass and cutaneous stigmata depends on the development of relevant neurological and urological symptoms and signs. It can also be an incidental finding when symptoms that do not originate from it are investigated. We describe a 39-year-old man who presented with spondylolysis-related low back pain. Plain film showed posterior spina bifida of S1 and magnetic resonance imaging of the L-spine revealed one intradural lipoma at the L5 level and cord tethering. Conservative treatment was suggested because no relevant symptoms or signs of a mass effect of the lipoma or tethered …

Exploring The Possible Effects Of Mountaineering Activities On Sports Injuries, Body Composition And Thigh Muscle Function, Yi-Ting Fang, Chen-Liang Chou, Yi-Cheng Chen, Hong-Jen Chiou, Jin-Jong Chen, Hsuci-Chen Lee, Yi-Fen Shih

Rehabilitation Practice and Science

Background: Mountaineering and hiking have become popular activities recently, but related research in Taiwan has focused mainly on physiological reactions, much more than on the musculoskeletal system. However, the results of studies from abroad cannot be directly transferred because of the unique mountain and forest environment in Taiwan. In addition, chronic mountaineering injuries and derivative benefits in terms of specific physical performances still await further study. Therefore, it is important to investigate the possible relationship between mountaineering activities and musculoskeletal or knee function changes. Purpose: This study seeks to compare the differences in sports injuries, body composition and thigh muscle …

Health-Related Quality Of Life And Hemophilic Arthropathy In Hemophilia Patients, Chih-Ya Chang, Hui-Yi Su, Yung-Tsan Wu, Yu-Chin Chen, Liang-Cheng Chen, Shin-Tsu Chang, Tsung-Ying Li

Rehabilitation Practice and Science

Introduction: Hemophilia is an X-linked recessive bleeding disorder caused by a deficiency of coagulation factor VIII (hemophilia A) or IX (hemophilia B). The prevalence of hemophilia is approximately 1 per 105 in the general population. Repeated joint bleeding leads to chronic synovitis, cartilage damage, and bone destruction, yielding reduced range of motion (ROM), painful joints, and muscle atrophy. Hemophilic arthropathy can negatively influence perceptions of health-related quality of life (HRQOL) among hemophilia patients. This study explored the correlation between hemophilic arthropathy and HRQOL among hemophilia patients in Taiwan. Methods: The participants comprised 86 patients enrolled from a hemophilia center. We …

The Treatment Of Pain With Heel Fat Pad Syndrome By Hyaluronic Acid Injection: A Casereport, Wei-Han Chang, Chih-Kuan Wu, Yu-Cheng Pei, Chih-Chi Chen, Alice Mk Wong

Rehabilitation Practice and Science

Plantar fasciitis and heel fat pad syndrome are two of the most common causes of plantar heel pain. Because the clinical symptoms and signs are similar, the differential diagnosis between plantar fasciitis and heel fat pad syndrome is important for proper treatment. Unfortunately, conservative treatment strategies are less effective for plantar heel pain caused by heel fat pad syndrome. We present here a 56-year-old male patient with bilateral plantar heel pain that was especially severe in the left foot. We gave him an injection of 2 ml high-concentration, cross-linked hyaluronic acid into the deep derma of the painful heel pad …

Effects Of Low Power Laser On Pain And Balance Dysfunction Caused By Periostitis Of Lower Limb: A Case Series, Hui-Yi Su, Yu-An Hu, Wei-Chun Hsu, Shih-Chi Li, Shin-Tsu Chang

Rehabilitation Practice and Science

Periostitis of the lower limb is a common problem in sports injury, and an appropriate treatment option is required for this medical issue. The purpose of this study was to assess pain reduction and functional improvement after low power laser therapy in the lower limbs with periostitis. A total of 29 adults (20-40 year-old) who had periostitis at our outpatient clinic were enrolled. The diagnosis of periostitis in the lower limbs was confirmed by skeletal scintigraphy. The treatment protocol adopted rehabilitation intervention involving low power laser treatment 3 times a day for 5 days, and a low-energy dosage of 1.4 …

Lower Extremity Prostheses Related Biomechanics, Valeria Chiu, Ming-Chuan Lin

Rehabilitation Practice and Science

During heel strike, a prosthetic foot must perform ground-reaction force shock absorption, and thereafter, must provide control of the smooth-rhythm plantar flexion movement. During the midstance phase, the foot must provide the controlled advancement of the tibia. During the terminal stance, the anterior part of the foot must act as a hard rocker to provide progression and roll over the toe and to allow center of gravity switching to the opposite site as the tibia advances. The biomechanics of the four-bar linkage knee simulates the motion of the actual human knee joint. It can be discussed by analyzed by five …

Effectiveness Of Resistance (Strength) Training For Patients With Chronic Heart Failure, Yan-Wen Chen

Rehabilitation Practice and Science

The recent advancements in cardiac disease treatments have remarkably enhanced the survival rate of patients with chronic heart failure. In patients with exercise intolerance, the accompanied peripheral myopathy plays an important role. Resistance training is beneficial for musculoskeletal function in patients with chronic heart failure. However, the left ventricular myocardial remodeling progression and the hemodynamic response are controversial. Some studies showed that for those with stable heart failure (New York Heart Association functional classes I to III level), the adequate resistance training was beneficial in improvement of aerobic capacity, muscle histology, metabolic function, and left ventricular ejection fraction. In this …

Lipoma Arborescens On Mr Imaging And The Associated Lesions: A Reviewarticle Of 78 Cases, Cheng-Yuan Lin, Cheng-Ming Chiu, Tsung-Ching Lin, Shun-Lung Li, Chia-Yi Shang, Yu-Chiang Chen

Rehabilitation Practice and Science

Objective: To identify the different morphologic patterns of lipoma arborescens (LA) and the associated lesions on magnetic resonance (MR) imaging and to evaluate their clinical implication.Methods: We conducted a retrospective reviewarticle of the MR images and medical records of 78 patients diagnosed with LA of the knee (n=73) and shoulder (n=5). The diagnosis of LA was confirmed by the histologic findings in two cases and by the characteristic MR imaging features in the other 76.Results: A typical pattern of villous lipomatous proliferation of the synovium was identified on MR imaging in all cases, as a typical frond-like pattern in 38% …

It’S Playoff Time – And A Reminder That Brain Health Comes First, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Effects Of Nesting Environment On Neonatal Hypoxic-Ischemic Injury, Laura Grace Rollins

Graduate Masters Theses

Term neonates with hypoxic-ischemic (HI) injury are at risk for devastating neurological sequelae. The objective of this study is to determine if altering the early environment for maternal care-taking impacts the immediate and long-term sequelae of HI offspring. The Rice-Vannucci model was used to induce HI in postnatal day (PND) 7 Long-Evans pups. Litters were assigned to a closed nest (CN) or normal standard housing (SH) condition. Neurobehavioral development, cognitive ability, and stress response were assessed to establish any benefits of the CN condition. Finally, postmortem brain tissue was analyzed for morphometric markers of injury.

Black Hispanic And Black Nonhispanic Breast Cancer Survival Data Analysis With Half-Normal Model Application, Hafiz Mohammad Rafiqullah Khan, Anshul Saxena, Veronica Vera, Faheema Abdool-Ghany, Kemesha Gabbidon, Nancy Perea Perea, Ts Stewart, Venkataraghavan Ramamoorthy Ramamoorthy

USF St. Petersburg Campus Faculty Publications

Background: Breast cancer is the second leading cause of cancer death for women in the United States. Differences in survival of breast cancer have been noted among racial and ethnic groups, but the reasons for these disparities remain unclear. This study presents the characteristics and the survival curve of two racial and ethnic groups and evaluates the effects of race on survival times by measuring the lifetime data-based half-normal model. Materials and Methods: The distributions among racial and ethnic groups are compared using female breast cancer patients from nine states in the country all taken from the National Cancer Institute’s …

Obesity Reduces Left Ventricular Strains, Torsion, And Synchrony In Mouse Models: A Cine Displacement Encoding With Stimulated Echoes (Dense) Cardiovascular Magnetic Resonance Study, Sage P. Kramer, David K. Powell, Christopher M. Haggerty, Cassi M. Binkley, Andrea C. Mattingly, Lisa A. Cassis, Frederick H. Epstein, Brandon K. Fornwalt

Pediatrics Faculty Publications

BACKGROUND: Obesity affects a third of adults in the US and results in an increased risk of cardiovascular mortality. While the mechanisms underlying this increased risk are not well understood, animal models of obesity have shown direct effects on the heart such as steatosis and fibrosis, which may affect cardiac function. However, the effect of obesity on cardiac function in animal models is not well-defined. We hypothesized that diet-induced obesity in mice reduces strain, torsion, and synchrony in the left ventricle (LV).

METHODS: Ten 12-week-old C57BL/6 J mice were randomized to a high-fat or low-fat diet. After 5 months on …

Joint Effect Of Multiple Common Snps Predicts Melanoma Susceptibility, Shenying Fang, Jiali Han, Mingfeng Zhang, Li-E Wang, Qingyi Wei, Christopher I. Amos, Jeffrey E. Lee

Dartmouth Scholarship

Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional phenotypic model. We analyzed 11 SNPs that were associated with melanoma risk in previous studies and were genotyped in MD Anderson Cancer Center (MDACC) and Harvard Medical School investigations. Participants with ≥15 risk alleles were 5-fold more likely to have melanoma compared to those carrying ≤6. Compared to a model using the most significant single variant rs12913832, the increase in predictive …

Intramedullary Astrocytoma Presenting As Cervical And Upper Back Pain: A Casereport, Chao-Pin Yang, Chun-Yuan Cheng, Ying-Hsuan Li

Rehabilitation Practice and Science

Intramedullary astrocytomas are rare, accounting for 3% of all central nervous system astrocytomas. Pain is the most common clinical symptom, although symptoms can vary. These tumors typically progress over a period of months to years before the diagnosis is established. An intramedullary astrocytoma and cervical intervertebral disc herniation may coexist; the early symptoms maybe similar and an intramedullary astrocytoma might go undetected and be misdiagnosed as cervical disc herniation. This paper reports a 30-year-old male who presented with cervical and upper back pain extending to the right upper limb. Initially, the diagnosis was a cervical radiculopathy. After rehabilitation, for two …

Effects Of Exercise Training On Cardiorespiratory Fitness And Cardiac Function Among Heart Failure Patients With Decreased Left Ventricular Function: A Pilot Study, Chia-Huei Lin, Bing-Hsiean Tzeng, Li-Chi Chiang, Wen-Chii Tzeng, Liang-Cheng Chen, Shang-Lin Chiang

Rehabilitation Practice and Science

Background: Exercise is not only beneficial for physical and psychological health but can also improve cardiac contractility; thus, exercise can result in the improvement of the functional status of patients who suffer from irreversible damage from heart failure. However, there are limited local data on the effects of moderate-intensity exercise training on cardiorespiratory fitness and left ventricular function among patients with heart failure. Purpose: The aim of our study was to investigate the effects of moderate-intensity exercise training on cardiorespiratory fitness and left ventricular function among patients with heart failure. Methods: This is a pilot study with a single group …

Xenograft Tumors Vascularized With Murine Blood Vessels May Overestimate The Effect Of Anti-Tumor Drugs: A Pilot Study, Zhihong Dong, Atsushi Imai, Sudha Krishnamurthy, Zhaocheng Zhang, Benjamin David Zeitlin, Jacques E. Nör

All Dugoni School of Dentistry Faculty Articles

Recent evidence demonstrated that endothelial cells initiate signaling events that enhance tumor cell survival, proliferation, invasion, and tumor recurrence. Under this new paradigm for cellular crosstalk within the tumor microenvironment, the origin of endothelial cells and tumor cells may have a direct impact on the pathobiology of cancer. The purpose of this pilot study was to evaluate the effect of endothelial cell species (i.e. murine or human) on xenograft tumor growth and response to therapy. Tumor xenografts vascularized either with human or with murine microvascular endothelial cells were engineered, side-by-side, subcutaneously in the dorsum of immunodefficient mice. When tumors reached …

The Effects Of Hyaluronic Acid And Glucosamine On The Migration And Proliferation Of Tenocytes, Chien-Hung Chen, Jin-Fu Huang, Li-Lun Chen, Wen-Chung Tsai, Jong-Hwei S. Pang, Yu-Hsin Liao, Tung-Yang Yu

Rehabilitation Practice and Science

Tendinopathy or tendon rupture is a common disease. Studies have showed that hyaluronic acid and glucosamine benefit the process of tendon repair. Tendon healing requires the migration of tenocytes to the repair site, followed by the proliferation and synthesis of the extracellular matrix. However, the effects of hyaluronic acid and glucosamine on tenocytes remain to be explored. Here, we treated tenocytes from rat Achilles tendons with hyaluronic acid or glucosamine. The ability of tenocytes to migrate and proliferate was assessed by transwell filter migration assay and MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide) assay, respectively. Results from transwell filter migration assays showed that …

Kneeling Leg Curl With Internal Rotation Training Improves Agility In Patients With Anterior-Posterior Laxity Of Knee, Chih-Kuan Wu, Shu-Chun Huang, Kuan-Chou Chen, Cheng-Hsiu Lai, Chia-Hua Kuo, Shih-Wei Chou

Rehabilitation Practice and Science

Objective: Whether strengthening exercises emphasizing on internal rotators of the knee are more effective in improving shuttle-run agility of the knees with anterior-posterior laxity (AP laxity). Methods: Twenty men with AP laxity of knee were randomly assigned to the three experimental groups in different strengthening modes: plate-loaded squat press (SP), plate-loaded kneeling leg curl with internal rotation (KLCIR), and kneeling leg curl (KLC). Control group with stable knees received no training. Anterior-posterior laxity, shuttle-run agility, and isokinetic strength were evaluated before and after training. Results: Those with AP laxity of knee have poorer performance in the shuttle run test than …

Sensory Integration Dysfunction Affects Effectiveness Of Speech Therapy On Children With Functional Articulation Disorders, Li-Chen Tung, Ching-I Hu, Chin-Kai Lin, Ching-Lin Hsieh, Daniel Chiung-Jui Su, Ching-Chi Chen

Rehabilitation Practice and Science

Purpose: To compare the efficacy of speech therapy on children with functional articulation disorder with and without sensory integration dysfunction. Method: 20 young children were divided into two groups, those without sensory integration dysfunction (normal group, 10 children) and those with it (abnormal group, 10 children). The Mandarin Consonant Articulation Test for Preschool Children was administered on the children before and after therapy for articulation function. The oral motor function was evaluated by the Riley Motor Problems Inventory Oral Motor Tasks. Total of treatment sessions was recorded after the therapy. Results: Differences between the two groups in terms of age, …

The Effect Of Health Promotion With Physical Therapy And Intra-Articular Hyaluronic Acid For Knee Osteoarthritis, Chen-Liang Chou, Wen-Hsu Sung, Fu-Wei Liu, Hsuci-Chen Lee, Li-Lung Haung, Jin-Jong Chen

Rehabilitation Practice and Science

Purpose: Knee osteoarthritis (knee OA) is a common chronic disease that affects elderly. Intra-articular injection of hyaluronic acid (IAHA) and physical therapy for knee OA have been shown to have clinical benefits in randomized, clinical trials separately. However, it is generally accepted that optimal management of knee OA requires a combination of pharmacologic and nonpharmacologic treatment. Currently, few studies have directly evaluated the benefits of combining the 2 treatments for knee OA. The purpose of this study explored the efficacy of interventions in patients with knee osteoarthritis through combined IAHA and physical therapy. This study investigated the potential benefit of …