Medicine and Health Sciences Commons^™

Chinese Immigrants With Non-Insulin-Dependent Diabetes Mellitus: Nutritional Self-Management Approach, Winnie Manlai Wong

Student Theses, Dissertations and Capstones

Background: Chinese immigrants (CIs) with non-insulin dependent diabetes mellitus (NIDDM) generally have poor control in their diet regimen. Due to the variation in body mass, physiology, and cultural differences as compare with the general American population, special attention must be conducted in treating diabetes in Cis, emphasizing culturally sensitive care and nutrition therapy that acknowledge the differences. Purpose: The purpose of this project was to assess cultural challenges in self-management for CIs living with non-insulin dependent diabetes mellitus and evaluate the effectiveness of a diabetic nutritional self-management guide tailored to this population. Theoretical Framework: Havelock’s theory of change is a …

Undergraduate Bulletin, 2019-2020, Minnesota State University Moorhead

Undergraduate Bulletins (Catalogs)

No abstract provided.

Cortical Stimulation Mapping Of Heschl’S Gyrus In The Auditory Cortex For Tinnitus Treatment, Austin Huang

CMC Senior Theses

Tinnitus is the perception of sound in the absence of an actual sound stimulus. Recent developments have shifted the focus to the central nervous system and the neural correlate of tinnitus. Broadly, tinnitus involves cortical map rearrangement, pathological neural synchrony, and increased spontaneous firing rates. Various cortical regions, such as Heschl’s gyrus in the auditory cortex, have been found to be associated with different aspects of tinnitus, such as perception and loudness. I propose a cortical stimulation mapping study of Heschl’s gyrus using a depth and subdural electrode montage to conduct electrocorticography. This study would provide high-resolution data on abnormal …

Part 2: Preparing Entry-Level Occupational And Physical Therapy Students To Promote Healthy Lifestyles Emphasizing Healthy Eating With Individuals With Disabilities, Brooks C. Wingo, Donald H. Lein, Beth A. Barstow, Christopher A. Eidson, Tara S. Pearce, Laurie A. Malone, David M. Morris

Journal of Occupational Therapy Education

Rehabilitation professionals including occupational therapists (OT) and physical therapists (PT) are increasingly called upon to incorporate health promotion of lifestyle behaviors including physical activity and healthy eating into routine clinical care. While OTs and PTs may be comfortable promoting activity-related behaviors, many are less comfortable with nutrition behaviors. To address entry-level OT and PT students’ perceived discomfort with discussing diet-related behaviors, faculty developed a healthy eating module for students to use during a community-based service learning program. The purpose of this paper is to describe the formative evaluation process of developing the healthy eating module, and to discuss results of …

Cost Effectiveness Analysis Of Enzalutamide, Abiraterone Plus Prednisone And Cabazitaxel Plus Predinsone For The Treatment Of Visceral Metastatic Castration Resistant Prostate Cancer (Mcrpc) After Docetaxel Therapy, Yazan K. Barqawi

Pharmaceutical Sciences ETDs

Background: Prostate cancer is the second leading cause of death after lung cancer among men in the US. The America Cancer Society predicts 164,690 new cases and 29,430 prostate cancer deaths in 2018. Of those diagnosed with prostate cancer, about 10-20 % will develop castration-resistant prostate cancer (CRPC) within 5 years of diagnosis and 70 % of those cases will metastasize to mCRPC. In 2014, nearly US $13.4 billion was spent on prostate cancer in the US and expected to reach US $15.4 billion by 2020; making prostate cancer the fifth most costly cancer.

Objective: To conduct a cost-effective analysis …

Fwer Controlling Procedures In Simultaneous And Selective Inference, Li Yu

Dissertations

With increasing complexity of research objectives in clinical trials, a variety of relatively complex and less intuitive multiple testing procedures (MTPs) have been developed and applied in clinical data analysis. In order to make testing strategies more explicit and intuitive to communicate with non-statisticians, several flexible and powerful graphical approaches have recently been introduced in the literature for developing and visualizing newer MTPs. Nevertheless, some theoretical as well as methodological issues still remain to be fully addressed. This dissertation addresses several important issues arising in graphical approaches and related selective inference problems. It consists of three parts.

In the first …

Functionalized Carbon Nanotubes In Hydrophobic Drug Delivery, Kun Chen

Dissertations

The direct incorporation of carboxylated carbon nanotubes (f-CNTs) into hydrophobic drug particles during their formation via anti-solvent precipitation is presented. The approach is tested using two drugs namely antifungal agent Griseofulvin (GF) and antibiotic Sulfamethoxazole (SMZ) that have very different aqueous solubility. It is observed that the f-CNTs dispersed in the water serve as nucleating sites for crystallization and are readily incorporated into the drug particles without altering crystal structure or other properties. The results show that the hydrophilic f-CNTs dramatically enhance dissolution rate for both drugs. The increased degree of functionalization leads to higher hydrophilicity and therefore faster dissolution …

What's Happening: December 31, 2018, Maine Medical Center

What's Happening

No abstract provided.

Infection Of Plasmodium Knowlesi Malaria In Human, I Gede Yasa Asmara

Jurnal Penyakit Dalam Indonesia

Plasmodium knowlesi (P. knowlesi) has been recognised as the fifth of malaria infections in human after P. vivax, P. falciparum, P. malariae and P. ovale. Epidemiology and clinical features of the disease have much been discussed only in several literatures since the incidence increased in Kapit Division, Sarawak, Malaysia in 2004. A large-scale research investigating real incidence of the infection in South East Asia is important. Because of rapid life cycle, the number of parasite in the blood can increase significantly, result in potential severe malaria. Pathophysiology aspect of the disease has not been clear yet, particularly on how severe …

Correlation Between History Of Fall And Timed Up And Go Test In Geriatric, Mifta Nurmalasari, Novira Widajanti, Rwahita Satyawati Dharmanta

Jurnal Penyakit Dalam Indonesia

Introduction. Fall is the global major problem in geriatrics as it causes physical and physicological impairment, even leads to mortality. Timed up and go test (TUG) is the screening method which commonly used in medical practice as standard examination to assess mobility, balance, and fall risk.This study aimed to determine the correlation between TUG and history of falls in geriatric patients at General Hospital Dr. Soetomo Surabaya, Indonesia. Methods. A cross-sectional study was conducted among geriatric patients in Dr. Soetomo hospital with criteria ≥ 60 years old, mini mental state examination (MMSE) score ≥ 17, did not suffer from hemiplegic …

Relationship Between Neutrophil Lymphocyte Ratio And Lower Extremity Peripheral Artery Disease In Patients With Type 2 Diabetes Mellitus, Krishna Adi Wibisana, Imam Subekti, Dono Antono, Pringgodigdo Nugroho

Jurnal Penyakit Dalam Indonesia

Introduction. Lower extremity peripheral artery disease (PAD) is one of diabetic macrovascular complication which has high rate of morbidity and mortality. Chronic inflammation has been known to have a role in the pathogenesis of PAD in diabetic patient. Recently, neutrophil lymphocyte ratio (NLR) has been used as a marker of chronic inflammation. This study aimed to determine the relationship between neutrophil lymphocyte ratio and lower extremity peripheral artery disease in type 2 diabetic patient in Cipto Mangunkusumo hospital. Methods. A cross sectional study was conducted on 249 patients with type 2 diabetes mellitus who underwent ankle brachial index (ABI) examination …

Ruang Terbuka Olahraga Di Kecamatan Gunungpati, Kota Semarang: Kajian Analisis Melalui Sport Development Index, Dhimas Bagus Dharmawan, Rofa Ichsandi, Ricka Ulfatul Faza

Jurnal Keolahragaan

Tujuan penelitian ini adalah mengidentifikasi ruang terbuka olahraga di Kecamatan Gunungpati dalam memfasilitasi masyarakat berolahraga yang ditinjau dari Sport Development Index (SDI). Dalam penelitian ini metode yang digunakan adalah metode survei dengan pendekatan deskriptif kuantitatif yang ditinjau dari SDI. Instrumen penelitian yang digunakan adalah observasi dan wawancara, selanjutnya data yang diperoleh dianalisis secara kuantitatif dengan menggunakan analisis SDI dari dimensi ruang terbuka. Hasil penelitian ini adalah berupa data jumlah ruang terbuka olahraga yang ada di Kecamatan Gunungpati adalah 34 ruang terbuka olahraga dengan total luas 43.854,5 m2, sedangkan jumlah populasi penduduk yang ada adalah berjumlah 12.817 jiwa yang dijadikan sebagai …

Persepsi Mahasiswa Fakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta Terhadap Atribut Produk Minuman Kesehatan, Chairina Vidya, Fatma Zuhrotun Nisa, Ika Ratna Palupi

Jurnal Keolahragaan

Pemberian cairan sangat penting bagi atlet untuk menghindari dehidrasi yang dapat menyebabkan gangguan fisiologis tubuh. Produk minuman kesehatan diyakini mampu meningkatkan energi dan menjaga produktivitas pada saat dan setelah melakukan aktivitas fisik seperti bekerja dan olahraga, terutama bagi para olahragawan. Perilaku membeli produk minuman kesehatan dilakukan berdasarkan preferensi dan kebutuhan konsumen, salah satunya mempertimbangkan atribut produk. Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa Fakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta (FIK UNY) terhadap atribut produk minuman kesehatan (harga, kemasan, merek, label, dan rasa). Penelitian menggunakan desain observasional cross sectional dengan subjek penelitian 100 orang mahasiswa FIK UNY yang diambil secara purposif. …

Identifikasi Profil Antropometri Dan Pemenuhan Zat Gizi Atlet Difabel Tenis Meja Di Indonesia, Mirza Hapsari Sakti Titis Penggalih, Kurnia Maratus Solichah, Diana Pratiwi, Ibtidau Niamilah, Mustika Cahya Nirmala Dewinta, Almira Nadia, Marina Dyah Kusumawati, Christofer Siagian, Rora Asyulia

Jurnal Keolahragaan

Para-atlet dikenal juga dengan sebutan atlet yang menyandang disabilitas pada bagian tertentu. Pembagian cabang olahraga pada difabel atlet hampir sama dengan atlet umumnya, namun memiliki penyesuaian terhadap jenis cacat fisik yang dialami. Tujuan penelitian ini untuk mengetahui dan mengidentifikasi profil antropometri dan pemenuhan asupan zat gizi pada atlet difabel tenis meja. Metode yang digunakan pada studi ini adalah deskriptif kuantitatif. Populasi dalam penelitian ini yaitu atlet difabel tenis meja di bawah pengawasan Kementrian Pemuda dan Olahraga, Indonesia yang sedang melakukan training centre untuk persiapan Sea Games 2017. Sampel yang diikutkan dalam penelitian ini yaitu seluruh populasi atlet difabel tenis meja …

Diagnosing And Treating Diabetes In Rural Jamaica, Emily C. Sims

Scholarship in Medicine - All Papers

Objective: This research study was conducted to determine the correlation between finger stick glucose and finger stick hemoglobin A1c values in order to draw conclusions about the redundancy of the two tests in a rural Jamaican traveling clinic setting. Methods: This study was conducted using de-identified data from an electronic health record used in clinics in St. Mary’s Parish, Jamaica. A correlational analysis was completed using the glucose and A1c variables to determine both the direction and strength of the correlation. Results: A positive correlation of 0.654549 was found in analysis. This correlation did not meet the set threshold for …

An Acute Non-Traumatic Rib Fracture Detected By Ultrasound And A Reviewarticle Of The Literature, Tze Chao Wee, Chueh-Hung Wu, Tyng-Guey Wang

Rehabilitation Practice and Science

Ultrasound is increasingly used for the diagnosis of musculoskeletal conditions, particularly in soft tissue injuries. In some cases, it is useful for the evaluation of fractures. A 54-year-old woman presented with focal a non-traumatic right-sided chest pain. Physical examination revealed a focal area of tenderness on palpation. Erect chest X-ray was unremarkable. A focused musculoskeletal ultrasound was carried out to examine the area of tenderness and a rib fracture which was not detected on the erect chest X-ray was diagnosed during sonographic examination. A brief literature reviewarticle on the use of ultrasound in the diagnosis of fracture, in particular rib …

Acute Exacerbations Of Progressive-Fibrosing Interstitial Lung Diseases., Martin Kolb, Benjamin Bondue, Alberto Pesci, Yasunari Miyazaki, Jin Woo Song, Nitin Y. Bhatt, John T. Huggins, Justin M. Oldham, Maria L. Padilla, Jesse Roman, Md, Shane Shapera

Department of Medicine Faculty Papers

Acute exacerbation of interstitial lung disease (ILD) is associated with a poor prognosis and high mortality. Numerous studies have documented acute exacerbation in idiopathic pulmonary fibrosis (IPF), but less is known about these events in other ILDs that may present a progressive-fibrosing phenotype. We propose defining acute exacerbation as an acute, clinically significant respiratory deterioration, typically less than 1 month in duration, together with computerised tomography imaging showing new bilateral glass opacity and/or consolidation superimposed on a background pattern consistent with fibrosing ILDs. Drawing on observations in IPF, it is suspected that epithelial injury or proliferation and autoimmunity are risk …

The Comprehensive Cancer Control National Partnership Celebrates The 20th Anniversary Of The National Comprehensive Cancer Control Program, National Chair

Michigan Journal of Public Health

No abstract provided.

The Preliminary Results Of Extracorporeal Shockwave Therapy In Patients With Piriformis Syndrome, Ching-Fen Huang, Tien-Wen Chen, Cyuan-Fong Li, Yu-Hsuan Hsiao, Chia-Hsin Chen, Mao-Hsiung Huang

Rehabilitation Practice and Science

The study was designed to evaluate the therapeutic effect of extracorporeal shockwave therapy (ESWT) on the rehabilitation of patients with piriformis syndrome. Thirty-six patients diagnosed with unilateral piriformis syndrome were included and allocated randomly into three groups, Groups A-C, with twelve patients in each group. Patients in Groups A-C all received conventional physical modalities programs, including hot packs and interferential current therapy, three times weekly for six weeks. Patients in Group B received an extra twenty minutes of stretching exercise therapy after physical modalities therapy, and Group C received the same therapy as in Group B and extra shockwave therapy …

Effects Of Lidocaine On Migration, Proliferation, Collagen Expression And Cytotoxicity Of Tendon Cells, Hsiang-Ning Chang, Jong-Hwei S Pang, Miao-Sui Lin, Wen-Chung Tsai

Rehabilitation Practice and Science

Background: Lidocaine is commonly used for the treatment of a variety of tendinopathies in combination with corticosteroids injection. Purpose: The goal of this study was to evaluate the effect of lidocaine on migration, proliferation, protein expressions of type I and III collagen and cytotoxicity of tendon cells. Methods: Rat Achilles tendon cells were divided into control and study groups (treated with 0.1%, 0.15%, and 0.2% lidocaine). Tendon cell migration and proliferation were assessed using transwell filter migration assay and MTT assay, respectively. Cytotoxicity of lidocaine was evaluated by the LDH-Cytotoxicity assay. The protein expression of type I and type III …

Domain Rearrangement And Denaturation In Ebola Virus Protein Vp40, Rudramani Pokhrel, Pornthep Sompornpisut, Prem Chapagain, Brian Olson, Bernard Gertsman, Ras B. Pandey

Faculty Publications

The VP40 protein plays a critical role in coordinating the virion assembly, budding, and replication of the Ebola virus. Efforts have been made in recent years to understand various aspects of VP40 structure, dynamics, and function such as assembly of the protein and its roles in virus replication and penetration of the protein into the plasma membrane. A major conformational transformation is necessary for VP40 to form some of its oligomeric structures and to perform various functions. This conformational change from a compact structure with the N-terminal domain (NTD) and C-terminal domain (CTD) closely associated involves a dissociation or springing-out …

Eccrine Poroma: The Prominent Mimicker, Nahla Shihab, Inge Ade Kristanti, Adhimukti T. Sampurna, Larisa Paramitha Wibawa

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Eccrine poroma (EP) is an adnexal benign tumor arising from the eccrine duct epithelium. The appearance of EP can mimic benign and malignant skin tumors, thus often making the diagnosis delayed or inaccurate.

Case Illustration: We report two cases of EP, with clinical and dermoscopic features mimicking Bowen’s disease, verruca vulgaris, pyogenic granuloma, skin metastases of breast cancer, and amelanotic melanoma. Both patients were surgically excised and biopsied. Histopathology examination of both cases revealed eccrine poroma.

Discussion: Both cases showed similarity with the theories, that EP is most found in middle age population and its predilection …

Efficacy Of Low Level Laser Therapy In The Treatment Of Postherpetic Neuralgia, Lili Legiawati, Marsha Bianti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) and defined as pain that persists for more than 90 days after the onset of HZ rash. The chronic pain of PHN is debilitating and often associated with significant morbidity. It is a neuropathic pain and manifests as allodynia, hyperalgesia, or spontaneous pain. Although it is not considered to be life-threatening, sometime HZ is inadequately treated and may result in more severe PHN. Various treatment protocols for PHN are available; however, the result remains unsatisfactorily. The use of low level laser therapy (LLLT) in pain management …

Cumulative Exposure To Solar Ultraviolet A & B Increases Apoptosis Of Peripheral Blood Cutaneous Lymphocyte Antigen (Cla)+ T-Lymphocytes In Outdoor Workers, Afif Nurul Hidayati, Saut Sahat Pohan, Widodo J. Pudjirahardjo, Isaac Effendy

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Exposure to ultraviolet A & B (UVA-UVB) plays a role in the survival of human life, but it may cause negative effects, such as immunosuppression and skin cancer. The effect of solar UVA-UVB exposure on apoptosis (Bax/Bcl-2 ratio) of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-lymphocyte; the immune competent cells in the skin, has not been investigated. Apoptosis of peripheral blood CLA+ Tlymphocyte affects its function; which serves as the skin's resistance and is involved in infectious diseases, skin inflammation, and malignancies. This study observed the effect of solar UVA-UVB to apoptosis (Bax/Bcl2 ratio) of peripheral blood CLA+ …

Profile Of Vitiligo Patients And Distribution Of Narrowband-Uvb Therapy At Dr. Cipto Mangunkusumo General Hospital, Lis Surachmiati Suseno, Putu Martha Gerynda Sukma, Rahadi Rihatmadja, Triana Agustin, Githa Rahmayunita, Endi Novianto

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Vitiligo is a disease marked by depigmented macules. Prevalence of vitiligo varies between 0.1- 2.3% worldwide. The objectives of this study are to identify the socio-demographic profile of vitiligo patients and distribution of narrowband-UVB given as a treatment modality. However, in Indonesia, including at dr. Cipto Mangunkusumo General Hospital, there has not been any study on the profile of vitiligo patients. Therefore, a preliminary study on the patients’ profile would be very useful for healthcare providers in calculating the need for narrowband-UVB equipment and evaluation of its current use.

Methods: A retrospective descriptive study, using secondary data …

Diagnostic Procedures In Pediatric Dermatology, Arini Astasari Widodo, Githa Rahmayunita, Triana Agustin, Rinadewi Astriningrum

Journal of General - Procedural Dermatology and Venereology Indonesia

Diagnostic procedures in pediatric dermatology are different and significantly more challenging than those in adult patients, especially on how to approach the patients. We need to acknowledge that pediatric patients have unique anatomical, physiological, and psychological aspects. Compared to adults, children have smaller procedure area, are less cooperative, and more difficult to understand. For these reasons, we should perform diagnostic procedures on children cautiously. Having extensive knowledge in this field can facilitate us to carry out an ethical, efficient, targeted procedure with less risk. This article reviewed the most appropriate, most comfortable, and least invasive diagnostic procedures for children. Some …

Elevated Homeostatic Model Assessment Of Insulin Resistance Level Increases The Risk Of Acne, Stefani Nurhadi, Igaa Praharsini, Aagp Wiraguna

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Insulin resistance and high carbohydrate diets are currently considered to be influential in acne aetiology. Insulin is a hormone that does not only regulate the concentration of blood glucose but also affects the production of sebum and through the Insulin Growth Factor-1 (IGF-1) receptor stimulates androgen synthesis which will increase the proliferation of keratinocytes duct and the production of sebum in acne of the pilosebaceous.

Methods: This is a cross sectional observational analytic study involving 38 acne patients and 38 controls. This study aims to determine whether the increase in Homeostatic Model Assessment of Insulin Resistance …

Patients' Perceptions And Patient-Reported Outcomes In Progressive-Fibrosing Interstitial Lung Diseases, Jeffrey J. Swigris, Kevin K. Brown, Rayid Abdulqawi, Ketan Buch, Daniel F. Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue

Internal Medicine Faculty Publications

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be …

Patients' Perceptions And Patient-Reported Outcomes In Progressive-Fibrosing Interstitial Lung Diseases, Jeffrey J. Swigris, Kevin K. Brown, Rayid Abdulqawi, Ketan Buch, Daniel F. Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue

Internal Medicine Faculty Publications

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be …

Ribonucleotide Reductase Inhibitor 3-Ap Induces Oncogenic Virus Infected Cell Death And Represses Tumor Growth, Lu Dai, Jungang Chen, Yueyu Cao, Luis Del Valle, Zhiqiang Qin

School of Medicine Faculty Publications

Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human malignancies, particularly Kaposi's Sarcoma (KS), which preferentially arise in immunocompromised patients such as HIV+ subpopulation while still lacking of effective therapeutic options. We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially regulated by the key oncogenic HGF/c-MET pathway in KSHV-related lymphoma cells. One of RR inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) effectively induced apoptosis of KSHV+ lymphomas and suppressed tumor progression . In the current study, we found that 3-AP treatment selectively inhibited the proliferation of KSHV-infected endothelial cells, the major cellular components of KS, through inducing DNA …