Medicine and Health Sciences Commons^™

Volume 38, Index, Canadian Medical Association

Canadian Journal of Surgery

The mission of CJS is to contribute to the effective continuing medical education of Canadian surgical specialists, using innovative techniques when feasible, and to provide surgeons with an effective vehicle for the dissemination of observations in the areas of clinical and basic science research.

Visit the journal website at http://canjsurg.ca/ for more.

Ventricular Remodeling Following Infant-Pediatric Cardiac Transplantation. Does Age At Transplantation Or Size Disparity Matter?, Girish S. Shirali, F Lombano, W L. Beeson, D A. Dyar, N F. Mulla, A Khan, J K. Johnston, R E. Chinnock, S R. Gundry, A J. Razzouk

Manuscripts, Articles, Book Chapters and Other Papers

Early left ventricular (LV) remodeling following pediatric cardiac transplantation has not been described. To identify patterns and determinants of change in left ventricular mass and volume posttransplant, we studied 125 consecutive children who underwent cardiac transplantation between January 1, 1989 and July 31, 1993. Two-dimensional imaging-directed M-mode echocardiograms were studied weekly until 26 weeks post-transplant. LV mass and volume (indexed to BSA1.5) were measured. LV mass index increased until 3 weeks post-transplant, and then decreased. The mean decrement in LV mass index after 8 weeks post-transplant (relative to baseline) was significantly larger in patients with donor-recipient weight ratio > 1 ...

Characterization Of Hybridization Between Synthetic Oligodeoxynucleotides And Rna In Living Cells, Joan C. Ritland Politz, Krishan L. Taneja, Robert H. Singer

Open Access Publications by UMass Chan Authors

Cells internalized synthetic oligonucleotides (oligos) in culture. The hybridization of these molecules to target RNA in the living cell was subsequently detected and characterized after fixation of the cells, with or without previous detergent extraction. Hybridized oligo was distinguished from free oligo in the cell using an in situ reverse transcription technique. This assay exploited the ability of the hybridized oligo to prime synthesis of a specific cDNA strand; unhybridized oligo present in the cell could not act as a primer for reverse transcription. Phosphorothioate and fluorochrome-labeled phosphodiester oligo dT were found to enter cells rapidly and hybridize to poly ...

One-Trial Context Fear Conditioning As A Function Of The Interstimulus Interval, Rick A. Bevins, John J. B. Ayres

Faculty Publications, Department of Psychology

In two experiments, we examined the effects of a wide range of interstimulus intervals (2.5, 15, 45, 120, 135, and 405 sec) on one-trial context fear conditioning with rats. Here, the interstimulus interval (ISI) denotes the time between placement in a conditioning chamber and the onset of a single footshock. On the conditioning day, we observed that the rats’ behavior at the time of shock onset varied systematically across ISI values. On the subsequent test day, we used context-evoked freezing as a measure of context conditioning and found the well-known inverted U-shaped ISI function. We also found that conditioned ...

3 Pertanyaan Umum Tentang Kutil Kelamin.Doc, Denature Indonesia

denature indonesia

Type-Specific Immunity In Hiv-1 Vertically Infected Infants, Cheryl A. Pikora

Morningside Graduate School of Biomedical Sciences Dissertations and Theses

High frequencies of CTL recognizing laboratory strains of HIV-1 are present in HIV-1 infected adults as early as preseroconversion. The presence of HIV-1 specific CTL during primary infection has been correlated with better control of early viremia and a more delayed onset of CD4 lymphocyte loss. Previous experiments in our laboratory have demonstrated that, unlike HIV-1 infected adults, the majority of vertically infected infants lack CTL which recognize laboratory strains of HIV-1 within the first year of life. ADCC antibody responses against laboratory strains of HIV-1 env gene products are also delayed until at least two years of age. As ...

Ua66/14/3 Nursing Pinning Ceremony, Wku Nursing

WKU Archives Records

Pinning ceremony program listing graduates of the WKU Nursing program.

The Impact Of Humor On Energy, Tension, Task Choices, And Attributions: Exploring Hypotheses From Toughness Theory, Richard A. Dienstbier

Faculty Publications, Department of Psychology

Hypotheses derived from toughness theory suggest that nonaggressive humor should lead to increased feelings of energy without influencing tension, to preferences for studying materials that require more effort and energy, and to ratings of mundane laboratory activities as more challenging but not more threatening. Eighty-one college-age men and women were randomly assigned to watch a 12-minute video of Bill Cosby's humor or to watch a nonhumorous control video that analyzed the Cosby comedy routine. The humor condition resulted in significant increases in feelings of energy but not in feelings of tension. The other hypotheses were also confirmed except that ...

2,4-Disulfonyl Phenyl Butyl Nitrone, Its Salt And Their Use As Pharmaceuticals, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.

Wrong Medicine: Doctors, Patients, And Futile Treatment, Charles Weijer

Charles Weijer

No abstract provided.

Phenyl Butyl Nitrone Compositions And Methods For Treatment Of Oxidative Tissue Damage, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, which are active during ischemia in preventing ATP depletion of the cells which predisposes them to subsequent injury during reperfusion, and which are active during reperfusion as oxygen radical scavengers, in a suitable pharmaceutical carrier for systemic or local administration, especially to the CNS, spinal column and eyes. Based on animal studies, the dosage for treating damage due to stroke is in the range of 10 to 300 mg/kg. Similar dosages are useful in treating damage resulting from free radical generation during inflammation, either as a ...

Optimal Survey Design For Community Intervention Evaluations: Cohort Or Cross-Sectional?, Paula Diehr

Paula Diehr

Community intervention evaluations that measure changes over time may conduct repeated cross-sectional surveys, follow a cohort of residents over time, or (often) use both designs. Each survey design has implications for precision and cost. To explore these issues, we assume that two waves of surveys are conducted, and that the goal is to estimate change in behavior for people who reside in the community at both times. Cohort designs are shown to provide more accurate estimates (in the sense of lower mean squared error) than cross-sectional estimates if (1) there is strong correlation over time in an individual's behavior ...

The Effectiveness Of A Preoperative Patient Education Handbook In Decreasing Anxiety Of Veterans Undergoing Elective Surgery, Garletta White Steen

Theses & Dissertations

The purpose of this experimental, pretest/posttest study was to examine the effectiveness of a preoperative patient education handbook developed by postanesthesia care unit (PACU) nurses in decreasing state anxiety of veterans undergoing minor elective surgery. State anxiety was measured by the State Anxiety Scale of the State-Trait Anxiety Inventory, developed by Spielberger, Gorsuch, Luschene, Vagg, and Jacobs (1983). The population for the study was composed of veterans undergoing elective surgery in a hospital which is part of the South Texas Veterans Healthcare System. The sample consisted of 38 patients admitted to the hospital for a variety of minor elective ...

Invasion Of Caco-2 Cells By Salmonella Typhimurium (Copenhagen) Isolates From Healthy And Sick Chickens, Theodore J. Kottom, Lisa K. Nolan, John Brown

Lisa K. Nolan

In a previous study, Salmonella isolates of sick birds were distinguished from those of apparently healthy birds by their high degree of invasion of tissue culture cells. In this study, a single pair of Salmonella isolates was examined to determine the source of this observed difference in invasion. When isolates were allowed to invade Caco-2 cells for 8 hours, the isolate from the sick bird (S) appeared to invade in greater numbers than did the isolate from the healthy bird (H). However, when invasion was distinguished from intracellular growth/survival, it was found that H invaded in greater numbers than ...

Influence Of Chondroitinase On Indirect Hemagglutination Titers And Phagocytosis Of Pasteurella Multocida Serogroups A, D And F, Richard B. Rimler, Karen B. Register, Tibor Magyar, Mark R. Ackermann

Mark R. Ackermann

Capsules of Pasteurella multocida serogroups A, D and F contain mucopolysaccharides which block antigenic determinants and prevent phagocytosis. In this study, capsules of serogroup A, D and F strains of P. multocida were depolymerized by enzyme treatment. Capsule depolymerization of serogroup D and F strains with chondroitinase increased indirect hemagglutination (IHA) test titers and enhanced phagocytosis by swine neutrophils. Capsule depolymerization of serogroup A strains with hyaluronidase increased IHA titers, but depolymerization with chondroitinase did not. When serogroup A strains were treated with a combination of chondroitinase and hyaluronidase, IHA test titers were lower than titers of the same strains ...

Ua66/14/4 Kentucky Partnership Newsletter, Vol. Ii, No. 9, Kentucky Partnership For Farm Family Health & Safety

University Organizations

Newsletter created by and about the Kentucky Partnership for Farm Family Health & Safety.

The Spleen Focus-Forming Virus Envelope Glycoprotein, Gp55, And The Block In The Erythropoietin-Induced Differentiation Of Friend Murine Erythroleukemia Cells, Thomas Samuel Lin

Yale Medicine Thesis Digital Library

Unlike normal committed erythroid progenitor cells, which require erythropoietin (EPO) for both proliferation and terminal differentiation, Friend murine erythroleukemia (MEL) cells are EPO-independent and do not differentiate in response to the cytokine. Dimethylsulfoxide (DMSO) induces differentiation and restores responsiveness to EPO. DMSO-treated Friend cells responded to EPO with both increased proliferation and further hemoglobin synthesis. The effects of DMSO upon the expression of EPO receptor (EPOR) mRNA and cell surface receptor were examined. Clone DMSO/R1, an MEL subline resistant to the differentiation-inducing and EPO-sensitizing effects of DMSO, expressed a higher level of EPOR mRNA than parental Friend cells, and ...

Update - December 1995, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Making Human Life Captive to Biomedical Technology: Christianity and the Demise of Human Values

Teacher Certification Among Athletic Training Students, Neil Curtis

Sports Medicine Faculty Publications

No abstract provided.

Volume 38, Issue 6, Canadian Medical Association

Canadian Journal of Surgery

The mission of CJS is to contribute to the effective continuing medical education of Canadian surgical specialists, using innovative techniques when feasible, and to provide surgeons with an effective vehicle for the dissemination of observations in the areas of clinical and basic science research.

Visit the journal website at http://canjsurg.ca/ for more.

Expression And Characterization Of Two Alternatively Spliced Isoforms Of Rat Type I Receptor For Inositol 1,4,5-Trisphosphate, Doris Da May Lin

Yale Medicine Thesis Digital Library

The transmembrane receptor for IP3 is a tetrameric calcium channel located in the endoplasmic reticulum. In many cell types the receptor mediates such complex signals as calcium waves and oscillations. There are multiple receptor isoforms, derived by alternative splicing as well as different genes. The functional significance of these many receptor isoforms has not been determined. To this end, I have generated cell lines that express homotetrameric receptors.Stable lines of the human embryonic kidney (HEK293) cells were established by transfection with cDNAs encoding for two splice variants of the rat type I receptor. The two variants differ in the ...

Nonrandom Gene Organization: Structural Arrangements Of Specific Pre-Mrna Transcription And Splicing With Sc-35 Domains, Yigong P. Xing, Carol V. Johnson, Phillip T. Moen, John A. Mcneil, Jeanne B. Lawrence

Morningside Graduate School of Biomedical Sciences Student Publications

This work demonstrates a highly nonrandom distribution of specific genes relative to nuclear domains enriched in splicing factors and poly(A)+ RNA, and provides evidence for the direct involvement of these in pre-mRNA metabolism. As investigated in hundreds of diploid fibroblasts, human collagen I alpha 1 and beta-actin DNA/RNA showed a very high degree of spatial association with SC-35 domains, whereas three nontranscribed genes, myosin heavy chain, neurotensin, and albumin, showed no such preferential association. Collagen I alpha 1 RNA accumulates within the more central region of the domain, whereas beta-actin RNA localizes at the periphery. A novel approach ...

Multicultural Clients: A Professional Handbook For Health Care Providers And Social Workers. Sybil M. Lassiter.

The Journal of Sociology & Social Welfare

Sybil M. Lassiter, Multicultural Clients: A Professional Handbook for Health Care Providers and Social Workers. Westport, CT: Greenwood Press, 1995. $65.00 hardcover.

Jefferson Alumni Bulletin – Volume Xlv, Number 1, December 1995

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 1, December 1995

We will fight cancer with molecular therapeutics and prediagnostics, page 4

Behavior and economics will challenge prevention, page 6

From genetic understanding to cure, page 9

Computer-based teaching reshapes how students learn, page 12

Will tomorrow’s journals be electronic? Page 14

Jefferson health system upgrades its information technology, page 17

Molecule essential for cell growth and division is discovered at Jeff, page 19

Gas1-Induced Growth Suppression Requires A Transactivation-Independent P53 Function., Giannino Del Sal, Elisabetta M. Ruaro, Rene Utrera, Charles N. Cole

Dartmouth Scholarship

In normal cells, induction of quiescence is accompanied by the increased expression of growth arrest-specific genes (gas). One of them, gas1, is regulated at the transcriptional level and codes for a membrane-associated protein (Gas1) which is down regulated during the G0-to-S phase transition in serum-stimulated cells. Gas1 is not expressed in growing or transformed cells, and when overexpressed in normal fibroblasts, it blocks the G0-to-S phase transition. Moreover, Gas1 blocks cell proliferation in several transformed cells with the exception of simian virus 40- or adenovirus-transformed cell lines. In this paper, we demonstrate that overexpression of Gas1 blocks cell proliferation in ...

Effects Of Rote Exercise, Imagery, And A Material-Based Occupation On Postural Control In Children Ages 3-9, Robin Lengel

Masters Theses

Occupational therapy is based on the concept of enhancing motor, cognitive, sensory, and psycho-social performance through the utilization of purposeful activities. Purposeful activities are doing processes directed toward a planned or hypothesized end result, and can be naturalistic, simulated, or imagery-based (Nelson & Peterson, · 1989). This study compared the effects of a material-based occupation, imagery-based occupation, and rote exercise on the quality and duration of maintaining prone extension in children aged three to nine.· The quality of maintaining the posture was analyzed using the prone extension postural test (Gregory-Flock & Yerxa, 1984). Duration of prone extension for each child was measured in ...

Allergic Bronchopulmonary Aspergillosis: An Unusual Complication Of Bronchial Asthma, S F. Hussain, J A. Khan, M A. Khan

Section of Pulmonary & Critical Care

Asthma is a common medical problem in Pakistan. Allergic Bronchopulmonary Aspergillosis (ABPA), an immune mediated disease, is an unusual complication of bronchial asthma which can result in bronchiectasis, pulmonary fibrosis, respiratory failure and death. Early diagnosis is important so that with proper therapy permanent lung damage can be prevented. First described in 19521 , ABPA was thought to be a rare disorder, but with increased awareness amongst the physicians and better diagnostic techniques, äases are being recognized more frequently. The clinical features of ABPA (cough, fever, hemoptysis and lung infiltrates) are usually mistaken for pulmonary tuberculosis (TB). We present three cases ...

Ponticulin Plays A Role In The Positional Stabilization Of Pseudopods, D. C. Shutt, D. Wessels, K. Wagenknecht, A. Chandrasekhar, Anne L. Hitt, Elizabeth J. Luna, D. R. Soll

Women’s Health Research Faculty Publications

Ponticulin is a 17-kD glycoprotein that represents a major high affinity link between the plasma membrane and the cortical actin network of Dictyostelium. To assess the role of ponticulin in pseudopod extension and retraction, the motile behavior of two independently generated mutants lacking ponticulin was analyzed using computer-assisted two- and three-dimensional motion analysis systems. More than half of the lateral pseudopods formed off the substratum by ponticulin-minus cells slipped relative to the substratum during extension and retraction. In contrast, all pseudopods formed off the substratum by wild-type cells were positionally fixed in relation to the substratum. Ponticulin-minus cells also formed ...

Cruel And Unusual Treatment, Carl Elliott, Charles Weijer

Charles Weijer

No abstract provided.

Effects Of An Aids Education Program On Nurses' Knowledge, Attitudes, And Intention To Behave Toward Patients With Hiv/Aids, Cezar Derla Dumago Jr.

FIU Electronic Theses and Dissertations

This pretest/posttest control group study design sought to determine the effects of an AIDS education program on nurses' knowledge, attitudes and intention to behave toward HIV-positive/AIDS patients. The study, based on Ajzen and Fishbein's Theory of Reasoned Action (TRA), was conducted on a sample of 90 nurses (exp=45 Ss; con=45 Ss), randomly selected from among those employed in one large medical center in South Florida. Only the experimental group participated in a 2-hour AIDS education program. Data were analyzed using descriptive and inferential statistics, which included t-tests for non-independent samples and Pearson's correlation coefficients ...