Medicine and Health Sciences Commons^™

Sporadic Creutzfeldt-Jakob Disease: A Case Report Of Rapidly Progressive Dementia, Diane Olski, Karissa Charles, Cristin Grant, Courtnee Harpine, Shannon Leonard, Sarah Puim

South Atlantic Division GME Research Day 2025

No abstract provided.

Diet Quality As Assessed By The Healthy Eating Index-2020 Among Individuals Diagnosed With And Without Type 2 Diabetes, Minghao Zhou, Hairui Yu, Renee Underwood, Hongning Cai, Tung Sung Tseng, Susu Luo

School of Public Health Faculty Publications

Background: Dietary management is key to preventing and controlling type 2 diabetes mellitus (T2DM). However, few studies have examined differences in Healthy Eating Index (HEI-2020) scores and components among individuals with and without diagnosed T2DM. This study aimed to assess gender differences in HEI-2020 scores and its 13 components by T2DM status. Methods: Using National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2018, this cross-sectional study analyzed 19,464 adults. Diagnosed T2DM was identified via self-report or diabetes medication use. Diet quality was assessed using the HEI-2020, scored from 0 to 100, with a higher HEI score indicates …

Reducing Acute Healthcare Services With Self-Management Of Blood Pressure Monitoring Through Remote Patient Monitoring For Hypertensive Patients A Quality Improvement Project, Becky J. Wagner

Doctor of Nursing Practice (DNP) Manuscripts

Hypertension (HTN) affects nearly half of U.S. adults and remains a leading cause of preventable emergency department (ED) visits, hospitalizations, and healthcare costs due to poor blood pressure (BP) control (Fryar et al., 2024; Mullins et al., 2019). Traditional care models often lack the continuous monitoring and timely intervention needed for effective chronic disease management. Remote Patient Monitoring (RPM) provides an innovative approach by delivering real-time BP data, enabling early clinical intervention, and encouraging patient engagement in self-management (Omboni et al., 2020).

This Doctor of Nursing Practice (DNP) project evaluated the effectiveness of an RPM intervention in reducing acute healthcare …

Bone, Muscle, And Physical Function Measures In Older Adults According To Levels Of Social Disadvantage: A Cross-Sectional Study, Jason Talevski, Sharon Brennan-Olsen, Stefanie Bird, Sara Vogrin, Alison Beauchamp, Mizhgan Fatima, Cassandra Smith, Gustavo Duque

Research outputs 2022 to 2026

Summary: This cross-sectional study of 300 older adults (aged ≥ 50 years) found that less education, lower income, and health care card ownership are associated with reduced bone, muscle, and physical function measures. This underscores the need for targeted preventive strategies for osteoporosis and sarcopenia that address socioeconomic-related disparities. Purpose: The prevalence of chronic diseases follows a social gradient, although this is unclear in musculoskeletal conditions. This study aims to examine the association between social disadvantage and diagnostic measures of osteoporosis and sarcopenia in community-dwelling older adults. Methods: A single-centre, cross-sectional study was conducted in adults (≥ 50 years) residing …

Body Composition And Muscle Health Changes After Providing Vascular Imaging Results In Older Adults: Secondary Analysis Of A Randomised Controlled Trial, Jack Dalla Via, Simone Radavelli-Bagatini, Marc Sim, Abadi K. Gebre, Catherine P. Bondonno, Kun Zhu, Shelby Mullin, John T. Schousboe, Richard J. Woodman, Markus P. Schlaich, Moira Sim, Pawel Szulc, Douglas P. Kiel, Wai H. Lim, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim: This secondary analysis of a 12-week parallel-group randomised controlled trial (RCT) aims to explore body composition and muscle health effects of providing healthy lifestyle education (Ed) with and without abdominal aortic calcification (AAC) results. Methods: A total of 240 Australian community-dwelling older men and women (mean ± SD age 68 ± 5 years; 58% female; 57.1% with evidence of AAC) were randomised to AAC + Ed (n = 121) or Control + Ed …

Cxcr3 Is Associated With T-Cell-Induced Heart Damage In Acute Rheumatic Fever, Francis M. Middleton, Reuben Mcgregor, Natalie Lorenz, Sarah Kilian, Anna E.S. Brooks, Saem Mul Park, Ciara Ramiah, Judith Tresidder, Timothy C. Barnett, Michael Serralha, William J. Martin, Florina Chan Mow, Glenn Pearson, Mark Mayo, David I. Broadhurst, Julie Bennett, Johann Brink, Nigel J. Wilson, Anna P. Ralph, Rachel H. Webb, P. Rod Dunbar, Jonathan Carapetis, Nicole J. Moreland

Research outputs 2022 to 2026

The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways. ARF shared immunological similarities with other inflammatory conditions, including elevated serum IL-6 and an increased frequency of circulating CD4⁺ T cells. However, elevation of the chemokine CCL5 and immunoglobulin IgG3, along with reduced expression of the chemokine receptor CXCR3 in the T cell …

Association Of Glycd147 With Carotid Atherosclerosis: Evidence From Integrative Analyses, Cuihong Tian, Yang, Xingang Li, Hongxia Zhang, Jieyi He, Jinxiu Zhu, Yequn Chen, Xuerui Tan

Research outputs 2022 to 2026

Background: Atherosclerosis is an inflammatory cardiovascular disease that progresses with ageing. Glycosylation plays a significant role in inflammation and contributes to the pathogenesis of ageing-related diseases, including atherosclerosis. Cluster of differentiation 147 (CD147), a glycosylated agonist of matrix metallopeptidase 9 (MMP9), serves as an inducer of atherosclerosis and atherothrombosis. However, the effect of glycosylated CD147 (GlyCD147) on atherosclerosis remains unclear. This research aims to identify whether GlyCD147 is associated with atherosclerosis. Methods: To begin with, a clinical case-control study was designed to assess the differences of CD147 and GlyCD147 between 69 carotid atherosclerosis (CAS) cases and 69 controls. Traditional atherosclerotic …

Graft Survival And Rejection With Repeated Human Leukocyte Antigen (Hla) Mismatch In Kidney Transplantation: A Retrospective Multicentre Cohort Study Protocol, Henry Guo, William Mulley, Narelle Watson, Rhonda Holdsworth, Anne Taverniti, Jon Downing, Alycia Thornton, Lucy Sullivan, Fiona Hudson, Christopher E. Davies, Ryan Gately, Armando Teixeira-Pinto, Germaine Wong, John Kanellis, Wai Lim

Research outputs 2022 to 2026

Background: Candidates awaiting repeat kidney transplantation face substantial immunological barriers due to prior human leukocyte antigen (HLA) allo-sensitisation. Re-exposure to previously mismatched HLA antigens may increase the risk of acute rejection and premature graft loss. Although avoidance of repeat HLA mismatches (RMM) has been standard practice, emerging evidence suggests this risk varies according to the specific HLA allelic RMM and anti-HLA antibody profile to the RMM. Here we describe the protocol for a retrospective registry-based cohort study that aims to determine the differences in graft outcome between recipients who received kidney transplants with and without RMM, and to examine the …

Characterization Of Regulation Of Ace2 And Morphogenesis (Ram) Pathway Components In Aspergillus Fumigatus, Devi Naga Jyothi Bale

Theses and Dissertations (ETD)

Aspergillus fumigatus CotA is a conserved protein kinase and predicted orthologue of Cbk1, a terminal kinase of the Regulation of Ace2 and Morphogenesis (RAM) network. In our previous study, disruption of CotA resulted in carbon source dependent invasive growth with the mutant exhibiting preferential growth on glucose but severely impaired growth on alternate carbon sources. This pathway in other fungi has been implicated in the regulation of morphogenesis, stress responses, and virulence, but this study is the first one to characterize it in the pathogenic filamentous fungus.  In yeast, the RAM network includes the CotA ortholog, Cbk1, and associated proteins, …

Short-Term Clinical Outcomes Of Intranasal Stem Cell–Derived Extracellular Vesicles In Small Dogs With Tracheal Collapse: A Pilot Study, Won-Joung Jaung, Gyo-Bin Choo, Bum-Kyu Choi, Ji-Hee Park, Ji-Min Yu, Hyun-Keun Oh, Jae-Bong Moon, Ju-Hyun An

The Thai Journal of Veterinary Medicine

Tracheal collapse is a common chronic airway disease in small-breed dogs, and conventional medical management often provides limited long-term clinical improvement. Stem cell–derived extracellular vesicles (EVs) have recently emerged as a promising cell-free therapeutic approach because of their anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the safety and preliminary clinical effects of intranasal administration of mesenchymal stem cell–derived extracellular vesicles (MSC-EVs) in dogs with naturally occurring tracheal collapse. Ten client-owned small-breed dogs diagnosed with tracheal collapse were enrolled in this pilot study. MSC-EVs were administered intranasally as a single dose. Clinical evaluations were performed at baseline and at …

Time To Antibiotic Administration In The Treatment Of Sepsis: A Retrospective Cohort Study, Dennis Anthony Cardriche, Grayson Carter, Thomas Matese

HCA Healthcare Journal of Medicine

Background

The 2026 Surviving Sepsis Campaign (SSC) guidelines recommend antimicrobial therapy within 1 hour for probable septic shock, while the Centers for Medicare and Medicaid Services (CMS) mandates a 3-hour window. Current literature presents conflicting evidence on whether these universal time thresholds yield a definitive survival benefit. This study aims to evaluate the real-world impact of delayed antibiotic administration on patient mortality and length of stay (LOS).

Methods

A retrospective cohort study was conducted analyzing 62 153 adult encounters with severe sepsis or septic shock at emergency departments (EDs) between December 31, 2023, and December 31, 2025. Time to first …

Laboratory Study Of A Waste Anesthetic Gas Mask Scavenging System To Reduce Airborne Pathogen Exposure For Health Care Workers In Post Anesthesia Care Units, Josh Horton, Trevor Lim, Andrew Kanach, John Moenning, James Mcglothlin, Bruce M. Applegate Sr.

HCA Healthcare Journal of Medicine

Introduction

A scavenging oxygen mask system (SOMS) utilizing house vacuum has been demonstrated to significantly reduce exposure of post anesthesia care unit (PACU) health care workers (HCWs) to waste anesthetic gases (WAGs). Therefore, it was proposed that the same system could also be used to protect HCWs in the PACU by reducing Infectious Respiratory Particles (IRPs) spread from patients who may harbor airborne infective pathogens, such as Mycobacterium tuberculosis, certain strains of influenza, and SARS-CoV-2.

Methods

A life-like adult manikin head equipped with a bio-aerosol Collison nebulizer was set up to simulate patients exhausting pathogenic droplets. Further evaluation of …

Systemic Treatment Considerations For Psoriasis In Alpha-Gal Syndrome: A Case Report And Ingredient Review, Emily Saurborn, Ian Depew, Madelyn Ross, Mckenzie Lambiotte, Shane Cook

Marshall Journal of Medicine

Background: Psoriasis is a chronic skin condition characterized by an overactive immune system, leading to increased keratinocyte proliferation and angiogenesis. Treatment ranges from topical solutions to systemic therapy and lastly, biologics. However, the latter options are typically manufactured with mammalian-derived ingredients. Alpha-gal syndrome (AGS) is an acquired IgE-mediated hypersensitivity reaction to galactose-alpha-1,3-galactose, an enzyme required for digesting carbohydrates in mammalian products. In addition to dietary avoidance of mammalian products, patients with AGS may need to avoid certain medications due to their formulations.

Case Presentation: We present a case of a 53-year-old female with a severe alpha-gal allergy evaluated in the …

The Role Of Local Protein Sources In Nutritious And Balanced Complementary Feeding For The Prevention Of Stunting In Infants Aged 6-24 Months, Kysara Aureldy Davonso Matualage, Leonardo Tedjaprasadja, Chy'as Diuranil Astrid Permataputri

Indonesian Journal of Public Health Nutrition (IJPHN)

Stunting remains a major public health problem in Indonesia, with prevalence rates still above national targets. The complementary feeding period (6–24 months) is a critical window for prevention, during which inadequate protein intake significantly contributes to impaired linear growth. Local animal protein sources offer an accessible and sustainable strategy to improve dietary quality. This study aims to review scientific evidence on the role of local animal protein sources in nutritionally balanced complementary feeding for the prevention of stunting in Indonesian infants aged 6–24 months. A literature review was conducted by systematically searching scientific databases for studies published between 2020 and …

Development And Nutritional Evaluation Of Plantain–Soy Composite Flour Blends As Complementary Foods For The Management Of Protein-Energy Malnutrition, Jelili A. Quadri Dr., Azeesat O. Adebiyi-Olabode Dr, Anifat B. Saka Mrs., Debbie M. Esekhade Miss

Indonesian Journal of Public Health Nutrition (IJPHN)

Protein energy malnutrition (PEM) continues to be a critical problem in public health, especially in developing nations where sources of affordable nutrient-dense foods are unavailable. Plantain is one of the staple foods rich in carbohydrates but deficient in protein, while soybeans are protein-rich legumes. A blend of these local foods in composite flour will increase the nutritional value of plantain-based foods without compromising their sensory properties. The objective of this study was to formulate plantain-soy composite flour blends at various substitution rates and determine their composition and sensory characteristics. Unripe plantain and soybean were milled into flour and mixed in …

Factors Associated With The Incidence Of Hypertension In Young Adults (20–24 Years) In Central Kalimantan Province (Analysis Of Ski 2023 Data), Indira Paramesti, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Kusharisupeni Joko Suyono

Indonesian Journal of Public Health Nutrition (IJPHN)

Hypertension has been identified as a major public health problem leading to premature death and contributing to the development of various non-communicable diseases. In recent years, it has occurred not only among older populations but also among young adults. Hypertension at a young age can result in earlier organ damage, leading to a more rapid decline in quality of life and productivity. This study aimed to determine the risk factors associated with the incidence of hypertension among young adults aged 20–24 years in Central Kalimantan Province in 2023. A cross-sectional design was employed, utilizing secondary data from the 2023 Indonesian …

A Comparison Of Iron-Folic Acid Supplement Consumption Among Female Undergraduate Students In Health And Non-Health Majors At The University Of Indonesia In 2026, Naila Afifah, Ratu Ayu Dewi Sartika, Triyanti Triyanti, Deasy Martini

Indonesian Journal of Public Health Nutrition (IJPHN)

Iron-Folic Acid Tablets (IFAT) are recommended to prevent anemia among adolescent girls and women of reproductive age. However, IFAT consumption remains a concern among female college students, with previous research reporting differences in non-adherence between female health and non-health students at the University of Jember. This study aimed to analyze IFAT consumption behavior and its associations with residential status, attitudes, mother’s education, IFAT side effects, IFAT accessibility, media, family support, peer support, and healthcare provider support among female undergraduate students in health and non-health majors at the University of Indonesia in 2026. A cross-sectional study with purposive sampling was conducted …

Association Of Chrononutrition Behaviors And Other Factors With Nutritional Status Among Dormitory Students Of Universitas Indonesia In 2026, Hana Maulani Putra, Ratu Ayu Dewi Sartika, Trini Sudiarti, Fathimah Sulistyowati Sigit

Indonesian Journal of Public Health Nutrition (IJPHN)

Overweight and obesity remain major public health concerns in Indonesia and may be influenced by various factors, including chrononutrition behaviors related to meal timing and eating frequency, snacking habits, physical activity, sleep patterns, stress levels, ultra-processed food (UPF) consumption, allowance, and sex. Students living in dormitories may experience lifestyle changes associated with greater independence, which can affect their nutritional status. This study aimed to analyze the association between chrononutrition behaviors and other factors with the nutritional status of dormitory students at Universitas Indonesia in 2026. This cross-sectional study was conducted from April to May 2026. Participants were recruited using purposive …

Dominant Factors Associated With The Risk Of Chronic Energy Deficiency (Ced) Among Pregnant Women In East Nusa Tenggara Province (Analysis Ski Data 2023), Keisa Dwinta Mailova, Triyanti Triyanti, Tria Astika Endah Permatasari

Indonesian Journal of Public Health Nutrition (IJPHN)

Chronic Energy Deficiency (CED) is a long-term condition of energy deficiency resulting from inadequate nutrient intake. CED in pregnant women has negative effects on both maternal and fetal health. East Nusa Tenggara (NTT) Province is one of the regions with the highest prevalence of CED among pregnant women in Indonesia, with national data from 2023 showing a prevalence rate of 28%. This study aims to identify the dominant factors associated with the risk of CED in pregnant women in NTT. The study design is cross-sectional, utilizing secondary data from the 2023 Indonesia Health Survey (SKI), involving a sample of 215 …

Millets As A Preventive Dietary Intervention For India’S Nutrition Transition: A Narrative Review Of Glycaemic And Micronutrient Evidence, Kundan Kaushal, Manisha Upadhyay, Shambhu Nath Dubey, Indrajeet Kumar Jha

Indonesian Journal of Public Health Nutrition (IJPHN)

India’s nutrition profile reflects a nutrition transition rather than a single narrative: a rapidly escalating burden of diet-related non-communicable disease, including an estimated 101 million people with diabetes, coexists with a severe and worsening burden of micronutrient deficiency, with anaemia affecting 57% of women and 67.1% of children. This narrative review examines millets, small-seeded cereals historically marginalised in Indian diets in favour of rice and wheat, as a preventive dietary intervention with plausible relevance to both ends of this transition. Evidence was drawn from peer-reviewed systematic reviews and meta-analyses, national survey data and documented delivery interventions, identified through searches of …

Genitourinary Syndrome Of Menopause And Lower Urinary Tract Symptoms: A Primary Care Approach, Michelle Johnson

Lynchburg Journal of Medical Science

This literature synthesis reviewed current evidence on the pathophysiology, diagnosis, and management of genitourinary syndrome of menopause (GSM)-related lower urinary tract symptoms (LUTS) in postmenopausal persons, with implications for primary care. GSM is a chronic, progressive condition caused by estrogen deficiency affecting vaginal, urethral, and bladder tissues. An estimated 50% to 70% of postmenopausal persons experience symptoms, including urinary urgency, frequency, incontinence, and recurrent urinary tract infections. Despite its prevalence and effect on quality of life, GSM remains substantially underdiagnosed: fewer than half of symptomatic persons seek treatment, and clinicians often fail to screen proactively. Low-dose vaginal estrogen therapy remains …

Use Of The Well-Star Model And Well-Star Graphic In Healthcare, Fidan Korkut-Owen, Zubeyde Akpakir, Dean W. Owen

Journal of Wellness

No abstract provided.

Contraception Or Complication: A Review Of Depo-Provera’S Pharmacology And Public Health Implication, Phylicia Carpenter

Best Integrated Writing

This review article explores the link between progestogens and meningioma risk and outlines the biological mechanisms that may contribute to tumorigenesis. Two progestogens are emphasized through the paper: cyproterone acetate and medroxyprogesterone acetate (Depo-Provera). An important French study examining the relationship between progestogens use and meningioma risk is discussed, along with the health risks associated with long-term use. Additionally, this review advocates for increased routine prescriber-patient consultations and stronger drug regulation to educate and protect patients, particularly those experiencing socioeconomic disadvantages. It is important to note that the FDA recently updated the label for injectable medroxyprogesterone acetate in December 2025 …

Best Integrated Writing Fall 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Implementation Of A Modified Trigger Tool For Adverse Drug Reaction Detection In Pediatric With Covid-19 In Indonesia, Nisa Maria, Avini Risda Khaerani, Indri Yuliani Hamdani, Annisa Lazuardi Larasati, Larasati Arrum Kusumawardani

Pharmaceutical Sciences and Research

Pediatric patients are vulnerable to adverse drug reactions (ADRs), necessitating prompt monitoring of treatment-related adverse events (AEs). This study analyzed ADRs in pediatric COVID-19 patients using a modified trigger tool to identify AEs, followed by causality analysis with the Naranjo Algorithm, and evaluated the tool’s performance. A cross-sectional, single-center retrospective study was conducted at a hospital in Indonesia from August 2020 to July 2021, using total sampling of pediatric patients aged one to≥24 hours with COVID-19. AEs were identified using 23 triggers (15 laboratory result, eight drug-administration). A total of 242 positive triggers were detected among 120 patients (mean two …

Murine Typhus In Georgia: Historical Context And A Probable Case Of Resurgence Where Previously-Thought Eradicated, Giovanni Mella-Velazquez, Christopher He, Bolanle Akinsola, Judson Miller

Journal of the Georgia Public Health Association

Background: Murine typhus, caused by Rickettsia typhi, is a flea-borne illness historically endemic to the southeastern United States, with initial cases reported in Atlanta, Georgia in 1913. Following vector control efforts, incidence declined significantly, and the disease was removed from the nationally notifiable disease list in 1987. While recent cases have been reported in select regions, murine typhus has not been documented in Georgia for decades. We present a pediatric case in Atlanta that may represent the first reported instance in nearly 40 years, suggesting possible reemergence in the Southeast.

Methods: We conducted a case report analysis of a pediatric …

Evaluating The Quality And Safety Of A Nurse Practitioner-Led Virtual Clinic For Secondary Prevention In Stable Coronary Artery Disease: A Pilot Feasibility Study., Anwar Abdi, Holly Rector, Vivian Hung, Shadi Akhtari

Medical Education Articles

Background Virtual care offers a complementary pathway to in-person visits for managing coronary artery disease (CAD). This study evaluated the feasibility of a nurse practitioner (NP)-led interdisciplinary virtual clinic dedicated to secondary prevention for individuals with stable CAD.

Methods A feasibility study was conducted in an academic cardiology practice in Canada from July 2021 to July 2024. A convenience sample of adults ≥18 years of age with stable CAD was included; each participant received at least one annual NP-led video visit reviewed with a cardiologist asynchronously. Primary outcomes: 1) percentage of self-reported maintenance of guideline-directed medical therapies (GDMT) and achieving …

Beyond Screening In Amyotrophic Lateral Sclerosis: A Domain-Standardized, Measure-Flexible Framework For Comprehensive Neuropsychological Assessment, Etiane Navarro

Archives of Assessment Psychology

Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder in which cognitive, behavioral, language, and social-cognitive changes may occur across clinical phenotypes, including the ALS-frontotemporal spectrum. Neuropsychological assessment is important for characterizing nonmotor manifestations and identifying changes relevant to autonomy, everyday functioning, and clinical management. This systematic review examined literature identified through APA PsycINFO, PubMed, Google Scholar, and supplementary searching to characterize neuropsychological domains, measures, phenotype-related findings, and disease-specific limitations relevant to comprehensive assessment. Two hundred records underwent title and abstract screening, 150 reports were reviewed in full text, and 61 resources were retained for synthesis. ALS-specific screening instruments, including …

In-Home Free-Living Gait Monitoring Using A Single Lumbar Imu Reveals Nonlinear Complexity Changes During Intensive Stroke Rehabilitation, Rahul Soangra, Susan V. Duff, Alison Mckenzie

Physical Therapy Faculty Articles and Research

Conventional clinical assessments of stroke rehabilitation are limited to supervised environments and fail to capture continuous real-world motor behavior. This proof-of-concept pilot study (case series, n = 3) evaluated the feasibility and longitudinal sensitivity of wearable IMU-derived digital biomarkers of three individuals with chronic stroke across Chapman University’s Stroke Boot Camp (SBC), a two-week intensive interdisciplinary rehabilitation program. A lower-back-mounted DynaPort McRoberts IMU provided continuous multi-day free-living monitoring across five sessions that spanned one week pre-intervention through to three months post-intervention. A validated Python-based pipeline implemented Mobilise-D gait sequence detection, wavelet-based heel strike and toe-off identification, and extraction of linear …

Beyond Screening In Amyotrophic Lateral Sclerosis: A Domain-Standardized, Measure-Flexible Framework For Comprehensive Neuropsychological Assessment, Etiane Navarro

Archives of Assessment Psychology

Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder in which cognitive, behavioral, language, and social-cognitive changes may occur across clinical phenotypes, including the ALS-frontotemporal spectrum. Neuropsychological assessment is important for characterizing nonmotor manifestations and identifying changes relevant to autonomy, everyday functioning, and clinical management. This systematic review examined literature identified through APA PsycINFO, PubMed, Google Scholar, and supplementary searching to characterize neuropsychological domains, measures, phenotype-related findings, and disease-specific limitations relevant to comprehensive assessment. Two hundred records underwent title and abstract screening, 150 reports were reviewed in full text, and 61 resources were retained for synthesis. ALS-specific screening instruments, including …