Medicine and Health Sciences Commons^™

Nicotine-Induced Effects On Nicotinic Acetylcholine Receptors (Nachrs), Ca2+ And Brain-Derived Neurotrophic Factor (Bdnf) In Stc-1 Cells, Jie Qian, Shobha K. Mummalaneni, Reem M. Alkahtan, Sunila Mahavadi, Karnam S. Murthy, John R. Grider, Vijay Lyall

Physiology and Biophysics Publications and Presentations

In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol. However, at present it is not clear if nAChRs are expressed in enteroendocrine cells other than beta cells of the pancreas and enterochromaffin cells, and if they play a role in the synthesis and release of neurohumoral peptides. Accordingly, we investigated the expression and functional role of nAChRs in enteroendocrine STC-1 cells. Our studies using RT-PCR, qRT-PCR, immunohistochemical and Western blotting techniques demonstrate that STC-1 cells express several α and …

Organizational Behavior Of Rehabilitation Residents In Taiwan: A Cross-Sectional Correlation Study, Kuancheng Chen, Yujen Chen, Chiayi Shen, Chengming Chiu, Yitien Su

Rehabilitation Practice and Science

Most studies on organizational behavior in Taiwan have focused on nurses and general medical staff; however, few studies have focused on rehabilitation residents. We conducted a cross-sectional correlation study on the organizational behavior of 30 rehabilitation residents in Taiwan by administering anonymous questionnaires through mail. The results revealed low continuance commitment scores (p＜.05) among female residents, whereas senior residents showed a high tendency to quit their current jobs. In addition, 19 residents presented type A personality and 11 residents presented type B personality.

The Effect Of Outpatient Physiotherapy After Stroke On Cardiopulmonary Training Goals: The Current Situation In A Single Medical Center, Yichun Lu, Chiachi Huang, Chenliang Chou

Rehabilitation Practice and Science

Study background and objectives: Reduced cardiopulmonary function after stroke has drawn increasing attention. Cardiovascular function and muscle fiber composition change after stroke, leading to a decline in physical fitness. Some studies have also reported decreased maximum oxygen uptake after stroke, which would further reduce patient ability to perform daily life functions, inducing a circle of disability and reduced mobility. Cardiopulmonary rehabilitation after early or late strokes has been found to improve cardiopulmonary function; these improvements are especially noticeable in patients with lower levels of physical activity before their stroke onset. However, traditional rehabilitation programs mostly focus on recovery of limb …

Developed An Interactive Visual Dashboard To Assess The Fall Risk Among Community-Dwelling Elderly, Weichiao Lu, Shuchuan Wu, Hsihsun Su, Chingjen Cang, Tienlung Sun, Chienhua Huang

Rehabilitation Practice and Science

The main purpose of data visualization is to provide an overview of data characteristics. In this study, a data visualization-based interactive exploration environment was developed to assess the risk of falling among community-dwelling elderly adults. The research goal was to enable clinicians to apply their expert knowledge to quickly derive information from the data and analyze the risk of falling. By visualizing the data to derive information, the clinicians were able to analyze preliminary screening results to identify elderly adults at a high risk of falling and subsequently advise them to return to hospital for a comprehensive geriatric assessment. In …

Effect Of Individualized Bladder Rehabilitation Program In Patients With Neurogenic Lower Urinary Tract Dysfunction, A Pilot Study, Peir-Renn Wang, Wei-Che Wang, Sung-Lang Chen, Yu-Hui Huang, Yu-Fen Lai, Hsiu-Chun Yang

Rehabilitation Practice and Science

Objectives: Neurogenic lower urinary tract dysfunction (NLUTD) is one of the major sequelae after spinal cord injury (SCI) and a cause of increased morbidity and mortality in SCI patients. Current treatment strategies for NLUTD include medication, non-invasive conservative management, minimally invasive therapy, and surgical intervention. However, there are no studies regarding non-invasive conservative management that combines pelvic floor muscle (PFM) exercises and electrical stimulation (ES). This study was designed to evaluate the efficacy of individualized bladder rehabilitation programs, which included education on voiding behavior, PFM exercise training combined with electromyography (EMG) biofeedback, and ES (for bladder inhibition or PFM strengthening), …

Neuropsychological Rehabilitation With Prospective Memory Process Training In A Patient With Severe Amnesia After Traumatic Brain Injury: A Casereport, Pin-Hsiu Chen, Ya-Fang Hsu, Wen-Chih Lin, Tai-Ching Wu

Rehabilitation Practice and Science

Patients with severe amnesia frequently experience difficulty in storing and retrieving new information, resulting in prospective memory impairment, one of the main reasons for sustained loss of functioning in daily life. Currently, little literature on the neuropsychological interventions for severe amnesia patients has been published. The present study applied prospective memory process training (PROMPT) in neuropsychological intervention to a patient with severe amnesia caused by traumatic brain injury, and investigated the efficacy of this method. The intervention was administered for 12 months long to a 23-year-old male participant with severe amnesia caused by traumatic brain injury. The intervention was administered …

Deep Vein Thrombosis In An Ambulatory Hemiparetic Stroke Patient Probably Due To Exercise-Related Repetitive Impact: A Casereport, Kun-Chang Lee, Chien-Ting Liu, Pi-Wei Wang, An-Fang Hsiao, Yi-Shiung Horng

Rehabilitation Practice and Science

Deep vein thrombosis (DVT) of the lower extremity is a multifactorial and potentially fatal complication following stroke. However, repetitive impact on the lower extremity is a relatively uncommon risk factor for DVT. We report an ambulatory hemiparetic stroke patient who, without classic DVT risk factors, developed a lower extremity DVT probably due to repetitive impact on the popliteal fossa after the inappropriate use of a seated leg flexion machine. This case can remind physiatrists and therapists of the importance of preventing patients from using non-ergonomic postures during training sessions.

Factors Associated With Nasogastric Tube Removal In Patients With Post-Stroke Dysphagia Following Acute/Subacute Stroke, Hsin-Chiao Wen, Hao-Wei Tang, Chang-Ren Peng, Kuan-Lin Chen, Ching-Min Hsiao, Chung-Che Lin

Rehabilitation Practice and Science

Purpose: Stroke is a common cause of dysphagia, and persistent post-stroke dysphagia is associated with a poor outcome and an increased mortality rate. Nasogastric tubes (NGTs) are frequently the recommended method for the safe administration of nutrition and hydration in stroke patients. However, prolonged use of NGTs can lead to complications, such as gastro-esophageal reflux and aspiration pneumonia. The purpose of this study was to determine the factors associated with NGT removal in patients with post-stroke dysphagia. Method: This was a retrospective study. We recruited patients with post-stroke dysphagia who had received feeding either partially or totally via NGT and …

Correlation Between Sternocleidomastoid Muscle Stiffness After Radiation Therapy And Quality Of Life In Patients With Head And Neck Cancer, Shih-Chung Chang, Peir-Renn Wang, Hsien-Chun Tseng, Su-Ju Tsai, Yu-Li Cheng

Rehabilitation Practice and Science

Objective: Radiation-induced fibrosis after radiation treatment frequently results in neck and shoulder pain/dysfunction, trismus, dysphagia, muscle stiffness and lower health-related quality of life (HRQOL) in patients with head and neck (H&N) cancer. Here, we access the correlation between neck muscle stiffness after radiation therapy and HRQOL, and the effect of rehabilitation on muscle stiffness and HRQOL. Method: We used real-time sonoelastography to evaluate sternocleidomastoid muscle (SCM) stiffness after radiation therapy. We used the EORTC QLQ-30 and EORTCQLQ H&N35 to evaluate the HRQOL of H&N cancer patients. Each participant received real-time sonoelastography and an HRQOL evaluation twice with the course of …

Combining Eldercare Technology With Interactive Arts Environment, Alice M. K. Wong, Chung-Chih Lin, Su-Chu Hsu, Chia-Ying Chung, Yin-Chou Lin, Pei-Chi Huang, Chih-Kuang Chen

Rehabilitation Practice and Science

Background and Purpose: People who age successfully should exhibit healthy function in physiological, psychological, and social domains. They should demonstrate independence in daily living, proper cognitive function without depression, and the ability to participate in community activities, as well as maintain favorable interpersonal relationships with others to enjoy living. Material and Methods: In this study, for promoting the successful aging of elderly residents of Chang Gung Silver Village, we developed six smart devices that involve combining an interactive art environment with exergames and health administration: ＂Interactive Wall with Life Memories＂, ＂Interactive Floor Kick and Play＂, ＂Interactive Table with Musical Pots＂, …

Developing And Validating A Screening Scale For Assessing Preschool Children's Motor Development: A Preliminary Study, Chia-Chi Wang, Chien-Ju Chang, Po-Hsi Chen, Wen-Yu Liu, Chia-Ling Chen, Chih-Chien Tsai, Ren-Huei Fu, Li-Tuan Chou, Shih-Ming Chu

Rehabilitation Practice and Science

Background: Questionnaires available for screening the motor development of preschool children in Taiwan are few. Therefore, this study developed a Developmental Motor Screening Scale for Preschool Children (DMSSPC), and it exhibits high reliability and validity. Methods: The DMSSPC was developed on the basis of an expert meeting and a literature reviewarticle of assessment tools and questionnaires for screening motor development. After the meeting, subscales of the fine and gross motor scales of the DMSSPC were determined. The fine motor scale comprised grasp, manipulation, and visual motor integration subscales, whereas the gross motor scale contained stationary, locomotion, and body coordination subscales. …

The Effect Of Low Level Laser Therapy With Cluster Probe On Myofascial Trigger Spots In A Rabbit Model: A Case-Controlled Trial, Yi-Hsuan Lai, He-Yu Tsai, Shih-Yang Huang, Wei-Chi Hsieh, Chien-Min Chen, Chang-Zern Hong, Hung-Chih Hsu, Kai-Hua Chen

Rehabilitation Practice and Science

Objective: This study investigated the effect of cluster probe low level laser therapy (LLLT) with a continuous wavelength of 830 nm or 980 nm on the myofascial trigger spot (MTrS) in rabbit skeletal muscle, an animal model of myofascial pain syndrome (MPS). Methods: Thirty-seven New Zealand rabbits with MTrSs in the thigh muscle were divided into three groups and were given placebo treatment (0 J/leg/day), 830 nm LLLT (6 J/leg/day), and 980 nm LLLT (6 J/leg/day), respectively, for 5 days. Electromyographic studies were used to evaluate the endplate noise (EPN) prevalence in each MTrS before treatment, on the first and …

Simultaneous Bilateral Intracerebral Hemorrhage In A Case Of Wegener's Granulomatosis: A Casereport And Literature Reviewarticle, Yu-Jen Chen, Ho-Fai Wong, Chih-Chi Chen, Chia-Ling Chen, Chia-Ying Chung

Rehabilitation Practice and Science

Background: Simultaneous multiple intracerebral hemorrhages (ICHs) are rare and their underlying mechanisms are unknown. Reported etiologies include hypertension, vasculitis, cerebral amyloid angiopathy, venous sinus thrombosis, coagulopathy, and intracranial vascular anomalies. Granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) is a necrotizing granulomatous vasculitis affecting small- and medium-sized vessels of the respiratory tract and kidneys. The reported frequency of central nervous system (CNS) involvement in GPA is 0%-16.4%. Case presentation: A 34-year-old man with hypertension presented with a sudden loss of consciousness and weakness in the right limbs. Brain computed tomography (CT) showed a left basal ganglion hemorrhage and right basal ganglion infarction …

Relationship Between Perioperative Risk And Cardio-Respiratory Fitness After Coronary Artery Bypass Grafting, Cheng-Ming Chiu, Kuan-Cheng Chen, Chia-To Wang, Chen-Liang Chou

Rehabilitation Practice and Science

Introduction and objectives: The European System for Cardiac Operative Risk Evaluation II (euroSCORE II) is a validated model for predicting perioperative mortality after cardiac surgery. The role of cardio-respiratory fitness (CRF), expressed as peak metabolic equivalents (METs), as a predictor of long-term survival in patients who have previously undergone coronary artery bypass grafting (CABG) is well established. However, the correlation between perioperative risk and CRF has not been evaluated. The aim of this study was to investigate the relationship between perioperative risk and CRF in patients after CABG. Methods: Patients who underwent CABG from January 2012 through December 2013 at …

A Trial Of Wound Irrigation In The Initial Management Of Open Fracture Wounds, Mohit Bhandari, Kyle J. Jeray, Brad A. Petrisor, P. J. Devereaux, Diane Heels-Ansdell, Emil H. Schemitsch, Jeff Anglen, Gregory J. Della Rocca, Clifford Jones, Hans Kreder, Susan Liew, Paula Mckay, Steven Papp, Parag Sancheti, Sheila Sprague, Trevor B. Stone, Xin Sun, Stephanie L. Tanner, Paul Tornetta, Ted Tufescu, Stephen Walter, Gordon H. Guyatt

Bone and Joint Institute

Copyright © 2015 Massachusetts Medical Society. BACKGROUND The management of open fractures requires wound irrigation and dridement to remove contaminants, but the effectiveness of various pressures and solutions for irrigation remains controversial. We investigated the effects of castile soap versus normal saline irrigation delivered by means of high, low, or very low irrigation pressure. METHODS In this study with a 2-by-3 factorial design, conducted at 41 clinical centers, we randomly assigned patients who had an open fracture of an extremity to undergo irrigation with one of three irrigation pressures (high pressure [>20 psi], low pressure [5 to 10 psi], …

Trombositopenia Refrakter, Andhika Rachman

Jurnal Penyakit Dalam Indonesia

Tranfusi trombosit berperan penting dalam manajemen kasus trombositopenia akibat kelainan hematologi dan onkologi. Namun, hampir sebagian besar pasien yang mendapatkan tranfusi trombosit berulang, sering mengalami kejadian tranfusi trombosit refrakter baik akibat faktor imunologi maupun non imunologi.

Perbedaan Pola Sirkadian Tekanan Darah Pada Pasien Penyakit Ginjal Kronik Pra Dan Pascatransplantasi Ginjal Di Rscm, Marihot Tambunan, Endang Susalit, Dharmeizar Dharmeizar, Cleopas Martin Rumende

Jurnal Penyakit Dalam Indonesia

Pendahuluan: Meningkatnya tekanan darah (TD) 24 jam dan nondipper merupakan faktor risiko morbiditas dan mortalitas kardiovaskular. Prevalensi hipertensi dan nondipper pada Penyakit Ginjal Kronik Stadium 5 dalam Terapi Dialisis (PGK 5D) masih sangat tinggi. Transplantasi ginjal akan memperbaiki TD dan nondipper. Namun demikian, satu bulan pasca transplantasi ginjal, kebutuhan dosis obat imunosupresan masih cukup tinggi yang dapat mengakibatkan hambatan penurunan TD. Perlu dilakukan studi untuk mengetahui seberapa dini perubahan pola sikardian, sehingga dapat dijadikan pertimbangan penatalaksanaan hipertensi yang lebih tepat pada pasien PGK 5D pra dan pasca transplantasi ginjal.

Metode: Studi Pre experimental dengan before and after design …

Faktor-Faktor Yang Berhubungan Dengan Kenaikan Cd4 Pada Pasien Hiv Yang Mendapat Highly Active Antiretroviral Therapy Dalam 6 Bulan Pertama, Indria Yogani, Teguh Harjono Karyadi, Anna Uyainah, Sukamto Koesnoe

Jurnal Penyakit Dalam Indonesia

Pendahuluan: HIV adalah infeksi yang menyerang sistem kekebalan tubuh dengan CD4 sebagai sel targetnya. Ditemukannya Highly Active Antiretroviral Therapy (HAART) diharapkan mampu menurunkan angka morbiditas dan mortalitas HIV. Namun, kenaikan CD4 tidak sama untuk setiap pasien serta terdapat faktor lain yang berhubungan dengan kenaikan CD4 pada pasien HIV.

Metode: Studi kohort retrospektif dilakukan pada pasien HIV rawat jalan di Unit Pelayanan Terpadu HIV Rumah Sakit dr. Cipto Mangunkusumo (RSCM) Jakarta selama Mei- Juni 2014.. Data penelitian didapatkan dari rekam medis selama Januari 2004-Desember 2013. Analisis data menggunakan program SPSS dengan uji Mann Whitney, uji Chi Square atau Fisher …

Faktor-Faktor Yang Berperan Terhadap Terjadinya Lipodistrofi Pada Pasien Hiv Yang Mendapatkan Terapi Antiretroviral Lini Pertama, Ratu Ratih Kusumayanti, Evy Yunihastuti, Dyah Purnamasari, F Witjaksono, Esthika Dewiasty

Jurnal Penyakit Dalam Indonesia

Pendahuluan. Seiring dengan perkembangan antiretroviral, harapan hidup pasien HIV terus meningkat namun menjadi rentan terhadap efek samping pengobatan. Salah satu efek samping pengobatan adalah sindrom lipodistrofi, meliputi lipoatrofi, lipohipertrofi, atau gabungan keduanya. Faktor risiko yang dikaitkan dengan lipodistrofi pada HIV adalah usia, jenis kelamin, lama terapi antiretroviral, CD4 awal, Stadium HIV, dan pemakaian Stavudin. Belum ada publikasi di Indonesia yang meneliti kejadian lipodistrofi pada populasi pasien HIV yang mendapat terapi ARV lini pertama serta faktor-faktor yang memengaruhinya. Berdasarkan hal tersebut, penelitian ini dilakukan untuk mengetahui kejadian lipodistrofi pada pasien HIV dalam terapi ARV lini pertama berbasis Stavudin dan Zidovudin …

Pengaruh Pemberian N-Acetylcysteine Oral Terhadap High Sensitivity C Reactive Protein (Hs-Crp) Pada Pasien Hemodialisis Kronis, Ratih Tri Kusuma Dewi, Parlindungan Siregar, Idrus Alwi, Cleopas Martin Rumende

Jurnal Penyakit Dalam Indonesia

Pendahuluan. Inflamasi dan stres oksidatif merupakan faktor risiko penyakit kardiovaskuler pada pasien penyakit ginjal kronis yang menjalani hemodialisis. Pasien hemodialisis kronis akan mengalami peningkatan kadar Hs-CRP. Hs-CRP merupakan marker inflamasi yang telah terbukti pada beberapa penelitian bermanfaat dalam memprediksi cardiovascular event. Pemberian N-Acetylcysteine (NAC) oral dapat digunakan sebagai strategi untuk menurunkan proses inflamasi yaitu disfungsi endotel dan stress oksidatif yang berperan pada atherosclerosis pada pasien hemodialsis. Pemberian NAC ini diharapkan dapat menurunkan angka morbiditas dan mortalitas karena penyakit kardiovaskuler.

Metode. Penelitian eksperimen dengan Randomized Double Blind Controlled Trial pada 65 pasien hemodialisis kronis yang memenuhi kriteria inklusi di …

Pendekatan Diagnosis Dan Tatalaksana Endokarditis Infektif Dengan Komplikasi Emboli Septik Pulmoner Pada Pasien Hemodialisis Kronik, Jeremia Immanuel Siregar, Imelda Maria Loho, Idrus Alwi

Jurnal Penyakit Dalam Indonesia

Pendahuluan. Endokarditis infektif (EI) pada pasien hemodialisis (HD) merupakan salah satu contoh EI yang terkait dengan perawatan kesehatan dan menjadi penyebab kematian kedua pada pasien HD setelah penyakit kardiovaskuler. Penggunaan kateter intravaskuler sebagai akses HD meningkatkan risiko kejadian bakteremia sebesar sepuluh kali lipat serta infeksi “metastatik” seperti EI dan emboli septik pulmoner sebesar 10-40%. Ilustrasi Kasus. Seorang laki-laki berusia 35 tahun datang dengan keluhan dyspnea d’effort, orthopnea, dan post-nocturnal dyspnea, disertai batuk dengan bercak darah dan demam tinggi sejak lima hari sebelum masuk rumah sakit. Pasien menjalani HD kronik selama 15 bulan dengan menggunakan catheter double-lumen (CDL). Dari pemeriksaan fisik …

Pengembangan Model Latihan Relaksasi Yochiho Bagi Penderita Diabetes Mellitus Tipe 2, Ratna Endi Yanuita, Bm. Wara Kushartanti

Jurnal Keolahragaan

Penelitian ini bertujuan untuk menghasilkan model latihan relaksasi gabungan dari latihan Yoga, Tai Chi, dan Makko Ho (YOCHIHO) bagi penderita diabetes mellitus tipe 2. Diharapkan latihan relaksasi ini dapat menaikkan relaksasi otot, memperbaiki kapasitas fisik, dan mengelola kadar glukosa darah pada penderita diabetes mellitus tipe 2. Penelitian pengembangan ini mengadaptasi langkah-langkah Borg & Gall, sebagai berikut: (1) studi pendahuluan, (2) perencanaan, (3) mengembangkan produk awal (draf produk), (4) validasi ahli, (5) revisi produk I, (6) uji coba skala kecil, (7) revisi produk II, (8) uji coba skala besar, (9) revisi produk final, dan (10) Produk hasil pengembangan. Dalam …

Perbedaan Perubahan Tekanan Darah Dan Denyut Jantung Pada Berbagai Intensitas Latihan Atlet Balap Sepeda, Mirza Hapsari Sakti Titis Penggalih, Marina Hardiyanti, Fadhila Ika Sani

Jurnal Keolahragaan

Latihan pada cabang bersepeda memperhatikan intensitas dengan salah satu parameternya denyut jantung. Penelitian ini bertujuan mengetahui perbedaan perubahan tekanan darah dan denyut jantung pada berbagai intensitas latihan atlet balap sepeda. Populasi dalam penelitian ini adalah 11 atlet balap sepeda Pegasus Continental Cycling Team selama periode pengamatan April-Juni 2015. Teknik sampling menggunakan total sampling. Analisis data menggunakan uji One Way Anova. F hitung denyut jantung dengan intensitas latihan 3,695 ‰¥ F tabel 3,316 dengan probabilitas 0,037 < 0,05 menunjukkan ada perbedaan signifikan antara perubahan denyut jantung dengan berbagai intensitas latihan. F hitung tekanan sistol dengan intensitas latihan 2,372 ‰¤ F tabel 3,316 dengan probabilitas 0,111 > 0,05 menunjukkan tidak ada perbedaan signifikan antara perubahan tekanan sistol pada berbagai intensitas latihan. F hitung tekanan diastol dengan intensitas latihan 0,852 ‰¤ F …

Hubungan Antibodi Anti Trombosit Terhadap Respon Transfusi Trombosit Pada Pasien Hemato-Onkologi Yang Mendapatkan Multitransfusi Trombosit Di Rs Dr. Cipto Mangunkusomo, Anna Mira Lubis, Aru W. Sudoyo, Shufrie Effendy, Tb Djumhana, Kuntjoro Harimurti

Jurnal Penyakit Dalam Indonesia

Pendahuluan: Multitransfusi donor random dan paparan terhadap konsentrat trombosit yang termasuk non-leukocyte depleted diketahui sebagai faktor risiko terjadinya alloimunisasi (HLA dan HPA) yang dapat menjadi salah satu penyebab kegagalan transfusi. Oleh karena itu, perlu dilakukan penelitian mengenai hubungan antibodi anti trombosit tersebut dengan kegagalan respon transfusi trombosit pada pasien hemato-onkologi sehingga dapat dilakukan metode seleksi donor dan crossmatching trombosit donor dan resipien.

Metode: Studi observasional dilakukan pada pasien hemato-onkologi dewasa yang mendapatkan multitransfusi trombosit di Rumah Sakit dr Cipto Mangunkusumo (RSCM) Jakarta. Pengamatan dilakukan pada respon transfusi dengan mengukur corrected count increment (CCI) 1 jam post transfusi dengan …

Pengaruh Depresi Terhadap Perbaikan Infeksi Ulkus Kaki Diabetik, Arshita Auliana, Em Yunir, Rudi Putranto, Pringgodigdo Nugroho

Jurnal Penyakit Dalam Indonesia

Pendahuluan. Pasien Diabetes Melitus (DM) dengan ulkus kaki lebih banyak yang mengalami depresi dan memiliki kualitas hidup yang buruk. Dalam tatalaksana ulkus kaki diabetik perlu diperhatikan faktor psikososial karena diperkirakan dapat mempengaruhi penyembuhan luka melalui induksi gangguan keseimbangan neuroendokrin-imun. Penelitian ini bertujuan untuk mengetahui pengaruh depresi terhadap proses perbaikan infeksi ulkus kaki diabetik, serta tingkat depresi pada pasien ulkus kaki diabetik yang dirawat inap.

Metode. Studi kohort prospektif dilakukan pada 95 pasien ulkus kaki diabetik terinfeksi yang dirawat di RSCM dan RS jejaring pada Maret-Oktober 2014. Subjek dibagi ke dalam dua kelompok yaitu kelompok depresi dan kelompok tidak …

Rapamycin Rescues Vascular, Metabolic And Learning Deficits In Apolipoprotein E4 Transgenic Mice With Pre-Symptomatic Alzheimer’S Disease, Ai-Ling Lin, Jordan B. Jahrling, Wei Zhang, Nicholas Derosa, Vikas Bakshi, Peter Romero, Veronica Galvan, Arlan Richardson

Sanders-Brown Center on Aging Faculty Publications

Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's disease. Brain vascular and metabolic deficits can occur in cognitively normal apolipoprotein E ɛ4 carriers decades before the onset of Alzheimer's disease. The goal of this study was to determine whether early intervention using rapamycin could restore neurovascular and neurometabolic functions, and thus impede pathological progression of Alzheimer's disease-like symptoms in pre-symptomatic Apolipoprotein E ɛ4 transgenic mice. Using in vivo, multimodal neuroimaging, we found that apolipoprotein E ɛ4 mice treated with rapamycin had restored cerebral blood flow, blood–brain barrier integrity and glucose metabolism, compared …

Suppression Of F1 Male-Specific Lethality In Caenorhabditis Hybrids By Cbr-Him-8, Vaishnavi Ragavapuram, Emily Elaine King, Scott Everet Baird

Biological Sciences Faculty Publications

Haldane's Rule and Darwin's Corollary to Haldane's Rule are the observations that heterogametic F1 hybrids frequently are less fit than their homogametic siblings and that asymmetric results often are obtained from reciprocal hybrid crosses. In Caenorhabditis, Haldane's Rule and Darwin's Corollary have been observed in several hybrid crosses, including crosses of Caenorhabditis briggsae and Caenorhabditis nigoni. Fertile F1 females are obtained from reciprocal crosses. However, F1 males obtained from C. nigoni mothers are sterile and F1 males obtained from C. briggsae die during embryogenesis. We have identified cbr-him-8 as a recessive maternal-effect suppressor of F1 hybrid male-specific lethality …

Recovery Of Oral Intake Function In Elderly Patients With First-Ever Acute Ischemic Stroke, Ya-Fang Hsu, Wen-Chih Lin, Ching-I Hu, Mei-Ju Ko, Chia-Yu Chang, Hing-Man Wu, Willy Chou

Rehabilitation Practice and Science

Introduction and Objective: The effects of aging on swallowing are particularly evident in elderly adults who are ill. Previous studies have reported that prolonged nasogastric tube (NGT) feeding in patients who have had a stroke increases the risk of pneumonia and mortality. However, few studies have investigated the recovery of oral intake function and the factors regarding NGT removal in patients with poststroke dysphagia. In the present study, we investigated the differences in oral intake function between elderly (age: ≥65 y) and nonelderly patients with first-ever acute ischemic stroke. Methods: In this retrospective study, we reviewarticleed the medical charts of …

Applying The Pzb Model In Evaluating The Service Quality Of Pediatric Rehabilitation, I-Hsiu Liou, Shu-Fen Sun, Chiao-Wen Hwang, Yin-Han Chen, Yu-Hsuan Lin, Min-Hui Li, Jue-Long Wang

Rehabilitation Practice and Science

背景：在兒童復健領域的文獻，鮮少有醫療品質之研究。除了接受復健醫療的兒童，家長參與復健因而會介入影響醫療服務提供者，家長的觀感與需求值得受到重視。目的：本研究以PZB服務品質缺口模式為基礎來分析病患對所接受醫療服務的期望與滿意度之落差，此落差即為醫療服務品質。方法：本研究工具為一結構式問卷，共25題，具有良好之信效度，改編自22題的SERVQUAL量表，內容包括五個構面，分別為（1）有形性（2）可靠性（3）反應性（4）確實性（5）關懷性。此研究共74位家長及10位治療師參與。治療師與家長的期望認知以單因子變異數分析進行，家長的期望分數與滿意度落差以配對-t檢定進行。結果：問卷回收率為100%。量表內容效度指標（contentvali dityindex）為0.93，量表的Cronbach's α係數為0.96，具高信度。本研究結果顯示治療師與家長在五個構面的整體期望與滿意度並無顯著組間差異，但組內整體期望與滿意度間均有顯著落差。家長特質分析顯示年齡與教育程度會影響期望與滿意度間之落差。家長重視的面向是治療室環境清潔、希望能在承諾時間內進行復健治療、治療師有足夠專業知識與經驗、可以了解兒童個別需求。本院目前迫切需改善的項目為充實治療室設備並維持環境清潔，在排定治療時間內根據病患需求提供個別化的復健課程，以提升本院兒童復健醫療品質。結論：此研究提供小兒復健醫療品質一個可以利用的評估方式。未來定期運用SERVQUAL可以作為醫療品質之監測。亦可在不同醫院以此工具評估比較醫院間醫療品質之差異。

The Utility Of Semmes-Weinstein Monofilament Test In Detecting Carpal Tunnel Syndrome With Clinical Stage, Nerve Conduction Study, And Sonography Correlations, Lin-Yi Wang, Jyun-Ying Li, Yu-Chi Huang, Mei-Yun Liaw, Tsung-Hsun Yang, Yi-Jung Hsin, Willie Lee, Jui-Kun Chang, Ya-Ping Pong

Rehabilitation Practice and Science

Background and purpose: Nerve conduction study (NCS) and ultrasonography (US) are used to support the diagnosis of carpal tunnel syndrome (CTS). The ability of the Semmes-Weinstein monofilament test (SWMT), a sensibility threshold test, to detect CTS, and its relationship to clinical severity, NCS, and US, remain controversial. We conducted this study to address this controversy. Method: Thirty-three patients presenting with typical symptoms and signs of CTS and 20 normal subjects were enrolled. SWMT on the index finger, NCS, and US of the cross-sectional area of the median nerve at the pisiform level (PCSA) were performed. Receiver operating characteristic (ROC) curves …