Medicine and Health Sciences Commons^™

An Occupational Therapy Program For Improving Caregiving Performance And Satisfaction With Performance Among Caregivers For Individuals With Neurological Conditions, Andrea Marie Molus

Occupational Therapy Capstone Presentations

This capstone project was to develop a program that would decrease the symptoms of caregiver burnout to increase the performance and satisfaction with performance among caregivers of individuals with neurological conditions. Caregivers can develop burnout when the burden of caregiving increases to the extent that the experience is not a healthy option for the caregiver or care recipient (Kasuya et al., 2000). Three occupational therapy theories were used to support this project: Model of Human Occupation, Tolgia’s Dynamic Interactional Approach, and Andragogy Learning Theory for Adult Learners. An online resource website was developed to help disseminate the information used in …

Occupational Therapy's Role In Helping Individuals In The Us Justice System Transition From Incarceration To The Community, Kathryn E. Foster

Occupational Therapy Capstone Presentations

Individuals with cognitive disabilities face unique challenges in their transition and integration from prison settings. Occupational therapy offers tailored, client-centered reentry services to address their needs and the evidence on impact is limited. The purpose of this project was to examine the efficacy of strengths-based, occupational therapy-led reentry services on the reentry of individuals on probation and parole with a cognitive challenge into society following incarceration. I used a retrospective, mixed methods design to complete this project. Community-based reentry services were provided post-release in the local St. Louis community. Participants included both occupational therapy practitioners tracking process and impact measures, …

Accuracy Of Interproximal Reduction In Commonly Used Operator Positions Using An Intraoral Scanner, Behnoush Bakhtiari

Theses & Dissertations

Introduction: The aim of this study was to determine operator’s best position when doing interproximal reduction. Also, to determine if these positions are ergonomically recommended.

Materials and methods: 54 sets of upper and lower models were scanned and 3D-printed. Air-rotor stripping was performed at different provider positions. Vertical and horizontal deviations were measured, and errors were recorded.

Results: In LA, there was no statistically significant difference between vertical deviations in P7 and 11, however, they were both superior to P9. In LL, P11 leads to significantly lower vertical deviation than P7 and 9. In LR, P9 and 11 were superior …

Assessing Gender Differences In Usd Students In The Consumption Of Pornography, Abbey Selleck

Honors Thesis

While pornography consumption has been studied many times in the past decade, little has been done on assessing the gender differences behind it. This study sought out to find those differences. A total of 306 University of South Dakota students participated in an online pornography survey. There was 231 females and 75 males. When asked about intentionally consuming pornography, there was 241 responses, 180 females and 61 males. Of those responses, 57 males (93%) and 142 females (79%) said they intentionally consume pornography. As hypothesized, a higher percentage of men said they consumed porn regularly (34%) than did women (4%). …

Genetic Influences On The Response To Neuromodulation In Craving Behaviors, Carly J. Haring

Honors Thesis

Obesity and eating disorders are highly prevalent in the United States. People who suffer from obesity and/or eating disorders face serious health consequences and even death. Current treatments are not effective as recovery rates are low, so there is a dire need for an effective treatment for obesity and eating disorders. There have been studies investigating the use of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex (DLPFC) as a means of treatment for these people. While findings show promise, there is much variability. The goal of this study is to further prior …

Physician Assistant Professional Issues: Optimal Team Practice In South Dakota, Michael J. Eggum

Honors Thesis

Optimal team practice (OTP) is a policy meant to modernize physician assistant (PA) practice laws, and one of the most controversial associated changes is removing the requirement for a PA to have a supervisory/collaborative agreement with a physician. In South Dakota (SD), there have been three OTP-related bills that failed to pass during their respective legislative sessions: House Bill 1163 from 2021, Senate Bill 134 from 2022, and Senate Bill 175 from 2023. This study was conducted as a survey consisting of 11 questions administered to SD PAs. The goal of this survey study was to determine PA understanding/disposition towards …

Intramuscular Administration Of The Host-Derived Immunostimulant Cpdi-02 Increases Protection Of Outbred Mice And Piglets Against Dermal Mrsa Infection In A Curative Setting And Is Well Tolerated After Repeated Administration, Jason P. Stewart

Theses & Dissertations

Staphylococcus aureus is the most common cause of bacterial skin and soft tissue infections (SSTIs) and the leading cause of hospital-associated infections in the United States. The abundance of S. aureus infections is due, in part, to its virulence factors that suppress host immune system and the development of antibiotic resistance strains such as methicillin-resistant S. aureus (MRSA). In contrast to antibiotics, Host-Directed Therapeutics (HDTs), avoid the pitfalls of antibiotics by targeting the host for immune system rather than targeting the pathogen. This mechanism of action avoids selective evolutionary pressure, which leads to antibiotic resistance and helps the host immune …

Effect Of Computerized Cognitive Training In Persons With Multiple Sclerosis, Sam Jack

Theses & Dissertations

Between one million and 1.75 million persons with multiple sclerosis (PwMS) worldwide are estimated to suffer from cognitive impairment. Unfortunately, there is currently no consensus on the best treatment for cognitive impairment in PwMS. Finding non-pharmacological interventions to mitigate cognitive decline is essential to ensure that quality of life for PwMS matches our ability to treat and mitigate their physical symptoms of MS. Computerized cognitive training has emerged as a potential option for PwMS suffering from cognitive impairment. The objective of this study was to determine the effectiveness of computerized cognitive training with BrainHQ on changes in cognitive impairment for …

Use Of Pre-Transplant Cmi To Predict Infection And Mortality Post-Cardiac Transplantmortality Post-Cardiac Transplant, Chetaj A. Mahabir

Theses & Dissertations

This paper discusses a study investigating the relationship between the cell-mediated immunity (CMI) level before cardiac transplant and the incidence of infection and mortality after the transplant. CMI is an important measure of a person's immune system. The study included 126 patients who underwent cardiac transplants between September 2011 and January 2020. Out of these, 21 patients had a low CMI level (<225), and 105 had a high CMI level (≥ 225) before transplant. The mean CMI level in the low CMI group was 175.3, while in the high CMI group, it was 479.9. The two groups were similar except for the lower white cell count and cardiac output in the CMI< 225 groups and the higher Caucasian demographic in the CMI≥ 225 groups. The study concludes that patients with lower CMI levels before cardiac transplant have a higher risk of infection (p=0.052) and mortality (p=0.005) one year after the transplant. The risk of dying for patients with CMI <225 is 12.9 times the risk of dying for patients with CMI ≥ 225 after adjusting for the other covariates in the model. However, this study has some limitations including its retrospective nature, small sample size, and single-center design. Further studies are needed to replicate these findings and investigate the optimal immunosuppressive regimens based on baseline CMI levels.

Targeted Therapies For Improving The Treatment Of Sonic Hedgehog And Myc Driven Medulloblastoma, Bharti Sethi

Theses & Dissertations

The aim of this thesis to develop a novel potent dual inhibitor to target BDR4/PI3K and MDM2/ XIAP pathways to treat medulloblastoma. A series of new analogs were synthesized, characterized, and evaluated in vitro and in vivo using xenograft and orthotopic mouse models.

In Chapter 1 an overview of Blood brain barrier such as their components, physiology, current drug delivery system and nanomedicines to treat medulloblastoma.

Chapter 2 includes synthesis of new molecule MDP5, targeting both BRD4 and PI3K pathways. We used X-ray crystal structures and molecular modeling approach to confirm the interactions between MDP5 with BD domains from both …

Center Based Cardiac Rehabilitation Outcomes Associated With Covid-19 Pandemic: A Retrospective Comparative Cohort Study, Haley Williams, Kayla Woodworth

Doctor of Nursing Practice Projects: College of Nursing

Background: Traditional cardiac rehabilitation (CR) is a multidisciplinary, multifaceted program for cardiac patients. Throughout the Covid-19 pandemic, health care, including center-based CR (CBCR) programs, were closed to in-person sessions. Even with the return to CBCR participation, patient outcomes may have been affected by this disruption in care. The goal of this study was to determine if CR participation outcomes differed before and after CBCR program closure due to Covid-19.

Methods: A retrospective comparative cohort design was used to examine CR participant outcome data before and after the Covid-19 pandemic. Convenience sampling of CR participants at a large, urban …

Interpretive Phenomenological Analysis [Ipa]: Examining The Impact Of Sleep Disturbances On Lived Experiences Of Persons With Parkinson’S Disease (Pwpd), Adriana Ornelas, Angela Blackwell, Karen Aranha

Spring 2023 Virtual OTD Capstone Symposium

Introduction: This investigation aimed to examine the lived experiences of PwPD who suffer from insomnia. Sleep disturbance affects up to 96% of individuals with PD. The non-motor symptom (NMS) significantly reduces HR-QOL, positively correlates with disease severity and duration, and increases the disease burden of care. Due to the nature of the disease, typical sleep hygiene protocols may not be the most effective intervention for this population. Understanding their challenges is vital to developing a sleep hygiene protocol tailored to their needs.

Methodology: A pilot qualitative study using an interpretive phenomenological analysis (IPA) with PwPD (N=12). The study received IRB …

Complementary Medicine And Its Perceived Effects On Cancer Patients, Madison A. Sundvold

Honors Thesis

This research examines the perceived effects of the top ten complementary medicine types on cancer patients' perceived health outcomes, when used in combination with Western or evidence-based medicine. This thesis analyzes various peer-reviewed articles as a literature review and utilizes a previous honors thesis conducted survey of the general population. It studies the depth of knowledge that people have of complementary medicine types and if they combine the resource with regular Western medicine. The purpose of this study is to examine if complementary medicine used decreases the side effects associated with cancer treatment, such as fatigue, pain, and nausea. After …

Mobile Munchies: An Occupation-Based Transitional Skills Program For Adolescents, Reilly S. Dujmovic

Occupational Therapy Capstone Presentations

This capstone project is focused on program development in the area of life/work skills for adolescents in a special education setting. The specific interest was in transition skills for adolescents, or skills that promote independence in ADLs, IADLs, and leisure, and work activities following formal education. The goal of this project was to develop work programming as an intervention to teach transition skills to adolescents in a special education classroom setting. The programming developed was based on programming the special education classroom has used in the past. Programming was modified to take an occupational therapy lens to reach the goal …

Promoting Social-Emotional Development In Preschool Children Using A Trauma Informed, Sensory Integrative Approach, Sarah M. Mcgoldrick

Occupational Therapy Capstone Presentations

The incidence of sensory processing difficulties and related behaviors is increasing in young children, which supports the need for early intervention and support. The purpose of this study was to determine the effectiveness of TBRI® Nurture Group© in improving social emotional and sensory processing skills in preschool aged children while reducing the number of negative behaviors observed. The project was conducted in a four- and five-year-old preschool classroom at the Early Learning Center in Edina, Minnesota. Nurture Group© sessions occurred over the span of ten weeks in small groups of about three to four students. Students worked on identifying calming …

Telehealth Integration In Primary Care, Ashley Simons

Doctor of Nursing Practice Projects

Telehealth has been proven to be a useful and integral tool in primary care settings. Carlinville Family Health Care Clinic, a rural health clinic, has the current ability to conduct Telehealth visits but is not currently doing so. They have several programs available that are equipped with Telehealth capabilities. The physicians cite lack of education on these programs and lack of a standard streamlined practice for which program to use or how to use it.

According to the physicians in this practice, along with their patients, the use of Telehealth has multiple advantages. Because visits in this clinical are usually …

Primary Care Management Of Breast Cancer Screening, Katelyn Phillips, Lainey Brown

Doctor of Nursing Practice Projects

Breast cancer remains the most prevalent cancer diagnosis and is the second leading cause of cancer death among women in the United States. Mammograms have been identified as an effective screening tool that can detect breast cancer in the early stages of the disease, before symptoms develop, and allow the possibility of a cure. The project aimed to identify women in the primary care setting with outstanding mammography orders and implement a more systemic outreach program to improve patient adherence. The intervention was a telephone outreach program in which the students conducting the project contacted patients with unsatisfied mammogram orders …

Evaluating The Impact Of Routine Enteral Iron Fortification On Gastrointestinal Dysbiosis In Premature Infants, Matthew Van Ormer

Theses & Dissertations

The gastrointestinal microbiome in preterm infants bears significant influence on optimal outcomes – dysbiosis is shown to substantially increase the risk of the life-threatening necrotizing enterocolitis, whereas optimal microbiome composition improves nutrient digestion and immune function. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurological development. However, excess colonic iron exhibits potent oxidation capacity and alters the competitive environment of microbes – potentially facilitating the proliferation of pathological bacterial strains in the gut. Of note, breastfed preterm infants routinely receive iron fortification starting at 14 days of life and are …

Detection Of Sars-Cov-2 Mutations In Vermillion, Sd, Wastewater Utilizing Probe-Based Rt-Qpcr, Matthew J. Schmitz

Honors Thesis

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the subgenus Sarbecovirus, has presented numerous public health challenges for communities across the globe. As demonstrated by the Delta variant (B.1.617.2) and the recent Omicron variants, the virus can mutate and pose new risks for communities, such as reinfection, increased transmissibility, and variable mortality. As such, accurately monitoring the spread of specific variants has become a priority for public health agencies. However, clinical testing faces various limitations, and the increased use of at-home test kits inhibits surveillance. Wastewater-based epidemiology (WBE) can monitor infection rates of entire …

Creation Of Tatde Rlnps For The Excision Of Integrated Hiv-1 Proviral Dna, Mahmudul Hasan

Theses & Dissertations

The persistence of integrated human immunodeficiency virus type 1 (HIV-1) proviral DNA despite combination antiretroviral therapy (ART) is the principal challenge to eliminating HIV-1 infection. This is made ever more complex based on the high viral mutation rates, diversity and resistance profiles. Taken together, these factors present principal obstacles towards any means to eliminate the virus from its infective human host. To address these factors, we have developed and validated a TatDE rLNP RNA delivery system. The system utilizes Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) guide RNAs (gRNAs) to target multiple exons of an integrated proviral HIV-1 (tat_{1-2 …}

The Brain On Death Row: Reconciling Neuroscience & Categorical Exemptions From Execution, Alexa Johnson-Gomez

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Health Care Industry Is Ready For A Revolution: Its Privacy Laws Are Not, Erin Rutherford

Minnesota Journal of Law, Science & Technology

No abstract provided.

Infrared Thermography (It) And Subepidermal Moisture Scanning (Sem) To Identify Early Tissue Injury And Reduce Hospital Acquired Pressure Injuries In Patients Undergoing Procedures Greater Than Four Hours In Duration, Irish Mills Parker, Makaela Waddell, Alexa Johnson

Doctor of Nursing Practice Projects: College of Nursing

Objective: The purpose of this pilot feasibility study was to more effectively prevent hospital-acquired pressure injuries in high-risk patients by using infrared thermography and subepidermal moisture scanning to identify early signs of tissue injury from pressure. Methods: Data was collected in the Cardio-Vascular Intensive Care Unit (CVICU) and cardiac medical-surgical care floors at Nebraska Medicine. Inclusion criteria are adults, scheduled for a surgery or procedure(s) predicted to last four or more hours, and planned admission to the ICU afterward. Participants were scanned with FDA-approved infrared thermography (IT) and subepidermal moisture (SEM) scanners before their procedure, two hours post-procedure, and then …

Increasing Communication Of Patient Daily Goals During Interdisciplinary Rounds In An Inpatient Pediatric Cardiac Unit, Sage Bailey

Doctor of Nursing Practice Projects: College of Nursing

Introduction: Ineffective communication between interdisciplinary team members in a pediatric inpatient setting results in poor documentation compliance and decreased staff satisfaction of daily goals. The use of a standardized patient daily goal sheet improves effective communication among interdisciplinary team members. The primary aims of this study were to improve RN satisfaction and knowledge regarding interdisciplinary communication, improve verbalization of patient daily goals in daily rounds, increase the number of daily goals verbally discussed and improve the quality of documentation in the electronic medical record (EMR). Methods: Data were collected on a pediatric academic 30-bed cardiac care unit involving 100 nurses. …

Targeting The Cxcr1/2 Axis In Pancreatic Ductal Adenocarcinoma, Caitlin Molczyk

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is notoriously challenging to diagnose and treat. This tumor has an aggressive phenotype and benign clinical features until severe disease dissemination, which makes it too late to eradicate. Although it is only the 10th most common cancer in the United States, it is the fourth leading cause of cancer-related deaths. The treatment options are complicated further due to tumor heterogeneity, meaning not all tumor cells are in the same state phenotypically or epigenetically. They also express cytokines, chemokines, and receptors differently. Here we explore the usage of CXCR1 and CXCR2 and their ligands in PDAC tumor …

Nitrous Oxide Exposure In The Workplace: A Study Of Pediatric Dental Clinics In Saudi Arabia, Badr Alhemayyed

Theses & Dissertations

Nitrous oxide (N2O) is frequently used in dental offices and is regarded as safe for patients getting dental work done. However, nitrous oxide exposure at work has been linked to harmful health outcomes like infertility and diseases of the liver, kidneys, and nervous system. Unfortunately, Saudi Arabia lacks an occupational safety and health regulatory body, which may influence dental professionals' safety. This is a serious problem because it puts dental professionals at risk of nitrous oxide exposure at work.

Exposure to nitrous oxide at work can have serious health consequences. Therefore, it is critical to evaluate dental professionals' occupational exposure …

Impact Of The Covid-19 Pandemic On The Management Of Risk Factors In Patients With Stable Atherosclerotic Vascular Disease, Dean Karalis, Patrick Moeller, Albert Crawford, Maria Janelli, Scott Hessen

Division of Cardiology Faculty Papers

Background

Effective control of risk factors in patients with ASCVD is important to reduce recurrent cardiovascular events. However, many ASCVD patients do not have their risk factors controlled, and this may have worsened during the COVID-19 pandemic.

Methods

We retrospectively evaluated risk factor control among 24,760 ASCVD patients who had at least 1 outpatient encounter both pre-pandemic and during the first year of the pandemic. Risk factors were uncontrolled if the blood pressure (BP) ≥ 130/80 mm Hg, LDL-C ≥ 70 mg/dL, HgbA1c ≥ 7 for diabetic patients, and patients were current smokers.

Results

During the pandemic, many patients had …

Higher Dose Corticosteroids In Patients Admitted To Hospital With Covid-19 Who Are Hypoxic But Not Requiring Ventilatory Support (Recovery): A Randomised, Controlled, Open-Label, Platform Trial, Recovery Collaborative Group

Faculty, Staff and Student Publications

BACKGROUND: Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.

METHODS: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation

FINDINGS: Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen …

Higher Dose Corticosteroids In Patients Admitted To Hospital With Covid-19 Who Are Hypoxic But Not Requiring Ventilatory Support (Recovery): A Randomised, Controlled, Open-Label, Platform Trial, Recovery Collaborative Group

Faculty, Staff and Student Publications

BACKGROUND: Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.

METHODS: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation

FINDINGS: Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen …

Oxidative Damage Together With Post-Occlusive Re-Oxygenation Kinetics, In Calf Muscle, Implicate Microvessels In The Myopathy Of Peripheral Artery Disease, Molly Schieber

Theses & Dissertations

Background:Peripheral Artery Disease (PAD) is characterized by calf muscle fibrosis and myofiber oxidative damage (OxD). Our laboratory has demonstrated architectural changes of calf-muscle microvessels (

Methods:Gastrocnemius biopsies were collected from controls, patients with Stage II PAD, and Stage IV patients with limb-threatening ischemia. Carbonyl adducts (CA; oxidative damage), and Heme Oxygenase-1 (HO-1; anti-OxD in microvessels) were quantified in microvessels (

Results: Post-occlusive re-oxygenation of calf muscle was slowed in Stage II patients versus controls. Kinetic parameters correlated poorly with Ankle-Brachial Index. Microvessel CA was increased in pre- and post-exercise Stage II patients and in Stage IV patients versus …