Medicine and Health Sciences Commons^™

Perivascular Waste Metabolites Clearance In Central Nervous System (Cns), Yiming Cheng

Dissertations

Efficient clearance of interstitial waste metabolites is essential for normal brain homeostasis. Such effective clearance is hampered by the lack of a lymphatic system in the brain, and the cerebrospinal fluid (CSF) is unable to clear large size waste metabolites in the brain. Here, a novel idea that brain arterial endothelium and smooth muscle cells reactivity regulates the clearance of these water-insoluble large size waste metabolites through the perivascular dynamic exchange, and that low dose ethanol promotes this perivascular clearance is proposed.

In Aim 1, the biodistribution of a large size waste metabolite (Amyloid-β protein mimic) in rat perivascular space …

Mitochondria Imaging And Targeted Cancer Treatment, Tinghan Zhao

Dissertations

Mitochondria are essential organelles as the site of respiration in eukaryotic cells and are involved in many crucial functions in cell life. Dysfunction of mitochondrial metabolism and irregular morphology have been frequently found in human cancers. The capability of imaging mitochondria as well as regulating their microenvironment is important both scientifically and clinically. Mitochondria penetrating peptides (MPPs), certain peptides that are composed of cationic and hydrophobic amino acids, are good candidates for mitochondria targeting. Herein, a novel MPP, D-argine-phenylalanine-D-argine-phenylalanine-D-argine-phenylalanine-NH₂ (rFrFrF), is conjugated with a rhodamine-based fluorescent chromophore (TAMRA). The TAMRA-rFrFrF probe exhibits advantageous properties for long-term mitochondria tracking of …

Information Theoretic Measures For Quantifying Sequence-Ensemble Relationships Of Intrinsically Disordered Proteins, Megan C Cohan, Kiersten M Ruff, Rohit V Pappu

2010-2019 OA Pubs

Intrinsically disordered proteins (IDPs) contribute to a multitude of functions. De novo design of IDPs should open the door to modulating functions and phenotypes controlled by these systems. Recent design efforts have focused on compositional biases and specific sequence patterns as the design features. Analysis of the impact of these designs on sequence-function relationships indicates that individual sequence/compositional parameters are insufficient for describing sequence-function relationships in IDPs. To remedy this problem, we have developed information theoretic measures for sequence-ensemble relationships (SERs) of IDPs. These measures rely on prior availability of statistically robust conformational ensembles derived from all atom simulations. We …

Research News. Publications, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period October 1 through December 31, 2019

Effectiveness Of Balloon Angioplasty And Stent Angioplasty: Wound Healing In Critically Limb Ischemic, Wisnu Pamungkas, Patrianef Darwis

The New Ropanasuri Journal of Surgery

Introduction. Critical limb ischemia (CLI) is a vascular disease that has a significant amputation and mortality risk with diabetes mellitus; the most significant risk factor in CLI is prevalent among Indonesian. Endovascular intervention (EVI) is preferred in treating CLI because it is non-invasive and effective. Balloon angioplasty and stent angioplasty are the most common method of EVI in Indonesia. This study aims to compare the effectiveness of balloon angioplasty and stent angioplasty on wound healing in CLI.

Method. A cross sectional study enrolled 90 subjects of CLI who underwent endovascular intervention using balloon angioplasty dan stent angioplasty from …

Association Between The Adequacy Of Preoperative Antituberculosis Treatment With Abdominal Postoperative Morbidity And Mortality On Tuberculosis Patients, Riza El Anshori, Agi S. Putranto

The New Ropanasuri Journal of Surgery

Introduction. The adequacy of tuberculosis treatment before abdominal surgery is a dilemma faced by surgeons who aims for low risk of morbidity and mortality. In addition, there is no data on morbidity and mortality post abdominal operation on TB patients in RSCM and RS Persahabatan. Therefore, this research aims to show the correlation between the adequacy of preoperative TB treatment and postoperative morbidity (fistula enterocutaneous, obstruction, and surgical site infection) and mortality.

Method. This study is a descriptive-analytic cross-sectional study done in Cipto Mangunkusumo Hospital dan Persahabatan Hospital using total sampling method, a total of 59 subjects with …

The Role Of Melatonin In Improving Hypoxia In Malignant Tumor: A Mini-Review, Diani Kartini, Akmal Taher, Sonar S. Panigoro, Rianto Setiabudy, Sri W. Jusman, Sofia M. Haryana, Murdani Abdullah, Primariadewi Rustamadji

The New Ropanasuri Journal of Surgery

No abstract provided.

Pengaruh Pemberian Jus Mentimun Dan Minuman Isotonik Terhadap Tingkat Dehidrasi Pada Latihan Zumba Fitness, Rizki Yudha Pratama, Imas Damayanti, Yati Ruhayati

Jurnal Keolahragaan

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus mentimun dan minuman isotonik terhadap tingkat dehidrasi. Metode yang digunakan yaitu dengan eksperimen dengan desain penelitian cross over design. 8 orang mahasiswa keperawatan UPI 2018 berpartisipasi sebagai sampel dalam penelitian ini. Dehydrating exercise test yang digunakan dalam penelitian ini adalah Zumba fitness selama 60 menit. Instrumen pengambilan data menggunakan Urine Refractometer Spesific Gravity dan 5 visual analog scale. Hasil dari penelitian ini menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara hasil pre-test dan post-test pada jus mentimun dan minuman isotonik terhadap tingkat dehidrasi sebesar p(0.83) dan p(1.52). Pada penilaian subjektif tidak terdapat …

Hubungan Komposisi Tubuh Dengan Kesegaran Jasmani Pada Atlet Hockey, Nandita Nury Latifah, Ani Margawati, Ayu Rahadiyanti

Jurnal Keolahragaan

Komposisi tubuh yang tidak optimal dapat menurunkan kesegaran jasmani atlet sehingga dapat terjadi penurunan performa ketika bertanding. Tujuan dari penelitian ini adalah mengetahui hubungan persen lemak tubuh, persen massa otot, dan somatotype dengan kesegaran jasmani pada atlet hockey. Desain penelitian yaitu cross-sectional dengan jumlah subjek 35 atlet di Pelatihan Hockey Universitas Negeri Semarang dan Universitas Negeri Yogyakarta yang dipilih dengan purposive sampling. Data persen lemak tubuh dan persen massa otot diukur menggunakan bioelectrical impedence analysis (BIA). Data somatotype menggunakan metode antropometri Heath-Carter dan data kesegaran jasmani berupa nilai VO2max diambil menggunakan metode Balke. Analisis data menggunakan uji Pearson, …

Efektivitas Small-Sided Games Dan Interval Training Terhadap Peningkatan Daya Tahan Aerobik Pada Pemain Sepakbola U-17, Andi Tri Arianto, Caly Setyawan

Jurnal Keolahragaan

Penelitian ini bertujuan untuk membandingkan pengaruh antara latihan small sided games (SSG) dan interval training (IT) terhadap daya tahan aerobik pemain sepakbola under-17. Sebanyak 24 pemain sepakbola U-17 yang dibagi menjadi 2 grup: grup SSG (n = 12) dan grup IT (n = 12) mengikuti program latihan selama 6 minggu. Instrumen penelitian yang digunakan adalah Yo-Yo Intermitten Recovery Test. ANAVA dua jalur digunakan untuk proses analisis data. Pemain dari kedua grup menunjukkan peningkatan yang sama pada daya tahan aerobik selama periodesasi latihan 6 minggu. Hasil ini menunjukkan bahwa SSG dan IT sama efektif dalam meningkatkan daya tahan aerobik …

Efektivitas Massage Frirage Dan Kombinasi Back Massage-Stretching Untuk Penyembuhan Nyeri Pinggang, Ardi Utomo, B.M. Wara Kushartanti

Jurnal Keolahragaan

Penelitian ini bertujuan untuk mengungkapkan: (1) pengaruh jenis perlakuan massage frirage dan kombinasi back massage-stretching untuk penyembuhan nyeri pinggang, (2) pengaruh kondisi cedera akut dan kronis terhadap penyembuhan nyeri pinggang, dan (3) interaksi jenis perlakuan dengan kondisi cedera terhadap penyembuhan nyeri pinggang yang ditunjukkan peningkatan ROM pinggang pada pasien Physical Therapy Clinic Fakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta (PTC FIK UNY). Penelitian ini adalah eksperimen dengan desain faktorial 2 x 2, dengan menggunakan tes awal dan tes akhir. Subjek penelitian ini adalah 40 orang pasien klinik PTC yang mengalami nyeri pinggang kronis maupun akut akibat aktivitas kerja yang berjenis kelamin …

Association Between Obesity And Hormone Receptor Characteristics Of Primary Breast Cancer At Cipto Mangunkusumo General Hospital, Jakarta, In 2017, Hardian Gunardi, Diani Kartini

The New Ropanasuri Journal of Surgery

Introduction. Obesity is an independent risk factor and prognostic factor of primary breast cancer. Abundant adipose tissue would lead to increment of blood estrogen level; thus, promoting proliferation of cancer cell, especially those with positive estrogen receptor (ER) and progesterone receptor (PR). No study reported the association between obesity and hormone receptor characteristics of primary breast cancer in Indonesia.

Method. We collected cases of primary breast cancer which is diagnosed and undergone immunohistochemistry examination at Cipto Mangunkusumo General Hospital in 2017. The subjects divided into obese group and non-obese group. The ER and PR characteristics of both groups were compared …

Correlation Between Internal Jugular Vein Tunnel Cuffed Catheter Tip Position As Hemodialysis Access With Suspected Catheter Related Bacteremia And Related Risk Factors At Rscm 2018–2019, Susatyo J. Pratomo, Akhmadu Muradi

The New Ropanasuri Journal of Surgery

Introduction. Infection is the main complication of prolonged–term catheter uses as hemodialysis access. The KDOQI recommends the insertion of tunnel venous hemodialysis catheter in the right internal jugular vein (IJV) where the tip placed in the right atrium and the arterial opening enfacing the mediastinum. The previous study showed that the incidence of catheter–related bacteremia (CRB) is 35% at three months' use and 54% at six months' use. The TCC tip position as hemodialysis access in left IJV is correlated more to dysfunction and infection compared to the right IJV.

Method. A cross–sectional study was conducted with 62 subjects …

Initial Experience On Laparoscopic Pyeloplasty In Persahabatan General Hospital, Jakarta: A Case Series, Moammar Ar Siregar, Hendy Mirza

The New Ropanasuri Journal of Surgery

Introduction. Untreated ureteropelvic junction obstruction would lead to infection and many other complications. The gold standard to treat this condition is pyeloplasty. Nowadays, laparoscopic pyeloplasty has emerged as a potential modality better than open pyeloplasty.

Method. Data retrospectively obtained from the medical records of UPJO patients at Persahabatan Hospital, Jakarta. The patient’s age, gender, weight, and BMI noted. Duration of operation, intraoperative blood loss, and complications recorded as the intraoperative status. Length of hospital stay, pain score on the first post-operative day, time to do the daily activity, and return to work recorded as post-operative variables of this …

Connectivity Differences Between Gulf War Illness (Gwi) Phenotypes During A Test Of Attention, Tomas Clarke, Jessie Jamieson, Patrick Malone, Rakib U. Rayhan, Stuart Washington, John W. Vanmeter, James N. Baraniuk

Department of Mathematics: Faculty Publications

One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not relieved by sleep. We have modeled exertional exhaustion by comparing magnetic resonance images from before and after submaximal exercise. One third of the 27 GWI participants had brain stem atrophy and developed postural tachycardia after exercise (START: Stress Test Activated Reversible Tachycardia). The remainder activated basal ganglia and anterior insulae during a cognitive task (STOPP: Stress Test Originated Phantom Perception). Here, the role of attention …

Professional Development For Clerkship Administrators: A 16-Year Overview Of The Clerkship Administrator Certificate Program, Donnita Pelser, Cathy Chavez, Lindsey Allison, Virginia Cleppe, Gary L Beck Dallaghan

Medical Education Faculty Publications

Background: Increasing accreditation requirements as well as transformations in medical school curricula necessitate administrative staff who are not only invested in the clerkship coordinator role but also view what they do as a career. To date, there has been a lack of professional development opportunities for clerkship administrators.

Methods: In 2003, the Central Group on Educational Affairs of the Association of American Medical Colleges recognized a need for professional development for clerkship administrators. The Clerkship Administrator Certificate Program emerged from that decision and presented for the first time in 2004 in Omaha, Nebraska. This article provides an overview of the …

A Case Of Ana-Negative Systemic Sclerosis Treated With Methylprednisolone, Carminda P. Rogacion, Veronica S, Uy, Reynaldo L. Ugalde, Emmerson Gale S. Vista

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Systemic sclerosis is a multi-systemic disease characterized by excessive fibrosis, inflammation, and vasculopathy. Common clinical features include skin thickening, telangiectasias, salt and pepper skin, beak-shaped nose, and microstomy. We report a case of ANA-negative systemic sclerosis in a male patient.

Case illustration: Our patient presented with a 10-month history of diffuse hyperpigmentation, skin tightening and decreased mouth aperture, accompanied by digital ulcers, hypopigmented macules and violaceous discoloration of the digits upon exposure to cold temperature. Punch biopsy done revealed mild acanthosis of the epidermis with basal cell layer hyperpigmentation, vacuolar alteration and thickening of the basement membrane …

Characteristics Of Habitat, Distribution, And Diversity Of Anopheles Spp In Kemelak Bindung Langit Village, Ogan Komering Ulu Regency, South Sumatra, Giri Maretasari, Yuanita Windusari, Syafrina Lamin, Laila Hanum, Dwi Septiawati

Journal of Environmental Science and Sustainable Development

Malaria is an infectious disease caused by Plasmodium andis transmitted through the bite of a female Anopheles vector. Ogan Komering Ulu (OKU) is a district in South Sumatra that is endemic to malaria. The study aims to determine habitat type, environmental factors that influence larvae development, and distribution of Anopheles larvae. The experiment was conducted from January to February 2019 in the Kelurahan Kemelak Bindung Langit, OKU. Species identification was carried out in the Entomology Laboratory, Baturaja Health Research and Development Center, OKU. Sampling locations were determined based on field observations, through simple purposive sampling. Identification of mosquito larvae which …

Histopathological Diagnosis Of Diseases Affecting Amphibians Inhabiting Kihansi Gorge, Tanzania, Joshua J Malago

Tanzania Journal of Science

Kihansi gorge is a natural habitat to Kihansi spray toad (KST), Nectophrynoides asperginis. The toad is extinct in its natural habitat partly due to diseases. Efforts to successfully re-introduce it are primed by awareness and mitigation of prevalent diseases at the gorge. This study aimed at exploring the prevalent amphibian diseases at and around Kihansi gorge. A total of 182 individuals from Petropedetes yakusini (n = 60), Nectophrynoides tornieri (n = 60) and Leptopelis uluguruensis (n = 62) species were collected, humanely sacrificed, fixed in formalin, routinely processed, sectioned, stained with haematoxylin and eosin and analysed for diseases by histopathology. …

Association Between Obesity And History Of Atopy With Atopic Dermatitis In Children: A Cross-Sectional Study, Putu Nila Wardhani Batan, Ariana Ariana, Made Wardhana

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: The prevalence of atopic dermatitis (AD) has rapidly increased in the past 4 decades and has been mostly observed in children. The prevalence of obesity has also significantly increased worldwide, suggesting that the two conditions may be associated.

Methods: This retrospective analytic study involved a cross-sectional design and used secondary data taken from the medical record of patients who visited the Pediatric Dermatology Subdivision at Dermatology and Venereology Polyclinic Sanglah General Hospital from January 2015 to December 2015. Thirty-two samples were selected.

Results: The prevalence ratio of obesity among subjects with AD was 2.178 (95% CI …

Research News. Grants, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October-December 2019

Bedside Thyroid Palpation Technique As Indicator For Penetration/Aspiration Risk In Stroke Patients, Yung-Chun Chi, Mu-Hung Tsai, Jerry Tsung-Kai Lin, Yi-Chen Yu, Shih-Chung Chang

Rehabilitation Practice and Science

Background: Bedside thyroid cartilage palpation technique is a quick and non-invasive swallowing screening test. However, the correlation between thyroid cartilage movement and penetration/aspiration risks in stroke patients has not been conclusive to date. Therefore, we compared the result of videofluoroscopic swallowing study (VFSS) and bedside thyroid cartilage palpation to determine the penetration/ aspiration risks in stroke patients. Material and methods: Our study included 53 patients admitted to a medical center for rehabilitation within 6-months of stroke onset. We recorded penetration-aspiration scale by VFSS and compared it with a bedside thyroid cartilage palpation technique. Results: Our results show significant higher rates …

Effect Of 3d Printed Tablet Shape On Drug Release Profile, Christina Gedeon

Theses

There is a growing interest in utilizing additive manufacturing (AM) as a manufacturing tool to develop oral tablets for personalized medicine. This ultimate goal in mind, this study explores the feasibility of extrusion-based fused deposition modeling (FDM) to 3D print oral tablets with tunable design to control drug release profile. Tablets are printed using poly(vinyl alcohol) (PVA) loaded with model drugs: acetaminophen and caffeine. Hot melt extrusion (HME) is used to fabricate PVA filaments loaded with acetaminophen and caffeine. These filaments are used to fabricate a range of tablets with varying designs to prepare immediate and delayed release tablets. Thermal …

Psychoeducation “Aku Peduli” For Parent With Typically Developing Children At An Inclusive Kindergarten, Andi Nur Zamzam Arman, Farida Kurniawati

ASEAN Journal of Community Engagement

This study examined the effectiveness of “AKU PEDULI” psychoeducation in helping the parents of typically developing children to increase their knowledge of special needs children and inclusive education at an inclusive kindergarten. “AKU PEDULI” is abbreviated from Anak Berkebutuhan Khusus dan Pendidikan Inklusif (Special Needs Children & Inclusive Education). Quantitative methods were used in both the pre-test and post-test parts of the research. Six mothers aged 28–34 years, of typically developing children were selected to participate in the study through accidental sampling. Participants were required to be parents of typically developing children who attend an inclusive kindergarten and who have …

Patient Safety Smartphone Application For Quality Assurance In Primary Healthcare Facilities, Levina Chandra Khoe, Ajeng Pramastuty, Boy Subirosa Sabarguna, Herquranto Herqutanto

ASEAN Journal of Community Engagement

In order to achieve high-quality healthcare, patient safety should be improved and monitored regularly. Moreover, accreditation on healthcare facilities is being requested in recent years. Mobile application can serve as a tool for community healthcare centre’s (Puskesmas) to assess their accreditation score, especially patient safety. To provide as a tool for self-monitoring for patient safety elements. This is a case-based article focuses on the development of smartphone application using the input-process-output-outcome scheme as the framework. We reviewed regulation of health minister on Puskesmas accreditation and developed a checklist and scoring for patient safety components. This is the first mobile application …

Model Hewan Coba Pada Penelitian Diabetes, Fauzul Husna, Franciscus D. Suyatna, Wawaimuli Arozal, Erni H. Purwaningsih

Pharmaceutical Sciences and Research

The animal model has been widely used and contributed vastly to the scientific research over the years. While it can be used as an alternate subject in a study, the selection of the animal is crucial to assess and investigate the influence of the environment and genes on the pathogenesis of a disease. Many factors contribute to the choosing of the animal. They can be ranged from the similarities with the modelled object, easily looked after with less expensive cost, good reproductive performance, ability to produce blood and tissue samples, well-known genetic composition, and the status of the disease can …

Cytotoxic Activity Of Stem Of Pycnarrhena Cauliflora Through Apoptosis Induction On Human Breast Cancer Cell Line T47d, Masriani, Rudiyansyah, Rini Muharini, Eny Enawaty

Pharmaceutical Sciences and Research

Cytotoxic activities of extracts of Pycnarrhena cauliflora leaves, stems and roots on some human cancer cells have been known. However, the cytotoxicity of stem of Pycnarrhena cauliflora on human breast cancer cell line T47D through an apoptosis induction has not been proven yet. This study was an effort in understanding the cytotoxic activity of stem of Pycnarrhena cauliflora through apoptosis induction. The crude ethanol extract was partitioned between n-hexane and dichloromethane at pH 3, 7 and 9, which was subsequently tested for their cytotoxic activity against human breast cancer cell line T47D by using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT). Flow cytometric …

Voice Disorders In Teachers, Hsin-Yu Chien, Feng-Chuan Lin, Yu-Lin Huang

Rehabilitation Practice and Science

Teachers have higher occupational voice demands than the general populations. In addition to speaking intensively in a noisy environment for a long period of time, the lack of vocal hygiene education and vocal training experience will lead to high-risk for developing voice disorders. Although voice disorders are not life-threatening diseases, it affects teachers in many aspects. In addition to impacting teachers' personal physical and psychological condition, it also interferes with the quality of students' learning, which then bring down teachers' teaching and life quality, and even more so on teachers' mental health and career path. In order to help teachers …

A Focal Survey Of Medical Professionals' Conceptions Of Gastrostomy In Patients With Dysphagia After Stroke In Taiwan, Sheng-Hao Cheng, Yi-Ching Chen, Ming-Yen Hsiao, Tyng-Guey Wang

Rehabilitation Practice and Science

Background and aims: People with dysphagia may require long-term tube feeding to maintain adequate nutrition. In Taiwan, nasogastric (NG) tubes are more commonly used than gastrostomy tubes. This practice is inconsistent with international treatment guidelines. Medical professionals' attitudes toward treatment may influence patients' decisions. Therefore, we designed a questionnaire to assess whether medical professionals' conceptions of gastrostomy are consistent with current international treatment principles. Methods: We used an online questionnaire hosted on ＂Google Forms＂ to collect medical professionals' conceptions of gastrostomy. Societies related to dysphagia distributed copies of the questionnaire to their members. The professionals included specialists (physiatrists, otolaryngologists, oral …

Retrospective Study Of Neurogenic Bladder Complications In Patients With Chronic Spinal Cord Injury, Sheng-Min Chang, Sheng-Wei Zeng

Rehabilitation Practice and Science

Recent advances in medicine have greatly prolonged the average lifespan of patients with chronic spinal cord injury (SCI). However, many complications arise as the disease enters the chronic phase. SCI is known to cause limb weakness and paresthesia, it also causes multiple system abnormalities that cannot be easily ignored. Particularly troublesome issues develop due to the urinary system complications resulting from the neurogenic bladder. These include overactive bladder, detrusor external sphincter dyssynergia, vesicoureteral reflux, urolithiasis, urinary tract infection (UTI), and even chronic kidney disease. All these issues cause annoying problems that disturb the patient’s health and quality of life. The …