Medicine and Health Sciences Commons^™

Health-Related Quality Of Life And Chronic Obstructive Pulmonary Disease In North Carolina, David Brown, Roy Pleasants, Jill Ohar, Monica Kraft, James Donohue, David Mannino, Winston Liao, Harry Herric

David C. Brown

Background:

Comparisons of health-related quality of life (HRQOL) between persons with chronic obstructive pulmonary disease (COPD) and adults in the general population are not well described.

Aims:

To examine associations between COPD and four measures of HRQOL in a population-based sample.

Patients & Methods:

These relationships were examined using data from 13,887 adults aged >18 years who participated in the 2007 Behavioral Risk Factor Surveillance System (BRFSS) conducted in North Carolina (NC). Logistic regression was used to obtain adjusted relative odds (aOR).

Results:

The age-adjusted prevalence of COPD among NC adults was 5.4% (standard error 0.27). Nearly half of adults …

Chapter 5. Chronic Obstructive Pulmonary Disease (Copd), David Mannino, Janet Croft, David Brown

David C. Brown

No abstract provided.

In Vitro Haematopoiesis Of A Novel Dendritic-Like Cell Present In Murine Spleen, Jonathan Tan, Helen O'Neill

Jonathan Tan

Abstract: Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for haematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell …

Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill

Jonathan Tan

Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restricted in vitro development of only L-DC in these stromal cultures, we questioned whether self-renewing HSC or progenitors exist in spleen with restricted differentiative capacity for only L-DC. Neonatal spleen and BM were compared for their ability to reconstitute mice …

Occupational Science: A Data-Based American Perspective, Doris Pierce, Karen Atler, Julie Baltisberger, Elaine Fehringer, Elizabeth Hunter, Somaya Malkawi, Twilia Parr

Julie A. Baltisberger

The purpose of this research was to provide a data-based picture of the discipline of occupational science by identifying patterns of research in the first 5 years of presentations at the Society for the Study of Occupation: USA (SSO:USA). A grounded theory approach was used to examine 184 peer-reviewed presentation abstracts, from 2002 to 2006. Among the 108 data-based presentations, adults were the most studied group, with 46% of the data-based abstracts focused on participants with a disability or clear disadvantage. Presenters’ research foci related to 4 themes: the personal experience of occupation, the context surrounding or impacting occupation, changes …

(Invited) Instructor For Ce Class, “Nlm Pubmed/Medline Basics: Locating Hidden Treasures In Radiology”, Marilia Antunez

Marilia Y. Antunez, MLS, MA

Also provided research assistance to radiologists attending the 2007, 2009, and 2010 RSNA Annual Conferences in English and Spanish.

Motivational Interviewing (Mi) Using Co-Active Life Coaching Skills As A Treatment For Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.

Self-Assessed Emergency Readiness And Training Needs Of Nurses In Rural Texas, Holly Jacobson, Francisco Soto Mas, Chiehwen Hsu

Francisco Soto Mas

Nurses are potential first responders in the case of an emergency, and should play a key role in bioterrorism preparedness and response. The role of nurses becomes more critical in rural areas where local health departments are absent and health professionals are scarce. Given that nurses’ capacity to act will be vital to an emergency response in a rural community, it is imperative to determine their current level of bioterrorism training. The purpose of this study was to assess the level of bioterrorism-related preparedness and training needs of the nursing workforce in Regions 2 and 3 of the Texas Department …

Retention In Care Among Hiv-Infected Patients In Resource-Limited Settings: Emerging Insights And New Directions, Elvin Geng, Denis Nash, Andrew Kambugu, Yao Zhang, Paula Braitstein, Katerina Christopoulos, Winnie Muyindike, Mwebesa Bwana, Constantin Yiannoutsos, Maya Petersen, Jeff Martin

Elvin H Geng

In resource-limited settings—where a massive scale up of HIV services has occurred in the last 5 years—both understanding the extent of and improving retention in care presents special challenges. First, retention in care within the decentralizing network of services is likely higher than existing estimates that account only for retention in clinic, and therefore antiretroviral therapy services may be more effective than currently believed. Second, both magnitude and determinants of patient retention vary substantially and therefore encouraging the conduct of locally relevant epidemiology is needed to inform programmatic decisions. Third, socio-structural factors such as program characteristics, transportation, poverty, work/child care …

Effects Of Distributed Constraint-Induced Therapy On Trunk Control, Daily Function, And Quality Of Life In Patients With Chronic Stroke, Yi-An Chen, Keh-Chung Lin, Ching-Yi Wu, Yin-Chou Lin, Ngok-Kiu Chu, Jyh-Yuh Ke, Pei-Hsuan Wu

Rehabilitation Practice and Science

Objective: Patients commonly have impaired arm trunk coordination following a stroke. The trunk compensation often used by stroke patients may hinder recovery of the affected arm. Given that the extent to which constraint-induced therapy (CIT) affects arm-trunk coordination has not been investigated previously, this study examines how distributed CIT (dCIT) affects arm trunk coordination and trunk compensation strategy, as well as functional performance and quality of life.Materials and Methods: Sixteen participants (at least 6 months post-onset) after stroke were randomly assigned to either the dCIT group which received training 2 hours daily for 3 weeks, with the unaffected arm restrained …

Effect Of Perceptual Interference And Response Conflict On P300 Latency, Yu-Shen Huang, Fen-Fen Chen

Rehabilitation Practice and Science

Background: The latency of the P300 component of the event related-potential (ERP) is an index of stimulus classification speed. In this study, we assessed the mental chronometry of stimulus discrimination and decision execution by study the effect of congruence visual stimuli and and compatibility on ERP and reaction time.Methods: The reaction time was divided into two sections based on the peak amplitude of P300. P300 latency was defined as the discrimination time needed to interpret the stimulus. The time from the peak of P300 to the initiation of movement was defined as duration of response selection. We hypothesized that congruency …

Radicular Pain As An Initial Presentation In Neuromyelitis Optica: A Casereport, Yen-Chou Lai, Wen-Sheng Liu, Shih-Fan Lin, Tsam-Ming Kuo, Ker-Hsiu Liao, Yen-Ting Lai

Rehabilitation Practice and Science

Neuromyelitis optica is a rare demyelinating disease. Radicular pain as the initial presentation of monophasic neuromyelitis optica has not been previously reported. We present a case of monophasic neuromyelitis optica in a 69-year-old female who suffered 1 year (from 2004/6 to 2005/5) from back pain that radiated to the lower extremities. Fifth lumbar radiculopathy was the first diagnosis. Despite treatment with laser discectomy on 2005/2/15, her pain, lower extremity weakness, and bilateral visual acuity worsened. Three weeks after surgery, she came to our hospital for help and was admitted for evaluation. The diagnosis of neuromyelitis optica was confirmed later. Prednisolone …

Multiple Heterotopic Ossifications In A Patient With Traumatic Brain Injury And Femoral Fracture: A Casereport, Chun-Sheng Ho, Chein-Wei Chang, Eou-Ting Hsieh, Jen-Li Pan

Rehabilitation Practice and Science

Sporadic heterotopic ossification is a common complication in patients with spinal cord injury, traumatic brain injury, electrical burns, hip fracture, elbow fracture or total hip arthroplasty. However, multiple heterotopic ossifications in a traumatic brain injury case are quite rare. We report a case of a 23 year-old female patient with traumatic brain injury and a right femoral open fracture due to a traffic accident. She started to develop local erythema, swelling, warmth and pain over the left elbow and right hip about two months after the accident. The range of motion of the affected joints decreased and this severely impeded …

Primary Reasons For Rehabilitation Service Referrals: The Recent Experience Of A Medical Center In Taiwan, Chung-Po Su, Ssu-Yuan Chen, Tyng-Guey Wang, Yen-Ho Wang, I-Nan Lien

Rehabilitation Practice and Science

Objectives: To better understand the current utilization of rehabilitation services and to project future trends, this study investigated the primary reasons for rehabilitation services referrals in a medical center in Taiwan. Methods: We reviewarticleed records of those patients who visited rehabilitation clinics (4,305 new and 12,163 returned patients) or received a rehabilitation consultation during their hospital stay (1,345 patients) between June and October 2007 at the National Taiwan University Hospital. The primary diagnoses of study patients were classified into 12 groups: musculoskeletal and soft tissue diseases, brain diseases, spinal cord diseases, peripheral neuropathy, myopathy, fractures and amputations, language disorders, cardiovascular …

Enhancement Of Reactive Oxygen Species Production And Chlamydial Infection By The Mitochondrial Nod-Like Family Member Nlrx1, Ali A. Abdul-Sater, Najwene Saïd-Sadier, Verissa M. Lam, Bhavni Singh, Matthew A. Pettengill, Fraser Soares, Ivan Tattoli, Simone Lipinski, Stephen E. Girardin, Philip Rosenstiel, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Chlamydia trachomatis infections cause severe and irreversible damage that can lead to infertility and blindness in both males and females. Following infection of epithelial cells, Chlamydia induces production of reactive oxygen species (ROS). Unconventionally, Chlamydiae use ROS to their advantage by activating caspase-1, which contributes to chlamydial growth. NLRX1, a member of the Nod-like receptor family that translocates to the mitochondria, can augment ROS production from the mitochondria following Shigella flexneri infections. However, in general, ROS can also be produced by membrane-bound NADPH oxidases. Given the importance of ROS-induced caspase-1 activation in growth of the chlamydial vacuole, we investigated the …

The Effect Of Body Weight Support Treadmill Training On Walking Ability In Patients With Incomplete Spinal Cord Injury, Chien-Hsing Tseng

Rehabilitation Practice and Science

In modern health care systems that attach importance to acute treatment and health care, there is an increasing number of patients with incomplete spinal cord injury that have increased chance of regaining their ability to walk. However, how to effectively achieve this target of promoting the ability to walk is a question that must be urgently addressed by rehabilitation medicine and public health authorities. International research has already confirmed that body weight support treadmill training has a positive therapeutic effect on walking ability in patients with incomplete spinal cord injury, but in Taiwan not many relevant studies have been performed. …

The Prevalence Of Flatfoot In Taoyuan Teenagers, Huan-Jui Yeh, Huei-Yu Lo, Yau-Wai Wai

Rehabilitation Practice and Science

Background: The prevalence of flatfoot is various among each age group, and whether children with flatfoot should receive treatment or not is still controversial. Most studies of flatfoot in Taiwan place emphases on children but not on teenagers. This research aimed to establish a database of a prevalence of flatfoot among Taiwanese local teenagers.Methods: Five hundred forty-four 12- to 14-year-old teenagers in Taoyuan were enrolled in this study. Footprint analysis methods were used to diagnose a flatfoot (plantar arch index more than 1.15 or Denis grade equal or more than grade 1 or footprint index less than 1 cm). The …

Orthostatic Postural Deficit In Subjects With Streptococcal Serology-Related Unclassified Arthritis Of The Lumbopelvis, Shao-Chi Lu, Liang-Cheng Chen, Shang-Lin Chiang, Tsung-Ying Li, Yau-Ren Tseng, Shin-Tsu Chang, Chen-Chung Dai

Rehabilitation Practice and Science

Titers of antistreptolysin-O (ASO) possess the diagnostic value in discriminating post-streptococcal reactive arthritis. Patients are labeled as ”unclassified arthritis” (UA) while hard to be classified as having a well-defined arthropathy. Posture is important to perform activities of daily living and its abnormality is a negative factor for trunk stability and balance. We hypothesized that an imbalance of the lumbopelvis due to sacroiliac joint disorder might produce a positional change. The purpose of this study was to determine whether there was a difference in postural sway during orthostatic standing in subjects with UA of the lumbopelvis and high ASO titers. All …

Efficacy Of Wii(Superscript Tm)-Based Virtual Reality Assisted Rehabilitation For Chronic Stroke Patients, Zheng-Yu Hoe, Jue-Long Wang, Yuk-Keung Lo, Shu-Fen Sun, Chao-Hung Chang, Hsin-I Tsai

Rehabilitation Practice and Science

Virtual reality assisted rehabilitation provides the opportunity for a safe training environment, allows intensive practice using repetitive tasks, provides real-time auditory and visual performance feedback and also may augment patients’ motivation. Wii(superscript TM) has all of these advantages. In addition, it is relatively cheap and thus it is affordable and practical to be used in clinical settings. We recruited patients with chronic stroke (＞1 yr) and limb function impairment. All patients participated in the Wii(superscript TM)-based virtual reality assisted rehabilitation program with a minimum of 30 minutes/session, three times/week for 3 months. The patients' cognitive function, motor function of both …

Dysphagia After Anterior Cervical Spine Surgery: A Casereport, Hsi-Ting Chiu, Ssu-Yuan Chen, Tyng-Guey Wang, Yen-Ho Wang

Rehabilitation Practice and Science

Dysphagia is one of the complications that develops after anterior cervical spine surgery. Its etiology is multifactorial. It is transient in most patients, and few patients suffer from dysphagia for more than several months. This study reports 1 patient with a dislocation fracture at the C5-C6 level who suffered from dysphagia for 6 months after the anterior cervical spine surgery. Videofluoroscopic examination of swallowing revealed pharyngeal muscle weakness and cricopharyngeal muscle dysfunction with obstruction at the level of the left upper esophageal sphincter. Serial examination revealed neither laryngeal organic lesions, such as those observed in vocal cord palsy, nor evidence …

Analysis Of Phonological Disorder Among Preschool Children, Shao-Li Han, Yen-Chi Chen, Hsiao-Yu Yen, Ya-Wen Tu, Tsung-Yu Wei

Rehabilitation Practice and Science

Speech sound errors have been noted as the most common speech disorder among children. However, recent studies about pronunciation errors among preschool children are lacking. Our aim was to evaluate the characteristics and frequency of pronunciation errors among pre-school children with phonological disorder in Taiwan. Between December 2006 and November 2008, we recruited children visiting our outpatient department for evaluation of speech sound errors. Children with speech delay, hearing loss, mental retardation, orofacial abnormalities, chromosomal abnormalities and other pervasive developmental disorders identified by clinical evaluation and clinical birth histories acquired from their families were excluded. Finally, 126 children who met …

Moyamoya Disease Presenting With Hemichorea: A Casereport, Min-Hsin Lai, Shin-Yo Lu, Pei-Chi Chou, Shin-Tsu Chang, Heng-Yi Chu

Rehabilitation Practice and Science

We report an unusual case of a 13-year-old boy with moyamoya disease whose predominant manifestation was right hemichorea with initial dystonic spasms of the right limbs and face. A diffusion-weighted MR image of the brain in the initial stage showed no infarcted or other parenchymal lesions. However, MR angiography and intracranial angiography showed stenosis of the bilateral internal carotid and middle cerebral artery with prominent basal collaterals, which was compatible with moyamoya disease. Chorea or hemichorea is one of the rarer presenting features of moyamoya disease. Our findings suggest that moyamoya disease should be included in the differential diagnosis of …

Posterior Interosseous Neuropathy Related To Cumulative Trauma Disorder: A Casereport, Cheng-Hao Tseng, Tsung-Cheng Huang, Jen-Wen Hung, Bin-Chi Chang

Rehabilitation Practice and Science

Work related cumulative posterior interosseous neuropathy is a rare cumulative trauma disorder. To the best of our knowledge, a locksmith with this kind of disorder has never been reported. The locksmith was a 57-year-old man, and he had to perform repeated supination and pronation movements when working. He complained of weakness of right third and fourth finger extension when typing on a computer keyboard. Radial deviation was also noted when his wrist was extended. Electromyography was performed and right posterior interosseous neuropathy was suspected. Magnetic resonance imaging (MRI) showed perineural muscle edema, obliteration and fluid accumulation at the level of …

Papillary Thyroid Carcinoma With Neck Pain: A Casereport, Shih-Wei Huang, Nai-Chiung Huang, Ta-Sen Wei, Tsung-Ju Wu

Rehabilitation Practice and Science

Papillary thyroid carcinoma is a type of well-differentiated thyroid cancer. This type of cancer is often diagnosed in patients found with palpable neck mass or lymph node enlargement. The clinical characteristics of papillary thyroid carcinoma are slow disease progression, less tendency for distant metastasis, and better prognosis than other types of thyroid cancer. The diagnosis of thyroid cancer is primarily based on the identification of pathological tissue obtained through echo-guide fine needle aspiration biopsy. In laboratory examinations, these patients may or may not be present with hypothyroidism.The subject in our case study is a 82-year-old male patient. He complains of …

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

USF Tampa Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We …

Result Of Low Frequency Speech Therapy In Children With Articulation Disorder, Yu-Nan Wang, Mei-Li Cheng, Ya-Wen Li, Xiao-Jun Zhang

Rehabilitation Practice and Science

Articulation disorder refers to the mispronunciation of speech sounds by omitting, distorting, substituting, or adding sounds which make speech difficult to understand. It is not an uncommon disorder among children. The prevalence of articulation disorder in preschool and school-age children is about 10%. For children without associated condition, articulation disorder may be treatable with speech therapy. In this study, we examined 55 children with articulation disorder who received speech therapy in our hospital during the past four years. The boys to girls ratio is 2.4 to 1. Among the different types of articulation disorders, substitution is the most common type …

Clinical Outcomes Of Rehabilitation On An 11-Year-Old Girl With Devic's Syndrome: A Casereport, Cheng-Cheng Hsu, Wen-Chih Lin, Tan-Hwui Lau, Ming-Chi Lai, Rong-Bin Hong, Wei-Ni Chou

Rehabilitation Practice and Science

Devic's syndrome-neuromyelitis optica (NMO), a rare demyelinating central nervous system diseases, must be clinically differentiated from multiple sclerosis (MS). The diagnostic criteria of Devic's syndrome include optic neuritis, acute myelitis, and at least two of the three symptoms below: brain MRI different from MS, three or more consecutive spinal segments invaded on MRI, and NMO-IgG seropositive.The case prevails over females aged 30-40 years. The courses of Devic's syndrome could be categorized in two types: single invasion and recurrence. The latter has poorer prognosis. The medical treatment mainly lies in immune modulation and the rehabilitative intervention including retaining life functions, preventing …

Ultrasonographic Diagnosis Of A Knee Prosthesis Polyethylene Loose Body: A Casereport, Ying-Fang Chen, Yi-Pin Chiang, Baii-Jia Yang

Rehabilitation Practice and Science

Polyethylene is an important component of a knee prosthesis, but wear of this material is one of the most frequent complications following total knee arthroplasty. Diagnosis of polyethylene wear is based mainly on history, physical examination, and plain radiographs. However, even when the damage is severe, plain radiographs may not be so sensitive enough to detect the debris. Musculoskeletal ultrasound is infrequently used to evaluate the operated knee, but it is a sensitive method for evaluating the polyethylene component of a knee prosthesis.We report an 80-year-old woman who had a painful, enlarging, inflamed mass on her left knee. She had …