Medicine and Health Sciences Commons^™

Methylated Cfdna May Distinguish Between High- And Intermediate-Risk Uveal Melanoma: A Pilot Study, Mike Wu, Daniël P. De Bruyn, Ruben G. Boers, Aaron B. Beasley, Daan M. Hazelaar, Stavros Makrodimitris, Joachim B. Boers, Jolanda Vaarwater, Ronald O.B. De Keizer, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Saskia M. Wilting, Elin S. Gray, Wilfred F.J. Van Ijcken, Joost Gribnau, Annelies De Klein, Erwin Brosens, Emine Kiliç

Research outputs 2022 to 2026

Background: Uveal melanoma (UM) is a highly aggressive malignancy with a metastatic risk that depends on the molecular subclass. This subclass can be determined through molecular characterization of tumor-derived tissue. With eye-sparing treatments, tumor tissue is rarely available for molecular testing. We hypothesized that minimal invasive biomarkers such as methylated cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) can be used for prognosis and monitoring of patients. Methods: Plasma cfDNA was isolated from healthy blood donors (HBDs, N = 19) and UM patients (N = 22). Plasma was collected at baseline (localized disease, N = 13) and during follow-up (metastatic …

Perspective: Improving Social Connection And Inclusion Through Equitable Digital Health Solutions, Dominika Kwasnicka, Jaimon Kelly, Eleanor Quested, Loretta Baldassar, Suzanne Robinson, Richard Sinnott, Paul O’Halloran, Anne Tiedemann, Paul Flatau, Rajna Ogrin, Jane Farmer, Abby C. King

Research outputs 2022 to 2026

In this Perspective, we address the critical intersection of digital health, social connection, and health equity. Taking an interdisciplinary and complex adaptive systems perspective, we highlight evidence-based digital solutions to improve social connection and inclusion and, consequently, health outcomes. We describe actionable strategies for ensuring that digital health innovations benefit all, highlighting how user-centered design can address diverse needs, particularly for structurally disadvantaged populations.

Sarcomerogenesis: Evidence, Context And Key Stimuli—Response To The Commentary By Power Et Al., Anthony J. Blazevich, Walter Herzog, João Pedro Nunes

Research outputs 2022 to 2026

No abstract provided.

Body Mass Index, Prebiotic Supplementation During Pregnancy And Gestational Diabetes Mellitus Risk: An Effect Modification Analysis From A Randomised Controlled Trial, Rachelle A. Pretorius, Thomas R. Sullivan, Summer V.M. Walker, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Debra J. Palmer

Research outputs 2022 to 2026

Background: Prebiotic dietary supplementation has been shown to improve glucose homeostasis in type 2 diabetes patients. The aim of this analysis was to determine whether pre-pregnancy body mass index (BMI) modifies the effect of prebiotic supplementation from mid-pregnancy on reducing the risk of gestational diabetes mellitus (GDM). Methods: In a double-blinded, randomised controlled trial, pregnant women < 21 gestational weeks were randomly assigned (1:1) to consume daily prebiotics (14.2 g galacto-oligosaccharides and fructo-oligosaccharides) or placebo (8.7 g maltodextrin) powder. An effect modification analysis was performed to assess the heterogeneity of the effect of prebiotic supplementation in relation to pre-pregnancy BMI on GDM diagnosis. Results: Between June 2016 and November 2021, 329 women were assigned to the prebiotic group (50.4%), and 323 (49.5%) were assigned to the placebo group. Overall, 288 of 652 women (44.2%) were classified as overweight/obese prior to pregnancy (BMI ≥ 25 kg/m²). The distribution was balanced, with 146/329 (44.4%) randomised to the prebiotics group and 142/323 (44.0%) in the placebo group. Pre-pregnancy BMI modified the effect of prebiotic supplementation, with the intervention reducing GDM rates in women with a BMI ≥ 25 kg/m^{2 …}

Adding A Weight To Constrain The Trunk Increases Knee Joint Kinetics During Sidestep Cutting In Female Athletes, Daniel Kadlec, J. Jordan, Jacqueline Alderson, Sophia Nimphius

Research outputs 2022 to 2026

Sidestep cutting exposes the knee to high multiplanar loads that both challenge tissue capacity and provide an opportunity to develop resilience through progressive exposure. This study investigated task constraints applied at the trunk and preparatory step and changes in lower-body joint kinetics associated with ACL injury risk during sidestepping in female athletes. Twenty-one trained female athletes performed six sidestep conditions: pre-planned and unplanned sidesteps, each with and without trunk (holding ~ 5–7.5% body mass at chest level) and preparatory-step (ducking under an adjustable rope at eye height) constraints. Relative joint power at the hip, knee, and ankle was analysed using …

Effects Of Resisted Movement Training On Change-Of-Direction Speed In Recreationally Active And Trained Individuals: A Systematic Review With Network Meta-Analysis And Meta-Regression, Mingyang Zhang, Urs Granacher, Ruixiang Yan, Hallvard Nygaard Falch, Rodrigo Ramirez-Campillo, Kai Xu, Xing Zhang, Jinming Li, Shubo Xu, Yulin Luo, Duanying Li, Jian Sun

Research outputs 2022 to 2026

Background: The ability to change directions quickly is critical for performance and injury prevention in multidirectional sports, yet the influence of resisted movement training (R-MT) on change-of-direction (COD) speed remains uncertain. Therefore, we aimed to examine the effectiveness of various R-MT methods on COD speed in individuals ranging from recreational to international level and to determine the relationship between test angle and COD adaptations. Methods: We systematically searched PubMed/MEDLINE, Embase, Web of Science, SPORTDiscus, CINAHL, Scopus, and Google Scholar from inception to August 2025. Random-effects pairwise meta-analyses and a Bayesian network meta-analysis (NMA) synthesized effects of vertically resisted plyometric and …

Chlorinated Drinking Water Exposure Enriches Antimicrobial Resistance Pathways In The Infant Gut Microbiome: A Randomized Trial, Kimberley Parkin, Claus T. Christophersen, Valerie Verhasselt, Debra J. Palmer, Matthew N. Cooper, Susan L. Prescott, Desiree Silva, David Martino

Research outputs 2022 to 2026

Background: Water chlorination is essential for controlling harmful microbes in drinking water; however, the antimicrobial effects of chlorine-based disinfectants present in tap water may influence early-life gut microbial ecology.

Objective: To investigate the functional and compositional impact of chlorinated drinking water on the gut microbiome of infants.

Design: The waTer qUality and Microbiome Study (TUMS) was an Australian-based double-blinded, randomised controlled trial. Six-month-old infants (n = 197) received either de-chlorinated drinking water via benchtop filtration (treatment, n = 99), or regular chlorinated water (control, n = 98) for twelve months. Tap water and stool samples were collected at baseline and …

Free-Fall Normalised Peak Braking Velocity For Countermovement Jump Monitoring, Karol Kruczek, André Rebelo, Jason Lake, Michał Nowak

Research outputs 2022 to 2026

Background: Peak braking velocity (PBV) during the countermovement jump (CMJ) is used to describe descent strategy, but its interpretation is affected by countermovement depth. This study introduced free-fall normalised peak braking velocity (PBVFF), a dimensionless index expressing PBV relative to the displacement-specific theoretical free-fall velocity limit, and evaluated its reliability, performance associations and ranking consequences. Methods: Seventy injury-free male academy footballers (18.7 ± 1.6 years) performed three maximal hands-on-hips CMJs on dual force plates. Using retrospective observational routine monitoring data, one representative testing day per athlete was analysed. Two PBVFF variants were examined: PBVFF normalised to countermovement depth (PBVFFCMD) and …

Assessing Content Validity Of The Osteo-Taq(Aus) Using Cognitive Interviews: Cross-Jurisdictional Evidence From Uk Osteopathic Practice​​, Oliver P. Thomson, Elena Golder, Gopi Anne Mcleod, Jerry Draper-Rodi, Steven Vogel, Brett Vaughan

Research outputs 2022 to 2026

Background: The Osteopaths’ Therapeutic Approaches Questionnaire (Osteo-TAQ) has demonstrated content, construct, and face validity across multiple jurisdictions but required cognitive validation for use in the United Kingdom (UK). Objectives: To assess the cognitive content and face validity of the Australian-adapted Osteo-TAQ (Osteo-TAQ(Aus)) with practising UK osteopaths, and to determine whether any revisions were necessary. Methods: Cognitive interviews were conducted with six (n = 6) UK osteopaths using a combination of think-aloud and verbal probing techniques, informed by the Cognitive Interview Reporting Framework (CIRF). Interviews were recorded, transcribed, and analysed using team-based content analysis to identify issues of item interpretation, clarity …

Progression Of Non-Radiographic To Radiographic Axial Spondyloarthritis: A Risk Model Based On A Chinese Cohort Study, Rui Ying Deng, Xiaojia Xu, Jian Hua Peng, Feng Cai Shen, Yao Gong, Dan Min Wang, Hong Jin Liang, Shu Xin Huang, Zhao Peng Chen, Wen Long Wu, Ze Xin Zheng, Ling Lin, Zhi Duo Hou

Research outputs 2022 to 2026

Objectives: To evaluate the progression from non-radiographic axial spondyloarthritis (nr-axSpA) to radiographic axial spondyloarthritis (r-axSpA) in a Chinese cohort, identify associated risk factors in both clinical and imaging arms, and enable risk stratification based on these factors. Methods: Overall, 572 patients with nr-axSpA were enrolled with a median follow-up of 5 years. Cox proportional hazard regression analyses were conducted to identify potential risk factors associated with the progression from nr-axSpA to r-axSpA in both clinical and imaging arms. A risk-scoring system was then developed by assigning each independent predictor a weight based on its regression coefficient. Patients were subsequently categorized …

Cardiovascular Disease And Fracture Risk In People With Type 2 Diabetes: A Nationwide Matched Case–Control Study, Aksayan Arunanthy Mahalingasivam, Annika Vestergaard Kvist, Joop P. Van Den Bergh, Cassandra Smith, Joshua R. Lewis, Peter Vestergaard, Nicklas Højgaard Hessellund Rasmussen

Research outputs 2022 to 2026

To examine, among people with type 2 diabetes (T2D), whether cardiovascular disease (CVD) phenotypes and cardiovascular medications are associated with any fracture as the primary outcome and major osteoporotic fracture (MOF) as a secondary outcome. Nationwide registry-based matched case–control study in Denmark (2013–2021) among people with T2D. Cases were individuals with T2D who sustained an incident fracture (n = 12,390), and controls were fracture-free individuals with T2D matched 1:3 by age, sex, T2D onset date, and weighted Charlson Comorbidity Index (n = 37,170). The exposures were overall CVD, prespecified clinical CVD phenotypes (acute myocardial infarction (AMI), stroke, heart failure, atrial …

Cxcr3 Is Associated With T-Cell-Induced Heart Damage In Acute Rheumatic Fever, Francis M. Middleton, Reuben Mcgregor, Natalie Lorenz, Sarah Kilian, Anna E.S. Brooks, Saem Mul Park, Ciara Ramiah, Judith Tresidder, Timothy C. Barnett, Michael Serralha, William J. Martin, Florina Chan Mow, Glenn Pearson, Mark Mayo, David I. Broadhurst, Julie Bennett, Johann Brink, Nigel J. Wilson, Anna P. Ralph, Rachel H. Webb, P. Rod Dunbar, Jonathan Carapetis, Nicole J. Moreland

Research outputs 2022 to 2026

The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways. ARF shared immunological similarities with other inflammatory conditions, including elevated serum IL-6 and an increased frequency of circulating CD4⁺ T cells. However, elevation of the chemokine CCL5 and immunoglobulin IgG3, along with reduced expression of the chemokine receptor CXCR3 in the T cell …

Implementation And Effectiveness Of A Food Education Intervention To Promote Plant-Based Foods: A Partially Cluster-Randomized Controlled Trial, Henna Vepsäläinen, Satu Kinnunen, Sari Niinistö, Leena Forma, Suvi T. Itkonen, Tuuli E. Korhonen, Liisa Korkalo, Heli Kuusipalo, Jelena Meinilä, Kaija Nissinen, Susanna Raulio, Ros Sambell, Mari Åkerlund, Suvi M. Virtanen, Maijaliisa Erkkola

Research outputs 2022 to 2026

Background: Legumes can substitute for meat and are thus a particularly important food group for environmental sustainability. As the use of legumes among Finnish children is marginal, there is potential for a substantial increase in their consumption. However, food education delivered through early childhood education and care (ECEC) settings has rarely focused specifically on environmentally sustainable foods, such as legumes. This study describes the implementation and effectiveness of an ECEC-delivered food education intervention within the FoodStep study. Methods: The partially cluster-randomized FoodStep intervention aimed to increase the supply of vegetables, legumes, fruits, berries, and sustainable fish while reducing the provision …

Local Government Policies Restricting Unhealthy Outdoor Food Advertising In Australia: Stakeholder Perspectives Identify Political Willingness Is Key To Overcoming Barriers, Alexia Bivoltsis, Frith Klug, Jacinta Francis, Clare Whitton, Gina S.A. Trapp, Claire E. Pulker

Research outputs 2022 to 2026

Background: Unhealthy outdoor food advertising is strongly linked to poor diet, highlighting the need for policies. Western Australian (WA) local governments (LGs) can restrict advertising on their owned infrastructure through their Public Health Plans, but limited policy action has occurred. This study aimed to explore the perspectives of WA LGs and public health organizations (PHOs) on current and potential policies restricting unhealthy outdoor food advertising on LG owned infrastructure to (1) identify barriers and enablers to the policy making process, (2) assess the current level of political willingness (i.e. political want, political can and political must) and (3) inform development …

Body Composition And Muscle Health Changes After Providing Vascular Imaging Results In Older Adults: Secondary Analysis Of A Randomised Controlled Trial, Jack Dalla Via, Simone Radavelli-Bagatini, Marc Sim, Abadi K. Gebre, Catherine P. Bondonno, Kun Zhu, Shelby Mullin, John T. Schousboe, Richard J. Woodman, Markus P. Schlaich, Moira Sim, Pawel Szulc, Douglas P. Kiel, Wai H. Lim, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim: This secondary analysis of a 12-week parallel-group randomised controlled trial (RCT) aims to explore body composition and muscle health effects of providing healthy lifestyle education (Ed) with and without abdominal aortic calcification (AAC) results. Methods: A total of 240 Australian community-dwelling older men and women (mean ± SD age 68 ± 5 years; 58% female; 57.1% with evidence of AAC) were randomised to AAC + Ed (n = 121) or Control + Ed …

Eccentric Exercise: Muscle Damage To The New Normal, Kazunori Nosaka

Research outputs 2022 to 2026

No abstract provided.

The Relationship Between Dietary Sodium Intake And Cognitive Function: A Narrative Review, Samantha L. Gardener, M. Fu, L. Morini, T. Schwartzkopff, G. Savage, R. N. Martins, S. R. Rainey-Smith

Research outputs 2022 to 2026

Purpose of Review: This narrative review provides discussion on current evidence regarding the relationship between sodium intake and cognitive function in animal and human studies, as well as potential mechanisms underlying this relationship. Recent Findings: Recent evidence suggests high sodium intake is associated with development of cognitive impairment and neural dysfunction. Additionally, studies have proposed that high sodium intake is associated with increased aggregation of Aβ-amyloid and that hypertension (for which high sodium intake is a risk factor) modulates the relationship between Aβ-amyloid and development of cognitive impairment and Alzheimer’s disease. However, while animal studies demonstrate a consistent relationship between …

Temptation At The School Fence: A Qualitative Exploration Of The Impact Of External Food Outlets On The School Community, Sharonna Mossenson, Klug, Jacinta Francis, Siobhan Hickling, Lukar Thornton, Gina Trapp

Research outputs 2022 to 2026

Retail food outlets are commonly located in close proximity to schools, providing students with opportunities to purchase and consume food enroute to or from school. These outlets are typically unhealthy and disproportionately clustered near schools, and this trend has been increasing over time. While quantitative studies have established associations between school food environments and adolescent dietary behaviours, little is known about how school personnel perceive and experience their impacts. This qualitative study explored perspectives of school personnel (n = 9) from a secondary school in Perth, Western Australia, located 150 m from two retail food precincts (areas with a high …

Women’S Empowerment And Child Stunting In Peru: A Nationally Representative Analysis, Marisella Chumán-Sánchez, Brando Ortiz-Saavedra, Leonardo J. Uribe-Cavero, Anita P. Llamo-Vilcherrez, Joshua W. Moxey, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

Background: Child stunting remains a persistent public health challenge in Peru. Although women’s empowerment has been linked to improved child health, evidence on its domain-specific relationship with stunting remains limited. The objective of this study was to assess the association between women’s empowerment, across attitudes towards violence, social independence, and decision-making, and child stunting in Peru.

Methods: We conducted an analytical cross-sectional study using nationally representative data from the 2021 Demographic and Family Health Survey (ENDES), including 16,650 mother-child pairs. Analyses of women’s empowerment were conducted in a sub-sample with complete SWPER data (n = 12,696). Stunting was defined as …

Co-Creating An Intervention To Prevent Injuries In Police Force Recruits: A Concept Mapping Study Of Police Force Recruits, Police Force Staff, Health Professionals, And Research Experts, Myles Murphy, Andrea B. Mosler, Garth Allen, Alex Donaldson, Clare L. Ardern, Carolyn A. Emery, Martin Hägglund, Jonathan M. Hodgson, Joanne L. Kemp, Debra Langridge, Tiffany Mcalinden, Thomas Mirco, Sophia Nimphius, Simone Radavelli-Bagatini, Kiera Staley, Vanessa Sutton, Evert Verhagen, Andrea M. Bruder

Research outputs 2022 to 2026

Objective: Police force recruits have a high musculoskeletal injury burden, which results in a substantial economic burden and can lead to attrition. The objective of this study was to identify and prioritise the strategies perceived as important and feasible to reduce the prevalence, incidence, and burden of injury in police force recruits. Design: Mixed-methods concept mapping study. Methods: Forty-eight participants were recruited from four broad groups: police force recruits/officers; police force staff; health professionals; and research experts. Participants brainstormed statements in response to a prompt (“To prevent injury and/or reduce the impact of injury on law enforcement recruit training, I …

Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai

Research outputs 2022 to 2026

Background: Recent trials in Alzheimer’s disease (AD) demonstrate encouraging outcomes. These trials target risk mechanisms identified through genetic analysis whilst directly aiming to reduce progression rates. Evidence from other neurodegenerative diseases suggests the genetics of progression is distinct from risk of disease. To expand these initial successes and improve clinical outcomes further we need to understand genetics of progression of disease. These can be deduced through rigorous analysis of meticulously phenotyped longitudinal cohorts. In this study we first looked at known genetic drivers of risk, namely polygenic risk scores for AD and APOE‑ε4, to assess their role in progression. This …

Living Next Door To Mcdonald’S: A Qualitative Study Of Community Submissions And Resident Realities Pre- And Post Development, Roslyn Giglia, Jacinta Francis, Jana Buckle, Clare Whitton, Ros Sambell, Frith Klug, Lukar Thornton, Siobhan Hickling, Katherine Kent, Gina Trapp

Research outputs 2022 to 2026

Background: The proliferation of fast-food outlets (FFOs) in residential areas has raised growing concerns about their impact on community health, safety, and wellbeing. This qualitative study examined both pre-development community consultation submissions and post-development resident experiences surrounding the development of a McDonald’s outlet in a newly established suburb on the urban fringe of Perth, Western Australia (WA). Methods: Using a qualitative descriptive design, the study analyzed 183 community submissions lodged with the local council prior to development and conducted semi-structured interviews with 11 residents living within 300 m of the outlet after construction. Results: Content analysis revealed strong opposition, with …

Do Flywheel Exercises Provide Eccentric-Overload Training?, Darjan Spudić, Kazunori Nosaka

Research outputs 2022 to 2026

Interests in eccentric resistance exercises have been increasing in both research and practice. However, implementing eccentric resistance exercise training is often challenging due to the mechanical limitations of traditional training equipment. To address this, flywheel (FW) devices emerged as a practical alternative. FW devices are commonly considered to provide eccentric-overload training, in which the load is greater in eccentric than concentric phase. However, this is not always the case. In this article, we summarize the mechanical and physiological factors influencing the effectiveness of FW devices in achieving eccentric overload. Then, we discuss a significant limitation of FW resistance exercise in …

Acute Effects Of Accentuated Eccentric Loading On Mean Concentric Velocity During Resistance Training: A Systematic Review And Meta-Analysis, Jiahao Yang, Tsuyoshi Nagatani, Paul Comfort, Kristina L. Kendall, G. Gregory Haff

Research outputs 2022 to 2026

Background: Accentuated eccentric loading (AEL) may acutely enhance the concentric (CON) barbell velocity after the additional eccentric (ECC) load is removed, however there are inconsistent results regarding the effectiveness of this practice within the scientific literature. Objective: The aims of the present study were to: (1) examine the acute effects of applying AEL, only on the first repetition of a set, on mean barbell velocity during the CON phase of the first 3 repetitions of the set and (2) investigate the influence of the magnitude of ECC load, loading differential and exercise selection on the acute effects of AEL. Methods: …

Co-Design And Feasibility Testing Of A Midwife-Led Birth Debrief: An Implementation Science Project, Kate Buchanan, Phoebe Backhouse, Leanne Graham, Amy O’Meagher, Sara Bayes

Research outputs 2022 to 2026

Background: The period spanning pregnancy, birth and postpartum is characterised by psychosocial as well as physiological changes: many women experience new or worsening mental ill-health during the perinatal period. Midwives play a critical role in supporting and promoting psychosocial health by providing mental health education, counselling and screening. Often this includes a post-birth conversation, guided reflection, or debrief. Information about the effectiveness and experiences of specific and structured midwife-led birth debrief is scant. Aim: Our study aimed to assess the perceived effectiveness, experiences and implementability of a midwife-led birth debriefing intervention in one Australian maternity unit. Methods: A Type II …

Anaemia In Pregnancy In Rural New South Wales: A Retrospective Study Of Prevalence, Risk Factors, And Guideline Adherence, Yuanwei Zhang, Esther Adama, Uchechukwu Levi Osuagwu

Research outputs 2022 to 2026

Aim: To determine the prevalence of anaemia in pregnancy in rural New South Wales (NSW) and assess the alignment of screening and treatment practices with the 2020 Australian Pregnancy Care Guidelines (APCG).

Methods: A retrospective cohort study at the Regional Hospital using records from 301 women who gave birth between 1st January and 4th September 2024. Data were sourced from eMaternity and PowerChart systems, focusing on haemoglobin and ferritin levels, demographic factors, iron deficiency risk factors, and birth outcomes.

Results: Iron deficiency was identified in 61.8% of women, with 6.0% diagnosed with iron deficiency anaemia (IDA). These rates were lower …

Effects Of Lower Limb Joint Manipulation On Squat Strength And Ankle Range Of Motion: A Sham-Controlled Double-Blind Randomised Cross-Over Trial, Reneigh Morley-Hart, Barrett Losco, Alasdair R. Dempsey, G. Gregory Haff, Sasha L. Aspinall

Research outputs 2022 to 2026

Background: The back squat is a commonly prescribed exercise for developing lower body strength. The ability to squat can be affected by reduced ankle dorsiflexion range of motion (DF-ROM), leading to limited squat depth and dysfunctional compensatory movement patterns.

Objective: To investigate the effect of high-velocity low-amplitude lower limb manipulations on 1 repetition maximum (1RM) back squat strength, sagittal plane ankle kinematics during a squat, and active DF-ROM in individuals with asymptomatic deficits in DF-ROM.

Methods: Twenty-six enrolled; Twenty-four analysed resistance-trained participants with asymptomatic deficits in DF-ROM participated in this double-blind randomised sham-controlled cross-over trial. Interventions involved high-velocity low-amplitude joint …

Graft Survival And Rejection With Repeated Human Leukocyte Antigen (Hla) Mismatch In Kidney Transplantation: A Retrospective Multicentre Cohort Study Protocol, Henry Guo, William Mulley, Narelle Watson, Rhonda Holdsworth, Anne Taverniti, Jon Downing, Alycia Thornton, Lucy Sullivan, Fiona Hudson, Christopher E. Davies, Ryan Gately, Armando Teixeira-Pinto, Germaine Wong, John Kanellis, Wai Lim

Research outputs 2022 to 2026

Background: Candidates awaiting repeat kidney transplantation face substantial immunological barriers due to prior human leukocyte antigen (HLA) allo-sensitisation. Re-exposure to previously mismatched HLA antigens may increase the risk of acute rejection and premature graft loss. Although avoidance of repeat HLA mismatches (RMM) has been standard practice, emerging evidence suggests this risk varies according to the specific HLA allelic RMM and anti-HLA antibody profile to the RMM. Here we describe the protocol for a retrospective registry-based cohort study that aims to determine the differences in graft outcome between recipients who received kidney transplants with and without RMM, and to examine the …

My Story Is Good… It’S Not Like That For All: Uneven Access To Contraception Among Incarcerated Women In New South Wales, Australia, Helene Smith, Basil Donovan, Jocelyn Jones, Tony Butler, Paul Simpson

Research outputs 2022 to 2026

Background: Evidence indicates high levels of unmet contraceptive need among justice-involved women, linked to intersecting vulnerabilities such as housing instability, substance use, violence and poor mental health. In Australia, limited research has explored how women in prison navigate access to family planning services. This study aimed to examine the experiences of incarcerated women in New South Wales (NSW) in accessing contraception and making fertility-related decisions.

Methods: The study formed part of the Second Sexual Health and Attitudes of Australian Prisoners (SHAAP-2) study. Seventeen women aged 19–45 were recruited from two NSW correctional centres. Semi-structured qualitative interviews were conducted face-to-face or …

Preventive Behaviors Associated With Fall Incidence Among Older Adults Living In Rural Communities Of Thailand: A Cross-Sectional Study, Rujira Nonsa-Ard, Sirapat Khodseewong, Kasama Wongprachum, Chaiwut Bourneow, Ploypailin Aneknan, Sumattana Glangkarn, Davina Porock

Research outputs 2022 to 2026

Background: The escalating population of older adults poses a significant challenge, particularly in lower-middle-income countries like Thailand. Falls represent a critical public health concern in this demographic. This study aimed to identify risk factors influencing fall occurrence in older adults within a specific rural community context, where the majority of participants remain engaged in farm work.

Methods: A cross-sectional study design was utilized, involving 1,256 participants recruited by the multistage random sampling approach. Data were collected via a questionnaire that included: demographic information, the Thai version of the Barthel Activities of Daily Living (ADL), the Thai Fall Risk Assessment Tool …