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Full-Text Articles in Medicine and Health Sciences

Tbi And Tau Loss-Of-Function Both Affect Naïve Ethanol Sensitivity In Drosophila, Gregg Roman Feb 2024

Tbi And Tau Loss-Of-Function Both Affect Naïve Ethanol Sensitivity In Drosophila, Gregg Roman

Faculty and Student Publications

Traumatic brain injury (TBI) is associated with alcohol abuse and higher ethanol sensitivity later in life. Currently, it is poorly understood how ethanol sensitivity changes with time after TBI and whether there are sex-dependent differences in the relationship between TBI and ethanol sensitivity. This study uses the fruit fly Drosophila melanogaster to investigate how TBI affects alcohol sensitivity and whether the effects are sex-specific. Our results indicate that flies have a significantly higher sensitivity to the intoxicating levels of ethanol during the acute phase post-TBI, regardless of sex. The increased ethanol sensitivity decreases as time progresses; however, females take longer …


Inverse Association Between Exercising Blood Pressure Response And Left Ventricular Chamber Size And Mass In Women Who Habitually Resistance Train, Evan L. Matthews Jan 2024

Inverse Association Between Exercising Blood Pressure Response And Left Ventricular Chamber Size And Mass In Women Who Habitually Resistance Train, Evan L. Matthews

Research Data

Excel document of research data.


Iqos Direct Marketing, Katherine C. Henderson, Nikita G. Kute, Lucy Popova, David L. Ashley, Claire A. Spears, Victoria Churchill, Scott Weaver, Terry Pechacek, Jidong Huang Sep 2023

Iqos Direct Marketing, Katherine C. Henderson, Nikita G. Kute, Lucy Popova, David L. Ashley, Claire A. Spears, Victoria Churchill, Scott Weaver, Terry Pechacek, Jidong Huang

Public Health Datasets

IQOS direct marketing items (email and mail) were collected between September 2019 and July 2021 in Atlanta, Georgia and coded for content-related themes.


Effectiveness Of A Postpartum Breastfeeding Protocol For Avoiding Pregnancy Data, Mary Schneider, Richard Fehring, Thomas Paul Bouchard Aug 2023

Effectiveness Of A Postpartum Breastfeeding Protocol For Avoiding Pregnancy Data, Mary Schneider, Richard Fehring, Thomas Paul Bouchard

Randomized Comparison of Two Internet-Supported Methods of Natural Family Planning

The uses of cervical mucus and basal body temperature as indicators of return to fertility postpartum have resulted in high unintended pregnancy rates. In 2013, a study found that when women used urine hormone signs in a postpartum/breastfeeding protocol this resulted in fewer pregnancies. To improve the original protocol's effectiveness, three revisions were made: (1) women were to increase the number of days tested with the Clearblue Fertility Monitor, (2) an optional second luteinizing hormone test could be done in the evening, and (3) instructions were given to manage the beginning of the fertile window for the first six cycles …


"Evidence That The Woman's Ovarian Cycle Is Driven By An Internal Circamonthly Timing System" Data, Mary Schneider Aug 2023

"Evidence That The Woman's Ovarian Cycle Is Driven By An Internal Circamonthly Timing System" Data, Mary Schneider

Randomized Comparison of Two Internet-Supported Methods of Natural Family Planning

No abstract provided.


Integrating Palliative Care In A Family Nurse Practitioner Curricula - Post Survey Data, Betty Lang, Susan Montgomery, Ellen P. Moore, Amanda Townsend Mar 2023

Integrating Palliative Care In A Family Nurse Practitioner Curricula - Post Survey Data, Betty Lang, Susan Montgomery, Ellen P. Moore, Amanda Townsend

MSN Project Data

There is a growing need to integrate Palliative Care in Family Nurse Practitioner (FNP) curricula. Due to increasing costs in an already overstretched healthcare system, a large portion of primary care is delivered by FNPs, often to older or sicker patients. Therefore, it is imperative that FNPs receive formal educational and professional preparation regarding palliative care resources. One of the Core concepts presented by The American Association of Colleges of Nursing's Essentials: Core Concepts for Professional Nursing Education (2021) is palliative care, as are hospice and supportive care. Graduate Competencies and Recommendations for Educating nursing Students (G-CARES) further describe advanced-level …


Medical Marijuana Knowledge And Attitudes: A Survey Of Dental And Dental Hygiene Faculty And Students, Dara Szyliowicz, Andrew Young, Yesha Golwala Jan 2023

Medical Marijuana Knowledge And Attitudes: A Survey Of Dental And Dental Hygiene Faculty And Students, Dara Szyliowicz, Andrew Young, Yesha Golwala

Eberhardt School of Business Faculty Datasets

Background:

Medical Marijuana (MM) use is increasing, requiring healthcare professionals, such as dentists, to possess a working knowledge of MM. Previous studies have indicated that MM education is lacking in current healthcare education.

Methods:

A 50-question survey was created to assess, in detail, dental and dental hygiene faculty and students knowledge, practice, and attitudes toward MM, and to identify possible correlations between responses. The survey was modeled after a previous survey conducted amongst practicing pharmacists. All faculty dentists, faculty dental hygienists, students and residents at the Arthur A. Dugoni School of Dentistry, University of the Pacific, were invited by email …


Dataset For Effects Of Single-Session Practice Structure On Motor Skill Acquisition And Alpha And Beta Eeg Oscillations, Audrey Porter, Ronald V. Croce, Wayne Smith Jan 2023

Dataset For Effects Of Single-Session Practice Structure On Motor Skill Acquisition And Alpha And Beta Eeg Oscillations, Audrey Porter, Ronald V. Croce, Wayne Smith

Faculty Publications

Although it is known that practicing a motor skill updates the associated internal model, it is still unclear as to how cortical oscillations linked with the motor skill change under differing practice schedules. The current study investigated α- and β-power changes associated with motor skill acquisition. Firstly, we investigated the behavioral effects of practice on motor learning and retention during repetitive (RP) and variable (VP) practice schedules on an anticipation timing task. Secondly, we investigated changes in cortical α (10-13 HZ) and β (15-30 Hz) event-related synchronization and dyssynchronization (ERS/ERD) under RP and VP during early (EP) and late …


Law Enforcement Recruit Health Database, Myles C. Murphy, Simone Radavelli-Bagatini, Garth Allen, Nicolas Hart, Andrea Mosler Jan 2023

Law Enforcement Recruit Health Database, Myles C. Murphy, Simone Radavelli-Bagatini, Garth Allen, Nicolas Hart, Andrea Mosler

Research Datasets

Our study established clear demographic, mental health/physical injury, and physical performance data to be collected in a law enforcement recruit training program for injury surveillance and performance monitoring. Furthermore, we identified several items that were classified as relevant, but unlikely to be reported truthfully. These items which can help inform current practice and assist clinicians to determine the trustfulness of information received by patients when working within law enforcement environments.


De-Identified Post-Conference Survey Results, Mirl 2022 Nov 2022

De-Identified Post-Conference Survey Results, Mirl 2022

Medical Institutional Repositories in Libraries (MIRL)

Includes the data file produced during the assessment phase of the MIRL 2022 symposium. Data was collected from a survey set to MIRL 2022 symposium participants.


Mental Health And Online Learning - Systematic Review Dataset, Stephanie L. Moore Phd, George Veletsianos, Michael Barbour Jan 2022

Mental Health And Online Learning - Systematic Review Dataset, Stephanie L. Moore Phd, George Veletsianos, Michael Barbour

University Libraries & Learning Sciences Faculty and Staff Publications

While there has been a lot of debate over the impact of online and remote learning on mental health and well-being, there has been no systematic syntheses or reviews of the research on this particular issue. In this paper, we review the research on the relationship between mental health / well-being and online or remote learning. Our review shows that little scholarship existed prior to 2020 with most studies conducted during the COVID-19 pandemic. We report four findings: (a) pandemic effects are not well-controlled for in most studies; (b) studies present a very mixed picture, with variability around how mental …


Gastric Bezoars And Glp-1ra Medications [Data Set], Ritesh Patel, Reginald Lord, Tamara C. Preda Jan 2022

Gastric Bezoars And Glp-1ra Medications [Data Set], Ritesh Patel, Reginald Lord, Tamara C. Preda

Medical Papers and Journal Articles

This dataset relates to journal article: Gastroparesis with bezoar formation in patients treated with glucagon-like peptide-1 receptor agonists: Potential relevance for gastric, especially bariatric, surgery.


De-Identified Post-Conference Survey Results, Mirl 2021 Nov 2021

De-Identified Post-Conference Survey Results, Mirl 2021

Medical Institutional Repositories in Libraries (MIRL)

Includes the data file produced during the assessment phase of the MIRL 2021 symposium. Data was collected from a survey set to MIRL 2021 symposium participants.


Dataset For Study: Reliability Of The Kiersma-Chen Empathy Scale In Health Sciences Students, David B. Gillette, Todd E. Davenport, J. Mark Vanness, Rupa Balachandran, Edward L. Rogan, Deepti Vyas, Suzanne M. Galal, Tracey Delnero, Paul Subar, Elisa Chavez Sep 2021

Dataset For Study: Reliability Of The Kiersma-Chen Empathy Scale In Health Sciences Students, David B. Gillette, Todd E. Davenport, J. Mark Vanness, Rupa Balachandran, Edward L. Rogan, Deepti Vyas, Suzanne M. Galal, Tracey Delnero, Paul Subar, Elisa Chavez

Physical Therapy Faculty & Staff Datasets

Background: Empathy is the ability to understand and identify with another person’s feelings and is important in student development.

Purpose: The purpose of this study was to assess reliability of the Kiersma-Chen Empathy Scale (KCES)[1] and its subscales in health professions students.

Methods: Students in six programs received two administrations. Surveys were matched and deidentified before analysis. Total and subscale homogeneity was assessed using Cronbach’s alpha. Association between subscale and total scores was assessed using Pearson correlation. Total and subscale reliability was determined using two-way intraclass correlation coefficients. Minimum detectable change (MDC95)[2] was calculated.

Results: Two …


3d Printed Midface Models For Percutaneous Nasal Osteotomy Surgical Education, Raphael G. Banoub, Kurren S. Gill, Alice R. Karp, Jared M. Goldfarb, Emily S. Sagalow, Roxana Moayer, Howard Krein, Md, Joel J. Stanek, Robert S. Pugliese, Ryan N. Heffelfinger Sep 2021

3d Printed Midface Models For Percutaneous Nasal Osteotomy Surgical Education, Raphael G. Banoub, Kurren S. Gill, Alice R. Karp, Jared M. Goldfarb, Emily S. Sagalow, Roxana Moayer, Howard Krein, Md, Joel J. Stanek, Robert S. Pugliese, Ryan N. Heffelfinger

Department of Otolaryngology Data Sets

No abstract provided.


An Exploration In The Tools Of Options Pricing - Data, Ryan Hinson, Chris Schroeder Apr 2021

An Exploration In The Tools Of Options Pricing - Data, Ryan Hinson, Chris Schroeder

2021 Celebration of Student Scholarship - Oral Presentations

Stock options can be a useful tool in any investor’s portfolio. They allow the skilled investor to increase their leverage and possibility for a higher payout with less risk. However, they are only beneficial if the investor knows how to use them, and if they accurately reflect the price of the option. This presentation hopes to offer some insight into the binomial method of options pricing along with new adjustments to the model in hopes of reflecting a more accurate options price. This, along with the Monte Carlo simulation presented, will hopefully offer some insight into the mathematical investor’s toolbox.


Young Healthy Adults With A Family History Of Hypertension Have Increased Microvascular Reactivity But Decreased Macrovascular Function, Evan L. Matthews, Peter A. Hosick Dr., John J. Guers Dec 2020

Young Healthy Adults With A Family History Of Hypertension Have Increased Microvascular Reactivity But Decreased Macrovascular Function, Evan L. Matthews, Peter A. Hosick Dr., John J. Guers

Research Data

OBJECTIVE: To determine if, like hypertensives, normotensive adults with a family history of hypertension (+FHH) display lower microvascular reactivity and conduit artery function than normotensive adults without a family history of hypertension (-FHH). METHODS: A forearm vascular occlusion test was performed on healthy normotensive adults while resting in the supine position. A near infrared spectroscopy sensor placed on the forearm measured skeletal muscle oxygen saturation kinetics to determine microvascular reactivity. Simultaneously, an ultrasound probe placed on the brachial artery above the occlusion cuff was used to assess flow mediated dilation; a test of macrovascular function. RESULTS: Twenty-two participants were included …


Ecu-Ioht, Mohiuddin Ahmed, Surender Byreddy, Anush Nutakki, Leslie F. Sikos, Paul Haskell-Dowland Jul 2020

Ecu-Ioht, Mohiuddin Ahmed, Surender Byreddy, Anush Nutakki, Leslie F. Sikos, Paul Haskell-Dowland

Research Datasets

In recent times, cyberattacks on Internet of Health Things (IoHT) have continuously been growing, and so it is important to develop robust countermeasures. However, there is a lack of publicly available datasets reflecting cyberattacks on IoHT, mainly due to privacy concerns. To strengthen the cyber security of IoHT, we have developed the dataset, named ECU-IoHT, that is built upon an IoHT environment having different attacks performed that exploit various vulnerabilities. This dataset was designed to help the healthcare security community in analyzing attack behaviour and developing robust countermeasures. To the best of our knowledge, no other publicly available datasets have …


Human Anatomy And Physiology I: Course Map With Expected Learning Outcomes, Carlos Liachovitzky May 2019

Human Anatomy And Physiology I: Course Map With Expected Learning Outcomes, Carlos Liachovitzky

Open Educational Resources

This document contains a list with all the Anatomy and Physiology I expected learning outcomes organized by topics, and grouped into ten units: 1. Introduction to A&P: body plan & organization; 2. Introduction to A&P: homeostasis; 3. The chemical level of organization; 4. Levels of organization: the cellular level of organization; 5. Levels of organization: the tissue level of organization; 6. Support and movement: integumentary system; 7. Support and movement: skeletal system & articulations; 8. Support and movement: muscular system; 9. Regulation, integration, and control: nervous system; 10. Regulation, integration, and control: special senses

Each learning outcome is referred to …


Oral Saline Consumption And The Exercise Pressor Reflex, John J. Del Vecchio, Evan L. Matthews Dr., Peter A. Hosick Dr. Jan 2019

Oral Saline Consumption And The Exercise Pressor Reflex, John J. Del Vecchio, Evan L. Matthews Dr., Peter A. Hosick Dr.

Research Data

The Volume Pilot Study data represents information from participants' health history questionnaire and measurements of changes in blood pressure, heart rate, hemoglobin, hematocrit, serum sodium, and plasma volume during blood draws taken every 30 minutes for 3 hours.

The HG and CPT information was taken in the second part of the study. This data includes participant demographics and various cardiovascular measurements taken during baseline (5min), handgrip exercise (2min), post-exercise ischemia (2min), and recovery (2min). It also includes cardiovascular measurements taken during the cold pressor test which includes baseline (2min), cold pressor test (2min), and recovery (2min)


Data From: Tobacco Smoke Exposure Is An Independent Predictor Of Vitamin D Deficiency In Us Children, Benjamin U. Nwosu, Philip Kum-Nji Jul 2018

Data From: Tobacco Smoke Exposure Is An Independent Predictor Of Vitamin D Deficiency In Us Children, Benjamin U. Nwosu, Philip Kum-Nji

Benjamin U. Nwosu

Manuscript abstract:

IMPORTANCE:

The role of tobacco-smoke exposure on serum vitamin D concentration in US pediatric population is not known. We hypothesized that tobacco smoke exposure would increase the prevalence of vitamin D deficiency in US children.

METHODS:

Representative national data were accessed from the National Health and Nutrition Examination Survey (NHANES) 2009-2010 databank on 2,263 subjects of ages 3 to 17 years. Subjects were categorized into two groups based on their age: children, if <10 >years; and youth if 10 to 17 years. Descriptive and multiple logistic regression analyses were conducted to determine the effect of serum cotinine-verified tobacco smoke …


Survey Data: Data Challenges Of Biomedical Researchers In The Age Of Omics, Rolando Garcia-Milian Mar 2018

Survey Data: Data Challenges Of Biomedical Researchers In The Age Of Omics, Rolando Garcia-Milian

Rolando Garcia-Milian

Survey Data


Data From: Children With Type 1 Diabetes Who Experienced A Honeymoon Phase Had Significantly Lower Ldl Cholesterol 5 Years After Diagnosis, Benjamin U. Nwosu, Bo Zhang, Sanaa S. Ayyoub, Stephanie Choi, Tony R. Villalobos-Ortiz, Laura C. Alonso, Bruce A. Barton Feb 2018

Data From: Children With Type 1 Diabetes Who Experienced A Honeymoon Phase Had Significantly Lower Ldl Cholesterol 5 Years After Diagnosis, Benjamin U. Nwosu, Bo Zhang, Sanaa S. Ayyoub, Stephanie Choi, Tony R. Villalobos-Ortiz, Laura C. Alonso, Bruce A. Barton

Benjamin U. Nwosu

Manuscript abstract:

Importance: Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized.

Aim: To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status.

Subjects and Methods: A longitudinal retrospective cohort study of 123 subjects of mean age 11.9 ± 2.9 years, [male 11.7 ± 2.9 years, (n=55); female 12.0 ± …


Associations Between Medical Cannabis And Prescription Opioid Use In Chronic Pain Patients: A Preliminary Cohort Study [Dataset], Jacob M. Vigil, Sarah S. Stith, Ian M. Adams, Anthony P. Reeve Oct 2017

Associations Between Medical Cannabis And Prescription Opioid Use In Chronic Pain Patients: A Preliminary Cohort Study [Dataset], Jacob M. Vigil, Sarah S. Stith, Ian M. Adams, Anthony P. Reeve

Psychology Datasets

No abstract provided.


Data From: Vitamin D Status In Pediatric Irritable Bowel Syndrome, Benjamin U. Nwosu, Louise S. Maranda, Ninfa Candela Feb 2017

Data From: Vitamin D Status In Pediatric Irritable Bowel Syndrome, Benjamin U. Nwosu, Louise S. Maranda, Ninfa Candela

Benjamin U. Nwosu

Manuscript abstract: IMPORTANCE: Irritable bowel syndrome (IBS) is associated with significant morbidity in children and adolescents, and the therapeutic efficacy of available treatment options is limited. The role of vitamin D supplementation in pediatric IBS is unclear as the vitamin D status of pediatric patients with IBS is unknown. Equally, the relationship of vitamin D status with psychosomatic symptoms in children and adolescents is unclear. AIM: To characterize the vitamin D status of pediatric patients with IBS using a case-control study design. HYPOTHESIS: Serum 25-hydroxyvitamin D [25(OH)D] concentration will be similar between patients with IBS and controls. SUBJECTS AND METHODS: …


Data From: A Predictive Model For Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu Feb 2017

Data From: A Predictive Model For Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Benjamin U. Nwosu

Manuscript abstract:

IMPORTANCE: >50% of patients with new-onset type 1 diabetes (T1D) do not enter partial clinical remission (PCR); early identification of these patients may improve initial glycemic control and reduce long-term complications.

AIM: To determine whether routinely obtainable clinical parameters predict non-remission in children and adolescents with new-onset T1D.

SUBJECTS AND METHODS: Data on remission were collected for the first 36 months of disease in 204 subjects of ages 2-14 years with new-onset type 1 diabetes. There were 86 remitters (age 9.1±3.0y; male 57%), and 118 non-remitters (age 7.0±3.1y; male 40.7%). PCR was defined as insulin-dose adjusted hemoglobin A1c …


Changes In Balance And Joint Position Sense During A 12-Day High Altitude Trek: The British Services Dhaulagiri Medical Research Expedition, Sarah B. Clarke Jan 2017

Changes In Balance And Joint Position Sense During A 12-Day High Altitude Trek: The British Services Dhaulagiri Medical Research Expedition, Sarah B. Clarke

Datasets

Postural control and joint position sense are essential for safely undertaking leisure and professional activities, particularly at high altitude. We tested whether exposure to a 12-day trek with a gradual ascent to high altitude impairs postural control and joint position sense. This was a repeated measures observational study of 12 military service personnel (28±4 years). Postural control (sway velocity measured by a portable force platform) during standing balance, a Sharpened Romberg Test and knee joint position sense were measured, in England (113m), and at 3 research camps (3619m, 4600m and 5140m) on a 12-day high altitude trek in the Dhaulagiri …


Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee Oct 2015

Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Benjamin U. Nwosu

This dataset is the primary data source for a manuscript submitted for publication. Manuscript abstract: Context: The cardiovascular effect of adjunctive metformin therapy in overweight/obese youth with type 1 diabetes (T1D) is unknown. Objective: To compare the effect of prolonged, adjunctive metformin vs. placebo therapy on markers of cardiovascular risk in overweight/obese youth with T1D based on differences in total cholesterol (TC)/ high-density lipoprotein (HDL) ratio, triglycerides (TG)/HDL ratio, Atherogenic Index of Plasma (AIP) log [TG/HDL] ratio, adiponectin/leptin ratio, and 25-hydroxyvitamin D [25(OH)D] concentration. Hypothesis: Adjunctive metformin therapy will improve markers of cardiovascular health in overweight/obese youth with T1D. Setting: …


Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee Oct 2015

Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Benjamin U. Nwosu

This dataset is the primary data source for a manuscript submitted for publication. Manuscript abstract: Context: The cardiovascular effect of adjunctive metformin therapy in overweight/obese youth with type 1 diabetes (T1D) is unknown. Objective: To compare the effect of prolonged, adjunctive metformin vs. placebo therapy on markers of cardiovascular risk in overweight/obese youth with T1D based on differences in total cholesterol (TC)/ high-density lipoprotein (HDL) ratio, triglycerides (TG)/HDL ratio, Atherogenic Index of Plasma (AIP) log [TG/HDL] ratio, adiponectin/leptin ratio, and 25-hydroxyvitamin D [25(OH)D] concentration. Hypothesis: Adjunctive metformin therapy will improve markers of cardiovascular health in overweight/obese youth with T1D. Setting: …


Data From: A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee Jul 2015

Data From: A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Benjamin U. Nwosu

Manuscript abstract: CONTEXT: Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear. OBJECTIVE: To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily dose (TDD) of insulin, and other parameters in overweight/obese youth with T1D. HYPOTHESIS: Adjunctive metformin therapy will improve glycemic control in overweight/obese youth with T1D. DESIGN, SETTING, AND PARTICIPANTS: A 9-mo randomized, double-blind, placebo controlled trial of metformin and placebo in 28 subjects …