Medicine and Health Sciences Commons^™

Perivascular Waste Metabolites Clearance In Central Nervous System (Cns), Yiming Cheng

Dissertations

Efficient clearance of interstitial waste metabolites is essential for normal brain homeostasis. Such effective clearance is hampered by the lack of a lymphatic system in the brain, and the cerebrospinal fluid (CSF) is unable to clear large size waste metabolites in the brain. Here, a novel idea that brain arterial endothelium and smooth muscle cells reactivity regulates the clearance of these water-insoluble large size waste metabolites through the perivascular dynamic exchange, and that low dose ethanol promotes this perivascular clearance is proposed.

In Aim 1, the biodistribution of a large size waste metabolite (Amyloid-β protein mimic) in rat perivascular space …

Mitochondria Imaging And Targeted Cancer Treatment, Tinghan Zhao

Dissertations

Mitochondria are essential organelles as the site of respiration in eukaryotic cells and are involved in many crucial functions in cell life. Dysfunction of mitochondrial metabolism and irregular morphology have been frequently found in human cancers. The capability of imaging mitochondria as well as regulating their microenvironment is important both scientifically and clinically. Mitochondria penetrating peptides (MPPs), certain peptides that are composed of cationic and hydrophobic amino acids, are good candidates for mitochondria targeting. Herein, a novel MPP, D-argine-phenylalanine-D-argine-phenylalanine-D-argine-phenylalanine-NH₂ (rFrFrF), is conjugated with a rhodamine-based fluorescent chromophore (TAMRA). The TAMRA-rFrFrF probe exhibits advantageous properties for long-term mitochondria tracking of …

Information Theoretic Measures For Quantifying Sequence-Ensemble Relationships Of Intrinsically Disordered Proteins, Megan C Cohan, Kiersten M Ruff, Rohit V Pappu

2010-2019 OA Pubs

Intrinsically disordered proteins (IDPs) contribute to a multitude of functions. De novo design of IDPs should open the door to modulating functions and phenotypes controlled by these systems. Recent design efforts have focused on compositional biases and specific sequence patterns as the design features. Analysis of the impact of these designs on sequence-function relationships indicates that individual sequence/compositional parameters are insufficient for describing sequence-function relationships in IDPs. To remedy this problem, we have developed information theoretic measures for sequence-ensemble relationships (SERs) of IDPs. These measures rely on prior availability of statistically robust conformational ensembles derived from all atom simulations. We …

Research News. Publications, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period October 1 through December 31, 2019

Effectiveness Of Balloon Angioplasty And Stent Angioplasty: Wound Healing In Critically Limb Ischemic, Wisnu Pamungkas, Patrianef Darwis

The New Ropanasuri Journal of Surgery

Introduction. Critical limb ischemia (CLI) is a vascular disease that has a significant amputation and mortality risk with diabetes mellitus; the most significant risk factor in CLI is prevalent among Indonesian. Endovascular intervention (EVI) is preferred in treating CLI because it is non-invasive and effective. Balloon angioplasty and stent angioplasty are the most common method of EVI in Indonesia. This study aims to compare the effectiveness of balloon angioplasty and stent angioplasty on wound healing in CLI.

Method. A cross sectional study enrolled 90 subjects of CLI who underwent endovascular intervention using balloon angioplasty dan stent angioplasty from …

Association Between The Adequacy Of Preoperative Antituberculosis Treatment With Abdominal Postoperative Morbidity And Mortality On Tuberculosis Patients, Riza El Anshori, Agi S. Putranto

The New Ropanasuri Journal of Surgery

Introduction. The adequacy of tuberculosis treatment before abdominal surgery is a dilemma faced by surgeons who aims for low risk of morbidity and mortality. In addition, there is no data on morbidity and mortality post abdominal operation on TB patients in RSCM and RS Persahabatan. Therefore, this research aims to show the correlation between the adequacy of preoperative TB treatment and postoperative morbidity (fistula enterocutaneous, obstruction, and surgical site infection) and mortality.

Method. This study is a descriptive-analytic cross-sectional study done in Cipto Mangunkusumo Hospital dan Persahabatan Hospital using total sampling method, a total of 59 subjects with …

The Role Of Melatonin In Improving Hypoxia In Malignant Tumor: A Mini-Review, Diani Kartini, Akmal Taher, Sonar S. Panigoro, Rianto Setiabudy, Sri W. Jusman, Sofia M. Haryana, Murdani Abdullah, Primariadewi Rustamadji

The New Ropanasuri Journal of Surgery

No abstract provided.

Pengaruh Pemberian Jus Mentimun Dan Minuman Isotonik Terhadap Tingkat Dehidrasi Pada Latihan Zumba Fitness, Rizki Yudha Pratama, Imas Damayanti, Yati Ruhayati

Jurnal Keolahragaan

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus mentimun dan minuman isotonik terhadap tingkat dehidrasi. Metode yang digunakan yaitu dengan eksperimen dengan desain penelitian cross over design. 8 orang mahasiswa keperawatan UPI 2018 berpartisipasi sebagai sampel dalam penelitian ini. Dehydrating exercise test yang digunakan dalam penelitian ini adalah Zumba fitness selama 60 menit. Instrumen pengambilan data menggunakan Urine Refractometer Spesific Gravity dan 5 visual analog scale. Hasil dari penelitian ini menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara hasil pre-test dan post-test pada jus mentimun dan minuman isotonik terhadap tingkat dehidrasi sebesar p(0.83) dan p(1.52). Pada penilaian subjektif tidak terdapat …

Hubungan Komposisi Tubuh Dengan Kesegaran Jasmani Pada Atlet Hockey, Nandita Nury Latifah, Ani Margawati, Ayu Rahadiyanti

Jurnal Keolahragaan

Komposisi tubuh yang tidak optimal dapat menurunkan kesegaran jasmani atlet sehingga dapat terjadi penurunan performa ketika bertanding. Tujuan dari penelitian ini adalah mengetahui hubungan persen lemak tubuh, persen massa otot, dan somatotype dengan kesegaran jasmani pada atlet hockey. Desain penelitian yaitu cross-sectional dengan jumlah subjek 35 atlet di Pelatihan Hockey Universitas Negeri Semarang dan Universitas Negeri Yogyakarta yang dipilih dengan purposive sampling. Data persen lemak tubuh dan persen massa otot diukur menggunakan bioelectrical impedence analysis (BIA). Data somatotype menggunakan metode antropometri Heath-Carter dan data kesegaran jasmani berupa nilai VO2max diambil menggunakan metode Balke. Analisis data menggunakan uji Pearson, …

Efektivitas Small-Sided Games Dan Interval Training Terhadap Peningkatan Daya Tahan Aerobik Pada Pemain Sepakbola U-17, Andi Tri Arianto, Caly Setyawan

Jurnal Keolahragaan

Penelitian ini bertujuan untuk membandingkan pengaruh antara latihan small sided games (SSG) dan interval training (IT) terhadap daya tahan aerobik pemain sepakbola under-17. Sebanyak 24 pemain sepakbola U-17 yang dibagi menjadi 2 grup: grup SSG (n = 12) dan grup IT (n = 12) mengikuti program latihan selama 6 minggu. Instrumen penelitian yang digunakan adalah Yo-Yo Intermitten Recovery Test. ANAVA dua jalur digunakan untuk proses analisis data. Pemain dari kedua grup menunjukkan peningkatan yang sama pada daya tahan aerobik selama periodesasi latihan 6 minggu. Hasil ini menunjukkan bahwa SSG dan IT sama efektif dalam meningkatkan daya tahan aerobik …

Efektivitas Massage Frirage Dan Kombinasi Back Massage-Stretching Untuk Penyembuhan Nyeri Pinggang, Ardi Utomo, B.M. Wara Kushartanti

Jurnal Keolahragaan

Penelitian ini bertujuan untuk mengungkapkan: (1) pengaruh jenis perlakuan massage frirage dan kombinasi back massage-stretching untuk penyembuhan nyeri pinggang, (2) pengaruh kondisi cedera akut dan kronis terhadap penyembuhan nyeri pinggang, dan (3) interaksi jenis perlakuan dengan kondisi cedera terhadap penyembuhan nyeri pinggang yang ditunjukkan peningkatan ROM pinggang pada pasien Physical Therapy Clinic Fakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta (PTC FIK UNY). Penelitian ini adalah eksperimen dengan desain faktorial 2 x 2, dengan menggunakan tes awal dan tes akhir. Subjek penelitian ini adalah 40 orang pasien klinik PTC yang mengalami nyeri pinggang kronis maupun akut akibat aktivitas kerja yang berjenis kelamin …

Association Between Obesity And Hormone Receptor Characteristics Of Primary Breast Cancer At Cipto Mangunkusumo General Hospital, Jakarta, In 2017, Hardian Gunardi, Diani Kartini

The New Ropanasuri Journal of Surgery

Introduction. Obesity is an independent risk factor and prognostic factor of primary breast cancer. Abundant adipose tissue would lead to increment of blood estrogen level; thus, promoting proliferation of cancer cell, especially those with positive estrogen receptor (ER) and progesterone receptor (PR). No study reported the association between obesity and hormone receptor characteristics of primary breast cancer in Indonesia.

Method. We collected cases of primary breast cancer which is diagnosed and undergone immunohistochemistry examination at Cipto Mangunkusumo General Hospital in 2017. The subjects divided into obese group and non-obese group. The ER and PR characteristics of both groups were compared …

Correlation Between Internal Jugular Vein Tunnel Cuffed Catheter Tip Position As Hemodialysis Access With Suspected Catheter Related Bacteremia And Related Risk Factors At Rscm 2018–2019, Susatyo J. Pratomo, Akhmadu Muradi

The New Ropanasuri Journal of Surgery

Introduction. Infection is the main complication of prolonged–term catheter uses as hemodialysis access. The KDOQI recommends the insertion of tunnel venous hemodialysis catheter in the right internal jugular vein (IJV) where the tip placed in the right atrium and the arterial opening enfacing the mediastinum. The previous study showed that the incidence of catheter–related bacteremia (CRB) is 35% at three months' use and 54% at six months' use. The TCC tip position as hemodialysis access in left IJV is correlated more to dysfunction and infection compared to the right IJV.

Method. A cross–sectional study was conducted with 62 subjects …

Initial Experience On Laparoscopic Pyeloplasty In Persahabatan General Hospital, Jakarta: A Case Series, Moammar Ar Siregar, Hendy Mirza

The New Ropanasuri Journal of Surgery

Introduction. Untreated ureteropelvic junction obstruction would lead to infection and many other complications. The gold standard to treat this condition is pyeloplasty. Nowadays, laparoscopic pyeloplasty has emerged as a potential modality better than open pyeloplasty.

Method. Data retrospectively obtained from the medical records of UPJO patients at Persahabatan Hospital, Jakarta. The patient’s age, gender, weight, and BMI noted. Duration of operation, intraoperative blood loss, and complications recorded as the intraoperative status. Length of hospital stay, pain score on the first post-operative day, time to do the daily activity, and return to work recorded as post-operative variables of this …

Bedside Thyroid Palpation Technique As Indicator For Penetration/Aspiration Risk In Stroke Patients, Yung-Chun Chi, Mu-Hung Tsai, Jerry Tsung-Kai Lin, Yi-Chen Yu, Shih-Chung Chang

Rehabilitation Practice and Science

Background: Bedside thyroid cartilage palpation technique is a quick and non-invasive swallowing screening test. However, the correlation between thyroid cartilage movement and penetration/aspiration risks in stroke patients has not been conclusive to date. Therefore, we compared the result of videofluoroscopic swallowing study (VFSS) and bedside thyroid cartilage palpation to determine the penetration/ aspiration risks in stroke patients. Material and methods: Our study included 53 patients admitted to a medical center for rehabilitation within 6-months of stroke onset. We recorded penetration-aspiration scale by VFSS and compared it with a bedside thyroid cartilage palpation technique. Results: Our results show significant higher rates …

Voice Disorders In Teachers, Hsin-Yu Chien, Feng-Chuan Lin, Yu-Lin Huang

Rehabilitation Practice and Science

Teachers have higher occupational voice demands than the general populations. In addition to speaking intensively in a noisy environment for a long period of time, the lack of vocal hygiene education and vocal training experience will lead to high-risk for developing voice disorders. Although voice disorders are not life-threatening diseases, it affects teachers in many aspects. In addition to impacting teachers' personal physical and psychological condition, it also interferes with the quality of students' learning, which then bring down teachers' teaching and life quality, and even more so on teachers' mental health and career path. In order to help teachers …

A Focal Survey Of Medical Professionals' Conceptions Of Gastrostomy In Patients With Dysphagia After Stroke In Taiwan, Sheng-Hao Cheng, Yi-Ching Chen, Ming-Yen Hsiao, Tyng-Guey Wang

Rehabilitation Practice and Science

Background and aims: People with dysphagia may require long-term tube feeding to maintain adequate nutrition. In Taiwan, nasogastric (NG) tubes are more commonly used than gastrostomy tubes. This practice is inconsistent with international treatment guidelines. Medical professionals' attitudes toward treatment may influence patients' decisions. Therefore, we designed a questionnaire to assess whether medical professionals' conceptions of gastrostomy are consistent with current international treatment principles. Methods: We used an online questionnaire hosted on ＂Google Forms＂ to collect medical professionals' conceptions of gastrostomy. Societies related to dysphagia distributed copies of the questionnaire to their members. The professionals included specialists (physiatrists, otolaryngologists, oral …

Retrospective Study Of Neurogenic Bladder Complications In Patients With Chronic Spinal Cord Injury, Sheng-Min Chang, Sheng-Wei Zeng

Rehabilitation Practice and Science

Recent advances in medicine have greatly prolonged the average lifespan of patients with chronic spinal cord injury (SCI). However, many complications arise as the disease enters the chronic phase. SCI is known to cause limb weakness and paresthesia, it also causes multiple system abnormalities that cannot be easily ignored. Particularly troublesome issues develop due to the urinary system complications resulting from the neurogenic bladder. These include overactive bladder, detrusor external sphincter dyssynergia, vesicoureteral reflux, urolithiasis, urinary tract infection (UTI), and even chronic kidney disease. All these issues cause annoying problems that disturb the patient’s health and quality of life. The …

Effectiveness Of Therapeutic Exercise To Improve Arm And Breast Symptoms In The Post-Operative Breast Cancer Patients, Jui-Hsiang Sung, Chao-Chun Huang, Kai-Jie Yang, Kuan-Cheng Chen

Rehabilitation Practice and Science

Background: Breast cancer is one of the most common cancers in women worldwide. Current options for breast cancer therapy include surgical excision, radiotherapy, and chemotherapy. Many studies have indicated that multifactorial exercise and complete decongestive therapy have positive effects on post-operative/post-radiotherapy lymphedema and shoulder dysfunction (i.e., range of motion). Quality of life after cancer therapy has been a great concern. Many cancer-specific evaluation tools, such as EORTC QLQ - BR23 for breast cancer, have been established in recent years to evaluate quality of life. Objectives: To confirm the effectiveness of therapeutic exercise and complete decongestive therapy on arm and breast …

Is Vertical Orientation Ability And Visual Feedback Training Strategy Useful For Pusher Syndrome After Stroke: A System Reviewarticle, Chien-Hsun Lee

Rehabilitation Practice and Science

Stroke patients with pusher syndrome (PS) have a longer recovery time than those without this disorder. This special syndrome causes difficulty in maintaining balance when sitting or standing, with sufferers ＂pushing and leaning＂ automatically to hemi-side. PS patients may also have cognition impairment, hemi-neglect, or aphasia. Alleviating all these factors requires extensive training for therapists, however, few undergo such training. Wang et. al. published a reviewarticle article in Taiwan Journal of Physical Medicine and Rehabilitation in 2005, and the conclusions drawn were: 1) PS patients have abnormal subjective posture and vertical orientation ability; 2) training strategies that use visual feedback …

Effectiveness Of Post-Acute Rehabilitation On Functional Outcome After Hip Fracture, Yen-Ju Wang, Pei-Hsin Lin, Li-Ning Peng, Mu-Jung Kao, Serena Y.C Lin, Kuan-Hua Huang, Yen-Fang Chen, Miao-Ru Liang

Rehabilitation Practice and Science

Objective: We investigated the effectiveness of functional recovery after 2-week post-acute rehabilitation in elderly people with hip fractures. Design: We divided the patients (N = 129) into 2 groups: the post-acute care (PAC) group (N = 90) that received 2-week in-hospital rehabilitation and the control group (N =39) that were discharged immediately. Outcomes were measured according to the Barthel Index (BI) score. Results: The BI scores at 2 weeks, 3 months, and 6 months were higher in the PAC group than those in the control group, especially for transfer and mobility. Males, aged less than 80 years old, or who …

Bpc 157 Promotes Skeletal Muscle Cells Migration In Association With Up-Regulation Of Paxillin And Vinculin Expression, Szu-Heng Wang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang, Wen-Chung Tsai

Rehabilitation Practice and Science

BPC 157 was first isolated from human gastric juice. It is a stable 15-amino acid fragment (GEPPPGKPADDAGLV), and the healing-promoting effects of BPC 157 have been reported on muscle injury. The aim of this study was to investigate the effect and molecular mechanism of BPC 157 on migration of skeletal muscle cells. Skeletal muscle cells were isolated from the gastrocnemius muscle of Sprague-Dawley rats, and treated with BPC 157. The cell migration was evaluated by transwell filter migration assay. The spreading of cells was evaluated microscopically. The protein expressions of paxillin and vinculin (which were positive regulators of cell migration) …

Assessment Practices Followed By Speech-Language Pathologists For Clients With Suspected Speech Sound Disorder In Taiwan: A Survey Study, Yen-Ning Chang, Li-Li Yeh

Rehabilitation Practice and Science

Speech sound disorder (SSD) is one of the most frequently occurring types of human communication disorders. Approximately one-fourth of the clients of speech-language therapy clinics are diagnosed with SSD by speech-language pathologists (SLPs). Thus, investigating the professional development of SSD assessment by SLPs across various working contexts in Taiwan is important. The present study used a specifically designed questionnaire on SSD assessment. A sample size of 150 SLPs, who comprised 18% of all SLPs in Taiwan (the northern, middle, southern, and eastern regions), were invited to fill in the questionnaire anonymously. The questionnaire contained the following topics: time spent for …

Serial Electromyographic Evaluations In Patients With Unilateral Vocal Fold Paralysis, Yu-Wei Hu, Tuan-Jen Fang, Ying-Hsun Chen, Szu-Heng Wang, Wei-Sen Chen, Shao-Chih Hsu, Yu-Cheng Pei

Rehabilitation Practice and Science

Background: Unilateral vocal fold paralysis causes incomplete closure of the glottis. Clinical manifestations include hoarseness and dysphagia, thus hindering the patients' quality of life. To characterize chronological laryngeal electromyographic changes, this prospective study evaluated laryngeal electromyography and voice at two time points in patients with unilateral vocal fold paralysis. Study design: A retrospective study. Methods: In this study, 12 patients with unilateral vocal fold paralysis who did not receive surgical treatment or injection therapy were recruited. Laryngeal electromyography was performed on the thyroarytenoid-lateral cricoarytenoid (TA-LCA) muscle complex and cricothyroid (CT) muscle, and quantitative analysis was conducted on the TA-LCA muscle …

Risk Factors For Concussion And Head, Neck, And Facial Injuries In Amateur Mixed Martial Arts Athletes, Hsin-Chin Lin, Carl P. C. Chen, Tung-Yang Yu, Yu-Ann Wang, Szu Heng Wang, Yu-Min Chien

Rehabilitation Practice and Science

The popularity of mixed martial arts (MMA) has been on the rise globally since the year 2000 and Taiwan is no exception. Because MMA is a contact sport, it can cause sport-related injuries, especially concussion and head, neck, and facial injuries. This is the first study to analyse the risk of concussion and other head, facial, and neck injuries in amateur MMA competitions in Taiwan. Forty-eight competitors were enrolled in this study. The epidemiology of injuries was recorded and analysed using logistic regressions and odds ratios in STATA 14; data analysed included locations and incidence of concussion and head, neck, …

Factors Influencing The Use Of Inpatient Rehabilitation Services Among Amputees In Acute Hospitals: An Observational Study, Ya-Ling Huang, Ming-Chung Yang, Chun-Chieh Wu, Tung-Chou Li

Rehabilitation Practice and Science

Objective: To examine rates of inpatient rehabilitation (IR) use in a nationwide amputee and determine factors associated with receiving rehabilitation services during acute admission. Methods: This research is a retrospective observational study. We sampled data from a nationally representative sample of 1,000,000 enrollees of the single-payer government-based National Health Insurance (NHI) program in Taiwan from 1996 to 2013. Claims data for rehabilitation during index admission after amputation were analyzed, and factors associated with IR use were identified. Multivariable logistic regression was performed with adjustment for clustering to identify which factors were independently associated with acute IR referral. Results: Among the …

Effect Of In-Vitro Alpha Lipoic Acid Addition On Spermatozoa Motility In Sperm Preparation Process, Gede Wira Buanayuda, Hamdani Lunardhi, Indra Gusti Mansur

Folia Medica Indonesiana

Infertility is a problem for husband and wife, in the last 20 years the number of infertile couples has tended to increase by around 6.5 million pairs. The infertile couple can use the intrauterine insemination method to obtain offspring if a conventional method approach cannot be performed. Insemination requires a sperm preparation stage in which there are centrifugation and resuspension procedures that tend to produce excess reactive oxygen species (ROS). Excessive ROS will damage the motility of the spermatozoa. This study aims to prove the addition of alpha lipoic acid (ALA) as an antioxidant in the process of sperm preparation …

Correlation Of Population And Environmental Behavior With Rat Density Rate In Plague Disease-Focus, Threatened And Safe Areas In Tutur District, Pasuruan Regency, 2016, Evi Noerista Lestari, Susilowati Andajani, Usman Hadi

Folia Medica Indonesiana

Plague disease remains a public health problem in the world. According to the International Health Regulations (IHR), an outbreak is an infectious disease that has the potential to cause an outbreak. The purpose of this study was to analyze a significant relationship between human behavior and the environment with the density of the number of rats in the focus, threatened and outbreak-safe areas in Tutur Regency, Pasuruan Regency, in 2016. This was an observational analytic study with cross correlation sectional where the research variables are population behavior, environment, and the number of rat densities observed once at a time. The …

Analysis Of Ifn-Gamma And Il-10 Levels As Markers Of Inflammation And Response Therapy Of Anti-Tuberculosis In Mdr Lung Tb Patients, Herni Setyawati, Soedarsono Soedarsono, Yulistiani Yulistiani, Umi Fatmawati

Folia Medica Indonesiana

Multidrug-Resistant Tuberculosis (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampisin, the two most potent TB drug. Immune response to against Mycobacterum tuberculosis infection is related to the function of immunity. The function of interferon-γ (pro-inflammatory) is to activate macrophages, to stimulate antimicrobial molecules (to reactive oxygen species and nitric oxide), and to inhibits interleukin-10. Interleukin-10 function is to triggers humoral immunity, to inhibit IFN- γ. This study aimed to analyze level changes and the correlation with clinical data, also months of MDR TB patients who received standard OAT therapy. This was an …

Effect Of Glutamine Supplement Administration On The Reduction Of Muscular Fatigue Post-Eccentric Exercise, Afif Rusdiawan, Taufikkurrachman Taufikkurrachman

Folia Medica Indonesiana

Menopausal period is the period of permanent cessation of menstruation due to reduced or lost ovarian activity. One of the effects of decline estrogen levels during menopause is atropic vulvovaginitis. Consumption of phytoestrogens can reduce menopausal symptoms. Phytoestrogen is found in vegetables and fruits such as tomatoes and red melon. The objective of this study was to compare the effectiveness of red melon juice and tomato on the increase of vaginal wall thickness in menopausal rats. This study revealed an alternative of phytoestrogen sources that is more effective to reduce menopausal symptoms, especially those related to vaginal atrophy to improve …