Medicine and Health Sciences Commons^™

A Consortium Developed Poster To Teach Evidence-Based Health Care. (Poster), Kristine Petre, Linda Schwartz

Linda Matula Schwartz MDE, AHIP, CM

No abstract provided.

What's Happening: December 29, 1999, Maine Medical Center

What's Happening

No abstract provided.

Integration Of Calcium And Cyclic Amp Signaling Pathways By 14-3-3, Chi-Wing Chow, Roger J. Davis

Open Access Publications by UMass Chan Authors

Calcium-stimulated nuclear factor of activated T cells (NFAT) transcription activity at the interleukin-2 promoter is negatively regulated by cyclic AMP (cAMP). This effect of cAMP is mediated, in part, by protein kinase A phosphorylation of NFAT. The mechanism of regulation involves the creation of a phosphorylation-dependent binding site for 14-3-3. Decreased NFAT phosphorylation caused by the calcium-stimulated phosphatase calcineurin, or mutation of the PKA phosphorylation sites, disrupted 14-3-3 binding and increased NFAT transcription activity. In contrast, NFAT phosphorylation caused by cAMP increased 14-3-3 binding and reduced NFAT transcription activity. The regulated interaction between NFAT and 14-3-3 provides a mechanism for ...

The Effects Of Anorexia Nervosa On Bone Metabolism In Female Adolescents, Leslie A. Soyka, Steven K. Grinspoon, Lynne L. Levitsky, David B. Herzog, Anne Klibanski

Endocrinology/Diabetes

Osteopenia is a frequent, often persistent, complication of anorexia nervosa (AN) in adolescent girls and occurs during a critical time in bone development. Little is known about bone metabolism in this patient population. Therefore, we measured bone density (BMD) and body composition by dual energy x-ray absorptiometry, nutritional status, bone turnover, calcium, and hormonal status in 19 adolescent girls with AN (mean +/- SEM, 16.0+/-0.4 yr) and 19 bone age-matched controls. The mean duration of AN was 19+/-5 months. Spinal (L1-L4) osteopenia was common in AN. Lumbar anterioposterior BMD was more than 1 SD below the mean ...

The Ccaat Displacement Protein/Cut Homeodomain Protein Represses Osteocalcin Gene Transcription And Forms Complexes With The Retinoblastoma Protein-Related Protein P107 And Cyclin A, Maria F. Van Gurp, Jitesh Pratap, Mai X. Luong, Amjad Javed, Heidi M. Hoffmann, Antonio Giordano, Janet L. Stein, Ellis J. Neufeld, Jane B. Lian, Gary S. Stein, Andre J. Van Wijnen

Open Access Publications by UMass Chan Authors

Developmental control of bone tissue-specific genes requires positive and negative regulatory factors to accommodate physiological requirements for the expression or suppression of the encoded proteins. Osteocalcin (OC) gene transcription is restricted to the late stages of osteoblast differentiation. OC gene expression is suppressed in nonosseous cells and osteoprogenitor cells and during the early proliferative stages of bone cell differentiation. The rat OC promoter contains a homeodomain recognition motif within a highly conserved multipartite promoter element (OC box I) that contributes to tissue-specific transcription. In this study, we demonstrate that the CCAAT displacement protein (CDP), a transcription factor related to the ...

He’S The Top Sports Marketer In 1,000 Years, Rick Burton

Sport Management

No abstract provided.

Faculty And Student Perceptions Of Effective Clinical Teachers, Patricia Frontczak

Masters Theses

The purpose of this study was to identify ADN faculty and ADN student perceptions of the most effective clinical teaching characteristics (ECTC). An exploratory, descriptive design was implemented. ADN faculty and ADN students were surveyed using the Clinical Teacher Characteristics Instrument (CTCI). The CTCI consists of 20 characteristics of clinical teachers that are ranked on a five point Likert-type scale according to importance. The collected data were analyzed using descriptive statistics. Significant differences in perceptions of the most ECTC between the two groups were identified by a Mann Whitney U procedure. A t-test was performed to identify differences of perceptions ...

Medical Education Digest, Vol. 1 No. 3 (December 15, 1999), Nova Southeastern University

Medical Education Digest

No abstract provided.

Identification Of The Human Erythrocyte Glucose Transporter (Glut1) Atp Binding Domain: A Dissertation, Kara B. Levine

Morningside Graduate School of Biomedical Sciences Dissertations and Theses

The human erythrocyte glucose transport protein (GLUT1) interacts with, and is regulated by, cytosolic ATP. This study asks the following questions concerning ATP modulation of GLUT1 mediated sugar transport. 1) Which region(s) of GLUT1 form the adenine nucleotide-binding domain? 2) What factors influence ATP modulation of sugar transport? 3) Is ATP interaction with GLUT1 sufficient for sugar transport regulation?

The first question was addressed through peptide mapping, n-terminal sequencing, and alanine scanning mutagenesis of GLUT1 using [³²P]-azidoATP, a photoactivatable ATP analog. We then used a combination of transport measurements and photolabeling strategies to examine how glycolytic intermediates ...

Implantable Controlled Release Device To Deliver Drugs Directly To An Internal Portion Of The Body, Paul Ashton, Paul A. Pearson

Ophthalmology and Visual Science Faculty Patents

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide, (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, (POBN), and ...

Transcriptional Silencing Elements And Their Binding Factors, Joseph Chappell, Jeffrey D. Newman, Shaohui Yin

Pharmaceutical Sciences Faculty Patents

The invention features an isolated gene silencing regulatory element that includes 5' TACNNTAC 3'. Vectors, transgenic plants and seeds thereof that include such a gene silencing regulatory element are also disclosed. The invention further provides methods of decreasing the transcription of a DNA sequence in a transgenic plant using the isolated gene silencing regulatory element.

Trends. Drug Addictions: National Policy On Illicit Drugs, Ibpp Editor

International Bulletin of Political Psychology

The article discusses the proposed integrating of drug testing and treatment into the various phases of the criminal justice process.

A Study Of Nursing Students And Intrinsic Spirituality, Christine Anderson Madsen

Master's Projects

This paper describes some theoretical perspectives of spirituality, the concepts of spiritual care and spiritual needs, and barriers to providing spiritual care as described in the literature. The two most frequently described barriers are lack of comfort with the topic and lack of education. Because there is so little written about the discussion of spirituality in schools of nursing, a descriptive study using nursing students on the central coast of California was conducted. The Spiritual Involvement and Beliefs Scale (SIBS) was used to measure intrinsic spirituality. This study looked for relationships between the scores on this scale, and the students ...

What's Happening: December 8, 1999, Maine Medical Center

What's Happening

No abstract provided.

Analysis Of Cell Polarity Signaling In C. Elegans: A Dissertation, Christian Ernest Rocheleau

Morningside Graduate School of Biomedical Sciences Dissertations and Theses

During embryonic development of the nematode Caenorhabditis elegans, cell fates are specified by asymmetric segregation of cell fate determinants and via cell-cell signaling events. Specification of the eight-cell stage blastomere E, the endoderm progenitor cell, requires both cell signaling and asymmetric cell division. At the four-cell stage, a polarity-inducing signal from the P₂ cell is required for the EMS cell to divide asymmetrically to produce an anterior daughter MS, and posterior daughter E. In the absence of signal, the EMS cell divides symmetrically to produce two daughters that adopt the MS fate. This thesis describes the identification and analyses ...

Recommendations For Standards Regarding Preclinical Neuroprotective And Restorative Drug Development

Open Access Publications by UMass Chan Authors

The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns about how best to proceed for the future development of such interventions. Preclinical testing of neuroprotective drugs is an important aspect of assessing their therapeutic potential, but guidelines concerning how to perform preclinical development of purported neuroprotective drugs for acute ischemic stroke are lacking. This conference of academicians and industry representatives was convened to suggest such guidelines for the preclinical evaluation of neuroprotective drugs and to recommend to potential clinical investigators the data they should review to reassure themselves that a particular neuroprotective ...

Occupational Therapists' Interests And Attitudes Toward Animal Assisted Therapy As A Treatment Modality, Lori Susan Buckley

FIU Electronic Theses and Dissertations

One hundred seventy-nine occupational therapists (OTs) responded to a survey regarding their interests and attitudes toward animal assisted therapy as a treatment modality. It was found that most of the practitioners would be interested in learning more about animal assisted therapy and most felt it is a valid treatment modality to be used by occupational therapists. Furthermore, the most common answer to the question "why would you not be interested in participating in an AAT program," was "I feel I don't know enough about it". It was also found that therapists' most commonly selected patient goals for AAT were ...

Appendices, Glossary, And Index (Field Manual Of Wildlife Diseases)

Other Publications in Zoonotics and Wildlife Disease

A. Sample specimen history form
B. Sources of wildlife diagnostic assistance in the United States
C. Sources of supplies used for collecting, preserving, and shipping specimens
D. Normal brain cholinesterase activity values
E. Common and scientific names of birds in text
F. Common and scientific names other than birds
G. Chemical names
H. Conversion table

Glossary
Index

REPORT DOCUMENTATION PAGE

Introduction To General Field Procedures (Field Manual Of Wildlife Diseases), J. Christian Franson, Milton Friend, Dale E. Toweill, Robert L. Brownell Jr., Victor F. Nettles, Donald S. Davis, William J. Foreyt

Other Publications in Zoonotics and Wildlife Disease

Section 1 of the Manual provides basic information regarding general field procedures for responding to wildlife disease events. Field biologists provide a critical linkage in disease diagnostic work and greatly affect the outcome of the laboratory efforts by the quality of the materials and information that they provide. The chapters in this section are oriented towards providing guidance that will assist field biologists in gathering the quality of information and specimens that are needed. Readers will find information regarding what to record and how; guidance for specimen collection, preservation, and shipment; and how to apply euthanasia when such actions are ...

Bacterial Diseases (Field Manual Of Wildlife Diseases), Milton Friend

Other Publications in Zoonotics and Wildlife Disease

Diseases caused by bacteria are a more common cause of mortality in wild birds than are those caused by viruses. In addition to infection, some bacteria cause disease as a result of potent toxins that they produce. Bacteria of the genus Clostridium are responsible for more wild bird deaths than are other disease agents. Clostridium botulinum, which causes avian botulism, is primarily a form of food poisoning and it is included within the section on biotoxins (see Chapter 38). Other Clostridium sp. that colonize intestinal tissues produce toxins that cause severe hemorrhaging of the intestine, thus leading to tissue death ...

Fungal Diseases (Field Manual Of Wildlife Diseases), Milton Friend

Other Publications in Zoonotics and Wildlife Disease

Fungi are important causes of disease in wild birds and other species. Three basic types of disease are caused by these agents: mycosis, or the direct invasion of tissues by fungal cells, such as aspergillosis; allergic disease involving the development of a hypersensitivity of the host to fungal antigens; and mycotoxicosis, which results from ingestion of toxic fungal metabolites. Mycosis and allergic disease may occur together, especially when the lung is infected. This section will address only mycosis. Mycotoxicosis is addressed in Section 6, Biotoxins. Allergic disease is not well studied in wild birds and it is beyond the scope ...

Viral Diseases (Field Manual Of Wildlife Diseases), Douglas E. Docherty

Other Publications in Zoonotics and Wildlife Disease

Historically, viral diseases have not been recognized as major causes of illness and death in North American wild birds. Until relatively recently, this may have been due to inadequate technology to culture and identify these organisms. Unlike bacteria, viruses are too small to be seen under the light microscope and they cannot be grown on artificial media. Nevertheless, studies of infectious diseases caused by viruses have often predated discovery of the causative agents by many years as evidenced by smallpox immunizations being used centuries before that virus was identified. The isolations of a tobacco mosaic virus in 1892 and foot ...

Parasites And Parisitic Diseases (Field Manual Of Wildlife Diseases), Rebecca A. Cole, Milton Friend

Other Publications in Zoonotics and Wildlife Disease

Parasitism is an intimate relationship between two different species in which one (parasite) uses the other (host) as its environment from which it derives nourishment. Parasites are a highly diverse group of organisms that have evolved different strategies for infecting their hosts. Some, such as lice and ticks, are found on the external parts of the body (ectoparasites), but most are found internally (endoparasites). Some are microscopic, such as the blood protozoans that cause avian malaria; however, many are macroscopic. Life cycles differ greatly between major types of parasites and are generally classified as direct or indirect (Table 1). Direct ...

Biotoxins (Field Manual Of Wildlife Diseases), Tonie E. Rocke, Milton Friend

Other Publications in Zoonotics and Wildlife Disease

Biotoxins are usually defined as poisons that are produced by and derived from the cells or secretions of living organisms. These natural poisons include some of the most toxic agents known and they are found within a wide variety of life forms. Organisms that produce such toxins are generally classified as being venomous or poisonous. The classification of venomous is usually associated with animal life forms such as poisonous reptiles and insects that have highly developed cellular mechanisms for toxin production and that deliver their toxins during a biting (rattlesnake) or stinging (black widow spider) act. Poisonous organisms are generally ...

Chemical Toxins (Field Manual Of Wildlife Diseases), Milton Friend

Other Publications in Zoonotics and Wildlife Disease

Many kinds of potentially harmful chemicals are found in environments used by wildlife. Some chemicals, such as pesticides and polychlorinated biphenyls (PCBs), are synthetic compounds that may become environmental contaminants through their use and application. Other materials, such as selenium and salt, are natural components of some environments, but contaminants of others. Natural and synthetic materials may cause direct poisoning and death, but they also may have adverse effects on wildlife that impair certain biological systems, such as the reproductive and immune systems. This section provides information about some of the environmental contaminants and natural chemicals that commonly cause avian ...

The Facilitation Of Effective Coping Strategies Used By Women In Early Motherhood - Implications For Antenatal Education, Christine Marie Johnstone

Theses Masters Coursework

This paper explores the effectiveness of coping strategies used by women in early motherhood. The purpose of the study and Swanson's Theory of Caring were used as a framework to organize the data analyzed. The qualitative research literature reviewed particularly, provided insights into the empowerment of women for transition to motherhood. Three themes evolved from current literature. These were: antenatal education, losses and failing. Women-generated solutions were elicited from the literature. These suggested recommendations were in terms of:

• antenatal education

• antenatal education being user friendly

• antenatal education being relevant to counteract feelings of failure.

This treatise recommends philosophical and ...

Developing Augmentative Communication To Support Participation In General Education Classrooms, Michael Mcsheehan, Rae M. Sonnenmeier

Institute on Disability

No abstract provided.

Venous Leg Ulcer Treatment: Why Won't The Patient Comply?, Jill Sparks

Theses Masters Coursework

Community nurses spend much of their time in the treatment and prevention of recurrence of venous leg ulcers. Failure by patients to follow treatment regimes that include compression therapy, diet, exercise and leg elevation is the source of much frustration for community nurses who are quick to label these patients as "non-compliant". Why is it that some patients will adopt health behaviours that are beneficial for the healing of venous leg ulcers and other patients will not? What can community nurses do to encourage participation in the above, self-care activities? A complex relationship between multiple factors that influence patients' decisions ...

Miscellaneous Diseases (Field Manual Of Wildlife Diseases), Milton Friend, Nancy J. Thomas

Other Publications in Zoonotics and Wildlife Disease

The fact that “Nature is far from benign” is clearly evident from the preceding chapters of this Manual. The diseases and other conditions described are the proverbial “tip of the iceberg” relative to the number of specific causes of ill health and death for free-ranging wild birds, but the wild bird health problems described account for most major wild bird disease conditions seen within the United States. However, the full toll from disease involves many other causes of illness and death that individually may cause substantial die-offs. Two examples of these other causes of die-offs are the deaths of Canada ...