Medicine and Health Sciences Commons^™

The Association Of Lower Medication Adherence And Increased Medical Spending, Ryan A. Fuchs

Capstone

Medical prescribing is a common occurrence in daily clinical practice. According to the Centers for Disease Control and Prevention, in 2015-2016 45.8% of the U.S. population used prescription drugs in the past 30 days. (CDC, 2019) Although drug therapy can be effective in treating disease, full benefits are often not realized because many patients do not take their medications as prescribed. There is quite a bit of research out there about non-adherence to medication. Some studies focus on the financial impacts of non-adherence, but most of the studies examine the reasons for medication non-adherence. A gap exists in ...

Discovery Of Sigma-2 Ligands And Prioritization Of Marine Cyanobacteria Extracts For Tnbc Drug Discovery, Katelyn Grenell, Andrea L. Rague, Sahar Mofidi, Jane E. Cavanaugh, Kevin J. Tidgewell

Undergraduate Research and Scholarship Symposium

The role of natural products in drug development is well established. In recent years, marine cyanobacteria have been regarded as a major source of biologically active metabolites with chemical and Figure 5 pharmacological diversity. These cyanobacterial natural products serve as a promising source of drug A. leads for the discovery of therapeutic agents used in the treatment of many diseases of interest, such as CNS disorders, pain, and cancer. We have generated a library of 409 fractions from 37 field collected cyanobacterial samples and screened these fractions against a panel of CNS receptors using radiolabeled ligand competitive-binding assays. Upon analysis ...

Effectiveness And Safety Of Oral Anticoagulants In Non-Valvular Atrial Fibrillation Patients With Prior Bleeding Events: A Retrospective Analysis Of Administrative Claims Databases, G. Y. H. Lip, Allison V. Keshishian, Amiee Kang, Xuemei Luo, Nipun Atreja, Yan Zhang, Patricia Schuler, Jenny Jiang, Huseyin Yuce, Steve Deitelzweig

Publications and Research

Introduction

There are a paucity of real-world data examining effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin in nonvalvular atrial fibrillation (NVAF) patients with prior bleeding.

Methods

This retrospective analysis included data from 5 insurance claims databases and included NVAF patients prescribed OACs with prior bleeding. One-to-one propensity score matching was conducted between NOACs and warfarin and between NOACs in each database. Cox proportional hazards models were used to evaluate the risk of stroke/systemic embolism (SE) and MB.

Results

A total of 244,563 patients (mean age 77; 50% female) with prior bleeding included 55 ...

A Small Peptide Increases Drug Delivery In Human Melanoma Cells, Shirley Tong, Shaban Darwish, Hanieh Hossein Nejad Ariani, Kate Alison Lozada, David Salehi, Maris A. Cinelli, Richard B. Silverman, Kamaljit Kaur, Sun Yang

Pharmacy Faculty Articles and Research

Melanoma is the most fatal type of skin cancer and is notoriously resistant to chemotherapies. The response of melanoma to current treatments is difficult to predict. To combat these challenges, in this study, we utilize a small peptide to increase drug delivery to melanoma cells. A peptide library array was designed and screened using a peptide array-whole cell binding assay, which identified KK-11 as a novel human melanoma-targeting peptide. The peptide and its D-amino acid substituted analogue (VPWxEPAYQrFL or D-aa KK-11) were synthesized via a solid-phase strategy. Further studies using FITC-labeled KK-11 demonstrated dose-dependent uptake in human melanoma cells. D-aa ...

Interrogating Race And Place-Based Inequities In Hiv And Covid-19, Rohan Khazanchi

MD Honors Theses

Over the last four years, I have developed a research focus examining the intersections of race, place, and health. My M.D. Honors Thesis reflects a snapshot of these efforts. In this collection of brief research reports, I leverage area-based measures to investigate structural inequities in three contexts: the HIV epidemic in our hyperlocal community, the early stages of the COVID-19 pandemic, and clinical trials for novel COVID-19 therapeutics. I apply novel social epidemiologic tools to measure and explore disparate outcomes. And, in reflecting upon my findings, I discuss concrete implications for clinicians, researchers, and policymakers alike.

Chapter 1: Neighborhood-Level ...

The Use Of Nebulizer Medications As A Possible Treatment For Covid-19, Jacob Kaufman

Honors College Theses

For the past few years, the COVID-19 pandemic has been the focal point in healthcare and research. This disease has permanently changed daily life and left a historic impact on the world. Most people have felt the effects of this pandemic either directly, via infection, or indirectly, via change in workflow, financial impact, etc. The main question for this virus still remains today; how do we treat this illness effectively? While many ideas are being tested and suggested, a definite answer has yet to be procured. Vaccine rates are climbing on a daily basis, serving as the first and most ...

School Of Pharmacy Class Of 2022 Hooding Ceremony, Cedarville University

Doctor of Pharmacy Hooding Ceremony

No abstract provided.

A State-Wide Education Program On Opioid Use Disorder: Influential Community Members' Knowledge, Beliefs, And Opportunities For Coalition Development, Lindsey Hohmann, Haley Phillippe, Karen Marlowe, Ruth Jeminiwa, Natalie Hohmann, Salisa Westrick, Amanda Fowler, Brent Fox

College of Pharmacy Faculty Papers

Background: Deep South states, particularly Alabama, experience disproportionately higher opioid prescribing rates versus national rates. Considering limited opioid use disorder (OUD) providers in this region, collaborative efforts between non-healthcare professionals is critical in mitigating overdose mortality. The Alabama Opioid Training Institute (OTI) was created in 2019 to empower community members to take action in combatting OUD in local regions. The OTI included: 1) eight full-day in-person conferences; and 2) an interactive mobile-enabled website ( https://alabamaoti.org ). This study assessed the impact of the OTI on influential community members' knowledge, abilities, concerns, readiness, and intended actions regarding OUD and opioid overdose ...

Proposing An Educational Framework For Healthcare Professionals On The Topic Of Substandard Or Falsified Medications And Illegal Online Pharmacies, Margo Elaine Whitehead

Undergraduate Honors Thesis Collection

Background: Substandard or falsified medication prevalence in countries like the United States is documented with much more consistency than developing nations. On the contrary, although online pharmacies have been around for several decades, there is very limited data published establishing the prevalence of online pharmacy use by the general population (Fitler). Currently, there is no standardized curriculum regarding substandard or falsified medications and illegal online pharmacies offered to healthcare providers to combat the problems raised by counterfeits. Therefore, it is necessary to assess institutions’ current stance on implementing concepts in the curriculum and to create an educational framework based on ...

The Use Of Spectral Imaging To Reveal Inorganics And Organics Identity In The Biological Samples, Qamar Alshammari

Pharmaceutical Sciences (PhD) Dissertations

The wavelength is used to identify the exact location and quantify the number of molecules in the spectral imaging system. It aids in identifying materials and studying their quantities by examining how they interact with light. A traditional spectrometer provides spectrum information of chemical compounds, while standard imaging provides the intensity at each pixel of the image. Spectral imaging (SI) combines these two aspects by equipping intensity and spectral data for each pixel. In biomedical research, it is important to assess the inorganics/organics molecules to understand drug activity, cellular toxicity, and distribution. Using the microscopy technique, we found for ...

The Impact Of The Covid-19 Pandemic On Antimicrobial Stewardship Practices And Their Effect On Veterinary Medicine, Erin N. Bradstreet

Honors College

Antimicrobials are essential in the treatment of diseases in both humans and animals, but antimicrobial resistance threatens their efficacy. As more microorganisms become resistant to an ever-growing list of antimicrobials, diseases that used to be simple to treat are becoming increasingly difficult to manage. The major factors contributing to antimicrobial resistance are overuse and misuse of antimicrobials. In order to combat the problem of resistance, antimicrobial stewardship programs that aim to improve antimicrobial prescribing and use practices are becoming increasingly widespread. These programs are quite common in human medicine, but the COVID-19 pandemic disrupted many aspects of life, including antimicrobial ...

Assessing Nutritional Health Knowledge In Sharing Clinic Patients With Diabetes, Minden Huntrods

Capstone Experience

Effective diabetes prevention and management relies on nutritional behaviors, thus a basic level of health knowledge is important for patients with diabetes and their caregivers in their quest to acquire acute glycemic control and minimize negative health outcomes (Ley et al., 2014). The purpose of this study was to assess the nutrition-related health knowledge of patients living with diabetes who are seen at the UNMC Sharing Clinic by use of a verbal questionnaire. This nutritional health knowledge assessment was a quantitative, prospective, survey-based study utilizing descriptive statistics. Approximately 86% of patients were proficient in food group and nutritious foods knowledge ...

The Impact Of Remote Optimization Of Guideline-Directed Medical Therapy In Patients With Nyha Stage Ii And Iii Heart Failure, Maurice N. Tran, Christine Doran, Trevor Laursen, Kellie Graybosch, Jacob Abraham

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Dalbavancin Utilization And Associated Clinical Outcomes Within A Large, Integrated Health System, Meagan Greckel, Brent Footer

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Standardized Pharmacist Led Medication Review In Patients With Recent Falls, Christopher Houpt, Natsuki Kubotera

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Protocol Analysis Of An Antimicrobial Renal Dose Protocol At A Large, Tertiary Medical Center, Nicole Hulsebus, Meagan Greckel, Brent Footer

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of Infusion Reactions Associated With Intravenous Immune Globulin (Ivig) In Neonatal And Pediatric Patients, Katie Couch, Samantha Tatz

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of Pharmacist-Led Transitions Of Care (Toc) Discharge Pilot Program For Reducing 30-Day Readmission Rates In Patients With Chronic Obstructive Pulmonary Disease (Copd, Ann Tong, Hyesoo Chae, Addison Pang, Tony Lucchi

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Tenecteplase Implementation For Ischemic Stroke At A Large Tertiary Medical Center, Laura Kays, Bryce Winn, Aimee Doyle

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Prescribing Patterns Of Antipsychotics For Agitation Or Delirium Management In Non-Critically Ill Patients, Emily Chang, Pamela Levine

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

An Evaluation Of Oral Anticoagulation Initiation After Ischemic Stroke In Patients With Atrial Fibrillation/Atrial Flutter At Hospital Discharge, Jessica Zhao, Meri Slavica, Vanessa Jenkins, Natalie Swearingen

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of An Outpatient Pharmacy Collaboration With A Hospital Quality Initiative To Increase Access To Naloxone At Hospital Discharge, Melissa Yokoyama, Theresa Morikawa, Amber Franck, Adam Saulles

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Implementation And Evaluation Of A Post-Discharge Clinical Patient Follow-Up Service In A Health System Outpatient Pharmacy Setting, Erin Wu, Adam Saulles, Amber Franck, Ryan Bradley

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Fixed-Dose Prothrombin Complex Concentrate Versus Weight-Based Dose For Reversal Of Factor Xa Inhibitors, Kevin Chau, Bryce Winn, Peter Martsin

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Antimicrobial Stewardship On Hospital Discharge: Pharmacist Intervention On Antibiotic Prescribing Practices, Jenny Zhu, Chinh Nguyen, Brent Footer

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2022

No abstract provided.

Preoperative Phytonadione Supplementation For Mitral Valve Intervention Hemostasis, Katherine M. Nguyen, Joshua Francis, Celine Munoz, Torin P. Fitton

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of A Beta-Lactam Antibiotic Allergy Assessment Tool For Patients Receiving Surgical Prophylaxis, Katelynn Tran, Alyssa B Christensen, Tobias Pusch, Jennifer Marfori

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of Specialty Pharmacy Productivity Metrics To Create An Updated Standardized Productivity Tool, David Kim, Adam Saulles, Ryan Bradley

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluating The Impact Of A Pharmacist Run Pharmacotherapy Service On Hepatitis C Outcomes In A Large Integrated Health-System, Jessica Hendrix, Charmaine Hunt, Judy Perkins

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

A Review Of The Clinical And Cost Effectiveness Of Intravenous And Intramuscular Pharmacological Treatment On Acute Agitation In Patients Admitted To The Emergency Department, Ryan Ferris, Carol Keller

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2022

No abstract provided.