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Full-Text Articles in Medicine and Health Sciences

Effectiveness And Safety Of Oral Anticoagulants In Non-Valvular Atrial Fibrillation Patients With Prior Bleeding Events: A Retrospective Analysis Of Administrative Claims Databases, G. Y. H. Lip, Allison V. Keshishian, Amiee Kang, Xuemei Luo, Nipun Atreja, Yan Zhang, Patricia Schuler, Jenny Jiang, Huseyin Yuce, Steve Deitelzweig May 2022

Effectiveness And Safety Of Oral Anticoagulants In Non-Valvular Atrial Fibrillation Patients With Prior Bleeding Events: A Retrospective Analysis Of Administrative Claims Databases, G. Y. H. Lip, Allison V. Keshishian, Amiee Kang, Xuemei Luo, Nipun Atreja, Yan Zhang, Patricia Schuler, Jenny Jiang, Huseyin Yuce, Steve Deitelzweig

Publications and Research

Introduction

There are a paucity of real-world data examining effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin in nonvalvular atrial fibrillation (NVAF) patients with prior bleeding.

Methods

This retrospective analysis included data from 5 insurance claims databases and included NVAF patients prescribed OACs with prior bleeding. One-to-one propensity score matching was conducted between NOACs and warfarin and between NOACs in each database. Cox proportional hazards models were used to evaluate the risk of stroke/systemic embolism (SE) and MB.

Results

A total of 244,563 patients (mean age 77; 50% female) with prior bleeding included 55 ...


Covid-19 Vaccine Mandate, Mikhail Kun, Tatiana Ryzhakova May 2022

Covid-19 Vaccine Mandate, Mikhail Kun, Tatiana Ryzhakova

Publications and Research

The COVID-19 pandemic has wreaked havoc on the planet and killed millions of people. Health care workers and radiology technicians who come into direct contact with COVID-19 patients have indeed been the most affected by the virus. Since the pandemic began, the COVID-19 cases among health care workers have surged and quadrupled. COVID-19 vaccine mandate is the need of the time. Mandates have a history and are in effect for other diseases such as smallpox, measles, or mumps. But since the vaccines have come out for COVID-19, there is a public impetus to condemn these vaccines, based on the false ...


Open Lab Vs. Radiologic Students Final Practical Grades, Navdeep Kaur, Safraz Harun, Katie Tam, Robert O'Brien May 2022

Open Lab Vs. Radiologic Students Final Practical Grades, Navdeep Kaur, Safraz Harun, Katie Tam, Robert O'Brien

Publications and Research

Open Lab provides the students of the Radiologic Technology & Medical Imaging Department the opportunity outside regular class time to practice communicating effectively in a health care setting, and grants the students the freedom to craft critical thinking skills in a radiologic environment. Our research aims to analyze the correlation between hourly time spent in Open Lab, and its contributing factor to a student's overall Radiographic Procedures grade. The amount of time spent in Open Lab can additionally contribute to a student's grasp of didactic concepts, and their integration into the clinical setting. Additional time spent in the laboratory ...


Depression Is Associated With Myocardial Infarction Within A Two-Year Period Among Adults In China, Lydia W. Li, Greta Cheng, Hongwei Xu, Zhenmei Zhang, Jinyu Liu, Yeates Conwell Apr 2022

Depression Is Associated With Myocardial Infarction Within A Two-Year Period Among Adults In China, Lydia W. Li, Greta Cheng, Hongwei Xu, Zhenmei Zhang, Jinyu Liu, Yeates Conwell

Publications and Research

We examined whether baseline depression is associated with MI within a two-year period among adults aged 45+ in China and whether the association varies by sociodemographic characteristics. Two-year longitudinal data from a nationally representative sample of people aged 45+ in China were analyzed (N = 15,226). MI within the 2-year period was coded dichotomously. Baseline depression, assessed by the 10-item Center for Epidemiological Studies Depression scale, was used as a dichotomous and a continuous variable. After adjusting for medical conditions, lifestyle and sociodemographic characteristics, the odds of having an MI within the 2-year period were 46% greater for respondents with ...


Promoting Healthy Eating In Latin American Restaurants: A Qualitative Survey Of Views Held By Owners And Staff, Fuster, Melissa, Rosa Abreu, Margaret A. Handley, Donald Rose, Michelle A. Rodriguez, Emily G. Dimond, Brian Elbel, Terry T. K. Huang Apr 2022

Promoting Healthy Eating In Latin American Restaurants: A Qualitative Survey Of Views Held By Owners And Staff, Fuster, Melissa, Rosa Abreu, Margaret A. Handley, Donald Rose, Michelle A. Rodriguez, Emily G. Dimond, Brian Elbel, Terry T. K. Huang

Publications and Research

Background

Restaurants, particularly independently-owned ones that serve immigrant communities, are important community institutions in the promotion of dietary health. Yet, these restaurants remain under-researched, preventing meaningful collaborations with the public health sector for healthier community food environments. This research aimed to examine levels of acceptability of healthy eating promotion strategies (HEPS) in independently-owned Latin American restaurants (LARs) and identify resource needs for implementing HEPS in LARs.

Methods

We completed semi-structured, online discussions with LAR owners and staff (n = 20), predominantly from New York City (NYC), to examine current engagement, acceptability, potential barriers, and resource needs for the implementation of HEPS ...


Feasibility Of Using Electronic Health Records For Cascade Monitoring And Cost Estimates In Implementation Science Studies In The Adolescent Trials Network For Hiv/Aids Interventions, Tyra Dark, Kit N. Simpson, Sitaji Gurung, Amy L. Pennar, Marshall Chew, Sylvie Naar Apr 2022

Feasibility Of Using Electronic Health Records For Cascade Monitoring And Cost Estimates In Implementation Science Studies In The Adolescent Trials Network For Hiv/Aids Interventions, Tyra Dark, Kit N. Simpson, Sitaji Gurung, Amy L. Pennar, Marshall Chew, Sylvie Naar

Publications and Research

Background:One of the most difficult areas in the fight against HIV/AIDS is reaching out to youth aged 13 to 24 years. The proportion of youth living with HIV/AIDS on antiretroviral therapy (ART) and who are virally undetectable is low, highlighting significant challenges for reaching the Joint United Nations Program on HIV targets.

Objective:This study aimed to assess the feasibility of obtaining key clinical indicators and monitoring treatment, viral suppression, and retention components of the youth HIV treatment cascade in Adolescent Trials Network for HIV/AIDS Interventions clinics using electronic health record (EHR) downloads and to provide ...


Occupational Depression In A Spanish-Speaking Sample: Associations With Cognitive Performance And Work-Life Characteristics, Bianchi Renzo, Guadalupe Manzano García, Maria Pilar Montanes, Emily A. Schonfeld, Irvin Sam Schonfeld Apr 2022

Occupational Depression In A Spanish-Speaking Sample: Associations With Cognitive Performance And Work-Life Characteristics, Bianchi Renzo, Guadalupe Manzano García, Maria Pilar Montanes, Emily A. Schonfeld, Irvin Sam Schonfeld

Publications and Research

This 386-participant study investigated the structural and psychometric properties of the Spanish version of the Occupational Depression Inventory (ODI). Exploratory structural equation modeling bifactor analysis revealed that the ODI meets the requirements for essential unidimensionality. Measurement invariance held across our sample and the English- and French-speaking samples used in the ODI’s initial validation study. Mokken scale analysis indicated that (a) the scalability of the instrument was strong, (b) no violations of monotonicity or local independence were present, and (c) invariant item ordering was sufficiently accurate. The ODI’s reliability was optimal. The ODI exhibited both convergent validity and discriminant ...


An Evaluation Of The Effect Of The Oxycontin® Reformulation On Unintentional Fatal And Non-Fatal Overdose, Daniel C. Beachler, Kelsey Hall, Renu Garg, Geetanjoli Banerjee, Ling Li, Luke Boulanger, Huseyin Yuce, Alexander M. Walker Mar 2022

An Evaluation Of The Effect Of The Oxycontin® Reformulation On Unintentional Fatal And Non-Fatal Overdose, Daniel C. Beachler, Kelsey Hall, Renu Garg, Geetanjoli Banerjee, Ling Li, Luke Boulanger, Huseyin Yuce, Alexander M. Walker

Publications and Research

Objectives: OxyContin® was reformulated with a polyethylene oxide matrix in August 2010 to reduce the potential for intravenous abuse and for abuse by insufflation. The objective of this study was to evaluate the impact of OxyContin’s reformulation on overdose risk for individuals dispensed OxyContin in comparison to those dispensed other opioids under regular care. Methods: Three national insurance databases with National Death Index linkage identified OD in individuals with any dispensing of OxyContin or a primary comparator opioid (ER morphine, transdermal fentanyl, or methadone) between July 2008 through September 2015. A difference-in-differences design was used to compare the pre-post ...


Diagnosis Of Polypoidal Choroidal Vasculopathy From Fluorescein Angiography Using Deep Learning, Yu-Yeh Tsai, Wei-Yang Ling, Shih-Jen Chen, Paisan Ruamviboonsuk, Cheng-Ho King, Chia-Ling Tsai Feb 2022

Diagnosis Of Polypoidal Choroidal Vasculopathy From Fluorescein Angiography Using Deep Learning, Yu-Yeh Tsai, Wei-Yang Ling, Shih-Jen Chen, Paisan Ruamviboonsuk, Cheng-Ho King, Chia-Ling Tsai

Publications and Research

Purpose: To differentiate polypoidal choroidal vasculopathy (PCV) from choroidal neovascularization (CNV) and to determine the extent of PCV from fluorescein angiography (FA) using attention-based deep learning networks.

Methods: We build two deep learning networks for diagnosis of PCV using FA, one for detection and one for segmentation. Attention-gated convolutional neural network (AG-CNN) differentiates PCV from other types of wet age-related macular degeneration. Gradient-weighted class activation map (Grad-CAM) is generated to highlight important regions in the image for making the prediction, which offers explainability of the network. Attention-gated recurrent neural network (AG-PCVNet) for spatiotemporal prediction is applied for segmentation of PCV ...


From Abortion Rights To Reproductive Justice: A Call To Action, Erica Goldblatt Hyatt, Judith L.M. Mccoyd, Mery Diaz Feb 2022

From Abortion Rights To Reproductive Justice: A Call To Action, Erica Goldblatt Hyatt, Judith L.M. Mccoyd, Mery Diaz

Publications and Research

As aggressive cultural and legislative attacks on abortion rights and access continue, we call upon social workers to pursue the liberatory aims of the reproductive justice (RJ) movement. We argue that the RJ framework, rooted in feminist theory, aligns with social work’s social justice ethos and goals, appropriately guiding advocacy and intervention. After outlining the central aims and tenets of the RJ movement, we consider policies that impair RJ and those that could promote RJ, focusing on enhancing body sovereignty, childbearing, and parenting. We conclude with concrete recommendations for how social workers can pursue RJ professionally and personally.


Maintain The Sharp Cutting Edge Of Periodontal Instruments, Khrystyna Vyprynyuk, Annie Chitlall Feb 2022

Maintain The Sharp Cutting Edge Of Periodontal Instruments, Khrystyna Vyprynyuk, Annie Chitlall

Publications and Research

No abstract provided.


Metric-Driven Initiative For Promoting Staff Diversity, Dewi Brown-Deveaux, Brittany R. Richards Jan 2022

Metric-Driven Initiative For Promoting Staff Diversity, Dewi Brown-Deveaux, Brittany R. Richards

Publications and Research

No abstract provided.


Results Of A Phase 1, Randomized, Placebocontrolled First-In-Human Trial Of Griffithsin Formulated In A Carrageenan Vaginal Gel, Natalia Teleshova, Maria J. Keller, José A. Fernández Romero, Barbara A. Friedland, George W. Creasy, Marlena G. Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U. Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R. O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N. Fichorova, Tamara Kalir, Thomas M. Zydowsky Jan 2022

Results Of A Phase 1, Randomized, Placebocontrolled First-In-Human Trial Of Griffithsin Formulated In A Carrageenan Vaginal Gel, Natalia Teleshova, Maria J. Keller, José A. Fernández Romero, Barbara A. Friedland, George W. Creasy, Marlena G. Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U. Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R. O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N. Fichorova, Tamara Kalir, Thomas M. Zydowsky

Publications and Research

HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT’s preclinical safety, lack of systemic absorption after vaginal administration in animal studies, and lack of cross-resistance with existing ARV drugs prompted its development for topical HIV PrEP. We investigated safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of PC-6500 (0.1% GRFT in a carrageenan (CG) gel) in healthy women after vaginal administration. This randomized, placebo-controlled, parallel group, double-blind first-in-human phase 1 study enrolled healthy, HIV-negative, non-pregnant women aged 24–45 years. In the open label period ...


The Imaginal Lexicon Of Aging Studies, William Ebenstein Jan 2022

The Imaginal Lexicon Of Aging Studies, William Ebenstein

Publications and Research

Aging Studies focuses on the cultural, humanistic and experiential aspects of aging insofar as these are already embedded in literature, art, language and everyday life. The lexicon of this multi-disciplinary field has evolved in response to shifts in cultural attitudes, social roles, and conceptual frameworks. At the same time, many age-related words have links to poetic imagery and ancient myths, and to evocative etymologies that conjure an historical context. The article looks at the ongoing and surprisingly difficult effort to find the right word to call an older person. It reviews the language and literary genres associated with longevity. And ...


Understanding Covid-19 Among People Of Dominican Descent In The U.S.: A Comparison Of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island And Connecticut, Ramona Hernandez, Pedro Ortega, Nancy Sohler, Sarah Marrara Jan 2022

Understanding Covid-19 Among People Of Dominican Descent In The U.S.: A Comparison Of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island And Connecticut, Ramona Hernandez, Pedro Ortega, Nancy Sohler, Sarah Marrara

Publications and Research

The present study “Understanding COVID-19 Among People of Dominican Descent in the U.S.: A Comparison of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island and Connecticut” is the first research study to examine the experience of people of Dominican origins residing in the United States (U.S.) amidst the pandemic caused by the SARS-CoV-2 virus. The current study is based on a probabilistic and representative sample of Dominicans across the seven states in which the majority—85%—of Dominicans living in the U.S. reside. The Dominican Studies Institute (CUNY-DSI) at City College and the School of Medicine ...


Righting Health Policy: Bioethics, Political Philosophy, And The Normative Justification Of Health Law And Policy, D. Robert Macdougall Jan 2022

Righting Health Policy: Bioethics, Political Philosophy, And The Normative Justification Of Health Law And Policy, D. Robert Macdougall

Publications and Research

In Righting Health Policy, D. Robert MacDougall argues that bioethics needs but does not have adequate tools for justifying law and policy. Bioethics’ tools are mostly theories about what we owe each other. But justifying laws and policies requires more; at a minimum, it requires tools for explaining the legitimacy of actions intended to control or influence others. It consequently requires political, rather than moral, philosophy. After showing how bioethicists have consistently failed to use tools suitable for achieving their political aims, MacDougall develops an interpretation of Kant’s political philosophy. On this account the legitimacy of health laws does ...


From Burnout To Occupational Depression: Recent Developments In Research On Job-Related Distress And Occupational Health, Irvin Sam Schonfeld, Renzo Bianchi Dec 2021

From Burnout To Occupational Depression: Recent Developments In Research On Job-Related Distress And Occupational Health, Irvin Sam Schonfeld, Renzo Bianchi

Publications and Research

Job-related distress has been a focal concern in occupational health science. Job-related distress has a well-documented health-damaging and life-threatening character, not to mention its economic cost. In this article, we review recent developments in research on job-related distress and examine ongoing changes in how job-related distress is conceptualized and assessed. By adopting an approach that is theoretically, empirically, and clinically informed, we demonstrate how the construct of burnout and its measures, long favored in research on job-related distress, have proved to be problematic. We underline a new recommendation for addressing job-related distress within the long-established framework of depression research. In ...


Comparative Analysis Of 3d Printed Denture Resins With Traditional Denture Materials At The Micro Level, Aneeza Hussain, Caleb Beckwith, Gaffar Gailani Dec 2021

Comparative Analysis Of 3d Printed Denture Resins With Traditional Denture Materials At The Micro Level, Aneeza Hussain, Caleb Beckwith, Gaffar Gailani

Publications and Research

The aim of this experiment was to evaluate and identify compression strength between traditionally manufactured acrylic dentures and additive manufacturing resin dentures. Specifically, the dentures produced by Uhler Dental, its Reveal line were compared against samples produced on the Formlabs Form 2 SLA, Stereolithography, 3D printer using their Denture Teeth A2 resin to test compression strength to assure they are compatible with the occlusal forces in the oral cavity. Using the ZwickRoell tensile testing machine, it appeared that the acrylic dentures were half as strong as the resin dentures. Then we went ahead to and did a comparative analysis under ...


Expanding The Conceptualization Of Support In Low-Wage Carework: The Case Of Home Care Aides And Client Death, Emma K. Tsui, Marita Lamonica, Maryam Hyder, Paul Landsbergis, Jennifer Zelnick, Sherry Baron Dec 2021

Expanding The Conceptualization Of Support In Low-Wage Carework: The Case Of Home Care Aides And Client Death, Emma K. Tsui, Marita Lamonica, Maryam Hyder, Paul Landsbergis, Jennifer Zelnick, Sherry Baron

Publications and Research

Home care aides are a rapidly growing, non-standard workforce who face numerous health risks and stressors on the job. While research shows that aides receive limited support from their agency employers, few studies have explored the wider range of support that aides use when navigating work stress and considered the implications of these arrangements. To investigate this question, we conducted 47 in-depth interviews with 29 home care aides in New York City, focused specifically on aides’ use of support after client death. Theories of work stress, the social ecological framework, and feminist theories of care informed our research. Our analysis ...


A Closer Look At The Aha's Antibiotic Prophylaxis Guidelines, Dora-Ann Oddo Dec 2021

A Closer Look At The Aha's Antibiotic Prophylaxis Guidelines, Dora-Ann Oddo

Publications and Research

In May 2021, the American Heart Association (AHA) updated its antibiotic prophylaxis guidelines for the prevention of infective endocarditis (IE). As some dental and dental hygiene procedures may increase the risk of this potentially life-threatening infection in at-risk patients, oral health professionals must have a thorough understanding of this serious, albeit rare infection of the heart and understand appropriate precautions for treatment. This article focuses on the AHA's guidelines; however, oral health professionals should also consider the IE guidelines from the American Academy of Orthopedics Surgeons.


The Nature Of Anti-Asian American Xenophobia During The Coronavirus Pandemic: A Preliminary Exploration Into Envy As A Key Motivator Of Hate, Daisuke Akiba Nov 2021

The Nature Of Anti-Asian American Xenophobia During The Coronavirus Pandemic: A Preliminary Exploration Into Envy As A Key Motivator Of Hate, Daisuke Akiba

Publications and Research

Background. The current Coronavirus pandemic has been linked to a dramatic increase in anti-Asian American and Pacific Islander (AAPI) hate incidents in the United States. At the time of writing, there does not appear to be any published empirical research examining the mechanisms underlying Asiaphobia during the current pandemic. Based on the stereotype content model, we investigated the idea that ambivalent attitudes toward AAPIs, marked primarily with envy, may be contributing to anti-AAPI xenophobia. Methods. Study 1 (N = 140) explored, through a survey, the link between envious stereotypes toward AAPIs and Asiaphobia. Study 2 (N = 167), utilizing autobiographical recall tasks ...


Insights Into Using Plants In Management Of Viral Diseases., Vyacheslav Dushenkov, Anna Dushenkov Nov 2021

Insights Into Using Plants In Management Of Viral Diseases., Vyacheslav Dushenkov, Anna Dushenkov

Publications and Research

Botanical therapeutics possess a unique potential in the treatment of viral diseases. The pharmacological base and clinical use of botanical therapeutics have been extensively reviewed. The mode of action(s) may be built either on the direct interference with the virus's ability to enter human cells, virus replication, or exerting immune-modulatory and anti-inflammatory effects. The adjuvant treatment with botanical therapeutics has the potential to result in advances in symptom resolution, decrease in disease burden and shortening its duration.


Treatment Selection Using Prototyping In Latent-Space With Application To Depression Treatment, Akiva Kleinerman, Ariel Rosenfeld, David Benrimoh, Robert Fratila, Caitrin Armstrong, Joseph Mehltretter, Eliyahu Shneider, Amit Yaniv-Rosenfeld, Jordan Karp, Charles F. Reynolds, Gustavo Turecki, Adam Kapelner Nov 2021

Treatment Selection Using Prototyping In Latent-Space With Application To Depression Treatment, Akiva Kleinerman, Ariel Rosenfeld, David Benrimoh, Robert Fratila, Caitrin Armstrong, Joseph Mehltretter, Eliyahu Shneider, Amit Yaniv-Rosenfeld, Jordan Karp, Charles F. Reynolds, Gustavo Turecki, Adam Kapelner

Publications and Research

Machine-assisted treatment selection commonly follows one of two paradigms: a fully personalized paradigm which ignores any possible clustering of patients; or a sub-grouping paradigm which ignores personal differences within the identified groups. While both paradigms have shown promising results, each of them suffers from important limitations. In this article, we propose a novel deep learning-based treatment selection approach that is shown to strike a balance between the two paradigms using latent-space prototyping. Our approach is specifically tailored for domains in which effective prototypes and sub-groups of patients are assumed to exist, but groupings relevant to the training objective are not ...


Impact Of Forensic Medical Evaluations On Immigration Relief Grant Rates And Correlates Of Outcomes In The United States., Holly G. Atkinson, Katarzyna Wyka, Kathryn Hampton, Christian Seno, Elizabeth Yim, Deborah Ottenheimer, Nermeen Arastu Nov 2021

Impact Of Forensic Medical Evaluations On Immigration Relief Grant Rates And Correlates Of Outcomes In The United States., Holly G. Atkinson, Katarzyna Wyka, Kathryn Hampton, Christian Seno, Elizabeth Yim, Deborah Ottenheimer, Nermeen Arastu

Publications and Research

The purpose of this study was to investigate the impact of forensic medical evaluations on grant rates for applicants seeking immigration relief in the United States (U.S.) and to identify significant correlates of grant success. We conducted a retrospective analysis of 2584 cases initiated by Physicians for Human Rights between 2008-2018 that included forensic medical evaluations, and found that 81.6% of applicants for various forms of immigration relief were granted relief, as compared to the national asylum grant rate of 42.4%. Among the study’s cohort, the majority (73.7%) of positive outcomes were grants of asylum ...


Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente Nov 2021

Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente

Publications and Research

Alzheimer’s Disease (AD), the most common type of dementia, is a neurodegenerative disease characterized by plaques of amyloid-beta (Aβ) peptides found in the cerebral cortex of the brain. The pathological mechanism by which Aβ aggregation leads to neurodegeneration remains unknown. Interestingly, genetic mutations do not explain most AD cases suggesting that other mechanisms are at play. Epigenetic mechanisms, such as histone post-translational modifications (PTMs), may provide insight into the development of AD. Here, we exploit a yeast Aβ overexpression model to map out the histone PTM landscape associated with AD. We find a modest decrease in the acetylation levels ...


An Innovative Approach For Integrating Mandatory, Longitudinal Spirituality Training Into The Medical School Curriculum, David W. Fleenor, Holly G. Atkinson, Reena Karani, Susan Lerner, Staci Leisman, Deborah Marin Nov 2021

An Innovative Approach For Integrating Mandatory, Longitudinal Spirituality Training Into The Medical School Curriculum, David W. Fleenor, Holly G. Atkinson, Reena Karani, Susan Lerner, Staci Leisman, Deborah Marin

Publications and Research

Problem:

Most Americans indicate they are religious and/or spiritual and wish to have their beliefs taken into account when engaging with health care providers, yet gaps in medical education and health care practice remain. To underscore the importance of spirituality as a significant social determinant of health, a team at the Icahn School of Medicine at Mount Sinai in New York developed mandatory spirituality and health training for students integrated into all 4 years of the undergraduate medical education curriculum.

Approach:

From 2014 to 2020, a small group of faculty took an innovative approach, launching the initiative and expanding ...


Racial And Ethnic Data Reported For Peanut Allergy Epidemiology Do Little To Advance Its Cause, Treatment, Or Prevention, Nigel Mark Thomas Oct 2021

Racial And Ethnic Data Reported For Peanut Allergy Epidemiology Do Little To Advance Its Cause, Treatment, Or Prevention, Nigel Mark Thomas

Publications and Research

No abstract provided.


Electrocardiographic Changes In Emphysema, Puneet Gupta, Hitangee Jain, Misbah Gill, Gurpreet Bharaj, Nauman Khalid, Waseem Chaudhry, Lovely Chhabra Oct 2021

Electrocardiographic Changes In Emphysema, Puneet Gupta, Hitangee Jain, Misbah Gill, Gurpreet Bharaj, Nauman Khalid, Waseem Chaudhry, Lovely Chhabra

Publications and Research

Chronic obstructive lung disease (COPD), predominantly emphysema, causes several thoracic anatomical and hemodynamic changes which may cause changes in various electrocardiographic parameters. A 12-lead electrocardiogram (ECG), which is often a part of routine evaluation in most clinical settings, may serve as a useful screening modality for diagnosis of COPD or emphysema. Our current article aims to provide a comprehensive review of the electrocardiographic changes encountered in COPD/emphysema utilizing published PubMed and Medline literature database. Several important ECG changes are present in COPD/emphysema and may serve as a good diagnostic tool. Verticalization of Pvector, changes in QRS duration, pattern ...


A Systematic Review Of Diet Quality Index And Obesity Among Chinese Adults, Isma'il Kadam, Sudeep Neupane, Jingkai Wei, Lee Ann Fullington, Tricia Li, Ruopeng An, Li Zhao, Amy Ellithorpe, Xinyin Jiang, Liang Wang Oct 2021

A Systematic Review Of Diet Quality Index And Obesity Among Chinese Adults, Isma'il Kadam, Sudeep Neupane, Jingkai Wei, Lee Ann Fullington, Tricia Li, Ruopeng An, Li Zhao, Amy Ellithorpe, Xinyin Jiang, Liang Wang

Publications and Research

Diet quality scores are designed mainly based on Western-style dietary patterns. They were demonstrated to be good indicators of obesity in developed but not developing countries. Several diet quality scores were developed based on the Chinese dietary guidelines, yet no systematic review exists regarding how they were related to obesity. We searched research articles published between 2000 and 2021 in PubMed, CINAHL, and Scopus databases. Both cross-sectional and prospective studies that examined the relationship between a diet quality score and weight, body mass index, obesity, or waist circumference conducted in a Chinese population were selected. From the 602 articles searched ...


Who Needs To Be “Burned-Out”? Time For A New Approach To Job-Related Distress, Renzo Bianchi, Irvin Sam Schonfeld Oct 2021

Who Needs To Be “Burned-Out”? Time For A New Approach To Job-Related Distress, Renzo Bianchi, Irvin Sam Schonfeld

Publications and Research

Burnout is a popular indicator of job-related distress, notably in research on the ill-being of medical professionals. The burnout construct is, however, plagued by definitional and measurement problems. Often unnoticed, these problems undermine findings and conclusions emanating from burnout research. The definitional and measurement problems affecting the burnout construct hamper knowledge growth, waste resources, and impede our ability to make informed decisions and take effective action to support personnel. It is time for occupational health specialists to abandon the idea of burnout and focus on occupational depression.