Medicine and Health Sciences Commons^™

Knowledge And Attitudes Toward Over-The-Counter Medications Among Undergraduate Students At The University Of Mississippi, Anna S. Dawson

Honors Theses

This study examines and compares knowledge and attitudes towards over-the-counter (OTC) medications among undergraduate college students at the University of Mississippi. OTCs are purchased and administered without a prescription, making them an efficient, safe, and affordable method of healthcare. It is important to determine the attitudes college students have towards these drugs and if they are able to safely and correctly use them. Information gathered from this study can be used to guide future education on medication literacy and to gain insight into how college students use OTCs to medicate themselves. A Qualtrics survey was sent out to a random …

Phytochemical And In-Vitro Cytotoxic Analyses Of Flavonoid Species Isolated From Chromolaena Leivensis, Luke A. Bryant

Electronic Theses and Dissertations

As a leading cause of death worldwide, cancer and its treatments remain a primary source of interest among researchers. Modern studies are looking into bioselective cytotoxicity to create new chemotherapies that do not have the same harsh side effects as those we use today. Natural product research has a promising future for the development of such treatments. Specifically, polar flavonoids may be the key to a bioselective treatment. Such flavonoid species are native to plants, often within flower petals or within the body. A natural antioxidant, they are designed not to harm healthy cells. This study focuses on the plant …

In Adults Older Than 18 Years With Obesity Living In Massachusetts, Can Engaging In A Weight Loss Program Help Them Lose Weight After Insurance Stops Covering Their Weight Loss Medications?, Angel Nagawa

Capstones

Executive summary

The Problem

Obesity rates continue to rise sharply across the United States. Weight loss medications have high compliance but face major insurance restrictions. Strict clinical criteria leave many patients without accessible treatment options.

The Proposed Solution

Launch structured, lifestyle-focused clinical weight loss programs. Provide an effective, accessible alternative to restricted pharmaceutical therapies.

Supporting Evidence

Evaluated data from three distinct randomized controlled trials. Findings confirm successful long-term weight management for program participants. Results prove effective control over serious obesity-related comorbidities.

Policy recommendation

Implement structured lifestyle programs as a primary, frontline intervention modality. Improve broad-scale patient health outcomes across clinical …

Characterization Of Regulation Of Ace2 And Morphogenesis (Ram) Pathway Components In Aspergillus Fumigatus, Devi Naga Jyothi Bale

Theses and Dissertations (ETD)

Aspergillus fumigatus CotA is a conserved protein kinase and predicted orthologue of Cbk1, a terminal kinase of the Regulation of Ace2 and Morphogenesis (RAM) network. In our previous study, disruption of CotA resulted in carbon source dependent invasive growth with the mutant exhibiting preferential growth on glucose but severely impaired growth on alternate carbon sources. This pathway in other fungi has been implicated in the regulation of morphogenesis, stress responses, and virulence, but this study is the first one to characterize it in the pathogenic filamentous fungus.  In yeast, the RAM network includes the CotA ortholog, Cbk1, and associated proteins, …

Are Your Hplc Vials Inert? Lessons Learned From Dilute Benzalkonium Chloride (Bak) Solutions, Fang Zhao, Natalie Gantress, Priyanka Bhatt

Pharmacy Faculty/Staff Publications

Objective.

Benzalkonium chloride (BAK) is a widely used pharmaceutical preservative composed of a mixture of homologs, mainly the C12, C14, and C16 homologs. Due to its permanent positive charge and hydrophobic chain, BAK can adsorb onto HPLC vial surfaces, leading to erroneous analytical results. This study evaluated the compatibility of selected QIS vials with dilute BAK solutions and compared their performance with that of other leading premium brands.

Methods.

Nine QIS vial types (from Pursuit Scientific) and two other premium brands were obtained for evaluation. A 25 ppm BAK solution was prepared in a pH 6.5 phosphate buffer. The solution …

The Study Of The Clinical Toxicity Of Carbon Monoxide In The South Region Of Saudi Arabia: A Case Review, Ahmed Ali Al-Siwar, Ibrahim Mufadhi M Alanazi

Saudi Toxicology Journal

Background: Carbon monoxide (CO) poisoning is an important public health concern associated with substantial morbidity and mortality. However, regional data describing the clinical characteristics of CO poisoning and community awareness in Southern Saudi Arabia remain limited.
Methods: This study comprised two independent components: a retrospective review of confirmed CO poisoning cases and a cross-sectional community awareness survey conducted in Southern Saudi Arabia. The clinical component included 30 confirmed cases from Asir, Najran, and Jazan during 2019–2021, while the separate awareness survey included 117 respondents from the general population selected using convenience sampling. Clinical characteristics, exposure patterns, outcomes, and item-level responses …

The Effects Of Transportation Distribution On Dry Ice Insulated Containers' Thermal Performance, Edmund Tang

Journal of Applied Packaging Research

This study builds upon methodologies established in a 2024 investigation of the combined effects of physical distribution stresses and thermal environments on cold chain packaging performance. Prior results showed that moisture-resistant gel packs generally maintained a vaccine storage range of +2°C to +8°C. However, when exposed to extreme combined stresses, thermal performance degradation of up to 13.5% was observed. The present work applies a similar experimental framework to transportation systems that rely on dry ice as the primary cooling medium, addressing the distinct challenges associated with ultra-cold distribution.

Pharmaceutical products requiring dry ice are highly temperature-sensitive and vulnerable to performance …

November 2026, Swosu Rural Health Center

RURAL ROCKS

Welcome to the Hilltop, Raina Wrather!

Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation | HAIs | CDC

CMS Releases Guidance and Technical Specifications on the Medicaid Direct Care Worker Compensation Reporting Requirement

Immunize - October 21, 2026

Epic launches Connectors to link its AI tools with third-party apps,,,

FDA Approves New Nonprescription Eye Drop for Relief of Eye Redness

FDA Issues Final Guidance on Prescription Drug Apps and Software

Phytochemical Screening And Assessment Of Antibacterial And Antioxidant Activities Of The Crude Extracts From The Leaves Of Vernonia Lasiopus Against Diarrhea-Associated Bacteria, Jackson Iradukunda, Théoneste Muhizi

Pharmaceutical Sciences and Research

Vernonia lasiopus O. Hoffm., a member of the family Asteraceae, has been traditionally used in the management of diarrhea and has also been reported to possess antioxidant properties. However, its biological activities and therapeutic potential have not been adequately established through scientific investigation. This study aimed to evaluate the antibacterial activity of crude leaf extracts of V. lasiopus against Escherichia coli and Staphylococcus aureus and to assess their antioxidant activity using the 2,2 diphenyl 1 picrylhydrazyl (DPPH) assay. The powdered leaves were extracted by maceration using methanol, diethyl ether, cyclohexane, and acetone. Phytochemical screening was performed to determine the classes …

Assessment Of Hypoglycemia Management In Acute Care Hospitals, Carley Warren, Christina Wing, Chenette Burks, Brooke Schmidt, Adam Hasse

HCA Healthcare Journal of Medicine

Background

Hypoglycemia is a common and potentially preventable complication among hospitalized patients, particularly those receiving insulin or other glucose-lowering therapies. Delayed recognition and inconsistent management can increase adverse outcomes. Although protocols exist, variability in treatment selection and timing may influence the likelihood of returning to normoglycemia. Understanding these patterns is critical to optimizing patient safety in acute care settings.

Methods

This retrospective review evaluated hypoglycemia management in adult inpatients across acute care hospitals within a large health system. Patients were included if they were aged 18 years or older, were hospitalized within the health system, and experienced a hypoglycemic event, …

Pharmacovigilance As An Act Of Awareness And Mindfulness, Mahima Silas, Hale Z. Toklu

HCA Healthcare Journal of Medicine

The term “pharmacovigilance” defines the activities related to the collection, detection, assessment, monitoring, and prevention of adverse reactions due to pharmaceuticals. While it is often framed as a technical and regulatory discipline, it can also be understood through a more reflective lens as a form of mindfulness practice. At its core, pharmacovigilance requires a way of thinking that closely mirrors mindfulness, including sustained attention, openness to uncertainty, and deep awareness of human experience. Viewing pharmacovigilance in this way reframes it not just as a safety mechanism, but as a thoughtful, patient-centered approach to medicine.

Evaluation Of Shortened Irinotecan Infusion Times And Adverse Effects Incidence For Gastrointestinal Medical Oncology Patients, Rachel N. Ochs, Daniel J. Donovan, Neha A. Betrabet, Wendy M. Covert

Advances in Cancer Education and Quality Improvement

Background: Irinotecan, a topoisomerase I inhibitor, is commonly used to treat gastrointestinal cancers. The infusion time of irinotecan is usually over 90 minutes; however, studies support the safety and feasibility of 30-minute infusions. A shortened infusion duration may improve patient quality of life, optimize infusion chair utilization, and reduce wait times. Faster infusion rates may increase the risk of acute cholinergic side effects, reported in up to 50% of patients (all grades). Current institutional practice in the gastrointestinal medical oncology (GIMO) clinic involves administering irinotecan over 90 minutes and using atropine as needed for reversing cholinergic symptoms. For patients who …

Implementation Of A Modified Trigger Tool For Adverse Drug Reaction Detection In Pediatric With Covid-19 In Indonesia, Nisa Maria, Avini Risda Khaerani, Indri Yuliani Hamdani, Annisa Lazuardi Larasati, Larasati Arrum Kusumawardani

Pharmaceutical Sciences and Research

Pediatric patients are vulnerable to adverse drug reactions (ADRs), necessitating prompt monitoring of treatment-related adverse events (AEs). This study analyzed ADRs in pediatric COVID-19 patients using a modified trigger tool to identify AEs, followed by causality analysis with the Naranjo Algorithm, and evaluated the tool’s performance. A cross-sectional, single-center retrospective study was conducted at a hospital in Indonesia from August 2020 to July 2021, using total sampling of pediatric patients aged one to≥24 hours with COVID-19. AEs were identified using 23 triggers (15 laboratory result, eight drug-administration). A total of 242 positive triggers were detected among 120 patients (mean two …

Innovative Development Of Synthetic Biology Industry From Perspective Of Deep Integration Of Four Chains, Qin Guo, Chao Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Future industries represent the development direction of technological innovation and emerging industries, and are the main path to accelerate the formation of new quality productivity. As an important subsector of the future industry, synthetic biology industry is becoming a new track and new format for new quality productivity, and various regions are making cutting-edge directions such as synthetic biology industry a hot topic for future industrial layout. Based on the analysis of typical cities such as Shenzhen, Beijing, Tianjin, Shanghai, Hangzhou, and Changzhou, the current integration of the Four Chains in the synthetic biology industry is facing a four-dimensional dilemma …

Ai-Driven Drug Innovation Research: Trends, Challenges, And Countermeasures, Tian Miao, Qi Zhou, Lianzheng Zhou, Weijun Xu, Siyuan Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence (AI) is profoundly transforming the innovation paradigm, industrial ecosystem, and business model of drug research and development. In recent years, the global AI-driven pharmaceutical market has grown rapidly. Major economies, multinational pharmaceutical enterprises, and technology giants are accelerating their strategic deployment. AI pharmaceutical industry has entered a critical stage of transitioning from proof-of-concept to commercial-application. China attaches great importance to the integrated development of AI and the biopharmaceutical industry, but it still faces challenges, including data scarcity, talent shortages, algorithmic black-boxes, regulatory lag, and weak foundations. This study proposes measures from the aspects of data supply, talent cultivation, …

Entrepreneurship Education In Doctor Of Pharmacy Programs: A National Survey Of Course Prevalence, Characteristics, And Assessment Methods, Karl Hess, Richard Beuttler, Reza Taheri

Pharmacy Faculty Articles and Research

Entrepreneurship and innovation are increasingly being recognized as important for pharmacy practice transformation, advancement, and the sustainability of the profession. However, the extent and nature of entrepreneurship education in Doctor of Pharmacy (PharmD) programs remain largely unknown. This study characterizes the prevalence, content, entrepreneurial skills and attitudes, pedagogical approaches, and assessment methods in colleges and schools of pharmacy in the United States (US). A cross-sectional descriptive survey was developed, validated, and administered to all 142 accredited colleges and schools of pharmacy in the US from June to August 2025. A total of 107 institutions responded for a 75% overall response …

Evaluating The Link Between Metabolic Syndrome And Cognitive Dysfunction In People Who Use Cannabis: A Critical Review Of Mechanistic Pathways, Evidence Quality, And Future Research Directions, Ghadah Alharbi, Ahmad H. Alhowail, Ashraf Mahmoud Emara

Saudi Toxicology Journal

Background: Cannabis is the most commonly used internationally controlled substance worldwide, with increasing rates of heavy use and cannabis use disorder (CUD) among adolescents and adults. While epidemiological evidence links cannabis exposure to both metabolic dysfunction and cognitive impairment, these outcomes have been examined predominantly in isolation. The mechanistic relationship between metabolic syndrome (MetS) and cannabis-related cognitive deficits remains poorly characterized. Objective: This review critically appraises the evidence linking cannabis use to metabolic dysfunction and cognitive impairment, proposes an integrative ``Cannabis–Metabolic–Cognitive Axis'' model, and identifies gaps limiting causal inference in the existing literature. Key Findings: Human studies frequently report lower …

Oral Insulin Nanoparticles In Animal Models Of Diabetes: A Systematic Review Of Recent Studies, Dhea Rahmania, Shaum Shiyan, Yulianto Kusnadi, Subandrate Subandrate, Juliana Palungan, Ayeshah Augusta Rosdah

Pharmaceutical Sciences and Research

Oral insulin has long been explored as a potential alternative to injectable insulin therapy. However, the development remains challenging due to enzymatic degradation in the gastrointestinal tract and limited intestinal absorption. Nanoparticle-based delivery systems have also been proposed as a strategy to protect insulin and improve uptake after oral administration. Therefore, this systematic review aimed to summarize recent preclinical studies investigating oral insulin nanoparticles in diabetic animal models and examine the reported pharmacological outcomes. Relevant studies were identified through database searches in PubMed, SpringerLink, and ScienceDirect using predefined keywords related to oral insulin, nanoparticles, diabetes, and animal models. Articles published …

Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao

Pharmacy Faculty Articles and Research

Emerging tools for spatial analysis, systems biology, and synthetic biology offer opportunities to observe, dissect, and perturb cancer mechanisms, to design strategies for the prevention of oncogenesis, and to identify therapies that lead to durable tumor control. Here, we summarize perspectives from the virtual Innovation Lab on “Synthetic and Systems Approaches to Interrogate Spatiotemporal Processes in Cancer” (S3) hosted by the National Institutes of Health (NIH), which assembled interdisciplinary experts to discuss cancer spatial organization and dynamic cellular interactions and how they can be addressed by leveraging novel synthetic and systems biology approaches. These discussions focused especially on cancer initiation, …

A Seven-Year Reflection On Confidence Building And The Evolving Needs Of Pharmacy Residency Applicants, Hindu Rao, Neeloufar Fakourfar

Pharmacy Faculty Articles and Research

Purpose

Description

Lc-Hrms Identification And In Silico Anti-Elastase Analysis Of Cynometra Cauliflora Leaf Bioactive Fractions, Winni Nur Auli, Otniel Prima Saputra Purba, Afifah Khoirunisa, Anjar Hermadi Saputro, Syahrizal Nasution

Chimica et Natura Acta

The development of natural cosmetic raw materials as anti-aging agents is one area of research that receives significant attention. Secondary metabolites and extracts from plants have been widely studied and found to possess anti-aging activity. Previous research yielded results showing very strong antioxidant activity of the extract and fractions of namnam leaves. This study aims to analyze the metabolite from the strongest fraction from antioxidant activity and analyze the interaction of flavonoid metabolites with elastase enzymes in silico. Metabolite analysis was performed using LC-HRMS. The molecular docking study was conducted on protein code 5A09 using Autodock Tools 1.4.7. The skin …

Developing A Cell-Based High-Throughput Screening (Hts) Assay For Antibody-Mediated Amyloid-Beta Clearance, Tran Vo '27, Lucille Whyman, June Javens-Wolfe

Annual Student Research Poster Session

Antibody therapeutics targeting amyloid-beta (Aβ), such as Aducanumab and Lecanemab, are among the first Alzheimer's disease treatments to show clinical potential, with efficacy thought to depend partly on Fc receptor-mediated immune clearance of Aβ plaques. Testing new antibody variants in mouse models is slow and expensive, so TREAT-AD's ADHTS core develops cell-based assays to screen candidates earlier. This project lays the groundwork for a scalable, cell-based high-throughput screening assay of antibody-mediated Aβ clearance. We purified Fc-competent and Fc-silenced Aducanumab, confirmed its specificity for full-length Aβ, and established a live-imaging assay of Aβ uptake in microglia. Assay optimization is ongoing.

Pacific Rxtracts - October 2026, Pacific Rxtracts

Pacific RxTracts

• Tackling Tremors with Tavapadon (featured as the Breaking News article)
• Dupilumab Efficacy and Safety in Patients With Allergic Bronchopulmonary Aspergillosis
• Gefurulimab in Generalized Myasthenia Gravis: Results From the PREVAIL Trial
• Inebilizumab Proves Efficacy in Managing Exacerbations and Rescue Therapy in Phase 3 Myasthenia Gravis Trial
• Coincidence or Carelessness: An Investigation into Potentially Inappropriate Prescribing Cascades
• Nipocalimab Shows Promise for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
• Comparing Intravenous Iron Therapies in the Pediatric Population
• Oseltamivir and Outcomes in Children Hospitalized With Influenza
• Valiltramiprosate’s Impact on Early Alzheimer’s Biomarkers and Outcomes
• Blinatumomab as a Chemotherapy Alternative in Pediatric Acute …

October 2026, Swosu Rural Health Center

RURAL ROCKS

SWOSU Rural Health Center Highlights Innovation at Oklahoma Rural Health Conference

Rural Health. Community Strength

Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation | HAIs | CDC

Epic shifts focus to cybersecurity while AI, interoperability agenda still on track, company says

UnitedHealthcare, Cigna, Centene sign on to CertifyOS' new provider credentialing model

Hospitals' use of AI coding tools cost BCBSA plans $942M more for similar care: analysis

Why Prime Therapeutics is betting on bridging the gaps between medical, pharmacy benefits

HRSA names 10 drugmakers for revised 340B rebate pilot ahead of 2027 launch

HRSA …

Pharmacy Access Is Out Of Reach For One In Six South Carolinians, Bryan L. Love Pharm.D., Tessa J. Hastings Phd, Abby Davies

CORE Research Briefs

A cross-sectional geospatial analysis mapped active South Carolina community pharmacies and used 2020 Census tract data to estimate the population residing within and beyond five-mile pharmacy service areas. About one in six South Carolinians lives more than five miles from an active community pharmacy, with limited access disproportionately affecting rural communities.

Sharksrx Newsletter Fall 2026, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Network Pharmacology Of A Decaffeinated Green Coffee–Turmeric Combination: Potential Therapeutic Activity Against Hypertension And Diabetes Mellitus, Feri Eko Hermanto, Mohammad Saifur Rohman, Victor Alvianoes Guterez Hose, Mifetika Lukitasari, Dwi Adi Nugroho, Nashi Widodo, Inggita Kusumastuty

Makara Journal of Science

Decaffeinated green coffee and turmeric are recognized for their protective effects against hypertension (HTN) and diabetes mellitus (DM). Combining them into a functional drink, green coffee and turmeric (GCT), offers potential health benefits for managing these conditions. This study explored the bioactivity of GCT in HTN and DM through network biology, identifying intersecting protein targets and their roles in inflammation and glucose metabolism. Key proteins identified were AKT1, CCL2, CXCL8, IL-1β, and IL18. Molecular docking revealed that GCT compounds, particularly Cafestol, Chlorogenic Acid, Kahweol, Curcumin, and Desmethoxycurcumin, interacted strongly with AKT1 at its allosteric site, potentially inhibiting its activity. However, …

From Advisory To Action: The Case For Preserving Paccarb In The Fight Against Antimicrobial Resistance, Leila S. Hojat, Muhammad Dhanani, Amy Y. Kang, Salome O. Chitavi, Robert A. Weinstein, Edward Stenehjem

Pharmacy Faculty Articles and Research

The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) was established to advise the government on strategies to mitigate antimicrobial resistance (AMR) and its increasing threat to public health and national security. Its members included experts from diverse disciplines such as healthcare, veterinary medicine, industry, public health, and agriculture who were positioned to interface with key stakeholders and the public in an aspirational multidisciplinary approach to combating AMR. The council was successful in elevating AMR as a national priority and played a crucial role in watershed events for antimicrobial stewardship (AS) such as the development of the second National Action …

Copper Nanoparticles And Their Future In Drug Delivery And Anticancer Therapy, Keykavous Parang, Rajesh Vadlapatla, Cassia Charles, Kimberly Tang, Trang Nguyen, Amir Nasrolahi Shirazi, Ajoy Koomer

Pharmacy Faculty Articles and Research

Copper nanoparticles (CuNPs) have attracted growing attention in nanomedicine owing to their distinctive physicochemical, optical, and biological properties. Their large surface area, tunable size, ease of surface modification, and low cost make them attractive candidates for drug delivery, where they can both improve delivery efficiency and enable stimuli-responsive release. CuNPs also possess intrinsic antimicrobial, anticancer, anti-inflammatory, and photothermal activities, further broadening their biomedical utility. In this review, we synthesize recent advances in the synthesis, characterization, surface functionalization, and biomedical application of CuNPs, comparing chemical, physical, and green synthetic routes and their effects on stability, biocompatibility, and therapeutic efficacy. We examine …

Pharmacist-Led Initiative To Increase Naloxone Prescribing For Patients On High-Dose Opioids In A General Internal Medicine Clinic, Christine E. Leduc, Hyun J. Lee, Polly D. Fraga

The Lahey Journal

Abstract

Introduction:

Opioid overdose is a pressing public health concern in the United States. In 2022, prescription opioids were involved in 15% of all opioid deaths.1 Despite CDC recommendations for prescribing naloxone to high-risk patients, primary care physicians prescribe only 1.5 naloxone prescriptions per 100 prescriptions of high-dose opioids.2,3 Strategies are needed for healthcare institutions to expand naloxone access and mitigate opioid-related harm. This pilot study assesses the impact of a pharmacist-led quality improvement patient outreach initiative on increasing naloxone prescribing for adult patients taking ≥ 50 MME per day of prescription opioids as recommended by current CDC guidelines.

Methods: …