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Articles 1 - 30 of 4942

Full-Text Articles in Medicine and Health Sciences

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) Infection By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh Jan 2024

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) Infection By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh

Auctus: The Journal of Undergraduate Research and Creative Scholarship

Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing …


Improving Medication-Enhanced Psychotherapy Options For Ptsd: The Potential Of Oxytocin As A Treatment For Hypervigilance In Women With A History Of Childhood Sexual Abuse And Related Ptsd, Elianna Bavuso Jan 2024

Improving Medication-Enhanced Psychotherapy Options For Ptsd: The Potential Of Oxytocin As A Treatment For Hypervigilance In Women With A History Of Childhood Sexual Abuse And Related Ptsd, Elianna Bavuso

Auctus: The Journal of Undergraduate Research and Creative Scholarship

Childhood sexual abuse (CSA) is a notable public health concern, affecting a significant proportion of girls in high-income countries. A considerable number of CSA survivors develop Post-Traumatic Stress Disorder (PTSD) by adolescence, which is often considered to be a lifelong disorder with severe emotional and social consequences. Women with CSA-related PTSD display hypervigilance, which is characterized by significantly increased fear network activity and poor top-down control over the amygdala. This meta-analysis examines the potential of intranasal oxytocin (OT) as a treatment for hypervigilance symptoms in women with CSA-related PTSD. The evidence reviewed suggests that intranasal oxytocin can help normalize the …


A Three-Dimensional In Vitro Model Of Disease That Improves Preclinical Research By Incorporating Genetic Diversity And Increasing Physiological Accuracy, Akash Jagdeesh Jan 2024

A Three-Dimensional In Vitro Model Of Disease That Improves Preclinical Research By Incorporating Genetic Diversity And Increasing Physiological Accuracy, Akash Jagdeesh

Auctus: The Journal of Undergraduate Research and Creative Scholarship

Biomedical research is essential for the discovery of new medications and treatments, and is built upon the cooperation of preclinical (in vitro/vivo) research and clinical trials. However, 85% of treatments successful in vitro/vivo fail in clinical trials, suggesting that in vitro models are poor indicators of clinical success. The issue lies in conventional “two-dimensional” in vitro models containing genetically identical cells grown on a flat plate, which lack the variety of cell types and cooperation/structure found in real tissue. Moreover, 2D in vitro models do not simulate humans’ genotypic variability, which affects both pathophysiology and treatment effectiveness. In contrast, 3D …


Determining Effective Treatment Regimens For Breast Cancer Using Combined Immunotherapy And Chemotherapy In Vivo, Akhila Kunuthuru Jan 2024

Determining Effective Treatment Regimens For Breast Cancer Using Combined Immunotherapy And Chemotherapy In Vivo, Akhila Kunuthuru

Auctus: The Journal of Undergraduate Research and Creative Scholarship

Breast cancer has the highest incidence rate of all cancers globally in women, and those of African descent, especially West African females, face higher rates of triple-negative breast cancer (TNBC), a more aggressive form of breast cancer. Immunotherapy for breast cancer is a relatively new treatment option, and research is ongoing to identify the best combination treatments for increasing survival of those diagnosed with TNBC. Eganelisib (IPI-549: a PI3K-gamma inhibitor that works to shift M2 macrophages to M1 to augment T cell function) with other combinatory treatments has shown promising results in reducing tumor growth and increasing survival in mice. …


Bulletin Of The Virginia State Dental Association (Vol. 38, No. 3, 1961) Sep 2023

Bulletin Of The Virginia State Dental Association (Vol. 38, No. 3, 1961)

Bulletin of the Virginia State Dental Association

No abstract provided.


Bulletin Of The Virginia State Dental Association (Vol. 38, No. 1, 1961) Sep 2023

Bulletin Of The Virginia State Dental Association (Vol. 38, No. 1, 1961)

Bulletin of the Virginia State Dental Association

No abstract provided.


Bulletin Of The Virginia State Dental Association (Vol. 38, No. 2, 1961) Aug 2023

Bulletin Of The Virginia State Dental Association (Vol. 38, No. 2, 1961)

Bulletin of the Virginia State Dental Association

No abstract provided.


Understanding Neutrophil Dynamics During Covid-19 Infection, Quiyana M. Murphy May 2023

Understanding Neutrophil Dynamics During Covid-19 Infection, Quiyana M. Murphy

Biology and Medicine Through Mathematics Conference

No abstract provided.


An Ode Model For Investigating The Sleep-Pain Relationship In Sickle Cell Disease, Quindel Jones, Angela M. Reynolds, Cecelia Valrie, Reginald Mcgee, Rebecca Segal May 2023

An Ode Model For Investigating The Sleep-Pain Relationship In Sickle Cell Disease, Quindel Jones, Angela M. Reynolds, Cecelia Valrie, Reginald Mcgee, Rebecca Segal

Biology and Medicine Through Mathematics Conference

No abstract provided.


Stochastic Gradient Descent Method For A Parameter Identification Problem In Elasticity Imaging, Basca Jadamba May 2023

Stochastic Gradient Descent Method For A Parameter Identification Problem In Elasticity Imaging, Basca Jadamba

Biology and Medicine Through Mathematics Conference

No abstract provided.


Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu May 2023

Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu

Biology and Medicine Through Mathematics Conference

No abstract provided.


The Mandelbrot Set For Networks, Templates And Mutated Systems, Anca R. Radulescu May 2023

The Mandelbrot Set For Networks, Templates And Mutated Systems, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.


Intermittent Synchronization In Gamma-Band Neural Oscillations, Anh Nguyen, Leonid L. Rubchinsky May 2023

Intermittent Synchronization In Gamma-Band Neural Oscillations, Anh Nguyen, Leonid L. Rubchinsky

Biology and Medicine Through Mathematics Conference

No abstract provided.


Evaluating A Temperature-Dependent Mosquito Population Model, Morgan H. Jackson, Elizabet Estallo, Cheng Ly, Michael Robert May 2023

Evaluating A Temperature-Dependent Mosquito Population Model, Morgan H. Jackson, Elizabet Estallo, Cheng Ly, Michael Robert

Biology and Medicine Through Mathematics Conference

No abstract provided.


Coffee Break, Coffee May 2023

Coffee Break, Coffee

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modelling The Ability Of Mass Drug Administration To Interrupt Soil-Transmitted Helminth Transmission: Community-Based Deworming In Kenya As A Case Study, Stacey Smith? May 2023

Modelling The Ability Of Mass Drug Administration To Interrupt Soil-Transmitted Helminth Transmission: Community-Based Deworming In Kenya As A Case Study, Stacey Smith?

Biology and Medicine Through Mathematics Conference

No abstract provided.


Lunch Provided, Lunch May 2023

Lunch Provided, Lunch

Biology and Medicine Through Mathematics Conference

No abstract provided.


Analytical Approach For Monitoring The Behavior Of Patients With Pancreatic Adenocarcinoma At Different Stages As A Function Of Time, Aditya Chakaborty Dr, Chris P. Tsokos Dr May 2023

Analytical Approach For Monitoring The Behavior Of Patients With Pancreatic Adenocarcinoma At Different Stages As A Function Of Time, Aditya Chakaborty Dr, Chris P. Tsokos Dr

Biology and Medicine Through Mathematics Conference

No abstract provided.


Studying The Effect Of Western Diet On Atherosclerosis Risk Factors, Eric L. Scott May 2023

Studying The Effect Of Western Diet On Atherosclerosis Risk Factors, Eric L. Scott

Biology and Medicine Through Mathematics Conference

No abstract provided.


A Novel Family Of Chain Binomial Models To Investigate Correlated Vaccination And Infection Rates In Sveirs Epidemic Dynamics, Divine Wanduku May 2023

A Novel Family Of Chain Binomial Models To Investigate Correlated Vaccination And Infection Rates In Sveirs Epidemic Dynamics, Divine Wanduku

Biology and Medicine Through Mathematics Conference

No abstract provided.


Parameter Estimation For Covid-19 Svird Model Using Predictor-Corrector Algorithm, Alejandra D. Herrera Reyes, Susan Rogowski, Diana White, Alexandra B. Smirnova, Ruiyan Luo, Yena Kim May 2023

Parameter Estimation For Covid-19 Svird Model Using Predictor-Corrector Algorithm, Alejandra D. Herrera Reyes, Susan Rogowski, Diana White, Alexandra B. Smirnova, Ruiyan Luo, Yena Kim

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling The Immune Response To Immunotherapy And Triple Negative Breast Cancer In Mice, Dayton J. Syme, Angelica Davenport, Yun Lu, Anna G. Sorace, Nicholas G. Cogan May 2023

Modeling The Immune Response To Immunotherapy And Triple Negative Breast Cancer In Mice, Dayton J. Syme, Angelica Davenport, Yun Lu, Anna G. Sorace, Nicholas G. Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Coffee Break And Breakout Discussions, Coffee May 2023

Coffee Break And Breakout Discussions, Coffee

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling Hiv With Partnership Models, Kathleen Hoffman May 2023

Modeling Hiv With Partnership Models, Kathleen Hoffman

Biology and Medicine Through Mathematics Conference

No abstract provided.


Incorporating Interventions To An Extended Seird Model With Vaccination: Application To Covid-19 In Qatar, Elizabeth B. Amona May 2023

Incorporating Interventions To An Extended Seird Model With Vaccination: Application To Covid-19 In Qatar, Elizabeth B. Amona

Biology and Medicine Through Mathematics Conference

No abstract provided.


Generalized Differential Equation Models For Disease Interventions: A Novel Approach For Predicting Sexually Transmitted Disease Outbreaks, Scott Greenhalgh May 2023

Generalized Differential Equation Models For Disease Interventions: A Novel Approach For Predicting Sexually Transmitted Disease Outbreaks, Scott Greenhalgh

Biology and Medicine Through Mathematics Conference

No abstract provided.


Relative Efficacy Of Resource Constrained Forward And Backward Contact Tracing In An Open Population, Nicholas Roberts May 2023

Relative Efficacy Of Resource Constrained Forward And Backward Contact Tracing In An Open Population, Nicholas Roberts

Biology and Medicine Through Mathematics Conference

No abstract provided.


Exploration Of Differential Equation Models For Phage-Bacteria Population Dynamics, John Lawrence D. Palacios, Rebecca Segal May 2023

Exploration Of Differential Equation Models For Phage-Bacteria Population Dynamics, John Lawrence D. Palacios, Rebecca Segal

Biology and Medicine Through Mathematics Conference

No abstract provided.


Utilizing Optimization Techniques To Build A Patient-Specific 1d Arterial Network For Single Ventricle Patients, Alyssa M. Lapole May 2023

Utilizing Optimization Techniques To Build A Patient-Specific 1d Arterial Network For Single Ventricle Patients, Alyssa M. Lapole

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling Honeymoon And Divorce Effects In Wolbachia Control Trials Of Dengue, Casey P. O'Brien May 2023

Modeling Honeymoon And Divorce Effects In Wolbachia Control Trials Of Dengue, Casey P. O'Brien

Biology and Medicine Through Mathematics Conference

No abstract provided.